TWAS hub - TCTN1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Muscle Skeletal	0.1459	0.0531	4.6e-05	0.061	NA	0.067	NA	0.073	1.3e-06	NA	3.9e-07	NA	1.2e-07
2	YFS	Blood	0.0471	0.0200	7.0e-06	0.004	0.015	0.015	0.016	0.010	1.6e-02	6.6e-06	9.2e-06	3.1e-06	2.8e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Blood Eosinophil Count	12.2	94.1	151.3	-6.1	-12.3
Hypothyroidism (self reported)	11.6	26.7	53.4	-0.0	-7.3
Hypothyroidism/myxoedema (self-reported)	10.6	20.7	41.3	-0.4	-6.4
Blood Platelet Count	10.2	117.7	121.0	-11.0	-10.7
Exposure to tobacco smoke at home	8.9	10.0	10.8	-3.3	-3.0
Coronary Artery Disease (CAD)	8.5	10.1	18.6	-1.3	-4.3
Medication: Levothyroxine sodium	8.3	14.0	28.1	0.1	-5.3
Seen doctor (GP) for nerves, anxiety, tension or depression	7.3	11.2	13.8	3.7	2.9
Mouth/teeth dental problems: Bleeding gums	7.3	9.5	10.0	-3.2	-3.0
Alcohol drinker status: Previous	7.0	8.0	11.6	3.4	2.1
Hearing aid user	5.8	6.5	11.2	-3.3	-1.4
Major Depression (MDD)	5.5	6.7	12.7	3.6	0.8
Exposure to tobacco smoke outside home	5.5	7.3	11.7	-1.7	-3.4
Medication: Ventolin 100micrograms inhaler	5.4	6.9	9.4	2.1	3.1
Medication: Lansoprazole	5.2	5.9	6.8	-2.6	-2.2
Seen a psychiatrist for nerves, anxiety, tension or depression	4.8	6.2	9.1	1.8	3.0
Blood White Count	4.7	34.8	56.4	-3.6	-7.5
Supplements: Zinc	4.7	5.1	5.7	2.1	2.4
Headache pain in last month	4.6	7.9	12.5	1.8	-3.5
Diabetes diagnosed by doctor	4.2	6.9	9.2	-2.1	-3.0
Prospective memory result	3.6	4.4	8.8	3.0	-0.1
Shortness of breath walking on level ground	3.5	4.2	7.9	0.7	2.8
Number of full brothers	3.3	4.1	6.0	2.5	1.5
Medication: Seretide 50 evohaler	3.3	3.9	4.1	1.9	2.0
Tinnitus: Yes, now most or all of the time	3.3	3.9	7.1	0.8	2.7
Medication for pain relief, constipation, heartburn	3.2	5.4	10.6	0.4	3.3
Schizophrenia (2014)	3.1	6.8	13.4	3.7	-0.4
Tinnitus: Yes, but not now, but have in the past	3.1	3.3	3.6	1.9	1.8
HDL Cholesterol	3.0	5.1	7.9	1.5	2.8
Type 2 Diabetes (T2D) (2012)	3.0	3.5	5.0	2.2	1.4
Diabetes (self-reported)	3.0	4.6	5.5	-1.9	-2.3
Suffer from ‘nerves’	3.0	4.8	5.0	2.1	2.2
Medication: Omeprazole (e.g. Zanprol)	3.0	3.6	4.3	-1.7	-2.1
Medication: Simvastatin	2.9	4.3	5.4	-2.3	-1.8
High cholesterol (Self-reported)	2.9	5.2	6.2	-2.0	-2.5
Cholesterol lowering medication	2.9	4.2	4.4	-2.1	-2.0
Systolic Blood Pressure	2.8	14.1	18.0	-3.2	-4.2
Frequency of unenthusiasm / disinterest in last 2 weeks	2.8	3.7	5.0	1.5	2.2
Vitamin and mineral supplements	2.7	3.6	5.8	-2.4	-1.2
Breastfed as a baby	2.7	3.3	4.9	2.2	1.3
Birth weight	2.7	5.9	6.4	2.3	2.5
Comparative height size at age 10	2.7	14.7	21.7	4.7	2.8
Ever depressed for a whole week	2.7	3.3	3.5	1.7	1.9
Schizophrenia (2018)	2.6	5.4	10.7	3.3	-0.3
Mouth/teeth dental problems	2.6	3.9	7.2	0.8	2.7
Birth weight of first child	2.6	4.6	6.4	1.7	2.5
Mood swings	2.5	4.5	5.2	2.3	1.9
Neuroticism (2016)	2.4	3.4	6.9	-0.1	-2.6
Number of incorrect matches in round	2.4	4.0	7.8	2.8	0.3
Happiness	2.4	2.9	3.5	1.5	1.9
Falls in the last year	2.3	3.2	5.6	0.9	2.4
Qualifications: NVQ or HND or HNC or equivalent	2.3	2.8	4.4	-2.1	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	2.3	4.7	8.1	2.8	1.1
Lupus	2.2	3.3	6.3	-0.5	-2.5
Age at first live birth	2.2	4.0	6.7	1.1	2.6
Bipolar Disorder or Schizophrenia	2.1	5.0	10.0	3.2	-0.1
Severe depression (siblings)	2.1	2.4	3.6	1.1	1.9
Depression (self-reported)	2.0	2.4	3.0	1.3	1.7
Pulse wave peak to peak time	2.0	2.4	4.7	2.2	-0.2
Illnesses of father: High blood pressure	2.0	2.5	3.0	-1.7	-1.4
Ever unenthusiastic/disinterested for a whole week	1.8	2.2	3.9	0.6	2.0
Medication: Cholesterol lowering	1.8	2.7	4.2	-1.1	-2.0
Medication: Paracetamol	1.8	3.0	6.1	-0.1	-2.5
Medication for cholesterol, blood pressure or diabetes	1.8	2.9	3.9	1.4	2.0
Worry too long after embarrassment	1.8	3.0	4.1	-2.0	-1.4
Illnesses of siblings: Diabetes	1.8	2.2	2.3	-1.5	-1.4
Illnesses of father: None of the above (group 1)	1.8	2.2	2.3	1.4	1.5
Supplements: Calcium	1.8	2.0	2.6	-1.6	-1.2
Pack years of smoking	1.8	2.7	5.3	2.3	0.4
Triglycerides	1.7	2.8	3.1	-1.6	-1.8
Cardiovascular Disease	1.7	5.8	8.9	-1.6	-3.0
Multivitamins +/- minerals	1.7	2.1	3.6	1.9	0.8
Qualifications: None of the above	1.7	3.6	4.8	2.2	-1.6
Hayfever/allergic rhinitis (self-reported)	1.7	2.2	2.7	1.7	1.3
Number of live births	1.7	2.4	4.6	0.5	-2.1
Heart disease (mother)	1.7	2.1	2.8	-1.2	-1.7
Alcohol intake frequency.	1.7	3.9	5.2	2.3	1.6
Age at last live birth	1.7	2.4	3.6	1.1	1.9
Depression (Nagel 2018)	1.6	2.5	4.0	0.9	2.0
Reaction Time	1.6	3.1	4.9	-1.2	-2.2
LDL Cholesterol	1.6	2.5	3.3	-1.3	-1.8
Heel T-Score	1.6	12.6	15.6	3.1	4.0
Type 2 Diabetes (T2D) (2018)	1.6	3.0	3.6	-1.5	-1.9
Qualifications: CSEs or equivalent	1.6	2.1	3.4	-1.8	-0.8
Worrier / anxious feelings	1.6	3.1	6.1	2.5	0.3
Pulse rate, automated reading	1.6	5.3	6.6	-2.6	-2.0
Mother’s age at death	1.6	2.0	3.3	-0.9	1.8
Risk taking	1.6	2.3	4.0	-2.0	0.8
Systolic blood pressure, automated reading	1.5	4.3	4.8	-2.0	-2.2
Pack years adult smoking proportion	1.5	2.3	4.3	2.1	0.5
Frequency of tenseness / restlessness in last 2 weeks	1.5	2.4	3.9	0.9	2.0
Comparative body size at age 10	1.5	4.1	7.5	-0.9	2.7
Medication: Omeprazole	1.5	1.7	1.7	-1.3	-1.3
Chest pain or discomfort	1.5	2.2	4.2	2.1	0.4
Ever had bowel cancer screening	1.5	1.7	2.6	1.6	-0.9
Ever had prostate specific antigen (PSA) test	1.5	1.8	2.6	-1.6	-1.0
Past tobacco smoking	1.4	2.6	4.7	0.7	2.2
Asthma	1.4	2.7	4.7	0.9	2.2
Illnesses of mother	1.4	1.7	3.4	0.0	1.8
Medication: Blood pressure	1.4	2.5	4.6	-0.7	-2.1
Medication: Ibuprofen	1.4	1.7	3.2	0.3	1.8
Blood Red Count	1.3	12.1	19.0	-2.3	-4.4
Bilateral oophorectomy (both ovaries removed)	1.3	1.5	2.2	-1.5	-0.8
Impedance of arm (right)	1.3	5.9	11.9	0.0	-3.4
Pulse wave Arterial Stiffness index	1.3	1.6	3.1	-1.8	0.1
Mean time to correctly identify matches	1.3	2.4	4.6	-0.5	-2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.5	1.7	-1.3	-1.2
Asthma (self-reported)	1.3	2.6	4.6	0.8	2.1
Rheumatoid Arthritis	1.2	1.7	3.0	-0.7	-1.7
Medication: Metformin	1.2	1.7	2.3	-1.5	-1.1
Relative age voice broke	1.2	1.8	1.9	-1.4	-1.3
Qualifications: A levels/AS levels or equivalent	1.2	2.6	4.5	0.9	2.1
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.5	1.8	1.1	1.3
Had major operations	1.2	1.4	2.8	0.2	-1.7
Medication: Atenolol	1.1	1.4	2.5	-0.6	-1.6
Fluid intelligence score	1.1	2.2	4.3	-2.1	0.3
Trunk fat-free mass	1.1	6.5	8.9	2.0	3.0
Pulse wave reflection index	1.1	1.4	2.2	-1.5	0.7
Gout (self-reported)	1.1	1.5	2.9	0.0	-1.7
Qualifications: College or University degree	1.1	3.5	6.9	-0.0	2.6
Number of full sisters	1.1	1.3	1.7	-0.9	-1.3
Smoking status: Previous	1.1	1.7	3.3	0.1	-1.8
Medication for cholesterol	1.1	1.6	2.5	0.9	1.6
Number of self-reported non-cancer illnesses	1.1	2.0	3.6	0.6	-1.9
Diastolic blood pressure, automated reading	1.1	3.3	4.0	-1.6	-2.0
Unable to work because of sickness or disability	1.1	1.4	1.6	1.2	1.1
Pain experienced in last month	1.1	1.8	3.6	-0.1	1.9
Verbal and Numeric Reasoning (VNR)	1.0	2.4	4.7	-0.3	2.2
Bipolar Disorder (2011)	1.0	0.9	1.8	1.4	0.3
Waist Hip Ratio (WHR)	1.0	4.7	8.9	-0.7	-3.0
Hearing difficulty/problems: Yes	1.0	1.5	2.7	-1.6	-0.5
Medication: Co-codamol	1.0	1.2	1.3	-1.1	-1.1
Maternal smoking around birth	1.0	1.4	1.8	1.3	-1.0
Hayfever, allergic rhinitis or eczema	1.0	2.1	4.0	0.4	2.0
Impedance of leg (left)	1.0	4.7	8.9	-0.7	-3.0
Hair/balding pattern: Pattern 3	1.0	1.5	2.0	1.4	0.9
Mouth/teeth dental problems: Dentures	1.0	1.7	3.2	0.4	-1.8
Trunk predicted mass	1.0	5.9	8.2	1.9	2.9
Glaucoma (self-reported)	1.0	1.2	1.6	1.3	0.9
Chronic bronchitis/emphysema (mother)	1.0	1.2	2.0	-1.4	-0.7
Arm fat-free mass (right)	1.0	5.2	9.5	0.9	3.1
Leg pain on walking	1.0	1.2	1.3	1.1	-1.0
Whole body water mass	1.0	5.8	9.1	1.6	3.0
Average weekly beer plus cider intake	1.0	1.4	2.4	-0.7	-1.5
Heart disease (siblings)	1.0	1.2	2.3	-0.1	1.5
Impedance of whole body	1.0	5.1	10.0	-0.5	-3.2
Smoking Status	0.9	2.1	4.0	-0.5	-2.0
Lung FEV1/FVC ratio	0.9	4.5	7.6	1.2	2.8
Leg fat-free mass (left)	0.9	4.8	7.8	1.4	2.8
Chronic bronchitis/emphysema (father)	0.9	1.1	2.2	1.5	0.1
Leg predicted mass (left)	0.9	4.5	7.4	1.3	2.7
Illnesses of siblings	0.9	1.2	1.3	1.1	1.1
Noisy workplace	0.9	1.1	1.8	1.4	0.7
Tense / ‘highly strung’	0.9	1.5	3.0	1.7	-0.2
Blood clot in the leg (DVT)	0.9	1.1	2.2	-0.2	-1.5
High blood pressure (siblings)	0.9	1.2	1.4	-1.0	-1.2
Arm predicted mass (right)	0.9	4.7	8.8	0.7	3.0
Whole body fat-free mass	0.9	5.2	8.2	1.5	2.9
Commuting to job workplace: Walk	0.9	1.0	2.0	1.4	0.0
Vascular/heart problems diagnosed by doctor	0.9	2.6	4.5	0.8	2.1
Age at First Birth	0.8	1.1	1.6	-1.3	0.8
Sensitivity / hurt feelings	0.8	1.4	1.5	-1.2	-1.2
Impedance of leg (right)	0.8	3.8	7.6	-0.2	-2.7
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.7	2.2	1.1	1.5
Hip circumference	0.8	3.5	5.8	-1.1	2.4
Leg fat-free mass (right)	0.8	4.4	7.8	1.0	2.8
Eye problems/disorders: Cataract	0.8	0.9	1.1	-0.8	1.1
Leg predicted mass (right)	0.8	4.3	7.7	1.0	2.8
Average weekly champagne plus white wine intake	0.8	1.1	2.2	-1.5	0.0
Ever taken oral contraceptive pill	0.8	0.9	1.3	-1.1	0.8
Eye problems/disorders: Glaucoma	0.8	0.9	1.0	1.0	0.9
Medication: Paracetamol	0.8	1.2	2.4	0.4	-1.5
Basal metabolic rate	0.8	4.6	7.7	1.2	2.8
Arm fat-free mass (left)	0.8	4.0	7.3	0.9	2.7
Arm predicted mass (left)	0.8	4.0	7.2	0.9	2.7
Height	0.7	14.3	25.1	5.0	1.8
Respiratory disease	0.7	1.5	1.9	1.4	1.0
Number of treatments/medications taken	0.7	1.2	2.3	1.5	-0.1
Diabetes (mother)	0.7	1.0	1.2	-1.1	-0.8
Taking other prescription medications	0.7	1.1	2.2	1.5	-0.1
Hearing difficulty/problems with background noise	0.7	1.2	2.0	-1.4	-0.6
Alcohol intake versus 10 years previously	0.7	1.0	1.4	0.7	1.2
Impedance of arm (left)	0.7	3.4	6.8	-0.2	-2.6
Eye problems/disorders: None of the above	0.7	0.8	1.6	1.3	-0.2
Mouth/teeth dental problems: Loose teeth	0.7	0.8	1.6	1.2	-0.0
Emphysema/chronic bronchitis	0.7	0.8	1.2	0.7	-1.1
Migraine (self-reported)	0.7	0.8	0.8	0.9	-0.9
Knee pain experienced in last month	0.7	1.1	2.0	0.5	1.4
Worry (Nagel 2018)	0.6	1.3	1.9	1.4	-0.8
Irritable Bowel Disease (IBD)	0.6	1.3	1.6	1.0	1.3
Ovarian Cancer	0.6	0.8	1.4	1.2	-0.4
Frequency of depressed mood in last 2 weeks	0.6	0.9	1.4	0.6	1.2
Medication for hormone replacement therapy	0.6	0.6	0.9	-0.6	-1.0
Current tobacco smoking	0.6	1.0	1.2	-0.9	-1.1
Forced expiratory volume in 1-second (FEV1)	0.6	1.9	2.3	1.2	1.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.9	3.0	0.9	1.7
Standing height	0.6	6.3	11.0	3.3	1.3
Smoking status: Current	0.6	0.9	1.0	-0.9	-1.0
Supplements: Fish oil (including cod liver oil)	0.6	0.7	1.1	-1.1	-0.6
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	1.6	0.1	-1.3
Bipolar Disorder (2018)	0.5	0.8	1.6	1.3	0.3
Ulcerative Colitis (UC)	0.5	0.9	1.6	1.2	0.4
Ever had hysterectomy (womb removed)	0.5	0.6	1.1	-0.2	1.1
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	1.0	-0.3	-1.0
Body mass index (BMI)	0.5	2.3	3.1	-1.8	1.2
Forced vital capacity (FVC)	0.5	1.8	2.9	1.7	0.9
Medication: Ramipril	0.5	0.6	0.7	0.9	-0.7
Hair/balding pattern: Pattern 4	0.5	1.1	1.5	0.8	-1.2
Number of children fathered	0.5	0.6	1.1	-0.3	-1.0
Family relationship satisfaction	0.5	0.6	1.1	-0.4	1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.2	0.2	-1.1
Guilty feelings	0.5	0.8	1.4	1.2	-0.5
Medication: Atorvastatin	0.5	0.6	1.0	1.0	-0.4
Ever smoked	0.5	0.8	1.2	-0.7	-1.1
Leg fat percentage (left)	0.5	1.7	3.5	-1.9	-0.1
Number of operations (self-reported)	0.5	0.7	0.9	0.9	-0.8
Fractured/broken bones in last 5 years	0.5	0.6	0.8	-0.7	0.9
Commuting to job workplace: Cycle	0.5	0.6	1.1	0.2	1.1
Depressed Affect (Nagel 2018)	0.4	0.9	1.7	1.3	0.4
Alzheimer’s Disease (in mother)	0.4	0.4	0.7	0.4	-0.9
Mean Putamen Volume	0.4	0.4	0.7	-0.3	-0.9
BMI	0.4	2.5	2.9	-1.4	1.7
Average weekly spirits intake	0.4	0.5	0.6	-0.8	-0.6
Trunk fat percentage	0.4	1.7	3.3	-1.8	-0.5
Stomach or abdominal pain in last month	0.4	0.4	0.8	-0.9	-0.3
High blood pressure (mother)	0.4	0.5	0.5	0.7	0.7
Nervous feelings	0.4	0.8	1.2	0.6	-1.1
Allergy	0.4	0.9	1.7	-0.2	-1.3
Medication: Allopurinol	0.4	0.5	0.7	0.5	-0.9
Arm fat percentage (left)	0.4	1.4	2.8	-1.7	0.3
Osteoporosis (self-reported)	0.4	0.4	0.8	0.3	0.9
Irritability	0.4	0.7	0.7	-0.8	-0.8
Basal cell carcinoma (self-reported)	0.4	0.5	0.7	0.6	0.8
Alzheimer’s Disease (in father)	0.3	0.3	0.6	0.2	0.8
Body Mass Index (BMI) (2010)	0.3	0.4	0.5	0.6	0.7
Crohns Disease (2012)	0.3	0.5	0.9	-0.9	0.3
Fasting Glucose	0.3	0.4	0.5	0.5	0.7
Primary Biliary Cirrhosis	0.3	0.4	0.8	-0.9	-0.2
Lung FVC	0.3	1.4	2.3	-0.6	1.5
Relative age of first facial hair	0.3	0.6	1.1	-0.4	-1.1
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.9	0.1	-0.9
Fed-up feelings	0.3	0.5	0.7	0.5	0.8
Serious illness, injury or assault to yourself	0.3	0.3	0.5	-0.4	0.7
High blood pressure	0.3	1.0	1.8	-0.3	-1.4
Supplements: Glucosamine	0.3	0.4	0.7	-0.8	0.4
Sitting height	0.3	1.8	2.6	1.6	1.0
Alcohol usually taken with meals	0.3	0.4	0.6	0.5	0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.3	0.2	1.1
Heart attack	0.3	0.4	0.4	-0.7	-0.5
Weight	0.3	1.5	3.0	-0.2	1.7
Arm fat percentage (right)	0.3	1.2	2.4	-1.6	-0.1
Father’s age at death	0.3	0.4	0.7	-0.3	0.8
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.4	-0.6	-0.5
Arm fat mass (right)	0.3	1.1	1.2	-1.0	1.1
Ever highly irritable/argumentative for 2 days	0.3	0.3	0.4	0.5	0.6
Body fat percentage	0.3	1.2	2.4	-1.5	-0.2
Leg fat percentage (right)	0.3	1.1	2.2	-1.5	-0.0
Health satisfaction	0.3	0.5	0.7	0.8	0.4
Neck or shoulder pain in last month	0.3	0.4	0.8	-0.1	0.9
Angina (self-reported)	0.3	0.4	0.8	-0.9	-0.3
Medication: Aspirin	0.3	0.3	0.6	0.3	-0.8
Hypertension (Self-reported)	0.3	0.8	1.6	-0.1	-1.3
Friendships satisfaction	0.3	0.4	0.7	0.3	0.9
Qualifications: nursing, teaching	0.3	0.5	0.7	-0.8	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.3	-0.1	1.1
Arm fat mass (left)	0.3	1.2	1.2	-1.1	1.1
Miserableness	0.3	0.5	0.9	0.9	-0.3
Alcohol drinker status: Never	0.3	0.4	0.8	0.1	-0.9
Age started oral contraceptive pill	0.3	0.4	0.7	-0.8	0.4
Myopia	0.3	0.4	0.6	-0.4	-0.7
Heart attack/myocardial infarction (self-reported)	0.3	0.3	0.4	-0.6	-0.5
Intelligence (Savage-Jansen 2018)	0.2	0.7	0.9	-0.9	0.7
Schizophrenia vs Biploar Disorder	0.2	0.2	0.3	0.4	-0.5
Crohns Disease (2017)	0.2	0.5	0.9	-0.3	0.9
Allergy or Eczema	0.2	0.6	1.0	0.5	1.0
Neuroticism	0.2	0.6	0.8	0.9	-0.6
Tanning	0.2	3.0	5.2	-2.3	0.9
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.6	-0.0	0.8
Angina	0.2	0.3	0.3	-0.5	-0.5
Average weekly fortified wine intake	0.2	0.3	0.4	-0.6	-0.4
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	0.4	0.7	0.3
Waist circumference	0.2	0.7	1.0	-1.0	0.6
Financial difficulties in last 2 years	0.2	0.2	0.5	0.1	-0.7
Neuroticism score	0.2	0.4	0.8	0.9	-0.3
Time employed in main current job	0.2	0.2	0.2	0.5	0.4
Pulse rate	0.2	0.3	0.6	-0.8	-0.2
Length of working week for main job	0.2	0.3	0.5	-0.2	0.7
Loud music exposure frequency	0.2	0.2	0.2	-0.4	0.5
Forced vital capacity (FVC), Best measure	0.2	0.7	1.3	1.1	0.4
Leg fat mass (right)	0.2	0.6	1.2	-0.2	1.1
Average weekly red wine intake	0.2	0.2	0.5	0.7	0.2
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.5	0.7	0.1
Medication: Aspirin	0.2	0.3	0.5	0.3	-0.7
Wears glasses or contact lenses	0.2	0.2	0.4	0.6	0.4
Leg fat mass (left)	0.2	0.7	0.9	-0.7	0.9
Neuroticism (Nagel 2018)	0.1	0.3	0.4	0.4	-0.6
Ulcerative Colitis	0.1	0.2	0.3	0.2	-0.6
Chronotype (morning person)	0.1	0.3	0.6	-0.1	-0.8
Hand grip strength (left)	0.1	0.3	0.4	0.7	-0.3
Diabetes (father)	0.1	0.2	0.3	-0.6	-0.1
Hand grip strength (right)	0.1	0.3	0.6	0.8	0.1
Townsend deprivation index at recruitment	0.1	0.2	0.3	0.2	0.5
Age when periods started (menarche)	0.1	0.3	0.5	0.7	-0.4
Trunk fat mass	0.1	0.4	0.7	-0.9	0.2
Hair/balding pattern: Pattern 2	0.1	0.1	0.2	-0.5	-0.1
Had menopause	0.1	0.1	0.1	-0.2	-0.3
Had other major operations	0.1	0.1	0.3	0.1	0.5
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.2	-0.4	0.5
Lung cancer (father)	0.1	0.1	0.2	0.4	-0.3
Peak expiratory flow (PEF)	0.1	0.2	0.4	-0.6	0.0
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.4	-0.6	-0.2
Medication: Amlodipine	0.1	0.2	0.2	-0.4	-0.5
Wheeze or whistling in the chest in last year	0.1	0.2	0.3	0.5	0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.2	0.2	0.5
Whole body fat mass	0.1	0.6	0.7	-0.8	0.7
Illness, injury, bereavement, stress in last 2 years	0.1	0.2	0.3	0.5	0.3
Supplements: Vitamin C	0.1	0.1	0.2	0.5	0.3
Illnesses of father: Heart disease	0.1	0.1	0.3	-0.5	0.0
Loneliness, isolation	0.1	0.1	0.2	0.5	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.2	-0.5	-0.3
Mineral and other dietary supplements	0.1	0.1	0.2	0.2	-0.5
Osteoarthritis (self-reported)	0.1	0.2	0.4	-0.6	-0.0
Medication: Gliclazide	0.1	0.1	0.2	-0.4	0.1
Commuting to job workplace: Public transport	0.1	0.2	0.2	-0.3	-0.5
Medication: Blood pressure	0.1	0.1	0.1	0.4	-0.3
Pain type(s) experienced in last month: Hip pain	0.1	0.2	0.4	0.6	-0.1
Medication: Bendroflumethiazide	0.1	0.2	0.4	-0.6	-0.3
Medication: Lisinopril	0.1	0.1	0.1	0.3	0.1
Alzheimer’s Disease (including proxy)	0.0	0.0	0.0	0.0	-0.0
Breast Cancer	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0
HbA1C	0.0	0.0	0.1	0.3	-0.1
Hair Pigment	0.0	0.1	0.1	0.1	-0.4
Pain all over the body in last month	0.0	0.1	0.1	-0.2	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.0	0.1	0.1	-0.2	-0.3
Overall health rating	0.0	0.1	0.1	0.3	-0.2
Commuting to job workplace: Car/motor vehicle	0.0	0.0	0.0	-0.0	-0.0
Long-standing illness, disability or infirmity	0.0	0.0	0.0	0.0	0.1
Mouth/teeth dental problems: Mouth ulcers	0.0	0.0	0.0	-0.1	0.1
Back pain experienced in last month	0.0	0.0	0.0	0.0	0.2
Breast cancer (self-reported)	0.0	0.0	0.0	0.1	-0.1
Financial situation satisfaction	0.0	0.0	0.1	0.2	0.2

Hub : Genes

TCTN1

Models

Trait associations