TWAS hub - TCHP

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	NTR	Blood	0.0120	0.0057	0.00620	0.003	0.003	0.001	0.003	0.003	0.043	0.0420	0.1700	0.032	0.026
2	TCGA	Lung Squamous Cell Carcinoma	0.0694	0.0335	0.00032	0.007	0.014	0.021	NA	0.004	0.048	0.0080	0.0018	NA	0.110
3	TCGA	Thyroid Carcinoma	0.0490	0.0280	0.00110	0.009	0.026	0.017	NA	0.014	0.042	0.0014	0.0079	NA	0.013

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Hypothyroidism (self reported)	10.1	23.3	36.0	-6.0	-4.6	-3.6
Hypothyroidism/myxoedema (self-reported)	9.6	18.8	30.7	-5.5	-4.2	-2.8
Schizophrenia (2018)	7.0	14.5	20.5	-2.9	-4.5	-3.8
Coronary Artery Disease (CAD)	6.4	7.6	10.3	-3.2	-2.4	-2.7
Hypertension (Self-reported)	6.3	17.5	32.7	-3.7	-2.5	-5.7
High blood pressure	6.2	17.2	32.8	-3.5	-2.5	-5.7
Vascular/heart problems diagnosed by doctor	6.0	16.2	28.8	3.6	2.7	5.4
Cardiovascular Disease	5.9	19.4	30.3	-4.9	-2.1	-5.5
Medication: Levothyroxine sodium	5.5	9.4	13.8	-3.7	-3.5	-1.5
Schizophrenia (2014)	5.3	11.8	15.9	-2.5	-4.0	-3.6
Systolic Blood Pressure	5.2	26.0	40.1	-5.4	-2.9	-6.3
Major Depression (MDD)	5.1	6.2	8.8	-2.8	-3.0	-1.5
Systolic blood pressure, automated reading	5.0	14.6	24.8	-3.9	-1.9	-5.0
Medication: Ramipril	5.0	6.5	9.3	-2.3	-2.2	-3.0
Pain type(s) experienced in last month: Hip pain	5.0	6.3	8.9	-3.0	-1.7	-2.7
Number of live births	4.6	6.5	11.0	-3.3	-2.5	-1.5
Qualifications: None of the above	4.3	9.3	11.7	-3.4	-3.1	-2.5
Medication: Blood pressure	4.1	7.3	12.6	-2.1	-2.2	-3.5
Peak expiratory flow (PEF)	3.9	9.1	14.2	3.4	1.2	3.8
Number of self-reported non-cancer illnesses	3.9	6.7	10.5	-2.3	-2.1	-3.2
Medication: Atenolol	3.8	4.8	7.1	-2.7	-1.3	-2.4
Blood Eosinophil Count	3.7	28.2	44.0	-6.6	-2.8	-5.8
Illnesses of mother	3.7	4.5	6.8	2.6	1.9	1.7
Bipolar Disorder or Schizophrenia	3.6	8.8	14.8	-1.8	-3.8	-2.9
Medication for cholesterol, blood pressure or diabetes	3.4	5.7	10.5	1.8	1.8	3.2
Triglycerides	3.3	5.4	7.8	-2.8	-1.6	-2.4
Mother’s age at death	3.3	4.1	4.8	2.2	1.7	2.1
Verbal and Numeric Reasoning (VNR)	3.2	7.8	10.9	2.4	3.3	2.5
Medication: Paracetamol	3.2	5.0	10.7	-3.3	-2.0	-0.4
Headache pain in last month	3.1	5.3	9.2	-2.5	-3.0	0.7
Medication for cholesterol	3.1	4.6	8.1	2.8	0.4	2.4
Tinnitus: Yes, now most or all of the time	3.1	3.6	6.0	1.9	1.1	2.5
Lung FVC	3.0	15.0	24.4	4.9	2.4	3.9
Mouth/teeth dental problems	3.0	4.6	12.7	3.6	1.1	-0.1
Medication: Ibuprofen	2.9	3.5	7.8	0.8	1.4	2.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.9	6.1	11.2	2.5	1.0	3.3
Fluid intelligence score	2.8	5.9	9.5	1.9	3.1	2.2
Birth weight	2.8	6.0	9.5	3.1	0.2	2.9
Maternal smoking around birth	2.7	3.9	5.7	-2.3	-2.4	-0.8
Age at first live birth	2.7	4.8	9.5	3.1	2.0	0.8
Leg pain on walking	2.7	3.3	4.7	-2.1	-2.2	-1.0
Taking other prescription medications	2.6	4.1	5.7	-1.9	-1.8	-2.4
Medication: Ibuprofen (e.g. Nurofen)	2.6	3.3	7.2	1.3	1.0	2.7
Medication: Paracetamol	2.6	4.3	8.9	-3.0	-1.9	-0.4
Diastolic blood pressure, automated reading	2.6	8.0	17.2	-2.4	-1.0	-4.2
Tinnitus: Yes, but not now, but have in the past	2.5	2.7	5.4	-0.3	-1.6	-2.3
Medication: Blood pressure	2.5	4.7	8.2	-2.3	-0.7	-2.9
Serious illness, injury or assault of a close relative in last 2 years	2.4	2.8	5.7	-1.3	-0.9	-2.4
Supplements: Fish oil (including cod liver oil)	2.4	3.2	4.0	1.9	2.0	1.4
Alcohol usually taken with meals	2.3	3.8	5.8	2.3	0.5	2.4
Worry (Nagel 2018)	2.2	4.6	10.8	-3.3	-1.7	-0.5
Illnesses of siblings	2.2	3.1	4.4	1.8	1.2	2.1
Heart disease (mother)	2.2	2.6	4.5	-2.1	-1.1	-1.5
Mineral and other dietary supplements	2.2	2.9	3.1	-1.8	-1.8	-1.6
Hearing aid user	2.2	2.4	5.4	-0.3	1.4	2.3
Age at First Birth	2.1	3.0	5.3	2.3	1.8	0.8
Forced expiratory volume in 1-second (FEV1)	2.1	7.2	12.9	2.8	0.9	3.6
Medication: Allopurinol	2.1	2.8	7.6	-0.5	-0.8	-2.8
Had major operations	2.1	2.4	3.2	-1.8	-1.8	-1.0
Medication: Aspirin	2.1	2.8	3.4	-1.5	-1.8	-1.7
Number of treatments/medications taken	2.0	3.6	4.7	-2.2	-2.0	-1.4
Impedance of leg (right)	2.0	9.8	12.3	-3.5	-3.3	-2.5
Impedance of leg (left)	2.0	9.8	12.2	-3.5	-3.3	-2.6
Nervous feelings	2.0	3.6	7.3	-2.7	-1.7	-0.8
Neuroticism (2016)	1.9	2.7	4.2	-2.0	-2.0	-0.2
Prospective memory result	1.9	2.4	5.2	-1.1	-2.3	-0.9
Birth weight of first child	1.9	3.5	5.6	1.9	1.1	2.4
Exposure to tobacco smoke outside home	1.9	2.5	5.3	-2.3	-1.1	1.0
Smoking status: Previous	1.9	2.9	4.5	-2.1	-1.0	-1.8
Mouth/teeth dental problems: Bleeding gums	1.8	2.3	5.2	-2.3	1.1	0.7
Migraine (self-reported)	1.8	2.2	3.7	-1.7	-1.9	-0.2
Medication: Aspirin	1.8	2.3	2.9	-1.4	-1.7	-1.4
Hearing difficulty/problems: Yes	1.7	2.6	4.3	0.3	2.1	1.8
Qualifications: A levels/AS levels or equivalent	1.7	3.9	5.5	2.3	2.0	1.4
Pulse wave reflection index	1.7	2.1	3.0	1.1	1.7	1.4
High blood pressure (siblings)	1.7	2.4	4.0	-1.6	-0.9	-2.0
Comparative body size at age 10	1.7	4.7	9.9	1.1	3.1	1.7
Pulse wave peak to peak time	1.7	2.0	4.8	-0.5	-2.2	-1.0
High blood pressure (mother)	1.6	2.2	4.5	-1.4	-0.4	-2.1
Worrier / anxious feelings	1.6	3.1	5.9	-2.4	-1.9	-0.0
Qualifications: O levels/GCSEs or equivalent	1.6	2.5	4.0	1.4	2.0	1.3
Cholesterol lowering medication	1.6	2.3	6.5	-2.5	-0.1	-0.7
Pain experienced in last month	1.6	2.7	6.8	2.6	1.0	-0.5
Impedance of whole body	1.6	8.2	10.1	-3.2	-2.7	-2.7
Respiratory disease	1.5	3.3	4.9	-2.2	-1.4	-1.7
Number of incorrect matches in round	1.5	2.5	4.3	-0.6	-2.1	-1.6
Lung cancer (father)	1.5	1.8	2.4	-1.3	-1.1	-1.6
Illnesses of father: None of the above (group 1)	1.5	1.8	5.1	2.3	0.1	0.5
Medication: Atorvastatin	1.5	1.9	3.2	-1.8	-1.4	-0.8
Intelligence (Savage-Jansen 2018)	1.4	4.2	7.2	1.2	2.7	1.9
Fasting Glucose	1.4	1.7	2.7	-0.7	-1.7	-1.4
Mouth/teeth dental problems: Dentures	1.4	2.4	4.9	-2.2	-1.5	-0.2
Pulse wave Arterial Stiffness index	1.4	1.6	3.8	0.5	1.9	1.0
Gout (self-reported)	1.4	1.9	4.7	0.1	-1.0	-2.2
Medication for pain relief, constipation, heartburn	1.4	2.4	4.3	2.1	1.6	0.2
Diabetes diagnosed by doctor	1.4	2.3	4.9	-1.1	-0.9	-2.2
Serious illness, injury or assault to yourself	1.3	1.6	1.7	1.3	1.2	1.3
Medication: Simvastatin	1.3	1.8	2.8	-1.6	0.3	-1.7
Forced expiratory volume in 1-second (FEV1), Best measure	1.3	4.0	8.1	1.8	0.9	2.8
Qualifications: College or University degree	1.3	4.0	6.0	2.4	2.1	1.2
Neck or shoulder pain in last month	1.3	1.8	5.3	-0.1	0.2	2.3
Chronotype (morning person)	1.2	2.9	5.5	-2.3	-1.2	-1.3
Qualifications: nursing, teaching	1.2	1.9	2.9	1.1	1.7	1.2
Wears glasses or contact lenses	1.2	1.4	2.7	1.6	1.0	0.6
Illnesses of father: High blood pressure	1.2	1.5	4.0	-2.0	-0.6	-0.5
Basal cell carcinoma (self-reported)	1.2	1.4	2.3	1.5	0.7	1.2
Ulcerative Colitis	1.1	1.7	3.4	-1.1	-0.7	-1.8
Stomach or abdominal pain in last month	1.1	1.4	3.5	0.1	0.9	1.9
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	2.8	1.7	0.1	1.1
Father’s age at death	1.1	1.5	3.4	0.6	0.8	1.8
Medication: Lansoprazole	1.1	1.3	2.1	-1.3	0.1	-1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.5	3.1	1.8	0.7	0.9
Average weekly beer plus cider intake	1.1	1.5	3.6	-1.9	-0.5	-0.9
Risk taking	1.1	1.6	2.9	1.1	1.7	0.8
Fractured/broken bones in last 5 years	1.1	1.4	2.1	1.0	1.1	1.4
Commuting to job workplace: Cycle	1.1	1.3	3.0	1.7	0.9	0.3
Heart attack/myocardial infarction (self-reported)	1.1	1.5	2.2	-1.5	-1.2	-0.9
Schizophrenia vs Biploar Disorder	1.0	1.3	2.4	-1.2	-0.3	-1.6
Alzheimer’s Disease (in mother)	1.0	1.2	2.2	-1.5	-1.1	-0.4
Ulcerative Colitis (UC)	1.0	1.8	4.2	-0.9	-0.6	-2.0
Type 2 Diabetes (T2D) (2018)	1.0	1.8	4.4	-0.9	-0.4	-2.1
Neuroticism	1.0	2.5	7.1	-2.7	-0.7	0.2
Sensitivity / hurt feelings	1.0	1.7	5.0	-2.2	0.2	0.2
Forced vital capacity (FVC)	1.0	3.8	7.2	2.1	0.0	2.7
Financial difficulties in last 2 years	1.0	1.4	1.9	-1.1	-1.0	-1.4
Heart attack	1.0	1.3	2.2	-1.5	-1.1	-0.8
Breastfed as a baby	1.0	1.2	3.4	1.9	-0.5	-0.2
Chest pain or discomfort	1.0	1.4	2.4	-1.6	-1.3	-0.1
Back pain experienced in last month	1.0	1.4	4.2	-2.0	-0.4	0.0
Supplements: Calcium	1.0	1.2	1.4	0.8	1.2	1.2
Alcohol drinker status: Previous	1.0	1.2	1.4	-1.0	-1.2	-1.1
Neuroticism (Nagel 2018)	0.9	2.2	5.9	-2.4	-0.3	0.8
Angina	0.9	1.2	2.8	-0.8	-1.7	-0.4
Hand grip strength (right)	0.9	2.4	3.5	-0.8	-1.8	-1.9
Supplements: Glucosamine	0.9	1.2	2.0	1.3	1.4	0.0
Diabetes (self-reported)	0.9	1.4	3.9	-0.5	-0.3	-2.0
Impedance of arm (right)	0.9	4.4	5.2	-2.2	-2.3	-1.8
Medication: Cholesterol lowering	0.9	1.5	2.6	-1.2	-0.6	-1.6
Worry too long after embarrassment	0.9	1.5	3.0	-1.1	0.6	1.7
Number of children fathered	0.9	1.0	2.1	-1.0	-1.4	0.1
Mouth/teeth dental problems: Loose teeth	0.9	1.0	1.5	-1.2	-1.2	0.1
Emphysema/chronic bronchitis	0.9	1.0	1.6	-1.1	-0.4	1.3
Pulse rate, automated reading	0.9	2.9	5.9	-2.4	-1.1	1.2
Overall health rating	0.9	1.8	3.3	-1.8	-0.5	-1.4
Medication: Bendroflumethiazide	0.9	1.4	3.2	-0.9	0.4	-1.8
Crohns Disease (2012)	0.8	1.2	3.0	0.4	1.7	0.7
HDL Cholesterol	0.8	1.4	2.6	-1.6	1.2	0.4
LDL Cholesterol	0.8	1.2	3.2	-1.8	-0.7	0.2
Lupus	0.8	1.2	2.5	-1.1	-0.1	-1.6
Primary Biliary Cirrhosis	0.8	1.2	2.4	1.5	1.0	0.5
BMI	0.8	4.5	11.8	1.2	3.4	0.6
Waist Hip Ratio (WHR)	0.8	3.4	5.7	-2.4	-1.6	-1.4
Ever used hormone-replacement therapy (HRT)	0.8	1.0	1.4	-1.2	-0.6	-1.2
Qualifications: CSEs or equivalent	0.8	1.0	2.4	-0.2	0.7	1.6
Multivitamins +/- minerals	0.8	1.0	1.9	1.4	0.7	0.8
Hair/balding pattern: Pattern 2	0.8	1.0	2.9	1.7	0.0	0.4
Impedance of arm (left)	0.8	3.7	4.0	-2.0	-1.8	-2.0
Shortness of breath walking on level ground	0.8	1.0	1.7	0.3	1.3	1.1
Number of full sisters	0.8	1.0	2.2	-0.7	-0.4	-1.5
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	1.9	0.6	0.8	1.4
Medication: Gliclazide	0.8	0.9	2.5	-0.4	0.3	-1.6
HbA1C	0.7	0.8	1.8	-1.3	-0.6	0.4
Blood Platelet Count	0.7	7.9	10.6	-2.7	3.3	-2.4
Average weekly spirits intake	0.7	0.9	2.3	-0.6	-0.2	-1.5
Vitamin and mineral supplements	0.7	1.0	2.2	-0.8	-0.4	-1.5
Body mass index (BMI)	0.7	2.9	7.6	0.3	2.8	1.0
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.2	2.4	-1.5	1.0	0.4
Falls in the last year	0.7	1.0	2.6	0.4	1.6	-0.3
Glaucoma (self-reported)	0.7	0.8	2.1	-0.1	-1.4	-0.4
Chronic bronchitis/emphysema (mother)	0.7	0.8	1.2	0.4	1.1	1.1
Eye problems/disorders: Glaucoma	0.7	0.8	1.4	-0.1	-1.2	-1.1
Pack years of smoking	0.7	1.1	2.0	-0.8	-1.4	0.7
Lung FEV1/FVC ratio	0.6	2.8	7.3	0.6	0.8	2.7
Relative age of first facial hair	0.6	1.3	2.0	-1.1	-0.8	-1.4
Supplements: Zinc	0.6	0.6	1.6	1.3	0.4	0.2
Pack years adult smoking proportion	0.6	0.9	1.5	-0.7	-1.2	0.9
Chronic bronchitis/emphysema (father)	0.6	0.7	1.9	-1.4	-0.3	-0.0
Past tobacco smoking	0.6	1.1	2.0	1.4	0.3	1.0
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	1.4	1.2	-0.4	-1.0
Neuroticism score	0.6	1.3	3.4	-1.8	-0.7	-0.1
Hip circumference	0.6	2.7	6.9	0.1	2.6	1.1
Noisy workplace	0.6	0.7	1.7	-0.6	-1.3	0.2
Forced vital capacity (FVC), Best measure	0.6	2.1	4.9	1.2	-0.1	2.2
Angina (self-reported)	0.6	0.7	1.6	-0.8	-1.3	-0.2
Comparative height size at age 10	0.6	3.3	8.2	0.2	-2.9	-1.4
Family relationship satisfaction	0.6	0.7	1.5	1.2	0.6	0.5
Supplements: Vitamin C	0.6	0.7	1.5	-0.5	0.6	1.2
Knee pain experienced in last month	0.6	0.9	2.2	0.1	1.5	-0.6
Illnesses of siblings: Diabetes	0.6	0.7	0.9	-1.0	-1.0	-0.5
Leg fat-free mass (right)	0.6	3.0	3.1	1.8	1.8	1.7
Osteoarthritis (self-reported)	0.6	0.7	2.0	0.1	0.4	-1.4
Leg predicted mass (right)	0.6	3.1	3.2	1.8	1.8	1.7
Miserableness	0.6	1.1	2.3	-1.5	-0.8	-0.6
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.5	1.2	0.4	0.6
Crohns Disease (2017)	0.5	1.0	2.5	0.6	1.6	0.6
Body Mass Index (BMI) (2010)	0.5	0.6	0.9	1.0	0.9	-0.2
Blood White Count	0.5	4.1	10.9	-3.3	-0.2	-1.1
Heel T-Score	0.5	3.6	10.6	-0.1	-0.4	-3.3
Medication for hormone replacement therapy	0.5	0.6	0.9	-1.0	0.2	-0.9
Diabetes (father)	0.5	0.6	1.0	-1.0	0.3	-0.9
Leg fat-free mass (left)	0.5	2.4	2.7	1.5	1.6	1.6
Leg predicted mass (left)	0.5	2.5	2.7	1.5	1.6	1.6
Had menopause	0.5	0.7	1.4	-0.7	0.3	-1.2
Hair/balding pattern: Pattern 3	0.5	0.8	1.5	-0.9	-0.4	-1.2
Tense / ‘highly strung’	0.5	0.8	1.2	-1.1	-0.9	-0.7
Blood clot in the leg (DVT)	0.5	0.6	1.7	-0.1	-1.3	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.1	-0.8	-0.3	-1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	2.3	-0.7	-1.5	0.5
Ever had bowel cancer screening	0.5	0.6	1.5	-0.1	-1.2	-0.6
Ever taken oral contraceptive pill	0.5	0.5	1.2	0.6	1.1	0.0
High cholesterol (Self-reported)	0.5	1.0	1.8	-1.4	0.0	-1.0
Alcohol drinker status: Never	0.5	0.5	1.0	0.1	-1.0	0.8
Myopia	0.5	0.8	1.1	0.9	0.6	1.0
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.7	-0.2	-1.3	-0.4
Alzheimer’s Disease (in father)	0.4	0.5	1.0	0.3	0.5	-1.0
Alzheimer’s Disease (including proxy)	0.4	0.6	0.9	-0.9	-0.1	-0.9
Smoking Status	0.4	0.9	2.3	-1.5	-0.0	-0.7
Hand grip strength (left)	0.4	1.1	1.9	0.3	-1.4	-1.2
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	0.7	-0.8	-0.8	0.1
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	0.8	-0.8	0.8	0.9
Happiness	0.4	0.4	1.2	1.1	0.2	0.3
Depression (self-reported)	0.4	0.5	0.8	0.9	0.7	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.7	1.0	0.4	-0.9	-1.0
Hair/balding pattern: Pattern 4	0.4	1.1	1.6	-1.1	-1.3	0.5
Medication: Amlodipine	0.4	0.6	1.6	-0.2	-0.3	-1.3
Leg fat percentage (right)	0.4	1.3	2.3	-1.5	1.2	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.0	-0.7	-1.0	-0.1
Illnesses of father: Heart disease	0.4	0.6	1.5	-1.2	0.4	0.1
Friendships satisfaction	0.4	0.5	1.0	1.0	0.6	0.4
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.8	-1.3	-0.0	-0.3
Asthma (self-reported)	0.4	0.7	1.6	-0.6	-0.4	-1.3
Depressed Affect (Nagel 2018)	0.3	0.7	1.0	-1.0	-0.4	1.0
Irritable Bowel Disease (IBD)	0.3	0.6	1.5	-0.1	0.6	-1.2
Reaction Time	0.3	0.5	1.3	-0.3	-0.3	-1.2
Height	0.3	6.5	13.8	-2.1	-3.7	-1.1
Diabetes (mother)	0.3	0.3	0.7	-0.8	-0.6	-0.0
Severe depression (siblings)	0.3	0.4	0.9	0.9	0.3	0.4
Trunk fat percentage	0.3	1.1	1.8	-1.4	1.1	-0.3
Current tobacco smoking	0.3	0.5	1.1	-0.0	0.5	1.1
Hearing difficulty/problems with background noise	0.3	0.5	1.1	-1.1	0.3	-0.5
Pain all over the body in last month	0.3	0.4	0.7	-0.5	0.3	0.8
Alcohol intake versus 10 years previously	0.3	0.5	1.0	0.5	1.0	0.4
Pulse rate	0.3	0.4	1.2	-1.1	0.2	0.1
Arm fat mass (right)	0.3	1.3	3.5	-0.2	1.9	0.6
Body fat percentage	0.3	1.3	2.4	-1.5	1.0	-0.5
Arm fat-free mass (right)	0.3	1.3	1.8	1.0	1.1	1.3
Number of full brothers	0.3	0.3	0.8	0.1	-0.4	0.9
Mean time to correctly identify matches	0.3	0.6	0.9	-0.4	-0.8	-1.0
Arm predicted mass (right)	0.3	1.4	1.9	1.0	1.1	1.4
Suffer from ‘nerves’	0.3	0.5	0.9	-0.9	-0.3	-0.8
Age at last live birth	0.3	0.4	1.0	0.5	-0.2	-1.0
Whole body fat-free mass	0.3	1.9	2.9	1.3	1.1	1.7
Arm fat percentage (left)	0.3	1.3	3.5	-0.7	1.9	0.1
Handedness (chirality/laterality): Left-handed	0.3	0.3	0.7	0.2	-0.5	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.7	-0.8	-0.3	-0.4
Eye problems/disorders: Cataract	0.3	0.4	0.7	0.7	0.8	0.2
Whole body water mass	0.3	2.0	2.7	1.4	1.1	1.7
Arm fat mass (left)	0.3	1.4	3.8	-0.2	2.0	0.6
Average weekly champagne plus white wine intake	0.3	0.4	0.7	-0.0	0.8	0.8
Guilty feelings	0.3	0.5	1.1	-1.1	-0.5	-0.4
Basal metabolic rate	0.3	1.6	2.2	1.0	1.2	1.5
Leg fat percentage (left)	0.3	1.2	2.1	-1.4	1.2	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.7	-0.8	0.1	-0.6
Bipolar Disorder (2018)	0.2	0.3	0.7	0.8	-0.6	0.1
Depression (Nagel 2018)	0.2	0.3	0.7	-0.0	0.3	0.8
Ovarian Cancer	0.2	0.3	0.4	-0.3	-0.7	-0.5
Mean Putamen Volume	0.2	0.3	0.3	0.5	0.5	0.6
Rheumatoid Arthritis	0.2	0.3	0.5	-0.7	-0.6	0.2
Tanning	0.2	2.5	5.5	2.3	1.4	-0.0
Ever had hysterectomy (womb removed)	0.2	0.2	0.6	-0.0	0.4	0.7
Medication: Co-codamol	0.2	0.2	0.5	-0.7	-0.1	0.3
Medication: Metformin	0.2	0.3	0.7	-0.5	-0.1	-0.9
Fed-up feelings	0.2	0.4	0.5	-0.7	-0.2	0.7
Hayfever, allergic rhinitis or eczema	0.2	0.3	0.7	0.2	0.8	-0.5
Trunk fat mass	0.2	0.7	1.0	-1.0	1.0	0.2
Waist circumference	0.2	0.6	1.2	-0.8	1.1	-0.0
Had other major operations	0.2	0.3	0.3	0.6	0.6	-0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	0.7	0.8	0.2	-0.6
Allergy	0.2	0.5	0.8	0.9	-0.1	0.8
Weight	0.2	1.2	2.5	-0.1	1.6	1.0
Arm fat percentage (right)	0.2	1.0	2.2	-0.8	1.5	0.0
Trunk fat-free mass	0.2	1.3	2.2	1.2	0.5	1.5
Time employed in main current job	0.2	0.2	0.6	-0.1	-0.8	0.1
Asthma	0.2	0.4	1.1	-0.3	-0.0	-1.0
Trunk predicted mass	0.2	1.2	2.1	1.1	0.5	1.4
Standing height	0.2	1.6	4.3	-0.4	-2.1	0.5
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.3	-0.6	0.6	0.1
Loud music exposure frequency	0.2	0.2	0.4	-0.6	0.1	-0.3
Health satisfaction	0.2	0.3	0.4	-0.5	-0.4	0.7
Eye problems/disorders: None of the above	0.2	0.2	0.5	0.3	-0.1	0.7
Medication: Omeprazole	0.2	0.3	0.7	-0.4	0.8	0.1
Whole body fat mass	0.2	0.8	1.6	-0.8	1.3	0.2
Leg fat mass (right)	0.2	0.8	2.0	-0.3	1.4	0.4
Alcohol intake frequency.	0.2	0.5	0.9	0.3	-0.9	0.7
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.5	-0.7	-0.3	-0.4
Average weekly red wine intake	0.2	0.3	0.9	0.9	0.1	0.2
Mood swings	0.2	0.3	0.7	-0.8	-0.0	-0.6
Loneliness, isolation	0.2	0.2	0.5	0.4	-0.7	-0.0
Long-standing illness, disability or infirmity	0.2	0.3	0.9	-1.0	0.2	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.6	-0.8	0.0	0.4
Osteoporosis (self-reported)	0.2	0.2	0.3	0.6	0.5	0.1
Smoking status: Current	0.2	0.4	0.9	0.3	0.3	1.0
Arm fat-free mass (left)	0.2	0.9	1.5	0.6	0.9	1.2
Irritability	0.2	0.3	0.9	-0.9	0.2	0.0
Age started oral contraceptive pill	0.2	0.3	0.5	0.5	0.7	0.3
Heart disease (siblings)	0.2	0.2	0.4	-0.2	0.5	-0.6
Leg fat mass (left)	0.2	0.8	1.9	-0.5	1.4	0.5
Arm predicted mass (left)	0.2	1.1	1.7	0.7	1.0	1.3
Bipolar Disorder (2011)	0.1	0.1	0.3	0.5	0.0	0.0
Allergy or Eczema	0.1	0.4	0.7	-0.8	0.1	-0.6
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.2	0.4	0.4	0.2
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.4	-0.1	-0.2	-0.6
Average weekly fortified wine intake	0.1	0.2	0.4	0.6	0.1	0.2
Relative age voice broke	0.1	0.1	0.4	-0.1	-0.2	-0.6
Age when periods started (menarche)	0.1	0.3	0.4	-0.6	0.6	0.6
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.3	-0.5	0.1	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.5	0.7	-0.3	-0.5
Sitting height	0.1	0.8	2.1	1.4	-0.2	0.4
Ever unenthusiastic/disinterested for a whole week	0.1	0.2	0.4	-0.3	0.1	-0.6
Length of working week for main job	0.1	0.1	0.3	-0.1	0.4	-0.5
Exposure to tobacco smoke at home	0.1	0.1	0.2	-0.3	0.4	0.4
Wheeze or whistling in the chest in last year	0.1	0.2	0.4	-0.6	0.1	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.2	-0.0	0.4	-0.5
Medication: Seretide 50 evohaler	0.1	0.2	0.3	0.4	-0.6	0.0
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.3	0.5	0.1	0.3
Breast cancer (self-reported)	0.1	0.1	0.2	0.4	0.4	-0.3
Financial situation satisfaction	0.1	0.1	0.4	-0.1	-0.0	0.6
Commuting to job workplace: Public transport	0.1	0.1	0.2	-0.1	0.3	0.4
Medication: Lisinopril	0.1	0.1	0.2	0.2	0.4	-0.3
Ever smoked	0.1	0.2	0.6	-0.3	0.8	0.1
Number of operations (self-reported)	0.1	0.1	0.2	-0.4	-0.2	-0.2
Ever depressed for a whole week	0.1	0.1	0.2	0.3	0.1	-0.4
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.1	-0.1	-0.0	0.3
Blood Red Count	0.0	0.5	0.9	-0.7	1.0	-0.1
Hair Pigment	0.0	1.3	2.8	-1.7	-1.1	-0.3
Townsend deprivation index at recruitment	0.0	0.1	0.1	0.3	0.2	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.0	0.1	0.2	-0.0	0.1	0.4
Medication: Ventolin 100micrograms inhaler	0.0	0.1	0.2	-0.1	0.4	0.0
Commuting to job workplace: Walk	0.0	0.0	0.0	0.1	-0.0	0.1
Unable to work because of sickness or disability	0.0	0.0	0.1	0.3	-0.0	0.0

Hub : Genes

TCHP

Models

Trait associations