[Hub]/) : Traits : Forced vital capacity (FVC), Best measure : ← →

chr11:46,010,847-48,783,497

Best TWAS P=3.88e-15 · Best GWAS P=3.49e-13 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
68	ROSMAP	Brain Pre-frontal Cortex	C1QTNF4	0.05	0.06	blup	281	0.06	1.7e-08	-6.57	7.9	3.9e-15	-0.86	0.05	0.95	TRUE
36	GTEx	Muscle Skeletal	MTCH2	0.05	0.03	enet	15	0.04	1.5e-04	-6.15	-7.3	4.0e-13	0.84	0.03	0.96	TRUE
101	The Cancer Genome Atlas	Thyroid Carcinoma	C1QTNF4	0.04	0.01	blup	15	0.03	7.9e-04	-7.20	6.4	1.3e-10	-0.89	0.00	0.92	TRUE
65	ROSMAP	Brain Pre-frontal Cortex	C11orf49	0.02	0.02	blup	322	0.02	3.3e-04	4.49	5.8	6.5e-09	-0.25	0.92	0.01	TRUE
97	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	DDB2	0.02	0.03	lasso	1	0.02	1.0e-03	5.68	5.7	1.4e-08	-0.40	0.01	0.91	TRUE
10	GTEx	Brain Cortex	C1QTNF4	0.26	0.04	lasso	8	0.02	1.2e-01	5.04	5.4	7.5e-08	-0.80	0.03	0.48	TRUE
42	GTEx	Prostate	PSMC3	0.21	0.10	lasso	6	0.20	7.9e-06	3.56	-5.2	1.7e-07	0.49	0.14	0.12	TRUE
102	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	ZNF408	0.27	0.01	blup	27	0.09	1.5e-03	6.33	-5.2	2.0e-07	0.03	0.00	0.78	TRUE
22	GTEx	Esophagus Mucosa	ACP2	0.07	0.04	enet	11	0.04	6.2e-04	4.21	-5.2	2.5e-07	0.33	0.77	0.07	TRUE
71	YFS	Blood	PSMC3	0.02	0.01	blup	289	0.01	2.8e-05	-7.27	-7.7	1.3e-14	0.84	0.02	0.98	FALSE
64	ROSMAP	Brain Pre-frontal Cortex	ACP2	0.03	0.00	blup	295	0.02	1.5e-03	-6.56	-7.7	2.0e-14	0.72	0.10	0.76	FALSE
20	GTEx	Colon Transverse	C1QTNF4	0.07	0.02	lasso	6	0.03	2.0e-02	-7.27	7.5	6.6e-14	-0.96	0.02	0.94	FALSE
78	The Cancer Genome Atlas	Esophageal Carcinoma	C1QTNF4	0.39	0.33	blup	15	0.35	6.1e-12	-7.20	7.5	8.6e-14	-0.98	0.00	1.00	FALSE
37	GTEx	Muscle Skeletal	C1QTNF4	0.09	0.14	lasso	3	0.13	9.9e-13	-7.20	7.4	1.2e-13	-0.98	0.01	0.99	FALSE
25	GTEx	Esophagus Muscularis	C1QTNF4	0.10	0.05	enet	23	0.06	1.4e-04	-7.27	7.3	2.6e-13	-0.93	0.02	0.98	FALSE
72	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	C1QTNF4	0.06	0.07	lasso	2	0.06	4.9e-06	-7.05	7.3	3.4e-13	-0.93	0.00	1.00	FALSE
84	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C1QTNF4	0.12	0.14	enet	4	0.16	6.5e-18	-6.96	7.3	3.7e-13	-0.95	0.01	0.99	FALSE
95	The Cancer Genome Atlas	Lung Adenocarcinoma	C1QTNF4	0.03	0.02	blup	15	0.02	1.3e-03	-7.20	7.2	4.1e-13	-0.97	0.00	0.97	FALSE
41	GTEx	Nerve Tibial	C1QTNF4	0.20	0.23	enet	12	0.23	1.7e-16	-7.20	7.2	4.3e-13	-0.96	0.01	0.99	FALSE
100	The Cancer Genome Atlas	Stomach Adenocarcinoma	C1QTNF4	0.06	0.04	lasso	4	0.03	4.3e-03	-7.03	7.2	4.6e-13	-0.92	0.00	0.93	FALSE
4	GTEx	Adipose Subcutaneous	C1QTNF4	0.16	0.22	lasso	4	0.22	2.5e-18	-7.27	7.2	4.7e-13	-0.98	0.01	0.99	FALSE
17	GTEx	Cells Transformed fibroblasts	PSMC3	0.07	0.00	enet	13	0.02	2.3e-02	5.11	-7.2	4.7e-13	0.83	0.04	0.70	FALSE
53	GTEx	Whole Blood	C1QTNF4	0.09	0.05	lasso	3	0.03	1.4e-03	-7.19	7.2	4.7e-13	-0.86	0.02	0.97	FALSE
27	GTEx	Heart Atrial Appendage	C1QTNF4	0.26	0.14	lasso	9	0.17	3.9e-08	-7.20	7.2	4.9e-13	-0.95	0.02	0.98	FALSE
1	CommonMind	Brain Pre-frontal Cortex	FAM180B	0.07	0.08	lasso	3	0.08	9.1e-10	-7.20	-7.2	5.7e-13	0.95	0.03	0.97	FALSE
5	GTEx	Artery Aorta	C1QTNF4	0.09	0.10	lasso	1	0.08	3.2e-05	-7.20	7.2	6.2e-13	-1.00	0.01	0.98	FALSE
23	GTEx	Esophagus Mucosa	C1QTNF4	0.10	0.11	lasso	1	0.10	5.0e-07	-7.20	7.2	6.2e-13	-1.00	0.01	0.99	FALSE
30	GTEx	Heart Left Ventricle	C1QTNF4	0.10	0.11	lasso	1	0.09	1.1e-05	-7.20	7.2	6.2e-13	-1.00	0.01	0.97	FALSE
75	The Cancer Genome Atlas	Colon Adenocarcinoma	C1QTNF4	0.12	0.12	lasso	1	0.12	1.6e-07	-7.20	7.2	6.2e-13	-1.00	0.00	1.00	FALSE
19	GTEx	Cells Transformed fibroblasts	NDUFS3	0.08	0.01	lasso	2	0.01	3.3e-02	-7.27	7.2	7.8e-13	-0.98	0.01	0.94	FALSE
62	ROSMAP	Brain Pre-frontal Cortex	MTCH2	0.35	0.40	enet	9	0.40	4.7e-56	-6.96	-7.2	8.6e-13	0.91	0.03	0.97	FALSE
50	GTEx	Spleen	C1QTNF4	0.31	0.28	enet	29	0.34	1.8e-09	-7.13	7.1	1.3e-12	-0.89	0.02	0.98	FALSE
35	GTEx	Lung	C1QTNF4	0.18	0.15	lasso	6	0.13	3.2e-10	-6.49	7.0	1.8e-12	-0.91	0.04	0.96	FALSE
61	NTR	Blood	MTCH2	0.02	0.04	lasso	1	0.04	1.3e-11	-7.05	7.0	1.8e-12	-0.88	0.02	0.98	FALSE
86	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	C1QTNF4	0.13	0.16	lasso	1	0.16	3.1e-09	-7.04	7.0	1.9e-12	-0.88	0.01	0.99	FALSE
76	The Cancer Genome Atlas	Colon Adenocarcinoma	KBTBD4	0.14	0.01	blup	13	0.02	1.6e-02	5.31	-7.0	2.2e-12	0.90	0.00	0.52	FALSE
92	The Cancer Genome Atlas	Brain Lower Grade Glioma	PSMC3	0.10	0.05	blup	39	0.08	3.7e-09	-6.58	-7.0	2.3e-12	0.79	0.02	0.98	FALSE
55	METSIM	Adipose	C1QTNF4	0.24	0.31	lasso	7	0.31	1.2e-46	-6.96	7.0	2.6e-12	-0.86	0.03	0.97	FALSE
79	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C1QTNF4	0.06	0.08	lasso	3	0.08	7.5e-09	-6.96	7.0	2.8e-12	-0.88	0.01	0.99	FALSE
90	The Cancer Genome Atlas	Brain Lower Grade Glioma	MTCH2	0.11	0.11	lasso	2	0.10	6.4e-12	-6.96	-7.0	2.9e-12	0.87	0.01	0.99	FALSE
93	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	C1QTNF4	0.19	0.19	lasso	3	0.19	3.2e-09	-6.96	7.0	3.0e-12	-0.87	0.01	0.99	FALSE
40	GTEx	Nerve Tibial	SLC39A13	0.07	0.01	enet	14	0.02	7.6e-03	-6.46	-6.8	7.8e-12	0.70	0.12	0.36	FALSE
9	GTEx	Brain Cortex	MTCH2	0.21	0.19	lasso	6	0.16	4.0e-05	-7.13	-6.8	8.0e-12	0.79	0.02	0.96	FALSE
48	GTEx	Skin Sun Exposed Lower leg	C1QTNF4	0.25	0.22	lasso	12	0.23	4.2e-19	-7.20	6.8	9.2e-12	-0.95	0.01	0.99	FALSE
43	GTEx	Skin Not Sun Exposed Suprapubic	LRP4	0.13	0.00	lasso	7	0.02	3.5e-02	4.47	6.8	1.4e-11	-0.60	0.05	0.64	FALSE
28	GTEx	Heart Left Ventricle	MADD	0.14	0.01	enet	17	0.05	7.0e-04	4.53	-6.8	1.5e-11	0.70	0.05	0.89	FALSE
3	GTEx	Adipose Subcutaneous	ACP2	0.08	0.03	enet	18	0.03	3.5e-03	5.80	-6.7	1.6e-11	0.73	0.14	0.63	FALSE
94	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	PSMC3	0.09	0.07	blup	39	0.06	8.7e-04	-6.60	-6.7	1.8e-11	0.85	0.01	0.99	FALSE
67	ROSMAP	Brain Pre-frontal Cortex	PSMC3	0.15	0.08	bslmm	285	0.10	5.1e-13	3.65	-6.7	2.5e-11	0.68	0.69	0.31	FALSE
99	The Cancer Genome Atlas	Prostate Adenocarcinoma	PSMC3	0.02	0.02	blup	39	0.02	5.7e-03	-6.58	-6.6	3.1e-11	0.78	0.01	0.69	FALSE
18	GTEx	Cells Transformed fibroblasts	C1QTNF4	0.13	0.11	enet	19	0.12	5.2e-09	-7.05	6.6	3.2e-11	-0.84	0.02	0.98	FALSE
56	METSIM	Adipose	MYBPC3	0.11	0.10	enet	26	0.11	1.0e-15	-6.58	6.6	3.5e-11	-0.81	0.13	0.87	FALSE
52	GTEx	Testis	MTCH2	0.17	0.16	lasso	3	0.16	1.0e-07	-6.58	-6.6	4.0e-11	0.83	0.08	0.92	FALSE
87	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PSMC3	0.07	0.07	enet	7	0.06	1.4e-04	-6.46	-6.6	5.4e-11	0.82	0.01	0.98	FALSE
13	GTEx	Breast Mammary Tissue	C1QTNF4	0.10	0.06	lasso	2	0.03	8.5e-03	-6.58	6.5	6.2e-11	-0.82	0.05	0.86	FALSE
54	METSIM	Adipose	ACP2	0.05	0.04	blup	302	0.06	1.7e-09	-6.58	-6.5	6.7e-11	0.67	0.10	0.90	FALSE
91	The Cancer Genome Atlas	Brain Lower Grade Glioma	MYBPC3	0.03	0.01	blup	43	0.02	3.2e-03	-6.60	6.5	8.3e-11	-0.72	0.00	0.90	FALSE
7	GTEx	Brain Cerebellar Hemisphere	ACP2	0.29	0.05	enet	16	0.12	5.9e-04	5.64	-6.5	9.1e-11	0.44	0.08	0.14	FALSE
46	GTEx	Skin Sun Exposed Lower leg	ACP2	0.16	0.14	enet	15	0.15	1.8e-12	5.88	-6.5	1.0e-10	0.49	0.98	0.02	FALSE
15	GTEx	Breast Mammary Tissue (Female)	MADD	0.13	0.04	lasso	3	0.05	1.3e-02	-6.50	-6.4	1.6e-10	0.81	0.04	0.48	FALSE
16	GTEx	Cells Transformed fibroblasts	FNBP4	0.11	0.05	lasso	8	0.08	1.6e-06	5.20	-6.3	2.1e-10	0.88	0.10	0.90	FALSE
8	GTEx	Brain Cerebellum	MADD	0.21	0.00	enet	13	0.11	3.3e-04	4.23	-6.3	2.8e-10	0.63	0.10	0.55	FALSE
45	GTEx	Skin Not Sun Exposed Suprapubic	C1QTNF4	0.32	0.18	enet	33	0.20	5.2e-11	-7.20	6.3	3.0e-10	-0.90	0.01	0.99	FALSE
98	The Cancer Genome Atlas	Prostate Adenocarcinoma	NUP160	0.03	0.02	enet	7	0.02	6.3e-03	-6.15	-6.3	3.1e-10	0.83	0.01	0.90	FALSE
31	GTEx	Heart Left Ventricle	ARHGAP1	0.06	0.03	lasso	2	0.02	2.1e-02	6.44	-6.2	6.4e-10	0.21	0.02	0.90	FALSE
81	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MYBPC3	0.05	0.03	blup	43	0.04	6.0e-05	-5.46	6.2	7.2e-10	-0.71	0.01	0.98	FALSE
29	GTEx	Heart Left Ventricle	ACP2	0.11	0.06	enet	18	0.10	9.2e-06	4.53	-6.1	9.9e-10	0.35	0.79	0.03	FALSE
33	GTEx	Liver	C1QTNF4	0.25	0.14	enet	16	0.20	2.3e-06	-7.20	6.1	1.1e-09	-0.84	0.02	0.96	FALSE
77	The Cancer Genome Atlas	Colon Adenocarcinoma	NUP160	0.05	0.05	blup	44	0.05	7.7e-04	5.22	-6.1	1.2e-09	0.82	0.08	0.23	FALSE
57	METSIM	Adipose	PSMC3	0.06	0.03	enet	28	0.04	2.3e-06	-4.70	-6.0	1.7e-09	0.79	0.04	0.95	FALSE
51	GTEx	Testis	NR1H3	0.10	0.10	lasso	6	0.08	2.9e-04	5.93	-6.0	1.8e-09	0.41	0.61	0.03	FALSE
82	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	NUP160	0.08	0.03	blup	42	0.04	6.7e-05	-7.05	-6.0	2.3e-09	0.71	0.01	0.97	FALSE
6	GTEx	Brain Cerebellar Hemisphere	MADD	0.44	0.14	lasso	7	0.21	4.0e-06	5.80	-5.9	2.9e-09	0.50	0.24	0.40	FALSE
70	YFS	Blood	NUP160	0.02	0.01	blup	290	0.01	1.7e-04	-7.18	-5.8	4.8e-09	0.65	0.02	0.96	FALSE
89	The Cancer Genome Atlas	Brain Lower Grade Glioma	MADD	0.08	0.01	lasso	5	0.05	3.1e-06	-6.56	-5.8	4.9e-09	0.62	0.00	0.95	FALSE
85	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PSMC3	0.05	0.04	lasso	3	0.05	3.8e-06	-4.70	-5.8	5.5e-09	0.73	0.02	0.98	FALSE
47	GTEx	Skin Sun Exposed Lower leg	PSMC3	0.20	0.05	lasso	7	0.10	1.2e-08	5.11	-5.8	6.1e-09	0.68	0.48	0.50	FALSE
83	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ACP2	0.03	0.03	blup	44	0.04	3.5e-05	5.93	-5.8	6.5e-09	0.38	0.01	0.99	FALSE
34	GTEx	Lung	ACP2	0.04	0.03	lasso	2	0.04	4.3e-04	5.66	-5.8	7.1e-09	0.39	0.55	0.02	FALSE
60	NTR	Blood	DDB2	0.01	0.00	lasso	7	0.01	2.2e-03	6.04	-5.8	9.2e-09	0.28	0.31	0.05	FALSE
24	GTEx	Esophagus Muscularis	MTCH2	0.09	0.04	lasso	6	0.02	1.8e-02	-7.05	-5.7	1.0e-08	0.78	0.03	0.95	FALSE
58	METSIM	Adipose	RAPSN	0.11	0.01	enet	21	0.06	7.9e-09	2.13	5.7	1.2e-08	-0.42	0.31	0.69	FALSE
63	ROSMAP	Brain Pre-frontal Cortex	LRP4	0.04	0.06	blup	286	0.05	3.5e-07	5.64	5.7	1.2e-08	-0.20	0.48	0.52	FALSE
49	GTEx	Spleen	ACP2	0.19	-0.01	lasso	5	0.04	4.1e-02	6.04	-5.6	1.6e-08	0.27	0.11	0.12	FALSE
32	GTEx	Liver	PSMC3	0.15	0.09	lasso	4	0.07	5.9e-03	-5.10	-5.6	1.8e-08	0.59	0.04	0.57	FALSE
11	GTEx	Brain Hypothalamus	NR1H3	0.25	0.18	lasso	5	0.10	2.7e-03	5.78	5.6	2.1e-08	-0.41	0.15	0.09	FALSE
12	GTEx	Brain Putamen basal ganglia	CKAP5	0.25	0.07	lasso	3	0.14	4.4e-04	4.78	5.6	2.4e-08	-0.44	0.06	0.08	FALSE
14	GTEx	Breast Mammary Tissue	CKAP5	0.09	0.05	enet	16	0.03	1.3e-02	4.51	5.6	2.8e-08	-0.21	0.47	0.29	FALSE
59	NTR	Blood	ACP2	0.01	0.00	enet	7	0.01	2.5e-03	4.21	-5.5	3.4e-08	0.44	0.44	0.09	FALSE
2	CommonMind	Brain Pre-frontal Cortex	MTCH2	0.03	0.00	bslmm	299	0.00	1.1e-01	0.88	-5.5	3.6e-08	0.68	0.04	0.74	FALSE
26	GTEx	Heart Atrial Appendage	ACP2	0.10	0.12	enet	7	0.10	2.7e-05	4.20	-5.5	4.5e-08	0.49	0.32	0.07	FALSE
73	The Cancer Genome Atlas	Breast Invasive Carcinoma	C1QTNF4	0.02	0.01	lasso	5	0.02	2.1e-04	2.73	5.5	4.7e-08	-0.74	0.02	0.73	FALSE
69	YFS	Blood	NR1H3	0.34	0.15	enet	66	0.24	3.1e-76	5.68	-5.4	5.2e-08	0.56	0.99	0.01	FALSE
44	GTEx	Skin Not Sun Exposed Suprapubic	DDB2	0.07	0.02	enet	13	0.04	3.5e-03	5.66	5.3	1.0e-07	-0.16	0.15	0.04	FALSE
38	GTEx	Nerve Tibial	LRP4	0.28	0.24	enet	24	0.30	3.5e-21	-3.64	5.3	1.2e-07	-0.34	1.00	0.00	FALSE
96	The Cancer Genome Atlas	Lung Adenocarcinoma	MYBPC3	0.04	0.02	enet	10	0.04	2.9e-05	-6.49	5.3	1.3e-07	-0.68	0.01	0.98	FALSE
88	The Cancer Genome Atlas	Brain Lower Grade Glioma	ACP2	0.09	0.04	enet	12	0.06	5.0e-07	5.80	-5.3	1.4e-07	0.56	0.01	0.99	FALSE
74	The Cancer Genome Atlas	Breast Invasive Carcinoma	MYBPC3	0.02	0.01	blup	43	0.01	3.4e-03	-6.49	5.2	1.5e-07	-0.74	0.01	0.97	FALSE
66	ROSMAP	Brain Pre-frontal Cortex	CELF1	0.03	0.01	bslmm	289	0.01	2.9e-02	4.32	5.2	1.7e-07	-0.50	0.17	0.11	FALSE
80	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	FNBP4	0.10	0.03	blup	45	0.05	7.7e-06	-7.18	-5.2	2.2e-07	0.51	0.00	0.99	FALSE
39	GTEx	Nerve Tibial	PTPRJ	0.05	0.03	enet	13	0.03	2.7e-03	3.53	5.2	2.6e-07	-0.50	0.15	0.27	FALSE
21	GTEx	Esophagus Gastroesophageal Junction	CKAP5	0.11	0.04	lasso	3	0.03	2.1e-02	4.43	5.1	2.9e-07	-0.29	0.24	0.20	FALSE