TWAS hub - NUP62

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Testis	0.2060	0.0740	0.00260	0.095	NA	0.023	NA	0.046	5.5e-05	NA	3.4e-02	NA	4.2e-03
2	TCGA	Brain Lower Grade Glioma	0.0384	0.0195	0.00350	0.019	0.025	0.023	NA	0.025	2.8e-03	6.2e-04	1.0e-03	NA	6.9e-04
3	TCGA	Lung Adenocarcinoma	0.0344	0.0185	0.00110	0.032	0.025	0.016	NA	0.029	1.0e-04	5.1e-04	5.1e-03	NA	2.1e-04
4	TCGA	Prostate Adenocarcinoma	0.0500	0.0242	0.00018	0.046	0.047	0.041	NA	0.040	1.2e-05	9.5e-06	3.9e-05	NA	4.5e-05
5	TCGA	Thyroid Carcinoma	0.0620	0.0270	0.00014	0.057	0.042	0.050	NA	0.054	2.8e-06	5.2e-05	1.2e-05	NA	5.7e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Alzheimer’s Disease (including proxy)	8.5	12.3	13.9	3.2	3.6	3.4	3.7	3.5
Time employed in main current job	6.7	7.7	8.7	2.6	3.0	2.8	2.8	2.7
Relative age of first facial hair	5.8	12.0	13.3	3.5	3.2	3.3	3.6	3.6
Medication: Ibuprofen	5.8	7.0	11.3	-3.4	-2.0	-2.7	-1.9	-2.9
Myopia	5.6	8.2	10.5	3.0	3.2	2.8	1.8	3.2
Migraine (self-reported)	5.4	6.7	10.4	-2.4	-2.2	-3.2	-2.5	-2.5
Impedance of whole body	5.2	26.6	33.9	5.6	3.8	5.4	5.8	5.0
Alzheimer’s Disease (in father)	5.0	5.5	6.7	2.4	2.5	2.3	1.9	2.6
Breast cancer (self-reported)	4.7	5.7	7.8	-2.7	-2.3	-2.2	-1.8	-2.8
Impedance of arm (left)	4.6	21.2	28.5	4.9	3.5	4.7	5.3	4.4
Medication: Ibuprofen (e.g. Nurofen)	4.2	5.3	8.8	-3.0	-1.5	-2.6	-1.5	-2.5
Impedance of leg (right)	3.9	19.1	24.4	4.9	3.2	4.7	4.4	4.4
Impedance of leg (left)	3.9	18.8	23.4	4.8	3.2	4.6	4.6	4.2
Impedance of arm (right)	3.8	17.8	24.3	4.6	3.1	4.2	4.9	4.0
Alzheimer’s Disease (in mother)	3.6	4.2	6.2	1.9	1.9	2.0	2.5	1.9
Medication: Seretide 50 evohaler	3.6	4.2	5.7	2.0	2.3	2.4	1.2	2.1
Heart disease (mother)	3.6	4.3	6.6	-1.8	-2.1	-2.2	-2.6	-1.6
Headache pain in last month	3.5	5.9	8.2	-2.3	-2.9	-2.3	-2.8	-1.8
Eye problems/disorders: None of the above	3.5	4.1	5.6	1.8	2.2	2.1	1.5	2.4
Osteoporosis (self-reported)	3.5	4.4	5.6	1.9	2.4	2.3	2.0	1.8
Relative age voice broke	3.4	5.2	5.8	2.1	2.4	2.4	2.1	2.4
Medication: Atenolol	3.4	4.3	6.1	-2.5	-1.7	-2.2	-1.7	-2.2
Serious illness, injury or assault of a close relative in last 2 years	3.4	4.0	4.7	1.8	2.2	2.0	2.0	1.9
Average weekly champagne plus white wine intake	3.4	4.6	6.6	2.3	1.8	2.6	1.9	2.1
Angina	3.3	4.3	5.5	-2.0	-2.2	-2.3	-1.4	-2.2
Angina (self-reported)	3.3	4.4	5.7	-2.0	-2.3	-2.4	-1.5	-2.2
Happiness	3.2	3.8	5.8	-2.4	-1.6	-2.1	-1.2	-2.2
Arm predicted mass (left)	3.1	15.8	23.3	-4.2	-2.8	-4.1	-4.8	-3.6
Body Mass Index (BMI) (2010)	2.9	4.0	5.1	-2.2	-1.8	-2.3	-1.6	-2.0
Major Depression (MDD)	2.8	3.4	4.3	-1.9	-2.1	-1.8	-2.0	-1.5
Trunk fat-free mass	2.8	16.2	25.3	-4.3	-2.7	-4.0	-5.0	-3.8
Pulse rate	2.8	4.8	6.4	-2.5	-2.0	-2.1	-2.0	-2.3
Trunk predicted mass	2.8	16.2	25.3	-4.2	-2.8	-4.0	-5.0	-3.8
Arm fat-free mass (left)	2.7	13.6	20.6	-3.9	-2.6	-3.8	-4.5	-3.3
Leg pain on walking	2.6	3.3	4.5	-2.1	-1.5	-2.0	-1.5	-1.8
Primary Biliary Cirrhosis	2.5	3.5	5.1	-1.4	-2.2	-2.2	-1.8	-1.6
Qualifications: O levels/GCSEs or equivalent	2.5	4.0	5.2	-2.2	-1.5	-2.3	-1.6	-2.2
Commuting to job workplace: Car/motor vehicle	2.5	2.9	4.9	-1.8	-1.5	-2.2	-1.1	-1.7
Whole body fat-free mass	2.5	14.0	20.7	-4.0	-2.6	-3.8	-4.5	-3.5
Whole body water mass	2.5	14.2	20.9	-4.1	-2.6	-3.8	-4.6	-3.5
Pain experienced in last month	2.5	4.1	7.3	2.1	2.7	1.9	1.6	1.7
Basal metabolic rate	2.4	13.2	19.5	-3.9	-2.6	-3.7	-4.4	-3.3
Number of operations (self-reported)	2.4	3.5	6.1	1.6	1.4	1.8	2.5	2.0
Shortness of breath walking on level ground	2.3	2.8	3.3	-1.8	-1.4	-1.7	-1.8	-1.6
Average weekly red wine intake	2.3	3.4	4.4	1.8	1.7	2.0	1.7	2.1
Neuroticism (2016)	2.2	3.2	3.5	1.8	1.8	1.7	1.9	1.8
Ever used hormone-replacement therapy (HRT)	2.2	2.7	3.8	1.2	1.8	1.7	2.0	1.5
Tinnitus: Yes, but not now, but have in the past	2.2	2.4	2.8	-1.4	-1.7	-1.6	-1.6	-1.4
Serious illness, injury or assault to yourself	2.2	2.7	3.3	-1.8	-1.7	-1.8	-1.3	-1.6
Mouth/teeth dental problems: Bleeding gums	2.2	2.9	3.6	1.6	1.7	1.4	1.9	1.9
Arm fat-free mass (right)	2.2	11.1	16.6	-3.6	-2.4	-3.3	-4.1	-3.0
Medication for pain relief, constipation, heartburn	2.1	3.5	5.2	2.3	1.9	2.0	1.0	2.0
Arm predicted mass (right)	2.1	10.6	16.7	-3.5	-2.3	-3.2	-4.1	-2.9
Number of full sisters	2.1	2.5	3.8	1.4	1.9	1.5	1.3	1.7
Leg fat-free mass (right)	2.1	11.0	14.1	-3.8	-2.3	-3.4	-3.7	-3.2
Fractured/broken bones in last 5 years	2.1	2.8	4.0	1.8	1.6	2.0	0.9	1.7
Length of working week for main job	2.0	2.2	3.1	1.8	1.1	1.2	1.7	1.6
Pulse wave peak to peak time	2.0	2.4	3.3	1.8	1.2	1.5	1.5	1.6
Leg predicted mass (right)	2.0	10.7	13.7	-3.7	-2.3	-3.4	-3.7	-3.1
Heart disease (siblings)	2.0	2.4	3.2	1.4	1.6	1.4	1.8	1.6
Blood Red Count	1.9	18.5	21.7	4.5	4.4	4.3	3.6	4.7
Birth weight of first child	1.9	3.4	4.8	-1.5	-1.8	-2.2	-1.9	-1.8
Rheumatoid Arthritis	1.8	2.4	4.0	1.5	1.7	2.0	0.5	1.6
Leg fat-free mass (left)	1.8	9.7	13.4	-3.4	-2.2	-3.2	-3.7	-2.8
Body mass index (BMI)	1.8	7.8	9.8	-2.9	-2.2	-3.1	-3.1	-2.4
Leg predicted mass (left)	1.8	9.3	13.2	-3.4	-2.1	-3.1	-3.6	-2.8
Pulse wave Arterial Stiffness index	1.8	2.1	3.1	-1.8	-1.1	-1.4	-1.4	-1.6
Blood clot in the leg (DVT)	1.8	2.3	4.2	-1.5	-2.1	-1.3	-1.3	-1.4
Medication: Paracetamol	1.8	2.8	4.1	-2.0	-2.0	-1.7	-1.0	-1.5
Had menopause	1.7	2.2	2.4	1.4	1.3	1.6	1.5	1.5
Pulse rate, automated reading	1.7	5.4	7.2	-2.7	-2.1	-2.3	-1.9	-2.6
Suffer from ‘nerves’	1.7	2.7	3.5	1.6	1.9	1.4	1.7	1.5
Medication: Omeprazole (e.g. Zanprol)	1.7	2.0	2.8	1.3	1.4	1.3	1.7	1.4
Frequency of depressed mood in last 2 weeks	1.6	2.2	3.5	-1.6	-1.9	-1.2	-1.4	-1.3
Systolic blood pressure, automated reading	1.6	4.6	6.8	-2.2	-1.8	-2.6	-1.9	-2.1
Heel bone mineral density (BMD) T-score, automated (left)	1.6	3.7	5.2	-1.6	-2.1	-2.3	-1.4	-2.0
Heel bone mineral density (BMD) T-score, automated (right)	1.6	3.6	5.4	-1.6	-1.9	-2.3	-1.6	-2.0
Weight	1.6	8.0	12.0	-3.0	-2.0	-3.0	-3.5	-2.4
Alcohol intake frequency.	1.6	3.6	7.0	-2.1	-1.4	-2.6	-1.2	-1.8
BMI	1.5	8.6	11.4	-3.1	-2.1	-3.3	-3.4	-2.5
Hearing difficulty/problems: Yes	1.5	2.2	2.8	-1.6	-1.7	-1.6	-0.9	-1.6
Birth weight	1.5	3.2	5.1	-1.8	-1.4	-1.6	-2.3	-1.7
Supplements: Vitamin C	1.5	1.8	2.5	1.5	1.3	0.9	1.6	1.3
Eye problems/disorders: Cataract	1.5	1.8	2.5	-1.2	-0.8	-1.5	-1.6	-1.4
Vitamin and mineral supplements	1.4	1.9	2.3	-1.5	-1.5	-1.3	-1.0	-1.4
Number of incorrect matches in round	1.4	2.3	4.0	1.1	1.7	2.0	1.6	1.0
Falls in the last year	1.4	2.0	2.4	1.5	1.4	1.5	1.2	1.4
Pulse wave reflection index	1.4	1.7	2.8	-1.0	-1.1	-1.7	-1.4	-1.3
Ever had prostate specific antigen (PSA) test	1.4	1.6	3.3	-1.8	-0.7	-1.3	-0.9	-1.3
Pack years of smoking	1.4	2.1	2.9	-1.3	-1.6	-1.7	-1.0	-1.5
Allergy or Eczema	1.3	3.5	4.6	1.7	1.4	2.1	2.0	2.1
Hip circumference	1.3	5.5	8.6	-2.4	-2.1	-2.4	-2.9	-1.8
Medication: Cholesterol lowering	1.3	2.0	3.4	1.8	1.1	1.5	1.1	1.4
Depression (self-reported)	1.3	1.6	3.6	-0.8	-1.9	-1.5	-0.6	-1.1
Commuting to job workplace: Cycle	1.3	1.6	2.7	1.1	0.7	1.4	1.6	1.2
Bipolar Disorder (2018)	1.2	1.9	3.4	-1.3	-1.9	-1.3	-1.2	-1.1
Age at First Birth	1.2	1.8	2.8	1.7	0.7	1.5	0.8	1.7
Pack years adult smoking proportion	1.2	1.9	2.8	-1.2	-1.6	-1.7	-1.0	-1.3
Townsend deprivation index at recruitment	1.2	1.7	2.9	1.4	1.4	0.7	1.2	1.7
Frequency of tiredness / lethargy in last 2 weeks	1.2	2.0	3.4	-1.5	-1.6	-1.9	-0.4	-1.2
Arm fat mass (right)	1.2	4.8	6.9	-2.2	-1.7	-2.5	-2.6	-1.8
Medication: Paracetamol	1.2	2.0	3.0	-1.7	-1.6	-1.4	-0.9	-1.2
Deep venous thrombosis (DVT) (self-reported)	1.2	1.6	3.3	-1.2	-1.8	-1.0	-1.1	-1.1
Fasting Glucose	1.1	1.4	4.0	0.8	2.0	0.7	0.9	1.0
Triglycerides	1.1	1.8	2.2	-1.4	-1.5	-1.0	-1.3	-1.4
Number of treatments/medications taken	1.1	2.0	3.3	-1.4	-1.8	-1.3	-1.1	-1.4
Prospective memory result	1.1	1.4	2.0	-1.2	-0.4	-1.2	-1.4	-1.2
Hair/balding pattern: Pattern 4	1.1	2.6	4.7	1.5	2.2	1.9	0.9	1.3
Arm fat mass (left)	1.1	4.6	6.9	-2.1	-1.8	-2.3	-2.6	-1.7
Medication: Atorvastatin	1.1	1.3	1.9	1.4	0.9	0.9	1.0	1.4
Alcohol drinker status: Previous	1.1	1.3	2.2	-1.5	-0.8	-1.2	-0.2	-1.4
LDL Cholesterol	1.0	1.6	2.3	-1.5	-1.0	-1.2	-1.0	-1.5
Hair/balding pattern: Pattern 3	1.0	1.5	2.1	-1.3	-1.4	-1.2	-0.4	-1.5
Noisy workplace	1.0	1.3	2.6	-1.1	-1.2	-1.6	0.1	-1.0
Qualifications: A levels/AS levels or equivalent	1.0	2.1	2.6	-1.6	-1.3	-1.6	-1.4	-1.3
Medication: Lansoprazole	1.0	1.2	2.8	1.0	0.2	1.2	1.7	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.0	3.7	-1.4	-1.1	-1.9	-0.9	-1.5
Mother’s age at death	1.0	1.2	2.1	1.2	0.8	1.4	1.0	1.0
Sitting height	0.9	6.6	9.0	-2.8	-1.7	-2.7	-3.0	-2.4
Medication for cholesterol, blood pressure or diabetes	0.9	1.5	2.7	-1.6	-0.7	-1.2	-0.8	-1.5
Gout (self-reported)	0.9	1.3	1.4	-1.1	-1.1	-1.2	-1.1	-1.1
Emphysema/chronic bronchitis	0.9	1.0	1.5	1.1	0.4	1.2	1.0	1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.9	3.4	-1.2	-1.6	-0.9	-1.8	-1.3
Handedness (chirality/laterality): Left-handed	0.9	1.1	1.8	1.1	1.3	0.3	0.6	1.3
Back pain experienced in last month	0.9	1.3	1.9	-1.4	-0.8	-1.2	-1.2	-0.9
Ever smoked	0.9	1.5	2.9	-1.4	-1.1	-0.5	-1.7	-1.2
Diastolic blood pressure, automated reading	0.9	2.7	3.8	-2.0	-1.0	-1.8	-1.9	-1.5
Crohns Disease (2012)	0.8	1.2	1.7	1.0	0.8	1.3	1.3	1.1
HDL Cholesterol	0.8	1.3	1.7	1.2	1.3	0.9	1.1	1.1
Waist Hip Ratio (WHR)	0.8	3.7	4.8	1.7	2.2	1.7	1.9	2.0
Sensitivity / hurt feelings	0.8	1.4	2.6	1.2	0.9	1.0	1.0	1.6
Hand grip strength (right)	0.8	2.2	5.3	-1.3	-1.1	-1.3	-2.3	-1.2
Financial difficulties in last 2 years	0.8	1.1	2.3	-0.9	-1.5	-1.3	-0.2	-0.8
Illnesses of mother	0.8	1.0	1.4	1.0	1.2	0.9	1.2	0.8
Leg fat mass (right)	0.8	2.9	5.2	-1.7	-1.4	-1.8	-2.3	-1.2
Medication: Gliclazide	0.8	0.9	1.5	-0.9	-1.0	-0.9	0.5	-1.2
Systolic Blood Pressure	0.7	3.6	5.5	-1.8	-1.7	-2.4	-1.7	-1.9
Chronotype (morning person)	0.7	1.7	3.0	-1.4	-1.7	-1.0	-0.6	-1.4
Supplements: Zinc	0.7	0.8	1.2	-1.1	-0.9	-0.9	-0.7	-0.8
Severe depression (siblings)	0.7	0.8	1.7	0.9	0.7	0.6	1.3	0.7
Hayfever, allergic rhinitis or eczema	0.7	1.5	2.7	1.1	0.9	1.2	1.6	1.2
High blood pressure (mother)	0.7	1.0	1.3	-1.1	-1.1	-0.9	-1.1	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.2	3.3	-1.6	-0.7	-1.8	-1.5	-1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	1.8	-1.3	-1.0	-1.0	-0.4	-1.3
Medication: Ventolin 100micrograms inhaler	0.7	0.9	1.4	-1.0	-1.2	-0.4	-1.1	-1.1
Health satisfaction	0.7	0.9	1.7	-1.3	-0.6	-1.0	0.1	-1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	1.7	0.6	0.8	1.0	1.3	0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	1.9	0.6	1.4	0.6	0.8	0.7
High cholesterol (Self-reported)	0.7	1.2	3.1	1.8	0.8	0.7	0.5	1.3
Leg fat mass (left)	0.7	2.7	4.6	-1.6	-1.3	-1.8	-2.1	-1.2
Bipolar Disorder or Schizophrenia	0.6	1.4	2.0	-1.2	-1.4	-0.9	-1.4	-0.8
Lung FEV1/FVC ratio	0.6	2.8	4.8	-1.8	-1.1	-2.2	-0.8	-2.0
Current tobacco smoking	0.6	1.0	2.1	-1.1	-1.0	-0.5	-0.7	-1.4
Taking other prescription medications	0.6	0.9	2.2	-1.0	-1.5	-0.8	-0.4	-0.7
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.4	-1.2	-0.2	-0.8	-0.7	-0.9
Medication: Levothyroxine sodium	0.6	1.0	1.8	-0.9	-1.3	-1.2	-0.6	-0.8
Waist circumference	0.6	2.2	3.9	-1.6	-1.0	-1.6	-2.0	-0.9
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	2.2	-0.7	-1.5	-0.9	-0.5	-0.5
Father’s age at death	0.6	0.8	1.4	0.9	0.7	1.2	0.9	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	1.4	-1.2	-0.8	-1.1	-0.3	-0.8
Mean time to correctly identify matches	0.6	1.1	1.5	1.2	0.7	1.0	1.2	1.0
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.6	0.5	0.7	0.8	1.3	0.6
Long-standing illness, disability or infirmity	0.6	1.0	1.5	-1.2	-0.9	-1.2	-0.5	-1.0
Ever had bowel cancer screening	0.6	0.7	1.3	0.8	0.5	1.1	0.9	0.5
Number of self-reported non-cancer illnesses	0.6	1.1	2.1	-0.8	-1.3	-1.5	-0.3	-1.0
Ever taken oral contraceptive pill	0.6	0.6	0.8	0.7	0.8	0.9	0.7	0.9
Pain type(s) experienced in last month: Hip pain	0.6	0.7	1.4	-0.9	-0.6	-1.2	-0.4	-0.9
Supplements: Calcium	0.6	0.6	1.0	0.5	1.0	0.8	0.5	1.0
Depression (Nagel 2018)	0.5	0.7	1.6	-0.7	-1.3	-0.7	-0.9	-0.4
Ovarian Cancer	0.5	0.7	1.4	0.7	1.2	0.7	0.7	0.7
Prostate Cancer	0.5	0.7	1.6	0.7	0.8	0.7	0.4	1.2
Qualifications: CSEs or equivalent	0.5	0.6	1.1	0.9	1.0	0.2	1.0	0.6
Chronic bronchitis/emphysema (father)	0.5	0.6	1.0	-0.7	-0.7	-1.0	-0.6	-0.9
Hearing difficulty/problems with background noise	0.5	0.8	1.6	-1.0	-1.3	-0.5	-0.4	-1.1
Mouth/teeth dental problems	0.5	0.7	2.2	-0.7	-0.2	-0.3	-1.5	-0.9
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.9	-0.3	-1.4	-0.9	0.3	-0.1
Comparative body size at age 10	0.5	1.3	1.9	-1.4	-0.8	-0.6	-1.3	-1.3
Whole body fat mass	0.5	2.2	3.7	-1.4	-1.3	-1.6	-1.9	-0.9
Smoking status: Current	0.5	0.7	1.5	-0.9	-0.9	-0.4	-0.6	-1.2
Wears glasses or contact lenses	0.5	0.5	1.4	0.6	0.6	1.2	0.3	0.7
Hearing aid user	0.5	0.5	1.0	-0.5	-0.5	-1.0	-1.0	-0.5
Average weekly beer plus cider intake	0.5	0.7	1.1	-0.7	-0.6	-1.0	-1.1	-0.7
Neuroticism (Nagel 2018)	0.4	0.9	2.0	0.7	0.7	0.9	1.4	0.9
Tanning	0.4	4.8	8.9	3.0	1.2	2.1	1.4	2.7
Ever had hysterectomy (womb removed)	0.4	0.5	0.7	0.8	0.5	0.5	0.8	0.7
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	1.8	-0.1	-0.0	0.7	1.3	-0.3
Medication: Metformin	0.4	0.6	1.2	0.8	-0.2	0.7	1.1	0.7
Diabetes (mother)	0.4	0.5	1.4	-0.5	-0.6	-0.3	-1.2	-0.5
Trunk fat mass	0.4	1.8	2.6	-1.3	-1.2	-1.5	-1.6	-0.9
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.3	0.5	-0.7	0.5	1.2	0.8
Allergy	0.4	0.9	1.8	-0.8	0.1	-0.9	-1.4	-1.0
Lung cancer (father)	0.4	0.4	0.7	0.8	0.7	0.5	0.3	0.8
Breastfed as a baby	0.4	0.4	1.3	-0.6	-0.6	0.1	-0.5	-1.1
Medication: Omeprazole	0.4	0.5	0.7	0.5	0.8	0.8	0.7	0.5
Overall health rating	0.4	0.9	1.5	-1.0	-1.1	-1.2	0.4	-0.9
Illnesses of father: Heart disease	0.4	0.5	1.1	-0.8	-0.5	-1.0	-0.6	-0.5
Illnesses of siblings: Diabetes	0.4	0.5	1.7	0.5	0.3	0.3	1.3	0.7
Qualifications: nursing, teaching	0.4	0.6	1.0	-1.0	-0.1	-0.9	-0.8	-0.7
Osteoarthritis (self-reported)	0.4	0.5	1.2	-0.9	-0.3	-1.1	-0.4	-0.6
Illnesses of father: High blood pressure	0.4	0.4	1.1	-0.6	-0.5	-1.1	-0.6	-0.3
Alcohol drinker status: Never	0.4	0.5	1.0	-0.3	-0.4	-1.0	-0.9	-0.5
Worry (Nagel 2018)	0.3	0.7	1.2	0.9	0.4	1.1	0.9	0.6
Heel T-Score	0.3	2.5	3.2	-1.8	-1.5	-1.7	-1.2	-1.6
Lung FVC	0.3	1.3	2.2	-1.2	-0.9	-1.4	-0.6	-1.5
Hand grip strength (left)	0.3	0.9	2.6	-0.9	-0.2	-0.6	-1.6	-0.7
Medication for hormone replacement therapy	0.3	0.4	0.7	0.6	0.6	0.5	0.8	0.5
Multivitamins +/- minerals	0.3	0.4	1.2	0.3	1.1	0.5	0.0	0.4
Past tobacco smoking	0.3	0.5	1.3	0.7	0.4	0.5	1.1	0.6
Pain all over the body in last month	0.3	0.3	0.5	-0.3	-0.6	-0.7	0.7	-0.3
Diabetes (self-reported)	0.3	0.4	0.6	0.7	0.3	0.7	0.8	0.7
Arm fat percentage (right)	0.3	1.4	2.2	-1.0	-1.0	-1.5	-1.4	-0.8
Alcohol intake versus 10 years previously	0.3	0.5	1.1	1.1	-0.0	0.4	0.9	0.6
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	1.7	-1.0	-0.2	-1.3	-1.2	-0.9
Medication: Amlodipine	0.3	0.4	1.2	0.5	0.7	-0.1	1.1	-0.0
Forced vital capacity (FVC), Best measure	0.3	1.1	1.8	-1.3	-0.4	-1.3	-0.9	-1.2
Number of children fathered	0.3	0.3	0.5	0.6	0.3	0.1	0.7	0.7
Mouth/teeth dental problems: Loose teeth	0.3	0.3	0.8	0.5	-0.5	0.4	0.9	0.4
Age at last live birth	0.3	0.5	1.0	0.9	0.1	0.8	-0.1	1.0
Arm fat percentage (left)	0.3	1.0	1.5	-0.9	-1.0	-1.2	-1.2	-0.6
Commuting to job workplace: Walk	0.3	0.3	0.7	0.7	0.4	0.9	0.2	0.4
Illnesses of father: None of the above (group 1)	0.3	0.4	0.9	0.4	0.7	1.0	0.6	0.3
Depressed Affect (Nagel 2018)	0.2	0.5	1.3	0.2	0.7	0.6	1.2	0.4
Ulcerative Colitis (UC)	0.2	0.3	0.5	-0.4	-0.7	-0.7	-0.2	-0.5
Verbal and Numeric Reasoning (VNR)	0.2	0.6	1.5	-0.5	-0.9	-0.4	-1.2	-0.4
Breast Cancer	0.2	0.4	1.4	0.4	0.5	0.5	1.2	0.3
Lupus	0.2	0.3	0.6	-0.6	-0.2	-0.7	0.1	-0.8
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.6	0.0	-0.8	-0.1	-0.5	-0.2
Height	0.2	4.0	6.6	-2.1	-1.6	-1.8	-2.6	-1.9
Type 2 Diabetes (T2D) (2018)	0.2	0.3	0.5	-0.5	-0.7	-0.7	0.4	-0.5
Neuroticism	0.2	0.5	1.6	0.5	0.3	0.5	1.3	0.5
Fed-up feelings	0.2	0.4	1.8	-0.1	0.7	-0.1	1.3	0.1
High blood pressure	0.2	0.6	1.1	-0.7	-0.9	-1.1	-0.2	-0.8
Stomach or abdominal pain in last month	0.2	0.2	0.3	-0.1	0.6	0.6	0.4	0.3
Hair/balding pattern: Pattern 2	0.2	0.3	0.8	-0.2	-0.9	-0.5	-0.1	-0.4
Forced vital capacity (FVC)	0.2	0.6	1.1	-0.8	-0.1	-0.9	-1.0	-0.7
Number of live births	0.2	0.2	0.8	0.4	0.1	-0.1	0.9	0.4
Mouth/teeth dental problems: Dentures	0.2	0.3	1.2	-0.2	-0.4	-0.4	1.1	-0.4
Peak expiratory flow (PEF)	0.2	0.4	0.9	-0.7	0.3	-0.8	-0.9	-0.3
Loud music exposure frequency	0.2	0.2	0.4	-0.2	-0.3	-0.5	-0.7	-0.2
Exposure to tobacco smoke outside home	0.2	0.3	0.6	0.8	0.1	0.6	0.2	0.7
Number of full brothers	0.2	0.2	0.8	-0.3	0.0	-0.9	-0.2	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.5	-0.5	0.1	-0.3	0.6	-0.7
Medication: Blood pressure	0.2	0.3	0.5	0.7	0.1	0.6	0.5	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	0.4	0.7	0.4	0.6	0.4	0.5
Chest pain or discomfort	0.2	0.4	0.9	0.6	0.1	0.4	1.0	0.5
Family relationship satisfaction	0.2	0.3	0.4	0.6	-0.2	0.6	-0.4	0.6
Knee pain experienced in last month	0.2	0.4	1.1	-0.3	-1.1	-0.8	0.2	-0.1
Diabetes diagnosed by doctor	0.2	0.3	1.1	0.2	-0.2	0.3	1.0	0.2
Medication for cholesterol	0.2	0.3	0.8	-0.3	-0.4	0.3	-0.9	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.9	-0.3	-0.0	-0.2	0.9	-0.7
Medication: Aspirin	0.2	0.2	1.0	0.3	0.2	0.2	1.0	0.1
Tinnitus: Yes, now most or all of the time	0.2	0.3	0.7	0.6	0.1	-0.1	0.8	0.5
Commuting to job workplace: Public transport	0.2	0.2	0.6	-0.3	0.4	0.7	-0.2	-0.3
Medication: Blood pressure	0.2	0.3	0.5	-0.6	-0.1	-0.7	0.7	-0.6
Irritability	0.2	0.4	0.7	-0.9	-0.5	-0.7	0.3	-0.6
Ever depressed for a whole week	0.2	0.3	0.6	-0.4	-0.4	-0.5	0.8	-0.3
Unable to work because of sickness or disability	0.2	0.3	1.2	0.2	-0.3	-0.0	1.1	0.2
Vascular/heart problems diagnosed by doctor	0.2	0.6	1.3	0.5	0.9	1.1	0.1	0.7
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.8	-0.6	-0.4	-0.1	-0.9	-0.5
Schizophrenia (2018)	0.1	0.2	0.7	-0.5	-0.3	-0.2	-0.8	-0.2
Schizophrenia vs Biploar Disorder	0.1	0.1	0.3	0.4	0.5	0.1	0.5	0.1
Crohns Disease (2017)	0.1	0.1	0.3	0.2	-0.2	0.2	0.6	0.3
Irritable Bowel Disease (IBD)	0.1	0.2	0.6	-0.2	-0.8	-0.4	0.0	-0.3
Mean Putamen Volume	0.1	0.1	0.2	0.2	0.3	-0.4	0.4	0.0
HbA1C	0.1	0.1	0.4	-0.0	0.4	0.1	0.7	-0.1
Schizophrenia (2014)	0.1	0.2	0.6	-0.4	-0.4	-0.3	-0.8	-0.3
Ulcerative Colitis	0.1	0.2	0.4	0.5	-0.7	0.2	0.4	0.2
Blood Eosinophil Count	0.1	0.6	2.0	-0.2	-0.9	-0.0	-1.4	-0.2
Blood Platelet Count	0.1	1.2	3.1	-0.8	-1.2	-0.7	-1.8	-0.6
Blood White Count	0.1	0.8	3.0	-0.7	-0.3	-0.3	-1.7	-0.4
Smoking Status	0.1	0.2	0.6	-0.6	-0.2	-0.0	-0.1	-0.8
Hypothyroidism (self reported)	0.1	0.1	0.6	0.2	0.0	-0.2	0.8	0.2
Average weekly spirits intake	0.1	0.1	0.2	-0.2	-0.3	-0.5	0.1	-0.2
Medication: Co-codamol	0.1	0.1	0.2	-0.4	0.1	-0.3	0.3	-0.1
Average weekly fortified wine intake	0.1	0.1	0.2	0.0	-0.1	0.5	-0.4	-0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.4	0.1	0.1	0.0	0.6	0.2
Age when periods started (menarche)	0.1	0.2	0.4	0.2	-0.6	-0.3	0.5	0.1
Bilateral oophorectomy (both ovaries removed)	0.1	0.2	0.3	-0.5	0.2	-0.5	0.2	-0.5
Supplements: Glucosamine	0.1	0.1	0.2	-0.2	-0.4	-0.4	-0.4	-0.3
Alcohol usually taken with meals	0.1	0.1	0.3	0.3	0.3	0.4	-0.2	0.6
Nervous feelings	0.1	0.1	0.4	0.1	-0.2	0.1	0.6	-0.2
Had other major operations	0.1	0.1	0.3	-0.4	-0.1	-0.6	0.2	0.2
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.6	-0.1	-0.2	-0.8	0.0	0.1
Qualifications: None of the above	0.1	0.2	0.5	0.4	-0.7	-0.2	-0.4	0.1
Heart attack	0.1	0.1	0.3	0.6	-0.1	-0.5	0.1	0.3
Medication: Ramipril	0.1	0.2	0.4	0.6	-0.3	0.5	0.5	0.1
Medication: Simvastatin	0.1	0.2	0.4	0.7	0.2	0.4	0.5	-0.0
Neuroticism score	0.1	0.2	1.0	-0.3	-0.1	-0.1	1.0	-0.3
Exposure to tobacco smoke at home	0.1	0.1	0.4	0.4	-0.1	0.2	0.6	0.2
Tense / ‘highly strung’	0.1	0.2	0.8	-0.4	-0.9	-0.3	-0.3	-0.3
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.2	-0.4	0.3	0.1	-0.2	-0.4
High blood pressure (siblings)	0.1	0.2	0.6	0.3	0.0	0.3	0.0	0.8
Leg fat percentage (right)	0.1	0.4	1.0	-0.3	-0.6	-0.5	-1.0	-0.0
Worry too long after embarrassment	0.1	0.2	0.5	0.1	-0.3	0.2	0.7	0.4
Wheeze or whistling in the chest in last year	0.1	0.1	0.2	-0.1	-0.4	-0.4	-0.5	0.1
Age at first live birth	0.1	0.2	0.8	0.1	-0.4	-0.0	-0.9	-0.1
Qualifications: College or University degree	0.1	0.4	1.1	0.6	0.3	1.1	-0.0	0.7
Neck or shoulder pain in last month	0.1	0.1	0.4	-0.1	-0.6	0.0	0.3	-0.0
Medication: Allopurinol	0.1	0.2	0.5	-0.3	-0.5	-0.1	-0.7	-0.3
Comparative height size at age 10	0.1	0.6	1.9	-0.7	-0.1	-0.5	-1.4	-0.6
Had major operations	0.1	0.1	0.2	-0.2	-0.4	0.3	0.3	-0.4
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.3	0.2	0.5	0.3	0.3	0.1
Medication: Aspirin	0.1	0.1	0.5	0.1	-0.3	-0.2	0.7	-0.1
Hypertension (Self-reported)	0.1	0.4	0.7	-0.6	-0.7	-0.8	0.0	-0.6
Mood swings	0.1	0.2	0.7	-0.2	0.3	0.3	0.9	0.1
Loneliness, isolation	0.1	0.1	0.2	-0.2	0.0	-0.2	0.4	-0.4
Friendships satisfaction	0.1	0.1	0.3	0.2	-0.1	0.6	0.3	0.1
Mineral and other dietary supplements	0.1	0.1	0.3	-0.1	0.4	-0.5	0.4	0.2
Miserableness	0.1	0.2	0.3	-0.3	0.0	-0.6	0.6	-0.3
Guilty feelings	0.1	0.2	0.3	0.6	0.4	0.5	0.5	0.4
Financial situation satisfaction	0.1	0.1	0.2	-0.5	0.1	0.3	0.3	-0.5
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.2	0.0	-0.4	0.2	0.2	-0.5
Medication: Bendroflumethiazide	0.1	0.2	0.5	0.1	0.5	0.3	0.7	-0.1
Medication: Lisinopril	0.1	0.1	0.3	0.2	0.1	-0.1	-0.2	0.5
Leg fat percentage (left)	0.1	0.4	1.1	-0.4	-0.7	-0.6	-1.1	-0.2
Risk taking	0.1	0.2	0.3	0.5	-0.0	0.1	-0.5	0.4
Age started oral contraceptive pill	0.1	0.2	0.4	0.4	0.1	0.5	-0.1	0.6
Cholesterol lowering medication	0.1	0.1	0.3	0.0	-0.6	-0.2	-0.0	-0.2
Basal cell carcinoma (self-reported)	0.1	0.1	0.1	0.4	0.3	0.2	0.1	0.2
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.4	0.7	0.0	-0.4	0.0	0.5
Reaction Time	0.0	0.1	0.3	0.1	-0.2	0.2	0.6	-0.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Cardiovascular Disease	0.0	0.1	0.4	0.2	-0.4	-0.6	0.4	0.2
Respiratory disease	0.0	0.1	0.4	-0.0	-0.6	0.0	0.1	0.0
Hair Pigment	0.0	0.4	1.4	-0.6	0.1	-0.1	-1.2	-0.3
Other serious medical condition/disability diagnosed by doctor	0.0	0.0	0.1	-0.0	-0.2	-0.1	0.3	0.1
Diabetes (father)	0.0	0.1	0.2	-0.1	-0.5	-0.1	0.1	-0.1
Trunk fat percentage	0.0	0.2	0.5	-0.1	-0.7	-0.5	-0.3	0.1
Maternal smoking around birth	0.0	0.0	0.1	-0.3	0.1	-0.2	-0.1	0.1
Fluid intelligence score	0.0	0.1	0.2	0.1	-0.4	-0.0	-0.3	0.3
Illnesses of siblings	0.0	0.1	0.1	0.1	0.2	0.2	-0.3	-0.3
Worrier / anxious feelings	0.0	0.1	0.2	0.0	-0.4	0.3	0.2	-0.3
Asthma	0.0	0.1	0.2	-0.1	-0.4	0.3	0.2	0.1
Standing height	0.0	0.3	1.2	-0.4	0.3	-0.2	-1.1	-0.2
Glaucoma (self-reported)	0.0	0.1	0.1	0.3	0.3	-0.2	0.2	0.2
Hypothyroidism/myxoedema (self-reported)	0.0	0.1	0.3	-0.2	-0.3	-0.5	0.1	-0.1
Body fat percentage	0.0	0.2	0.3	-0.1	-0.6	-0.5	-0.4	0.1
Smoking status: Previous	0.0	0.0	0.2	0.0	0.2	-0.1	-0.4	0.2
Mouth/teeth dental problems: Mouth ulcers	0.0	0.1	0.2	0.2	0.1	0.1	-0.2	0.5
Asthma (self-reported)	0.0	0.1	0.3	-0.2	-0.6	0.2	0.2	-0.1
Eye problems/disorders: Glaucoma	0.0	0.0	0.0	0.0	0.0	0.0	0.0	-0.1

Hub : Genes

NUP62

Models

Trait associations