[Hub]/) : Traits : Leg fat-free mass (left) : ← →

chr8:8,092,025-12,973,575

Best TWAS P=4.32e-12 · Best GWAS P=2.11e-11 conditioned to 0.638

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
44	GTEx	Esophagus Muscularis	AF131215.9	0.14	0.17	enet	16	0.17	1.6e-10	-6.0	6.9	4.3e-12	0.60	0.06	0.94	TRUE
85	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	ERI1	0.05	0.01	blup	72	0.01	5.0e-02	6.7	-6.9	4.3e-12	-0.84	0.00	0.90	TRUE
33	GTEx	Cells Transformed fibroblasts	ERI1	0.34	0.35	lasso	7	0.35	1.9e-27	6.7	-6.8	1.1e-11	-0.97	0.00	1.00	FALSE
62	GTEx	Skin Sun Exposed Lower leg	AF131215.9	0.19	0.17	enet	29	0.21	3.9e-17	-6.0	6.7	2.2e-11	0.61	0.10	0.90	FALSE
77	ROSMAP	Brain Pre-frontal Cortex	XKR6	0.11	0.10	enet	23	0.13	1.2e-16	-5.0	6.6	3.7e-11	0.63	0.18	0.82	FALSE
75	NTR	Blood	MSRA	0.02	0.01	blup	833	0.01	2.3e-05	4.5	-6.6	4.1e-11	-0.58	0.07	0.93	FALSE
47	GTEx	Heart Left Ventricle	AF131215.9	0.07	0.10	enet	8	0.10	9.4e-06	-6.0	6.5	7.9e-11	0.59	0.06	0.94	FALSE
71	GTEx	Thyroid	AF131215.2	0.11	0.15	enet	17	0.18	1.2e-13	-5.3	6.5	1.0e-10	0.60	0.16	0.84	FALSE
46	GTEx	Heart Left Ventricle	AF131215.2	0.05	0.01	enet	11	0.01	1.5e-01	6.1	6.4	1.2e-10	0.61	0.05	0.90	FALSE
53	GTEx	Pancreas	AF131215.2	0.16	0.16	enet	17	0.15	9.1e-07	-6.0	6.4	1.3e-10	0.62	0.05	0.95	FALSE
68	GTEx	Testis	AF131215.2	0.28	0.18	enet	41	0.17	8.0e-08	-5.3	6.4	1.5e-10	0.47	0.55	0.45	FALSE
81	ROSMAP	Brain Pre-frontal Cortex	AF131215.3	0.08	0.10	lasso	7	0.12	8.3e-16	5.8	6.4	1.5e-10	0.64	0.02	0.98	FALSE
54	GTEx	Pancreas	AF131215.9	0.25	0.24	enet	14	0.22	1.0e-09	5.9	6.4	1.9e-10	0.60	0.04	0.96	FALSE
40	GTEx	Esophagus Mucosa	AF131215.9	0.18	0.16	lasso	14	0.19	1.6e-12	5.8	6.3	2.3e-10	0.63	0.04	0.96	FALSE
82	ROSMAP	Brain Pre-frontal Cortex	RP11-481A20.11	0.06	0.04	blup	286	0.04	2.2e-06	5.7	6.3	2.5e-10	0.60	0.02	0.98	FALSE
16	GTEx	Artery Aorta	AF131215.9	0.13	0.05	lasso	6	0.07	1.3e-04	5.9	6.3	3.4e-10	0.61	0.05	0.94	FALSE
74	GTEx	Vagina	AF131215.9	0.21	0.11	lasso	9	0.08	6.3e-03	6.0	6.3	3.7e-10	0.57	0.05	0.91	FALSE
8	GTEx	Adipose Visceral Omentum	AF131215.9	0.18	0.16	lasso	7	0.16	2.0e-08	6.1	6.3	3.8e-10	0.61	0.02	0.98	FALSE
13	GTEx	Artery Aorta	ERI1	0.11	0.08	lasso	5	0.10	5.1e-06	6.7	-6.3	3.8e-10	-0.92	0.00	1.00	FALSE
7	GTEx	Adipose Visceral Omentum	AF131215.2	0.12	0.08	lasso	6	0.06	4.6e-04	6.1	6.3	3.9e-10	0.61	0.06	0.93	FALSE
11	GTEx	Adrenal Gland	AF131215.9	0.18	0.16	lasso	10	0.18	3.5e-07	5.9	6.3	3.9e-10	0.62	0.03	0.97	FALSE
51	GTEx	Nerve Tibial	AF131215.2	0.19	0.18	lasso	12	0.23	3.5e-16	-5.3	6.2	5.1e-10	0.60	0.16	0.84	FALSE
10	GTEx	Adrenal Gland	AF131215.2	0.20	0.16	enet	12	0.13	2.2e-05	5.9	6.2	5.6e-10	0.61	0.03	0.97	FALSE
2	CommonMind	Brain Pre-frontal Cortex	FAM86B1	0.02	0.02	lasso	3	0.01	1.3e-02	5.6	6.2	5.7e-10	0.59	0.01	0.97	FALSE
14	GTEx	Artery Aorta	AF131215.2	0.09	0.09	lasso	7	0.08	2.0e-05	-5.6	6.2	6.1e-10	0.62	0.06	0.93	FALSE
48	GTEx	Lung	AF131215.2	0.12	0.08	lasso	5	0.08	1.0e-06	-6.0	6.2	6.9e-10	0.53	0.07	0.93	FALSE
59	GTEx	Skin Not Sun Exposed Suprapubic	AF131215.9	0.17	0.14	lasso	8	0.19	9.4e-11	-6.0	6.2	6.9e-10	0.59	0.08	0.92	FALSE
37	GTEx	Colon Transverse	AF131215.9	0.12	0.14	enet	18	0.12	4.0e-06	-6.0	6.2	7.4e-10	0.55	0.06	0.94	FALSE
73	GTEx	Uterus	AF131215.2	0.17	0.07	enet	13	0.09	7.1e-03	5.9	6.1	1.0e-09	0.62	0.06	0.78	FALSE
83	ROSMAP	Brain Pre-frontal Cortex	AF131215.2	0.49	0.57	lasso	7	0.57	9.0e-89	-6.0	6.1	1.1e-09	0.53	0.06	0.94	FALSE
22	GTEx	Brain Cerebellar Hemisphere	AF131215.2	0.15	0.17	lasso	3	0.09	3.0e-03	-6.0	6.1	1.2e-09	0.56	0.07	0.76	FALSE
35	GTEx	Colon Sigmoid	AF131215.9	0.11	0.17	enet	5	0.09	4.9e-04	-6.0	6.1	1.2e-09	0.56	0.07	0.84	FALSE
39	GTEx	Esophagus Mucosa	AF131215.2	0.15	0.14	enet	15	0.18	4.3e-12	-5.3	6.1	1.3e-09	0.62	0.40	0.60	FALSE
49	GTEx	Lung	AF131215.9	0.15	0.18	lasso	4	0.15	1.5e-11	-6.0	6.1	1.4e-09	0.52	0.06	0.94	FALSE
41	GTEx	Esophagus Muscularis	ERI1	0.12	0.09	enet	13	0.08	7.7e-06	5.7	-6.0	1.6e-09	-0.86	0.07	0.93	FALSE
60	GTEx	Skin Sun Exposed Lower leg	AF131215.2	0.14	0.11	lasso	9	0.16	4.3e-13	-5.3	6.0	1.7e-09	0.58	0.28	0.72	FALSE
34	GTEx	Colon Sigmoid	AF131215.2	0.10	0.00	enet	7	0.02	5.0e-02	6.0	6.0	2.0e-09	0.64	0.10	0.60	FALSE
3	CommonMind	Brain Pre-frontal Cortex	FAM90A25P	0.11	0.08	lasso	3	0.08	1.4e-09	5.7	6.0	2.1e-09	0.54	0.00	1.00	FALSE
57	GTEx	Prostate	AF131215.2	0.18	0.02	lasso	6	0.02	9.6e-02	3.9	6.0	2.4e-09	0.57	0.08	0.50	FALSE
91	The Cancer Genome Atlas	Lung Adenocarcinoma	ERI1	0.06	0.04	blup	72	0.04	1.5e-05	5.4	-6.0	2.4e-09	-0.89	0.04	0.96	FALSE
5	GTEx	Adipose Subcutaneous	AF131215.2	0.24	0.15	lasso	7	0.14	3.5e-11	-5.6	5.9	3.0e-09	0.59	0.20	0.80	FALSE
52	GTEx	Nerve Tibial	AF131215.9	0.17	0.17	lasso	4	0.18	5.0e-13	-6.0	5.9	3.2e-09	0.53	0.08	0.92	FALSE
72	GTEx	Thyroid	AF131215.9	0.11	0.08	enet	16	0.17	4.7e-13	-6.0	5.9	3.3e-09	0.59	0.07	0.93	FALSE
58	GTEx	Skin Not Sun Exposed Suprapubic	AF131215.2	0.16	0.11	enet	21	0.20	3.9e-11	-5.3	5.9	3.5e-09	0.61	0.07	0.93	FALSE
64	GTEx	Spleen	AF131215.2	0.16	0.08	enet	14	0.06	1.1e-02	-6.0	5.9	3.6e-09	0.60	0.04	0.89	FALSE
31	GTEx	Cells EBV-transformed lymphocytes	AF131215.2	0.20	0.10	enet	14	0.11	1.5e-04	-6.0	5.9	4.0e-09	0.61	0.11	0.87	FALSE
70	GTEx	Thyroid	SGK223	0.19	0.35	enet	16	0.36	1.1e-28	5.3	-5.9	4.8e-09	-0.69	0.03	0.97	FALSE
86	The Cancer Genome Atlas	Breast Invasive Carcinoma	RP1L1	0.02	0.01	lasso	2	0.01	4.1e-03	5.5	5.8	6.0e-09	0.49	0.01	0.84	FALSE
26	GTEx	Breast Mammary Tissue	AF131215.2	0.16	0.15	lasso	6	0.12	1.1e-06	-5.6	5.7	9.0e-09	0.64	0.22	0.76	FALSE
65	GTEx	Spleen	AF131215.9	0.34	0.23	enet	16	0.15	1.2e-04	6.4	5.7	1.1e-08	0.56	0.02	0.97	FALSE
30	GTEx	Breast Mammary Tissue (Female)	AF131215.9	0.04	-0.01	enet	6	0.02	7.3e-02	-4.4	5.7	1.2e-08	0.62	0.08	0.19	FALSE
18	GTEx	Artery Tibial	AF131215.2	0.07	0.03	enet	24	0.05	1.8e-04	-6.0	5.7	1.4e-08	0.55	0.07	0.92	FALSE
32	GTEx	Cells EBV-transformed lymphocytes	AF131215.9	0.20	0.15	enet	19	0.13	5.6e-05	-6.0	5.7	1.4e-08	0.59	0.10	0.87	FALSE
61	GTEx	Skin Sun Exposed Lower leg	FAM85A	0.09	0.04	enet	28	0.04	1.4e-04	-4.6	5.7	1.4e-08	0.44	0.08	0.85	FALSE
79	ROSMAP	Brain Pre-frontal Cortex	FAM66A	0.23	0.26	enet	29	0.30	4.7e-39	5.9	5.7	1.4e-08	0.53	0.00	1.00	FALSE
24	GTEx	Brain Cortex	FAM86B3P	0.14	0.05	enet	9	0.07	5.1e-03	5.0	-5.7	1.5e-08	-0.62	0.06	0.71	FALSE
45	GTEx	Heart Atrial Appendage	AF131215.2	0.39	0.13	enet	26	0.21	6.6e-10	-5.3	5.7	1.6e-08	0.59	0.40	0.60	FALSE
17	GTEx	Artery Tibial	ERI1	0.05	0.02	lasso	7	0.01	3.2e-02	4.4	-5.6	1.7e-08	-0.82	0.02	0.95	FALSE
66	GTEx	Stomach	AF131215.9	0.14	0.06	enet	19	0.06	6.7e-04	-6.0	5.6	1.7e-08	0.53	0.04	0.95	FALSE
28	GTEx	Breast Mammary Tissue	AF131215.9	0.10	0.10	lasso	8	0.12	8.7e-07	-4.3	5.6	1.8e-08	0.64	0.14	0.86	FALSE
76	ROSMAP	Brain Pre-frontal Cortex	FAM167A	0.12	0.03	bslmm	620	0.08	1.3e-10	2.0	-5.6	2.2e-08	-0.55	0.38	0.62	FALSE
38	GTEx	Esophagus Gastroesophageal Junction	AF131215.2	0.13	0.06	enet	10	0.11	6.4e-05	4.7	5.6	2.3e-08	0.61	0.09	0.84	FALSE
84	ROSMAP	Brain Pre-frontal Cortex	FAM85A	0.11	0.07	enet	23	0.11	4.3e-14	5.9	5.6	2.4e-08	0.56	0.00	1.00	FALSE
9	GTEx	Adrenal Gland	FAM86B3P	0.16	0.00	enet	18	0.03	2.2e-02	5.0	-5.5	2.9e-08	-0.43	0.06	0.22	FALSE
88	The Cancer Genome Atlas	Breast Invasive Carcinoma	TNKS	0.02	0.00	blup	130	0.01	2.1e-02	4.1	5.5	3.1e-08	0.36	0.02	0.21	FALSE
25	GTEx	Brain Frontal Cortex BA9	FAM86B3P	0.16	0.13	enet	27	0.10	1.1e-03	5.3	-5.5	3.2e-08	-0.59	0.05	0.87	FALSE
90	The Cancer Genome Atlas	Brain Lower Grade Glioma	FLJ10661	0.21	0.26	lasso	9	0.30	2.3e-34	4.8	-5.5	3.3e-08	-0.60	0.03	0.96	FALSE
67	GTEx	Testis	FAM86B3P	0.15	0.14	lasso	7	0.13	2.2e-06	5.0	-5.5	3.5e-08	-0.61	0.03	0.97	FALSE
43	GTEx	Esophagus Muscularis	FAM85A	0.10	0.01	enet	20	0.04	2.7e-03	-4.5	5.5	3.6e-08	0.46	0.06	0.89	FALSE
56	GTEx	Prostate	SOX7	0.48	0.01	enet	14	0.15	1.3e-04	-3.0	5.5	3.6e-08	0.37	0.12	0.09	FALSE
42	GTEx	Esophagus Muscularis	AF131215.2	0.10	0.08	lasso	5	0.09	2.3e-06	-5.3	5.5	3.8e-08	0.57	0.46	0.52	FALSE
1	CommonMind	Brain Pre-frontal Cortex	FAM167A	0.09	0.09	lasso	6	0.13	1.4e-15	-4.5	-5.5	4.0e-08	-0.59	0.92	0.08	FALSE
93	The Cancer Genome Atlas	Testicular Germ Cell Tumors	ZNF705D	0.23	0.20	lasso	3	0.24	4.7e-09	5.9	-5.5	4.6e-08	-0.51	0.00	1.00	FALSE
23	GTEx	Brain Cerebellum	FAM86B3P	0.19	0.14	lasso	5	0.16	1.8e-05	4.8	-5.5	5.0e-08	-0.65	0.05	0.94	FALSE
12	GTEx	Artery Aorta	FDFT1	0.09	0.02	lasso	4	0.03	6.1e-03	4.2	5.4	5.1e-08	0.54	0.14	0.49	FALSE
21	GTEx	Brain Cerebellar Hemisphere	FAM86B3P	0.28	0.27	lasso	8	0.28	5.4e-08	5.2	-5.4	5.3e-08	-0.65	0.02	0.98	FALSE
4	GTEx	Adipose Subcutaneous	FDFT1	0.06	0.04	lasso	3	0.04	3.4e-04	-5.0	5.4	5.4e-08	0.45	0.34	0.59	FALSE
92	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	FLJ10661	0.25	0.18	lasso	4	0.16	4.2e-07	5.3	-5.4	5.7e-08	-0.60	0.00	1.00	FALSE
6	GTEx	Adipose Subcutaneous	AF131215.9	0.20	0.12	enet	60	0.17	1.1e-13	-5.6	5.4	6.9e-08	0.47	0.06	0.94	FALSE
87	The Cancer Genome Atlas	Breast Invasive Carcinoma	TDH	0.03	0.04	lasso	4	0.03	1.2e-07	-5.5	-5.4	8.4e-08	-0.45	0.00	1.00	FALSE
15	GTEx	Artery Aorta	FAM85A	0.11	0.06	enet	19	0.06	3.4e-04	-4.5	5.3	8.9e-08	0.54	0.15	0.77	FALSE
55	GTEx	Pituitary	FAM86B3P	0.13	0.15	lasso	4	0.13	3.5e-04	-4.8	-5.3	9.6e-08	-0.54	0.05	0.84	FALSE
69	GTEx	Testis	AF131215.9	0.12	0.21	lasso	4	0.14	5.6e-07	-5.3	5.3	1.1e-07	0.52	0.27	0.73	FALSE
20	GTEx	Artery Tibial	AF131215.9	0.08	0.01	lasso	10	0.02	1.8e-02	-3.5	5.3	1.2e-07	0.52	0.08	0.87	FALSE
50	GTEx	Muscle Skeletal	MFHAS1	0.07	0.04	lasso	4	0.04	1.4e-04	4.7	5.3	1.3e-07	0.81	0.16	0.82	FALSE
89	The Cancer Genome Atlas	Esophageal Carcinoma	FLJ10661	0.20	0.23	lasso	2	0.23	5.6e-08	5.3	5.3	1.3e-07	0.60	0.01	0.99	FALSE
63	GTEx	Small Intestine Terminal Ileum	AF131215.2	0.14	0.07	lasso	3	0.07	1.1e-02	-4.1	5.2	1.6e-07	0.54	0.08	0.67	FALSE
80	ROSMAP	Brain Pre-frontal Cortex	FAM85B	0.16	0.23	enet	18	0.22	1.8e-28	4.8	-5.2	1.9e-07	-0.63	0.28	0.71	FALSE
36	GTEx	Colon Transverse	AF131215.2	0.15	0.09	enet	32	0.07	3.1e-04	5.9	5.2	2.0e-07	0.50	0.09	0.89	FALSE
29	GTEx	Breast Mammary Tissue (Male)	FAM85A	0.14	0.03	enet	16	0.09	4.3e-03	-4.6	5.2	2.2e-07	0.46	0.06	0.51	FALSE
94	The Cancer Genome Atlas	Thyroid Carcinoma	SGK223	0.16	0.20	enet	14	0.22	6.1e-21	-4.4	-5.2	2.2e-07	-0.60	0.19	0.78	FALSE
27	GTEx	Breast Mammary Tissue	FAM85A	0.14	0.04	enet	14	0.08	4.4e-05	-4.5	5.2	2.3e-07	0.47	0.12	0.85	FALSE
78	ROSMAP	Brain Pre-frontal Cortex	FAM86B3P	0.19	0.27	bslmm	331	0.27	5.6e-35	5.0	-5.2	2.6e-07	-0.50	0.12	0.88	FALSE
19	GTEx	Artery Tibial	FAM85A	0.09	0.06	enet	18	0.08	1.5e-06	-4.6	5.1	2.9e-07	0.48	0.11	0.86	FALSE