Hub : Genes

CLIP1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Hippocampus 0.2709 0.1265 0.00700 0.138 NA 0.069 NA 0.119 0.00042 NA 1.1e-02 NA 1.0e-03
2 GTEx Pancreas 0.1780 0.0590 0.00016 0.066 NA 0.090 NA 0.100 0.00096 NA 1.2e-04 NA 5.4e-05
3 METSIM Adipose 0.0279 0.0132 0.00140 0.007 0.013 0.001 0.014 0.006 0.02400 3.7e-03 1.9e-01 0.0033 4.3e-02
4 NTR Blood 0.0181 0.0091 0.00820 0.000 0.003 0.000 0.006 0.000 0.31000 3.0e-02 5.1e-01 0.0043 5.3e-01
5 TCGA Prostate Adenocarcinoma 0.0521 0.0274 0.00010 0.034 0.045 0.041 NA 0.034 0.00018 1.5e-05 3.9e-05 NA 1.7e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 1.8 2.9 9.6 -3.1 -1.1 1.2 -1.3 -0.8
Bipolar Disorder or Schizophrenia 2.4 5.8 11.2 -3.1 -2.2 3.3 -1.3 -1.3
Depressed Affect (Nagel 2018) 0.6 1.2 2.8 0.8 1.7 -0.1 -0.6 1.5
Depression (Nagel 2018) 0.4 0.6 1.4 -1.2 0.3 1.2 -0.5 0.3
Intelligence (Savage-Jansen 2018) 0.7 2.0 4.3 0.3 -2.1 -0.1 1.1 -2.1
Neuroticism (Nagel 2018) 1.3 3.1 7.5 1.1 2.7 -0.8 0.3 2.5
Schizophrenia (2018) 1.8 3.8 11.3 -1.6 -1.9 3.4 -0.6 -1.0
Schizophrenia vs Biploar Disorder 0.4 0.6 1.9 0.5 0.2 1.4 0.7 0.4
Worry (Nagel 2018) 1.9 4.0 8.1 1.7 2.8 -0.9 0.5 2.8
Alzheimer’s Disease (in mother) 0.6 0.7 1.4 -0.7 -1.1 0.2 0.6 -1.2
Alzheimer’s Disease (in father) 0.6 0.6 3.0 -1.7 -0.2 0.4 0.1 -0.1
Alzheimer’s Disease (including proxy) 0.9 1.3 2.7 -1.7 -1.1 1.0 -0.1 -1.3
Crohns Disease (2017) 0.2 0.5 1.1 -0.4 -0.9 0.1 -1.0 -0.7
Irritable Bowel Disease (IBD) 0.1 0.3 0.7 0.2 -0.8 -0.4 -0.3 -0.7
Ulcerative Colitis (UC) 0.1 0.2 0.7 0.3 -0.1 -0.8 0.1 -0.1
Major Depression (MDD) 0.3 0.4 0.7 0.0 0.8 -0.1 -0.8 0.8
Reaction Time 1.2 2.4 5.8 0.4 -0.8 -2.1 -2.4 -1.0
Verbal and Numeric Reasoning (VNR) 0.9 2.2 5.3 0.2 -2.3 0.3 0.4 -2.3
Breast Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Ovarian Cancer 0.4 0.5 1.8 -0.1 0.2 -1.3 -0.7 -0.0
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 1.1 1.6 3.5 0.1 0.5 1.9 -1.8 1.0
Bipolar Disorder (2011) 2.6 2.5 5.8 -2.3 -0.9 2.4 -0.8 -0.5
Body Mass Index (BMI) (2010) 1.3 1.8 5.3 -0.3 -1.1 2.3 -1.3 -0.8
Coronary Artery Disease (CAD) 2.7 3.2 5.9 -0.9 -2.0 2.4 -1.3 -1.9
Crohns Disease (2012) 2.0 3.3 7.7 -0.9 -2.8 0.5 -1.0 -2.6
Mean Putamen Volume 0.7 0.8 1.9 -1.4 -0.7 0.8 -0.0 -0.8
Fasting Glucose 0.4 0.5 1.0 0.9 0.0 -0.6 1.0 -0.1
HbA1C 0.1 0.1 0.1 -0.1 0.1 0.4 -0.2 0.4
HDL Cholesterol 0.8 1.3 2.8 -0.8 -1.7 0.2 0.6 -1.6
LDL Cholesterol 1.6 2.5 8.0 2.8 0.5 -1.6 1.3 0.2
Lupus 0.9 1.3 2.2 -0.7 1.2 -1.4 -1.5 0.8
Neuroticism (2016) 5.3 7.6 12.0 2.3 3.5 -3.3 0.7 3.1
Primary Biliary Cirrhosis 0.7 1.0 2.1 0.2 1.4 -0.3 -0.8 1.4
Rheumatoid Arthritis 0.1 0.1 0.5 0.0 -0.1 -0.3 -0.7 0.0
Schizophrenia (2014) 2.8 6.1 12.0 -3.4 -2.2 3.5 -0.8 -1.4
Triglycerides 0.4 0.7 1.3 0.8 0.7 -0.9 -1.1 0.6
Type 2 Diabetes (T2D) (2012) 0.4 0.5 1.6 -0.6 -0.4 0.4 -1.3 -0.3
Ulcerative Colitis 0.2 0.3 0.6 0.4 -0.8 -0.5 0.3 -0.7
Blood Eosinophil Count 0.3 2.2 3.8 -0.6 -2.0 0.0 -1.7 -1.9
Blood Platelet Count 1.6 18.1 63.4 4.2 0.6 8.0 3.0 0.4
Blood Red Count 0.3 3.0 12.0 0.7 0.1 -1.5 3.5 -0.0
Blood White Count 0.3 2.4 8.7 -3.0 1.3 -0.5 -0.1 1.2
Heel T-Score 0.2 1.3 4.2 2.0 -0.4 -0.4 -0.8 -1.1
BMI 3.5 20.1 39.3 -6.3 -0.7 6.0 -5.0 0.4
Height 1.7 32.9 81.9 -8.6 0.7 9.1 1.2 2.6
Waist Hip Ratio (WHR) 1.8 8.1 25.8 5.1 2.0 -2.4 -1.6 1.6
Systolic Blood Pressure 1.0 5.2 18.6 4.3 0.6 -1.6 2.1 0.4
Smoking Status 0.1 0.3 0.4 -0.4 -0.6 0.5 -0.2 -0.6
Allergy or Eczema 1.7 4.4 7.9 -2.7 1.0 2.0 -2.8 1.3
Cardiovascular Disease 1.6 5.1 13.8 3.7 1.7 -1.7 -1.7 1.8
Hypothyroidism (self reported) 0.1 0.2 0.7 0.8 -0.6 0.3 -0.2 -0.2
Respiratory disease 0.2 0.4 1.1 -0.8 -0.3 1.0 -0.3 -0.4
Type 2 Diabetes (T2D) (2018) 1.0 1.9 2.8 1.4 1.7 0.1 -1.4 1.7
Lung FEV1/FVC ratio 1.0 4.8 7.0 2.6 2.4 -2.6 1.0 1.9
Lung FVC 2.1 10.9 18.9 -3.1 -4.3 2.6 -0.8 -4.3
Neuroticism 2.1 4.9 7.6 2.7 2.7 -1.7 -0.1 2.6
Chronotype (morning person) 3.3 7.7 14.8 3.0 2.5 -3.8 2.3 1.9
Hair Pigment 0.1 2.7 6.6 -1.5 -1.0 1.8 -2.6 -0.8
Tanning 0.2 2.0 2.5 -1.5 -1.6 1.3 1.0 -1.6
Hand grip strength (left) 1.6 4.2 6.8 -1.8 -2.4 2.6 0.9 -2.1
Number of treatments/medications taken 0.6 1.2 2.3 -0.4 1.3 0.5 -1.5 1.2
Average weekly spirits intake 0.1 0.2 0.4 0.2 -0.2 -0.6 -0.6 -0.2
Sensitivity / hurt feelings 4.5 7.8 16.1 1.0 4.0 -2.7 0.3 3.8
Frequency of depressed mood in last 2 weeks 0.6 0.8 1.7 -1.3 -0.2 0.9 -1.1 -0.2
Hearing difficulty/problems: Yes 1.1 1.7 3.0 0.8 1.7 -1.0 -1.0 1.7
Relative age of first facial hair 1.5 3.0 5.3 0.0 -2.0 -0.9 2.3 -2.3
Other serious medical condition/disability diagnosed by doctor 2.0 2.5 7.8 -1.8 -0.6 1.0 -2.8 -0.1
Ever used hormone-replacement therapy (HRT) 0.4 0.5 0.6 -0.4 0.8 0.7 0.7 0.6
Ever had hysterectomy (womb removed) 1.5 1.7 4.0 2.0 1.1 -1.1 -0.9 1.1
Systolic blood pressure, automated reading 0.5 1.6 5.1 2.2 0.8 -0.4 1.2 0.8
Eye problems/disorders: Diabetes related eye disease 1.1 1.2 2.0 1.3 1.4 -0.5 0.7 1.4
Angina 0.5 0.7 1.7 0.0 1.3 -0.6 0.1 1.3
Medication for hormone replacement therapy 0.5 0.6 1.1 -0.7 -0.8 0.7 -0.4 -1.0
Vitamin and mineral supplements 0.6 0.8 1.8 1.3 -0.8 -0.0 1.0 -0.8
Supplements: Zinc 0.7 0.8 1.1 -1.0 0.7 0.5 -1.0 1.0
Medication: Co-codamol 2.0 2.3 3.6 -1.2 -1.3 1.8 -1.9 -1.1
Medication: Metformin 2.2 3.1 6.0 1.8 2.5 -1.0 -0.3 2.3
Diabetes (father) 0.5 0.7 3.2 0.3 0.2 0.1 -1.8 0.2
Diabetes (mother) 0.4 0.5 1.0 1.0 0.5 -0.6 0.9 0.5
Severe depression (siblings) 0.6 0.7 2.1 -1.5 -0.7 0.3 -0.7 -0.6
Pack years adult smoking proportion 0.2 0.3 0.9 -0.2 0.0 0.7 -0.9 0.0
Impedance of leg (right) 0.9 4.4 11.3 3.2 -0.1 -3.4 -0.5 -0.6
Leg fat-free mass (left) 3.7 19.7 50.0 -6.5 -0.2 7.1 -2.4 1.1
Trunk fat percentage 2.1 8.4 15.2 -3.4 0.2 3.8 -3.9 1.0
Hand grip strength (right) 1.9 5.1 8.2 -2.0 -2.7 2.9 0.3 -2.5
Townsend deprivation index at recruitment 0.8 1.2 3.8 1.9 0.8 -1.1 0.3 0.5
Current tobacco smoking 0.1 0.2 0.6 0.4 -0.2 -0.2 -0.8 -0.5
Average weekly fortified wine intake 0.9 1.0 2.1 0.3 1.4 -1.0 0.6 1.3
Maternal smoking around birth 1.4 2.0 4.8 -2.2 -0.2 1.3 -1.8 -0.2
Fed-up feelings 0.1 0.1 0.3 0.1 0.1 0.5 -0.6 -0.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.8 1.1 2.6 -1.6 0.2 1.3 -1.1 0.3
Relative age voice broke 0.4 0.6 1.5 0.2 -0.8 -1.2 0.3 -0.9
Taking other prescription medications 0.7 1.0 2.3 0.2 1.2 -0.5 -1.5 1.1
Age when periods started (menarche) 1.0 2.5 4.2 1.9 -1.3 -2.1 -0.9 -1.5
Bilateral oophorectomy (both ovaries removed) 0.2 0.3 0.8 0.6 0.1 -0.3 -0.9 0.0
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.2 0.9 -0.3 -0.2 0.3 -0.9 -0.3
Tinnitus: Yes, but not now, but have in the past 1.1 1.2 1.9 1.1 1.2 -1.4 -0.0 1.1
Qualifications: CSEs or equivalent 0.1 0.2 0.4 -0.1 -0.4 -0.5 0.0 -0.6
Serious illness, injury or assault to yourself 1.6 2.0 6.7 -2.6 0.4 -0.2 -1.5 0.8
High blood pressure 2.6 7.4 17.0 4.1 2.1 -3.5 0.3 1.7
Hayfever, allergic rhinitis or eczema 1.6 3.5 6.6 -2.6 0.4 2.1 -2.3 0.8
Multivitamins +/- minerals 0.6 0.8 1.9 -1.4 0.6 1.0 0.1 0.7
Stomach or abdominal pain in last month 0.1 0.2 0.5 0.2 0.0 -0.7 -0.6 -0.0
Supplements: Glucosamine 3.7 4.8 7.5 -2.6 -1.3 2.7 -2.7 -1.1
Diverticular disease/diverticulitis (self-reported) 0.9 1.0 2.6 1.3 -0.5 0.7 -1.6 -0.4
Medication: Atenolol 1.0 1.3 3.7 1.9 0.6 -0.8 1.2 0.5
Medication: Levothyroxine sodium 1.1 1.9 6.6 2.6 0.6 -1.2 0.7 0.8
Sitting height 1.5 10.6 27.0 -5.2 1.2 4.4 0.5 2.2
Chronic bronchitis/emphysema (father) 1.4 1.6 4.2 -1.8 0.3 -0.7 -2.0 0.3
High blood pressure (mother) 1.0 1.3 3.4 0.8 1.3 -1.8 -0.1 1.1
Body mass index (BMI) 1.6 7.0 14.3 -3.4 -0.1 3.8 -2.9 0.6
Impedance of leg (left) 0.9 4.5 11.5 3.2 -0.3 -3.4 -0.5 -0.8
Leg predicted mass (left) 3.7 19.6 49.9 -6.4 -0.2 7.1 -2.4 1.1
Trunk fat mass 3.3 14.0 29.2 -4.8 0.0 5.4 -4.0 1.1
Waist circumference 1.7 6.2 14.4 -2.4 0.4 3.8 -3.1 1.0
Number of incorrect matches in round 7.3 12.2 26.1 -1.1 5.1 -2.5 -1.4 5.0
Past tobacco smoking 0.3 0.6 1.7 1.3 -0.6 0.4 -0.6 -0.7
Alcohol usually taken with meals 0.8 1.3 4.5 0.4 1.0 -0.3 2.1 0.8
Nervous feelings 2.0 3.7 5.4 1.6 2.3 -1.2 2.0 2.3
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.5 1.5 1.2 -0.3 -0.6 0.6 -0.4
Hearing difficulty/problems with background noise 0.4 0.6 1.5 -0.2 -1.2 0.6 0.0 -1.1
Hair/balding pattern: Pattern 2 1.0 1.2 3.1 -0.1 -1.6 0.3 -0.5 -1.8
Had menopause 1.8 2.3 10.2 0.8 -0.1 0.8 3.2 0.1
Had other major operations 0.7 0.9 2.6 1.6 -0.9 0.3 0.6 -0.8
Forced vital capacity (FVC) 2.6 10.0 19.8 -4.4 -3.0 3.9 -0.7 -2.4
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.8 2.3 0.4 -1.1 -0.2 -0.3 -1.5
Ever unenthusiastic/disinterested for a whole week 0.4 0.5 2.2 -1.5 0.2 0.1 0.6 0.2
Qualifications: None of the above 3.2 6.9 16.1 4.0 1.9 -3.4 1.1 1.4
Financial difficulties in last 2 years 0.3 0.4 0.8 -0.0 -0.9 -0.7 0.2 -0.7
Mouth/teeth dental problems 4.1 6.3 12.8 -3.6 1.0 1.8 -3.5 1.4
Heart attack 1.3 1.6 2.5 -1.1 1.4 0.4 1.5 1.6
Allergy 1.0 2.4 5.5 2.4 -0.8 -1.8 1.4 -1.0
Pain all over the body in last month 2.6 2.8 5.3 -2.0 -0.5 2.1 -2.3 -0.2
Diabetes (self-reported) 1.1 1.7 3.5 0.4 1.9 0.1 -1.3 1.8
Hayfever/allergic rhinitis (self-reported) 1.0 1.3 5.4 -0.4 -0.5 0.4 -2.3 -0.7
Medication: Ramipril 1.3 1.7 2.2 1.5 1.2 -1.3 -1.2 1.3
Medication: Simvastatin 1.2 1.8 2.7 1.6 1.6 -1.0 0.2 1.6
Fluid intelligence score 0.4 0.8 1.7 -1.3 -1.1 0.2 -0.5 -0.8
Illnesses of siblings 1.9 2.6 5.9 -0.2 -2.4 0.8 0.9 -2.4
Neuroticism score 1.1 2.3 3.7 1.9 1.9 -1.0 0.3 1.8
Weight 3.7 18.2 45.6 -6.0 -0.3 6.8 -2.8 1.0
Impedance of arm (right) 0.2 0.9 1.2 0.9 -0.9 -1.0 -1.1 -1.0
Arm fat percentage (right) 2.1 8.3 16.5 -3.3 -0.0 4.1 -3.6 0.7
Trunk fat-free mass 2.8 15.9 45.6 -5.7 -0.3 6.8 -0.7 0.9
Hip circumference 3.2 13.6 30.2 -5.5 -1.0 5.5 -2.6 -0.0
Time employed in main current job 2.0 2.3 5.8 -1.5 -0.5 2.4 -1.8 -0.2
Alcohol intake versus 10 years previously 2.2 3.2 5.5 -1.0 1.9 -1.4 -2.3 2.0
Father’s age at death 2.2 2.9 4.0 -0.2 2.0 -1.9 2.0 1.7
Worrier / anxious feelings 1.0 1.9 3.9 1.5 2.0 -0.3 -0.4 1.8
Frequency of tiredness / lethargy in last 2 weeks 1.3 2.2 6.4 -2.5 0.2 1.0 -1.8 0.2
Falls in the last year 1.0 1.4 3.2 0.6 0.9 -1.4 1.8 0.9
Hair/balding pattern: Pattern 3 0.8 1.3 4.0 0.2 1.0 -0.2 2.0 1.1
Number of live births 1.6 2.2 4.1 0.8 -1.5 -0.5 2.0 -1.9
Forced expiratory volume in 1-second (FEV1) 1.3 4.4 8.3 -2.9 -2.2 2.2 -0.1 -1.9
Pulse rate 2.8 4.7 7.8 -1.6 2.5 0.5 -2.6 2.8
Happiness 0.3 0.3 0.7 0.2 0.9 -0.7 -0.0 0.6
Noisy workplace 2.2 2.7 5.0 1.4 2.2 -1.5 -0.1 2.1
Qualifications: A levels/AS levels or equivalent 0.3 0.6 1.6 0.4 -1.2 0.6 -0.2 -0.9
Serious illness, injury or assault of a close relative in last 2 years 4.4 5.1 8.6 -0.8 2.9 -2.7 0.2 2.9
Mouth/teeth dental problems: Dentures 1.8 3.0 6.1 2.5 1.9 -1.2 1.3 1.5
Asthma 0.0 0.1 0.3 -0.1 0.1 0.6 0.2 -0.1
Medication: Ibuprofen (e.g. Nurofen) 0.8 1.1 1.7 -1.3 1.0 0.2 -1.3 1.0
Medication: Cholesterol lowering 1.7 2.6 4.8 -1.1 1.9 0.7 -1.8 2.2
Depression (self-reported) 0.7 0.8 1.1 -1.1 -0.9 0.7 -0.8 -1.0
Medication: Lansoprazole 0.6 0.7 2.7 -0.3 -0.3 0.7 -1.6 -0.2
Prospective memory result 0.6 0.7 1.3 0.9 1.1 0.2 0.4 1.1
Lung cancer (father) 0.5 0.6 1.5 -1.2 0.7 0.4 -0.4 0.9
Illnesses of mother 0.2 0.3 0.6 0.4 0.6 -0.2 -0.5 0.8
Forced expiratory volume in 1-second (FEV1), Best measure 1.7 5.4 8.8 -3.0 -2.6 2.5 -0.5 -2.2
Pulse wave Arterial Stiffness index 0.3 0.4 1.7 0.0 -0.3 1.3 -0.1 -0.2
Impedance of arm (left) 0.3 1.5 3.6 1.9 -0.5 -1.7 -0.6 -0.7
Arm fat mass (right) 3.1 12.6 27.4 -4.7 0.1 5.2 -3.5 1.0
Trunk predicted mass 2.8 15.9 45.5 -5.7 -0.2 6.7 -0.7 1.0
Standing height 1.8 18.3 50.1 -6.3 -0.5 7.1 -0.3 0.9
Length of working week for main job 0.9 1.0 1.8 0.1 -1.3 0.3 -1.4 -1.2
Exposure to tobacco smoke at home 0.8 0.9 2.5 -1.2 0.3 1.6 -0.6 0.5
Breastfed as a baby 1.0 1.3 4.1 -1.2 0.5 -0.1 2.0 0.7
Tense / ‘highly strung’ 0.6 1.0 2.5 0.3 1.4 0.1 -0.5 1.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.5 1.4 -0.9 0.0 0.4 -1.2 0.1
Hair/balding pattern: Pattern 4 0.0 0.1 0.3 -0.1 0.3 0.0 0.2 0.6
Birth weight of first child 0.5 0.8 2.6 -1.1 -0.3 1.6 -0.3 0.1
Peak expiratory flow (PEF) 0.3 0.8 1.6 0.3 -1.3 0.3 0.6 -1.3
Pulse wave reflection index 1.0 1.2 2.4 -0.3 -1.6 1.0 0.5 -1.5
Ever highly irritable/argumentative for 2 days 0.1 0.1 0.3 -0.1 0.4 0.2 -0.5 0.5
Loud music exposure frequency 1.3 1.5 3.4 -0.7 1.7 -0.1 0.7 1.8
Qualifications: O levels/GCSEs or equivalent 1.2 1.9 4.9 -0.7 -1.5 0.0 2.2 -1.3
Mouth/teeth dental problems: Bleeding gums 3.9 5.1 8.2 1.2 -2.9 0.1 2.8 -2.8
Blood clot in the leg (DVT) 0.5 0.7 2.4 -1.5 -0.1 1.0 0.1 -0.2
Medication: Paracetamol 1.3 2.1 4.3 2.1 -1.1 -1.4 1.2 -1.3
Headache pain in last month 1.3 2.3 8.7 0.2 -0.9 -0.6 3.0 -1.2
Medication for cholesterol, blood pressure or diabetes 1.4 2.3 4.3 0.8 -2.0 -0.0 1.7 -2.1
Glaucoma (self-reported) 1.1 1.3 1.9 -1.4 1.1 -0.9 -1.2 1.1
Gout (self-reported) 2.1 2.8 4.6 1.8 -1.3 -2.1 1.4 -1.7
Hypothyroidism/myxoedema (self-reported) 0.4 0.7 3.2 1.8 -0.1 -0.5 0.3 0.1
Medication: Amlodipine 0.4 0.6 1.8 1.3 -0.1 -0.3 1.0 -0.3
Medication: Ventolin 100micrograms inhaler 0.4 0.6 1.1 0.1 1.0 0.0 -0.8 1.1
Birth weight 0.7 1.5 2.6 -1.5 -0.5 1.5 1.6 -0.3
Chronic bronchitis/emphysema (mother) 0.3 0.3 0.8 0.4 -0.6 0.2 0.9 -0.6
High blood pressure (siblings) 2.1 3.0 5.3 -0.3 2.3 -1.5 -1.4 2.3
Forced vital capacity (FVC), Best measure 3.5 12.7 22.9 -4.8 -3.6 4.1 -1.4 -3.0
Body fat percentage 2.2 8.5 16.3 -3.3 0.1 3.8 -4.0 0.9
Leg fat percentage (right) 1.6 6.0 13.7 -2.4 0.3 3.1 -3.7 1.0
Arm fat-free mass (right) 2.5 12.9 35.1 -5.2 -0.2 5.9 -1.2 0.8
Exposure to tobacco smoke outside home 0.3 0.4 1.1 1.1 0.4 -0.1 0.1 0.7
Comparative body size at age 10 0.7 2.1 6.0 0.1 0.8 2.5 -1.3 1.4
Number of full brothers 1.5 1.8 4.9 0.3 -1.9 -0.8 -0.1 -2.2
Worry too long after embarrassment 0.7 1.2 2.7 1.7 0.4 -1.6 0.9 0.0
Seen a psychiatrist for nerves, anxiety, tension or depression 2.6 3.4 8.1 -1.9 -1.4 1.1 -2.8 -1.4
Wheeze or whistling in the chest in last year 0.7 1.2 2.5 0.3 1.6 -1.3 0.5 1.2
Number of children fathered 1.4 1.6 7.3 0.7 -0.3 -0.3 2.7 -0.2
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.6 1.1 -0.7 1.0 0.5 -0.1 1.0
Age at first live birth 1.3 2.3 3.7 -1.5 1.4 1.9 -0.5 1.9
Pulse wave peak to peak time 0.2 0.2 0.6 -0.5 0.4 -0.8 0.2 0.4
Health satisfaction 2.8 3.6 5.8 -2.1 1.9 0.7 -2.4 2.0
Shortness of breath walking on level ground 0.9 1.1 2.4 -1.5 -0.0 1.0 -1.6 0.2
Qualifications: College or University degree 1.2 3.9 8.6 -2.1 -2.0 2.9 -0.1 -1.5
Eye problems/disorders: None of the above 0.8 0.9 3.0 -0.1 -0.2 1.7 -1.2 -0.0
Mouth/teeth dental problems: Loose teeth 2.7 3.2 8.2 0.8 -0.7 -2.9 2.4 -1.1
Emphysema/chronic bronchitis 3.1 3.4 6.5 -1.6 2.5 -1.1 -0.9 2.6
Medication for pain relief, constipation, heartburn 0.1 0.1 0.5 -0.7 0.3 0.1 0.2 0.4
Neck or shoulder pain in last month 0.9 1.2 2.7 0.1 1.6 -1.2 -0.2 1.4
Medication: Blood pressure 0.8 1.4 3.9 -0.2 1.2 -0.6 -2.0 1.2
Angina (self-reported) 0.5 0.7 1.6 0.0 1.3 -0.5 0.1 1.2
Migraine (self-reported) 1.8 2.2 3.7 1.8 1.3 -1.9 1.0 1.2
Medication: Ibuprofen 1.3 1.5 2.7 -1.0 1.6 0.1 -1.1 1.6
Medication: Allopurinol 2.6 3.5 9.1 2.4 -0.4 -3.0 1.4 -0.8
Medication: Omeprazole 0.4 0.5 2.1 -0.7 0.2 -0.0 -1.4 0.2
Medication: Seretide 50 evohaler 0.5 0.6 1.0 1.0 -0.7 0.2 0.9 -0.6
Mean time to correctly identify matches 0.7 1.4 4.5 1.1 -0.1 -2.1 -1.1 -0.3
Heart disease (mother) 0.9 1.1 4.8 -0.8 0.2 0.5 -2.2 0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.7 1.2 0.4 -0.9 -0.7 1.0 -1.1
Whole body fat mass 3.1 13.1 26.8 -4.7 0.0 5.2 -4.0 1.1
Leg fat mass (right) 2.9 11.2 22.0 -4.3 0.3 4.7 -3.8 1.2
Arm predicted mass (right) 2.5 12.6 36.1 -5.0 -0.2 6.0 -1.2 0.9
Pulse rate, automated reading 1.8 5.7 12.9 -2.5 0.8 2.7 -3.6 1.3
Alcohol intake frequency. 3.1 7.1 12.6 1.1 2.9 -1.9 -3.5 3.0
Comparative height size at age 10 1.9 10.6 31.4 -4.2 0.7 5.6 0.7 1.7
Number of full sisters 2.6 3.1 8.0 -0.8 -2.6 -0.1 0.1 -2.8
Suffer from ‘nerves’ 1.2 1.9 4.1 1.3 2.0 -0.9 0.0 1.8
Overall health rating 0.7 1.6 3.2 0.2 1.5 -1.8 -0.8 1.3
Chest pain or discomfort 0.6 0.9 1.5 -1.2 1.1 -0.4 0.4 1.2
Had major operations 0.4 0.4 1.3 -1.1 -0.6 0.1 -0.1 -0.6
Age at last live birth 1.2 1.8 4.7 -1.6 0.5 2.2 -0.9 0.9
Family relationship satisfaction 0.3 0.4 1.0 0.7 0.2 -0.6 -1.0 -0.0
Leg pain on walking 0.3 0.4 1.0 -0.2 0.6 1.0 -0.5 0.7
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.2 0.5 -0.1 0.6 -0.5 -0.7 0.4
Commuting to job workplace: Car/motor vehicle 1.6 1.8 5.1 -2.3 -1.3 1.0 -0.5 -1.1
Illness, injury, bereavement, stress in last 2 years 1.6 1.9 4.4 2.1 -1.0 1.1 1.2 -1.2
Medication: Aspirin 0.7 0.9 1.6 1.3 0.9 0.3 1.0 0.9
Supplements: Vitamin C 1.6 1.9 5.1 -1.4 0.9 -0.9 -2.3 0.8
Knee pain experienced in last month 1.2 1.8 3.3 -0.4 1.7 0.1 -1.8 1.7
Hypertension (Self-reported) 2.4 6.6 13.8 3.7 2.3 -3.1 0.0 2.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.6 0.7 2.1 1.4 0.1 -0.7 0.9 0.0
Illnesses of father: Heart disease 0.7 0.9 2.4 -1.3 -0.2 1.6 0.7 -0.1
Illnesses of siblings: Diabetes 4.6 5.6 10.4 1.1 3.2 -2.0 1.5 3.1
Smoking status: Previous 0.2 0.3 1.0 -1.0 0.1 0.4 0.4 0.3
Forced expiratory volume in 1-second (FEV1), predicted 1.8 3.7 9.3 -2.8 -1.1 3.1 -0.2 -0.6
Whole body fat-free mass 3.1 17.7 48.7 -6.1 -0.2 7.0 -1.4 1.1
Leg fat-free mass (right) 3.5 18.7 48.7 -6.3 -0.3 7.0 -2.0 0.9
Arm fat percentage (left) 1.9 7.7 15.8 -2.9 -0.1 4.0 -3.7 0.7
Average weekly red wine intake 1.2 1.7 4.1 1.5 -0.6 1.2 2.0 -0.6
Handedness (chirality/laterality): Left-handed 0.8 1.0 4.0 -0.1 0.7 -0.2 -2.0 0.7
Mood swings 0.2 0.3 0.5 0.4 0.7 0.5 -0.0 0.7
Loneliness, isolation 0.3 0.5 0.6 0.6 0.8 0.5 -0.8 0.8
Long-standing illness, disability or infirmity 0.7 1.0 1.7 -0.9 1.1 0.0 -1.3 1.1
Ever had bowel cancer screening 0.2 0.2 0.5 0.6 -0.3 -0.7 0.3 -0.1
Diabetes diagnosed by doctor 1.4 2.2 4.5 0.4 2.1 -0.3 -1.5 2.1
Ever had stillbirth, spontaneous miscarriage or termination 1.2 1.3 4.4 0.6 0.9 -0.3 2.1 0.8
Friendships satisfaction 0.1 0.2 0.7 0.2 0.0 0.3 -0.8 -0.2
Qualifications: nursing, teaching 0.8 1.2 3.1 -1.8 0.2 0.6 -1.4 0.8
Commuting to job workplace: Walk 3.6 3.9 5.3 2.3 2.0 -2.2 -1.5 1.7
Eye problems/disorders: Cataract 0.4 0.4 1.2 -0.3 -0.5 -0.5 1.1 -0.6
Mouth/teeth dental problems: Mouth ulcers 3.6 5.7 9.8 3.1 -2.3 -1.9 1.5 -2.8
Medication for cholesterol 1.2 1.8 4.8 -2.2 -1.3 0.5 -1.0 -1.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.3 2.7 3.8 -1.7 -1.3 2.0 -2.0 -1.1
Back pain experienced in last month 1.9 2.8 6.1 -2.5 -0.3 1.4 -2.4 -0.0
Mineral and other dietary supplements 0.6 0.9 2.2 1.2 0.5 -1.5 0.4 0.4
Breast cancer (self-reported) 1.5 1.8 7.1 -0.2 -0.6 -1.1 2.7 -0.5
Asthma (self-reported) 0.0 0.1 0.3 -0.1 0.1 0.5 0.1 -0.1
Osteoporosis (self-reported) 1.3 1.6 5.4 1.2 0.4 -2.3 1.1 -0.0
Osteoarthritis (self-reported) 2.6 3.4 6.9 -2.0 -0.8 2.2 -2.6 -0.9
Medication: Aspirin 0.6 0.8 1.3 0.7 1.0 0.5 1.0 1.2
Medication: Gliclazide 0.4 0.4 1.1 0.3 0.8 0.6 -0.2 1.0
Illnesses of father: None of the above (group 1) 1.1 1.4 3.6 1.9 0.1 -1.0 1.5 -0.2
Smoking status: Current 0.1 0.1 0.5 0.1 0.1 -0.1 -0.7 -0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.9 1.9 4.1 -0.7 -2.0 1.2 -0.3 -1.9
Whole body water mass 3.1 17.6 48.8 -6.0 -0.1 7.0 -1.4 1.1
Leg predicted mass (right) 3.5 18.9 49.4 -6.4 -0.4 7.0 -1.9 0.8
Arm fat mass (left) 2.6 10.7 25.0 -4.0 0.3 5.0 -3.2 1.2
Number of self-reported non-cancer illnesses 0.5 0.9 2.3 1.5 0.5 -1.4 -0.1 0.4
Average weekly champagne plus white wine intake 1.2 1.7 4.8 -0.0 1.1 0.6 2.2 1.4
Miserableness 0.5 0.8 1.6 1.3 0.1 -1.3 0.8 -0.4
Guilty feelings 0.4 0.6 1.4 0.6 1.0 -0.1 0.1 1.2
Wears glasses or contact lenses 0.5 0.5 2.4 0.2 0.2 0.5 1.5 0.1
Ever taken oral contraceptive pill 0.2 0.3 1.1 -1.1 -0.0 0.1 0.2 -0.3
Hearing aid user 0.4 0.5 0.8 0.8 0.9 -0.5 0.2 0.8
Mother’s age at death 0.6 0.8 2.3 -1.5 0.7 0.2 0.7 0.7
Financial situation satisfaction 0.5 0.6 1.1 0.4 0.7 -1.1 -1.0 0.6
Tinnitus: Yes, now most or all of the time 0.8 0.9 1.9 0.2 1.1 -1.4 -0.2 1.1
Commuting to job workplace: Public transport 0.6 0.7 1.6 1.3 -0.9 0.6 -0.3 -0.7
Eye problems/disorders: Glaucoma 0.9 1.1 1.8 -0.8 1.3 -1.3 -0.1 1.2
Medication: Blood pressure 3.2 6.2 12.5 3.5 2.2 -1.8 2.5 2.0
Pain type(s) experienced in last month: Hip pain 1.3 1.6 4.4 -1.6 0.4 0.6 -2.1 0.7
Supplements: Fish oil (including cod liver oil) 1.2 1.5 3.7 -1.9 -0.8 1.7 -0.3 -0.6
High cholesterol (Self-reported) 0.9 1.7 3.1 1.4 1.1 -1.0 -1.8 1.0
Medication: Bendroflumethiazide 0.5 0.8 2.5 1.6 0.8 -0.1 -0.6 0.6
Medication: Paracetamol 0.8 1.2 2.3 1.5 -1.0 -0.6 1.0 -1.2
Medication: Lisinopril 0.8 1.1 2.3 -0.8 1.5 -0.0 -0.2 1.5
Medication: Atorvastatin 1.6 2.0 3.7 0.1 1.9 -0.2 -1.6 1.9
Illnesses of father: High blood pressure 0.2 0.3 0.6 0.1 0.5 -0.7 -0.8 0.5
Alcohol drinker status: Never 0.8 1.0 3.0 1.7 0.2 -1.1 -0.7 0.1
Ever smoked 0.5 0.8 2.1 -1.1 0.4 -1.4 0.8 0.3
Basal metabolic rate 3.4 18.9 50.4 -6.3 -0.1 7.1 -1.9 1.2
Leg fat percentage (left) 1.6 5.9 13.1 -2.4 0.3 3.1 -3.6 0.9
Arm fat-free mass (left) 2.7 13.5 34.7 -5.3 0.5 5.9 -1.1 1.6
Number of operations (self-reported) 0.0 0.0 0.1 0.0 -0.1 0.3 -0.3 0.0
Average weekly beer plus cider intake 0.1 0.1 0.5 -0.7 -0.2 -0.2 -0.1 -0.2
Irritability 0.4 0.8 2.5 1.6 0.6 -0.8 0.4 0.3
Risk taking 1.2 1.7 3.7 -0.3 1.8 -0.7 1.0 1.9
Ever had prostate specific antigen (PSA) test 0.9 1.1 2.3 -0.5 0.7 1.5 0.9 1.2
Fractured/broken bones in last 5 years 0.7 0.9 3.1 0.7 -0.8 -0.3 1.8 -0.6
Age started oral contraceptive pill 3.5 4.4 6.8 2.6 2.0 -1.7 2.3 1.7
Diastolic blood pressure, automated reading 0.5 1.6 4.7 2.2 0.2 -1.2 -1.3 0.1
Ever depressed for a whole week 0.3 0.4 0.7 -0.8 0.7 0.3 -0.2 0.8
Unable to work because of sickness or disability 0.5 0.6 2.4 -0.0 -0.2 -0.8 -1.6 -0.0
Commuting to job workplace: Cycle 0.5 0.6 2.1 1.4 0.6 -0.1 0.5 0.7
Myopia 0.5 0.7 2.1 1.5 0.5 -0.9 -0.3 0.6
Vascular/heart problems diagnosed by doctor 2.4 6.4 16.8 -4.1 -1.6 3.3 -0.7 -1.3
Cholesterol lowering medication 1.5 2.2 8.6 2.9 0.4 -0.9 1.2 0.2
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 1.9 -0.7 0.3 -0.3 -1.4 0.4
Pain experienced in last month 0.9 1.4 4.3 2.1 -0.2 -0.8 1.4 -0.4
Supplements: Calcium 0.5 0.5 1.9 -0.4 -0.3 1.4 0.5 -0.2
Basal cell carcinoma (self-reported) 0.8 1.0 2.0 -1.0 1.3 0.1 -0.3 1.4
Heart attack/myocardial infarction (self-reported) 1.5 1.9 3.7 -1.3 1.6 0.6 1.1 1.9
Deep venous thrombosis (DVT) (self-reported) 0.7 0.9 3.1 -1.8 0.1 1.1 -0.1 -0.0
Heart disease (siblings) 1.2 1.5 6.4 -0.1 0.2 0.9 -2.5 0.4
Alcohol drinker status: Previous 4.4 5.0 10.6 1.1 3.1 -1.7 0.8 3.2
Pack years of smoking 0.1 0.2 0.4 -0.4 0.2 0.6 -0.6 0.2
Impedance of whole body 0.7 3.4 8.7 2.7 -0.4 -2.9 -0.6 -0.8
Leg fat mass (left) 3.0 11.7 23.7 -4.4 0.3 4.9 -3.7 1.3
Arm predicted mass (left) 2.7 13.8 35.7 -5.4 0.5 6.0 -1.2 1.6