[Hub]/) : Traits : Trunk fat-free mass :

chr2:231,564,626-234,434,621

Best TWAS P=3.39e-16 · Best GWAS P=1.72e-14 conditioned to 0.606

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Artery Aorta B3GNT7 0.30 0.20 lasso 6 0.16 3.2e-09 -5.0 5.1 2.8e-07 -0.01 1.00 0.00 TRUE
2 GTEx Artery Coronary RP11-690I21.1 0.24 -0.01 lasso 8 -0.01 6.8e-01 -5.8 6.0 2.1e-09 -0.60 0.07 0.13 FALSE
3 GTEx Brain Cerebellar Hemisphere PTMA 0.28 0.12 enet 19 0.06 1.5e-02 -5.9 6.4 1.4e-10 -0.48 0.05 0.51 FALSE
4 GTEx Brain Frontal Cortex BA9 C2orf82 0.24 0.16 lasso 10 0.12 3.9e-04 -4.9 5.7 1.3e-08 0.02 0.04 0.93 FALSE
5 GTEx Brain Putamen basal ganglia C2orf82 0.28 0.22 lasso 3 0.18 5.3e-05 -5.0 5.9 4.7e-09 0.01 0.04 0.78 FALSE
6 GTEx Heart Atrial Appendage COPS7B 0.22 0.01 lasso 6 0.01 1.3e-01 -5.9 -6.5 6.5e-11 0.66 0.05 0.21 FALSE
7 GTEx Liver PDE6D 0.21 0.10 lasso 4 0.09 1.8e-03 -7.7 -8.2 3.4e-16 0.81 0.01 0.90 TRUE
8 GTEx Thyroid GIGYF2 0.08 0.02 lasso 3 0.01 6.7e-02 -6.2 -5.7 1.5e-08 -0.02 0.11 0.08 FALSE
9 ROSMAP Brain Pre-frontal Cortex NCL 0.16 0.05 lasso 6 0.08 6.1e-10 4.2 6.9 4.0e-12 0.06 0.01 0.99 TRUE
10 ROSMAP Brain Pre-frontal Cortex LINC00471 0.34 0.26 lasso 10 0.36 2.1e-48 -6.3 5.6 2.0e-08 -0.04 0.76 0.24 FALSE
11 YFS Blood EIF4E2 0.06 0.04 enet 27 0.04 2.8e-13 4.5 5.2 2.1e-07 -0.04 1.00 0.00 FALSE
12 The Cancer Genome Atlas Bladder Urothelial Carcinoma C2orf52 0.15 0.14 enet 8 0.13 3.7e-11 -6.5 6.5 9.4e-11 -0.02 0.63 0.37 FALSE
13 The Cancer Genome Atlas Breast Invasive Carcinoma C2orf52 0.19 0.22 blup 42 0.25 4.1e-50 -6.3 5.5 3.2e-08 -0.02 0.49 0.51 FALSE
14 The Cancer Genome Atlas Breast Invasive Carcinoma DIS3L2 0.05 0.02 enet 10 0.02 3.8e-05 -3.7 -6.3 3.4e-10 0.15 0.10 0.02 TRUE
15 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma C2orf52 0.28 0.12 lasso 6 0.12 2.0e-06 -6.8 7.0 2.2e-12 -0.04 0.06 0.94 FALSE
16 The Cancer Genome Atlas Colon Adenocarcinoma C2orf52 0.21 0.16 blup 42 0.24 7.1e-14 -6.3 6.6 4.5e-11 0.00 0.43 0.57 FALSE
17 The Cancer Genome Atlas Esophageal Carcinoma C2orf52 0.16 0.03 enet 6 0.10 3.3e-04 -3.1 5.4 6.1e-08 0.02 0.05 0.48 FALSE
18 The Cancer Genome Atlas Glioblastoma Multiforme C2orf52 0.28 0.12 enet 12 0.18 5.0e-06 -6.6 6.8 1.3e-11 -0.03 0.04 0.85 FALSE
19 The Cancer Genome Atlas Glioblastoma Multiforme C2orf82 0.20 0.24 lasso 8 0.20 9.1e-07 -4.9 5.2 1.9e-07 0.03 0.06 0.92 FALSE
20 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma C2orf52 0.18 0.16 blup 42 0.17 9.8e-19 -6.4 5.4 5.5e-08 0.01 0.60 0.40 FALSE
21 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma C2orf52 0.23 0.25 enet 12 0.28 2.9e-32 -6.4 6.1 9.8e-10 -0.03 0.73 0.27 FALSE
22 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma C2orf52 0.18 0.20 lasso 3 0.19 3.4e-11 -6.3 6.4 2.0e-10 -0.02 0.51 0.49 FALSE
23 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma EFHD1 0.11 0.01 blup 70 0.03 1.0e-02 5.7 8.0 9.6e-16 -0.03 0.02 0.71 TRUE
24 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma KCNJ13 0.07 0.06 enet 13 0.05 4.7e-04 -6.7 5.9 3.4e-09 0.01 0.02 0.91 FALSE
25 The Cancer Genome Atlas Brain Lower Grade Glioma C2orf52 0.32 0.25 blup 42 0.31 1.5e-35 -6.4 5.3 1.4e-07 -0.03 0.68 0.32 FALSE
26 The Cancer Genome Atlas Brain Lower Grade Glioma C2orf82 0.14 0.20 enet 6 0.19 3.1e-21 -5.0 5.3 1.3e-07 0.01 1.00 0.00 FALSE
27 The Cancer Genome Atlas Brain Lower Grade Glioma GIGYF2 0.02 0.01 lasso 3 0.01 5.3e-02 -6.7 -6.9 6.1e-12 -0.02 0.03 0.87 FALSE
28 The Cancer Genome Atlas Brain Lower Grade Glioma NGEF 0.03 0.01 blup 130 0.01 2.0e-02 -6.7 5.7 1.2e-08 0.01 0.02 0.90 FALSE
29 The Cancer Genome Atlas Liver Hepatocellular Carcinoma C2orf52 0.13 0.06 lasso 4 0.05 2.1e-03 -6.5 6.4 1.4e-10 -0.03 0.06 0.13 FALSE
30 The Cancer Genome Atlas Lung Adenocarcinoma C2orf52 0.18 0.16 enet 12 0.19 3.0e-21 -6.5 5.7 9.3e-09 -0.03 0.54 0.46 FALSE
31 The Cancer Genome Atlas Lung Adenocarcinoma CHRNG 0.04 0.00 blup 58 0.00 1.3e-01 2.4 -5.3 8.9e-08 0.12 0.01 0.29 FALSE
32 The Cancer Genome Atlas Lung Squamous Cell Carcinoma C2orf52 0.28 0.18 lasso 4 0.20 3.7e-22 -6.8 6.5 1.0e-10 -0.05 0.18 0.82 FALSE
33 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma C2orf52 0.24 0.20 lasso 3 0.20 1.4e-13 -6.3 6.3 2.6e-10 -0.02 0.62 0.38 FALSE
34 The Cancer Genome Atlas Pancreatic Adenocarcinoma C2orf52 0.32 0.21 lasso 7 0.21 3.6e-09 -6.3 6.1 8.3e-10 -0.06 0.39 0.61 FALSE
35 The Cancer Genome Atlas Pancreatic Adenocarcinoma KCNJ13 0.07 0.07 blup 36 0.06 2.4e-03 -6.7 6.5 7.1e-11 0.02 0.01 0.88 FALSE
36 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma C2orf52 0.27 0.27 lasso 5 0.28 1.7e-11 -6.5 6.6 4.0e-11 -0.01 0.41 0.59 FALSE
37 The Cancer Genome Atlas Prostate Adenocarcinoma C2orf52 0.32 0.34 blup 42 0.39 9.3e-44 -6.3 5.9 3.2e-09 0.00 0.30 0.70 FALSE
38 The Cancer Genome Atlas Prostate Adenocarcinoma GIGYF2 0.04 0.00 blup 103 0.02 2.1e-03 -5.0 -6.4 1.3e-10 0.01 0.04 0.80 FALSE
39 The Cancer Genome Atlas Skin Cutaneous Melanoma C2orf52 0.21 0.20 lasso 1 0.18 1.4e-05 -6.8 6.8 8.7e-12 -0.02 0.04 0.54 FALSE
40 The Cancer Genome Atlas Stomach Adenocarcinoma C2orf52 0.12 0.10 enet 11 0.12 5.6e-09 -6.3 6.2 6.9e-10 0.00 0.33 0.66 FALSE
41 The Cancer Genome Atlas Stomach Adenocarcinoma KCNJ13 0.09 0.06 blup 36 0.08 3.8e-06 -6.7 5.8 8.7e-09 0.02 0.01 0.98 FALSE
42 The Cancer Genome Atlas Testicular Germ Cell Tumors C2orf52 0.29 0.17 enet 10 0.19 3.2e-07 -6.5 6.3 3.2e-10 -0.04 0.29 0.56 FALSE
43 The Cancer Genome Atlas Thyroid Carcinoma C2orf52 0.45 0.31 enet 10 0.35 4.9e-35 -6.3 5.6 2.7e-08 -0.01 0.80 0.20 FALSE
44 The Cancer Genome Atlas Thyroid Carcinoma KCNJ13 0.03 0.00 blup 35 0.01 4.3e-02 5.6 -7.4 1.5e-13 -0.02 0.01 0.56 FALSE
45 The Cancer Genome Atlas Thyroid Carcinoma NGEF 0.04 0.03 enet 7 0.03 5.6e-04 5.7 -6.9 4.7e-12 0.00 0.04 0.93 FALSE