[Hub]/) : Traits : Forced vital capacity (FVC) : ← →

chr11:46,064,974-48,783,497

Best TWAS P=2.51e-12 · Best GWAS P=3.92e-11 conditioned to 0.365

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
51	ROSMAP	Brain Pre-frontal Cortex	C1QTNF4	0.05	0.06	blup	281	0.06	1.7e-08	-5.7	7.0	2.5e-12	-0.88	0.05	0.95	TRUE
54	YFS	Blood	PSMC3	0.02	0.01	blup	289	0.01	2.8e-05	-6.3	-6.8	1.0e-11	0.73	0.11	0.83	FALSE
49	ROSMAP	Brain Pre-frontal Cortex	ACP2	0.03	0.00	blup	295	0.02	1.5e-03	-5.7	-6.7	1.9e-11	0.66	0.21	0.51	FALSE
28	GTEx	Muscle Skeletal	MTCH2	0.05	0.03	enet	15	0.04	1.5e-04	-5.7	-6.6	3.3e-11	0.92	0.04	0.95	FALSE
40	GTEx	Whole Blood	C1QTNF4	0.09	0.05	lasso	3	0.03	1.4e-03	-6.6	6.6	4.0e-11	-1.00	0.01	0.98	FALSE
18	GTEx	Colon Transverse	C1QTNF4	0.07	0.02	lasso	6	0.03	2.0e-02	-6.3	6.6	4.8e-11	-0.94	0.02	0.93	FALSE
29	GTEx	Muscle Skeletal	C1QTNF4	0.09	0.14	lasso	3	0.13	9.9e-13	-6.1	6.4	1.2e-10	-0.92	0.04	0.96	FALSE
9	GTEx	Brain Cortex	MTCH2	0.21	0.19	lasso	6	0.16	4.0e-05	-6.6	-6.4	1.4e-10	0.98	0.01	0.97	FALSE
55	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	C1QTNF4	0.06	0.07	lasso	2	0.06	4.9e-06	-6.3	6.4	1.6e-10	-0.96	0.00	1.00	FALSE
77	The Cancer Genome Atlas	Stomach Adenocarcinoma	C1QTNF4	0.06	0.04	lasso	4	0.03	4.3e-03	-6.3	6.4	1.6e-10	-0.97	0.00	0.93	FALSE
59	The Cancer Genome Atlas	Esophageal Carcinoma	C1QTNF4	0.39	0.33	blup	15	0.35	6.1e-12	-6.1	6.3	2.2e-10	-0.90	0.00	1.00	FALSE
65	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C1QTNF4	0.12	0.14	enet	4	0.16	6.5e-18	-6.2	6.3	2.2e-10	-0.96	0.00	1.00	FALSE
73	The Cancer Genome Atlas	Lung Adenocarcinoma	C1QTNF4	0.03	0.02	blup	15	0.02	1.3e-03	-6.1	6.3	2.2e-10	-0.89	0.00	0.96	FALSE
48	ROSMAP	Brain Pre-frontal Cortex	MTCH2	0.35	0.40	enet	9	0.40	4.7e-56	-6.2	-6.3	2.3e-10	0.97	0.06	0.94	FALSE
15	GTEx	Cells Transformed fibroblasts	PSMC3	0.07	0.00	enet	13	0.02	2.3e-02	4.5	-6.3	2.9e-10	0.79	0.04	0.68	FALSE
47	NTR	Blood	MTCH2	0.02	0.04	lasso	1	0.04	1.3e-11	-6.3	6.3	3.0e-10	-0.97	0.02	0.98	FALSE
37	GTEx	Spleen	C1QTNF4	0.31	0.28	enet	29	0.34	1.8e-09	-6.6	6.3	3.3e-10	-0.94	0.02	0.98	FALSE
66	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	C1QTNF4	0.13	0.16	lasso	1	0.16	3.1e-09	-6.3	6.3	3.3e-10	-0.97	0.00	1.00	FALSE
42	METSIM	Adipose	C1QTNF4	0.24	0.31	lasso	7	0.31	1.2e-46	-6.2	6.2	4.2e-10	-0.97	0.06	0.94	FALSE
4	GTEx	Adipose Subcutaneous	C1QTNF4	0.16	0.22	lasso	4	0.22	2.5e-18	-6.3	6.2	4.4e-10	-0.91	0.08	0.92	FALSE
60	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C1QTNF4	0.06	0.08	lasso	3	0.08	7.5e-09	-6.2	6.2	5.4e-10	-0.97	0.00	1.00	FALSE
68	The Cancer Genome Atlas	Brain Lower Grade Glioma	MTCH2	0.11	0.11	lasso	2	0.10	6.4e-12	-6.2	-6.2	5.4e-10	0.97	0.00	1.00	FALSE
71	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	C1QTNF4	0.19	0.19	lasso	3	0.19	3.2e-09	-6.2	6.2	5.5e-10	-0.97	0.00	1.00	FALSE
21	GTEx	Heart Atrial Appendage	C1QTNF4	0.26	0.14	lasso	9	0.17	3.9e-08	-6.1	6.2	6.3e-10	-0.90	0.04	0.96	FALSE
20	GTEx	Esophagus Muscularis	C1QTNF4	0.10	0.05	enet	23	0.06	1.4e-04	-6.3	6.2	6.8e-10	-0.86	0.06	0.93	FALSE
1	CommonMind	Brain Pre-frontal Cortex	FAM180B	0.07	0.08	lasso	3	0.08	9.1e-10	-6.1	-6.2	7.1e-10	0.91	0.06	0.94	FALSE
32	GTEx	Nerve Tibial	C1QTNF4	0.20	0.23	enet	12	0.23	1.7e-16	-6.1	6.1	9.0e-10	-0.89	0.08	0.92	FALSE
17	GTEx	Cells Transformed fibroblasts	NDUFS3	0.08	0.01	lasso	2	0.01	3.3e-02	-6.3	6.1	9.8e-10	-0.84	0.03	0.86	FALSE
5	GTEx	Artery Aorta	C1QTNF4	0.09	0.10	lasso	1	0.08	3.2e-05	-6.1	6.1	1.0e-09	-0.85	0.04	0.94	FALSE
19	GTEx	Esophagus Mucosa	C1QTNF4	0.10	0.11	lasso	1	0.10	5.0e-07	-6.1	6.1	1.0e-09	-0.85	0.06	0.94	FALSE
24	GTEx	Heart Left Ventricle	C1QTNF4	0.10	0.11	lasso	1	0.09	1.1e-05	-6.1	6.1	1.0e-09	-0.85	0.08	0.76	FALSE
56	The Cancer Genome Atlas	Colon Adenocarcinoma	C1QTNF4	0.12	0.12	lasso	1	0.12	1.6e-07	-6.1	6.1	1.0e-09	-0.85	0.01	0.99	FALSE
27	GTEx	Lung	C1QTNF4	0.18	0.15	lasso	6	0.13	3.2e-10	-5.5	6.1	1.1e-09	-0.93	0.04	0.96	FALSE
33	GTEx	Skin Not Sun Exposed Suprapubic	LRP4	0.13	0.00	lasso	7	0.02	3.5e-02	4.4	6.1	1.3e-09	-0.59	0.05	0.67	FALSE
70	The Cancer Genome Atlas	Brain Lower Grade Glioma	PSMC3	0.10	0.05	blup	39	0.08	3.7e-09	-5.5	-6.0	1.8e-09	0.68	0.02	0.98	FALSE
57	The Cancer Genome Atlas	Colon Adenocarcinoma	KBTBD4	0.14	0.01	blup	13	0.02	1.6e-02	4.5	-5.9	3.1e-09	0.83	0.00	0.52	FALSE
35	GTEx	Skin Sun Exposed Lower leg	ACP2	0.16	0.14	enet	15	0.15	1.8e-12	5.5	-5.9	3.6e-09	0.43	0.75	0.25	FALSE
36	GTEx	Skin Sun Exposed Lower leg	C1QTNF4	0.25	0.22	lasso	12	0.23	4.2e-19	-6.1	5.9	4.3e-09	-0.91	0.06	0.94	FALSE
76	The Cancer Genome Atlas	Prostate Adenocarcinoma	PSMC3	0.02	0.02	blup	39	0.02	5.7e-03	-5.5	-5.8	6.2e-09	0.82	0.01	0.68	FALSE
72	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	PSMC3	0.09	0.07	blup	39	0.06	8.7e-04	-5.7	-5.8	6.8e-09	0.86	0.01	0.99	FALSE
22	GTEx	Heart Left Ventricle	MADD	0.14	0.01	enet	17	0.05	7.0e-04	4.4	-5.8	6.9e-09	0.46	0.21	0.55	FALSE
50	ROSMAP	Brain Pre-frontal Cortex	PSMC3	0.15	0.08	bslmm	285	0.10	5.1e-13	3.0	-5.8	6.9e-09	0.61	0.90	0.10	FALSE
53	YFS	Blood	NUP160	0.02	0.01	blup	290	0.01	1.7e-04	-6.6	-5.8	7.6e-09	0.80	0.02	0.97	FALSE
75	The Cancer Genome Atlas	Prostate Adenocarcinoma	NUP160	0.03	0.02	enet	7	0.02	6.3e-03	-5.7	-5.8	8.5e-09	0.94	0.01	0.90	FALSE
38	GTEx	Testis	NR1H3	0.10	0.10	lasso	6	0.08	2.9e-04	5.7	-5.7	9.8e-09	0.32	0.52	0.16	FALSE
2	CommonMind	Brain Pre-frontal Cortex	MTCH2	0.03	0.00	bslmm	299	0.00	1.1e-01	2.4	-5.7	1.0e-08	0.74	0.03	0.78	FALSE
31	GTEx	Nerve Tibial	SLC39A13	0.07	0.01	enet	14	0.02	7.6e-03	-5.6	-5.7	1.0e-08	0.69	0.13	0.34	FALSE
52	YFS	Blood	NR1H3	0.34	0.15	enet	66	0.24	3.1e-76	5.3	-5.7	1.1e-08	0.46	0.90	0.10	FALSE
63	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	NUP160	0.08	0.03	blup	42	0.04	6.7e-05	-6.4	-5.7	1.2e-08	0.91	0.01	0.97	FALSE
78	The Cancer Genome Atlas	Thyroid Carcinoma	C1QTNF4	0.04	0.01	blup	15	0.03	7.9e-04	-6.1	5.7	1.4e-08	-0.80	0.00	0.87	FALSE
43	METSIM	Adipose	MYBPC3	0.11	0.10	enet	26	0.11	1.0e-15	-5.5	5.6	1.7e-08	-0.84	0.24	0.76	FALSE
69	The Cancer Genome Atlas	Brain Lower Grade Glioma	MYBPC3	0.03	0.01	blup	43	0.02	3.2e-03	-5.7	5.6	1.7e-08	-0.75	0.01	0.88	FALSE
67	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PSMC3	0.07	0.07	enet	7	0.06	1.4e-04	-5.6	-5.6	1.8e-08	0.88	0.01	0.98	FALSE
3	GTEx	Adipose Subcutaneous	ACP2	0.08	0.03	enet	18	0.03	3.5e-03	5.5	-5.6	1.9e-08	0.54	0.24	0.35	FALSE
39	GTEx	Testis	MTCH2	0.17	0.16	lasso	3	0.16	1.0e-07	-5.5	-5.6	2.5e-08	0.90	0.07	0.93	FALSE
41	METSIM	Adipose	ACP2	0.05	0.04	blup	302	0.06	1.7e-09	-5.5	-5.5	2.9e-08	0.68	0.11	0.89	FALSE
64	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ACP2	0.03	0.03	blup	44	0.04	3.5e-05	5.7	-5.5	3.2e-08	0.30	0.01	0.99	FALSE
12	GTEx	Breast Mammary Tissue	C1QTNF4	0.10	0.06	lasso	2	0.03	8.5e-03	-5.5	5.5	3.4e-08	-0.89	0.04	0.87	FALSE
14	GTEx	Cells Transformed fibroblasts	FNBP4	0.11	0.05	lasso	8	0.08	1.6e-06	4.3	-5.5	3.6e-08	0.84	0.24	0.76	FALSE
16	GTEx	Cells Transformed fibroblasts	C1QTNF4	0.13	0.11	enet	19	0.12	5.2e-09	-6.3	5.5	3.6e-08	-0.84	0.02	0.98	FALSE
7	GTEx	Brain Cerebellar Hemisphere	ACP2	0.29	0.05	enet	16	0.12	5.9e-04	4.7	-5.5	4.0e-08	0.38	0.08	0.18	FALSE
26	GTEx	Lung	ACP2	0.04	0.03	lasso	2	0.04	4.3e-04	5.3	-5.5	4.1e-08	0.32	0.51	0.09	FALSE
23	GTEx	Heart Left Ventricle	ACP2	0.11	0.06	enet	18	0.10	9.2e-06	4.4	-5.5	4.6e-08	0.29	0.75	0.08	FALSE
30	GTEx	Nerve Tibial	PTPRJ	0.05	0.03	enet	13	0.03	2.7e-03	4.1	5.5	5.0e-08	-0.55	0.14	0.35	FALSE
13	GTEx	Breast Mammary Tissue (Female)	MADD	0.13	0.04	lasso	3	0.05	1.3e-02	-5.6	-5.4	5.3e-08	0.87	0.04	0.52	FALSE
44	METSIM	Adipose	PSMC3	0.06	0.03	enet	28	0.04	2.3e-06	-4.1	-5.4	5.3e-08	0.84	0.05	0.95	FALSE
25	GTEx	Liver	C1QTNF4	0.25	0.14	enet	16	0.20	2.3e-06	-6.1	5.4	5.9e-08	-0.83	0.03	0.94	FALSE
6	GTEx	Brain Cerebellar Hemisphere	MADD	0.44	0.14	lasso	7	0.21	4.0e-06	5.5	-5.4	6.8e-08	0.43	0.21	0.48	FALSE
45	METSIM	Adipose	RAPSN	0.11	0.01	enet	21	0.06	7.9e-09	2.4	5.4	6.8e-08	-0.28	0.74	0.25	FALSE
8	GTEx	Brain Cerebellum	MADD	0.21	0.00	enet	13	0.11	3.3e-04	3.7	-5.3	9.1e-08	0.59	0.12	0.45	FALSE
74	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	DDB2	0.02	0.03	lasso	1	0.02	1.0e-03	5.3	5.3	9.8e-08	-0.33	0.01	0.91	FALSE
10	GTEx	Brain Hypothalamus	NR1H3	0.25	0.18	lasso	5	0.10	2.7e-03	5.5	5.3	1.1e-07	-0.33	0.15	0.08	FALSE
61	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	FNBP4	0.10	0.03	blup	45	0.05	7.7e-06	-6.6	-5.3	1.4e-07	0.82	0.00	0.99	FALSE
62	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MYBPC3	0.05	0.03	blup	43	0.04	6.0e-05	-4.4	5.3	1.4e-07	-0.75	0.02	0.98	FALSE
34	GTEx	Skin Not Sun Exposed Suprapubic	C1QTNF4	0.32	0.18	enet	33	0.20	5.2e-11	-6.1	5.2	1.9e-07	-0.80	0.06	0.94	FALSE
11	GTEx	Brain Putamen basal ganglia	CKAP5	0.25	0.07	lasso	3	0.14	4.4e-04	4.7	5.2	2.0e-07	-0.44	0.06	0.14	FALSE
58	The Cancer Genome Atlas	Colon Adenocarcinoma	NUP160	0.05	0.05	blup	44	0.05	7.7e-04	4.4	-5.2	2.1e-07	0.74	0.08	0.23	FALSE
46	NTR	Blood	DDB2	0.01	0.00	lasso	7	0.01	2.2e-03	5.3	-5.2	2.4e-07	0.21	0.31	0.04	FALSE