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chr11:63,295,034-69,623,641

Best TWAS P=1.24e-15 · Best GWAS P=1.06e-15 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
5	GTEx	Artery Tibial	RAD9A	0.39	0.26	lasso	2	0.24	3.5e-19	-8.0	-8.0	1.2e-15	1.00	0.00	1.00	TRUE
11	GTEx	Esophagus Mucosa	PLCB3	0.28	0.24	lasso	6	0.23	1.1e-15	-6.2	6.5	1.0e-10	0.08	0.01	0.99	TRUE
1	GTEx	Adipose Subcutaneous	NRXN2	0.11	0.05	enet	21	0.05	3.4e-05	-5.2	-6.5	1.1e-10	0.01	0.13	0.87	TRUE
35	YFS	Blood	PPP1R14B	0.02	0.01	blup	333	0.01	1.8e-03	4.1	-5.9	3.1e-09	-0.02	0.24	0.26	TRUE
31	ROSMAP	Brain Pre-frontal Cortex	KCNK4	0.14	0.12	bslmm	334	0.11	3.0e-14	-6.0	-5.7	9.8e-09	-0.07	0.01	0.99	TRUE
27	GTEx	Uterus	PACS1	0.21	-0.01	enet	21	0.05	3.6e-02	2.9	-5.5	3.6e-08	0.15	0.06	0.34	TRUE
43	The Cancer Genome Atlas	Brain Lower Grade Glioma	C11orf20	0.08	0.07	enet	6	0.08	8.1e-10	-5.1	5.5	5.0e-08	0.06	0.00	1.00	TRUE
48	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	TRMT112	0.16	0.05	blup	28	0.04	1.2e-02	-6.3	-5.5	5.0e-08	-0.05	0.00	0.76	TRUE
38	The Cancer Genome Atlas	Glioblastoma Multiforme	CTSW	0.16	0.18	enet	16	0.19	2.3e-06	4.9	-5.4	7.8e-08	0.09	0.28	0.41	TRUE
26	GTEx	Testis	RP11-554A11.9	0.25	0.13	enet	11	0.18	2.8e-08	-4.8	5.3	1.3e-07	-0.15	0.03	0.95	TRUE
3	GTEx	Artery Aorta	PPP1R14B	0.12	0.03	lasso	4	0.08	3.0e-05	3.0	-5.2	1.6e-07	-0.06	0.05	0.91	TRUE
18	GTEx	Nerve Tibial	RAD9A	0.53	0.24	lasso	10	0.23	5.6e-16	-8.0	-8.0	1.3e-15	0.99	0.00	1.00	FALSE
25	GTEx	Testis	RAD9A	0.72	0.50	lasso	4	0.49	1.1e-24	-8.0	-8.0	1.5e-15	1.00	0.00	1.00	FALSE
14	GTEx	Esophagus Muscularis	RAD9A	0.25	0.26	lasso	2	0.26	6.2e-16	-8.0	-7.9	2.8e-15	0.99	0.00	1.00	FALSE
2	GTEx	Adipose Subcutaneous	RAD9A	0.43	0.22	lasso	6	0.23	7.1e-19	-8.0	-7.7	1.1e-14	0.97	0.00	1.00	FALSE
30	ROSMAP	Brain Pre-frontal Cortex	RAD9A	0.34	0.17	enet	21	0.20	1.1e-25	-8.0	-6.6	4.1e-11	0.89	0.00	1.00	FALSE
23	GTEx	Skin Sun Exposed Lower leg	PRDX5	0.08	0.07	enet	16	0.05	1.0e-04	-6.3	6.4	1.3e-10	0.05	0.00	0.99	FALSE
28	ROSMAP	Brain Pre-frontal Cortex	PRDX5	0.10	0.05	lasso	6	0.08	2.8e-10	-6.0	6.3	2.7e-10	0.08	0.01	0.99	FALSE
32	ROSMAP	Brain Pre-frontal Cortex	TEX40	0.25	0.23	lasso	3	0.23	2.5e-29	-6.3	6.3	2.9e-10	0.07	0.00	1.00	FALSE
49	The Cancer Genome Atlas	Thyroid Carcinoma	PRDX5	0.05	0.04	lasso	3	0.02	1.6e-03	-6.2	6.3	2.9e-10	0.07	0.00	0.95	FALSE
33	ROSMAP	Brain Pre-frontal Cortex	RP11-783K16.10	0.07	0.05	lasso	6	0.06	9.6e-08	-6.3	6.2	5.0e-10	0.07	0.01	0.99	FALSE
41	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C11orf20	0.07	0.07	lasso	4	0.07	6.4e-08	-6.3	6.2	5.6e-10	0.06	0.00	1.00	FALSE
39	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C11orf20	0.06	0.03	lasso	3	0.02	7.2e-04	-6.2	6.2	6.9e-10	0.06	0.00	0.98	FALSE
9	GTEx	Cells Transformed fibroblasts	RAD9A	0.24	0.16	lasso	3	0.16	3.6e-12	-8.0	-6.1	9.6e-10	0.92	0.00	1.00	FALSE
21	GTEx	Skin Not Sun Exposed Suprapubic	PRDX5	0.13	0.12	lasso	2	0.11	1.5e-06	-6.3	6.1	1.3e-09	0.08	0.00	0.99	FALSE
4	GTEx	Artery Tibial	NRXN2	0.17	0.12	lasso	5	0.12	6.9e-10	-5.2	-6.0	1.6e-09	-0.06	0.04	0.96	FALSE
45	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C11orf20	0.04	0.03	lasso	2	0.03	4.2e-04	-6.0	6.0	1.6e-09	0.07	0.00	0.99	FALSE
36	YFS	Blood	PRDX5	0.51	0.40	lasso	9	0.43	4.0e-157	-6.0	-5.9	4.0e-09	-0.06	0.02	0.98	FALSE
47	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	VEGFB	0.04	0.04	blup	47	0.02	8.9e-03	-4.5	5.8	5.4e-09	0.08	0.03	0.43	FALSE
29	ROSMAP	Brain Pre-frontal Cortex	CDK2AP2	0.03	0.02	enet	11	0.03	1.6e-04	-3.2	5.8	5.5e-09	-0.48	0.27	0.60	FALSE
7	GTEx	Breast Mammary Tissue (Female)	PPP1R14B	0.10	0.06	lasso	2	0.08	2.0e-03	-5.5	-5.8	6.5e-09	-0.08	0.03	0.34	FALSE
8	GTEx	Cells Transformed fibroblasts	NRXN2	0.15	0.05	lasso	4	0.06	2.0e-05	-5.2	-5.8	8.7e-09	-0.06	0.19	0.80	FALSE
10	GTEx	Colon Transverse	RAD9A	0.40	0.16	lasso	8	0.16	7.2e-08	-8.0	-5.7	1.0e-08	0.88	0.00	1.00	FALSE
20	GTEx	Skin Not Sun Exposed Suprapubic	NRXN2	0.10	0.07	enet	6	0.05	7.8e-04	-5.2	-5.6	2.4e-08	-0.07	0.55	0.29	FALSE
17	GTEx	Nerve Tibial	NRXN2	0.08	0.05	lasso	4	0.07	2.0e-05	-5.3	-5.5	4.2e-08	-0.05	0.26	0.69	FALSE
22	GTEx	Skin Sun Exposed Lower leg	NRXN2	0.11	0.05	enet	27	0.08	7.0e-07	-5.2	-5.5	4.6e-08	-0.05	0.06	0.94	FALSE
12	GTEx	Esophagus Muscularis	TCIRG1	0.10	0.09	lasso	2	0.06	8.7e-05	-4.3	5.4	8.1e-08	-0.43	0.01	0.67	FALSE
19	GTEx	Pancreas	TRPT1	0.10	0.05	lasso	3	0.01	7.8e-02	-4.7	-5.3	9.0e-08	-0.07	0.04	0.62	FALSE
16	GTEx	Muscle Skeletal	RAD9A	0.12	0.02	lasso	4	0.03	4.2e-04	-8.0	-5.3	9.5e-08	0.83	0.00	0.99	FALSE
46	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	VEGFB	0.06	0.00	blup	47	0.02	3.9e-03	-3.6	5.3	1.1e-07	0.08	0.02	0.05	FALSE
34	ROSMAP	Brain Pre-frontal Cortex	RP11-783K16.13	0.24	0.16	enet	11	0.16	1.1e-19	-5.0	-5.3	1.4e-07	-0.07	0.82	0.18	FALSE
40	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	DKFZp761E198	0.07	0.02	blup	39	0.03	5.9e-04	-5.6	-5.2	1.7e-07	0.16	0.02	0.60	FALSE
42	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SLC22A12	0.05	0.02	blup	38	0.03	6.3e-03	-4.5	-5.2	1.7e-07	-0.07	0.01	0.69	FALSE
6	GTEx	Breast Mammary Tissue (Male)	GSTP1	0.11	-0.01	lasso	2	-0.01	7.7e-01	-3.4	5.2	1.9e-07	-0.40	0.02	0.42	FALSE
37	The Cancer Genome Atlas	Breast Invasive Carcinoma	NRXN2	0.01	0.02	lasso	3	0.01	5.1e-04	-5.2	-5.2	1.9e-07	-0.06	0.06	0.50	FALSE
24	GTEx	Spleen	NRXN2	0.46	0.12	lasso	5	0.10	1.3e-03	-5.2	-5.2	2.1e-07	-0.06	0.24	0.29	FALSE
13	GTEx	Esophagus Muscularis	TRPT1	0.20	0.12	enet	18	0.15	2.3e-09	-3.7	-5.2	2.4e-07	-0.06	0.43	0.56	FALSE
15	GTEx	Liver	CDK2AP2	0.30	-0.01	lasso	7	-0.01	4.9e-01	-2.5	-5.1	2.7e-07	0.46	0.02	0.47	FALSE
44	The Cancer Genome Atlas	Lung Adenocarcinoma	NRXN2	0.07	0.06	enet	9	0.06	6.2e-08	-5.3	-5.1	3.0e-07	-0.01	0.14	0.85	FALSE