Hub : Genes

SLC16A3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.0754	0.0390	3.0e-03	0.062	NA	0.015	NA	0.039	1.2e-05	NA	2.1e-02	NA	4.8e-04
2	GTEx	Thyroid	0.1780	0.0410	1.0e-07	0.202	NA	0.192	NA	0.182	2.2e-15	NA	1.1e-14	NA	6.7e-14
3	TCGA	Brain Lower Grade Glioma	0.0230	0.0166	8.4e-03	0.014	0.006	0.019	NA	0.002	9.8e-03	6.4e-02	2.5e-03	NA	1.6e-01
4	TCGA	Prostate Adenocarcinoma	0.1850	0.0736	1.3e-08	0.035	0.089	0.089	NA	0.074	1.2e-04	1.6e-09	1.4e-09	NA	3.3e-08
5	TCGA	Thyroid Carcinoma	0.1150	0.0480	6.1e-07	0.066	0.078	0.082	NA	0.081	5.3e-07	4.4e-08	2.2e-08	NA	2.7e-08

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.1	0.1	0.4	0.6	-0.6	0.0	0.0	0.0
Bipolar Disorder or Schizophrenia	0.6	1.5	3.4	1.8	-0.0	-1.0	-1.6	-0.6
Depressed Affect (Nagel 2018)	0.4	0.8	1.8	0.2	1.3	0.4	0.7	1.3
Depression (Nagel 2018)	1.1	1.7	2.8	0.6	1.6	1.2	1.1	1.7
Intelligence (Savage-Jansen 2018)	0.7	2.2	7.7	-1.4	-0.9	2.8	-0.0	-0.7
Neuroticism (Nagel 2018)	1.2	2.9	6.6	1.4	2.6	-0.5	0.9	2.3
Schizophrenia (2018)	0.6	1.2	3.6	1.9	0.4	-1.3	-0.7	0.2
Schizophrenia vs Biploar Disorder	0.6	0.8	3.5	1.9	0.7	0.0	0.0	0.0
Worry (Nagel 2018)	1.3	2.7	6.4	1.7	2.5	-0.8	0.3	1.9
Alzheimer’s Disease (in mother)	2.1	2.4	5.2	-2.3	-2.1	0.6	-0.7	-1.3
Alzheimer’s Disease (in father)	0.4	0.5	0.8	-0.7	-0.8	-0.8	-0.0	-0.9
Alzheimer’s Disease (including proxy)	1.9	2.8	6.2	-1.6	-2.5	0.5	-1.1	-1.9
Crohns Disease (2017)	0.2	0.5	1.4	0.9	0.3	-1.2	0.0	0.3
Irritable Bowel Disease (IBD)	0.4	0.8	1.7	0.6	1.3	-0.1	0.9	1.1
Ulcerative Colitis (UC)	1.0	1.9	3.5	-0.2	1.9	0.7	1.7	1.7
Major Depression (MDD)	0.8	0.9	4.6	0.0	2.1	0.0	0.0	0.0
Reaction Time	0.4	0.7	2.9	1.7	0.5	-0.1	-0.7	0.2
Verbal and Numeric Reasoning (VNR)	0.3	0.7	2.2	-0.7	0.3	1.5	0.8	0.5
Breast Cancer	0.7	1.7	2.7	0.9	1.6	-0.4	1.6	1.6
Ovarian Cancer	0.2	0.2	0.7	-0.1	0.2	0.5	0.1	0.9
Prostate Cancer	3.9	5.5	10.5	-0.8	-3.2	1.1	-2.2	-3.2
Age at First Birth	0.2	0.3	0.8	-0.9	-0.7	0.2	0.6	-0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	4.2	5.8	7.3	-2.7	-2.7	1.0	-2.6	-2.6
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.2	0.3	1.4	0.6	1.2	0.0	0.0	0.0
Mean Putamen Volume	0.7	0.8	3.4	-0.1	0.3	0.7	1.8	0.1
Fasting Glucose	0.9	1.0	1.9	0.0	1.3	-0.2	1.4	1.2
HbA1C	4.0	4.4	6.1	-0.8	-2.1	2.5	-2.4	-2.3
HDL Cholesterol	0.7	1.1	3.2	-1.8	-0.8	1.1	0.6	-0.1
LDL Cholesterol	3.2	5.0	12.8	-0.7	-2.3	0.3	-3.6	-2.5
Lupus	0.4	0.6	1.1	0.6	0.7	-1.1	-0.9	0.5
Neuroticism (2016)	2.8	4.0	7.7	1.7	2.6	-0.3	1.6	2.8
Primary Biliary Cirrhosis	0.4	0.5	1.2	0.7	1.1	-0.6	0.0	0.8
Rheumatoid Arthritis	0.8	1.1	1.9	1.0	1.4	-1.4	0.0	0.8
Schizophrenia (2014)	1.3	2.8	8.6	2.9	-0.1	-1.3	-1.8	-0.7
Triglycerides	2.9	4.7	7.7	-1.3	-2.7	0.4	-2.6	-2.8
Type 2 Diabetes (T2D) (2012)	0.3	0.3	1.0	-1.0	-0.8	0.0	0.0	0.0
Ulcerative Colitis	1.1	1.6	4.5	0.3	2.1	-0.1	0.0	1.9
Blood Eosinophil Count	0.8	6.1	10.3	-3.2	-3.0	2.2	-0.9	-2.3
Blood Platelet Count	0.1	1.5	3.3	-0.1	-1.3	-0.2	-1.6	-1.8
Blood Red Count	0.7	6.5	15.3	-0.2	3.2	0.7	3.9	2.5
Blood White Count	0.1	0.8	2.2	-0.5	-0.7	0.8	1.5	-0.8
Heel T-Score	1.0	7.9	14.6	-1.1	2.1	2.2	3.8	3.8
BMI	2.0	11.4	19.1	-4.4	-3.6	3.7	-0.9	-3.2
Height	1.8	33.8	50.4	6.5	7.1	-5.3	3.2	6.1
Waist Hip Ratio (WHR)	0.9	4.2	6.9	-2.2	0.0	2.6	2.5	1.7
Systolic Blood Pressure	0.1	0.3	0.4	0.5	-0.6	0.1	-0.7	-0.4
Smoking Status	1.8	4.3	7.3	-2.2	-2.7	1.9	1.5	-1.8
Allergy or Eczema	1.0	2.7	8.6	-2.9	-1.0	1.8	0.7	-0.4
Cardiovascular Disease	0.3	1.0	3.9	-0.5	-0.8	0.2	-2.0	-0.4
Hypothyroidism (self reported)	0.5	1.1	4.2	0.3	-0.8	-0.0	-2.0	-0.7
Respiratory disease	0.2	0.5	1.0	-0.1	-0.9	0.6	-1.0	-0.7
Type 2 Diabetes (T2D) (2018)	1.0	1.8	4.1	-0.3	1.1	1.2	2.0	1.5
Lung FEV1/FVC ratio	0.1	0.7	1.7	-1.3	-0.9	-0.6	-0.6	-0.7
Lung FVC	1.3	6.8	13.2	2.9	3.6	-1.4	0.9	3.1
Neuroticism	0.3	0.8	2.0	0.1	1.4	0.6	0.4	1.3
Chronotype (morning person)	0.5	1.3	2.1	0.8	1.5	-1.4	0.5	1.2
Hair Pigment	0.0	0.5	0.9	-1.0	-0.4	-0.8	-0.6	-0.6
Tanning	0.0	0.2	0.4	-0.6	0.6	-0.6	0.1	0.0
Hand grip strength (left)	0.2	0.6	1.5	-0.8	-0.8	0.3	-1.2	-0.4
Number of treatments/medications taken	0.1	0.2	0.5	-0.1	-0.3	-0.7	-0.5	-0.5
Average weekly spirits intake	0.1	0.2	0.4	-0.3	0.3	0.0	0.4	0.6
Sensitivity / hurt feelings	1.8	3.0	5.1	2.0	2.3	-2.1	0.0	1.3
Frequency of depressed mood in last 2 weeks	1.1	1.6	3.1	0.9	1.5	0.7	1.2	1.8
Hearing difficulty/problems: Yes	0.5	0.7	1.7	0.6	1.3	-0.3	0.2	1.1
Relative age of first facial hair	1.6	3.2	6.5	0.2	-1.9	-1.5	-2.5	-1.9
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.6	0.7	0.1	-0.8	-0.4	-0.3
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.9	-0.9	0.5	0.1	-0.2	0.9
Ever had hysterectomy (womb removed)	0.5	0.6	1.3	-0.5	-0.7	-0.5	-1.2	-0.8
Systolic blood pressure, automated reading	0.3	0.9	2.5	-0.9	-0.9	1.6	-0.2	-0.4
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	1.3	-0.5	-0.5	0.7	-1.1	-0.1
Angina	0.5	0.7	2.3	0.5	0.9	-1.5	0.1	0.4
Medication for hormone replacement therapy	0.7	0.8	1.9	0.1	1.4	-0.4	1.0	1.1
Vitamin and mineral supplements	3.2	4.4	6.4	-2.5	-2.4	2.3	-0.1	-2.1
Supplements: Zinc	1.8	1.9	3.5	-0.1	1.8	-0.9	1.5	1.9
Medication: Co-codamol	1.7	1.9	5.2	-1.6	-0.0	1.2	2.3	0.5
Medication: Metformin	0.2	0.3	0.9	-0.0	-1.0	0.7	0.4	-0.4
Diabetes (father)	0.2	0.2	0.7	0.8	0.5	-0.4	0.4	0.2
Diabetes (mother)	0.1	0.1	0.2	0.2	0.1	-0.2	-0.4	-0.4
Severe depression (siblings)	2.9	3.2	7.7	0.9	2.8	-0.3	1.4	2.4
Pack years adult smoking proportion	0.9	1.3	2.6	-0.6	-1.5	1.6	0.1	-1.2
Impedance of leg (right)	1.3	6.5	10.0	2.4	3.2	-1.8	2.0	3.1
Leg fat-free mass (left)	0.0	0.1	0.3	0.4	-0.3	-0.1	-0.3	-0.5
Trunk fat percentage	0.2	0.7	1.8	-1.4	0.2	1.1	0.6	0.0
Hand grip strength (right)	0.5	1.5	5.4	0.4	-0.9	-0.7	-2.3	-0.8
Townsend deprivation index at recruitment	0.4	0.6	1.1	1.1	0.2	0.7	1.0	0.3
Current tobacco smoking	0.4	0.7	1.8	-0.2	-1.4	-0.2	-0.2	-1.2
Average weekly fortified wine intake	0.8	1.0	2.5	-1.6	-0.6	1.3	0.5	-0.2
Maternal smoking around birth	0.9	1.3	4.5	0.2	-1.1	2.1	-0.7	-0.7
Fed-up feelings	0.3	0.5	0.9	-0.7	0.6	0.9	-0.2	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	1.0	1.7	1.0	1.2	0.4	0.9	1.3
Relative age voice broke	0.7	1.1	3.3	0.1	-0.3	-1.4	-1.8	-0.6
Taking other prescription medications	0.5	0.7	1.2	-0.5	-0.9	-1.1	-0.3	-1.1
Age when periods started (menarche)	1.2	2.9	7.3	2.2	1.4	-2.7	0.1	0.7
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	1.6	-0.5	0.3	0.0	1.2	0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	2.0	-0.6	-0.7	0.6	1.4	0.2
Tinnitus: Yes, but not now, but have in the past	2.1	2.3	4.6	2.1	1.2	-2.2	0.6	0.6
Qualifications: CSEs or equivalent	0.4	0.6	1.3	-0.1	1.0	0.4	0.7	1.2
Serious illness, injury or assault to yourself	0.7	0.9	1.3	0.9	1.1	-0.1	1.1	1.0
High blood pressure	0.4	1.0	3.1	-1.1	-0.8	1.8	-0.4	0.1
Hayfever, allergic rhinitis or eczema	0.6	1.2	3.2	-1.8	-0.8	1.4	-0.1	-0.4
Multivitamins +/- minerals	1.2	1.6	2.6	1.3	1.6	-1.2	-0.1	1.5
Stomach or abdominal pain in last month	0.0	0.1	0.1	0.3	0.0	-0.2	0.2	-0.3
Supplements: Glucosamine	0.5	0.7	1.7	0.4	1.0	-0.2	-0.5	1.3
Diverticular disease/diverticulitis (self-reported)	1.7	2.0	4.1	-1.7	-1.3	2.0	-0.8	-0.8
Medication: Atenolol	0.3	0.4	1.0	-0.3	-0.4	1.0	0.8	-0.4
Medication: Levothyroxine sodium	0.3	0.6	1.2	-0.9	-0.7	0.6	-1.1	-0.2
Sitting height	1.8	12.6	23.0	4.8	4.1	-3.2	1.1	3.4
Chronic bronchitis/emphysema (father)	0.3	0.3	1.4	-0.5	0.2	0.0	1.2	0.2
High blood pressure (mother)	0.8	1.1	2.5	1.6	1.1	-0.4	0.5	1.2
Body mass index (BMI)	1.5	6.3	13.3	-3.6	-2.2	3.2	0.1	-1.7
Impedance of leg (left)	1.2	5.9	9.4	2.3	3.1	-1.8	1.7	3.0
Leg predicted mass (left)	0.0	0.1	0.3	0.5	-0.3	-0.0	-0.3	-0.5
Trunk fat mass	0.2	0.7	1.5	-1.2	0.2	1.1	0.8	0.1
Waist circumference	1.6	6.0	13.9	-3.7	-1.4	3.5	1.4	-0.4
Number of incorrect matches in round	0.4	0.6	1.2	1.0	0.6	-1.1	0.2	0.6
Past tobacco smoking	1.7	3.2	7.6	2.8	2.1	-1.4	-0.6	1.3
Alcohol usually taken with meals	1.5	2.4	4.8	-2.0	0.6	1.6	2.2	0.7
Nervous feelings	3.6	6.8	12.5	3.5	3.3	-2.4	-0.4	2.1
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.5	2.3	1.5	1.5	-1.1	0.3	1.2
Hearing difficulty/problems with background noise	0.2	0.3	0.9	1.0	0.4	-0.5	-0.4	0.4
Hair/balding pattern: Pattern 2	0.4	0.5	2.2	1.5	0.4	0.0	-0.0	0.2
Had menopause	0.1	0.1	0.5	-0.7	-0.1	-0.1	-0.3	0.0
Had other major operations	0.4	0.5	2.0	0.2	0.6	0.1	1.4	0.3
Forced vital capacity (FVC)	3.4	13.0	22.4	3.9	4.7	-2.4	1.7	4.3
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.9	-0.6	-1.0	0.0	0.1	-0.4
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.4	0.2	-0.5	-0.6	0.2	-0.2
Qualifications: None of the above	0.1	0.1	0.3	-0.3	0.2	0.5	-0.4	0.3
Financial difficulties in last 2 years	0.2	0.3	0.6	-0.3	0.5	0.3	0.8	0.5
Mouth/teeth dental problems	1.2	1.9	4.3	-0.2	-2.1	-0.7	-1.4	-1.5
Heart attack	0.2	0.2	0.7	0.6	-0.1	-0.3	0.8	-0.3
Allergy	0.3	0.7	2.0	1.4	0.3	-1.2	-0.4	0.0
Pain all over the body in last month	1.4	1.5	3.1	-0.3	-1.3	0.1	-1.8	-1.7
Diabetes (self-reported)	0.6	0.9	1.4	-0.8	0.6	0.9	1.2	1.0
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.9	-0.9	-0.2	0.5	0.8	0.1
Medication: Ramipril	1.0	1.3	2.6	-1.6	-1.1	1.5	0.1	-0.6
Medication: Simvastatin	2.2	3.2	8.8	-0.9	-1.8	-0.4	-3.0	-1.8
Fluid intelligence score	0.4	0.8	1.0	-0.8	0.8	1.0	0.9	1.0
Illnesses of siblings	0.8	1.1	3.5	0.1	-1.1	-0.4	-1.9	-0.8
Neuroticism score	0.9	1.9	4.7	0.6	2.2	0.3	0.8	1.9
Weight	0.1	0.6	1.4	-1.2	-0.2	1.1	0.7	-0.1
Impedance of arm (right)	2.2	10.2	17.8	3.9	3.4	-4.2	0.2	2.6
Arm fat percentage (right)	0.6	2.3	6.1	-2.5	-1.0	2.0	0.2	-0.8
Trunk fat-free mass	0.0	0.1	0.3	0.4	-0.1	0.6	0.3	0.1
Hip circumference	0.0	0.1	0.3	-0.5	0.0	-0.1	0.6	-0.3
Time employed in main current job	1.4	1.7	4.1	-0.8	2.0	-0.0	0.0	1.9
Alcohol intake versus 10 years previously	0.2	0.3	0.8	-0.3	-0.5	0.9	0.0	-0.5
Father’s age at death	0.3	0.4	0.8	0.9	0.5	-0.7	-0.6	0.2
Worrier / anxious feelings	0.7	1.4	3.1	0.8	1.8	0.1	0.5	1.7
Frequency of tiredness / lethargy in last 2 weeks	1.4	2.3	4.2	1.8	1.5	-2.0	-0.7	1.3
Falls in the last year	0.8	1.1	3.7	0.7	0.4	-1.9	-1.2	-0.2
Hair/balding pattern: Pattern 3	1.1	1.6	3.5	-1.4	0.5	1.2	1.9	0.8
Number of live births	1.7	2.5	4.6	1.9	2.1	-1.2	0.3	1.6
Forced expiratory volume in 1-second (FEV1)	2.9	9.7	16.2	3.4	4.0	-2.5	1.2	3.6
Pulse rate	0.6	1.1	2.7	1.0	1.6	0.3	0.4	1.2
Happiness	0.3	0.3	0.7	-0.8	0.0	0.8	0.0	0.4
Noisy workplace	1.3	1.5	3.0	0.3	1.5	-1.0	1.7	1.2
Qualifications: A levels/AS levels or equivalent	0.4	0.8	3.1	-1.8	-0.7	0.5	-0.2	-0.3
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.4	0.1	-0.5	-0.9	-0.8	-1.2
Mouth/teeth dental problems: Dentures	0.8	1.3	2.3	0.2	1.5	0.6	1.4	1.4
Asthma	0.3	0.6	0.8	-0.8	-0.9	0.5	-0.7	-0.8
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	1.8	-0.1	1.1	0.7	0.6	1.3
Medication: Cholesterol lowering	0.3	0.4	1.2	-0.5	-0.3	-0.7	-1.1	-0.4
Depression (self-reported)	1.3	1.6	5.2	2.3	0.8	-1.1	0.7	0.7
Medication: Lansoprazole	0.7	0.9	2.2	1.3	-0.3	-1.5	-0.6	-0.3
Prospective memory result	0.3	0.4	1.4	0.4	0.6	-1.2	-0.1	0.4
Lung cancer (father)	1.1	1.3	3.6	-1.9	-0.5	1.2	1.1	-0.0
Illnesses of mother	0.0	0.0	0.1	-0.1	-0.0	0.4	-0.1	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	2.8	9.1	13.9	3.7	3.7	-2.7	0.7	3.2
Pulse wave Arterial Stiffness index	0.8	0.9	2.2	-0.5	-0.8	0.8	-1.5	-0.9
Impedance of arm (left)	2.4	11.2	19.9	4.2	3.4	-4.5	0.3	2.5
Arm fat mass (right)	0.4	1.8	4.3	-2.1	-0.8	1.8	0.3	-0.6
Trunk predicted mass	0.0	0.2	0.5	0.3	-0.2	0.7	0.4	0.1
Standing height	1.7	16.9	28.2	5.3	4.4	-4.6	1.2	3.8
Length of working week for main job	1.6	1.8	4.1	-1.2	-1.6	-0.0	-1.0	-2.0
Exposure to tobacco smoke at home	0.3	0.3	1.0	-0.3	0.5	-0.3	0.1	1.0
Breastfed as a baby	0.3	0.4	1.2	1.1	0.4	0.1	0.6	0.4
Tense / ‘highly strung’	0.3	0.5	1.1	-0.8	1.0	0.5	0.2	0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	3.3	-0.7	1.0	1.4	0.6	1.8
Hair/balding pattern: Pattern 4	0.6	1.4	2.8	-0.5	1.7	0.4	1.1	1.6
Birth weight of first child	3.3	6.0	13.4	1.9	3.7	-1.0	2.0	2.9
Peak expiratory flow (PEF)	0.5	1.2	2.2	1.5	0.7	-1.5	-0.9	0.5
Pulse wave reflection index	1.4	1.8	3.5	-1.3	-1.9	0.7	-1.2	-1.4
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.1	-1.0	0.1	0.4	0.8	0.2
Loud music exposure frequency	2.1	2.3	4.3	1.5	1.8	-1.1	0.8	2.1
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	1.7	0.1	1.2	-0.4	0.8	1.3
Mouth/teeth dental problems: Bleeding gums	2.7	3.5	8.1	0.0	2.8	-0.7	2.1	2.1
Blood clot in the leg (DVT)	0.3	0.4	1.7	-1.3	0.0	0.2	0.5	0.1
Medication: Paracetamol	0.1	0.2	0.6	0.0	0.5	-0.8	0.1	0.4
Headache pain in last month	0.4	0.7	1.9	0.8	-0.5	-0.2	-1.4	-0.9
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	1.6	1.3	1.0	-0.5	1.0	1.0
Glaucoma (self-reported)	0.3	0.3	1.1	0.4	0.3	-0.0	1.0	0.5
Gout (self-reported)	2.2	3.0	4.4	-2.0	-2.0	2.1	-0.1	-1.7
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	1.6	0.1	-0.2	-0.1	-1.3	-0.2
Medication: Amlodipine	0.1	0.2	0.4	0.3	0.7	0.3	0.0	0.6
Medication: Ventolin 100micrograms inhaler	0.5	0.7	2.4	-0.7	-0.5	-0.2	-1.6	-0.0
Birth weight	0.4	0.8	1.9	1.4	1.0	-0.6	0.5	0.8
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.4	1.1	1.2	-0.2	0.4	0.7
High blood pressure (siblings)	1.1	1.6	4.5	0.3	1.4	0.6	2.1	1.1
Forced vital capacity (FVC), Best measure	3.6	13.2	21.7	4.5	4.7	-2.8	0.9	4.0
Body fat percentage	0.5	2.1	5.4	-2.3	-0.5	2.0	0.8	-0.4
Leg fat percentage (right)	1.1	4.1	9.3	-3.0	-0.7	3.0	1.3	-0.4
Arm fat-free mass (right)	0.1	0.4	1.7	-0.3	-0.4	1.3	0.3	-0.3
Exposure to tobacco smoke outside home	0.4	0.5	1.1	1.1	-0.0	-0.7	-0.9	-0.2
Comparative body size at age 10	1.3	3.5	8.1	-2.9	-1.1	2.3	1.6	-0.5
Number of full brothers	1.3	1.6	4.0	2.0	1.7	-0.1	-0.3	1.0
Worry too long after embarrassment	0.9	1.5	3.3	1.1	1.8	-0.6	0.6	1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	1.1	1.1	0.5	1.0	1.0	0.9
Wheeze or whistling in the chest in last year	0.0	0.1	0.1	0.2	0.4	0.0	-0.4	0.3
Number of children fathered	0.0	0.0	0.2	-0.0	0.1	0.4	-0.2	-0.0
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.3	-0.1	0.7	0.3	1.0	1.1
Age at first live birth	0.6	1.1	2.1	-1.5	-1.1	-0.9	-0.9	-0.9
Pulse wave peak to peak time	1.4	1.6	2.4	1.0	1.2	-1.3	1.5	1.2
Health satisfaction	0.9	1.2	2.8	0.5	-0.8	-0.8	-1.7	-1.2
Shortness of breath walking on level ground	2.2	2.6	5.7	2.4	1.6	-1.8	0.6	1.2
Qualifications: College or University degree	1.4	4.4	7.7	-2.8	-2.7	1.1	-1.3	-2.1
Eye problems/disorders: None of the above	1.8	2.1	5.4	2.3	0.8	-2.0	-0.1	0.4
Mouth/teeth dental problems: Loose teeth	1.3	1.5	3.6	-1.4	-0.1	1.9	1.5	0.0
Emphysema/chronic bronchitis	0.3	0.3	0.7	-0.0	0.7	-0.6	-0.3	0.8
Medication for pain relief, constipation, heartburn	0.1	0.2	0.3	-0.2	-0.6	-0.1	0.4	-0.5
Neck or shoulder pain in last month	1.4	2.0	4.3	1.2	2.1	-0.5	0.7	1.8
Medication: Blood pressure	2.5	4.5	8.8	-3.0	-2.2	2.3	-0.3	-1.8
Angina (self-reported)	0.9	1.1	2.7	0.8	1.2	-1.6	0.4	0.7
Migraine (self-reported)	0.8	1.0	1.5	1.2	0.9	-0.9	-1.0	0.9
Medication: Ibuprofen	1.8	2.1	3.5	-0.8	1.4	1.2	1.9	1.8
Medication: Allopurinol	3.4	4.6	7.0	-2.6	-2.4	2.0	-0.7	-2.4
Medication: Omeprazole	0.8	1.0	3.0	1.7	0.6	-1.1	-0.5	-0.1
Medication: Seretide 50 evohaler	0.5	0.5	1.4	0.5	1.0	0.1	0.2	1.2
Mean time to correctly identify matches	0.2	0.4	0.9	0.9	0.1	0.4	-0.9	-0.1
Heart disease (mother)	0.5	0.7	1.4	0.6	1.0	-0.0	1.2	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	1.9	-1.1	-1.4	0.2	-0.9	-1.4
Whole body fat mass	0.3	1.3	3.1	-1.8	-0.4	1.6	0.8	-0.3
Leg fat mass (right)	0.7	2.6	6.2	-2.5	-0.8	2.2	0.9	-0.5
Arm predicted mass (right)	0.1	0.6	2.2	-0.5	-0.4	1.5	0.3	-0.3
Pulse rate, automated reading	2.2	7.2	12.8	2.5	3.6	-0.5	2.5	3.2
Alcohol intake frequency.	0.2	0.5	1.9	1.4	0.7	-0.3	0.3	0.1
Comparative height size at age 10	0.8	4.6	6.9	2.1	2.6	-2.0	1.1	2.5
Number of full sisters	3.1	3.7	9.1	3.0	2.0	-0.9	1.4	1.7
Suffer from ‘nerves’	1.5	2.4	6.0	1.4	2.4	-0.4	0.2	2.0
Overall health rating	0.4	0.8	1.7	1.2	1.0	-1.3	-0.0	0.4
Chest pain or discomfort	0.6	0.8	1.7	1.0	1.3	-1.1	0.2	0.5
Had major operations	0.2	0.2	0.8	0.4	-0.3	-0.9	-0.4	-0.0
Age at last live birth	0.4	0.5	1.3	-0.8	0.4	-1.1	-0.2	0.7
Family relationship satisfaction	0.1	0.1	0.3	0.4	0.2	-0.3	-0.5	0.3
Leg pain on walking	0.5	0.6	1.3	1.0	-0.0	-1.1	-0.7	-0.1
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	2.3	-0.3	1.2	-0.3	1.5	1.5
Commuting to job workplace: Car/motor vehicle	0.3	0.4	0.6	0.3	-0.7	-0.7	-0.4	-0.8
Illness, injury, bereavement, stress in last 2 years	0.4	0.4	1.9	0.0	-0.4	-1.4	0.2	-0.1
Medication: Aspirin	0.8	1.1	2.9	0.3	1.6	0.1	0.1	1.7
Supplements: Vitamin C	1.9	2.2	4.0	0.9	1.8	-2.0	0.4	1.7
Knee pain experienced in last month	1.3	2.0	3.3	1.8	1.6	-1.7	-0.3	1.0
Hypertension (Self-reported)	0.7	1.8	4.4	-1.7	-1.1	2.1	-0.6	-0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.4	0.5	-0.4	-0.0	0.1	-0.7
Illnesses of father: Heart disease	2.2	3.0	5.5	1.6	1.9	-2.3	0.9	1.7
Illnesses of siblings: Diabetes	0.1	0.2	0.3	-0.2	-0.5	0.5	0.2	-0.6
Smoking status: Previous	1.3	1.9	5.3	-2.3	-0.9	1.4	1.3	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	1.3	2.8	4.6	2.1	1.8	-1.7	1.0	1.4
Whole body fat-free mass	0.0	0.1	0.2	0.3	-0.3	0.5	0.0	-0.3
Leg fat-free mass (right)	0.0	0.2	0.4	0.4	-0.5	-0.1	-0.6	-0.7
Arm fat percentage (left)	0.6	2.4	5.8	-2.4	-1.2	1.9	0.2	-1.1
Average weekly red wine intake	3.3	4.8	12.7	-3.6	-0.9	2.9	1.4	-0.2
Handedness (chirality/laterality): Left-handed	2.5	3.0	8.3	-2.9	-1.9	1.5	0.4	-0.8
Mood swings	0.1	0.3	0.8	0.9	0.6	-0.4	-0.1	0.2
Loneliness, isolation	1.7	2.4	4.6	1.5	2.0	0.1	1.0	2.1
Long-standing illness, disability or infirmity	0.8	1.3	2.9	1.5	0.7	-1.7	0.1	0.8
Ever had bowel cancer screening	0.8	0.9	2.3	-1.5	-0.8	0.6	-0.7	-0.8
Diabetes diagnosed by doctor	0.9	1.5	4.2	-0.5	0.8	0.9	2.0	1.3
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.5	-0.2	-0.6	-0.7	0.2	-0.7
Friendships satisfaction	0.3	0.3	0.5	0.7	0.6	-0.3	-0.5	0.7
Qualifications: nursing, teaching	1.5	2.3	6.5	-0.0	-1.0	-1.2	-2.5	-1.5
Commuting to job workplace: Walk	0.5	0.6	1.4	1.2	0.8	-0.8	-0.3	0.3
Eye problems/disorders: Cataract	2.2	2.5	5.9	-2.4	-1.2	2.1	0.3	-0.9
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.7	0.8	-0.2	-0.6	-0.7	-0.4
Medication for cholesterol	0.2	0.3	0.6	0.5	0.6	-0.8	0.2	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	1.2	-0.4	-0.2	0.2	-1.1	0.0
Back pain experienced in last month	1.6	2.3	4.9	0.2	2.2	0.1	1.5	2.1
Mineral and other dietary supplements	0.3	0.5	2.0	-0.2	-0.1	-0.5	1.4	-0.1
Breast cancer (self-reported)	0.8	1.0	2.2	-0.8	-1.0	-0.0	-1.0	-1.5
Asthma (self-reported)	0.5	0.9	1.5	-0.9	-1.2	0.5	-0.9	-1.1
Osteoporosis (self-reported)	0.1	0.1	0.2	0.2	-0.1	-0.5	0.2	-0.4
Osteoarthritis (self-reported)	0.7	0.9	2.6	-1.6	-0.7	-0.5	0.4	-1.0
Medication: Aspirin	0.6	0.8	1.9	0.4	1.2	0.5	0.4	1.4
Medication: Gliclazide	0.4	0.4	1.3	0.2	0.8	0.0	0.2	1.1
Illnesses of father: None of the above (group 1)	0.2	0.2	0.6	0.1	-0.4	0.8	-0.6	-0.1
Smoking status: Current	0.8	1.3	3.3	-0.5	-1.8	-0.1	-0.5	-1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	2.8	1.7	0.9	-0.8	-0.1	0.9
Whole body water mass	0.0	0.1	0.3	0.1	-0.4	0.6	-0.0	-0.4
Leg predicted mass (right)	0.1	0.3	0.5	0.5	-0.5	-0.1	-0.6	-0.7
Arm fat mass (left)	0.4	1.7	3.8	-1.9	-1.0	1.7	0.0	-0.9
Number of self-reported non-cancer illnesses	0.1	0.3	0.6	-0.3	-0.5	-0.8	-0.4	-0.5
Average weekly champagne plus white wine intake	1.0	1.4	3.5	-1.9	-1.6	0.5	-0.4	-0.7
Miserableness	0.1	0.2	0.5	0.0	0.7	-0.2	-0.3	0.4
Guilty feelings	0.5	0.8	2.2	-0.0	1.1	0.8	0.4	1.5
Wears glasses or contact lenses	1.3	1.4	3.4	-0.5	0.7	1.8	1.5	1.0
Ever taken oral contraceptive pill	0.4	0.5	1.1	-1.1	-0.5	-0.9	0.1	-0.1
Hearing aid user	0.2	0.2	0.8	-0.0	0.2	0.9	-0.2	0.1
Mother’s age at death	0.3	0.4	1.3	-0.4	-0.1	-1.1	-0.7	-0.4
Financial situation satisfaction	0.5	0.6	1.4	0.7	-0.1	-1.2	-1.0	-0.2
Tinnitus: Yes, now most or all of the time	0.8	0.9	1.5	0.7	1.2	0.7	0.8	1.1
Commuting to job workplace: Public transport	0.2	0.3	0.8	-0.9	-0.3	0.6	0.3	0.0
Eye problems/disorders: Glaucoma	0.3	0.3	0.9	0.5	0.4	-0.5	0.9	0.3
Medication: Blood pressure	0.7	1.3	2.2	-1.0	-1.4	1.5	-0.5	-1.1
Pain type(s) experienced in last month: Hip pain	1.8	2.2	6.7	2.6	1.2	-1.6	0.1	0.5
Supplements: Fish oil (including cod liver oil)	1.5	2.0	5.6	-0.5	-1.0	1.4	-2.4	-1.1
High cholesterol (Self-reported)	1.5	2.7	8.3	0.1	-0.9	-1.9	-2.9	-0.9
Medication: Bendroflumethiazide	0.2	0.2	0.8	-0.9	-0.4	0.0	0.4	0.0
Medication: Paracetamol	0.4	0.6	0.9	-0.0	1.0	-0.7	0.9	0.9
Medication: Lisinopril	1.9	2.5	6.5	-2.0	-1.3	2.5	0.3	-0.6
Medication: Atorvastatin	0.2	0.2	0.8	-0.1	-0.2	-0.9	-0.2	-0.4
Illnesses of father: High blood pressure	0.7	0.9	1.5	-0.2	1.2	-0.0	1.2	1.2
Alcohol drinker status: Never	0.4	0.5	2.0	-0.6	0.1	-1.4	-0.3	0.2
Ever smoked	1.6	2.8	6.0	-2.5	-2.2	1.3	0.3	-1.3
Basal metabolic rate	0.0	0.1	0.2	0.1	-0.2	0.5	0.2	-0.2
Leg fat percentage (left)	1.1	4.1	9.8	-3.1	-0.8	3.0	1.1	-0.5
Arm fat-free mass (left)	0.1	0.4	1.2	-0.5	-0.5	1.1	0.0	-0.4
Number of operations (self-reported)	0.3	0.4	1.2	0.4	0.3	-1.1	0.6	0.3
Average weekly beer plus cider intake	0.0	0.1	0.1	0.2	0.1	0.1	-0.4	0.3
Irritability	0.3	0.6	1.5	1.2	0.5	-0.9	0.6	-0.0
Risk taking	0.2	0.3	0.9	0.4	-0.6	-0.4	-0.2	-1.0
Ever had prostate specific antigen (PSA) test	1.0	1.2	3.2	1.5	0.1	-1.8	-0.5	-0.2
Fractured/broken bones in last 5 years	0.2	0.2	0.4	-0.2	0.5	-0.3	0.5	0.7
Age started oral contraceptive pill	1.0	1.3	2.0	-1.1	-1.1	0.4	-1.4	-1.4
Diastolic blood pressure, automated reading	0.7	2.3	5.0	-1.6	0.1	2.2	1.6	1.1
Ever depressed for a whole week	0.1	0.1	0.5	-0.7	-0.0	-0.2	-0.3	0.4
Unable to work because of sickness or disability	1.1	1.4	2.6	1.5	1.1	-1.6	-0.7	0.5
Commuting to job workplace: Cycle	0.2	0.2	0.8	-0.6	-0.9	-0.0	0.0	0.0
Myopia	1.8	2.7	5.9	0.2	2.4	0.5	1.4	2.3
Vascular/heart problems diagnosed by doctor	0.2	0.4	1.5	0.5	0.4	-1.2	0.4	-0.1
Cholesterol lowering medication	1.1	1.6	3.2	-1.3	-1.4	0.4	-1.8	-1.0
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	2.8	1.7	0.2	-1.1	-0.9	-0.5
Pain experienced in last month	2.8	4.6	8.9	-1.8	-3.0	1.9	-1.2	-2.3
Supplements: Calcium	0.2	0.3	1.2	-1.1	-0.1	-0.3	-0.0	-0.3
Basal cell carcinoma (self-reported)	0.6	0.7	1.9	-0.3	1.4	-0.2	0.5	1.2
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.4	0.5	-0.4	-0.2	0.6	-0.6
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	2.6	-1.6	-0.0	0.4	0.6	0.2
Heart disease (siblings)	0.3	0.4	0.8	-0.6	-0.6	0.6	-0.4	-0.9
Alcohol drinker status: Previous	0.6	0.7	1.6	-0.1	0.3	1.3	1.0	0.7
Pack years of smoking	1.0	1.5	3.2	-0.7	-1.5	1.8	0.2	-1.2
Impedance of whole body	2.1	10.9	15.8	4.0	3.8	-3.5	1.1	3.2
Leg fat mass (left)	0.7	2.7	6.6	-2.6	-0.9	2.3	0.8	-0.6
Arm predicted mass (left)	0.1	0.4	1.5	-0.4	-0.5	1.2	0.0	-0.4