Hub : Genes

ACTG1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0670	0.0260	0.00180	0.056	0.028	0.047	0.055	0.052	2.3e-07	1.9e-04	1.8e-06	3.0e-07	6.2e-07
2	GTEx	Esophagus Muscularis	0.1510	0.0600	0.00570	0.005	NA	0.014	NA	0.005	1.6e-01	NA	4.5e-02	NA	1.6e-01
3	NTR	Blood	0.0351	0.0126	0.00022	0.002	0.016	0.011	0.015	0.003	4.4e-02	4.2e-06	1.7e-04	6.7e-06	2.6e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.5	0.8	2.4	-0.1	-0.2	-1.5
Bipolar Disorder or Schizophrenia	1.6	3.8	6.7	-0.5	-2.1	-2.6
Depressed Affect (Nagel 2018)	2.3	4.8	11.4	-0.7	1.6	-3.4
Depression (Nagel 2018)	1.3	2.0	4.1	1.4	-0.2	-2.0
Intelligence (Savage-Jansen 2018)	1.5	4.5	8.1	-2.3	0.4	-2.8
Neuroticism (Nagel 2018)	2.9	6.8	20.2	-0.2	0.2	-4.5
Schizophrenia (2018)	1.8	3.8	7.3	-0.5	-2.7	-2.0
Schizophrenia vs Biploar Disorder	0.1	0.1	0.2	0.0	0.0	-0.5
Worry (Nagel 2018)	2.1	4.5	12.5	0.2	-0.9	-3.5
Alzheimer’s Disease (in mother)	0.7	0.8	2.0	0.3	-0.5	-1.4
Alzheimer’s Disease (in father)	1.5	1.6	1.7	-1.3	1.2	1.3
Alzheimer’s Disease (including proxy)	0.0	0.0	0.1	-0.1	0.3	0.1
Crohns Disease (2017)	1.5	3.3	6.8	-0.6	2.6	1.7
Irritable Bowel Disease (IBD)	3.2	7.5	12.4	-1.4	2.9	3.5
Ulcerative Colitis (UC)	3.8	7.1	16.4	-1.3	1.8	4.0
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	0.3	0.6	1.0	-0.7	1.0	-0.5
Verbal and Numeric Reasoning (VNR)	1.3	3.2	8.4	-1.0	-0.2	-2.9
Breast Cancer	1.0	2.3	4.5	2.1	-0.5	-1.5
Ovarian Cancer	0.1	0.1	0.3	0.5	-0.0	-0.0
Prostate Cancer	1.9	2.7	5.1	1.6	-0.8	-2.2
Age at First Birth	0.1	0.1	0.3	-0.2	-0.5	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	1.8	2.4	3.8	0.2	-2.0	1.9
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.2	0.4	1.2	-1.1	0.0	0.0
Mean Putamen Volume	1.4	1.7	3.5	-1.2	-1.9	0.2
Fasting Glucose	1.6	1.9	4.4	0.9	0.7	2.1
HbA1C	1.1	1.3	3.2	-0.8	-0.1	1.8
HDL Cholesterol	0.4	0.7	1.8	0.0	1.4	-0.6
LDL Cholesterol	0.2	0.4	1.0	-0.3	-0.4	1.0
Lupus	0.5	0.8	1.4	1.0	-1.2	0.3
Neuroticism (2016)	1.7	2.5	7.2	-0.4	0.1	-2.7
Primary Biliary Cirrhosis	1.9	2.7	6.8	-0.6	0.9	2.6
Rheumatoid Arthritis	0.7	0.9	2.5	-0.4	0.1	-1.6
Schizophrenia (2014)	1.3	2.9	5.4	-0.4	-2.3	-1.8
Triglycerides	0.5	0.9	1.2	0.6	-1.1	1.1
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0
Ulcerative Colitis	1.1	1.6	2.9	-1.2	0.5	1.7
Blood Eosinophil Count	0.1	0.5	1.2	1.1	-0.2	-0.4
Blood Platelet Count	0.0	0.6	0.8	0.7	0.6	0.9
Blood Red Count	1.3	12.1	18.7	0.2	4.3	4.2
Blood White Count	0.3	2.6	3.9	-2.0	2.0	0.1
Heel T-Score	0.7	5.9	13.8	-0.1	-2.0	-3.7
BMI	0.8	4.4	11.2	3.3	-1.4	-0.3
Height	1.0	18.8	47.3	2.5	1.7	6.9
Waist Hip Ratio (WHR)	0.8	3.7	7.2	-2.0	2.7	0.3
Systolic Blood Pressure	0.7	3.7	5.8	-2.3	-0.0	2.4
Smoking Status	0.1	0.2	0.5	-0.3	0.7	-0.2
Allergy or Eczema	0.1	0.4	1.0	1.0	0.3	-0.4
Cardiovascular Disease	1.9	6.1	10.4	-3.2	1.8	2.1
Hypothyroidism (self reported)	0.3	0.6	1.7	-1.3	-0.2	0.1
Respiratory disease	0.9	2.0	2.6	1.4	-1.6	-1.2
Type 2 Diabetes (T2D) (2018)	2.6	4.9	8.9	0.4	3.0	2.4
Lung FEV1/FVC ratio	3.3	16.7	22.9	-2.1	4.8	4.8
Lung FVC	2.8	14.5	27.0	2.1	-3.4	-5.2
Neuroticism	3.3	8.0	23.3	-0.2	0.8	-4.8
Chronotype (morning person)	0.5	1.2	2.1	0.1	1.5	-1.1
Hair Pigment	3.6	102.7	225.0	-8.3	3.9	15.0
Tanning	1.1	13.1	25.7	3.6	-0.9	-5.1
Hand grip strength (left)	1.5	3.9	7.7	2.8	-1.5	-1.3
Number of treatments/medications taken	2.3	4.1	6.9	-2.1	1.0	2.6
Average weekly spirits intake	0.4	0.5	0.8	-0.9	0.7	0.3
Sensitivity / hurt feelings	0.6	1.1	2.6	0.8	0.1	-1.6
Frequency of depressed mood in last 2 weeks	1.6	2.2	2.3	1.5	-1.5	-1.4
Hearing difficulty/problems: Yes	1.2	1.8	3.9	-2.0	0.1	-1.2
Relative age of first facial hair	2.3	4.8	12.7	3.6	-1.1	0.6
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.3	-0.7	-1.1	-0.5
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.1	-1.1	-0.0	0.6
Ever had hysterectomy (womb removed)	0.6	0.6	0.9	-0.6	1.0	-0.8
Systolic blood pressure, automated reading	0.2	0.7	1.0	-1.0	-1.0	0.4
Eye problems/disorders: Diabetes related eye disease	1.2	1.3	3.8	-0.1	1.9	0.4
Angina	1.0	1.3	2.4	-0.2	1.6	1.2
Medication for hormone replacement therapy	1.1	1.2	2.0	0.9	-1.4	1.0
Vitamin and mineral supplements	0.5	0.7	1.5	-0.3	1.2	0.7
Supplements: Zinc	1.4	1.5	2.8	-0.5	1.2	1.7
Medication: Co-codamol	0.3	0.4	0.4	-0.6	-0.5	-0.6
Medication: Metformin	3.7	5.2	9.9	-0.4	2.4	3.1
Diabetes (father)	1.7	2.1	3.4	-0.8	1.5	1.8
Diabetes (mother)	0.3	0.4	0.8	-0.5	0.9	-0.1
Severe depression (siblings)	0.7	0.8	1.5	0.8	-0.7	-1.2
Pack years adult smoking proportion	0.2	0.3	0.4	0.5	-0.7	-0.5
Impedance of leg (right)	0.9	4.2	9.6	-1.2	1.2	-3.1
Leg fat-free mass (left)	1.6	8.4	22.2	1.7	-0.3	4.7
Trunk fat percentage	1.2	4.9	7.5	-0.1	2.7	2.7
Hand grip strength (right)	1.4	3.8	5.5	2.2	-2.4	-1.0
Townsend deprivation index at recruitment	0.1	0.2	0.4	0.2	0.4	0.6
Current tobacco smoking	0.3	0.5	0.8	0.6	-0.4	-0.9
Average weekly fortified wine intake	0.4	0.5	1.0	1.0	-0.4	0.5
Maternal smoking around birth	1.1	1.5	3.9	0.5	0.7	2.0
Fed-up feelings	1.1	2.0	3.5	-0.5	1.9	-1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	2.0	2.6	2.9	1.7	-1.6	-1.6
Relative age voice broke	2.2	3.4	5.8	2.4	-1.8	-0.9
Taking other prescription medications	0.8	1.2	2.8	-1.7	0.4	0.8
Age when periods started (menarche)	2.5	5.9	8.2	2.9	-2.5	-1.8
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	2.0	0.1	0.1	-1.4
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	0.9	-0.9	-0.7	-0.0
Tinnitus: Yes, but not now, but have in the past	0.4	0.5	1.1	-0.5	-1.0	-0.2
Qualifications: CSEs or equivalent	0.6	0.8	1.6	0.7	-1.2	0.5
Serious illness, injury or assault to yourself	0.4	0.5	1.3	0.3	0.3	1.1
High blood pressure	1.2	3.5	7.0	-2.6	0.9	1.6
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.5	0.7	-0.2	-0.7
Multivitamins +/- minerals	0.1	0.1	0.1	0.3	-0.1	0.4
Stomach or abdominal pain in last month	1.0	1.2	2.9	0.7	-1.7	-0.5
Supplements: Glucosamine	2.5	3.3	5.3	-1.4	1.6	2.3
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	1.1	1.1	0.7	0.9
Medication: Atenolol	2.2	2.7	6.8	-0.2	1.1	2.6
Medication: Levothyroxine sodium	1.3	2.2	5.0	-2.2	0.9	0.9
Sitting height	1.0	6.9	17.6	1.7	-0.1	4.2
Chronic bronchitis/emphysema (father)	0.9	1.0	2.1	-1.0	1.4	-0.2
High blood pressure (mother)	0.3	0.4	0.5	-0.6	0.6	-0.7
Body mass index (BMI)	0.4	1.7	3.0	1.7	-0.4	1.3
Impedance of leg (left)	0.8	3.7	5.7	-1.6	1.6	-2.4
Leg predicted mass (left)	1.5	8.0	21.5	1.6	-0.4	4.6
Trunk fat mass	1.2	5.1	11.4	0.6	1.9	3.4
Waist circumference	0.5	1.9	3.3	0.7	1.4	1.8
Number of incorrect matches in round	0.5	0.8	2.4	-0.1	-1.5	-0.4
Past tobacco smoking	0.0	0.1	0.2	-0.4	0.1	0.3
Alcohol usually taken with meals	2.3	3.7	5.4	-2.2	2.3	0.8
Nervous feelings	0.7	1.3	2.6	0.1	-1.6	-1.0
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	0.9	-0.0	-1.0	-0.7
Hearing difficulty/problems with background noise	0.6	1.0	2.3	-0.3	0.8	-1.5
Hair/balding pattern: Pattern 2	1.5	1.9	3.4	0.4	1.8	1.4
Had menopause	0.3	0.4	1.1	-0.3	-1.0	0.1
Had other major operations	1.6	1.9	3.7	-0.9	1.1	1.9
Forced vital capacity (FVC)	1.0	4.0	6.1	2.5	-1.9	-1.5
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.4	-0.3	-0.3	-0.6
Ever unenthusiastic/disinterested for a whole week	2.0	2.5	6.2	-0.6	-1.0	-2.5
Qualifications: None of the above	0.2	0.4	1.1	1.1	-0.2	-0.4
Financial difficulties in last 2 years	0.9	1.2	2.9	1.7	0.2	0.8
Mouth/teeth dental problems	0.2	0.4	0.5	-0.3	-0.7	0.7
Heart attack	0.4	0.5	1.0	1.0	-0.1	-0.7
Allergy	1.0	2.3	2.7	-1.6	1.6	1.3
Pain all over the body in last month	0.6	0.7	1.4	-0.1	0.8	1.2
Diabetes (self-reported)	2.1	3.3	5.5	-0.5	2.4	2.0
Hayfever/allergic rhinitis (self-reported)	1.2	1.6	4.3	-2.1	0.6	0.3
Medication: Ramipril	0.9	1.2	3.1	-1.8	0.2	0.7
Medication: Simvastatin	0.6	0.8	2.1	-0.6	1.4	-0.3
Fluid intelligence score	1.3	2.7	8.0	-0.3	0.3	-2.8
Illnesses of siblings	0.9	1.3	3.2	-0.0	-0.8	-1.8
Neuroticism score	2.0	4.1	11.8	0.5	-0.6	-3.4
Weight	1.2	5.7	13.2	1.9	0.6	3.6
Impedance of arm (right)	2.7	12.7	20.8	-4.0	4.6	1.1
Arm fat percentage (right)	0.8	3.2	4.8	0.0	2.2	2.2
Trunk fat-free mass	1.3	7.7	13.5	2.7	-1.5	3.7
Hip circumference	0.8	3.6	7.2	1.6	1.0	2.7
Time employed in main current job	0.2	0.3	0.6	-0.3	-0.4	-0.8
Alcohol intake versus 10 years previously	0.2	0.3	0.6	-0.7	-0.2	0.5
Father’s age at death	0.3	0.4	1.0	0.1	1.0	-0.3
Worrier / anxious feelings	0.3	0.5	0.9	0.6	0.3	-1.0
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.2	0.5	0.3	-0.4
Falls in the last year	0.5	0.7	1.4	-1.2	-0.4	0.7
Hair/balding pattern: Pattern 3	0.2	0.3	0.7	-0.4	0.4	-0.8
Number of live births	5.5	7.8	9.8	2.7	-3.1	-2.5
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	1.3	1.1	-0.5	-0.8
Pulse rate	0.7	1.2	1.5	1.2	-1.2	-0.9
Happiness	1.3	1.6	2.0	0.9	-1.4	-1.4
Noisy workplace	1.2	1.5	4.1	0.1	0.5	2.0
Qualifications: A levels/AS levels or equivalent	1.4	3.1	4.6	-1.8	1.2	-2.1
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	0.7	0.9	0.7	0.5
Mouth/teeth dental problems: Dentures	1.1	1.8	5.2	0.5	-0.4	-2.3
Asthma	0.4	0.9	2.2	0.6	-1.5	0.3
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	2.2	-0.1	1.5	1.4
Medication: Cholesterol lowering	1.5	2.3	4.9	-0.7	2.2	1.2
Depression (self-reported)	1.5	1.8	4.6	0.3	-0.8	-2.1
Medication: Lansoprazole	0.3	0.3	0.6	-0.8	0.3	0.6
Prospective memory result	1.6	2.0	5.0	-0.7	0.7	2.2
Lung cancer (father)	1.2	1.4	2.9	0.3	1.7	1.1
Illnesses of mother	0.2	0.2	0.4	-0.3	-0.4	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	0.7	0.6	-0.5	-0.9
Pulse wave Arterial Stiffness index	1.4	1.6	2.7	-1.1	0.9	1.6
Impedance of arm (left)	2.7	12.5	22.4	-3.6	4.7	1.4
Arm fat mass (right)	0.8	3.3	7.4	1.0	1.3	2.7
Trunk predicted mass	1.4	7.8	13.4	2.7	-1.6	3.7
Standing height	1.3	12.4	32.1	0.3	2.2	5.7
Length of working week for main job	0.7	0.8	2.0	-1.4	-0.6	-0.1
Exposure to tobacco smoke at home	0.4	0.4	0.7	0.6	-0.5	0.8
Breastfed as a baby	1.8	2.2	6.0	-0.1	-0.7	-2.4
Tense / ‘highly strung’	1.6	2.6	6.7	-0.8	-0.6	-2.6
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.8	3.8	-0.1	1.2	-1.9
Hair/balding pattern: Pattern 4	1.2	2.9	8.5	-0.1	0.6	-2.9
Birth weight of first child	0.4	0.7	1.1	-0.9	-1.0	-0.5
Peak expiratory flow (PEF)	0.1	0.2	0.6	0.8	0.3	-0.1
Pulse wave reflection index	2.8	3.4	4.6	-1.6	1.8	2.1
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.3	-0.7	-1.2	-0.5
Loud music exposure frequency	0.1	0.1	0.1	0.4	0.3	0.1
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	2.4	-1.5	1.2	-0.5
Mouth/teeth dental problems: Bleeding gums	1.4	1.8	3.7	-0.5	1.2	1.9
Blood clot in the leg (DVT)	0.7	0.9	2.6	-0.3	-0.3	-1.6
Medication: Paracetamol	1.3	2.1	2.7	-1.4	1.6	1.4
Headache pain in last month	1.3	2.1	5.3	-2.3	1.1	-0.0
Medication for cholesterol, blood pressure or diabetes	2.0	3.3	5.4	2.3	-2.0	-0.8
Glaucoma (self-reported)	0.1	0.2	0.4	-0.6	0.3	0.2
Gout (self-reported)	0.3	0.4	1.0	1.0	-0.3	-0.4
Hypothyroidism/myxoedema (self-reported)	0.4	0.9	2.5	-1.6	-0.1	0.3
Medication: Amlodipine	0.7	1.0	2.5	-0.1	-0.7	-1.6
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.1	0.1	-0.3	1.0
Birth weight	0.4	0.8	2.0	-0.1	-1.4	0.6
Chronic bronchitis/emphysema (mother)	1.6	1.9	2.1	1.4	-1.3	-1.4
High blood pressure (siblings)	0.8	1.2	1.9	0.5	1.2	1.4
Forced vital capacity (FVC), Best measure	0.7	2.6	3.5	1.6	-1.9	-1.3
Body fat percentage	0.6	2.5	3.7	0.5	1.9	1.9
Leg fat percentage (right)	0.3	0.9	2.7	1.6	0.3	-0.1
Arm fat-free mass (right)	1.4	7.2	8.9	2.9	-2.1	3.0
Exposure to tobacco smoke outside home	0.3	0.4	0.8	0.9	0.0	0.7
Comparative body size at age 10	1.5	4.1	6.1	1.6	-2.5	-1.9
Number of full brothers	0.3	0.4	1.0	0.1	0.3	1.0
Worry too long after embarrassment	1.1	1.8	4.4	-0.9	-0.5	-2.1
Seen a psychiatrist for nerves, anxiety, tension or depression	2.3	2.9	7.9	-0.5	-0.8	-2.8
Wheeze or whistling in the chest in last year	0.1	0.1	0.3	-0.2	-0.2	0.6
Number of children fathered	0.4	0.4	0.8	-0.4	0.9	0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.8	1.0	1.7	1.1	-1.3	0.1
Age at first live birth	0.2	0.3	0.7	-0.9	0.3	0.4
Pulse wave peak to peak time	1.1	1.3	2.0	1.3	-0.6	-1.4
Health satisfaction	2.2	2.8	6.6	0.7	-2.6	-1.2
Shortness of breath walking on level ground	1.1	1.3	3.4	1.9	0.7	0.3
Qualifications: College or University degree	0.7	2.3	5.6	0.4	-1.1	-2.4
Eye problems/disorders: None of the above	1.4	1.6	2.1	1.4	-1.2	-1.1
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.7	0.8	0.2	0.2
Emphysema/chronic bronchitis	0.6	0.7	2.0	0.4	-1.4	-0.1
Medication for pain relief, constipation, heartburn	1.6	2.7	4.6	1.2	-1.5	-2.1
Neck or shoulder pain in last month	0.2	0.3	0.4	0.5	0.6	0.4
Medication: Blood pressure	0.8	1.4	3.1	-1.8	1.0	0.3
Angina (self-reported)	1.2	1.6	2.7	-0.5	1.6	1.4
Migraine (self-reported)	1.2	1.4	2.2	-1.4	0.4	-1.5
Medication: Ibuprofen	1.4	1.7	2.6	0.1	1.5	1.6
Medication: Allopurinol	0.3	0.4	0.7	0.6	0.8	-0.5
Medication: Omeprazole	0.4	0.5	0.9	0.6	-1.0	0.5
Medication: Seretide 50 evohaler	0.8	0.9	1.4	0.7	-1.2	0.8
Mean time to correctly identify matches	0.2	0.5	0.7	-0.4	0.9	-0.7
Heart disease (mother)	0.4	0.5	0.7	-0.5	-0.7	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.1	-0.2	1.1	0.8
Whole body fat mass	0.9	3.7	7.9	1.2	1.2	2.8
Leg fat mass (right)	0.5	2.0	3.5	1.9	0.0	1.6
Arm predicted mass (right)	1.5	7.9	10.8	3.3	-2.2	2.9
Pulse rate, automated reading	0.1	0.4	0.9	1.0	0.5	-0.2
Alcohol intake frequency.	1.8	4.2	7.2	-2.0	2.7	1.1
Comparative height size at age 10	1.2	6.6	14.1	-0.8	2.3	3.8
Number of full sisters	0.7	0.9	2.3	0.4	-1.5	-0.4
Suffer from ‘nerves’	4.5	7.0	15.2	-0.1	-2.4	-3.9
Overall health rating	0.1	0.3	0.9	0.1	-0.9	-0.0
Chest pain or discomfort	1.1	1.6	2.0	-1.1	-1.2	-1.4
Had major operations	0.5	0.6	1.3	-1.1	0.6	-0.3
Age at last live birth	0.5	0.8	1.7	0.1	-1.3	-0.8
Family relationship satisfaction	0.4	0.5	0.7	-0.6	0.6	-0.8
Leg pain on walking	0.3	0.3	0.8	-0.9	0.4	0.2
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	1.5	1.2	0.6	1.0
Commuting to job workplace: Car/motor vehicle	2.2	2.5	6.5	-0.1	1.1	2.5
Illness, injury, bereavement, stress in last 2 years	1.9	2.3	6.0	-2.4	0.8	-0.6
Medication: Aspirin	0.1	0.1	0.1	-0.3	0.2	-0.3
Supplements: Vitamin C	0.1	0.2	0.3	-0.3	-0.6	0.3
Knee pain experienced in last month	0.8	1.2	3.2	-0.5	0.5	1.8
Hypertension (Self-reported)	1.3	3.5	7.3	-2.7	0.9	1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	0.7	-0.7	-0.1	0.8
Illnesses of father: Heart disease	0.2	0.2	0.6	0.3	-0.2	0.7
Illnesses of siblings: Diabetes	0.4	0.5	0.7	-0.9	0.5	0.8
Smoking status: Previous	0.1	0.1	0.2	-0.3	0.5	0.3
Forced expiratory volume in 1-second (FEV1), predicted	1.8	3.8	9.8	-0.1	1.3	3.1
Whole body fat-free mass	1.5	8.5	17.6	2.5	-1.3	4.2
Leg fat-free mass (right)	1.8	9.4	26.4	1.3	-0.2	5.1
Arm fat percentage (left)	0.9	3.6	5.6	0.1	2.3	2.4
Average weekly red wine intake	0.2	0.4	0.7	-0.2	0.9	0.5
Handedness (chirality/laterality): Left-handed	0.6	0.8	1.1	1.1	0.6	-0.9
Mood swings	0.4	0.8	2.3	-0.4	0.1	-1.5
Loneliness, isolation	0.7	0.9	1.5	0.4	1.2	-1.1
Long-standing illness, disability or infirmity	0.8	1.2	3.5	-1.9	0.1	-0.0
Ever had bowel cancer screening	0.3	0.4	0.9	0.3	-0.3	1.0
Diabetes diagnosed by doctor	3.1	5.1	7.9	-0.5	2.7	2.8
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	2.3	-1.5	0.1	0.8
Friendships satisfaction	1.6	1.9	4.6	-0.6	-0.9	-2.1
Qualifications: nursing, teaching	0.2	0.3	0.4	-0.6	0.6	0.3
Commuting to job workplace: Walk	1.8	1.9	5.5	0.5	-0.0	-2.4
Eye problems/disorders: Cataract	1.3	1.5	2.5	-1.3	-0.4	1.6
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	1.6	-0.7	1.2	-0.0
Medication for cholesterol	0.9	1.4	2.6	1.3	0.0	-1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	1.3	-0.8	-1.0	1.1
Back pain experienced in last month	0.1	0.1	0.1	0.4	-0.3	0.2
Mineral and other dietary supplements	0.9	1.3	2.8	-0.5	0.9	-1.7
Breast cancer (self-reported)	0.7	0.9	1.8	-1.4	-0.0	-0.9
Asthma (self-reported)	0.7	1.5	3.5	0.9	-1.9	-0.1
Osteoporosis (self-reported)	0.6	0.7	1.6	-0.5	-1.3	-0.4
Osteoarthritis (self-reported)	1.1	1.4	1.7	1.1	-1.1	1.3
Medication: Aspirin	0.2	0.2	0.4	-0.6	0.6	-0.0
Medication: Gliclazide	1.2	1.3	2.8	0.8	0.7	1.7
Illnesses of father: None of the above (group 1)	0.3	0.3	0.9	-0.0	-0.3	-1.0
Smoking status: Current	0.2	0.4	0.5	0.5	-0.5	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.2	4.7	9.9	1.2	-1.7	-3.2
Whole body water mass	1.4	8.1	16.6	2.5	-1.2	4.1
Leg predicted mass (right)	1.8	9.4	26.2	1.4	-0.3	5.1
Arm fat mass (left)	0.9	3.6	8.7	0.9	1.2	2.9
Number of self-reported non-cancer illnesses	1.1	1.9	4.0	-2.0	0.4	1.2
Average weekly champagne plus white wine intake	0.4	0.5	0.8	-0.6	0.6	-0.9
Miserableness	1.9	3.3	9.2	0.9	-0.2	-3.0
Guilty feelings	1.9	2.9	7.6	0.1	-1.0	-2.7
Wears glasses or contact lenses	0.9	1.1	2.5	-1.6	-0.6	-0.6
Ever taken oral contraceptive pill	0.2	0.2	0.6	-0.2	0.1	0.8
Hearing aid user	2.1	2.4	6.0	-2.5	0.7	0.9
Mother’s age at death	0.8	1.0	1.2	-1.1	0.8	-1.1
Financial situation satisfaction	1.0	1.2	2.9	1.7	-0.7	-0.4
Tinnitus: Yes, now most or all of the time	3.3	3.9	5.5	-2.3	1.1	2.2
Commuting to job workplace: Public transport	2.9	3.5	8.3	0.4	-1.4	-2.9
Eye problems/disorders: Glaucoma	0.6	0.7	1.8	-1.3	0.5	0.4
Medication: Blood pressure	0.5	1.0	2.2	-1.5	0.1	1.0
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.2	0.1	-0.4	-0.1
Supplements: Fish oil (including cod liver oil)	1.2	1.5	2.8	1.2	-0.7	1.7
High cholesterol (Self-reported)	0.7	1.2	2.0	-1.2	1.4	-0.2
Medication: Bendroflumethiazide	0.4	0.6	0.8	-0.8	-0.9	0.5
Medication: Paracetamol	1.1	1.7	2.5	-1.1	1.6	1.3
Medication: Lisinopril	0.4	0.6	0.9	0.7	-0.9	0.5
Medication: Atorvastatin	0.9	1.1	2.2	-0.3	1.5	0.9
Illnesses of father: High blood pressure	0.7	0.9	1.4	-1.1	-1.2	-0.3
Alcohol drinker status: Never	1.4	1.7	3.6	-1.0	1.9	0.7
Ever smoked	0.2	0.3	0.8	0.9	0.2	-0.3
Basal metabolic rate	1.4	7.9	18.1	2.3	-0.6	4.2
Leg fat percentage (left)	0.2	0.6	1.6	1.3	0.4	0.3
Arm fat-free mass (left)	1.4	7.0	11.2	2.7	-1.5	3.3
Number of operations (self-reported)	0.3	0.4	1.1	-0.2	0.2	1.0
Average weekly beer plus cider intake	0.6	0.8	1.3	-0.8	-0.7	1.2
Irritability	1.7	2.8	8.1	0.5	-0.3	-2.8
Risk taking	0.8	1.2	2.8	-0.9	-1.7	-0.4
Ever had prostate specific antigen (PSA) test	0.1	0.2	0.5	-0.2	-0.7	0.0
Fractured/broken bones in last 5 years	0.2	0.3	0.5	-0.7	0.2	0.6
Age started oral contraceptive pill	1.4	1.8	3.6	0.7	-1.9	-1.1
Diastolic blood pressure, automated reading	1.2	3.6	7.5	-1.8	0.2	2.7
Ever depressed for a whole week	1.9	2.3	6.2	-0.1	-0.9	-2.5
Unable to work because of sickness or disability	0.1	0.1	0.3	-0.5	-0.3	0.2
Commuting to job workplace: Cycle	1.6	1.9	3.3	-1.8	-0.7	-1.4
Myopia	0.7	1.0	2.2	-1.5	-0.1	-0.8
Vascular/heart problems diagnosed by doctor	1.7	4.7	9.9	3.1	-1.3	-1.6
Cholesterol lowering medication	0.4	0.7	0.9	-0.9	0.6	0.9
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	1.1	1.0	-1.1	0.8
Pain experienced in last month	0.4	0.7	1.1	1.1	-0.7	-0.7
Supplements: Calcium	1.8	2.0	3.7	1.5	-1.9	-0.1
Basal cell carcinoma (self-reported)	1.4	1.7	5.0	2.2	0.0	0.1
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.4	1.2	0.0	-0.7
Deep venous thrombosis (DVT) (self-reported)	1.1	1.4	3.5	-0.1	-0.8	-1.9
Heart disease (siblings)	0.6	0.7	1.6	0.4	0.7	1.2
Alcohol drinker status: Previous	0.2	0.2	0.2	-0.4	0.4	0.4
Pack years of smoking	0.2	0.3	0.4	0.6	-0.5	-0.6
Impedance of whole body	1.5	7.5	13.1	-3.1	3.6	-0.1
Leg fat mass (left)	0.6	2.2	3.7	1.7	0.1	1.9
Arm predicted mass (left)	1.4	6.9	11.2	2.6	-1.6	3.4