TWAS hub - AATK

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Lung	0.1491	0.0576	8.9e-03	0.102	NA	0.087	NA	0.091	3.2e-08	NA	3.3e-07	NA	1.8e-07
2	GTEx	Ovary	0.3560	0.1090	2.2e-03	-0.011	NA	-0.007	NA	0.005	7.7e-01	NA	5.0e-01	NA	2.3e-01
3	NTR	Blood	0.0625	0.0159	1.4e-06	0.059	0.027	0.053	0.056	0.056	2.4e-18	3.3e-09	1.5e-16	1.8e-17	1.7e-17
4	YFS	Blood	0.0553	0.0155	3.5e-06	0.036	0.018	0.027	0.032	0.032	5.8e-12	9.2e-07	3.3e-09	9.4e-11	8.6e-11
5	TCGA	Pancreatic Adenocarcinoma	0.1560	0.0620	3.3e-03	0.022	0.057	0.033	NA	0.012	3.9e-02	2.2e-03	1.6e-02	NA	1.0e-01
6	TCGA	Stomach Adenocarcinoma	0.0630	0.0320	8.7e-03	0.030	0.038	0.034	NA	0.030	3.1e-03	9.5e-04	1.7e-03	NA	2.9e-03
7	TCGA	Testicular Germ Cell Tumors	0.2880	0.0910	2.9e-04	0.146	0.078	0.084	NA	0.108	7.7e-06	1.0e-03	6.9e-04	NA	1.2e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Seen doctor (GP) for nerves, anxiety, tension or depression	4.3	6.6	13.9	-1.9	1.8	-2.1	-2.2	-1.8	-3.7	-3.5
Current tobacco smoking	3.7	6.1	29.1	-1.4	1.6	-0.4	-0.3	-1.8	-2.4	-5.4
Smoking status: Current	3.6	5.7	27.6	-1.3	1.2	-0.5	-0.4	-1.7	-2.4	-5.3
Fasting Glucose	3.5	4.1	11.1	2.1	-1.6	1.1	1.1	2.4	3.3	1.6
Neuroticism (Nagel 2018)	3.4	7.9	50.7	-0.5	-0.5	-1.3	-1.4	-0.7	-0.6	-7.1
Worry (Nagel 2018)	3.3	6.9	33.5	0.2	-0.9	-2.6	-2.6	0.5	-0.6	-5.8
Tense / ‘highly strung’	3.2	5.2	22.6	0.3	-1.1	-2.4	-2.4	1.3	-0.0	-4.8
Age when periods started (menarche)	2.9	6.9	15.7	0.7	4.0	3.6	3.6	1.4	1.9	-0.2
Back pain experienced in last month	2.8	4.1	10.9	-0.2	-1.0	-2.1	-2.1	-1.9	-2.1	-3.3
Depression (Nagel 2018)	2.7	4.1	21.3	-0.4	-0.1	-1.5	-1.5	-1.0	-1.4	-4.6
Neuroticism	2.6	6.3	41.0	-0.5	0.5	-0.5	-0.5	-0.8	-1.1	-6.4
Neuroticism score	2.6	5.4	36.1	-0.2	-0.5	-0.8	-0.8	-0.4	-0.6	-6.0
Frequency of tenseness / restlessness in last 2 weeks	2.5	3.8	23.4	-0.6	-0.2	-0.3	-0.3	-1.5	-0.7	-4.8
Depressed Affect (Nagel 2018)	2.3	4.9	27.7	-1.4	-0.1	-0.0	-0.1	-1.7	-1.4	-5.3
Ever used hormone-replacement therapy (HRT)	2.3	2.9	5.5	1.4	-1.8	-2.1	-2.2	-0.0	-0.1	-2.4
Worrier / anxious feelings	2.3	4.4	10.2	0.2	-2.0	-2.8	-2.9	0.4	-0.5	-3.2
Frequency of tiredness / lethargy in last 2 weeks	2.3	3.7	23.0	0.1	-1.5	-0.1	-0.0	-0.6	-0.5	-4.8
Depression (self-reported)	2.3	2.8	9.4	0.9	-0.6	-2.0	-2.1	-0.2	-0.4	-3.1
Seen a psychiatrist for nerves, anxiety, tension or depression	2.3	2.9	7.2	-2.4	1.0	0.0	-0.0	-1.9	-2.7	-1.9
Heart disease (mother)	2.3	2.8	6.1	1.7	-1.5	-2.5	-2.5	1.1	0.9	0.0
Suffer from ‘nerves’	2.3	3.6	22.8	-0.9	0.4	-0.2	-0.3	-0.5	-1.0	-4.8
Sensitivity / hurt feelings	2.2	3.8	13.7	1.9	-0.5	-1.1	-1.1	1.9	1.6	-3.7
Systolic blood pressure, automated reading	2.2	6.3	15.1	0.7	-3.3	-3.8	-3.9	0.8	-1.4	-0.5
Guilty feelings	2.2	3.3	18.2	-0.6	0.6	-1.1	-1.1	-1.1	-0.9	-4.3
Ever depressed for a whole week	2.2	2.8	7.2	-0.2	-0.1	-2.7	-2.7	-0.4	-0.8	-2.0
Smoking Status	2.1	5.0	19.2	-1.7	1.8	-0.4	-0.4	-1.8	-2.5	-4.4
Frequency of depressed mood in last 2 weeks	2.1	2.9	17.6	0.1	-0.7	-1.0	-1.0	-0.6	-0.3	-4.2
Diverticular disease/diverticulitis (self-reported)	2.1	2.5	9.1	1.0	-3.0	-1.6	-1.6	1.2	0.9	-0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.1	2.4	6.5	1.1	-0.7	-2.5	-2.6	1.5	-0.1	0.1
Deep venous thrombosis (DVT) (self-reported)	2.1	2.7	8.1	0.5	-0.1	2.8	2.8	-0.6	0.5	-1.4
Age at First Birth	2.0	2.8	6.6	-0.4	-0.6	-2.4	-2.5	0.9	-0.5	2.6
Number of children fathered	2.0	2.3	5.9	-0.2	1.2	-2.4	-2.4	-0.4	-0.9	-1.3
Ever smoked	2.0	3.5	18.1	-1.0	0.2	-0.6	-0.6	-1.7	-1.3	-4.3
Systolic Blood Pressure	1.9	9.4	25.8	1.0	-2.8	-5.0	-5.1	2.0	-1.0	1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.9	2.5	15.0	0.1	-0.0	-1.0	-1.0	-0.2	-0.7	-3.9
Emphysema/chronic bronchitis	1.9	2.2	5.1	2.1	-1.6	0.2	0.2	0.6	1.5	-2.3
Chest pain or discomfort	1.9	2.7	10.7	2.1	-1.2	-0.2	-0.1	0.5	1.4	-3.3
Neuroticism (2016)	1.8	2.5	14.7	-0.3	1.5	-0.3	-0.3	-0.7	-0.1	-3.8
High blood pressure (mother)	1.8	2.6	7.3	-1.0	-0.1	-1.5	-1.5	-1.5	-1.8	-2.7
Blood clot in the leg (DVT)	1.8	2.4	6.9	0.4	0.0	2.6	2.6	-0.8	0.3	-1.4
Overall health rating	1.8	3.8	22.8	-0.1	0.2	0.0	0.1	-1.7	-0.8	-4.8
Medication: Co-codamol	1.7	2.0	4.8	-2.2	1.3	-0.5	-0.5	-1.2	-2.2	-0.6
Mouth/teeth dental problems	1.7	2.6	15.2	-0.5	0.5	0.8	0.8	1.2	0.3	3.9
Trunk fat-free mass	1.7	9.5	27.1	-0.2	-0.2	5.2	5.2	-2.5	1.3	2.3
Trunk predicted mass	1.7	9.6	27.6	-0.2	-0.2	5.2	5.2	-2.4	1.3	2.2
Other serious medical condition/disability diagnosed by doctor	1.6	2.1	4.9	-0.8	1.8	2.2	2.2	-0.9	-0.1	-0.3
Eye problems/disorders: Diabetes related eye disease	1.6	1.7	5.3	-0.2	0.4	-1.7	-1.7	-0.8	0.0	-2.3
Heel bone mineral density (BMD) T-score, automated (right)	1.6	3.6	7.5	2.7	-1.9	-1.1	-1.0	2.7	2.0	-0.7
Neck or shoulder pain in last month	1.6	2.3	8.8	-0.6	-1.8	0.8	0.8	-1.2	-1.0	-3.0
Number of self-reported non-cancer illnesses	1.6	2.7	8.3	0.3	-0.4	-2.8	-2.9	-0.2	-0.9	-1.2
Miserableness	1.6	2.8	13.6	0.0	-0.9	-1.5	-1.5	-0.5	0.1	-3.7
Medication: Lisinopril	1.6	2.1	5.0	0.7	-1.1	-2.2	-2.2	1.5	-0.2	0.9
Alzheimer’s Disease (in mother)	1.5	1.8	3.9	2.0	-0.5	0.9	0.8	1.3	2.0	1.1
LDL Cholesterol	1.5	2.4	5.4	0.2	-1.4	2.3	2.3	0.4	1.7	0.9
Medication for hormone replacement therapy	1.5	1.7	2.8	1.4	-1.7	-1.2	-1.1	1.4	1.4	0.5
Average weekly fortified wine intake	1.5	1.8	5.1	0.2	0.5	2.2	2.3	0.4	1.2	0.7
Hair/balding pattern: Pattern 2	1.5	1.9	3.8	0.1	1.9	-1.9	-1.8	-1.3	-0.7	-0.8
Forced vital capacity (FVC)	1.5	5.9	14.5	-1.5	2.2	3.8	3.8	-2.0	0.4	1.3
Pulse rate	1.5	2.5	5.4	-1.4	-1.4	-2.2	-2.3	-0.9	-1.1	-0.9
Prospective memory result	1.5	1.9	8.2	1.4	-2.9	0.3	0.3	0.6	0.8	1.4
Forced expiratory volume in 1-second (FEV1), Best measure	1.5	4.9	14.1	-0.4	1.5	3.7	3.8	-1.3	0.9	1.1
Forced vital capacity (FVC), Best measure	1.5	5.6	14.4	-1.1	1.9	3.7	3.8	-1.9	0.5	1.4
Mouth/teeth dental problems: Loose teeth	1.5	1.7	6.5	1.3	-0.9	-1.3	-1.2	-0.2	0.2	-2.5
Whole body fat-free mass	1.5	8.3	23.8	-0.0	-0.5	4.8	4.9	-2.2	1.4	2.0
Loneliness, isolation	1.5	2.1	9.1	-1.7	0.4	0.7	0.7	-1.1	-0.6	-3.0
Medication: Gliclazide	1.5	1.7	4.6	-0.4	-0.6	-2.1	-2.1	-1.3	-0.8	0.4
Tinnitus: Yes, now most or all of the time	1.5	1.8	4.7	-0.1	1.1	-2.2	-2.1	-0.4	-1.2	-0.1
Arm fat-free mass (left)	1.5	7.7	23.3	-0.2	0.2	4.8	4.8	-2.4	1.0	0.9
Intelligence (Savage-Jansen 2018)	1.4	4.2	16.8	-1.1	-0.0	0.5	0.4	-3.2	-0.9	-4.1
Respiratory disease	1.4	3.0	8.6	2.2	-0.9	0.2	0.1	2.1	2.9	-1.5
Stomach or abdominal pain in last month	1.4	1.8	3.2	1.7	-1.6	-1.2	-1.2	0.4	0.9	-1.8
Nervous feelings	1.4	2.6	12.7	0.1	-0.9	-1.5	-1.5	0.0	-0.4	-3.6
Illnesses of father: None of the above (group 1)	1.4	1.7	3.3	0.1	1.0	1.4	1.4	1.8	0.9	1.7
Whole body water mass	1.4	8.0	23.0	-0.0	-0.5	4.7	4.8	-2.3	1.4	1.8
Basal cell carcinoma (self-reported)	1.4	1.7	5.2	2.3	1.2	0.3	0.3	1.4	1.5	1.0
Arm predicted mass (left)	1.4	7.1	21.3	0.0	-0.0	4.5	4.6	-2.2	1.1	1.2
Alzheimer’s Disease (including proxy)	1.3	1.9	5.3	2.3	-0.5	1.0	1.0	0.8	1.9	1.2
Crohns Disease (2017)	1.3	3.0	4.5	-1.3	2.1	-2.0	-2.1	-1.2	-1.7	1.2
Blood White Count	1.3	9.6	28.2	-0.4	-1.1	-3.4	-3.4	-3.5	-1.4	-5.3
BMI	1.3	7.5	14.4	-0.1	-0.2	3.8	3.8	-3.8	0.7	-3.0
Forced expiratory volume in 1-second (FEV1)	1.3	4.4	12.1	-0.6	1.4	3.4	3.5	-1.5	0.8	1.1
Exposure to tobacco smoke at home	1.3	1.4	2.7	0.2	1.1	-1.6	-1.7	-1.2	-0.8	-1.2
Wheeze or whistling in the chest in last year	1.3	2.3	7.2	2.1	-0.5	-0.8	-0.9	0.9	1.3	-2.7
Pulse wave peak to peak time	1.3	1.6	4.1	-1.2	1.1	2.0	2.0	-0.4	-0.2	0.4
Forced expiratory volume in 1-second (FEV1), predicted	1.3	2.6	5.6	0.8	0.1	2.3	2.4	1.1	1.6	1.8
Hearing aid user	1.3	1.5	3.3	1.3	-0.4	1.8	1.8	-0.7	0.6	-0.9
Basal metabolic rate	1.3	7.4	21.5	0.2	-0.4	4.6	4.6	-2.1	1.4	1.7
Commuting to job workplace: Cycle	1.3	1.5	4.5	1.3	-0.6	1.2	1.3	0.6	2.1	0.9
Chronotype (morning person)	1.2	2.8	6.0	0.2	-2.4	-2.2	-2.3	1.7	-0.3	0.3
Supplements: Zinc	1.2	1.3	3.0	1.7	0.3	-0.2	-0.2	1.3	1.6	1.3
Leg fat-free mass (left)	1.2	6.2	17.6	0.2	-1.0	4.1	4.2	-1.9	1.4	1.5
Taking other prescription medications	1.2	1.9	4.1	1.3	0.5	-2.0	-2.0	1.2	0.0	-1.3
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.7	6.4	2.5	-2.0	-1.0	-1.0	2.0	1.6	0.2
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	4.8	-0.6	0.7	-0.5	-0.4	-2.2	-0.9	-1.4
Serious illness, injury or assault to yourself	1.2	1.5	3.8	-1.1	0.6	0.3	0.2	-2.0	-1.5	-1.6
Medication: Atenolol	1.2	1.5	3.1	1.8	0.8	-1.5	-1.5	1.3	0.5	0.5
Sitting height	1.2	8.3	19.3	-0.7	0.2	4.4	4.4	0.2	0.7	4.3
Leg predicted mass (left)	1.2	6.5	18.4	0.3	-1.0	4.2	4.3	-1.9	1.6	1.5
Standing height	1.2	11.7	29.7	-0.1	0.0	5.4	5.5	-0.4	1.9	4.4
Hair/balding pattern: Pattern 4	1.2	2.9	6.7	0.6	0.9	2.6	2.5	2.2	1.3	-0.0
Migraine (self-reported)	1.2	1.5	4.1	-1.3	2.0	-0.8	-0.7	-0.8	-0.7	-1.5
Arm predicted mass (right)	1.2	6.1	16.2	-0.4	-0.1	4.0	4.0	-2.8	0.7	1.4
Commuting to job workplace: Car/motor vehicle	1.2	1.4	4.4	-1.7	0.6	-0.0	-0.1	-1.1	-2.1	0.7
Mood swings	1.2	2.1	9.4	0.3	-0.8	-1.3	-1.3	-1.2	-0.1	-3.1
Commuting to job workplace: Walk	1.2	1.3	2.2	-0.5	1.4	-1.5	-1.5	-1.1	-0.7	-0.5
Supplements: Fish oil (including cod liver oil)	1.2	1.6	4.0	-0.2	-0.6	-1.7	-1.7	-1.0	-0.0	2.0
Rheumatoid Arthritis	1.1	1.6	3.5	-0.3	1.2	1.3	1.3	-1.9	-0.2	-1.6
Type 2 Diabetes (T2D) (2018)	1.1	2.1	3.3	0.3	-1.8	-1.7	-1.7	-1.6	-0.3	-1.8
Severe depression (siblings)	1.1	1.3	2.3	-0.7	1.4	-1.2	-1.2	-0.2	-1.1	-1.5
Fed-up feelings	1.1	2.1	11.2	-0.3	0.1	1.2	1.2	-0.5	0.3	-3.4
Chronic bronchitis/emphysema (father)	1.1	1.3	5.8	-0.4	-0.8	-0.6	-0.6	-1.4	0.0	-2.4
Diabetes (self-reported)	1.1	1.6	4.5	-0.3	-0.8	-2.1	-2.1	-1.0	-0.7	-0.8
Falls in the last year	1.1	1.4	3.8	-1.4	0.2	-0.3	-0.2	-1.4	-2.0	-1.5
Illnesses of mother	1.1	1.4	3.3	-0.5	1.8	1.4	1.5	0.3	0.2	1.4
Gout (self-reported)	1.1	1.5	4.4	2.1	-1.3	-1.1	-1.1	-0.7	1.2	-0.2
Arm fat-free mass (right)	1.1	5.7	15.1	-0.2	-0.3	3.9	3.9	-2.6	0.9	1.6
Exposure to tobacco smoke outside home	1.1	1.4	2.8	0.4	1.0	1.6	1.7	-0.9	1.1	-1.3
Medication: Omeprazole	1.1	1.3	3.2	1.3	0.2	1.1	1.1	0.9	1.1	-1.8
Alcohol intake frequency.	1.1	2.5	4.8	0.8	-0.4	1.7	1.7	1.4	2.0	2.2
Medication: Aspirin	1.1	1.4	3.0	1.4	1.0	-1.4	-1.5	0.0	0.0	-1.7
Medication for cholesterol	1.1	1.7	4.0	-1.2	1.1	1.9	2.0	-0.8	-0.6	0.6
Osteoarthritis (self-reported)	1.1	1.4	3.8	-0.8	-0.7	1.2	1.2	-1.9	-1.1	0.8
Medication: Bendroflumethiazide	1.1	1.7	5.1	-0.3	-1.0	-2.2	-2.3	0.7	-0.6	0.1
Illnesses of father: High blood pressure	1.1	1.4	2.7	-1.6	0.8	-0.8	-0.8	-1.2	-1.6	-1.1
Ever had prostate specific antigen (PSA) test	1.1	1.3	3.0	-0.0	1.7	-1.3	-1.3	-0.3	-1.4	0.8
Diastolic blood pressure, automated reading	1.1	3.3	9.2	-0.0	-3.0	-2.5	-2.5	0.5	-1.0	0.5
Supplements: Calcium	1.1	1.2	3.6	0.5	-0.9	0.2	0.2	1.7	0.9	1.9
Height	1.0	18.8	44.9	0.3	1.3	6.2	6.2	-1.0	2.5	6.7
Number of treatments/medications taken	1.0	1.8	5.7	0.1	-0.8	-2.4	-2.4	-0.5	-0.3	-0.2
Angina	1.0	1.3	3.1	0.8	0.3	-1.8	-1.8	-0.6	-0.6	-1.2
Fluid intelligence score	1.0	2.1	13.4	0.2	0.2	0.4	0.3	-0.8	-0.4	-3.7
Weight	1.0	4.7	14.1	0.3	-0.0	3.7	3.8	-2.0	0.8	0.4
Pulse wave reflection index	1.0	1.2	3.9	2.0	-1.1	-0.3	-0.2	1.3	1.3	0.2
Qualifications: O levels/GCSEs or equivalent	1.0	1.5	3.6	1.9	0.1	1.2	1.2	0.9	1.9	-0.0
Mouth/teeth dental problems: Bleeding gums	1.0	1.2	5.2	0.4	-0.8	-0.9	-0.9	-1.0	0.2	-2.3
Medication for cholesterol, blood pressure or diabetes	1.0	1.7	4.8	0.3	1.2	2.1	2.2	0.5	0.8	0.1
Glaucoma (self-reported)	1.0	1.2	6.3	-0.6	-2.5	0.1	0.1	0.1	-0.5	1.2
Chronic bronchitis/emphysema (mother)	1.0	1.2	2.9	1.7	-0.9	0.5	0.5	1.1	1.4	-1.0
Worry too long after embarrassment	1.0	1.7	8.9	1.0	-0.4	0.2	0.2	0.5	1.2	-3.0
Health satisfaction	1.0	1.3	2.8	1.7	-0.6	1.0	1.0	0.4	1.7	-0.9
Angina (self-reported)	1.0	1.3	3.2	1.1	0.2	-1.8	-1.8	-0.2	-0.4	-1.1
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	4.0	0.2	-0.5	-0.1	-0.1	1.9	0.7	2.0
Supplements: Vitamin C	1.0	1.2	5.0	0.7	-1.3	0.4	0.4	0.5	0.7	2.2
Leg fat-free mass (right)	1.0	5.3	13.5	0.4	-1.4	3.6	3.7	-1.5	1.5	1.9
Diabetes diagnosed by doctor	1.0	1.7	4.0	-0.2	-1.2	-2.0	-2.0	-1.1	-0.4	-0.9
Osteoporosis (self-reported)	1.0	1.3	3.9	0.4	-1.7	0.2	0.2	0.7	1.1	2.0
Prostate Cancer	0.9	1.2	2.8	0.7	1.7	1.2	1.2	1.2	0.9	-0.1
Waist Hip Ratio (WHR)	0.9	3.8	10.0	-1.4	0.5	-1.4	-1.6	-3.0	-1.0	-3.2
Cardiovascular Disease	0.9	2.9	6.3	0.3	-2.5	-2.0	-2.0	-1.7	-0.9	-1.6
Bilateral oophorectomy (both ovaries removed)	0.9	1.1	2.5	-0.7	1.2	0.7	0.8	-0.5	-1.4	-1.6
Past tobacco smoking	0.9	1.7	7.5	1.1	-0.4	-0.0	0.0	1.4	1.1	2.7
Had menopause	0.9	1.1	6.4	0.7	-2.5	-0.1	-0.1	0.2	1.0	0.3
Number of live births	0.9	1.3	2.6	0.5	0.7	1.6	1.6	-1.1	0.5	-1.4
Qualifications: A levels/AS levels or equivalent	0.9	2.0	4.7	1.1	0.5	1.9	1.9	0.1	2.2	-1.0
Medication: Cholesterol lowering	0.9	1.3	3.4	0.4	-0.6	-1.8	-1.8	-1.1	-0.7	-0.6
Lung cancer (father)	0.9	1.1	2.1	1.4	-0.4	-1.0	-1.1	1.3	0.9	-0.7
Pulse wave Arterial Stiffness index	0.9	1.0	2.5	1.1	-0.9	-1.6	-1.5	0.5	0.3	-0.1
Length of working week for main job	0.9	1.0	1.9	-1.4	1.2	-0.2	-0.2	-1.3	-1.2	-0.5
Ever highly irritable/argumentative for 2 days	0.9	1.1	4.2	-0.5	0.0	-0.8	-0.8	-1.3	-0.3	-2.1
Medication: Amlodipine	0.9	1.3	2.9	1.7	-0.8	0.3	0.4	1.4	1.7	0.4
Shortness of breath walking on level ground	0.9	1.1	3.3	1.1	-0.8	0.9	0.8	1.1	1.8	0.1
Comparative height size at age 10	0.9	5.0	14.4	-0.3	-1.4	3.8	3.8	-0.7	0.7	1.8
Had major operations	0.9	1.1	6.4	0.0	0.8	-0.2	-0.2	-0.8	0.2	-2.5
Age at last live birth	0.9	1.2	2.7	0.7	-1.0	1.6	1.6	0.3	1.3	0.5
Knee pain experienced in last month	0.9	1.4	3.3	0.7	0.5	1.8	1.8	-0.6	0.5	-1.4
Friendships satisfaction	0.9	1.1	5.9	0.8	-0.6	-0.6	-0.6	0.3	0.4	-2.4
Medication: Aspirin	0.9	1.2	3.3	1.6	0.2	-1.0	-1.0	-0.1	0.5	-1.8
Leg predicted mass (right)	0.9	5.1	12.8	0.4	-1.3	3.5	3.6	-1.5	1.5	1.9
Wears glasses or contact lenses	0.9	1.0	3.5	-1.8	0.4	-0.1	-0.2	0.1	-1.9	0.0
Ever taken oral contraceptive pill	0.9	1.0	4.3	0.9	-1.0	0.1	0.1	-0.7	0.3	-2.1
Number of operations (self-reported)	0.9	1.3	7.8	0.2	0.6	0.6	0.6	0.4	0.0	-2.8
Irritability	0.9	1.6	9.4	0.1	0.8	-0.5	-0.6	0.4	0.2	-3.1
Lung FVC	0.8	4.3	9.9	-0.8	2.5	3.1	3.1	-1.6	0.0	0.9
Hand grip strength (left)	0.8	2.1	5.5	-0.3	0.2	2.3	2.3	-1.0	1.1	1.3
Ever had hysterectomy (womb removed)	0.8	0.9	2.2	0.4	0.1	-1.5	-1.5	0.6	-0.1	-1.3
Medication: Metformin	0.8	1.1	3.0	0.0	-0.8	-1.2	-1.3	-1.7	-0.9	-0.1
Townsend deprivation index at recruitment	0.8	1.2	3.0	-0.7	1.2	1.7	1.7	-0.5	-0.2	-0.3
Pain all over the body in last month	0.8	0.8	2.6	0.2	0.3	-1.6	-1.6	-0.1	-0.6	-0.2
Breastfed as a baby	0.8	1.0	3.5	1.9	-0.6	-1.1	-1.0	0.7	0.8	-0.2
Medication: Paracetamol	0.8	1.4	3.1	-1.8	1.2	0.0	0.1	-1.5	-1.7	-0.2
Number of full brothers	0.8	1.1	1.7	1.3	0.9	1.3	1.3	1.1	0.7	0.3
Medication: Blood pressure	0.8	1.4	4.2	0.3	-0.8	-2.0	-2.1	0.8	-0.4	-0.2
Medication: Ibuprofen	0.8	0.9	2.5	1.6	-0.8	0.5	0.5	0.4	1.6	-0.5
Medication: Allopurinol	0.8	1.0	3.6	1.0	-0.6	-0.7	-0.7	-1.9	0.3	-0.9
Hypertension (Self-reported)	0.8	2.2	4.2	1.3	-2.0	-2.0	-2.0	0.9	-0.2	-0.8
Illnesses of father: Heart disease	0.8	1.1	2.2	1.0	-1.0	-1.5	-1.5	1.0	-0.3	-0.1
Average weekly red wine intake	0.8	1.1	3.1	1.7	0.1	-0.9	-0.8	1.1	1.5	0.4
Mouth/teeth dental problems: Mouth ulcers	0.8	1.2	2.7	1.4	0.0	0.6	0.6	1.2	1.6	-1.5
Asthma (self-reported)	0.8	1.6	5.6	1.2	-0.2	-0.8	-0.8	2.4	1.6	0.1
Verbal and Numeric Reasoning (VNR)	0.7	1.7	7.1	-0.5	0.3	-0.2	-0.2	-1.9	-1.1	-2.7
Mean Putamen Volume	0.7	0.7	3.2	0.4	-0.8	0.5	0.5	0.8	0.0	1.8
Diabetes (father)	0.7	0.9	3.3	0.8	-1.1	-0.5	-0.6	-0.7	-0.0	-1.8
Hand grip strength (right)	0.7	2.0	5.3	1.3	-0.6	1.5	1.5	-0.2	2.3	1.5
Number of incorrect matches in round	0.7	1.2	3.3	0.1	-0.5	-1.8	-1.8	1.0	-0.3	0.7
Noisy workplace	0.7	0.9	2.4	1.6	-0.7	-0.5	-0.4	-0.2	1.4	-0.7
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	2.3	0.1	1.4	0.1	0.1	-0.7	-0.8	-1.5
Asthma	0.7	1.3	4.6	1.1	-0.1	-0.7	-0.7	2.1	1.5	-0.2
Leg fat percentage (right)	0.7	2.4	7.7	-0.3	1.1	1.2	1.2	-1.9	-1.1	-2.8
Mother’s age at death	0.7	0.9	2.2	-0.6	-0.4	-1.0	-1.1	-1.5	-0.7	-0.9
Financial situation satisfaction	0.7	0.9	2.0	1.2	-0.4	-0.7	-0.7	-0.5	1.2	-1.4
Eye problems/disorders: Glaucoma	0.7	0.8	4.2	-0.5	-2.0	0.2	0.1	-0.6	-0.7	0.8
Medication: Paracetamol	0.7	1.1	2.6	-1.3	1.6	0.9	0.9	-1.1	-0.8	-0.0
Average weekly beer plus cider intake	0.7	1.1	1.8	-0.7	-0.6	-1.3	-1.3	-0.9	-1.4	-0.8
Risk taking	0.7	1.1	5.3	0.2	-0.4	1.0	1.0	0.1	-0.1	-2.3
Age started oral contraceptive pill	0.7	0.9	3.3	1.2	-0.5	0.1	0.2	0.3	1.8	1.1
Pain experienced in last month	0.7	1.2	4.8	-0.2	0.2	0.4	0.3	1.4	1.1	2.2
Breast Cancer	0.6	1.5	3.5	1.2	-0.7	1.0	1.0	1.9	1.8	0.0
Lupus	0.6	0.8	2.7	-1.5	-1.6	0.2	0.2	-0.5	-0.5	0.6
Diabetes (mother)	0.6	0.8	1.3	-0.5	0.7	0.9	1.0	-1.0	-0.7	-1.2
Pack years adult smoking proportion	0.6	1.0	1.7	0.7	0.8	1.3	1.3	-0.9	0.7	-1.0
High blood pressure	0.6	1.6	3.1	1.4	-1.8	-1.5	-1.6	1.1	0.1	-0.2
Waist circumference	0.6	2.2	8.1	-0.6	0.6	1.5	1.5	-2.9	-0.3	-1.4
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	2.4	-0.1	0.5	-0.7	-0.7	-1.1	-0.6	-1.6
Medication: Simvastatin	0.6	0.9	2.6	0.0	-0.1	-1.6	-1.6	-0.1	-1.0	-0.6
Hip circumference	0.6	2.6	7.2	-0.4	0.5	2.7	2.7	-1.8	-0.1	0.5
Mouth/teeth dental problems: Dentures	0.6	1.0	3.1	-0.6	-0.2	-0.5	-0.6	-1.2	-1.3	-1.8
Medication: Lansoprazole	0.6	0.6	1.4	-0.9	-0.9	-0.7	-0.8	0.1	-1.2	-0.7
Arm fat mass (right)	0.6	2.5	6.5	0.5	0.4	2.5	2.5	-1.6	0.5	-1.1
Peak expiratory flow (PEF)	0.6	1.5	4.8	0.2	-0.2	2.1	2.2	-0.5	0.7	0.3
Comparative body size at age 10	0.6	1.8	10.1	-0.8	-1.2	-0.2	-0.1	-3.2	-0.0	0.1
Medication for pain relief, constipation, heartburn	0.6	1.0	2.1	-1.0	0.0	1.5	1.4	-0.1	0.3	1.5
Leg fat mass (right)	0.6	2.3	4.8	-0.1	0.6	2.0	2.1	-2.2	-0.4	-1.6
Number of full sisters	0.6	0.8	1.5	0.9	-0.0	1.2	1.2	-0.3	1.0	0.9
Mineral and other dietary supplements	0.6	0.9	4.2	0.1	1.1	0.1	0.1	0.6	-0.3	-2.0
Arm fat mass (left)	0.6	2.3	6.1	0.6	0.5	2.5	2.5	-1.5	0.6	-0.9
Pain type(s) experienced in last month: Hip pain	0.6	0.7	2.9	0.8	0.7	0.0	0.0	-1.1	0.2	-1.7
Vascular/heart problems diagnosed by doctor	0.6	1.5	3.7	-1.3	1.9	1.4	1.5	-0.9	-0.1	0.4
Cholesterol lowering medication	0.6	0.9	3.1	1.8	-0.2	-0.6	-0.7	1.2	0.9	-0.3
Alcohol drinker status: Previous	0.6	0.7	2.1	0.8	-1.4	-0.4	-0.4	1.2	0.2	-0.2
Irritable Bowel Disease (IBD)	0.5	1.3	2.9	-0.4	0.9	-1.3	-1.4	-0.8	-0.8	1.7
Body Mass Index (BMI) (2010)	0.5	0.7	2.5	-0.2	-1.0	0.8	0.8	-1.6	-0.1	0.0
Ulcerative Colitis	0.5	0.7	1.6	1.0	-0.1	1.1	0.0	-1.3	1.0	0.0
Lung FEV1/FVC ratio	0.5	2.5	4.8	2.2	0.0	1.5	1.6	2.2	1.8	0.5
Average weekly spirits intake	0.5	0.6	1.5	0.6	0.3	-1.2	-1.2	0.3	-0.4	-0.7
Vitamin and mineral supplements	0.5	0.7	2.5	-0.5	1.6	-0.1	-0.2	-0.1	-1.0	-1.0
Multivitamins +/- minerals	0.5	0.7	2.1	0.7	-1.5	0.3	0.3	-0.5	1.0	0.9
Hearing difficulty/problems with background noise	0.5	0.8	3.7	-0.9	0.4	-0.1	-0.1	-1.9	-0.8	-0.8
Illnesses of siblings	0.5	0.7	1.6	-0.6	1.3	0.9	0.9	0.4	0.8	0.3
Time employed in main current job	0.5	0.5	1.7	0.2	0.6	-0.2	-0.2	1.3	0.2	1.3
Impedance of arm (left)	0.5	2.2	10.8	0.5	0.7	-0.8	-0.9	3.3	0.7	1.3
Birth weight	0.5	1.1	2.4	-1.6	0.8	0.8	0.7	-1.4	-1.2	0.2
Age at first live birth	0.5	0.9	2.0	0.3	-0.9	1.4	1.4	-0.1	1.1	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.8	0.1	0.6	-1.3	-1.3	0.6	-0.3	0.1
Ever had bowel cancer screening	0.5	0.6	1.3	1.1	-0.3	-1.0	-1.0	1.0	0.3	0.2
Breast cancer (self-reported)	0.5	0.5	3.2	0.1	1.8	0.5	0.5	0.3	0.3	0.1
Commuting to job workplace: Public transport	0.5	0.6	1.6	1.3	-0.6	0.1	0.1	0.8	1.2	0.2
Leg fat percentage (left)	0.5	1.7	6.3	0.0	0.9	0.7	0.7	-1.7	-1.0	-2.5
Fractured/broken bones in last 5 years	0.5	0.6	1.6	-0.9	1.3	0.2	0.1	-0.9	-0.3	-0.9
Heart disease (siblings)	0.5	0.6	1.5	-0.4	0.0	-0.8	-0.9	-1.1	-1.2	-0.4
Alzheimer’s Disease (in father)	0.4	0.5	1.1	0.5	0.1	1.1	1.1	-0.7	0.4	-0.3
Ovarian Cancer	0.4	0.6	2.6	0.8	0.0	0.6	0.5	1.6	0.2	-0.5
Blood Red Count	0.4	4.3	16.6	1.9	-4.1	-1.8	-1.7	-1.0	1.8	0.1
Hearing difficulty/problems: Yes	0.4	0.6	1.5	0.1	-1.1	0.6	0.7	-1.2	0.6	-0.5
Supplements: Glucosamine	0.4	0.5	1.8	0.3	-1.4	0.2	0.2	-1.1	0.4	-0.1
Body mass index (BMI)	0.4	1.5	4.3	0.4	-0.0	1.4	1.4	-2.1	-0.1	-1.5
Impedance of leg (left)	0.4	2.2	4.1	-0.3	1.9	-1.9	-2.0	1.6	-1.0	-0.7
Trunk fat mass	0.4	1.9	5.3	0.9	0.3	2.3	2.3	-1.0	0.6	-0.5
Qualifications: None of the above	0.4	0.9	1.6	-0.3	1.1	-1.2	-1.2	-0.0	-1.3	-0.7
Financial difficulties in last 2 years	0.4	0.5	1.0	0.6	0.9	-0.8	-0.8	0.0	-0.3	-1.0
Impedance of arm (right)	0.4	2.1	11.4	0.5	0.9	-0.8	-0.8	3.4	0.6	0.7
Arm fat percentage (right)	0.4	1.6	5.0	1.0	0.4	1.4	1.4	-0.7	0.5	-2.2
Father’s age at death	0.4	0.6	1.5	-0.9	1.2	0.1	0.0	0.5	-0.9	0.6
Happiness	0.4	0.5	1.7	0.5	-0.1	-0.9	-0.9	-0.1	-0.1	-1.3
Loud music exposure frequency	0.4	0.5	0.9	-0.3	0.7	-0.9	-0.9	-0.8	-0.4	0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.1	-0.7	-0.5	-0.3	-0.3	-0.9	-1.1	0.6
Whole body fat mass	0.4	1.8	4.8	0.7	0.4	2.2	2.2	-1.2	0.5	-0.9
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.8	-0.3	-0.3	0.8	0.7	-1.3	-0.2	-0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	0.8	-0.3	0.0	0.8	0.8	-0.9	-0.7	-0.8
Medication: Blood pressure	0.4	0.8	2.2	0.6	-0.6	-1.4	-1.5	0.7	0.2	0.1
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	2.4	0.7	0.4	0.6	0.5	0.3	0.2	-1.5
Pack years of smoking	0.4	0.6	0.9	0.7	0.6	0.9	0.9	-0.9	0.5	-0.9
Impedance of whole body	0.4	2.1	7.8	0.1	1.3	-1.5	-1.6	2.8	0.0	0.6
Leg fat mass (left)	0.4	1.6	3.6	0.1	0.4	1.7	1.7	-1.9	-0.2	-1.3
Bipolar Disorder (2018)	0.3	0.4	2.2	-0.7	-0.1	0.5	0.0	0.4	0.0	-1.5
Schizophrenia vs Biploar Disorder	0.3	0.4	2.5	0.2	-0.6	1.6	0.0	0.0	0.0	0.0
Ulcerative Colitis (UC)	0.3	0.6	2.3	0.7	-0.4	0.3	0.3	0.1	1.0	1.5
Crohns Disease (2012)	0.3	0.5	1.8	-1.0	1.3	-0.6	-0.7	0.0	0.0	0.0
HbA1C	0.3	0.3	0.9	-0.5	0.4	-0.1	-0.1	-0.5	-0.9	0.6
Triglycerides	0.3	0.5	1.0	-0.5	0.6	1.0	1.0	-0.2	-0.4	0.8
Blood Eosinophil Count	0.3	2.3	14.0	0.9	0.0	0.6	0.6	-0.4	0.6	-3.7
Blood Platelet Count	0.3	3.2	5.7	-2.1	0.5	2.0	2.0	-2.4	-1.0	-1.7
Heel T-Score	0.3	2.0	5.3	0.8	-0.6	-2.3	-2.3	1.0	0.5	-1.1
Relative age of first facial hair	0.3	0.6	2.6	-0.1	0.1	0.7	0.7	-0.5	-0.0	-1.6
Impedance of leg (right)	0.3	1.2	4.4	-0.5	2.1	-0.7	-0.8	1.1	-0.8	-1.0
Qualifications: CSEs or equivalent	0.3	0.4	1.6	0.3	-1.2	-0.3	-0.3	0.9	0.1	0.6
Heart attack	0.3	0.4	1.4	1.2	-0.1	-0.4	-0.4	0.2	0.5	-1.0
Medication: Ramipril	0.3	0.3	1.1	-0.2	-0.2	-0.9	-1.0	0.2	-0.6	-0.0
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.3	0.6	0.8	-0.5	-0.6	-0.6	-0.0	0.5	-0.7
Medication: Ventolin 100micrograms inhaler	0.3	0.3	0.8	-0.3	0.5	-0.9	-0.8	0.0	0.3	0.7
High blood pressure (siblings)	0.3	0.5	2.0	1.4	0.1	-0.4	-0.4	0.8	0.0	-0.6
Body fat percentage	0.3	1.1	3.1	0.8	0.7	1.2	1.2	-0.5	0.2	-1.8
Qualifications: College or University degree	0.3	1.1	2.6	0.3	-0.7	1.3	1.4	0.5	1.6	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	1.8	-0.4	-0.2	0.4	0.5	-0.3	-0.3	1.4
Pulse rate, automated reading	0.3	0.8	1.3	-0.8	-1.0	-1.0	-1.0	-0.9	-0.3	-1.1
Family relationship satisfaction	0.3	0.4	1.5	-0.5	-0.1	0.7	0.7	0.1	0.5	-1.2
Illnesses of siblings: Diabetes	0.3	0.3	0.6	-0.3	-0.8	-0.4	-0.4	-0.6	-0.8	-0.5
Smoking status: Previous	0.3	0.5	1.2	-1.1	0.6	0.4	0.3	-0.9	-0.6	-0.7
Arm fat percentage (left)	0.3	1.4	3.8	1.0	0.3	1.3	1.3	-0.8	0.5	-2.0
Long-standing illness, disability or infirmity	0.3	0.5	1.2	0.4	0.2	0.6	0.5	-0.9	0.7	-1.1
Qualifications: nursing, teaching	0.3	0.5	1.0	-0.6	0.8	0.9	1.0	-0.6	-0.1	0.6
Eye problems/disorders: Cataract	0.3	0.4	0.7	0.1	0.3	0.8	0.8	0.6	0.8	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	2.1	-0.4	1.4	1.1	1.0	-0.2	-0.2	0.0
High cholesterol (Self-reported)	0.3	0.5	1.2	1.0	-0.3	-1.1	-1.1	0.2	0.2	-0.5
Medication: Atorvastatin	0.3	0.3	1.2	0.8	0.6	0.2	0.2	-1.1	0.4	0.0
Alcohol drinker status: Never	0.3	0.4	1.2	-0.5	-0.2	0.6	0.6	-0.5	1.1	0.1
Myopia	0.3	0.4	1.0	-0.9	0.0	-1.0	-1.0	0.6	-0.2	0.1
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.4	1.2	0.1	-0.5	-0.4	0.3	0.7	-0.6
Schizophrenia (2018)	0.2	0.4	1.5	0.8	1.2	-0.1	-0.1	0.6	-0.3	0.2
Reaction Time	0.2	0.4	1.1	0.6	1.1	-0.5	-0.4	-0.7	-0.3	-0.7
Coronary Artery Disease (CAD)	0.2	0.2	1.4	-0.5	-1.2	-0.2	0.0	0.0	0.0	0.0
HDL Cholesterol	0.2	0.3	1.1	0.3	-0.2	0.5	0.5	-0.4	1.1	-0.7
Primary Biliary Cirrhosis	0.2	0.3	0.9	-0.1	0.8	0.5	0.5	-0.9	-0.4	-0.2
Schizophrenia (2014)	0.2	0.4	1.2	0.3	1.1	1.0	0.0	0.0	-0.4	-0.2
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.7	0.7	-0.1	0.6	0.0	-0.8	0.3	0.0
Hair Pigment	0.2	5.6	31.4	-0.6	-5.6	-1.3	-1.3	0.2	-0.4	2.0
Trunk fat percentage	0.2	0.7	1.2	1.0	0.6	1.1	1.1	-0.2	0.4	-1.1
Maternal smoking around birth	0.2	0.2	0.8	-0.0	-0.1	0.5	0.6	-0.9	-0.2	-0.5
Relative age voice broke	0.2	0.3	0.8	0.0	-0.3	0.7	0.8	0.1	0.6	-0.9
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.5	0.2	-0.1	-0.6	-0.7	-0.3	0.3	-0.6
Headache pain in last month	0.2	0.3	0.7	0.2	-0.4	-0.8	-0.8	0.7	-0.0	-0.2
Eye problems/disorders: None of the above	0.2	0.3	1.4	0.1	0.2	0.3	0.4	-0.5	-0.0	1.2
Medication: Seretide 50 evohaler	0.2	0.2	0.7	-0.2	0.6	0.0	0.0	-0.3	-0.6	-0.8
Mean time to correctly identify matches	0.2	0.4	1.4	1.2	0.8	-0.6	-0.5	0.1	-0.2	0.1
Leg pain on walking	0.2	0.3	0.9	0.5	0.4	0.3	0.2	-0.8	0.2	-1.0
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.8	-0.6	-0.9	-0.3	-0.4	0.6	0.1	0.0
Average weekly champagne plus white wine intake	0.2	0.2	0.8	-0.7	0.0	0.3	0.2	-0.4	0.2	0.9
Unable to work because of sickness or disability	0.2	0.2	0.5	-0.4	0.7	-0.3	-0.4	-0.2	-0.3	-0.7
Bipolar Disorder or Schizophrenia	0.1	0.3	0.6	0.2	0.8	0.6	0.0	0.7	-0.2	-0.6
Allergy or Eczema	0.1	0.2	0.7	-0.4	0.6	-0.0	-0.0	-0.8	0.5	0.4
Hypothyroidism (self reported)	0.1	0.3	1.8	0.1	1.3	0.1	0.1	0.1	0.3	-0.1
Tanning	0.1	0.7	3.6	0.3	1.9	-0.4	-0.4	0.1	-0.3	-1.0
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.5	-0.3	0.7	-0.6	-0.6	-0.6	0.1	0.2
Alcohol usually taken with meals	0.1	0.2	0.5	0.0	-0.5	-0.5	-0.4	0.1	0.7	0.1
Had other major operations	0.1	0.2	0.5	-0.7	0.4	0.4	0.4	-0.5	-0.2	0.1
Allergy	0.1	0.3	1.3	-0.1	-0.3	0.1	0.2	-0.1	-0.6	1.1
Alcohol intake versus 10 years previously	0.1	0.2	0.4	-0.2	-0.3	0.6	0.6	-0.3	0.4	-0.3
Hair/balding pattern: Pattern 3	0.1	0.2	0.6	0.2	-0.7	0.3	0.4	0.3	-0.3	-0.1
Birth weight of first child	0.1	0.2	0.7	0.1	0.3	-0.3	-0.3	-0.4	-0.4	-0.8
Hypothyroidism/myxoedema (self-reported)	0.1	0.1	0.6	-0.1	0.8	-0.3	-0.2	-0.4	0.1	-0.2
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Medication: Levothyroxine sodium	0.0	0.1	0.1	0.2	0.2	0.3	0.4	0.3	0.3	0.2

Hub : Genes

AATK

Models

Trait associations