Hub : Genes

AATK

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Lung 0.1491 0.0576 8.9e-03 0.102 NA 0.087 NA 0.091 3.2e-08 NA 3.3e-07 NA 1.8e-07
2 GTEx Ovary 0.3560 0.1090 2.2e-03 -0.011 NA -0.007 NA 0.005 7.7e-01 NA 5.0e-01 NA 2.3e-01
3 NTR Blood 0.0625 0.0159 1.4e-06 0.059 0.027 0.053 0.056 0.056 2.4e-18 3.3e-09 1.5e-16 1.8e-17 1.7e-17
4 YFS Blood 0.0553 0.0155 3.5e-06 0.036 0.018 0.027 0.032 0.032 5.8e-12 9.2e-07 3.3e-09 9.4e-11 8.6e-11
5 TCGA Pancreatic Adenocarcinoma 0.1560 0.0620 3.3e-03 0.022 0.057 0.033 NA 0.012 3.9e-02 2.2e-03 1.6e-02 NA 1.0e-01
6 TCGA Stomach Adenocarcinoma 0.0630 0.0320 8.7e-03 0.030 0.038 0.034 NA 0.030 3.1e-03 9.5e-04 1.7e-03 NA 2.9e-03
7 TCGA Testicular Germ Cell Tumors 0.2880 0.0910 2.9e-04 0.146 0.078 0.084 NA 0.108 7.7e-06 1.0e-03 6.9e-04 NA 1.2e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 0.3 0.4 2.2 -0.7 -0.1 0.5 0.0 0.4 0.0 -1.5
Bipolar Disorder or Schizophrenia 0.1 0.3 0.6 0.2 0.8 0.6 0.0 0.7 -0.2 -0.6
Depressed Affect (Nagel 2018) 2.3 4.9 27.7 -1.4 -0.1 -0.0 -0.1 -1.7 -1.4 -5.3
Depression (Nagel 2018) 2.7 4.1 21.3 -0.4 -0.1 -1.5 -1.5 -1.0 -1.4 -4.6
Intelligence (Savage-Jansen 2018) 1.4 4.2 16.8 -1.1 -0.0 0.5 0.4 -3.2 -0.9 -4.1
Neuroticism (Nagel 2018) 3.4 7.9 50.7 -0.5 -0.5 -1.3 -1.4 -0.7 -0.6 -7.1
Schizophrenia (2018) 0.2 0.4 1.5 0.8 1.2 -0.1 -0.1 0.6 -0.3 0.2
Schizophrenia vs Biploar Disorder 0.3 0.4 2.5 0.2 -0.6 1.6 0.0 0.0 0.0 0.0
Worry (Nagel 2018) 3.3 6.9 33.5 0.2 -0.9 -2.6 -2.6 0.5 -0.6 -5.8
Alzheimer’s Disease (in mother) 1.5 1.8 3.9 2.0 -0.5 0.9 0.8 1.3 2.0 1.1
Alzheimer’s Disease (in father) 0.4 0.5 1.1 0.5 0.1 1.1 1.1 -0.7 0.4 -0.3
Alzheimer’s Disease (including proxy) 1.3 1.9 5.3 2.3 -0.5 1.0 1.0 0.8 1.9 1.2
Crohns Disease (2017) 1.3 3.0 4.5 -1.3 2.1 -2.0 -2.1 -1.2 -1.7 1.2
Irritable Bowel Disease (IBD) 0.5 1.3 2.9 -0.4 0.9 -1.3 -1.4 -0.8 -0.8 1.7
Ulcerative Colitis (UC) 0.3 0.6 2.3 0.7 -0.4 0.3 0.3 0.1 1.0 1.5
Major Depression (MDD) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Reaction Time 0.2 0.4 1.1 0.6 1.1 -0.5 -0.4 -0.7 -0.3 -0.7
Verbal and Numeric Reasoning (VNR) 0.7 1.7 7.1 -0.5 0.3 -0.2 -0.2 -1.9 -1.1 -2.7
Breast Cancer 0.6 1.5 3.5 1.2 -0.7 1.0 1.0 1.9 1.8 0.0
Ovarian Cancer 0.4 0.6 2.6 0.8 0.0 0.6 0.5 1.6 0.2 -0.5
Prostate Cancer 0.9 1.2 2.8 0.7 1.7 1.2 1.2 1.2 0.9 -0.1
Age at First Birth 2.0 2.8 6.6 -0.4 -0.6 -2.4 -2.5 0.9 -0.5 2.6
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.5 0.7 2.5 -0.2 -1.0 0.8 0.8 -1.6 -0.1 0.0
Coronary Artery Disease (CAD) 0.2 0.2 1.4 -0.5 -1.2 -0.2 0.0 0.0 0.0 0.0
Crohns Disease (2012) 0.3 0.5 1.8 -1.0 1.3 -0.6 -0.7 0.0 0.0 0.0
Mean Putamen Volume 0.7 0.7 3.2 0.4 -0.8 0.5 0.5 0.8 0.0 1.8
Fasting Glucose 3.5 4.1 11.1 2.1 -1.6 1.1 1.1 2.4 3.3 1.6
HbA1C 0.3 0.3 0.9 -0.5 0.4 -0.1 -0.1 -0.5 -0.9 0.6
HDL Cholesterol 0.2 0.3 1.1 0.3 -0.2 0.5 0.5 -0.4 1.1 -0.7
LDL Cholesterol 1.5 2.4 5.4 0.2 -1.4 2.3 2.3 0.4 1.7 0.9
Lupus 0.6 0.8 2.7 -1.5 -1.6 0.2 0.2 -0.5 -0.5 0.6
Neuroticism (2016) 1.8 2.5 14.7 -0.3 1.5 -0.3 -0.3 -0.7 -0.1 -3.8
Primary Biliary Cirrhosis 0.2 0.3 0.9 -0.1 0.8 0.5 0.5 -0.9 -0.4 -0.2
Rheumatoid Arthritis 1.1 1.6 3.5 -0.3 1.2 1.3 1.3 -1.9 -0.2 -1.6
Schizophrenia (2014) 0.2 0.4 1.2 0.3 1.1 1.0 0.0 0.0 -0.4 -0.2
Triglycerides 0.3 0.5 1.0 -0.5 0.6 1.0 1.0 -0.2 -0.4 0.8
Type 2 Diabetes (T2D) (2012) 0.2 0.2 0.7 0.7 -0.1 0.6 0.0 -0.8 0.3 0.0
Ulcerative Colitis 0.5 0.7 1.6 1.0 -0.1 1.1 0.0 -1.3 1.0 0.0
Blood Eosinophil Count 0.3 2.3 14.0 0.9 0.0 0.6 0.6 -0.4 0.6 -3.7
Blood Platelet Count 0.3 3.2 5.7 -2.1 0.5 2.0 2.0 -2.4 -1.0 -1.7
Blood Red Count 0.4 4.3 16.6 1.9 -4.1 -1.8 -1.7 -1.0 1.8 0.1
Blood White Count 1.3 9.6 28.2 -0.4 -1.1 -3.4 -3.4 -3.5 -1.4 -5.3
Heel T-Score 0.3 2.0 5.3 0.8 -0.6 -2.3 -2.3 1.0 0.5 -1.1
BMI 1.3 7.5 14.4 -0.1 -0.2 3.8 3.8 -3.8 0.7 -3.0
Height 1.0 18.8 44.9 0.3 1.3 6.2 6.2 -1.0 2.5 6.7
Waist Hip Ratio (WHR) 0.9 3.8 10.0 -1.4 0.5 -1.4 -1.6 -3.0 -1.0 -3.2
Systolic Blood Pressure 1.9 9.4 25.8 1.0 -2.8 -5.0 -5.1 2.0 -1.0 1.2
Smoking Status 2.1 5.0 19.2 -1.7 1.8 -0.4 -0.4 -1.8 -2.5 -4.4
Allergy or Eczema 0.1 0.2 0.7 -0.4 0.6 -0.0 -0.0 -0.8 0.5 0.4
Cardiovascular Disease 0.9 2.9 6.3 0.3 -2.5 -2.0 -2.0 -1.7 -0.9 -1.6
Hypothyroidism (self reported) 0.1 0.3 1.8 0.1 1.3 0.1 0.1 0.1 0.3 -0.1
Respiratory disease 1.4 3.0 8.6 2.2 -0.9 0.2 0.1 2.1 2.9 -1.5
Type 2 Diabetes (T2D) (2018) 1.1 2.1 3.3 0.3 -1.8 -1.7 -1.7 -1.6 -0.3 -1.8
Lung FEV1/FVC ratio 0.5 2.5 4.8 2.2 0.0 1.5 1.6 2.2 1.8 0.5
Lung FVC 0.8 4.3 9.9 -0.8 2.5 3.1 3.1 -1.6 0.0 0.9
Neuroticism 2.6 6.3 41.0 -0.5 0.5 -0.5 -0.5 -0.8 -1.1 -6.4
Chronotype (morning person) 1.2 2.8 6.0 0.2 -2.4 -2.2 -2.3 1.7 -0.3 0.3
Hair Pigment 0.2 5.6 31.4 -0.6 -5.6 -1.3 -1.3 0.2 -0.4 2.0
Tanning 0.1 0.7 3.6 0.3 1.9 -0.4 -0.4 0.1 -0.3 -1.0
Hand grip strength (left) 0.8 2.1 5.5 -0.3 0.2 2.3 2.3 -1.0 1.1 1.3
Number of treatments/medications taken 1.0 1.8 5.7 0.1 -0.8 -2.4 -2.4 -0.5 -0.3 -0.2
Average weekly spirits intake 0.5 0.6 1.5 0.6 0.3 -1.2 -1.2 0.3 -0.4 -0.7
Sensitivity / hurt feelings 2.2 3.8 13.7 1.9 -0.5 -1.1 -1.1 1.9 1.6 -3.7
Frequency of depressed mood in last 2 weeks 2.1 2.9 17.6 0.1 -0.7 -1.0 -1.0 -0.6 -0.3 -4.2
Hearing difficulty/problems: Yes 0.4 0.6 1.5 0.1 -1.1 0.6 0.7 -1.2 0.6 -0.5
Relative age of first facial hair 0.3 0.6 2.6 -0.1 0.1 0.7 0.7 -0.5 -0.0 -1.6
Other serious medical condition/disability diagnosed by doctor 1.6 2.1 4.9 -0.8 1.8 2.2 2.2 -0.9 -0.1 -0.3
Ever used hormone-replacement therapy (HRT) 2.3 2.9 5.5 1.4 -1.8 -2.1 -2.2 -0.0 -0.1 -2.4
Ever had hysterectomy (womb removed) 0.8 0.9 2.2 0.4 0.1 -1.5 -1.5 0.6 -0.1 -1.3
Systolic blood pressure, automated reading 2.2 6.3 15.1 0.7 -3.3 -3.8 -3.9 0.8 -1.4 -0.5
Eye problems/disorders: Diabetes related eye disease 1.6 1.7 5.3 -0.2 0.4 -1.7 -1.7 -0.8 0.0 -2.3
Angina 1.0 1.3 3.1 0.8 0.3 -1.8 -1.8 -0.6 -0.6 -1.2
Medication for hormone replacement therapy 1.5 1.7 2.8 1.4 -1.7 -1.2 -1.1 1.4 1.4 0.5
Vitamin and mineral supplements 0.5 0.7 2.5 -0.5 1.6 -0.1 -0.2 -0.1 -1.0 -1.0
Supplements: Zinc 1.2 1.3 3.0 1.7 0.3 -0.2 -0.2 1.3 1.6 1.3
Medication: Co-codamol 1.7 2.0 4.8 -2.2 1.3 -0.5 -0.5 -1.2 -2.2 -0.6
Medication: Metformin 0.8 1.1 3.0 0.0 -0.8 -1.2 -1.3 -1.7 -0.9 -0.1
Diabetes (father) 0.7 0.9 3.3 0.8 -1.1 -0.5 -0.6 -0.7 -0.0 -1.8
Diabetes (mother) 0.6 0.8 1.3 -0.5 0.7 0.9 1.0 -1.0 -0.7 -1.2
Severe depression (siblings) 1.1 1.3 2.3 -0.7 1.4 -1.2 -1.2 -0.2 -1.1 -1.5
Pack years adult smoking proportion 0.6 1.0 1.7 0.7 0.8 1.3 1.3 -0.9 0.7 -1.0
Impedance of leg (right) 0.3 1.2 4.4 -0.5 2.1 -0.7 -0.8 1.1 -0.8 -1.0
Leg fat-free mass (left) 1.2 6.2 17.6 0.2 -1.0 4.1 4.2 -1.9 1.4 1.5
Trunk fat percentage 0.2 0.7 1.2 1.0 0.6 1.1 1.1 -0.2 0.4 -1.1
Hand grip strength (right) 0.7 2.0 5.3 1.3 -0.6 1.5 1.5 -0.2 2.3 1.5
Townsend deprivation index at recruitment 0.8 1.2 3.0 -0.7 1.2 1.7 1.7 -0.5 -0.2 -0.3
Current tobacco smoking 3.7 6.1 29.1 -1.4 1.6 -0.4 -0.3 -1.8 -2.4 -5.4
Average weekly fortified wine intake 1.5 1.8 5.1 0.2 0.5 2.2 2.3 0.4 1.2 0.7
Maternal smoking around birth 0.2 0.2 0.8 -0.0 -0.1 0.5 0.6 -0.9 -0.2 -0.5
Fed-up feelings 1.1 2.1 11.2 -0.3 0.1 1.2 1.2 -0.5 0.3 -3.4
Frequency of unenthusiasm / disinterest in last 2 weeks 1.9 2.5 15.0 0.1 -0.0 -1.0 -1.0 -0.2 -0.7 -3.9
Relative age voice broke 0.2 0.3 0.8 0.0 -0.3 0.7 0.8 0.1 0.6 -0.9
Taking other prescription medications 1.2 1.9 4.1 1.3 0.5 -2.0 -2.0 1.2 0.0 -1.3
Age when periods started (menarche) 2.9 6.9 15.7 0.7 4.0 3.6 3.6 1.4 1.9 -0.2
Bilateral oophorectomy (both ovaries removed) 0.9 1.1 2.5 -0.7 1.2 0.7 0.8 -0.5 -1.4 -1.6
Heel bone mineral density (BMD) T-score, automated (left) 1.2 2.7 6.4 2.5 -2.0 -1.0 -1.0 2.0 1.6 0.2
Tinnitus: Yes, but not now, but have in the past 1.2 1.3 4.8 -0.6 0.7 -0.5 -0.4 -2.2 -0.9 -1.4
Qualifications: CSEs or equivalent 0.3 0.4 1.6 0.3 -1.2 -0.3 -0.3 0.9 0.1 0.6
Serious illness, injury or assault to yourself 1.2 1.5 3.8 -1.1 0.6 0.3 0.2 -2.0 -1.5 -1.6
High blood pressure 0.6 1.6 3.1 1.4 -1.8 -1.5 -1.6 1.1 0.1 -0.2
Hayfever, allergic rhinitis or eczema 0.1 0.3 0.5 -0.3 0.7 -0.6 -0.6 -0.6 0.1 0.2
Multivitamins +/- minerals 0.5 0.7 2.1 0.7 -1.5 0.3 0.3 -0.5 1.0 0.9
Stomach or abdominal pain in last month 1.4 1.8 3.2 1.7 -1.6 -1.2 -1.2 0.4 0.9 -1.8
Supplements: Glucosamine 0.4 0.5 1.8 0.3 -1.4 0.2 0.2 -1.1 0.4 -0.1
Diverticular disease/diverticulitis (self-reported) 2.1 2.5 9.1 1.0 -3.0 -1.6 -1.6 1.2 0.9 -0.0
Medication: Atenolol 1.2 1.5 3.1 1.8 0.8 -1.5 -1.5 1.3 0.5 0.5
Medication: Levothyroxine sodium 0.0 0.1 0.1 0.2 0.2 0.3 0.4 0.3 0.3 0.2
Sitting height 1.2 8.3 19.3 -0.7 0.2 4.4 4.4 0.2 0.7 4.3
Chronic bronchitis/emphysema (father) 1.1 1.3 5.8 -0.4 -0.8 -0.6 -0.6 -1.4 0.0 -2.4
High blood pressure (mother) 1.8 2.6 7.3 -1.0 -0.1 -1.5 -1.5 -1.5 -1.8 -2.7
Body mass index (BMI) 0.4 1.5 4.3 0.4 -0.0 1.4 1.4 -2.1 -0.1 -1.5
Impedance of leg (left) 0.4 2.2 4.1 -0.3 1.9 -1.9 -2.0 1.6 -1.0 -0.7
Leg predicted mass (left) 1.2 6.5 18.4 0.3 -1.0 4.2 4.3 -1.9 1.6 1.5
Trunk fat mass 0.4 1.9 5.3 0.9 0.3 2.3 2.3 -1.0 0.6 -0.5
Waist circumference 0.6 2.2 8.1 -0.6 0.6 1.5 1.5 -2.9 -0.3 -1.4
Number of incorrect matches in round 0.7 1.2 3.3 0.1 -0.5 -1.8 -1.8 1.0 -0.3 0.7
Past tobacco smoking 0.9 1.7 7.5 1.1 -0.4 -0.0 0.0 1.4 1.1 2.7
Alcohol usually taken with meals 0.1 0.2 0.5 0.0 -0.5 -0.5 -0.4 0.1 0.7 0.1
Nervous feelings 1.4 2.6 12.7 0.1 -0.9 -1.5 -1.5 0.0 -0.4 -3.6
Frequency of tenseness / restlessness in last 2 weeks 2.5 3.8 23.4 -0.6 -0.2 -0.3 -0.3 -1.5 -0.7 -4.8
Hearing difficulty/problems with background noise 0.5 0.8 3.7 -0.9 0.4 -0.1 -0.1 -1.9 -0.8 -0.8
Hair/balding pattern: Pattern 2 1.5 1.9 3.8 0.1 1.9 -1.9 -1.8 -1.3 -0.7 -0.8
Had menopause 0.9 1.1 6.4 0.7 -2.5 -0.1 -0.1 0.2 1.0 0.3
Had other major operations 0.1 0.2 0.5 -0.7 0.4 0.4 0.4 -0.5 -0.2 0.1
Forced vital capacity (FVC) 1.5 5.9 14.5 -1.5 2.2 3.8 3.8 -2.0 0.4 1.3
Heel bone mineral density (BMD) T-score, automated (right) 1.6 3.6 7.5 2.7 -1.9 -1.1 -1.0 2.7 2.0 -0.7
Ever unenthusiastic/disinterested for a whole week 0.6 0.7 2.4 -0.1 0.5 -0.7 -0.7 -1.1 -0.6 -1.6
Qualifications: None of the above 0.4 0.9 1.6 -0.3 1.1 -1.2 -1.2 -0.0 -1.3 -0.7
Financial difficulties in last 2 years 0.4 0.5 1.0 0.6 0.9 -0.8 -0.8 0.0 -0.3 -1.0
Mouth/teeth dental problems 1.7 2.6 15.2 -0.5 0.5 0.8 0.8 1.2 0.3 3.9
Heart attack 0.3 0.4 1.4 1.2 -0.1 -0.4 -0.4 0.2 0.5 -1.0
Allergy 0.1 0.3 1.3 -0.1 -0.3 0.1 0.2 -0.1 -0.6 1.1
Pain all over the body in last month 0.8 0.8 2.6 0.2 0.3 -1.6 -1.6 -0.1 -0.6 -0.2
Diabetes (self-reported) 1.1 1.6 4.5 -0.3 -0.8 -2.1 -2.1 -1.0 -0.7 -0.8
Hayfever/allergic rhinitis (self-reported) 0.2 0.2 0.5 0.2 -0.1 -0.6 -0.7 -0.3 0.3 -0.6
Medication: Ramipril 0.3 0.3 1.1 -0.2 -0.2 -0.9 -1.0 0.2 -0.6 -0.0
Medication: Simvastatin 0.6 0.9 2.6 0.0 -0.1 -1.6 -1.6 -0.1 -1.0 -0.6
Fluid intelligence score 1.0 2.1 13.4 0.2 0.2 0.4 0.3 -0.8 -0.4 -3.7
Illnesses of siblings 0.5 0.7 1.6 -0.6 1.3 0.9 0.9 0.4 0.8 0.3
Neuroticism score 2.6 5.4 36.1 -0.2 -0.5 -0.8 -0.8 -0.4 -0.6 -6.0
Weight 1.0 4.7 14.1 0.3 -0.0 3.7 3.8 -2.0 0.8 0.4
Impedance of arm (right) 0.4 2.1 11.4 0.5 0.9 -0.8 -0.8 3.4 0.6 0.7
Arm fat percentage (right) 0.4 1.6 5.0 1.0 0.4 1.4 1.4 -0.7 0.5 -2.2
Trunk fat-free mass 1.7 9.5 27.1 -0.2 -0.2 5.2 5.2 -2.5 1.3 2.3
Hip circumference 0.6 2.6 7.2 -0.4 0.5 2.7 2.7 -1.8 -0.1 0.5
Time employed in main current job 0.5 0.5 1.7 0.2 0.6 -0.2 -0.2 1.3 0.2 1.3
Alcohol intake versus 10 years previously 0.1 0.2 0.4 -0.2 -0.3 0.6 0.6 -0.3 0.4 -0.3
Father’s age at death 0.4 0.6 1.5 -0.9 1.2 0.1 0.0 0.5 -0.9 0.6
Worrier / anxious feelings 2.3 4.4 10.2 0.2 -2.0 -2.8 -2.9 0.4 -0.5 -3.2
Frequency of tiredness / lethargy in last 2 weeks 2.3 3.7 23.0 0.1 -1.5 -0.1 -0.0 -0.6 -0.5 -4.8
Falls in the last year 1.1 1.4 3.8 -1.4 0.2 -0.3 -0.2 -1.4 -2.0 -1.5
Hair/balding pattern: Pattern 3 0.1 0.2 0.6 0.2 -0.7 0.3 0.4 0.3 -0.3 -0.1
Number of live births 0.9 1.3 2.6 0.5 0.7 1.6 1.6 -1.1 0.5 -1.4
Forced expiratory volume in 1-second (FEV1) 1.3 4.4 12.1 -0.6 1.4 3.4 3.5 -1.5 0.8 1.1
Pulse rate 1.5 2.5 5.4 -1.4 -1.4 -2.2 -2.3 -0.9 -1.1 -0.9
Happiness 0.4 0.5 1.7 0.5 -0.1 -0.9 -0.9 -0.1 -0.1 -1.3
Noisy workplace 0.7 0.9 2.4 1.6 -0.7 -0.5 -0.4 -0.2 1.4 -0.7
Qualifications: A levels/AS levels or equivalent 0.9 2.0 4.7 1.1 0.5 1.9 1.9 0.1 2.2 -1.0
Serious illness, injury or assault of a close relative in last 2 years 0.7 0.8 2.3 0.1 1.4 0.1 0.1 -0.7 -0.8 -1.5
Mouth/teeth dental problems: Dentures 0.6 1.0 3.1 -0.6 -0.2 -0.5 -0.6 -1.2 -1.3 -1.8
Asthma 0.7 1.3 4.6 1.1 -0.1 -0.7 -0.7 2.1 1.5 -0.2
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.3 0.6 0.8 -0.5 -0.6 -0.6 -0.0 0.5 -0.7
Medication: Cholesterol lowering 0.9 1.3 3.4 0.4 -0.6 -1.8 -1.8 -1.1 -0.7 -0.6
Depression (self-reported) 2.3 2.8 9.4 0.9 -0.6 -2.0 -2.1 -0.2 -0.4 -3.1
Medication: Lansoprazole 0.6 0.6 1.4 -0.9 -0.9 -0.7 -0.8 0.1 -1.2 -0.7
Prospective memory result 1.5 1.9 8.2 1.4 -2.9 0.3 0.3 0.6 0.8 1.4
Lung cancer (father) 0.9 1.1 2.1 1.4 -0.4 -1.0 -1.1 1.3 0.9 -0.7
Illnesses of mother 1.1 1.4 3.3 -0.5 1.8 1.4 1.5 0.3 0.2 1.4
Forced expiratory volume in 1-second (FEV1), Best measure 1.5 4.9 14.1 -0.4 1.5 3.7 3.8 -1.3 0.9 1.1
Pulse wave Arterial Stiffness index 0.9 1.0 2.5 1.1 -0.9 -1.6 -1.5 0.5 0.3 -0.1
Impedance of arm (left) 0.5 2.2 10.8 0.5 0.7 -0.8 -0.9 3.3 0.7 1.3
Arm fat mass (right) 0.6 2.5 6.5 0.5 0.4 2.5 2.5 -1.6 0.5 -1.1
Trunk predicted mass 1.7 9.6 27.6 -0.2 -0.2 5.2 5.2 -2.4 1.3 2.2
Standing height 1.2 11.7 29.7 -0.1 0.0 5.4 5.5 -0.4 1.9 4.4
Length of working week for main job 0.9 1.0 1.9 -1.4 1.2 -0.2 -0.2 -1.3 -1.2 -0.5
Exposure to tobacco smoke at home 1.3 1.4 2.7 0.2 1.1 -1.6 -1.7 -1.2 -0.8 -1.2
Breastfed as a baby 0.8 1.0 3.5 1.9 -0.6 -1.1 -1.0 0.7 0.8 -0.2
Tense / ‘highly strung’ 3.2 5.2 22.6 0.3 -1.1 -2.4 -2.4 1.3 -0.0 -4.8
Seen doctor (GP) for nerves, anxiety, tension or depression 4.3 6.6 13.9 -1.9 1.8 -2.1 -2.2 -1.8 -3.7 -3.5
Hair/balding pattern: Pattern 4 1.2 2.9 6.7 0.6 0.9 2.6 2.5 2.2 1.3 -0.0
Birth weight of first child 0.1 0.2 0.7 0.1 0.3 -0.3 -0.3 -0.4 -0.4 -0.8
Peak expiratory flow (PEF) 0.6 1.5 4.8 0.2 -0.2 2.1 2.2 -0.5 0.7 0.3
Pulse wave reflection index 1.0 1.2 3.9 2.0 -1.1 -0.3 -0.2 1.3 1.3 0.2
Ever highly irritable/argumentative for 2 days 0.9 1.1 4.2 -0.5 0.0 -0.8 -0.8 -1.3 -0.3 -2.1
Loud music exposure frequency 0.4 0.5 0.9 -0.3 0.7 -0.9 -0.9 -0.8 -0.4 0.1
Qualifications: O levels/GCSEs or equivalent 1.0 1.5 3.6 1.9 0.1 1.2 1.2 0.9 1.9 -0.0
Mouth/teeth dental problems: Bleeding gums 1.0 1.2 5.2 0.4 -0.8 -0.9 -0.9 -1.0 0.2 -2.3
Blood clot in the leg (DVT) 1.8 2.4 6.9 0.4 0.0 2.6 2.6 -0.8 0.3 -1.4
Medication: Paracetamol 0.8 1.4 3.1 -1.8 1.2 0.0 0.1 -1.5 -1.7 -0.2
Headache pain in last month 0.2 0.3 0.7 0.2 -0.4 -0.8 -0.8 0.7 -0.0 -0.2
Medication for cholesterol, blood pressure or diabetes 1.0 1.7 4.8 0.3 1.2 2.1 2.2 0.5 0.8 0.1
Glaucoma (self-reported) 1.0 1.2 6.3 -0.6 -2.5 0.1 0.1 0.1 -0.5 1.2
Gout (self-reported) 1.1 1.5 4.4 2.1 -1.3 -1.1 -1.1 -0.7 1.2 -0.2
Hypothyroidism/myxoedema (self-reported) 0.1 0.1 0.6 -0.1 0.8 -0.3 -0.2 -0.4 0.1 -0.2
Medication: Amlodipine 0.9 1.3 2.9 1.7 -0.8 0.3 0.4 1.4 1.7 0.4
Medication: Ventolin 100micrograms inhaler 0.3 0.3 0.8 -0.3 0.5 -0.9 -0.8 0.0 0.3 0.7
Birth weight 0.5 1.1 2.4 -1.6 0.8 0.8 0.7 -1.4 -1.2 0.2
Chronic bronchitis/emphysema (mother) 1.0 1.2 2.9 1.7 -0.9 0.5 0.5 1.1 1.4 -1.0
High blood pressure (siblings) 0.3 0.5 2.0 1.4 0.1 -0.4 -0.4 0.8 0.0 -0.6
Forced vital capacity (FVC), Best measure 1.5 5.6 14.4 -1.1 1.9 3.7 3.8 -1.9 0.5 1.4
Body fat percentage 0.3 1.1 3.1 0.8 0.7 1.2 1.2 -0.5 0.2 -1.8
Leg fat percentage (right) 0.7 2.4 7.7 -0.3 1.1 1.2 1.2 -1.9 -1.1 -2.8
Arm fat-free mass (right) 1.1 5.7 15.1 -0.2 -0.3 3.9 3.9 -2.6 0.9 1.6
Exposure to tobacco smoke outside home 1.1 1.4 2.8 0.4 1.0 1.6 1.7 -0.9 1.1 -1.3
Comparative body size at age 10 0.6 1.8 10.1 -0.8 -1.2 -0.2 -0.1 -3.2 -0.0 0.1
Number of full brothers 0.8 1.1 1.7 1.3 0.9 1.3 1.3 1.1 0.7 0.3
Worry too long after embarrassment 1.0 1.7 8.9 1.0 -0.4 0.2 0.2 0.5 1.2 -3.0
Seen a psychiatrist for nerves, anxiety, tension or depression 2.3 2.9 7.2 -2.4 1.0 0.0 -0.0 -1.9 -2.7 -1.9
Wheeze or whistling in the chest in last year 1.3 2.3 7.2 2.1 -0.5 -0.8 -0.9 0.9 1.3 -2.7
Number of children fathered 2.0 2.3 5.9 -0.2 1.2 -2.4 -2.4 -0.4 -0.9 -1.3
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.5 1.1 -0.7 -0.5 -0.3 -0.3 -0.9 -1.1 0.6
Age at first live birth 0.5 0.9 2.0 0.3 -0.9 1.4 1.4 -0.1 1.1 0.3
Pulse wave peak to peak time 1.3 1.6 4.1 -1.2 1.1 2.0 2.0 -0.4 -0.2 0.4
Health satisfaction 1.0 1.3 2.8 1.7 -0.6 1.0 1.0 0.4 1.7 -0.9
Shortness of breath walking on level ground 0.9 1.1 3.3 1.1 -0.8 0.9 0.8 1.1 1.8 0.1
Qualifications: College or University degree 0.3 1.1 2.6 0.3 -0.7 1.3 1.4 0.5 1.6 0.5
Eye problems/disorders: None of the above 0.2 0.3 1.4 0.1 0.2 0.3 0.4 -0.5 -0.0 1.2
Mouth/teeth dental problems: Loose teeth 1.5 1.7 6.5 1.3 -0.9 -1.3 -1.2 -0.2 0.2 -2.5
Emphysema/chronic bronchitis 1.9 2.2 5.1 2.1 -1.6 0.2 0.2 0.6 1.5 -2.3
Medication for pain relief, constipation, heartburn 0.6 1.0 2.1 -1.0 0.0 1.5 1.4 -0.1 0.3 1.5
Neck or shoulder pain in last month 1.6 2.3 8.8 -0.6 -1.8 0.8 0.8 -1.2 -1.0 -3.0
Medication: Blood pressure 0.8 1.4 4.2 0.3 -0.8 -2.0 -2.1 0.8 -0.4 -0.2
Angina (self-reported) 1.0 1.3 3.2 1.1 0.2 -1.8 -1.8 -0.2 -0.4 -1.1
Migraine (self-reported) 1.2 1.5 4.1 -1.3 2.0 -0.8 -0.7 -0.8 -0.7 -1.5
Medication: Ibuprofen 0.8 0.9 2.5 1.6 -0.8 0.5 0.5 0.4 1.6 -0.5
Medication: Allopurinol 0.8 1.0 3.6 1.0 -0.6 -0.7 -0.7 -1.9 0.3 -0.9
Medication: Omeprazole 1.1 1.3 3.2 1.3 0.2 1.1 1.1 0.9 1.1 -1.8
Medication: Seretide 50 evohaler 0.2 0.2 0.7 -0.2 0.6 0.0 0.0 -0.3 -0.6 -0.8
Mean time to correctly identify matches 0.2 0.4 1.4 1.2 0.8 -0.6 -0.5 0.1 -0.2 0.1
Heart disease (mother) 2.3 2.8 6.1 1.7 -1.5 -2.5 -2.5 1.1 0.9 0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.4 1.8 -0.4 -0.2 0.4 0.5 -0.3 -0.3 1.4
Whole body fat mass 0.4 1.8 4.8 0.7 0.4 2.2 2.2 -1.2 0.5 -0.9
Leg fat mass (right) 0.6 2.3 4.8 -0.1 0.6 2.0 2.1 -2.2 -0.4 -1.6
Arm predicted mass (right) 1.2 6.1 16.2 -0.4 -0.1 4.0 4.0 -2.8 0.7 1.4
Pulse rate, automated reading 0.3 0.8 1.3 -0.8 -1.0 -1.0 -1.0 -0.9 -0.3 -1.1
Alcohol intake frequency. 1.1 2.5 4.8 0.8 -0.4 1.7 1.7 1.4 2.0 2.2
Comparative height size at age 10 0.9 5.0 14.4 -0.3 -1.4 3.8 3.8 -0.7 0.7 1.8
Number of full sisters 0.6 0.8 1.5 0.9 -0.0 1.2 1.2 -0.3 1.0 0.9
Suffer from ‘nerves’ 2.3 3.6 22.8 -0.9 0.4 -0.2 -0.3 -0.5 -1.0 -4.8
Overall health rating 1.8 3.8 22.8 -0.1 0.2 0.0 0.1 -1.7 -0.8 -4.8
Chest pain or discomfort 1.9 2.7 10.7 2.1 -1.2 -0.2 -0.1 0.5 1.4 -3.3
Had major operations 0.9 1.1 6.4 0.0 0.8 -0.2 -0.2 -0.8 0.2 -2.5
Age at last live birth 0.9 1.2 2.7 0.7 -1.0 1.6 1.6 0.3 1.3 0.5
Family relationship satisfaction 0.3 0.4 1.5 -0.5 -0.1 0.7 0.7 0.1 0.5 -1.2
Leg pain on walking 0.2 0.3 0.9 0.5 0.4 0.3 0.2 -0.8 0.2 -1.0
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 1.8 -0.3 -0.3 0.8 0.7 -1.3 -0.2 -0.6
Commuting to job workplace: Car/motor vehicle 1.2 1.4 4.4 -1.7 0.6 -0.0 -0.1 -1.1 -2.1 0.7
Illness, injury, bereavement, stress in last 2 years 1.0 1.2 4.0 0.2 -0.5 -0.1 -0.1 1.9 0.7 2.0
Medication: Aspirin 1.1 1.4 3.0 1.4 1.0 -1.4 -1.5 0.0 0.0 -1.7
Supplements: Vitamin C 1.0 1.2 5.0 0.7 -1.3 0.4 0.4 0.5 0.7 2.2
Knee pain experienced in last month 0.9 1.4 3.3 0.7 0.5 1.8 1.8 -0.6 0.5 -1.4
Hypertension (Self-reported) 0.8 2.2 4.2 1.3 -2.0 -2.0 -2.0 0.9 -0.2 -0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 1.8 0.1 0.6 -1.3 -1.3 0.6 -0.3 0.1
Illnesses of father: Heart disease 0.8 1.1 2.2 1.0 -1.0 -1.5 -1.5 1.0 -0.3 -0.1
Illnesses of siblings: Diabetes 0.3 0.3 0.6 -0.3 -0.8 -0.4 -0.4 -0.6 -0.8 -0.5
Smoking status: Previous 0.3 0.5 1.2 -1.1 0.6 0.4 0.3 -0.9 -0.6 -0.7
Forced expiratory volume in 1-second (FEV1), predicted 1.3 2.6 5.6 0.8 0.1 2.3 2.4 1.1 1.6 1.8
Whole body fat-free mass 1.5 8.3 23.8 -0.0 -0.5 4.8 4.9 -2.2 1.4 2.0
Leg fat-free mass (right) 1.0 5.3 13.5 0.4 -1.4 3.6 3.7 -1.5 1.5 1.9
Arm fat percentage (left) 0.3 1.4 3.8 1.0 0.3 1.3 1.3 -0.8 0.5 -2.0
Average weekly red wine intake 0.8 1.1 3.1 1.7 0.1 -0.9 -0.8 1.1 1.5 0.4
Handedness (chirality/laterality): Left-handed 0.2 0.2 0.8 -0.6 -0.9 -0.3 -0.4 0.6 0.1 0.0
Mood swings 1.2 2.1 9.4 0.3 -0.8 -1.3 -1.3 -1.2 -0.1 -3.1
Loneliness, isolation 1.5 2.1 9.1 -1.7 0.4 0.7 0.7 -1.1 -0.6 -3.0
Long-standing illness, disability or infirmity 0.3 0.5 1.2 0.4 0.2 0.6 0.5 -0.9 0.7 -1.1
Ever had bowel cancer screening 0.5 0.6 1.3 1.1 -0.3 -1.0 -1.0 1.0 0.3 0.2
Diabetes diagnosed by doctor 1.0 1.7 4.0 -0.2 -1.2 -2.0 -2.0 -1.1 -0.4 -0.9
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.5 0.8 -0.3 0.0 0.8 0.8 -0.9 -0.7 -0.8
Friendships satisfaction 0.9 1.1 5.9 0.8 -0.6 -0.6 -0.6 0.3 0.4 -2.4
Qualifications: nursing, teaching 0.3 0.5 1.0 -0.6 0.8 0.9 1.0 -0.6 -0.1 0.6
Commuting to job workplace: Walk 1.2 1.3 2.2 -0.5 1.4 -1.5 -1.5 -1.1 -0.7 -0.5
Eye problems/disorders: Cataract 0.3 0.4 0.7 0.1 0.3 0.8 0.8 0.6 0.8 -0.6
Mouth/teeth dental problems: Mouth ulcers 0.8 1.2 2.7 1.4 0.0 0.6 0.6 1.2 1.6 -1.5
Medication for cholesterol 1.1 1.7 4.0 -1.2 1.1 1.9 2.0 -0.8 -0.6 0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.1 2.4 6.5 1.1 -0.7 -2.5 -2.6 1.5 -0.1 0.1
Back pain experienced in last month 2.8 4.1 10.9 -0.2 -1.0 -2.1 -2.1 -1.9 -2.1 -3.3
Mineral and other dietary supplements 0.6 0.9 4.2 0.1 1.1 0.1 0.1 0.6 -0.3 -2.0
Breast cancer (self-reported) 0.5 0.5 3.2 0.1 1.8 0.5 0.5 0.3 0.3 0.1
Asthma (self-reported) 0.8 1.6 5.6 1.2 -0.2 -0.8 -0.8 2.4 1.6 0.1
Osteoporosis (self-reported) 1.0 1.3 3.9 0.4 -1.7 0.2 0.2 0.7 1.1 2.0
Osteoarthritis (self-reported) 1.1 1.4 3.8 -0.8 -0.7 1.2 1.2 -1.9 -1.1 0.8
Medication: Aspirin 0.9 1.2 3.3 1.6 0.2 -1.0 -1.0 -0.1 0.5 -1.8
Medication: Gliclazide 1.5 1.7 4.6 -0.4 -0.6 -2.1 -2.1 -1.3 -0.8 0.4
Illnesses of father: None of the above (group 1) 1.4 1.7 3.3 0.1 1.0 1.4 1.4 1.8 0.9 1.7
Smoking status: Current 3.6 5.7 27.6 -1.3 1.2 -0.5 -0.4 -1.7 -2.4 -5.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.6 2.1 -0.4 1.4 1.1 1.0 -0.2 -0.2 0.0
Whole body water mass 1.4 8.0 23.0 -0.0 -0.5 4.7 4.8 -2.3 1.4 1.8
Leg predicted mass (right) 0.9 5.1 12.8 0.4 -1.3 3.5 3.6 -1.5 1.5 1.9
Arm fat mass (left) 0.6 2.3 6.1 0.6 0.5 2.5 2.5 -1.5 0.6 -0.9
Number of self-reported non-cancer illnesses 1.6 2.7 8.3 0.3 -0.4 -2.8 -2.9 -0.2 -0.9 -1.2
Average weekly champagne plus white wine intake 0.2 0.2 0.8 -0.7 0.0 0.3 0.2 -0.4 0.2 0.9
Miserableness 1.6 2.8 13.6 0.0 -0.9 -1.5 -1.5 -0.5 0.1 -3.7
Guilty feelings 2.2 3.3 18.2 -0.6 0.6 -1.1 -1.1 -1.1 -0.9 -4.3
Wears glasses or contact lenses 0.9 1.0 3.5 -1.8 0.4 -0.1 -0.2 0.1 -1.9 0.0
Ever taken oral contraceptive pill 0.9 1.0 4.3 0.9 -1.0 0.1 0.1 -0.7 0.3 -2.1
Hearing aid user 1.3 1.5 3.3 1.3 -0.4 1.8 1.8 -0.7 0.6 -0.9
Mother’s age at death 0.7 0.9 2.2 -0.6 -0.4 -1.0 -1.1 -1.5 -0.7 -0.9
Financial situation satisfaction 0.7 0.9 2.0 1.2 -0.4 -0.7 -0.7 -0.5 1.2 -1.4
Tinnitus: Yes, now most or all of the time 1.5 1.8 4.7 -0.1 1.1 -2.2 -2.1 -0.4 -1.2 -0.1
Commuting to job workplace: Public transport 0.5 0.6 1.6 1.3 -0.6 0.1 0.1 0.8 1.2 0.2
Eye problems/disorders: Glaucoma 0.7 0.8 4.2 -0.5 -2.0 0.2 0.1 -0.6 -0.7 0.8
Medication: Blood pressure 0.4 0.8 2.2 0.6 -0.6 -1.4 -1.5 0.7 0.2 0.1
Pain type(s) experienced in last month: Hip pain 0.6 0.7 2.9 0.8 0.7 0.0 0.0 -1.1 0.2 -1.7
Supplements: Fish oil (including cod liver oil) 1.2 1.6 4.0 -0.2 -0.6 -1.7 -1.7 -1.0 -0.0 2.0
High cholesterol (Self-reported) 0.3 0.5 1.2 1.0 -0.3 -1.1 -1.1 0.2 0.2 -0.5
Medication: Bendroflumethiazide 1.1 1.7 5.1 -0.3 -1.0 -2.2 -2.3 0.7 -0.6 0.1
Medication: Paracetamol 0.7 1.1 2.6 -1.3 1.6 0.9 0.9 -1.1 -0.8 -0.0
Medication: Lisinopril 1.6 2.1 5.0 0.7 -1.1 -2.2 -2.2 1.5 -0.2 0.9
Medication: Atorvastatin 0.3 0.3 1.2 0.8 0.6 0.2 0.2 -1.1 0.4 0.0
Illnesses of father: High blood pressure 1.1 1.4 2.7 -1.6 0.8 -0.8 -0.8 -1.2 -1.6 -1.1
Alcohol drinker status: Never 0.3 0.4 1.2 -0.5 -0.2 0.6 0.6 -0.5 1.1 0.1
Ever smoked 2.0 3.5 18.1 -1.0 0.2 -0.6 -0.6 -1.7 -1.3 -4.3
Basal metabolic rate 1.3 7.4 21.5 0.2 -0.4 4.6 4.6 -2.1 1.4 1.7
Leg fat percentage (left) 0.5 1.7 6.3 0.0 0.9 0.7 0.7 -1.7 -1.0 -2.5
Arm fat-free mass (left) 1.5 7.7 23.3 -0.2 0.2 4.8 4.8 -2.4 1.0 0.9
Number of operations (self-reported) 0.9 1.3 7.8 0.2 0.6 0.6 0.6 0.4 0.0 -2.8
Average weekly beer plus cider intake 0.7 1.1 1.8 -0.7 -0.6 -1.3 -1.3 -0.9 -1.4 -0.8
Irritability 0.9 1.6 9.4 0.1 0.8 -0.5 -0.6 0.4 0.2 -3.1
Risk taking 0.7 1.1 5.3 0.2 -0.4 1.0 1.0 0.1 -0.1 -2.3
Ever had prostate specific antigen (PSA) test 1.1 1.3 3.0 -0.0 1.7 -1.3 -1.3 -0.3 -1.4 0.8
Fractured/broken bones in last 5 years 0.5 0.6 1.6 -0.9 1.3 0.2 0.1 -0.9 -0.3 -0.9
Age started oral contraceptive pill 0.7 0.9 3.3 1.2 -0.5 0.1 0.2 0.3 1.8 1.1
Diastolic blood pressure, automated reading 1.1 3.3 9.2 -0.0 -3.0 -2.5 -2.5 0.5 -1.0 0.5
Ever depressed for a whole week 2.2 2.8 7.2 -0.2 -0.1 -2.7 -2.7 -0.4 -0.8 -2.0
Unable to work because of sickness or disability 0.2 0.2 0.5 -0.4 0.7 -0.3 -0.4 -0.2 -0.3 -0.7
Commuting to job workplace: Cycle 1.3 1.5 4.5 1.3 -0.6 1.2 1.3 0.6 2.1 0.9
Myopia 0.3 0.4 1.0 -0.9 0.0 -1.0 -1.0 0.6 -0.2 0.1
Vascular/heart problems diagnosed by doctor 0.6 1.5 3.7 -1.3 1.9 1.4 1.5 -0.9 -0.1 0.4
Cholesterol lowering medication 0.6 0.9 3.1 1.8 -0.2 -0.6 -0.7 1.2 0.9 -0.3
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 2.4 0.7 0.4 0.6 0.5 0.3 0.2 -1.5
Pain experienced in last month 0.7 1.2 4.8 -0.2 0.2 0.4 0.3 1.4 1.1 2.2
Supplements: Calcium 1.1 1.2 3.6 0.5 -0.9 0.2 0.2 1.7 0.9 1.9
Basal cell carcinoma (self-reported) 1.4 1.7 5.2 2.3 1.2 0.3 0.3 1.4 1.5 1.0
Heart attack/myocardial infarction (self-reported) 0.3 0.4 1.4 1.2 0.1 -0.5 -0.4 0.3 0.7 -0.6
Deep venous thrombosis (DVT) (self-reported) 2.1 2.7 8.1 0.5 -0.1 2.8 2.8 -0.6 0.5 -1.4
Heart disease (siblings) 0.5 0.6 1.5 -0.4 0.0 -0.8 -0.9 -1.1 -1.2 -0.4
Alcohol drinker status: Previous 0.6 0.7 2.1 0.8 -1.4 -0.4 -0.4 1.2 0.2 -0.2
Pack years of smoking 0.4 0.6 0.9 0.7 0.6 0.9 0.9 -0.9 0.5 -0.9
Impedance of whole body 0.4 2.1 7.8 0.1 1.3 -1.5 -1.6 2.8 0.0 0.6
Leg fat mass (left) 0.4 1.6 3.6 0.1 0.4 1.7 1.7 -1.9 -0.2 -1.3
Arm predicted mass (left) 1.4 7.1 21.3 0.0 -0.0 4.5 4.6 -2.2 1.1 1.2