[Hub]/) : Traits : High blood pressure :

chr16:29,412,503-31,860,399

Best TWAS P=7.06e-10 · Best GWAS P=3.16e-09 conditioned to 0.065

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex DOC2A 0.08 0.01 bslmm 213 0.05 2.4e-06 -4.4 -5.2 1.9e-07 0.13 0.07 0.91 FALSE
2 CommonMind Brain Pre-frontal Cortex KAT8 0.06 0.07 lasso 1 0.07 3.9e-09 -5.7 5.7 9.7e-09 -0.69 0.02 0.98 FALSE
3 CommonMind Brain Pre-frontal Cortex VKORC1 0.03 0.04 lasso 3 0.03 4.9e-05 -5.9 -6.0 2.2e-09 0.97 0.01 0.97 FALSE
4 CommonMind Brain Pre-frontal Cortex ZNF646 0.04 0.06 lasso 7 0.04 4.5e-06 -5.4 5.7 1.0e-08 -0.70 0.08 0.92 FALSE
5 GTEx Adipose Subcutaneous KAT8 0.19 0.17 lasso 5 0.25 4.8e-20 4.2 5.3 9.2e-08 -0.54 0.69 0.31 FALSE
6 GTEx Adipose Visceral Omentum KAT8 0.07 0.02 lasso 5 0.02 4.0e-02 -5.8 5.6 2.1e-08 -0.65 0.02 0.94 FALSE
7 GTEx Adrenal Gland KAT8 0.11 0.06 enet 11 0.07 1.8e-03 -5.6 5.3 1.2e-07 -0.67 0.04 0.84 FALSE
8 GTEx Artery Aorta KAT8 0.23 0.20 lasso 4 0.20 2.7e-11 -5.8 6.0 2.2e-09 -0.66 0.02 0.98 FALSE
9 GTEx Artery Coronary KAT8 0.22 0.19 lasso 2 0.19 6.6e-07 -5.8 5.9 4.5e-09 -0.68 0.02 0.96 FALSE
10 GTEx Artery Tibial KAT8 0.30 0.23 lasso 5 0.27 3.3e-21 4.2 5.6 2.2e-08 -0.56 0.50 0.50 FALSE
11 GTEx Brain Cerebellar Hemisphere KAT8 0.12 0.23 lasso 3 0.18 2.9e-05 -5.8 5.9 4.8e-09 -0.72 0.02 0.91 FALSE
12 GTEx Brain Cerebellum KAT8 0.21 0.01 lasso 9 0.05 1.4e-02 -5.8 6.2 7.1e-10 -0.58 0.03 0.87 TRUE
13 GTEx Brain Cortex KAT8 0.14 0.14 lasso 3 0.10 8.9e-04 -4.9 5.5 3.8e-08 -0.78 0.04 0.80 FALSE
14 GTEx Brain Frontal Cortex BA9 KAT8 0.16 0.20 lasso 1 0.17 2.6e-05 -5.8 5.8 8.9e-09 -0.70 0.02 0.92 FALSE
15 GTEx Brain Nucleus accumbens basal ganglia KAT8 0.19 0.13 lasso 4 0.18 1.4e-05 -5.8 5.8 6.8e-09 -0.59 0.02 0.86 FALSE
16 GTEx Breast Mammary Tissue KAT8 0.23 0.14 lasso 10 0.17 4.4e-09 -5.8 5.7 1.1e-08 -0.61 0.02 0.98 FALSE
17 GTEx Colon Sigmoid KAT8 0.20 0.10 lasso 3 0.14 1.0e-05 -5.8 5.8 7.1e-09 -0.59 0.03 0.91 FALSE
18 GTEx Colon Transverse KAT8 0.14 0.12 lasso 6 0.05 1.4e-03 4.2 5.1 2.7e-07 -0.40 0.15 0.59 FALSE
19 GTEx Esophagus Gastroesophageal Junction KAT8 0.18 0.11 lasso 4 0.24 4.9e-09 4.2 5.6 2.4e-08 -0.60 0.08 0.91 FALSE
20 GTEx Esophagus Mucosa BCKDK 0.05 0.05 enet 6 0.06 8.7e-05 -5.4 -5.3 1.0e-07 0.78 0.04 0.92 FALSE
21 GTEx Esophagus Mucosa KAT8 0.21 0.15 lasso 4 0.23 3.5e-15 4.2 5.7 1.1e-08 -0.57 0.10 0.90 FALSE
22 GTEx Esophagus Muscularis KAT8 0.29 0.19 lasso 4 0.21 1.2e-12 4.2 5.5 4.0e-08 -0.52 0.26 0.74 FALSE
23 GTEx Esophagus Muscularis INO80E 0.10 0.11 enet 20 0.07 4.6e-05 5.0 -5.2 2.3e-07 0.18 0.02 0.98 FALSE
24 GTEx Liver PRSS53 0.22 0.08 lasso 5 0.11 5.5e-04 -5.6 5.7 9.4e-09 -0.71 0.04 0.84 FALSE
25 GTEx Liver VKORC1 0.22 0.20 lasso 5 0.22 1.1e-06 -5.4 5.6 2.8e-08 -0.72 0.03 0.96 FALSE
26 GTEx Lung KAT8 0.14 0.08 lasso 3 0.12 1.7e-09 -5.8 6.0 2.1e-09 -0.60 0.03 0.97 FALSE
27 GTEx Nerve Tibial KAT8 0.17 0.06 enet 24 0.08 3.0e-06 4.2 5.9 4.5e-09 -0.61 0.02 0.97 FALSE
28 GTEx Ovary KAT8 0.16 0.09 lasso 4 0.06 1.2e-02 -5.8 5.9 2.7e-09 -0.65 0.03 0.82 FALSE
29 GTEx Prostate KAT8 0.19 0.09 lasso 3 0.13 3.8e-04 -5.8 6.1 1.0e-09 -0.73 0.03 0.72 FALSE
30 GTEx Skin Not Sun Exposed Suprapubic KAT8 0.30 0.20 enet 15 0.26 1.9e-14 4.2 5.8 7.3e-09 -0.60 0.05 0.95 FALSE
31 GTEx Skin Sun Exposed Lower leg KAT8 0.31 0.23 lasso 6 0.35 2.2e-30 -5.8 5.7 1.1e-08 -0.59 0.02 0.98 FALSE
32 GTEx Stomach KAT8 0.12 0.03 lasso 5 0.07 2.9e-04 4.2 5.6 1.7e-08 -0.58 0.06 0.91 FALSE
33 GTEx Thyroid KAT8 0.21 0.12 lasso 6 0.15 2.2e-11 -5.8 5.9 4.4e-09 -0.64 0.02 0.98 FALSE
34 GTEx Uterus FBRS 0.21 0.07 lasso 10 0.07 1.7e-02 -5.4 -5.2 2.5e-07 0.73 0.03 0.59 FALSE
35 GTEx Whole Blood HSD3B7 0.06 0.06 lasso 4 0.06 2.6e-06 -5.6 -5.8 8.8e-09 0.72 0.03 0.97 FALSE
36 GTEx Whole Blood ZNF668 0.05 0.06 lasso 3 0.06 5.9e-06 -5.8 -5.8 6.7e-09 0.66 0.02 0.98 FALSE
37 METSIM Adipose KAT8 0.17 0.13 lasso 6 0.20 1.7e-28 -5.8 5.6 1.7e-08 -0.58 0.02 0.98 FALSE
38 NTR Blood ZNF48 0.01 0.00 blup 196 0.00 2.2e-02 1.0 -5.8 5.1e-09 0.54 0.04 0.06 FALSE
39 ROSMAP Brain Pre-frontal Cortex KAT8 0.13 0.16 lasso 5 0.16 4.2e-20 -5.8 6.0 1.8e-09 -0.68 0.02 0.98 FALSE
40 ROSMAP Brain Pre-frontal Cortex ZNF668 0.11 0.11 lasso 4 0.11 1.7e-14 -5.4 -5.3 9.3e-08 0.68 0.05 0.95 FALSE
41 ROSMAP Brain Pre-frontal Cortex ZNF646 0.06 0.01 bslmm 233 0.01 1.1e-02 -5.5 5.3 1.4e-07 -0.64 0.04 0.95 FALSE
42 YFS Blood HSD3B7 0.06 0.02 blup 220 0.03 8.9e-10 -5.9 -5.4 7.6e-08 0.52 0.02 0.98 FALSE
43 YFS Blood PRSS36 0.02 0.02 enet 8 0.02 1.1e-07 4.2 5.2 1.7e-07 -0.35 0.92 0.04 FALSE
44 YFS Blood ZNF668 0.10 0.12 bslmm 232 0.12 1.5e-36 -5.4 -5.6 2.7e-08 0.69 0.07 0.93 FALSE
45 The Cancer Genome Atlas Bladder Urothelial Carcinoma MYST1 0.04 0.03 enet 4 0.03 1.2e-03 4.2 5.4 7.7e-08 -0.50 0.04 0.76 FALSE
46 The Cancer Genome Atlas Breast Invasive Carcinoma FAM57B 0.04 0.01 blup 46 0.03 2.6e-07 5.0 6.0 1.5e-09 -0.14 0.02 0.98 TRUE
47 The Cancer Genome Atlas Breast Invasive Carcinoma MYST1 0.05 0.04 blup 34 0.08 2.1e-15 4.2 5.2 1.6e-07 -0.54 0.41 0.59 FALSE
48 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma MYST1 0.26 0.01 blup 34 0.05 1.4e-03 -5.7 6.1 9.2e-10 -0.51 0.01 0.63 FALSE
49 The Cancer Genome Atlas Glioblastoma Multiforme MYST1 0.18 0.07 blup 35 0.11 4.2e-04 -5.4 5.2 2.4e-07 -0.68 0.02 0.90 FALSE
50 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma HSD3B7 0.06 0.01 blup 31 0.02 7.4e-04 3.5 5.4 6.9e-08 -0.60 0.05 0.76 FALSE
51 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma ZNF668 0.03 0.01 lasso 3 0.01 2.5e-02 -5.4 -5.5 4.8e-08 0.69 0.02 0.75 FALSE
52 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma DOC2A 0.03 0.01 blup 47 0.02 3.8e-03 4.1 -5.3 9.9e-08 0.12 0.02 0.59 FALSE
53 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma MYST1 0.12 0.09 blup 34 0.10 2.8e-11 4.2 5.3 1.1e-07 -0.51 0.83 0.17 FALSE
54 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma VKORC1 0.03 0.04 lasso 3 0.04 3.2e-05 -5.4 5.6 1.9e-08 -0.71 0.02 0.98 FALSE
55 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma ZNF668 0.02 0.02 blup 32 0.02 2.9e-03 -5.5 -5.7 9.6e-09 0.69 0.02 0.93 FALSE
56 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma MYST1 0.07 0.01 enet 6 0.04 1.6e-03 -5.9 5.2 2.4e-07 -0.60 0.01 0.88 FALSE
57 The Cancer Genome Atlas Brain Lower Grade Glioma C16orf93 0.09 0.09 blup 11 0.09 1.0e-10 4.0 -5.4 7.5e-08 0.51 0.83 0.15 FALSE
58 The Cancer Genome Atlas Brain Lower Grade Glioma INO80E 0.07 0.03 blup 48 0.03 1.1e-04 4.1 -5.2 1.5e-07 0.14 0.06 0.68 FALSE
59 The Cancer Genome Atlas Brain Lower Grade Glioma MYST1 0.16 0.08 blup 34 0.12 1.5e-13 -5.8 5.8 7.7e-09 -0.57 0.01 0.99 FALSE
60 The Cancer Genome Atlas Brain Lower Grade Glioma ZNF668 0.02 0.01 enet 8 0.02 3.1e-03 -5.4 -5.5 4.3e-08 0.67 0.02 0.83 FALSE
61 The Cancer Genome Atlas Liver Hepatocellular Carcinoma YPEL3 0.15 0.00 blup 20 0.05 2.9e-03 4.1 5.2 2.2e-07 -0.11 0.00 0.02 FALSE
62 The Cancer Genome Atlas Lung Adenocarcinoma MYST1 0.09 0.03 blup 33 0.03 1.4e-04 4.2 5.2 1.7e-07 -0.44 0.13 0.62 FALSE
63 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma MYST1 0.03 0.05 blup 34 0.03 2.1e-03 -5.4 5.7 1.2e-08 -0.69 0.02 0.92 FALSE
64 The Cancer Genome Atlas Pancreatic Adenocarcinoma MYST1 0.22 0.15 blup 36 0.21 2.1e-09 -5.9 5.3 1.2e-07 -0.59 0.01 0.99 FALSE
65 The Cancer Genome Atlas Prostate Adenocarcinoma MYST1 0.19 0.12 blup 33 0.18 1.5e-18 -5.8 5.6 2.0e-08 -0.60 0.01 0.99 FALSE
66 The Cancer Genome Atlas Rectum Adenocarcinoma MYST1 0.13 0.05 blup 35 0.06 1.9e-02 -5.9 5.9 3.1e-09 -0.66 0.01 0.63 FALSE
67 The Cancer Genome Atlas Stomach Adenocarcinoma MYST1 0.04 0.02 blup 35 0.02 8.7e-03 4.2 5.3 1.1e-07 -0.56 0.02 0.47 FALSE
68 The Cancer Genome Atlas Testicular Germ Cell Tumors MYST1 0.13 0.06 blup 34 0.12 6.8e-05 -5.7 6.1 1.1e-09 -0.65 0.02 0.95 FALSE
69 The Cancer Genome Atlas Thyroid Carcinoma DOC2A 0.03 0.02 blup 48 0.03 6.1e-04 5.0 -5.2 1.9e-07 0.14 0.02 0.84 FALSE
70 The Cancer Genome Atlas Thyroid Carcinoma MYST1 0.12 0.10 lasso 3 0.14 1.1e-13 -5.8 5.8 5.5e-09 -0.59 0.01 0.99 FALSE