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chr16:29,412,503-31,860,399

Best TWAS P=7.06e-10 · Best GWAS P=3.16e-09 conditioned to 0.065

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
12	GTEx	Brain Cerebellum	KAT8	0.21	0.01	lasso	9	0.05	1.4e-02	-5.8	6.2	7.1e-10	-0.58	0.03	0.87	TRUE
46	The Cancer Genome Atlas	Breast Invasive Carcinoma	FAM57B	0.04	0.01	blup	46	0.03	2.6e-07	5.0	6.0	1.5e-09	-0.14	0.02	0.98	TRUE
48	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	MYST1	0.26	0.01	blup	34	0.05	1.4e-03	-5.7	6.1	9.2e-10	-0.51	0.01	0.63	FALSE
29	GTEx	Prostate	KAT8	0.19	0.09	lasso	3	0.13	3.8e-04	-5.8	6.1	1.0e-09	-0.73	0.03	0.72	FALSE
68	The Cancer Genome Atlas	Testicular Germ Cell Tumors	MYST1	0.13	0.06	blup	34	0.12	6.8e-05	-5.7	6.1	1.1e-09	-0.65	0.02	0.95	FALSE
39	ROSMAP	Brain Pre-frontal Cortex	KAT8	0.13	0.16	lasso	5	0.16	4.2e-20	-5.8	6.0	1.8e-09	-0.68	0.02	0.98	FALSE
26	GTEx	Lung	KAT8	0.14	0.08	lasso	3	0.12	1.7e-09	-5.8	6.0	2.1e-09	-0.60	0.03	0.97	FALSE
3	CommonMind	Brain Pre-frontal Cortex	VKORC1	0.03	0.04	lasso	3	0.03	4.9e-05	-5.9	-6.0	2.2e-09	0.97	0.01	0.97	FALSE
8	GTEx	Artery Aorta	KAT8	0.23	0.20	lasso	4	0.20	2.7e-11	-5.8	6.0	2.2e-09	-0.66	0.02	0.98	FALSE
28	GTEx	Ovary	KAT8	0.16	0.09	lasso	4	0.06	1.2e-02	-5.8	5.9	2.7e-09	-0.65	0.03	0.82	FALSE
66	The Cancer Genome Atlas	Rectum Adenocarcinoma	MYST1	0.13	0.05	blup	35	0.06	1.9e-02	-5.9	5.9	3.1e-09	-0.66	0.01	0.63	FALSE
33	GTEx	Thyroid	KAT8	0.21	0.12	lasso	6	0.15	2.2e-11	-5.8	5.9	4.4e-09	-0.64	0.02	0.98	FALSE
9	GTEx	Artery Coronary	KAT8	0.22	0.19	lasso	2	0.19	6.6e-07	-5.8	5.9	4.5e-09	-0.68	0.02	0.96	FALSE
27	GTEx	Nerve Tibial	KAT8	0.17	0.06	enet	24	0.08	3.0e-06	4.2	5.9	4.5e-09	-0.61	0.02	0.97	FALSE
11	GTEx	Brain Cerebellar Hemisphere	KAT8	0.12	0.23	lasso	3	0.18	2.9e-05	-5.8	5.9	4.8e-09	-0.72	0.02	0.91	FALSE
38	NTR	Blood	ZNF48	0.01	0.00	blup	196	0.00	2.2e-02	1.0	-5.8	5.1e-09	0.54	0.04	0.06	FALSE
70	The Cancer Genome Atlas	Thyroid Carcinoma	MYST1	0.12	0.10	lasso	3	0.14	1.1e-13	-5.8	5.8	5.5e-09	-0.59	0.01	0.99	FALSE
36	GTEx	Whole Blood	ZNF668	0.05	0.06	lasso	3	0.06	5.9e-06	-5.8	-5.8	6.7e-09	0.66	0.02	0.98	FALSE
15	GTEx	Brain Nucleus accumbens basal ganglia	KAT8	0.19	0.13	lasso	4	0.18	1.4e-05	-5.8	5.8	6.8e-09	-0.59	0.02	0.86	FALSE
17	GTEx	Colon Sigmoid	KAT8	0.20	0.10	lasso	3	0.14	1.0e-05	-5.8	5.8	7.1e-09	-0.59	0.03	0.91	FALSE
30	GTEx	Skin Not Sun Exposed Suprapubic	KAT8	0.30	0.20	enet	15	0.26	1.9e-14	4.2	5.8	7.3e-09	-0.60	0.05	0.95	FALSE
59	The Cancer Genome Atlas	Brain Lower Grade Glioma	MYST1	0.16	0.08	blup	34	0.12	1.5e-13	-5.8	5.8	7.7e-09	-0.57	0.01	0.99	FALSE
35	GTEx	Whole Blood	HSD3B7	0.06	0.06	lasso	4	0.06	2.6e-06	-5.6	-5.8	8.8e-09	0.72	0.03	0.97	FALSE
14	GTEx	Brain Frontal Cortex BA9	KAT8	0.16	0.20	lasso	1	0.17	2.6e-05	-5.8	5.8	8.9e-09	-0.70	0.02	0.92	FALSE
24	GTEx	Liver	PRSS53	0.22	0.08	lasso	5	0.11	5.5e-04	-5.6	5.7	9.4e-09	-0.71	0.04	0.84	FALSE
55	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ZNF668	0.02	0.02	blup	32	0.02	2.9e-03	-5.5	-5.7	9.6e-09	0.69	0.02	0.93	FALSE
2	CommonMind	Brain Pre-frontal Cortex	KAT8	0.06	0.07	lasso	1	0.07	3.9e-09	-5.7	5.7	9.7e-09	-0.69	0.02	0.98	FALSE
4	CommonMind	Brain Pre-frontal Cortex	ZNF646	0.04	0.06	lasso	7	0.04	4.5e-06	-5.4	5.7	1.0e-08	-0.70	0.08	0.92	FALSE
16	GTEx	Breast Mammary Tissue	KAT8	0.23	0.14	lasso	10	0.17	4.4e-09	-5.8	5.7	1.1e-08	-0.61	0.02	0.98	FALSE
21	GTEx	Esophagus Mucosa	KAT8	0.21	0.15	lasso	4	0.23	3.5e-15	4.2	5.7	1.1e-08	-0.57	0.10	0.90	FALSE
31	GTEx	Skin Sun Exposed Lower leg	KAT8	0.31	0.23	lasso	6	0.35	2.2e-30	-5.8	5.7	1.1e-08	-0.59	0.02	0.98	FALSE
63	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	MYST1	0.03	0.05	blup	34	0.03	2.1e-03	-5.4	5.7	1.2e-08	-0.69	0.02	0.92	FALSE
32	GTEx	Stomach	KAT8	0.12	0.03	lasso	5	0.07	2.9e-04	4.2	5.6	1.7e-08	-0.58	0.06	0.91	FALSE
37	METSIM	Adipose	KAT8	0.17	0.13	lasso	6	0.20	1.7e-28	-5.8	5.6	1.7e-08	-0.58	0.02	0.98	FALSE
54	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	VKORC1	0.03	0.04	lasso	3	0.04	3.2e-05	-5.4	5.6	1.9e-08	-0.71	0.02	0.98	FALSE
65	The Cancer Genome Atlas	Prostate Adenocarcinoma	MYST1	0.19	0.12	blup	33	0.18	1.5e-18	-5.8	5.6	2.0e-08	-0.60	0.01	0.99	FALSE
6	GTEx	Adipose Visceral Omentum	KAT8	0.07	0.02	lasso	5	0.02	4.0e-02	-5.8	5.6	2.1e-08	-0.65	0.02	0.94	FALSE
10	GTEx	Artery Tibial	KAT8	0.30	0.23	lasso	5	0.27	3.3e-21	4.2	5.6	2.2e-08	-0.56	0.50	0.50	FALSE
19	GTEx	Esophagus Gastroesophageal Junction	KAT8	0.18	0.11	lasso	4	0.24	4.9e-09	4.2	5.6	2.4e-08	-0.60	0.08	0.91	FALSE
44	YFS	Blood	ZNF668	0.10	0.12	bslmm	232	0.12	1.5e-36	-5.4	-5.6	2.7e-08	0.69	0.07	0.93	FALSE
25	GTEx	Liver	VKORC1	0.22	0.20	lasso	5	0.22	1.1e-06	-5.4	5.6	2.8e-08	-0.72	0.03	0.96	FALSE
13	GTEx	Brain Cortex	KAT8	0.14	0.14	lasso	3	0.10	8.9e-04	-4.9	5.5	3.8e-08	-0.78	0.04	0.80	FALSE
22	GTEx	Esophagus Muscularis	KAT8	0.29	0.19	lasso	4	0.21	1.2e-12	4.2	5.5	4.0e-08	-0.52	0.26	0.74	FALSE
60	The Cancer Genome Atlas	Brain Lower Grade Glioma	ZNF668	0.02	0.01	enet	8	0.02	3.1e-03	-5.4	-5.5	4.3e-08	0.67	0.02	0.83	FALSE
51	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ZNF668	0.03	0.01	lasso	3	0.01	2.5e-02	-5.4	-5.5	4.8e-08	0.69	0.02	0.75	FALSE
50	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	HSD3B7	0.06	0.01	blup	31	0.02	7.4e-04	3.5	5.4	6.9e-08	-0.60	0.05	0.76	FALSE
57	The Cancer Genome Atlas	Brain Lower Grade Glioma	C16orf93	0.09	0.09	blup	11	0.09	1.0e-10	4.0	-5.4	7.5e-08	0.51	0.83	0.15	FALSE
42	YFS	Blood	HSD3B7	0.06	0.02	blup	220	0.03	8.9e-10	-5.9	-5.4	7.6e-08	0.52	0.02	0.98	FALSE
45	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	MYST1	0.04	0.03	enet	4	0.03	1.2e-03	4.2	5.4	7.7e-08	-0.50	0.04	0.76	FALSE
5	GTEx	Adipose Subcutaneous	KAT8	0.19	0.17	lasso	5	0.25	4.8e-20	4.2	5.3	9.2e-08	-0.54	0.69	0.31	FALSE
40	ROSMAP	Brain Pre-frontal Cortex	ZNF668	0.11	0.11	lasso	4	0.11	1.7e-14	-5.4	-5.3	9.3e-08	0.68	0.05	0.95	FALSE
52	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DOC2A	0.03	0.01	blup	47	0.02	3.8e-03	4.1	-5.3	9.9e-08	0.12	0.02	0.59	FALSE
20	GTEx	Esophagus Mucosa	BCKDK	0.05	0.05	enet	6	0.06	8.7e-05	-5.4	-5.3	1.0e-07	0.78	0.04	0.92	FALSE
53	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MYST1	0.12	0.09	blup	34	0.10	2.8e-11	4.2	5.3	1.1e-07	-0.51	0.83	0.17	FALSE
67	The Cancer Genome Atlas	Stomach Adenocarcinoma	MYST1	0.04	0.02	blup	35	0.02	8.7e-03	4.2	5.3	1.1e-07	-0.56	0.02	0.47	FALSE
7	GTEx	Adrenal Gland	KAT8	0.11	0.06	enet	11	0.07	1.8e-03	-5.6	5.3	1.2e-07	-0.67	0.04	0.84	FALSE
64	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	MYST1	0.22	0.15	blup	36	0.21	2.1e-09	-5.9	5.3	1.2e-07	-0.59	0.01	0.99	FALSE
41	ROSMAP	Brain Pre-frontal Cortex	ZNF646	0.06	0.01	bslmm	233	0.01	1.1e-02	-5.5	5.3	1.4e-07	-0.64	0.04	0.95	FALSE
58	The Cancer Genome Atlas	Brain Lower Grade Glioma	INO80E	0.07	0.03	blup	48	0.03	1.1e-04	4.1	-5.2	1.5e-07	0.14	0.06	0.68	FALSE
47	The Cancer Genome Atlas	Breast Invasive Carcinoma	MYST1	0.05	0.04	blup	34	0.08	2.1e-15	4.2	5.2	1.6e-07	-0.54	0.41	0.59	FALSE
43	YFS	Blood	PRSS36	0.02	0.02	enet	8	0.02	1.1e-07	4.2	5.2	1.7e-07	-0.35	0.92	0.04	FALSE
62	The Cancer Genome Atlas	Lung Adenocarcinoma	MYST1	0.09	0.03	blup	33	0.03	1.4e-04	4.2	5.2	1.7e-07	-0.44	0.13	0.62	FALSE
1	CommonMind	Brain Pre-frontal Cortex	DOC2A	0.08	0.01	bslmm	213	0.05	2.4e-06	-4.4	-5.2	1.9e-07	0.13	0.07	0.91	FALSE
69	The Cancer Genome Atlas	Thyroid Carcinoma	DOC2A	0.03	0.02	blup	48	0.03	6.1e-04	5.0	-5.2	1.9e-07	0.14	0.02	0.84	FALSE
61	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	YPEL3	0.15	0.00	blup	20	0.05	2.9e-03	4.1	5.2	2.2e-07	-0.11	0.00	0.02	FALSE
23	GTEx	Esophagus Muscularis	INO80E	0.10	0.11	enet	20	0.07	4.6e-05	5.0	-5.2	2.3e-07	0.18	0.02	0.98	FALSE
49	The Cancer Genome Atlas	Glioblastoma Multiforme	MYST1	0.18	0.07	blup	35	0.11	4.2e-04	-5.4	5.2	2.4e-07	-0.68	0.02	0.90	FALSE
56	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	MYST1	0.07	0.01	enet	6	0.04	1.6e-03	-5.9	5.2	2.4e-07	-0.60	0.01	0.88	FALSE
34	GTEx	Uterus	FBRS	0.21	0.07	lasso	10	0.07	1.7e-02	-5.4	-5.2	2.5e-07	0.73	0.03	0.59	FALSE
18	GTEx	Colon Transverse	KAT8	0.14	0.12	lasso	6	0.05	1.4e-03	4.2	5.1	2.7e-07	-0.40	0.15	0.59	FALSE