[Hub]/) : Traits : BMI : ← →

chr11:45,945,837-48,559,571

Best TWAS P=6.83e-42 · Best GWAS P=9.3e-40 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	C11orf49	0.40	0.19	bslmm	329	0.20	2.9e-23	-4.30	-5.6	1.8e-08	-0.34	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	FAM180B	0.07	0.08	lasso	3	0.08	9.1e-10	13.03	12.4	2.4e-35	0.95	0.02	0.98	FALSE
3	CommonMind	Brain Pre-frontal Cortex	MADD	0.32	0.17	bslmm	315	0.18	1.4e-21	-6.20	6.6	4.4e-11	0.19	1.00	0.00	FALSE
4	CommonMind	Brain Pre-frontal Cortex	MTCH2	0.03	0.00	bslmm	299	0.00	1.1e-01	2.40	7.8	6.0e-15	0.68	0.07	0.54	FALSE
5	GTEx	Adipose Subcutaneous	ACP2	0.08	0.03	enet	18	0.03	3.5e-03	-4.46	8.8	2.0e-18	0.73	0.08	0.78	FALSE
6	GTEx	Adipose Subcutaneous	C1QTNF4	0.16	0.22	lasso	4	0.22	2.5e-18	13.20	-12.8	1.2e-37	-0.98	0.00	1.00	FALSE
7	GTEx	Artery Aorta	C1QTNF4	0.09	0.10	lasso	1	0.08	3.2e-05	13.03	-13.0	8.8e-39	-1.00	0.00	0.99	FALSE
8	GTEx	Brain Cerebellar Hemisphere	MADD	0.44	0.14	lasso	7	0.21	4.0e-06	-4.46	7.7	1.3e-14	0.50	0.33	0.19	FALSE
9	GTEx	Brain Cerebellar Hemisphere	ACP2	0.29	0.05	enet	16	0.12	5.9e-04	-4.04	5.6	1.8e-08	0.44	0.09	0.10	FALSE
10	GTEx	Brain Cerebellar Hemisphere	RP11-750H9.5	0.17	0.25	lasso	6	0.21	3.5e-06	-6.48	6.5	9.3e-11	0.29	0.43	0.06	FALSE
11	GTEx	Brain Cerebellum	MADD	0.21	0.00	enet	13	0.11	3.3e-04	-5.00	10.1	4.5e-24	0.63	0.07	0.68	FALSE
12	GTEx	Brain Cortex	MTCH2	0.21	0.19	lasso	6	0.16	4.0e-05	11.30	10.0	1.0e-23	0.79	0.35	0.18	FALSE
13	GTEx	Brain Cortex	C1QTNF4	0.26	0.04	lasso	8	0.02	1.2e-01	-10.77	-11.3	8.5e-30	-0.80	0.02	0.58	FALSE
14	GTEx	Brain Putamen basal ganglia	CKAP5	0.25	0.07	lasso	3	0.14	4.4e-04	-5.21	-5.6	1.7e-08	-0.44	0.05	0.26	FALSE
15	GTEx	Breast Mammary Tissue	C1QTNF4	0.10	0.06	lasso	2	0.03	8.5e-03	10.71	-10.4	2.5e-25	-0.82	0.11	0.67	FALSE
16	GTEx	Breast Mammary Tissue (Female)	MADD	0.13	0.04	lasso	3	0.05	1.3e-02	10.51	11.0	4.6e-28	0.81	0.05	0.32	TRUE
17	GTEx	Cells Transformed fibroblasts	FNBP4	0.11	0.05	lasso	8	0.08	1.6e-06	-11.27	12.1	8.7e-34	0.88	0.04	0.96	FALSE
18	GTEx	Cells Transformed fibroblasts	MADD	0.19	0.00	enet	17	0.09	3.3e-07	-5.09	8.2	3.7e-16	0.30	0.53	0.04	FALSE
19	GTEx	Cells Transformed fibroblasts	PSMC3	0.07	0.00	enet	13	0.02	2.3e-02	-4.00	9.3	1.0e-20	0.83	0.03	0.77	FALSE
20	GTEx	Cells Transformed fibroblasts	C1QTNF4	0.13	0.11	enet	19	0.12	5.2e-09	11.64	-11.2	2.6e-29	-0.84	0.03	0.97	FALSE
21	GTEx	Cells Transformed fibroblasts	NDUFS3	0.08	0.01	lasso	2	0.01	3.3e-02	13.20	-12.6	2.6e-36	-0.98	0.00	0.98	FALSE
22	GTEx	Colon Transverse	C1QTNF4	0.07	0.02	lasso	6	0.03	2.0e-02	13.20	-12.6	3.4e-36	-0.96	0.01	0.96	FALSE
23	GTEx	Esophagus Mucosa	MADD	0.27	0.04	enet	18	0.12	4.1e-08	-4.31	8.8	8.7e-19	0.40	0.26	0.08	FALSE
24	GTEx	Esophagus Mucosa	ACP2	0.07	0.04	enet	11	0.04	6.2e-04	-4.89	5.2	2.6e-07	0.33	0.78	0.06	FALSE
25	GTEx	Esophagus Mucosa	C11orf49	0.19	0.05	enet	21	0.12	3.2e-08	-4.84	-6.6	4.0e-11	-0.29	0.79	0.01	FALSE
26	GTEx	Esophagus Mucosa	C1QTNF4	0.10	0.11	lasso	1	0.10	5.0e-07	13.03	-13.0	8.8e-39	-1.00	0.00	1.00	FALSE
27	GTEx	Esophagus Muscularis	MTCH2	0.09	0.04	lasso	6	0.02	1.8e-02	11.64	11.4	6.7e-30	0.78	0.26	0.53	FALSE
28	GTEx	Esophagus Muscularis	MADD	0.13	0.07	enet	8	0.11	2.0e-07	-6.20	6.2	4.1e-10	0.17	0.73	0.01	FALSE
29	GTEx	Esophagus Muscularis	C1QTNF4	0.10	0.05	enet	23	0.06	1.4e-04	13.20	-12.0	6.4e-33	-0.93	0.01	0.99	FALSE
30	GTEx	Heart Atrial Appendage	ACP2	0.10	0.12	enet	7	0.10	2.7e-05	-5.44	7.2	4.0e-13	0.49	0.32	0.08	FALSE
31	GTEx	Heart Atrial Appendage	C1QTNF4	0.26	0.14	lasso	9	0.17	3.9e-08	13.03	-12.7	9.7e-37	-0.95	0.02	0.98	FALSE
32	GTEx	Heart Left Ventricle	MADD	0.14	0.01	enet	17	0.05	7.0e-04	-5.20	10.4	3.6e-25	0.70	0.02	0.95	TRUE
33	GTEx	Heart Left Ventricle	C1QTNF4	0.10	0.11	lasso	1	0.09	1.1e-05	13.03	-13.0	8.8e-39	-1.00	0.00	0.99	FALSE
34	GTEx	Liver	PSMC3	0.15	0.09	lasso	4	0.07	5.9e-03	7.30	7.4	1.2e-13	0.59	0.09	0.10	FALSE
35	GTEx	Liver	C1QTNF4	0.25	0.14	enet	16	0.20	2.3e-06	13.03	-12.7	4.3e-37	-0.84	0.02	0.97	TRUE
36	GTEx	Lung	ACP2	0.04	0.03	lasso	2	0.04	4.3e-04	-4.59	5.3	1.0e-07	0.39	0.55	0.02	FALSE
37	GTEx	Lung	C1QTNF4	0.18	0.15	lasso	6	0.13	3.2e-10	10.56	-11.8	4.5e-32	-0.91	0.09	0.91	FALSE
38	GTEx	Muscle Skeletal	MTCH2	0.05	0.03	enet	15	0.04	1.5e-04	10.22	11.7	1.0e-31	0.84	0.05	0.94	FALSE
39	GTEx	Muscle Skeletal	C1QTNF4	0.09	0.14	lasso	3	0.13	9.9e-13	13.03	-12.9	3.4e-38	-0.98	0.00	1.00	FALSE
40	GTEx	Nerve Tibial	NR1H3	0.10	0.00	enet	24	0.08	4.7e-06	-3.62	-9.8	1.6e-22	-0.52	0.01	0.82	FALSE
41	GTEx	Nerve Tibial	CELF1	0.08	0.02	enet	15	0.06	4.3e-05	-10.28	6.8	8.7e-12	0.40	0.21	0.04	FALSE
42	GTEx	Nerve Tibial	SLC39A13	0.07	0.01	enet	14	0.02	7.6e-03	10.53	6.6	3.4e-11	0.70	0.13	0.34	FALSE
43	GTEx	Nerve Tibial	C1QTNF4	0.20	0.23	enet	12	0.23	1.7e-16	13.03	-12.3	5.7e-35	-0.96	0.00	1.00	FALSE
44	GTEx	Pituitary	MADD	0.42	0.32	lasso	6	0.39	8.9e-11	-6.19	10.2	1.2e-24	0.60	0.25	0.63	FALSE
45	GTEx	Skin Not Sun Exposed Suprapubic	C11orf49	0.09	0.00	enet	12	0.03	6.0e-03	5.06	-5.7	1.0e-08	-0.41	0.18	0.25	FALSE
46	GTEx	Skin Not Sun Exposed Suprapubic	C1QTNF4	0.32	0.18	enet	33	0.20	5.2e-11	13.03	-11.5	1.1e-30	-0.90	0.00	1.00	FALSE
47	GTEx	Skin Sun Exposed Lower leg	PSMC3	0.20	0.05	lasso	7	0.10	1.2e-08	-4.00	6.2	5.5e-10	0.68	0.69	0.29	FALSE
48	GTEx	Skin Sun Exposed Lower leg	C1QTNF4	0.25	0.22	lasso	12	0.23	4.2e-19	13.03	-12.9	2.8e-38	-0.95	0.00	1.00	FALSE
49	GTEx	Spleen	LRP4	0.15	0.14	lasso	5	0.12	6.5e-04	5.45	-5.4	5.4e-08	-0.23	0.17	0.05	FALSE
50	GTEx	Spleen	C1QTNF4	0.31	0.28	enet	29	0.34	1.8e-09	11.30	-12.5	9.6e-36	-0.89	0.08	0.92	FALSE
51	GTEx	Testis	MTCH2	0.17	0.16	lasso	3	0.16	1.0e-07	10.71	10.7	9.0e-27	0.83	0.52	0.48	FALSE
52	GTEx	Testis	C1QTNF4	0.14	0.12	lasso	4	0.11	1.6e-05	-11.27	-11.2	3.8e-29	-0.73	0.28	0.67	FALSE
53	GTEx	Thyroid	MADD	0.11	0.00	enet	13	0.01	6.1e-02	-2.68	6.8	1.2e-11	0.25	0.06	0.04	FALSE
54	GTEx	Thyroid	ACP2	0.19	0.14	lasso	4	0.12	3.0e-09	-5.00	5.5	3.7e-08	0.34	1.00	0.00	FALSE
55	GTEx	Thyroid	C11orf49	0.09	0.05	lasso	3	0.04	3.0e-04	5.45	-5.3	9.0e-08	-0.24	0.90	0.01	FALSE
56	GTEx	Uterus	C11orf49	0.24	0.24	lasso	13	0.24	1.3e-05	5.06	-5.2	2.1e-07	-0.24	0.14	0.08	FALSE
57	GTEx	Whole Blood	C1QTNF4	0.09	0.05	lasso	3	0.03	1.4e-03	11.33	-11.4	4.0e-30	-0.86	0.18	0.72	FALSE
58	METSIM	Adipose	ACP2	0.05	0.04	blup	302	0.06	1.7e-09	10.71	7.5	6.8e-14	0.67	0.36	0.64	FALSE
59	METSIM	Adipose	C1QTNF4	0.24	0.31	lasso	7	0.31	1.2e-46	11.47	-11.3	2.2e-29	-0.86	1.00	0.00	FALSE
60	METSIM	Adipose	MYBPC3	0.11	0.10	enet	26	0.11	1.0e-15	10.71	-9.4	7.9e-21	-0.81	0.33	0.67	TRUE
61	METSIM	Adipose	PSMC3	0.06	0.03	enet	28	0.04	2.3e-06	4.62	8.8	1.8e-18	0.79	0.03	0.96	FALSE
62	NTR	Blood	ACP2	0.01	0.00	enet	7	0.01	2.5e-03	-4.89	6.9	5.9e-12	0.44	0.43	0.11	FALSE
63	NTR	Blood	DDB2	0.01	0.00	lasso	7	0.01	2.2e-03	-4.56	5.3	1.4e-07	0.28	0.32	0.01	FALSE
64	NTR	Blood	MTCH2	0.02	0.04	lasso	1	0.04	1.3e-11	11.64	-11.6	2.6e-31	-0.88	0.89	0.11	FALSE
65	ROSMAP	Brain Pre-frontal Cortex	MTCH2	0.35	0.40	enet	9	0.40	4.7e-56	11.47	11.9	9.0e-33	0.91	1.00	0.00	FALSE
66	ROSMAP	Brain Pre-frontal Cortex	FNBP4	0.04	0.04	lasso	3	0.04	8.2e-06	-11.26	11.8	4.7e-32	0.69	0.95	0.05	FALSE
67	ROSMAP	Brain Pre-frontal Cortex	MADD	0.33	0.16	enet	23	0.23	1.9e-29	-6.20	5.2	1.7e-07	0.08	1.00	0.00	FALSE
68	ROSMAP	Brain Pre-frontal Cortex	ACP2	0.03	0.00	blup	295	0.02	1.5e-03	10.42	8.9	7.8e-19	0.72	0.06	0.87	FALSE
69	ROSMAP	Brain Pre-frontal Cortex	PSMC3	0.15	0.08	bslmm	285	0.10	5.1e-13	-1.71	6.8	7.2e-12	0.68	0.40	0.60	FALSE
70	ROSMAP	Brain Pre-frontal Cortex	C1QTNF4	0.05	0.06	blup	281	0.06	1.7e-08	10.52	-10.0	1.0e-23	-0.86	0.11	0.89	FALSE
71	ROSMAP	Brain Pre-frontal Cortex	ATG13	0.05	0.02	bslmm	266	0.03	1.3e-04	5.00	-6.0	1.4e-09	-0.26	0.06	0.86	FALSE
72	YFS	Blood	DDB2	0.02	0.00	bslmm	306	0.01	1.9e-04	-5.10	6.7	3.0e-11	0.20	0.24	0.05	FALSE
73	YFS	Blood	FNBP4	0.02	0.01	bslmm	301	0.01	8.9e-05	-9.98	11.7	9.8e-32	0.78	0.03	0.95	FALSE
74	YFS	Blood	NR1H3	0.34	0.15	enet	66	0.24	3.1e-76	-4.60	8.1	8.5e-16	0.56	1.00	0.00	FALSE
75	YFS	Blood	NUP160	0.02	0.01	blup	290	0.01	1.7e-04	11.32	6.9	5.0e-12	0.65	0.24	0.60	FALSE
76	YFS	Blood	PSMC3	0.02	0.01	blup	289	0.01	2.8e-05	13.20	9.6	5.8e-22	0.84	0.00	0.99	FALSE
77	YFS	Blood	PTPMT1	0.03	0.01	lasso	5	0.01	3.2e-04	-10.73	-8.3	7.4e-17	-0.67	0.27	0.61	FALSE
78	YFS	Blood	SPI1	0.65	0.18	enet	75	0.27	1.6e-87	10.44	-7.3	2.2e-13	-0.62	1.00	0.00	FALSE
79	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	C1QTNF4	0.06	0.07	lasso	2	0.06	4.9e-06	11.57	-12.3	1.0e-34	-0.93	0.01	0.99	FALSE
80	The Cancer Genome Atlas	Breast Invasive Carcinoma	ACP2	0.02	0.01	blup	44	0.02	2.7e-04	-5.00	8.4	4.2e-17	0.50	0.04	0.21	FALSE
81	The Cancer Genome Atlas	Breast Invasive Carcinoma	C1QTNF4	0.02	0.01	lasso	5	0.02	2.1e-04	-3.42	-8.8	1.4e-18	-0.74	0.01	0.83	FALSE
82	The Cancer Genome Atlas	Breast Invasive Carcinoma	MADD	0.11	0.03	enet	14	0.06	1.4e-11	-6.20	11.1	1.8e-28	0.56	0.04	0.96	FALSE
83	The Cancer Genome Atlas	Breast Invasive Carcinoma	MYBPC3	0.02	0.01	blup	43	0.01	3.4e-03	10.56	-9.5	2.9e-21	-0.74	0.01	0.97	FALSE
84	The Cancer Genome Atlas	Breast Invasive Carcinoma	NUP160	0.03	0.01	blup	44	0.01	1.9e-03	10.22	6.7	1.6e-11	0.58	0.02	0.32	FALSE
85	The Cancer Genome Atlas	Colon Adenocarcinoma	C1QTNF4	0.12	0.12	lasso	1	0.12	1.6e-07	13.03	-13.0	8.8e-39	-1.00	0.00	1.00	FALSE
86	The Cancer Genome Atlas	Colon Adenocarcinoma	KBTBD4	0.14	0.01	blup	13	0.02	1.6e-02	-10.73	10.3	5.9e-25	0.90	0.00	0.53	FALSE
87	The Cancer Genome Atlas	Colon Adenocarcinoma	NUP160	0.05	0.05	blup	44	0.05	7.7e-04	-11.27	12.3	7.5e-35	0.82	0.02	0.78	FALSE
88	The Cancer Genome Atlas	Colon Adenocarcinoma	PSMC3	0.09	0.05	blup	39	0.05	1.0e-03	-6.48	8.2	3.3e-16	0.55	0.02	0.81	FALSE
89	The Cancer Genome Atlas	Esophageal Carcinoma	C1QTNF4	0.39	0.33	blup	15	0.35	6.1e-12	13.03	-12.7	4.0e-37	-0.98	0.00	1.00	FALSE
90	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C1QTNF4	0.06	0.08	lasso	3	0.08	7.5e-09	11.47	-11.5	8.9e-31	-0.88	0.04	0.96	FALSE
91	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	FNBP4	0.10	0.03	blup	45	0.05	7.7e-06	11.32	6.8	7.8e-12	0.51	0.01	0.97	FALSE
92	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MYBPC3	0.05	0.03	blup	43	0.04	6.0e-05	8.04	-8.8	8.5e-19	-0.71	0.02	0.98	FALSE
93	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	NUP160	0.08	0.03	blup	42	0.04	6.7e-05	11.27	9.4	3.5e-21	0.71	0.02	0.93	FALSE
94	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C1QTNF4	0.12	0.14	enet	4	0.16	6.5e-18	11.47	-12.5	1.4e-35	-0.95	0.03	0.97	FALSE
95	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MADD	0.20	0.07	enet	9	0.08	2.4e-09	-6.20	8.6	8.8e-18	0.32	0.92	0.01	FALSE
96	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PSMC3	0.05	0.04	lasso	3	0.05	3.8e-06	4.62	7.7	1.3e-14	0.73	0.01	0.99	FALSE
97	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	C1QTNF4	0.13	0.16	lasso	1	0.16	3.1e-09	11.62	-11.6	3.3e-31	-0.88	0.15	0.85	FALSE
98	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PSMC3	0.07	0.07	enet	7	0.06	1.4e-04	10.53	10.7	1.7e-26	0.82	0.01	0.98	FALSE
99	The Cancer Genome Atlas	Brain Lower Grade Glioma	ACP2	0.09	0.04	enet	12	0.06	5.0e-07	-4.46	7.6	3.1e-14	0.56	0.60	0.38	FALSE
100	The Cancer Genome Atlas	Brain Lower Grade Glioma	MADD	0.08	0.01	lasso	5	0.05	3.1e-06	10.42	11.2	2.5e-29	0.62	0.01	0.94	FALSE
101	The Cancer Genome Atlas	Brain Lower Grade Glioma	MTCH2	0.11	0.11	lasso	2	0.10	6.4e-12	11.47	11.5	1.4e-30	0.87	0.09	0.91	FALSE
102	The Cancer Genome Atlas	Brain Lower Grade Glioma	MYBPC3	0.03	0.01	blup	43	0.02	3.2e-03	10.58	-7.8	5.0e-15	-0.72	0.00	0.92	FALSE
103	The Cancer Genome Atlas	Brain Lower Grade Glioma	PSMC3	0.10	0.05	blup	39	0.08	3.7e-09	10.71	9.1	8.2e-20	0.79	0.01	0.99	FALSE
104	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	C1QTNF4	0.19	0.19	lasso	3	0.19	3.2e-09	11.47	-11.5	1.4e-30	-0.87	0.09	0.91	FALSE
105	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	PSMC3	0.09	0.07	blup	39	0.06	8.7e-04	10.58	11.1	1.7e-28	0.85	0.01	0.98	FALSE
106	The Cancer Genome Atlas	Lung Adenocarcinoma	C1QTNF4	0.03	0.02	blup	15	0.02	1.3e-03	13.03	-13.6	6.8e-42	-0.97	0.00	0.97	TRUE
107	The Cancer Genome Atlas	Lung Adenocarcinoma	MYBPC3	0.04	0.02	enet	10	0.04	2.9e-05	10.56	-8.1	5.0e-16	-0.68	0.00	0.98	FALSE
108	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	MADD	0.16	0.05	blup	64	0.08	2.2e-09	-0.51	6.2	5.6e-10	0.10	0.98	0.00	TRUE
109	The Cancer Genome Atlas	Prostate Adenocarcinoma	AGBL2	0.04	0.03	blup	49	0.03	7.8e-04	-9.73	6.8	1.3e-11	0.41	0.18	0.07	FALSE
110	The Cancer Genome Atlas	Prostate Adenocarcinoma	MADD	0.15	0.04	enet	10	0.06	4.5e-07	-6.20	8.1	5.8e-16	0.30	0.20	0.03	FALSE
111	The Cancer Genome Atlas	Prostate Adenocarcinoma	NUP160	0.03	0.02	enet	7	0.02	6.3e-03	10.22	11.7	1.4e-31	0.83	0.02	0.78	FALSE
112	The Cancer Genome Atlas	Prostate Adenocarcinoma	PSMC3	0.02	0.02	blup	39	0.02	5.7e-03	10.71	8.9	7.4e-19	0.78	0.01	0.77	FALSE
113	The Cancer Genome Atlas	Stomach Adenocarcinoma	C1QTNF4	0.06	0.04	lasso	4	0.03	4.3e-03	11.45	-12.1	1.3e-33	-0.92	0.00	0.92	FALSE
114	The Cancer Genome Atlas	Stomach Adenocarcinoma	ZNF408	0.11	0.04	enet	16	0.05	2.0e-04	-4.71	5.2	1.9e-07	0.21	0.01	0.35	FALSE
115	The Cancer Genome Atlas	Testicular Germ Cell Tumors	MADD	0.21	0.04	blup	64	0.07	1.3e-03	-5.12	7.5	6.2e-14	0.28	0.07	0.05	FALSE
116	The Cancer Genome Atlas	Thyroid Carcinoma	C1QTNF4	0.04	0.01	blup	15	0.03	7.9e-04	13.03	-12.7	5.7e-37	-0.89	0.00	0.95	FALSE
117	The Cancer Genome Atlas	Thyroid Carcinoma	MADD	0.07	0.00	enet	11	0.03	6.7e-04	-4.89	8.2	2.4e-16	0.36	0.05	0.13	FALSE