TWAS hub - SELENBP1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.2350	0.050	3.2e-08	0.087	0.068	0.089	0.076	0.084	1.0e-10	1.1e-08	6.2e-11	1.3e-09	2.1e-10
2	GTEx	Thyroid	0.2260	0.049	2.3e-12	0.191	NA	0.228	NA	0.225	1.5e-14	NA	2.3e-17	NA	3.6e-17
3	YFS	Blood	0.0224	0.009	9.0e-05	0.010	0.011	0.006	0.011	0.006	2.0e-04	8.8e-05	4.2e-03	1.1e-04	2.6e-03
4	TCGA	Colon Adenocarcinoma	0.0720	0.043	9.1e-03	0.039	0.037	0.043	NA	0.043	2.6e-03	3.3e-03	1.5e-03	NA	1.7e-03
5	TCGA	Thyroid Carcinoma	0.0640	0.031	1.2e-05	0.022	0.041	0.047	NA	0.044	3.0e-03	6.4e-05	2.3e-05	NA	3.6e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Other serious medical condition/disability diagnosed by doctor	8.2	10.6	18.1	-3.4	-2.8	-4.3	-3.2	-2.3
Seen doctor (GP) for nerves, anxiety, tension or depression	6.3	9.6	18.6	-2.3	-4.3	-1.8	-2.3	-4.0
Impedance of arm (right)	5.5	25.7	60.4	-4.8	-5.8	-1.2	-3.3	-7.8
Mouth/teeth dental problems: Bleeding gums	5.3	6.8	11.7	-2.3	-3.4	-2.6	-1.2	-3.0
Seen a psychiatrist for nerves, anxiety, tension or depression	4.6	5.9	12.8	-1.1	-3.4	-1.9	-0.9	-3.6
Long-standing illness, disability or infirmity	4.5	6.9	9.9	-3.1	-2.6	-2.1	-2.7	-2.5
Impedance of arm (left)	4.4	20.3	42.9	-4.7	-4.9	-1.0	-3.3	-6.5
Bipolar Disorder (2018)	4.3	6.9	12.5	-2.4	-3.5	-2.8	-2.4	-1.5
Heart attack	4.0	5.2	9.1	-1.8	-2.6	-1.3	-2.3	-3.0
Prospective memory result	3.8	4.7	9.6	-0.2	3.0	2.3	-0.2	3.1
Heart attack/myocardial infarction (self-reported)	3.7	4.8	8.1	-1.9	-2.4	-1.2	-2.3	-2.8
Impedance of whole body	3.7	18.9	39.1	-4.2	-5.1	-1.7	-3.0	-6.2
Respiratory disease	3.5	7.8	10.3	-3.2	-3.2	-2.3	-2.4	-2.7
Medication: Levothyroxine sodium	3.5	6.0	8.8	-2.8	-3.0	-1.5	-2.9	-1.5
Had menopause	3.4	4.2	9.2	-3.0	-1.4	-0.4	-2.5	-1.9
Worrier / anxious feelings	3.4	6.4	13.5	-2.2	-3.7	-2.4	-1.0	-2.6
Bipolar Disorder or Schizophrenia	3.3	8.1	16.4	-2.8	-4.1	-2.4	-2.1	-2.5
Relative age voice broke	3.3	5.0	10.5	-0.6	-3.2	-3.1	-0.7	-2.0
Loneliness, isolation	3.3	4.6	6.9	2.6	2.6	1.0	1.6	2.4
Hypothyroidism (self reported)	3.2	7.4	15.6	-3.0	-4.0	-1.6	-1.8	-2.6
Hypothyroidism/myxoedema (self-reported)	3.2	6.3	10.8	-2.6	-3.3	-2.1	-2.4	-1.9
Taking other prescription medications	3.0	4.6	6.4	-2.2	-2.5	-2.2	-2.0	-1.7
Relative age of first facial hair	2.9	6.0	11.1	-1.5	-3.3	-1.8	-1.5	-3.3
Impedance of leg (right)	2.9	14.0	31.7	-2.2	-4.8	-2.6	-1.8	-5.6
Qualifications: NVQ or HND or HNC or equivalent	2.9	3.5	4.5	2.1	1.9	1.9	1.9	1.4
Medication: Aspirin	2.9	3.9	6.5	-2.2	-2.1	-1.4	-1.4	-2.5
Impedance of leg (left)	2.8	13.5	26.2	-2.8	-4.6	-2.6	-2.4	-5.1
Blood clot in the leg (DVT)	2.7	3.5	6.6	-1.7	-1.3	-2.3	-2.6	-1.1
Guilty feelings	2.7	4.1	8.4	-0.4	-2.9	-2.9	-0.3	-2.0
Ever had hysterectomy (womb removed)	2.6	3.0	7.7	-2.8	-0.0	0.6	-2.6	0.2
Allergy	2.6	6.0	11.0	1.0	3.0	3.3	0.6	2.9
Severe depression (siblings)	2.4	2.7	4.9	-2.2	-0.7	-0.3	-2.1	-1.8
Loud music exposure frequency	2.4	2.6	6.9	-2.6	-0.7	0.4	-2.2	-0.7
Allergy or Eczema	2.3	6.0	13.7	-0.1	-3.1	-2.5	0.0	-3.7
Comparative body size at age 10	2.3	6.3	13.6	-0.9	3.7	2.9	-1.0	2.8
Smoking status: Previous	2.3	3.5	5.3	-2.2	-1.6	-2.3	-1.3	-1.8
Illnesses of father: High blood pressure	2.3	2.8	6.2	0.2	-2.5	-2.2	0.8	-1.5
Past tobacco smoking	2.2	4.1	8.3	1.5	2.1	2.9	0.7	2.2
Age at last live birth	2.2	3.1	5.6	-1.6	-2.4	-1.8	-1.1	-1.7
Ever had stillbirth, spontaneous miscarriage or termination	2.2	2.3	5.0	-0.1	-2.2	-1.9	0.2	-1.7
Ever smoked	2.2	3.9	5.5	-1.9	-2.2	-2.1	-0.8	-2.4
Deep venous thrombosis (DVT) (self-reported)	2.2	2.8	5.6	-1.6	-1.1	-1.9	-2.4	-1.1
Ever used hormone-replacement therapy (HRT)	2.1	2.6	6.0	-1.9	-1.1	-1.0	-2.5	-1.1
Body mass index (BMI)	2.1	9.2	17.7	2.4	4.2	2.3	2.4	3.4
Nervous feelings	2.1	3.9	7.7	-1.1	-2.7	-2.8	-0.8	-1.6
Medication: Cholesterol lowering	2.1	3.3	4.7	-2.2	-1.9	-1.3	-1.6	-2.0
Exposure to tobacco smoke outside home	2.1	2.8	7.1	0.4	2.7	2.4	-0.3	1.0
Emphysema/chronic bronchitis	2.1	2.4	5.5	-1.1	-2.3	-1.5	-1.1	-1.3
Medication for pain relief, constipation, heartburn	2.1	3.5	7.7	2.8	1.1	1.2	2.4	1.3
Medication: Aspirin	2.1	2.8	4.2	-2.0	-1.7	-0.9	-1.5	-2.1
Supplements: Calcium	2.1	2.4	4.6	-2.1	-1.1	0.2	-1.6	-1.9
Bipolar Disorder (2011)	2.0	1.9	5.5	0.0	-2.3	-1.6	0.0	-1.3
Schizophrenia (2014)	2.0	4.4	11.0	-1.6	-3.3	-1.8	-0.7	-2.1
Angina (self-reported)	2.0	2.7	5.4	-1.5	-1.5	0.2	-1.9	-2.3
Medication: Seretide 50 evohaler	2.0	2.3	5.0	-0.8	-1.7	-1.7	0.0	-2.2
Commuting to job workplace: Cycle	2.0	2.4	5.2	-1.2	-2.0	-2.3	-1.0	0.0
Prostate Cancer	1.9	2.6	8.1	2.8	1.0	-0.3	0.9	1.8
Type 2 Diabetes (T2D) (2012)	1.9	2.2	4.3	1.4	1.6	-0.6	1.4	2.1
Length of working week for main job	1.9	2.1	4.1	2.0	1.6	-0.1	1.4	1.4
Osteoporosis (self-reported)	1.9	2.4	6.8	-2.2	0.4	0.2	-2.6	-0.0
LDL Cholesterol	1.8	2.9	8.1	-1.5	-1.8	-2.9	-0.6	-0.8
BMI	1.8	10.6	18.0	2.2	4.2	2.8	3.2	3.5
Angina	1.8	2.3	4.1	-1.4	-1.5	0.1	-1.8	-2.0
Frequency of tenseness / restlessness in last 2 weeks	1.8	2.7	6.4	0.1	-2.5	-1.9	0.9	-1.7
Hip circumference	1.8	7.9	15.7	1.4	3.9	4.0	1.9	1.7
Medication: Paracetamol	1.7	2.8	7.7	-1.8	-1.5	-2.8	-0.8	-0.4
Reason for reducing amount of alcohol drunk: Health precaution	1.7	2.0	7.7	1.0	-0.5	-2.8	0.2	0.9
Hearing aid user	1.7	1.9	3.9	0.7	-2.0	-1.3	1.1	-1.5
Major Depression (MDD)	1.6	2.0	3.7	-1.5	-1.7	-1.9	-0.6	-0.8
Falls in the last year	1.6	2.2	2.9	-1.4	-1.6	-0.7	-1.7	-1.7
Asthma	1.6	3.1	4.5	-1.6	-2.1	-1.9	-0.8	-2.0
Age at first live birth	1.6	2.8	4.6	-1.0	-2.2	-1.7	-1.0	-2.1
Qualifications: College or University degree	1.6	4.9	9.0	-0.2	-2.9	-3.0	-0.8	-2.6
Arm predicted mass (right)	1.6	7.9	15.4	2.7	3.9	2.7	1.5	2.7
Gout (self-reported)	1.5	2.1	4.2	1.5	-0.5	-1.8	2.1	-0.7
Arm fat-free mass (right)	1.5	7.6	15.1	2.6	3.9	2.5	1.4	2.7
Medication: Ibuprofen	1.5	1.9	4.0	-1.5	1.0	1.0	-2.0	1.1
Arm fat-free mass (left)	1.5	7.7	14.3	3.0	3.8	2.6	1.8	2.4
Arm predicted mass (left)	1.5	7.6	14.8	2.8	3.9	2.7	1.6	2.4
Coronary Artery Disease (CAD)	1.4	1.6	3.5	0.4	1.8	1.9	0.7	0.9
Medication: Omeprazole	1.4	1.6	3.2	0.1	-1.5	-1.6	0.2	-1.8
Leg pain on walking	1.4	1.7	3.6	-0.2	1.9	1.1	-1.1	1.6
Illness, injury, bereavement, stress in last 2 years	1.4	1.7	4.7	0.8	1.7	0.3	0.2	2.2
Alzheimer’s Disease (in father)	1.3	1.5	4.6	-0.7	-1.3	-0.1	-0.7	-2.1
Blood Platelet Count	1.3	15.3	46.4	2.8	3.7	-2.5	1.4	6.8
Waist Hip Ratio (WHR)	1.3	5.9	18.4	2.1	-2.3	-4.3	0.7	-0.7
Hayfever, allergic rhinitis or eczema	1.3	2.7	5.4	0.9	-1.6	-2.1	0.8	-2.3
Medication: Ramipril	1.3	1.7	4.0	-2.0	-0.8	-0.1	-1.9	-0.8
Hair/balding pattern: Pattern 3	1.3	1.9	4.9	-0.4	2.0	0.3	-0.7	2.2
Medication: Ibuprofen (e.g. Nurofen)	1.3	1.7	2.4	-1.5	1.1	0.8	-1.5	1.3
Headache pain in last month	1.3	2.3	4.5	-1.1	-2.1	-1.9	-0.8	-1.1
Medication for cholesterol, blood pressure or diabetes	1.3	2.2	4.5	0.9	1.8	2.1	0.6	1.4
High blood pressure (siblings)	1.3	1.8	5.8	-0.2	-1.8	-2.4	0.0	-0.4
Handedness (chirality/laterality): Left-handed	1.3	1.5	5.4	-0.4	-2.3	-0.7	0.4	-1.2
Ever depressed for a whole week	1.3	1.6	4.5	-0.6	-1.4	-1.1	-0.5	-2.1
Basal cell carcinoma (self-reported)	1.3	1.5	4.8	-0.4	-1.4	-0.2	-0.7	-2.2
Alcohol drinker status: Previous	1.3	1.5	5.7	0.2	-1.2	-2.4	0.3	-0.6
Schizophrenia (2018)	1.2	2.5	5.6	-1.4	-2.4	-0.8	-0.7	-2.0
High blood pressure (mother)	1.2	1.7	4.1	1.3	-1.2	-2.0	0.8	-0.9
Financial difficulties in last 2 years	1.2	1.6	3.4	0.7	-1.5	-1.9	0.5	-1.3
Birth weight	1.2	2.7	6.3	2.0	-0.6	-2.5	1.6	0.4
Had major operations	1.2	1.3	3.1	-1.8	-0.6	0.1	-1.4	-1.1
Supplements: Vitamin C	1.2	1.5	3.9	-2.0	-0.2	1.2	-0.9	-1.1
Eye problems/disorders: Cataract	1.2	1.3	4.5	-0.2	-0.1	2.1	-0.4	-1.4
Mouth/teeth dental problems: Mouth ulcers	1.2	1.9	4.3	1.2	-1.0	-2.1	1.6	-0.1
Asthma (self-reported)	1.2	2.3	3.6	-1.3	-1.9	-1.9	-0.5	-1.6
Osteoarthritis (self-reported)	1.2	1.5	2.7	1.5	1.2	0.0	1.2	1.6
Number of self-reported non-cancer illnesses	1.2	2.0	3.6	-1.4	-1.7	-1.9	-1.2	-0.4
Wears glasses or contact lenses	1.2	1.4	3.2	0.7	-1.8	-0.7	0.8	-1.5
Alcohol drinker status: Never	1.2	1.5	3.7	-1.3	1.0	1.9	-0.9	0.5
Medication: Omeprazole (e.g. Zanprol)	1.2	1.5	5.0	-0.7	-1.3	-0.3	-0.5	-2.2
Depressed Affect (Nagel 2018)	1.1	2.3	5.2	0.7	2.3	1.3	0.4	2.0
Worry (Nagel 2018)	1.1	2.4	4.2	-1.4	-2.0	-2.1	-0.1	-1.4
Neuroticism (2016)	1.1	1.6	3.9	-2.0	-0.7	0.0	-1.1	-1.6
Blood Eosinophil Count	1.1	8.1	20.4	2.0	-0.0	-4.5	3.5	2.1
Supplements: Zinc	1.1	1.2	2.7	-0.6	0.4	1.6	0.2	-1.6
Average weekly fortified wine intake	1.1	1.2	3.5	0.4	1.9	1.5	-0.0	0.4
Chronic bronchitis/emphysema (father)	1.1	1.3	2.9	0.9	1.7	1.2	-0.5	1.0
Waist circumference	1.1	3.9	6.2	2.2	2.5	0.8	2.1	1.8
Hair/balding pattern: Pattern 4	1.1	2.6	5.6	2.4	-1.6	-1.2	1.4	-1.2
Whole body fat-free mass	1.1	6.0	12.0	2.3	3.5	2.7	1.2	2.1
Mineral and other dietary supplements	1.1	1.5	4.8	1.0	1.3	-0.1	-0.0	2.2
Whole body water mass	1.1	6.1	12.1	2.4	3.5	2.6	1.3	2.1
Vitamin and mineral supplements	1.0	1.4	3.3	1.8	0.3	-0.9	1.1	1.2
Qualifications: CSEs or equivalent	1.0	1.3	2.6	0.9	0.8	1.6	1.4	-0.8
Father’s age at death	1.0	1.4	2.1	-1.2	-1.4	-1.0	-1.4	-0.7
Pulse rate	1.0	1.8	4.0	-0.3	-2.0	-1.1	-0.1	-1.9
Exposure to tobacco smoke at home	1.0	1.2	2.9	1.5	0.4	0.2	1.7	-0.8
Tense / ‘highly strung’	1.0	1.7	4.2	0.2	-1.5	-2.0	0.1	-1.4
Birth weight of first child	1.0	1.8	4.9	1.3	-0.8	-2.2	1.2	-0.4
Illnesses of father: Heart disease	1.0	1.4	5.4	-0.3	-1.2	0.2	-0.3	-2.3
Leg fat-free mass (right)	1.0	5.4	11.8	1.4	3.4	2.9	0.8	2.0
Average weekly red wine intake	1.0	1.5	2.9	-1.2	-1.3	-0.4	-1.7	-1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	3.4	-1.8	0.1	-0.1	-1.5	0.2
Leg predicted mass (right)	1.0	5.4	11.6	1.4	3.4	3.0	0.8	2.0
Pain type(s) experienced in last month: Hip pain	1.0	1.3	3.7	-1.0	1.1	1.9	-0.7	0.2
Basal metabolic rate	1.0	5.8	11.7	2.2	3.4	2.6	1.3	1.9
Average weekly beer plus cider intake	1.0	1.5	3.2	0.7	1.8	1.7	0.6	0.8
Fractured/broken bones in last 5 years	1.0	1.2	4.0	-2.0	-0.1	0.7	-1.3	-0.3
Alzheimer’s Disease (in mother)	0.9	1.0	3.0	-1.7	0.0	0.9	-1.1	0.3
Average weekly spirits intake	0.9	1.1	2.1	0.5	1.0	1.1	0.9	1.4
Medication: Co-codamol	0.9	1.1	2.4	1.2	0.3	-0.7	1.6	1.0
Leg fat-free mass (left)	0.9	5.0	10.1	1.7	3.2	2.9	1.2	1.5
Townsend deprivation index at recruitment	0.9	1.3	3.8	0.1	-1.1	-1.2	0.2	-1.9
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	3.7	-0.9	-0.4	-1.9	-0.3	-0.2
Leg predicted mass (left)	0.9	4.9	10.2	1.6	3.2	3.0	1.0	1.5
Alcohol usually taken with meals	0.9	1.4	4.7	-1.0	0.3	0.1	-2.2	1.2
Forced vital capacity (FVC)	0.9	3.3	7.7	0.9	-2.3	-1.6	0.5	-2.8
Illnesses of siblings	0.9	1.2	2.0	1.1	1.4	1.3	1.0	0.6
Weight	0.9	4.2	8.7	1.8	2.9	2.5	1.5	1.0
Trunk fat-free mass	0.9	5.0	8.8	2.6	3.0	1.9	1.2	1.9
Trunk predicted mass	0.9	5.0	8.9	2.7	3.0	1.9	1.2	1.9
Peak expiratory flow (PEF)	0.9	2.0	4.4	-0.7	-2.1	-1.9	-0.4	-1.1
Medication: Ventolin 100micrograms inhaler	0.9	1.2	2.4	0.7	-1.3	-0.6	0.9	-1.6
Eye problems/disorders: None of the above	0.9	1.0	3.2	0.5	0.1	-1.2	0.4	1.8
Medication: Allopurinol	0.9	1.2	2.2	1.3	-0.3	-1.5	1.2	-0.7
Pulse rate, automated reading	0.9	3.0	5.7	-0.6	-2.1	-2.4	0.1	-2.1
Comparative height size at age 10	0.9	5.1	15.1	-0.3	1.0	3.9	-1.0	-2.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.9	4.4	-2.1	-1.2	0.2	-1.1	-1.5
Medication: Bendroflumethiazide	0.9	1.4	3.4	1.1	-0.6	-1.8	0.9	1.1
Number of operations (self-reported)	0.9	1.3	4.6	-2.1	-0.1	-0.7	-1.1	0.6
Schizophrenia vs Biploar Disorder	0.8	1.1	3.7	-0.9	-0.5	1.0	0.0	-1.9
Height	0.8	14.7	44.0	-1.3	-3.1	1.3	-4.1	-6.6
Cardiovascular Disease	0.8	2.8	6.5	-0.6	-2.5	-2.2	-0.4	-1.4
Hand grip strength (left)	0.8	2.2	6.2	2.5	0.1	0.9	1.8	-0.8
Number of treatments/medications taken	0.8	1.5	2.8	-1.4	-0.7	-1.4	-1.7	-0.3
Hand grip strength (right)	0.8	2.1	5.2	2.3	0.7	1.5	1.6	-0.3
Age when periods started (menarche)	0.8	1.9	6.1	-0.8	-2.5	-0.9	-0.6	-1.3
Mouth/teeth dental problems	0.8	1.3	1.9	1.1	0.8	1.2	1.4	1.2
Medication: Simvastatin	0.8	1.2	2.4	-1.5	-1.2	-1.2	-0.2	-0.8
Forced expiratory volume in 1-second (FEV1)	0.8	2.7	6.1	0.2	-2.3	-1.5	0.1	-2.5
Health satisfaction	0.8	1.0	3.4	-1.9	-0.4	-0.9	-0.8	0.2
Hypertension (Self-reported)	0.8	2.3	4.4	-0.1	-2.1	-2.0	-1.0	-1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	1.9	0.8	-0.7	0.5	1.2	-1.4
Qualifications: nursing, teaching	0.8	1.3	2.7	-0.8	-1.6	-1.2	-0.5	-1.2
Medication: Gliclazide	0.8	0.9	1.4	-0.7	1.0	1.2	-0.6	1.1
Arm fat mass (left)	0.8	3.2	8.3	0.8	2.9	2.2	0.9	1.1
Average weekly champagne plus white wine intake	0.8	1.1	2.9	0.6	0.1	-1.7	0.4	1.5
Medication: Paracetamol	0.8	1.2	4.8	-0.8	-0.7	-2.2	-0.0	0.2
Unable to work because of sickness or disability	0.8	1.0	2.6	-0.8	-0.7	-0.6	-0.9	-1.6
Alzheimer’s Disease (including proxy)	0.7	1.0	2.8	-1.7	-0.8	0.5	-0.8	-0.8
Mean Putamen Volume	0.7	0.8	1.8	1.2	-0.3	0.2	1.4	-0.9
Rheumatoid Arthritis	0.7	0.9	1.6	-1.0	0.7	1.0	-1.3	0.8
Number of live births	0.7	1.0	3.1	-1.8	-0.1	0.3	-1.3	0.6
Noisy workplace	0.7	0.9	1.5	0.1	0.8	-0.9	1.1	1.2
Mouth/teeth dental problems: Dentures	0.7	1.1	3.0	0.6	1.2	1.7	-0.5	0.7
Arm fat mass (right)	0.7	2.8	6.8	0.9	2.6	2.1	1.1	0.8
Standing height	0.7	7.2	23.6	-1.5	-2.3	0.7	-2.1	-4.9
Ever highly irritable/argumentative for 2 days	0.7	0.9	2.0	-1.2	0.9	-0.1	-1.4	0.1
Leg fat mass (right)	0.7	2.6	6.2	1.2	2.5	1.6	1.3	0.9
Suffer from ‘nerves’	0.7	1.1	1.9	-1.0	-1.1	-1.0	-0.5	-1.4
Family relationship satisfaction	0.7	0.8	3.9	0.1	-0.3	-2.0	-0.2	-0.0
Commuting to job workplace: Car/motor vehicle	0.7	0.8	2.4	-0.4	0.2	1.5	-0.4	-1.1
Mood swings	0.7	1.3	3.6	-0.1	1.7	-0.0	0.1	1.9
Commuting to job workplace: Public transport	0.7	0.8	2.7	0.4	-1.2	-1.6	-0.1	-0.1
Eye problems/disorders: Glaucoma	0.7	0.8	2.0	-0.6	-0.5	-1.4	0.1	-1.2
Supplements: Fish oil (including cod liver oil)	0.7	0.9	2.2	0.3	-0.5	0.5	1.2	-1.5
High cholesterol (Self-reported)	0.7	1.2	2.2	-1.5	-1.2	-0.2	-1.2	-0.9
Risk taking	0.7	1.0	1.3	1.0	1.0	-1.2	0.6	1.0
Vascular/heart problems diagnosed by doctor	0.7	1.9	3.0	0.6	1.6	1.2	1.5	1.7
Leg fat mass (left)	0.7	2.6	7.0	1.0	2.7	1.7	1.0	1.2
Breast Cancer	0.6	1.6	4.5	0.9	-0.2	-0.6	2.1	1.4
Lupus	0.6	0.9	3.1	-0.9	-1.8	-0.1	-0.3	-0.8
Hearing difficulty/problems: Yes	0.6	1.0	2.4	-0.7	-0.8	-1.5	-1.2	0.1
Diabetes (mother)	0.6	0.8	1.5	0.9	-0.5	-1.0	1.2	-0.7
Serious illness, injury or assault to yourself	0.6	0.7	2.4	-1.5	-0.5	-0.0	-0.7	-0.6
Multivitamins +/- minerals	0.6	0.8	2.4	-1.5	-0.1	0.7	-0.9	-0.3
Stomach or abdominal pain in last month	0.6	0.8	1.9	-0.0	1.4	0.6	0.7	1.1
Hearing difficulty/problems with background noise	0.6	1.0	3.5	-0.0	-1.2	-1.9	-0.2	-0.3
Had other major operations	0.6	0.8	1.6	-1.1	0.0	-1.3	-0.9	0.4
Hayfever/allergic rhinitis (self-reported)	0.6	0.7	2.1	1.3	0.1	-0.0	1.4	0.1
Illnesses of mother	0.6	0.7	1.1	-0.8	1.1	0.8	-0.5	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.9	3.5	-1.0	-1.9	-1.2	-0.3	-1.9
Forced vital capacity (FVC), Best measure	0.6	2.2	4.4	-0.4	-2.1	-1.5	0.2	-2.1
Medication: Blood pressure	0.6	1.0	2.0	0.0	-1.4	-1.3	-0.1	-1.2
Illnesses of father: None of the above (group 1)	0.6	0.8	2.3	-0.5	1.1	0.3	0.1	1.5
Crohns Disease (2017)	0.5	1.2	1.8	1.0	1.1	1.3	1.2	-0.4
HDL Cholesterol	0.5	0.8	2.4	-0.8	0.9	-0.0	-0.5	1.5
Primary Biliary Cirrhosis	0.5	0.7	2.5	0.1	0.8	0.3	0.4	1.6
Trunk fat percentage	0.5	1.9	4.2	-1.2	0.6	2.0	-0.2	-1.8
Current tobacco smoking	0.5	0.8	2.8	0.6	0.5	1.7	-0.2	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	1.3	1.0	0.4	0.5	1.2	-0.5
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.8	-0.5	0.3	1.3	-0.8	-0.4
High blood pressure	0.5	1.3	2.2	0.3	-1.5	-1.4	-0.7	-1.3
Qualifications: None of the above	0.5	1.0	1.7	1.0	1.1	0.7	0.7	1.3
Pain all over the body in last month	0.5	0.5	0.9	-0.8	-0.7	-0.7	-1.0	-0.3
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.6	1.3	0.1	0.2	1.1	-0.1
Glaucoma (self-reported)	0.5	0.6	1.4	-1.2	0.2	-0.1	-0.5	-1.2
Leg fat percentage (right)	0.5	1.8	3.1	1.4	1.8	0.7	1.7	0.5
Heart disease (mother)	0.5	0.7	1.4	0.1	-1.2	-1.1	0.4	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.4	0.4	1.2	0.9	0.1	0.8
Commuting to job workplace: Walk	0.5	0.5	1.8	0.5	0.5	0.5	1.3	0.0
Medication: Lisinopril	0.5	0.7	2.0	1.4	-0.5	-0.5	0.8	0.3
Diastolic blood pressure, automated reading	0.5	1.4	2.7	1.0	-1.3	-1.1	1.6	-0.9
Cholesterol lowering medication	0.5	0.8	1.6	0.3	-1.2	-0.1	0.7	-1.3
Intelligence (Savage-Jansen 2018)	0.4	1.2	2.9	-0.2	-0.9	-0.7	-1.3	-1.7
Verbal and Numeric Reasoning (VNR)	0.4	0.9	2.2	-0.9	0.9	0.7	-1.5	-0.3
Age at First Birth	0.4	0.6	1.1	-0.9	-0.1	1.0	-1.0	0.2
Body Mass Index (BMI) (2010)	0.4	0.6	2.2	0.7	0.5	0.3	1.5	0.3
Fasting Glucose	0.4	0.5	1.4	0.3	-1.2	-0.1	0.5	-0.9
Ulcerative Colitis	0.4	0.6	1.5	-0.4	-1.2	-0.9	0.1	-0.7
Smoking Status	0.4	1.0	1.8	-1.1	-0.8	-0.5	-1.0	-1.4
Lung FVC	0.4	2.2	5.8	-0.8	-2.0	-2.4	0.1	-0.7
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	0.8	-0.3	0.8	0.6	0.9	0.2
Medication for hormone replacement therapy	0.4	0.4	1.1	-0.3	-0.7	-1.1	-0.7	-0.1
Pack years adult smoking proportion	0.4	0.6	1.5	1.2	0.3	0.4	1.1	-0.2
Sitting height	0.4	2.6	10.0	0.3	-1.5	0.1	-0.9	-3.2
Trunk fat mass	0.4	1.5	4.7	-0.4	1.3	2.2	0.1	-1.1
Hair/balding pattern: Pattern 2	0.4	0.5	1.1	-0.9	0.2	1.1	0.6	-0.5
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.5	0.0	-0.9	-1.2	0.0	-0.4
Neuroticism score	0.4	0.9	2.4	0.0	-1.0	-1.6	0.1	-0.9
Pulse wave reflection index	0.4	0.5	1.2	-0.2	-0.9	-1.1	0.1	-0.7
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.2	-1.1	0.6	0.7	-0.6	-0.4
Worry too long after embarrassment	0.4	0.7	2.9	-0.3	-0.6	-1.7	-0.0	-0.2
Neck or shoulder pain in last month	0.4	0.5	1.4	-0.4	0.0	-0.8	-0.6	1.2
Migraine (self-reported)	0.4	0.5	0.7	-0.9	0.2	0.7	-0.8	0.8
Whole body fat mass	0.4	1.8	5.0	0.2	1.9	2.2	0.5	-0.2
Number of full sisters	0.4	0.5	1.0	-1.0	-0.8	-0.8	-0.3	-0.3
Overall health rating	0.4	0.8	2.2	-1.5	0.4	0.0	-1.2	0.5
Chest pain or discomfort	0.4	0.6	1.4	-1.2	-0.3	-0.7	-0.7	-0.6
Knee pain experienced in last month	0.4	0.6	1.7	-0.8	-0.4	-0.7	-1.3	-0.3
Illnesses of siblings: Diabetes	0.4	0.4	0.9	1.0	0.2	0.3	0.9	-0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	2.3	-0.1	-1.2	-0.4	-0.6	-1.5
Ever had bowel cancer screening	0.4	0.4	1.3	-1.1	0.1	0.4	-0.7	0.3
Miserableness	0.4	0.7	1.4	0.5	1.1	0.8	1.2	0.3
Financial situation satisfaction	0.4	0.5	1.0	-0.1	0.8	-0.9	0.2	1.0
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.3	-1.1	-0.9	0.2	-0.3	-0.6
Medication: Atorvastatin	0.4	0.5	1.8	0.5	-0.8	-0.0	-0.1	-1.3
Leg fat percentage (left)	0.4	1.6	3.7	1.1	1.9	0.7	1.3	0.9
Irritability	0.4	0.6	1.8	-0.8	0.8	-0.2	-1.3	-0.0
Age started oral contraceptive pill	0.4	0.5	0.9	1.0	-0.8	-0.0	0.9	0.2
Depression (Nagel 2018)	0.3	0.4	1.0	0.2	0.9	1.0	0.6	0.0
Irritable Bowel Disease (IBD)	0.3	0.8	1.5	0.7	0.0	1.2	1.0	-0.9
Reaction Time	0.3	0.6	0.7	-0.8	0.8	-0.7	-0.6	0.8
Blood Red Count	0.3	3.3	7.3	-2.2	-2.7	-0.7	-1.6	-1.1
Blood White Count	0.3	2.0	5.9	1.0	0.5	-1.3	1.2	2.4
Fed-up feelings	0.3	0.6	1.9	0.7	-0.6	-1.4	0.4	-0.4
Number of incorrect matches in round	0.3	0.4	1.1	0.4	0.4	-0.2	1.1	0.8
Alcohol intake versus 10 years previously	0.3	0.4	0.8	0.9	0.4	0.5	0.4	-0.7
Qualifications: A levels/AS levels or equivalent	0.3	0.6	1.9	0.4	-0.3	-0.5	-0.9	-1.4
Medication: Lansoprazole	0.3	0.3	0.5	0.5	-0.6	-0.1	0.7	-0.7
Pulse wave Arterial Stiffness index	0.3	0.3	0.6	0.5	-0.7	0.0	0.7	-0.5
Body fat percentage	0.3	1.1	3.0	-0.6	0.9	1.7	0.2	-1.2
Number of children fathered	0.3	0.3	1.1	-1.1	0.1	-0.4	-0.6	-0.0
Pulse wave peak to peak time	0.3	0.4	1.0	-0.8	0.6	-0.2	-1.0	0.2
Alcohol intake frequency.	0.3	0.6	2.1	-1.4	-0.6	-0.1	-0.2	-0.7
Arm fat percentage (left)	0.3	1.3	3.4	-0.1	1.9	1.6	0.6	0.3
Friendships satisfaction	0.3	0.4	1.4	0.5	-0.2	-1.2	-0.1	-0.1
Medication for cholesterol	0.3	0.5	1.2	-0.6	1.1	0.5	0.2	0.7
Smoking status: Current	0.3	0.5	1.7	0.6	0.2	1.3	-0.2	-0.6
Ever taken oral contraceptive pill	0.3	0.4	1.2	-0.5	-1.1	-0.6	0.2	0.3
Mother’s age at death	0.3	0.4	1.6	-0.7	-0.3	1.2	-0.2	-0.0
Pain experienced in last month	0.3	0.6	2.0	-0.2	0.2	0.9	-0.1	-1.4
Pack years of smoking	0.3	0.4	1.0	1.0	-0.0	0.2	1.0	-0.4
Crohns Disease (2012)	0.2	0.3	0.9	0.4	0.2	0.4	0.4	-1.0
HbA1C	0.2	0.3	0.9	0.1	0.7	-0.2	0.0	0.9
Heel T-Score	0.2	1.5	4.8	-1.6	0.1	-0.4	-2.2	-0.3
Chronotype (morning person)	0.2	0.4	1.9	-1.4	0.2	-0.1	-0.4	0.3
Hair Pigment	0.2	6.1	11.4	3.4	-0.5	-3.0	3.1	-0.0
Tanning	0.2	2.6	7.3	1.1	1.2	-1.6	0.6	2.7
Sensitivity / hurt feelings	0.2	0.3	0.8	0.3	0.9	0.6	-0.6	0.1
Systolic blood pressure, automated reading	0.2	0.6	1.1	1.0	0.5	1.0	0.5	0.6
Medication: Metformin	0.2	0.4	0.7	-0.5	-0.5	-0.8	-0.4	-0.6
Diabetes (father)	0.2	0.3	0.6	-0.8	-0.4	-0.4	-0.7	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	1.8	-0.9	-0.2	0.0	-1.3	-0.0
Supplements: Glucosamine	0.2	0.2	0.8	-0.1	0.1	0.9	0.4	-0.5
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.7	0.3	-0.4	0.3	0.9	0.2
Diabetes (self-reported)	0.2	0.2	0.5	-0.3	-0.2	-0.7	-0.2	-0.7
Fluid intelligence score	0.2	0.4	1.1	-0.2	-0.8	-0.3	-0.4	-1.1
Arm fat percentage (right)	0.2	0.9	2.0	-0.1	1.4	1.4	0.6	-0.3
Depression (self-reported)	0.2	0.2	0.7	0.1	-0.0	0.6	-0.8	-0.4
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	1.2	-0.1	0.6	0.3	-0.4	-1.1
Number of full brothers	0.2	0.3	1.1	-0.6	0.0	0.2	-0.1	-1.0
Wheeze or whistling in the chest in last year	0.2	0.3	1.3	-0.1	0.3	-1.1	-0.0	0.5
Shortness of breath walking on level ground	0.2	0.3	0.5	-0.6	0.3	0.7	-0.4	0.5
Mouth/teeth dental problems: Loose teeth	0.2	0.3	1.3	-0.0	1.1	-0.1	-0.2	0.2
Mean time to correctly identify matches	0.2	0.4	0.9	-0.9	0.3	-0.5	-0.9	-0.1
Back pain experienced in last month	0.2	0.3	0.9	0.5	-0.0	-1.0	0.1	0.7
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.4	0.3	-0.3	-0.6	0.1	0.6
Myopia	0.2	0.3	0.5	0.7	-0.5	0.1	0.7	0.4
Ulcerative Colitis (UC)	0.1	0.3	0.6	0.6	-0.3	0.5	0.8	-0.1
Ovarian Cancer	0.1	0.1	0.3	-0.0	0.6	-0.4	-0.2	0.3
Triglycerides	0.1	0.1	0.2	-0.3	0.1	-0.3	-0.2	0.5
Systolic Blood Pressure	0.1	0.6	2.3	1.5	0.1	0.1	0.4	0.7
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.6	0.5	0.0	-0.6	0.8	0.0
Lung FEV1/FVC ratio	0.1	0.5	0.9	-0.9	-0.7	0.2	-0.6	-0.9
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.8	0.0	-0.1	0.4	0.2	-0.9
Maternal smoking around birth	0.1	0.2	0.8	0.1	0.9	0.1	0.1	0.4
Time employed in main current job	0.1	0.1	0.2	-0.0	-0.5	-0.4	0.1	-0.2
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.2	-0.5	0.1	-0.1	-0.3	0.2
Happiness	0.1	0.1	0.4	-0.3	-0.3	-0.0	-0.7	0.2
Breastfed as a baby	0.1	0.2	0.6	0.1	-0.1	0.8	-0.2	0.4
Medication: Amlodipine	0.1	0.1	0.4	0.6	0.1	0.4	0.2	-0.1
Diabetes diagnosed by doctor	0.1	0.1	0.2	-0.2	-0.1	-0.5	0.2	-0.4
Breast cancer (self-reported)	0.1	0.1	0.2	-0.4	-0.1	-0.0	0.4	0.3
Medication: Blood pressure	0.1	0.2	0.7	0.9	-0.4	-0.1	-0.1	0.0
Heart disease (siblings)	0.1	0.2	0.3	-0.4	-0.4	-0.4	-0.3	-0.5
Neuroticism (Nagel 2018)	0.0	0.1	0.3	-0.4	0.6	-0.0	0.1	0.2
Neuroticism	0.0	0.1	0.1	-0.3	0.1	-0.2	0.3	0.2
Medication: Atenolol	0.0	0.1	0.2	0.1	-0.0	0.1	-0.3	0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.1	0.2	-0.3	-0.1	-0.1	-0.4	-0.0
Lung cancer (father)	0.0	0.0	0.1	0.3	-0.1	-0.1	0.2	0.1

Hub : Genes

SELENBP1

Models

Trait associations