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chr13:46,431,021-52,223,199

Best TWAS P=2.98e-99 · Best GWAS P=9.2e-189 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	DLEU7	0.05	0.00	blup	581	0.02	1.6e-03	3.162	10.3	5.5e-25	-0.35	0.10	0.03	TRUE
2	CommonMind	Brain Pre-frontal Cortex	EBPL	0.34	0.16	bslmm	399	0.33	2.5e-41	2.538	-12.4	4.0e-35	0.08	1.00	0.00	FALSE
3	CommonMind	Brain Pre-frontal Cortex	LRCH1	0.07	0.00	blup	661	0.01	5.6e-03	0.567	-6.2	4.0e-10	-0.04	0.13	0.14	FALSE
4	CommonMind	Brain Pre-frontal Cortex	PHF11	0.05	0.02	bslmm	404	0.02	6.7e-04	0.017	-6.7	1.7e-11	-0.16	0.49	0.11	FALSE
5	CommonMind	Brain Pre-frontal Cortex	RCBTB1	0.14	0.13	lasso	2	0.11	1.3e-13	-6.041	5.9	3.5e-09	-0.03	1.00	0.00	FALSE
6	CommonMind	Brain Pre-frontal Cortex	SPRYD7	0.07	0.06	lasso	3	0.07	1.5e-08	-0.909	-6.2	4.3e-10	0.30	1.00	0.00	FALSE
7	CommonMind	Brain Pre-frontal Cortex	TRIM13	0.15	0.04	lasso	5	0.12	1.1e-14	20.768	-16.6	9.2e-62	0.35	1.00	0.00	FALSE
8	GTEx	Adipose Subcutaneous	EBPL	0.45	0.29	enet	37	0.39	1.5e-33	2.538	-8.6	5.5e-18	0.10	1.00	0.00	FALSE
9	GTEx	Adipose Subcutaneous	LRCH1	0.07	0.05	lasso	3	0.05	3.9e-05	-5.669	-6.8	1.0e-11	-0.01	0.65	0.32	TRUE
10	GTEx	Adipose Visceral Omentum	EBPL	0.27	0.03	enet	17	0.20	1.4e-10	16.099	-11.9	1.2e-32	0.16	0.77	0.14	FALSE
11	GTEx	Adipose Visceral Omentum	RB1	0.08	0.01	lasso	6	0.02	3.3e-02	7.988	-8.1	7.6e-16	-0.07	0.04	0.71	FALSE
12	GTEx	Artery Aorta	EBPL	0.43	0.20	enet	78	0.28	8.1e-16	13.622	-12.5	5.9e-36	0.17	0.99	0.01	FALSE
13	GTEx	Artery Coronary	EBPL	0.48	0.03	enet	99	0.12	9.7e-05	16.099	-11.1	9.4e-29	0.09	0.17	0.44	FALSE
14	GTEx	Artery Tibial	EBPL	0.55	0.32	enet	28	0.46	4.5e-40	2.538	-9.4	5.6e-21	0.08	1.00	0.00	FALSE
15	GTEx	Brain Caudate basal ganglia	EBPL	0.41	0.06	lasso	7	0.12	2.1e-04	13.394	-10.6	2.2e-26	0.02	0.12	0.08	FALSE
16	GTEx	Brain Cerebellar Hemisphere	EBPL	0.54	0.32	enet	17	0.34	1.2e-09	2.538	-12.5	7.6e-36	0.12	0.62	0.07	FALSE
17	GTEx	Brain Cerebellum	EBPL	0.50	0.30	enet	23	0.36	1.8e-11	16.099	-14.5	5.9e-48	0.07	0.86	0.02	FALSE
18	GTEx	Brain Cortex	EBPL	0.36	0.08	enet	24	0.14	1.5e-04	16.099	-12.3	1.3e-34	0.15	0.19	0.10	FALSE
19	GTEx	Brain Frontal Cortex BA9	EBPL	0.50	0.20	enet	18	0.34	7.0e-10	2.538	-11.2	3.5e-29	0.05	0.33	0.31	FALSE
20	GTEx	Brain Nucleus accumbens basal ganglia	EBPL	0.25	0.11	enet	21	0.11	7.9e-04	13.661	-12.1	1.1e-33	0.14	0.11	0.22	FALSE
21	GTEx	Brain Putamen basal ganglia	EBPL	0.31	-0.01	enet	18	0.05	2.9e-02	13.661	-14.4	1.0e-46	0.11	0.04	0.43	TRUE
22	GTEx	Breast Mammary Tissue	EBPL	0.21	0.15	enet	20	0.17	2.8e-09	-5.493	-10.1	5.4e-24	0.17	0.91	0.04	FALSE
23	GTEx	Breast Mammary Tissue (Male)	EBPL	0.20	0.05	enet	6	0.03	7.9e-02	2.425	-10.7	1.5e-26	0.17	0.04	0.18	FALSE
24	GTEx	Breast Mammary Tissue (Male)	RNASEH2B	0.06	-0.01	enet	25	-0.01	5.4e-01	-0.233	7.8	5.4e-15	-0.04	0.05	0.09	TRUE
25	GTEx	Cells EBV-transformed lymphocytes	EBPL	0.41	0.36	lasso	10	0.37	3.8e-13	-5.493	-8.4	4.8e-17	0.07	0.99	0.00	FALSE
26	GTEx	Cells EBV-transformed lymphocytes	LRCH1	0.39	-0.01	lasso	11	-0.01	6.6e-01	0.671	5.7	1.6e-08	-0.01	0.06	0.09	FALSE
27	GTEx	Cells Transformed fibroblasts	EBPL	0.29	0.17	lasso	3	0.22	1.8e-16	-5.493	-11.4	3.2e-30	0.06	1.00	0.00	FALSE
28	GTEx	Cells Transformed fibroblasts	LRCH1	0.11	0.00	enet	14	0.02	1.9e-02	-7.081	-6.1	8.9e-10	0.04	0.20	0.08	FALSE
29	GTEx	Cells Transformed fibroblasts	RCBTB1	0.20	0.12	lasso	8	0.11	1.4e-08	-3.123	5.2	2.0e-07	-0.05	0.99	0.00	FALSE
30	GTEx	Cells Transformed fibroblasts	RB1	0.08	0.01	enet	9	0.00	1.4e-01	8.096	-7.4	1.2e-13	-0.08	0.03	0.64	FALSE
31	GTEx	Colon Sigmoid	SETDB2	0.28	0.00	enet	56	0.07	2.5e-03	-1.059	5.3	1.2e-07	-0.10	0.07	0.05	FALSE
32	GTEx	Colon Transverse	EBPL	0.24	0.19	enet	13	0.11	8.8e-06	-5.493	-10.0	1.0e-23	0.09	0.97	0.01	FALSE
33	GTEx	Esophagus Gastroesophageal Junction	EBPL	0.27	0.24	enet	14	0.26	4.6e-10	13.394	-14.2	1.5e-45	0.02	0.97	0.03	FALSE
34	GTEx	Esophagus Muscularis	CDADC1	0.15	0.00	enet	20	0.00	2.3e-01	2.270	-8.1	8.3e-16	-0.10	0.06	0.04	TRUE
35	GTEx	Esophagus Muscularis	EBPL	0.39	0.16	enet	36	0.29	9.2e-18	13.622	-13.0	1.0e-38	0.04	1.00	0.00	FALSE
36	GTEx	Heart Atrial Appendage	EBPL	0.17	0.04	lasso	5	0.05	2.2e-03	16.099	-12.6	3.7e-36	0.10	0.12	0.57	FALSE
37	GTEx	Muscle Skeletal	CDADC1	0.10	0.04	enet	10	0.02	1.6e-03	2.203	5.8	6.9e-09	-0.03	0.80	0.02	TRUE
38	GTEx	Muscle Skeletal	RCBTB1	0.19	0.11	enet	43	0.14	1.7e-13	-5.578	-5.6	2.5e-08	0.02	1.00	0.00	FALSE
39	GTEx	Nerve Tibial	EBPL	0.33	0.09	enet	25	0.27	4.6e-19	13.394	-11.5	1.1e-30	0.13	1.00	0.00	FALSE
40	GTEx	Nerve Tibial	LRCH1	0.12	0.03	enet	12	0.02	1.0e-02	-6.849	-6.2	6.5e-10	-0.08	0.59	0.03	FALSE
41	GTEx	Nerve Tibial	DLEU2	0.11	0.05	lasso	3	0.02	7.8e-03	20.994	21.1	3.0e-99	-0.17	0.51	0.02	TRUE
42	GTEx	Pancreas	EBPL	0.18	0.10	enet	5	0.09	1.6e-04	16.099	-14.7	1.2e-48	0.10	0.36	0.08	TRUE
43	GTEx	Pancreas	SUCLA2	0.18	0.08	enet	25	0.05	2.8e-03	5.207	-6.5	8.2e-11	0.00	0.04	0.41	FALSE
44	GTEx	Pituitary	EBPL	0.44	0.32	enet	29	0.37	3.1e-10	13.622	-13.1	2.3e-39	-0.03	0.71	0.24	FALSE
45	GTEx	Pituitary	RB1	0.30	0.06	enet	29	0.09	2.3e-03	8.220	-5.5	3.1e-08	-0.04	0.03	0.73	FALSE
46	GTEx	Skin Not Sun Exposed Suprapubic	EBPL	0.34	0.26	enet	12	0.30	4.0e-17	13.622	-12.0	4.6e-33	-0.02	1.00	0.00	FALSE
47	GTEx	Skin Sun Exposed Lower leg	EBPL	0.28	0.21	lasso	5	0.20	2.5e-16	13.556	-14.3	1.1e-46	0.02	1.00	0.00	FALSE
48	GTEx	Small Intestine Terminal Ileum	EBPL	0.39	0.10	lasso	8	0.14	4.3e-04	-5.493	-6.8	9.9e-12	0.06	0.07	0.11	FALSE
49	GTEx	Small Intestine Terminal Ileum	RNASEH2B	0.57	0.01	enet	40	0.11	2.4e-03	-1.868	6.4	1.4e-10	-0.18	0.05	0.18	TRUE
50	GTEx	Small Intestine Terminal Ileum	RCBTB1	0.29	0.12	lasso	4	0.10	3.4e-03	0.913	5.8	5.0e-09	0.07	0.08	0.21	FALSE
51	GTEx	Spleen	EBPL	0.58	0.33	enet	28	0.35	7.1e-10	-5.493	-7.7	1.9e-14	0.01	0.71	0.03	FALSE
52	GTEx	Spleen	RCBTB1	0.37	0.02	lasso	5	0.04	3.5e-02	1.510	-12.3	9.9e-35	0.03	0.04	0.10	FALSE
53	GTEx	Stomach	EBPL	0.25	0.17	enet	10	0.20	7.0e-10	2.538	-8.8	9.7e-19	0.07	0.98	0.00	FALSE
54	GTEx	Testis	EBPL	0.33	0.17	lasso	6	0.24	8.4e-11	13.658	-16.1	4.3e-58	0.05	0.99	0.01	TRUE
55	GTEx	Testis	RCBTB1	0.17	0.03	lasso	2	0.07	5.6e-04	-4.097	-5.3	1.1e-07	-0.06	0.34	0.04	FALSE
56	GTEx	Thyroid	EBPL	0.36	0.14	enet	33	0.30	5.1e-23	13.394	-15.7	2.1e-55	0.12	1.00	0.00	TRUE
57	METSIM	Adipose	EBPL	0.32	0.12	lasso	7	0.27	1.4e-39	13.658	-11.3	1.2e-29	0.04	1.00	0.00	FALSE
58	METSIM	Adipose	LRCH1	0.04	0.03	lasso	4	0.03	1.2e-05	-5.460	-6.8	1.4e-11	-0.01	0.99	0.01	FALSE
59	NTR	Blood	DLEU7	0.07	0.02	enet	22	0.06	1.3e-19	-10.295	-16.8	1.1e-63	0.63	0.52	0.48	TRUE
60	NTR	Blood	EBPL	0.07	0.03	blup	401	0.04	3.8e-13	2.538	-9.1	8.2e-20	0.07	1.00	0.00	FALSE
61	NTR	Blood	ITM2B	0.02	0.02	enet	7	0.02	1.5e-07	8.096	8.1	5.0e-16	0.05	0.04	0.96	TRUE
62	ROSMAP	Brain Pre-frontal Cortex	EBPL	0.43	0.28	lasso	8	0.43	7.3e-60	13.394	-12.5	1.2e-35	0.04	1.00	0.00	FALSE
63	YFS	Blood	DLEU1	0.13	0.12	lasso	10	0.16	7.4e-49	-1.251	-5.3	1.2e-07	-0.22	1.00	0.00	TRUE
64	YFS	Blood	EBPL	0.52	0.36	lasso	8	0.48	4.8e-183	-5.493	-7.3	2.8e-13	0.03	1.00	0.00	FALSE
65	YFS	Blood	KPNA3	0.04	0.02	bslmm	427	0.02	1.4e-08	1.008	7.3	2.3e-13	-0.14	1.00	0.00	FALSE
66	The Cancer Genome Atlas	Breast Invasive Carcinoma	DLEU2	0.05	0.01	enet	15	0.02	2.0e-05	-5.566	7.5	7.5e-14	-0.08	0.06	0.24	FALSE
67	The Cancer Genome Atlas	Breast Invasive Carcinoma	EBPL	0.07	0.03	enet	11	0.06	2.1e-12	13.661	-11.3	9.1e-30	0.05	0.06	0.94	FALSE
68	The Cancer Genome Atlas	Breast Invasive Carcinoma	RNASEH2B	0.22	0.01	blup	78	0.07	2.0e-13	4.271	-5.4	7.5e-08	-0.04	0.02	0.69	TRUE
69	The Cancer Genome Atlas	Colon Adenocarcinoma	EBPL	0.20	0.04	blup	59	0.11	6.8e-07	-5.493	-10.9	7.1e-28	0.14	0.60	0.24	FALSE
70	The Cancer Genome Atlas	Glioblastoma Multiforme	EBPL	0.45	0.24	blup	59	0.24	5.3e-08	-5.493	-6.8	1.1e-11	0.09	0.35	0.26	FALSE
71	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	DLEU7	0.11	0.00	enet	36	0.03	1.8e-04	3.858	-6.8	1.5e-11	0.09	0.01	0.06	TRUE
72	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DLEU2	0.08	0.02	lasso	2	0.01	1.6e-02	-10.735	13.5	1.8e-41	0.01	0.13	0.25	FALSE
73	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	EBPL	0.21	0.14	enet	15	0.19	3.6e-21	-5.493	-11.0	2.4e-28	0.12	1.00	0.00	TRUE
74	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SUCLA2	0.06	0.02	blup	61	0.03	1.1e-04	5.806	-5.4	5.4e-08	-0.05	0.01	0.98	TRUE
75	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	CYSLTR2	0.05	0.04	lasso	5	0.04	3.1e-03	6.420	-6.7	2.2e-11	-0.04	0.05	0.45	FALSE
76	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	DLEU1	0.13	0.04	lasso	3	0.04	2.6e-03	13.255	-11.1	7.6e-29	-0.04	0.24	0.03	FALSE
77	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	EBPL	0.27	0.16	blup	59	0.22	1.0e-12	-5.493	-13.6	6.3e-42	0.12	0.29	0.71	FALSE
78	The Cancer Genome Atlas	Brain Lower Grade Glioma	EBPL	0.22	0.12	enet	7	0.18	2.5e-20	2.538	-11.3	8.4e-30	0.07	0.88	0.12	FALSE
79	The Cancer Genome Atlas	Lung Adenocarcinoma	EBPL	0.07	0.02	blup	59	0.03	8.9e-05	2.538	-10.2	1.6e-24	0.13	0.02	0.81	FALSE
80	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	DLEU2	0.03	0.01	blup	61	0.02	2.4e-03	20.666	20.0	2.6e-89	-0.20	0.01	0.96	FALSE
81	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	EBPL	0.21	0.09	enet	10	0.13	4.9e-06	16.099	-12.1	8.3e-34	0.11	0.00	1.00	TRUE
82	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	EBPL	0.28	0.18	blup	59	0.19	4.3e-08	13.661	-13.7	8.9e-43	0.13	0.01	0.98	FALSE
83	The Cancer Genome Atlas	Prostate Adenocarcinoma	EBPL	0.08	0.01	blup	59	0.04	6.4e-05	13.661	-13.0	2.0e-38	0.12	0.01	0.89	FALSE
84	The Cancer Genome Atlas	Rectum Adenocarcinoma	GUCY1B2	0.43	0.00	blup	104	0.14	3.2e-04	-1.636	5.7	1.5e-08	0.02	0.02	0.10	TRUE
85	The Cancer Genome Atlas	Soft Tissue Sarcoma	EBPL	0.11	0.01	enet	10	0.03	4.9e-03	-6.476	-6.1	1.2e-09	0.10	0.05	0.09	FALSE
86	The Cancer Genome Atlas	Stomach Adenocarcinoma	EBPL	0.10	0.07	enet	7	0.08	2.8e-06	16.099	-13.0	1.7e-38	0.17	0.00	1.00	FALSE
87	The Cancer Genome Atlas	Testicular Germ Cell Tumors	RCBTB1	0.13	0.07	lasso	4	0.08	1.2e-03	-5.619	-6.2	5.8e-10	0.02	0.06	0.69	TRUE
88	The Cancer Genome Atlas	Thyroid Carcinoma	CYSLTR2	0.04	0.03	blup	82	0.05	2.3e-05	6.750	7.1	1.2e-12	0.05	0.02	0.98	FALSE
89	The Cancer Genome Atlas	Thyroid Carcinoma	EBPL	0.28	0.10	enet	17	0.26	7.7e-25	-5.493	-11.3	9.1e-30	0.04	0.24	0.76	FALSE
90	The Cancer Genome Atlas	Thyroid Carcinoma	TRIM13	0.04	0.00	blup	26	0.02	8.5e-03	21.017	-16.3	1.4e-59	0.01	0.00	0.46	FALSE