Hub : Genes

CYSLTR2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 TCGA Kidney Renal Papillary Cell Carcinoma 0.054 0.031 0.00720 0.044 0.037 0.016 NA 0.038 0.00150 3.4e-03 0.04000 NA 0.00310
2 TCGA Thyroid Carcinoma 0.044 0.023 0.00034 0.032 0.047 0.031 NA 0.037 0.00042 2.3e-05 0.00051 NA 0.00015

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.5 0.9 1.3 -0.6 1.1
Bipolar Disorder or Schizophrenia 0.7 1.7 2.3 -1.0 1.5
Depressed Affect (Nagel 2018) 0.5 1.1 1.1 1.1 -1.0
Depression (Nagel 2018) 0.3 0.4 0.5 0.7 -0.7
Intelligence (Savage-Jansen 2018) 0.5 1.4 1.6 -1.3 1.2
Neuroticism (Nagel 2018) 0.0 0.0 0.0 0.1 0.1
Schizophrenia (2018) 0.4 0.8 1.1 -0.8 1.0
Schizophrenia vs Biploar Disorder 1.3 1.7 1.8 1.3 -1.3
Worry (Nagel 2018) 0.1 0.2 0.3 -0.6 0.4
Alzheimer’s Disease (in mother) 0.3 0.3 0.6 0.8 -0.2
Alzheimer’s Disease (in father) 0.6 0.7 1.3 -1.2 0.0
Alzheimer’s Disease (including proxy) 0.0 0.0 0.0 -0.2 0.1
Crohns Disease (2017) 0.4 0.9 1.1 0.8 -1.1
Irritable Bowel Disease (IBD) 0.7 1.6 2.2 1.0 -1.5
Ulcerative Colitis (UC) 1.1 2.1 2.6 1.3 -1.6
Major Depression (MDD) 0.2 0.2 0.4 0.3 -0.6
Reaction Time 0.5 1.0 1.2 -0.9 1.1
Verbal and Numeric Reasoning (VNR) 0.1 0.1 0.2 0.0 -0.5
Breast Cancer 0.8 2.0 2.3 -1.3 1.5
Ovarian Cancer 0.8 1.1 1.8 -1.3 0.7
Prostate Cancer 0.0 0.0 0.1 0.0 0.3
Age at First Birth 0.2 0.3 0.4 -0.6 0.4
Bipolar Disorder (2011) 0.0 0.0 0.0 0.2 0.1
Body Mass Index (BMI) (2010) 1.0 1.4 1.5 -1.2 1.2
Coronary Artery Disease (CAD) 2.0 2.4 3.3 -1.8 1.2
Crohns Disease (2012) 0.5 0.8 1.2 0.6 -1.1
Mean Putamen Volume 0.0 0.0 0.0 0.2 0.1
Fasting Glucose 1.7 2.0 2.6 -1.2 1.6
HbA1C 0.5 0.5 1.0 1.0 0.0
HDL Cholesterol 0.0 0.1 0.1 -0.2 -0.3
LDL Cholesterol 0.1 0.2 0.3 -0.6 0.3
Lupus 1.0 1.5 2.0 -1.0 1.4
Neuroticism (2016) 0.4 0.6 1.1 0.4 -1.0
Primary Biliary Cirrhosis 0.0 0.0 0.0 0.2 0.2
Rheumatoid Arthritis 0.0 0.0 0.0 -0.1 0.0
Schizophrenia (2014) 0.5 1.1 1.2 -1.0 1.1
Triglycerides 0.9 1.5 2.0 1.4 -1.0
Type 2 Diabetes (T2D) (2012) 1.1 1.2 2.0 -0.6 1.4
Ulcerative Colitis 0.1 0.2 0.3 0.2 -0.5
Blood Eosinophil Count 0.7 5.5 6.3 2.1 -2.5
Blood Platelet Count 0.3 4.1 4.2 2.0 -2.0
Blood Red Count 0.6 6.3 7.6 -2.2 2.8
Blood White Count 0.5 3.6 3.9 -1.8 2.0
Heel T-Score 0.4 2.9 4.7 1.1 -2.2
BMI 0.0 0.3 0.3 -0.5 0.6
Height 2.5 47.7 50.6 -6.7 7.1
Waist Hip Ratio (WHR) 0.0 0.2 0.2 -0.5 0.3
Systolic Blood Pressure 0.0 0.1 0.1 -0.1 0.4
Smoking Status 0.7 1.6 2.5 1.6 -0.9
Allergy or Eczema 0.6 1.5 2.4 1.6 -0.7
Cardiovascular Disease 0.3 0.9 0.9 0.9 -1.0
Hypothyroidism (self reported) 0.0 0.0 0.1 -0.2 0.2
Respiratory disease 0.2 0.5 0.6 0.8 -0.6
Type 2 Diabetes (T2D) (2018) 0.3 0.6 1.0 -1.0 0.4
Lung FEV1/FVC ratio 0.0 0.1 0.1 0.2 -0.4
Lung FVC 0.2 1.0 1.4 -1.2 0.8
Neuroticism 0.1 0.2 0.3 -0.6 0.3
Chronotype (morning person) 1.2 2.7 3.1 1.5 -1.8
Hair Pigment 0.0 0.8 1.1 0.7 -1.1
Tanning 0.5 5.8 6.9 2.6 -2.2
Hand grip strength (left) 0.0 0.1 0.1 -0.0 -0.4
Number of treatments/medications taken 0.3 0.6 0.7 -0.8 0.7
Average weekly spirits intake 0.4 0.5 0.6 -0.8 0.7
Sensitivity / hurt feelings 0.3 0.6 0.7 -0.7 0.8
Frequency of depressed mood in last 2 weeks 0.1 0.1 0.2 -0.2 0.5
Hearing difficulty/problems: Yes 0.0 0.0 0.1 -0.3 0.1
Relative age of first facial hair 2.0 4.2 4.3 2.1 -2.0
Other serious medical condition/disability diagnosed by doctor 0.1 0.1 0.2 0.4 0.3
Ever used hormone-replacement therapy (HRT) 0.5 0.6 0.8 0.9 -0.7
Ever had hysterectomy (womb removed) 0.4 0.5 0.5 0.6 -0.7
Systolic blood pressure, automated reading 0.8 2.2 2.6 -1.4 1.6
Eye problems/disorders: Diabetes related eye disease 0.0 0.0 0.1 0.1 0.3
Angina 0.1 0.1 0.2 0.4 0.3
Medication for hormone replacement therapy 0.4 0.5 0.7 -0.5 0.9
Vitamin and mineral supplements 0.4 0.6 0.9 0.5 -0.9
Supplements: Zinc 0.1 0.1 0.1 0.3 -0.3
Medication: Co-codamol 0.1 0.1 0.1 -0.3 0.4
Medication: Metformin 0.0 0.1 0.1 -0.3 -0.1
Diabetes (father) 0.3 0.4 0.4 -0.7 0.6
Diabetes (mother) 1.1 1.4 1.8 0.9 -1.4
Severe depression (siblings) 0.0 0.0 0.0 -0.1 -0.1
Pack years adult smoking proportion 0.1 0.2 0.3 -0.3 0.6
Impedance of leg (right) 0.5 2.6 3.3 1.8 -1.4
Leg fat-free mass (left) 2.1 11.1 11.3 -3.4 3.3
Trunk fat percentage 0.8 3.4 3.8 -1.7 1.9
Hand grip strength (right) 0.0 0.1 0.1 -0.3 -0.4
Townsend deprivation index at recruitment 0.3 0.4 0.5 0.7 0.6
Current tobacco smoking 0.1 0.1 0.1 0.4 -0.2
Average weekly fortified wine intake 0.0 0.0 0.0 0.2 0.1
Maternal smoking around birth 1.5 2.2 2.5 1.4 -1.6
Fed-up feelings 0.1 0.2 0.3 -0.5 0.4
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 0.9 1.1 -0.9 1.0
Relative age voice broke 0.3 0.5 0.6 0.6 -0.8
Taking other prescription medications 0.8 1.2 1.3 -1.1 1.1
Age when periods started (menarche) 0.0 0.0 0.0 0.2 -0.2
Bilateral oophorectomy (both ovaries removed) 0.1 0.1 0.2 0.3 -0.5
Heel bone mineral density (BMD) T-score, automated (left) 0.7 1.7 1.9 1.4 -1.2
Tinnitus: Yes, but not now, but have in the past 0.6 0.7 1.1 1.0 -0.6
Qualifications: CSEs or equivalent 4.4 5.8 5.8 -2.4 2.4
Serious illness, injury or assault to yourself 2.9 3.5 4.2 -1.6 2.1
High blood pressure 0.1 0.4 0.6 0.8 -0.5
Hayfever, allergic rhinitis or eczema 0.9 2.0 2.4 1.5 -1.3
Multivitamins +/- minerals 0.1 0.1 0.2 0.2 0.4
Stomach or abdominal pain in last month 0.5 0.6 1.0 1.0 -0.4
Supplements: Glucosamine 0.7 0.9 1.8 -1.3 0.3
Diverticular disease/diverticulitis (self-reported) 0.1 0.1 0.3 0.5 0.1
Medication: Atenolol 0.0 0.1 0.1 -0.3 0.0
Medication: Levothyroxine sodium 0.2 0.3 0.4 -0.6 0.4
Sitting height 1.4 10.2 10.9 -3.1 3.3
Chronic bronchitis/emphysema (father) 2.3 2.7 3.7 -1.9 1.3
High blood pressure (mother) 0.0 0.0 0.1 0.3 0.0
Body mass index (BMI) 0.3 1.2 1.3 -1.1 1.0
Impedance of leg (left) 0.3 1.5 1.9 1.4 -1.1
Leg predicted mass (left) 2.1 11.2 11.4 -3.4 3.3
Trunk fat mass 1.4 5.9 6.4 -2.3 2.5
Waist circumference 1.1 4.0 4.2 -1.9 2.1
Number of incorrect matches in round 0.0 0.0 0.0 0.1 0.1
Past tobacco smoking 0.5 0.8 1.3 0.6 -1.1
Alcohol usually taken with meals 0.4 0.6 0.7 -0.8 0.7
Nervous feelings 2.0 3.8 4.8 -2.2 1.6
Frequency of tenseness / restlessness in last 2 weeks 0.8 1.3 1.4 -1.2 1.1
Hearing difficulty/problems with background noise 1.8 2.9 4.1 2.0 -1.3
Hair/balding pattern: Pattern 2 0.8 1.0 1.8 -0.5 1.3
Had menopause 0.3 0.4 0.6 0.4 -0.8
Had other major operations 0.9 1.1 1.2 1.1 -0.9
Forced vital capacity (FVC) 0.5 2.1 2.5 -1.6 1.3
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.6 0.7 0.8 -0.8
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 0.8 0.7 -0.9
Qualifications: None of the above 1.0 2.2 2.3 1.5 -1.4
Financial difficulties in last 2 years 0.4 0.6 0.7 -0.9 0.7
Mouth/teeth dental problems 0.0 0.1 0.1 -0.3 0.1
Heart attack 0.3 0.4 0.4 -0.6 0.6
Allergy 0.2 0.4 0.7 -0.9 0.4
Pain all over the body in last month 0.2 0.2 0.3 0.5 -0.5
Diabetes (self-reported) 1.1 1.8 2.2 -1.5 1.1
Hayfever/allergic rhinitis (self-reported) 1.0 1.3 1.6 -1.0 1.3
Medication: Ramipril 1.5 2.0 2.5 -1.2 1.6
Medication: Simvastatin 0.0 0.0 0.1 -0.2 0.1
Fluid intelligence score 0.2 0.5 0.5 0.7 -0.7
Illnesses of siblings 0.0 0.0 0.0 -0.1 -0.0
Neuroticism score 0.3 0.6 0.8 -0.9 0.5
Weight 1.7 8.4 8.6 -2.9 2.9
Impedance of arm (right) 0.3 1.4 2.2 -0.8 1.5
Arm fat percentage (right) 0.6 2.3 2.8 -1.3 1.7
Trunk fat-free mass 1.7 9.9 10.4 -3.2 3.1
Hip circumference 1.0 4.4 5.0 -2.0 2.2
Time employed in main current job 0.2 0.3 0.4 0.3 -0.6
Alcohol intake versus 10 years previously 1.0 1.5 2.4 -0.9 1.5
Father’s age at death 1.4 1.8 2.9 0.9 -1.7
Worrier / anxious feelings 0.0 0.0 0.0 -0.1 -0.2
Frequency of tiredness / lethargy in last 2 weeks 1.2 2.0 2.4 -1.2 1.6
Falls in the last year 1.2 1.6 2.6 -0.7 1.6
Hair/balding pattern: Pattern 3 0.1 0.1 0.2 -0.2 -0.4
Number of live births 0.0 0.0 0.0 -0.0 -0.2
Forced expiratory volume in 1-second (FEV1) 0.6 1.9 2.6 -1.6 1.1
Pulse rate 0.9 1.6 1.9 -1.4 1.1
Happiness 0.9 1.1 1.9 -0.6 1.4
Noisy workplace 0.3 0.4 0.7 0.1 0.8
Qualifications: A levels/AS levels or equivalent 0.8 1.7 1.9 -1.4 1.2
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.5 0.8 -0.4 0.9
Mouth/teeth dental problems: Dentures 2.1 3.5 3.8 2.0 -1.8
Asthma 0.0 0.0 0.0 -0.2 0.2
Medication: Ibuprofen (e.g. Nurofen) 1.0 1.3 2.4 -0.4 1.6
Medication: Cholesterol lowering 0.4 0.6 0.7 -0.8 0.8
Depression (self-reported) 2.5 3.0 3.8 -1.5 1.9
Medication: Lansoprazole 0.1 0.2 0.3 0.0 0.6
Prospective memory result 3.6 4.4 5.5 2.3 -1.8
Lung cancer (father) 0.3 0.3 0.3 0.6 -0.5
Illnesses of mother 0.2 0.2 0.4 -0.6 -0.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.5 1.5 1.9 -1.4 1.1
Pulse wave Arterial Stiffness index 0.1 0.2 0.3 -0.5 -0.3
Impedance of arm (left) 0.5 2.2 3.0 -1.2 1.7
Arm fat mass (right) 0.9 3.6 3.7 -1.9 1.9
Trunk predicted mass 1.7 9.7 10.2 -3.2 3.0
Standing height 1.8 17.6 18.2 -4.1 4.3
Length of working week for main job 0.1 0.2 0.3 -0.1 0.6
Exposure to tobacco smoke at home 0.1 0.1 0.2 -0.2 0.5
Breastfed as a baby 1.8 2.2 3.1 -1.1 1.8
Tense / ‘highly strung’ 0.7 1.2 1.6 -1.3 0.9
Seen doctor (GP) for nerves, anxiety, tension or depression 0.1 0.1 0.3 -0.1 0.5
Hair/balding pattern: Pattern 4 0.0 0.0 0.0 -0.1 -0.1
Birth weight of first child 7.8 14.2 15.0 -3.7 3.9
Peak expiratory flow (PEF) 0.1 0.2 0.4 0.2 -0.6
Pulse wave reflection index 0.0 0.0 0.0 0.0 -0.2
Ever highly irritable/argumentative for 2 days 0.7 0.8 0.9 0.9 -0.8
Loud music exposure frequency 0.1 0.1 0.1 0.3 -0.1
Qualifications: O levels/GCSEs or equivalent 3.2 5.0 5.8 -2.4 2.1
Mouth/teeth dental problems: Bleeding gums 4.9 6.3 6.6 -2.6 2.5
Blood clot in the leg (DVT) 0.2 0.3 0.4 -0.5 0.6
Medication: Paracetamol 3.3 5.4 7.0 -1.9 2.7
Headache pain in last month 1.9 3.3 3.7 -1.7 1.9
Medication for cholesterol, blood pressure or diabetes 0.8 1.3 1.5 1.2 -1.0
Glaucoma (self-reported) 1.0 1.2 1.9 0.6 -1.4
Gout (self-reported) 0.2 0.3 0.5 0.2 0.7
Hypothyroidism/myxoedema (self-reported) 0.4 0.8 1.0 -0.8 1.0
Medication: Amlodipine 0.5 0.7 0.8 0.9 -0.8
Medication: Ventolin 100micrograms inhaler 0.4 0.5 0.9 1.0 -0.2
Birth weight 6.8 14.7 17.2 -3.5 4.1
Chronic bronchitis/emphysema (mother) 1.1 1.3 2.2 -0.7 1.5
High blood pressure (siblings) 0.4 0.5 0.6 -0.6 0.8
Forced vital capacity (FVC), Best measure 0.3 1.2 1.3 -1.1 1.0
Body fat percentage 0.5 2.0 2.3 -1.3 1.5
Leg fat percentage (right) 0.1 0.2 0.3 -0.4 0.6
Arm fat-free mass (right) 1.2 6.3 7.2 -2.7 2.3
Exposure to tobacco smoke outside home 3.0 4.0 4.1 -2.0 2.0
Comparative body size at age 10 3.3 9.0 9.6 -2.9 3.1
Number of full brothers 2.6 3.2 3.5 1.9 -1.7
Worry too long after embarrassment 0.0 0.0 0.0 0.1 -0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 0.7 -0.4 0.9
Wheeze or whistling in the chest in last year 0.1 0.2 0.3 -0.3 0.5
Number of children fathered 1.4 1.6 2.3 1.5 -0.9
Reason for reducing amount of alcohol drunk: Health precaution 0.9 1.1 1.3 -1.1 1.0
Age at first live birth 0.0 0.0 0.1 -0.0 -0.3
Pulse wave peak to peak time 0.1 0.1 0.2 0.3 0.4
Health satisfaction 2.4 3.2 3.2 -1.8 1.8
Shortness of breath walking on level ground 0.6 0.7 1.0 1.0 -0.7
Qualifications: College or University degree 0.1 0.2 0.2 -0.5 -0.4
Eye problems/disorders: None of the above 5.3 6.2 7.1 -2.7 2.3
Mouth/teeth dental problems: Loose teeth 0.7 0.8 1.3 -1.2 0.5
Emphysema/chronic bronchitis 0.4 0.4 0.8 0.9 -0.1
Medication for pain relief, constipation, heartburn 0.2 0.3 0.6 0.2 -0.8
Neck or shoulder pain in last month 0.1 0.1 0.3 -0.0 0.5
Medication: Blood pressure 0.5 0.8 0.9 -1.0 0.9
Angina (self-reported) 0.1 0.1 0.1 0.3 0.3
Migraine (self-reported) 0.4 0.5 0.9 -0.9 0.4
Medication: Ibuprofen 0.6 0.7 1.3 -0.1 1.2
Medication: Allopurinol 0.1 0.2 0.3 0.2 0.6
Medication: Omeprazole 0.2 0.2 0.4 -0.0 -0.7
Medication: Seretide 50 evohaler 0.5 0.5 1.0 1.0 -0.3
Mean time to correctly identify matches 1.5 2.9 3.5 -1.5 1.9
Heart disease (mother) 0.3 0.3 0.7 -0.1 0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.5 0.9 -0.9 0.4
Whole body fat mass 0.9 3.9 4.3 -1.9 2.1
Leg fat mass (right) 0.7 2.6 2.8 -1.5 1.7
Arm predicted mass (right) 1.4 7.2 8.2 -2.9 2.5
Pulse rate, automated reading 0.9 2.9 3.0 -1.7 1.7
Alcohol intake frequency. 0.5 1.2 1.5 -0.9 1.2
Comparative height size at age 10 1.9 10.3 10.7 -3.3 3.1
Number of full sisters 0.9 1.1 1.2 1.1 -1.0
Suffer from ‘nerves’ 1.3 2.1 2.9 -1.7 1.1
Overall health rating 3.4 7.2 8.6 -2.4 2.9
Chest pain or discomfort 0.4 0.6 0.7 -0.7 0.8
Had major operations 0.5 0.6 0.8 -0.6 0.9
Age at last live birth 1.0 1.5 1.8 -1.3 1.1
Family relationship satisfaction 0.2 0.2 0.2 -0.5 0.4
Leg pain on walking 1.6 2.0 2.3 -1.3 1.5
Qualifications: NVQ or HND or HNC or equivalent 0.0 0.0 0.1 -0.1 0.2
Commuting to job workplace: Car/motor vehicle 1.5 1.8 1.9 1.4 -1.3
Illness, injury, bereavement, stress in last 2 years 1.1 1.4 1.6 1.1 -1.2
Medication: Aspirin 0.4 0.5 0.6 0.5 -0.8
Supplements: Vitamin C 0.2 0.2 0.4 -0.6 0.2
Knee pain experienced in last month 0.3 0.5 0.6 -0.5 0.8
Hypertension (Self-reported) 0.1 0.3 0.6 0.8 -0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.5 1.0 1.0 -0.2
Illnesses of father: Heart disease 0.1 0.1 0.2 0.3 -0.4
Illnesses of siblings: Diabetes 0.1 0.1 0.1 0.0 -0.4
Smoking status: Previous 0.1 0.1 0.2 -0.1 0.5
Forced expiratory volume in 1-second (FEV1), predicted 1.2 2.6 2.6 -1.6 1.6
Whole body fat-free mass 1.9 11.0 11.8 -3.4 3.2
Leg fat-free mass (right) 2.4 12.6 13.2 -3.6 3.5
Arm fat percentage (left) 0.8 3.3 3.8 -1.7 1.9
Average weekly red wine intake 0.5 0.7 1.0 -1.0 0.7
Handedness (chirality/laterality): Left-handed 3.4 4.1 5.2 -1.7 2.3
Mood swings 0.8 1.5 2.4 0.8 -1.5
Loneliness, isolation 0.2 0.3 0.6 0.8 -0.2
Long-standing illness, disability or infirmity 0.5 0.7 0.9 0.9 -0.8
Ever had bowel cancer screening 0.1 0.1 0.2 0.5 -0.1
Diabetes diagnosed by doctor 2.3 3.8 4.7 -2.2 1.7
Ever had stillbirth, spontaneous miscarriage or termination 1.4 1.5 2.0 1.4 -1.1
Friendships satisfaction 0.4 0.4 0.6 0.8 -0.5
Qualifications: nursing, teaching 0.0 0.1 0.1 -0.1 -0.3
Commuting to job workplace: Walk 2.2 2.4 3.2 -1.2 1.8
Eye problems/disorders: Cataract 5.7 6.6 6.9 2.6 -2.5
Mouth/teeth dental problems: Mouth ulcers 0.5 0.7 0.9 0.8 -0.9
Medication for cholesterol 0.0 0.0 0.1 -0.2 -0.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.9 2.3 2.6 1.6 -1.4
Back pain experienced in last month 0.2 0.3 0.6 0.8 -0.0
Mineral and other dietary supplements 0.7 1.0 1.1 1.0 -0.9
Breast cancer (self-reported) 1.1 1.3 1.8 -1.3 0.9
Asthma (self-reported) 0.0 0.0 0.0 -0.1 0.0
Osteoporosis (self-reported) 0.5 0.6 1.1 1.1 -0.1
Osteoarthritis (self-reported) 0.3 0.4 0.7 -0.3 0.9
Medication: Aspirin 0.3 0.3 0.6 0.3 -0.8
Medication: Gliclazide 1.3 1.5 1.5 -1.2 1.2
Illnesses of father: None of the above (group 1) 0.9 1.1 1.6 1.2 -0.8
Smoking status: Current 0.0 0.1 0.1 0.3 -0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.7 1.4 1.9 1.0 -1.4
Whole body water mass 1.9 10.6 11.4 -3.4 3.1
Leg predicted mass (right) 2.3 12.0 12.7 -3.6 3.4
Arm fat mass (left) 1.0 4.2 4.4 -2.1 2.0
Number of self-reported non-cancer illnesses 0.0 0.1 0.1 0.3 0.2
Average weekly champagne plus white wine intake 0.7 0.9 1.4 0.6 -1.2
Miserableness 0.1 0.2 0.3 -0.4 0.5
Guilty feelings 1.1 1.6 1.7 -1.2 1.3
Wears glasses or contact lenses 1.3 1.6 2.0 -1.1 1.4
Ever taken oral contraceptive pill 0.2 0.2 0.2 0.5 -0.4
Hearing aid user 0.1 0.1 0.1 0.3 -0.2
Mother’s age at death 1.5 1.9 2.0 1.4 -1.3
Financial situation satisfaction 1.0 1.2 1.4 -1.0 1.2
Tinnitus: Yes, now most or all of the time 0.0 0.0 0.0 -0.1 0.2
Commuting to job workplace: Public transport 1.9 2.3 2.9 1.7 -1.3
Eye problems/disorders: Glaucoma 0.3 0.4 0.5 0.6 -0.7
Medication: Blood pressure 0.8 1.5 1.8 1.3 -1.1
Pain type(s) experienced in last month: Hip pain 2.4 3.1 3.8 1.5 -1.9
Supplements: Fish oil (including cod liver oil) 0.1 0.1 0.1 -0.2 0.4
High cholesterol (Self-reported) 0.1 0.1 0.2 0.4 -0.4
Medication: Bendroflumethiazide 1.2 1.8 2.0 1.4 -1.2
Medication: Paracetamol 2.0 3.2 3.8 -1.6 2.0
Medication: Lisinopril 0.2 0.3 0.3 0.5 -0.6
Medication: Atorvastatin 2.2 2.8 3.3 -1.8 1.5
Illnesses of father: High blood pressure 2.4 2.9 3.7 1.9 -1.4
Alcohol drinker status: Never 0.1 0.1 0.2 -0.5 -0.2
Ever smoked 0.7 1.3 2.0 -0.7 1.4
Basal metabolic rate 1.7 9.4 9.9 -3.1 3.0
Leg fat percentage (left) 0.2 0.6 0.6 -0.7 0.8
Arm fat-free mass (left) 1.3 6.8 7.7 -2.8 2.4
Number of operations (self-reported) 0.1 0.2 0.3 -0.3 0.5
Average weekly beer plus cider intake 0.0 0.0 0.0 -0.2 -0.1
Irritability 0.4 0.7 1.1 -1.1 0.4
Risk taking 0.2 0.3 0.4 0.6 -0.4
Ever had prostate specific antigen (PSA) test 0.1 0.1 0.3 -0.1 -0.5
Fractured/broken bones in last 5 years 3.9 5.1 5.8 2.4 -2.1
Age started oral contraceptive pill 2.3 2.9 3.4 -1.8 1.5
Diastolic blood pressure, automated reading 3.4 10.7 11.1 -3.3 3.2
Ever depressed for a whole week 0.0 0.1 0.1 0.3 -0.2
Unable to work because of sickness or disability 0.1 0.1 0.1 0.3 -0.2
Commuting to job workplace: Cycle 0.1 0.1 0.2 -0.3 0.4
Myopia 0.2 0.3 0.4 0.5 -0.6
Vascular/heart problems diagnosed by doctor 0.1 0.2 0.3 -0.5 0.4
Cholesterol lowering medication 0.2 0.2 0.4 -0.6 0.2
Medication: Omeprazole (e.g. Zanprol) 0.2 0.3 0.5 0.1 -0.7
Pain experienced in last month 0.3 0.5 0.8 -0.9 0.5
Supplements: Calcium 0.1 0.1 0.2 0.0 0.4
Basal cell carcinoma (self-reported) 0.8 0.9 1.1 -1.0 0.8
Heart attack/myocardial infarction (self-reported) 0.6 0.8 1.0 -0.8 1.0
Deep venous thrombosis (DVT) (self-reported) 0.1 0.2 0.2 -0.4 0.5
Heart disease (siblings) 0.4 0.5 0.6 0.8 -0.5
Alcohol drinker status: Previous 0.2 0.3 0.5 0.7 -0.0
Pack years of smoking 0.3 0.4 0.6 -0.5 0.7
Impedance of whole body 0.0 0.1 0.2 -0.1 0.5
Leg fat mass (left) 0.8 3.1 3.3 -1.7 1.8
Arm predicted mass (left) 0.9 4.8 5.3 -2.3 2.1