Hub : Genes

SPRYD7

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.068 0.024 1.2e-04 0.062 0.038 0.053 0.052 0.067 4.7e-08 1.7e-05 4.8e-07 5.9e-07 1.5e-08
2 GTEx Brain Cerebellar Hemisphere 0.456 0.105 6.4e-05 0.157 NA 0.160 NA 0.173 8.0e-05 NA 6.7e-05 NA 3.4e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.2 0.4 0.7 0.3 -0.8
Bipolar Disorder or Schizophrenia 0.3 0.7 1.4 -1.2 -0.2
Depressed Affect (Nagel 2018) 0.2 0.5 0.7 0.5 -0.8
Depression (Nagel 2018) 1.2 1.9 2.8 -1.7 1.0
Intelligence (Savage-Jansen 2018) 0.0 0.2 0.3 -0.1 -0.5
Neuroticism (Nagel 2018) 0.2 0.4 0.7 0.3 -0.9
Schizophrenia (2018) 0.7 1.5 2.9 -1.7 0.3
Schizophrenia vs Biploar Disorder 6.5 8.5 9.1 -3.0 2.8
Worry (Nagel 2018) 1.4 3.0 4.1 1.4 -2.0
Alzheimer’s Disease (in mother) 0.3 0.3 0.6 -0.8 0.2
Alzheimer’s Disease (in father) 2.7 3.0 3.7 1.9 -1.5
Alzheimer’s Disease (including proxy) 0.9 1.3 1.3 1.1 -1.1
Crohns Disease (2017) 0.0 0.1 0.1 -0.1 -0.4
Irritable Bowel Disease (IBD) 0.4 0.9 1.1 -1.1 0.9
Ulcerative Colitis (UC) 1.2 2.2 2.3 -1.5 1.5
Major Depression (MDD) 0.3 0.3 0.6 -0.8 0.2
Reaction Time 1.7 3.2 3.9 -2.0 1.6
Verbal and Numeric Reasoning (VNR) 0.2 0.4 0.9 -0.9 -0.0
Breast Cancer 0.7 1.6 2.3 0.9 -1.5
Ovarian Cancer 0.4 0.5 0.7 -0.8 0.6
Prostate Cancer 0.1 0.1 0.2 0.2 -0.4
Age at First Birth 0.2 0.4 0.6 0.3 -0.8
Bipolar Disorder (2011) 0.3 0.3 0.6 -0.8 0.1
Body Mass Index (BMI) (2010) 3.1 4.3 5.3 -2.3 1.8
Coronary Artery Disease (CAD) 0.2 0.3 0.3 -0.5 0.5
Crohns Disease (2012) 0.3 0.4 0.6 -0.5 0.8
Mean Putamen Volume 0.4 0.4 0.4 0.7 -0.7
Fasting Glucose 0.6 0.7 0.8 0.8 -0.9
HbA1C 0.0 0.0 0.0 -0.1 0.1
HDL Cholesterol 0.1 0.2 0.3 0.6 0.0
LDL Cholesterol 0.5 0.9 1.6 0.3 -1.3
Lupus 3.6 5.4 7.0 -2.0 2.6
Neuroticism (2016) 2.2 3.2 4.0 -2.0 1.5
Primary Biliary Cirrhosis 1.5 2.1 3.0 -1.1 1.7
Rheumatoid Arthritis 1.0 1.4 2.5 1.6 -0.6
Schizophrenia (2014) 2.2 4.8 7.5 -2.7 1.4
Triglycerides 0.1 0.1 0.2 -0.5 -0.1
Type 2 Diabetes (T2D) (2012) 0.2 0.2 0.4 -0.7 0.0
Ulcerative Colitis 1.9 2.7 3.0 -1.6 1.7
Blood Eosinophil Count 0.3 2.2 2.7 1.6 1.3
Blood Platelet Count 0.6 6.5 11.1 -1.4 3.3
Blood Red Count 0.0 0.2 0.3 -0.0 0.5
Blood White Count 0.0 0.0 0.1 0.3 -0.0
Heel T-Score 2.3 18.3 26.7 5.2 -3.1
BMI 0.4 2.4 3.4 -1.2 1.8
Height 1.1 21.3 38.9 -6.2 1.9
Waist Hip Ratio (WHR) 0.2 0.8 1.4 -1.2 0.5
Systolic Blood Pressure 1.3 6.6 7.4 2.7 -2.4
Smoking Status 1.1 2.7 3.2 1.8 -1.5
Allergy or Eczema 1.8 4.8 5.5 -2.3 2.0
Cardiovascular Disease 3.7 12.2 13.4 3.3 -3.7
Hypothyroidism (self reported) 1.2 2.7 3.6 -1.3 1.9
Respiratory disease 2.8 6.1 7.8 -2.1 2.8
Type 2 Diabetes (T2D) (2018) 1.0 1.9 2.9 1.7 -0.9
Lung FEV1/FVC ratio 1.3 6.8 9.5 3.1 -2.0
Lung FVC 1.6 8.2 9.1 -3.0 2.7
Neuroticism 0.1 0.2 0.5 0.1 -0.7
Chronotype (morning person) 0.0 0.0 0.1 -0.3 0.1
Hair Pigment 0.0 1.3 1.9 1.4 0.8
Tanning 0.1 1.1 1.4 0.9 -1.2
Hand grip strength (left) 0.4 1.0 1.9 -0.2 -1.4
Number of treatments/medications taken 0.0 0.0 0.0 -0.2 0.1
Average weekly spirits intake 0.4 0.4 0.7 -0.4 -0.8
Sensitivity / hurt feelings 0.2 0.4 0.7 0.2 -0.9
Frequency of depressed mood in last 2 weeks 1.2 1.6 1.9 -1.4 1.2
Hearing difficulty/problems: Yes 0.1 0.1 0.1 -0.2 0.4
Relative age of first facial hair 1.2 2.5 3.3 -1.8 1.3
Other serious medical condition/disability diagnosed by doctor 0.8 1.1 1.7 -1.3 0.7
Ever used hormone-replacement therapy (HRT) 1.8 2.2 2.6 1.6 -1.4
Ever had hysterectomy (womb removed) 2.1 2.3 2.9 1.7 -1.3
Systolic blood pressure, automated reading 1.2 3.4 4.4 2.1 -1.6
Eye problems/disorders: Diabetes related eye disease 0.8 0.8 1.5 -0.4 1.2
Angina 2.3 3.0 3.7 1.9 -1.5
Medication for hormone replacement therapy 1.2 1.3 2.4 1.5 -0.5
Vitamin and mineral supplements 1.5 2.0 2.1 1.4 -1.4
Supplements: Zinc 2.8 3.0 3.8 -1.5 1.9
Medication: Co-codamol 3.5 4.0 4.8 2.2 -1.8
Medication: Metformin 0.0 0.0 0.1 0.1 0.3
Diabetes (father) 4.1 5.0 7.8 -1.5 2.8
Diabetes (mother) 0.0 0.1 0.1 -0.1 0.3
Severe depression (siblings) 0.2 0.2 0.2 -0.4 -0.5
Pack years adult smoking proportion 3.1 4.8 6.4 2.5 -1.8
Impedance of leg (right) 3.6 17.6 18.1 -4.3 4.1
Leg fat-free mass (left) 0.2 1.0 1.9 -1.4 0.3
Trunk fat percentage 3.8 15.0 15.9 -4.0 3.8
Hand grip strength (right) 0.1 0.4 0.8 -0.2 -0.9
Townsend deprivation index at recruitment 0.1 0.1 0.2 -0.0 -0.4
Current tobacco smoking 4.1 6.8 7.6 2.8 -2.4
Average weekly fortified wine intake 0.2 0.3 0.5 -0.7 0.1
Maternal smoking around birth 0.1 0.2 0.3 0.6 0.3
Fed-up feelings 0.1 0.2 0.2 -0.5 0.4
Frequency of unenthusiasm / disinterest in last 2 weeks 1.5 2.0 3.0 -1.7 1.0
Relative age voice broke 0.2 0.3 0.6 0.2 -0.8
Taking other prescription medications 1.4 2.2 2.8 -1.7 1.2
Age when periods started (menarche) 1.0 2.5 4.2 0.9 -2.0
Bilateral oophorectomy (both ovaries removed) 0.3 0.4 0.5 0.5 -0.7
Heel bone mineral density (BMD) T-score, automated (left) 1.1 2.4 4.6 2.1 -0.5
Tinnitus: Yes, but not now, but have in the past 0.1 0.1 0.2 -0.5 0.2
Qualifications: CSEs or equivalent 0.4 0.5 0.9 0.4 0.9
Serious illness, injury or assault to yourself 0.3 0.3 0.6 0.1 0.8
High blood pressure 4.0 11.1 12.0 3.2 -3.5
Hayfever, allergic rhinitis or eczema 0.5 1.1 1.1 -1.1 1.0
Multivitamins +/- minerals 0.0 0.0 0.1 0.3 0.1
Stomach or abdominal pain in last month 1.4 1.7 2.3 -1.1 1.5
Supplements: Glucosamine 0.0 0.1 0.1 0.2 0.2
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 0.2 -0.5 0.4
Medication: Atenolol 0.8 1.0 1.2 0.8 -1.1
Medication: Levothyroxine sodium 0.9 1.5 2.4 -0.8 1.5
Sitting height 0.2 1.6 1.9 -1.2 -1.4
Chronic bronchitis/emphysema (father) 1.2 1.4 1.9 -1.4 0.9
High blood pressure (mother) 0.3 0.4 0.7 0.8 -0.2
Body mass index (BMI) 0.7 3.1 4.1 -1.5 2.0
Impedance of leg (left) 2.2 10.5 10.7 -3.2 3.3
Leg predicted mass (left) 0.2 1.0 2.0 -1.4 0.3
Trunk fat mass 3.9 16.6 18.7 -4.3 3.8
Waist circumference 1.6 5.9 6.4 -2.5 2.3
Number of incorrect matches in round 7.4 12.3 14.6 -3.8 3.2
Past tobacco smoking 0.0 0.0 0.0 0.1 0.2
Alcohol usually taken with meals 0.0 0.0 0.0 0.2 0.1
Nervous feelings 0.5 0.9 1.8 0.4 -1.3
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.6 1.1 -1.0 0.5
Hearing difficulty/problems with background noise 1.1 1.7 2.0 1.2 -1.4
Hair/balding pattern: Pattern 2 0.6 0.8 1.2 1.1 -0.6
Had menopause 3.3 4.2 4.5 2.0 -2.1
Had other major operations 1.4 1.7 2.2 -1.1 1.5
Forced vital capacity (FVC) 2.5 9.4 13.9 -3.7 2.2
Heel bone mineral density (BMD) T-score, automated (right) 0.8 1.9 3.6 1.9 -0.4
Ever unenthusiastic/disinterested for a whole week 0.3 0.3 0.6 -0.2 -0.8
Qualifications: None of the above 0.0 0.0 0.0 0.1 -0.0
Financial difficulties in last 2 years 1.2 1.6 2.2 -1.0 1.5
Mouth/teeth dental problems 0.4 0.6 0.9 0.6 -0.9
Heart attack 0.7 0.8 1.0 -1.0 0.8
Allergy 1.2 2.8 3.0 1.7 -1.6
Pain all over the body in last month 0.8 0.8 0.8 -0.9 0.9
Diabetes (self-reported) 1.0 1.6 2.8 1.7 -0.6
Hayfever/allergic rhinitis (self-reported) 1.0 1.3 1.7 -1.0 1.3
Medication: Ramipril 0.3 0.4 0.6 0.8 -0.3
Medication: Simvastatin 0.9 1.4 1.8 1.0 -1.3
Fluid intelligence score 0.3 0.5 1.1 -1.0 0.1
Illnesses of siblings 0.1 0.1 0.2 0.4 -0.2
Neuroticism score 0.8 1.7 2.2 1.1 -1.5
Weight 1.8 8.9 11.1 -3.3 2.6
Impedance of arm (right) 0.6 2.6 4.1 -2.0 1.0
Arm fat percentage (right) 2.5 10.0 10.0 -3.2 3.2
Trunk fat-free mass 0.4 2.1 3.9 -2.0 0.5
Hip circumference 1.1 4.7 5.2 -2.3 2.0
Time employed in main current job 0.2 0.3 0.4 -0.7 0.3
Alcohol intake versus 10 years previously 0.2 0.4 0.4 -0.6 0.6
Father’s age at death 0.9 1.2 1.6 -0.9 1.3
Worrier / anxious feelings 0.5 1.0 1.5 0.7 -1.2
Frequency of tiredness / lethargy in last 2 weeks 0.0 0.1 0.1 -0.3 0.2
Falls in the last year 1.2 1.6 2.3 -1.5 0.9
Hair/balding pattern: Pattern 3 0.4 0.7 0.8 -0.9 0.7
Number of live births 3.3 4.6 4.7 2.1 -2.2
Forced expiratory volume in 1-second (FEV1) 1.5 5.0 7.1 -2.7 1.7
Pulse rate 0.3 0.4 0.5 0.7 -0.6
Happiness 0.0 0.0 0.0 0.2 -0.1
Noisy workplace 3.0 3.7 4.3 -1.8 2.1
Qualifications: A levels/AS levels or equivalent 0.0 0.1 0.1 -0.3 -0.3
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.5 0.8 -0.9 0.4
Mouth/teeth dental problems: Dentures 0.4 0.6 0.8 0.9 -0.6
Asthma 0.8 1.6 2.1 -1.1 1.4
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.4 0.6 -0.8 0.4
Medication: Cholesterol lowering 0.4 0.7 1.1 0.4 -1.1
Depression (self-reported) 0.3 0.4 0.7 -0.9 0.2
Medication: Lansoprazole 1.5 1.8 2.0 -1.2 1.4
Prospective memory result 0.3 0.4 0.7 0.8 -0.2
Lung cancer (father) 0.0 0.0 0.0 0.2 -0.1
Illnesses of mother 0.5 0.6 1.0 0.4 -1.0
Forced expiratory volume in 1-second (FEV1), Best measure 3.0 9.5 11.5 -3.4 2.7
Pulse wave Arterial Stiffness index 0.3 0.4 0.5 0.4 -0.7
Impedance of arm (left) 0.3 1.4 2.4 -1.5 0.7
Arm fat mass (right) 2.2 9.1 9.5 -3.1 2.9
Trunk predicted mass 0.4 2.4 4.4 -2.1 0.6
Standing height 1.0 9.9 18.0 -4.2 1.4
Length of working week for main job 0.3 0.3 0.4 0.5 -0.6
Exposure to tobacco smoke at home 0.4 0.4 0.5 -0.7 0.5
Breastfed as a baby 0.0 0.0 0.0 -0.1 0.2
Tense / ‘highly strung’ 0.1 0.1 0.2 -0.1 -0.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.7 1.1 1.3 -1.2 0.9
Hair/balding pattern: Pattern 4 1.3 3.2 4.5 1.4 -2.1
Birth weight of first child 0.8 1.5 1.6 1.2 -1.3
Peak expiratory flow (PEF) 0.3 0.7 1.4 -1.2 0.0
Pulse wave reflection index 1.6 2.0 2.1 1.5 -1.4
Ever highly irritable/argumentative for 2 days 0.1 0.1 0.2 0.2 -0.5
Loud music exposure frequency 0.1 0.1 0.1 -0.3 0.4
Qualifications: O levels/GCSEs or equivalent 0.8 1.2 1.3 1.1 -1.1
Mouth/teeth dental problems: Bleeding gums 1.4 1.8 2.2 -1.2 1.5
Blood clot in the leg (DVT) 0.9 1.2 1.7 -1.3 0.8
Medication: Paracetamol 3.0 4.9 5.7 -2.4 2.0
Headache pain in last month 0.8 1.3 1.3 -1.2 1.1
Medication for cholesterol, blood pressure or diabetes 0.9 1.4 2.7 -0.4 1.6
Glaucoma (self-reported) 4.2 4.9 7.8 -2.8 1.4
Gout (self-reported) 0.0 0.0 0.0 -0.2 -0.1
Hypothyroidism/myxoedema (self-reported) 1.0 1.9 2.6 -1.1 1.6
Medication: Amlodipine 0.2 0.2 0.3 -0.6 0.4
Medication: Ventolin 100micrograms inhaler 0.1 0.1 0.1 0.3 0.3
Birth weight 1.1 2.4 3.1 1.3 -1.8
Chronic bronchitis/emphysema (mother) 0.3 0.4 0.5 0.5 -0.7
High blood pressure (siblings) 0.1 0.2 0.3 0.3 -0.6
Forced vital capacity (FVC), Best measure 3.9 14.3 18.5 -4.3 3.2
Body fat percentage 4.4 17.3 17.8 -4.1 4.2
Leg fat percentage (right) 6.1 22.0 24.1 -4.5 4.9
Arm fat-free mass (right) 0.4 2.2 3.5 -1.9 1.0
Exposure to tobacco smoke outside home 0.2 0.2 0.3 -0.5 0.5
Comparative body size at age 10 0.2 0.5 0.9 -0.3 1.0
Number of full brothers 1.8 2.2 2.6 1.6 -1.4
Worry too long after embarrassment 2.0 3.4 4.0 1.7 -2.0
Seen a psychiatrist for nerves, anxiety, tension or depression 6.0 7.7 7.8 -2.8 2.8
Wheeze or whistling in the chest in last year 0.0 0.0 0.1 0.1 -0.3
Number of children fathered 0.0 0.0 0.0 -0.1 -0.1
Reason for reducing amount of alcohol drunk: Health precaution 0.1 0.1 0.2 0.5 0.1
Age at first live birth 0.1 0.2 0.4 -0.0 -0.6
Pulse wave peak to peak time 0.7 0.8 0.9 -0.9 0.9
Health satisfaction 0.1 0.1 0.3 0.5 -0.2
Shortness of breath walking on level ground 0.3 0.4 0.7 0.0 0.8
Qualifications: College or University degree 0.5 1.6 2.8 -1.7 0.6
Eye problems/disorders: None of the above 2.1 2.4 2.9 1.7 -1.3
Mouth/teeth dental problems: Loose teeth 1.5 1.8 2.7 1.7 -0.9
Emphysema/chronic bronchitis 0.0 0.0 0.0 0.1 0.1
Medication for pain relief, constipation, heartburn 0.1 0.1 0.1 0.2 0.4
Neck or shoulder pain in last month 0.2 0.3 0.3 -0.6 0.5
Medication: Blood pressure 1.3 2.2 3.7 0.9 -1.9
Angina (self-reported) 1.3 1.8 2.1 1.5 -1.2
Migraine (self-reported) 0.1 0.1 0.1 -0.3 0.2
Medication: Ibuprofen 0.0 0.0 0.0 -0.1 0.2
Medication: Allopurinol 0.1 0.2 0.2 -0.5 0.4
Medication: Omeprazole 0.9 1.1 1.4 1.2 -0.9
Medication: Seretide 50 evohaler 0.3 0.3 0.5 -0.2 0.7
Mean time to correctly identify matches 1.8 3.5 5.0 -2.2 1.4
Heart disease (mother) 0.6 0.7 0.9 0.9 -0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.7 2.0 2.5 1.6 -1.2
Whole body fat mass 3.7 15.6 16.4 -4.1 3.8
Leg fat mass (right) 4.8 18.5 18.6 -4.3 4.3
Arm predicted mass (right) 0.3 1.7 2.6 -1.6 0.9
Pulse rate, automated reading 0.5 1.7 2.1 1.1 -1.5
Alcohol intake frequency. 0.2 0.5 0.9 0.9 -0.4
Comparative height size at age 10 0.4 2.2 4.3 -2.1 0.3
Number of full sisters 2.5 3.0 4.0 1.4 -2.0
Suffer from ‘nerves’ 0.7 1.1 1.4 0.9 -1.2
Overall health rating 0.0 0.1 0.1 0.3 -0.1
Chest pain or discomfort 0.1 0.1 0.1 0.1 0.4
Had major operations 0.1 0.1 0.2 0.1 -0.5
Age at last live birth 0.1 0.2 0.4 -0.6 -0.1
Family relationship satisfaction 3.4 4.2 5.8 -1.6 2.4
Leg pain on walking 0.2 0.3 0.3 0.5 0.6
Qualifications: NVQ or HND or HNC or equivalent 0.5 0.6 0.7 -0.8 0.7
Commuting to job workplace: Car/motor vehicle 14.9 17.1 18.8 -3.9 4.3
Illness, injury, bereavement, stress in last 2 years 0.8 1.0 1.1 1.0 -1.1
Medication: Aspirin 2.1 2.8 3.1 1.8 -1.6
Supplements: Vitamin C 4.6 5.4 5.7 -2.4 2.3
Knee pain experienced in last month 0.2 0.4 0.6 -0.4 0.8
Hypertension (Self-reported) 3.9 10.7 12.0 3.1 -3.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.4 0.4 -0.6 0.6
Illnesses of father: Heart disease 0.6 0.8 1.5 -1.2 0.3
Illnesses of siblings: Diabetes 0.2 0.2 0.5 0.1 0.7
Smoking status: Previous 0.4 0.6 0.7 -0.7 0.8
Forced expiratory volume in 1-second (FEV1), predicted 0.0 0.0 0.1 -0.3 -0.2
Whole body fat-free mass 0.2 1.4 2.6 -1.6 0.3
Leg fat-free mass (right) 0.0 0.2 0.3 -0.4 -0.6
Arm fat percentage (left) 2.1 8.4 8.8 -2.8 3.0
Average weekly red wine intake 0.5 0.8 1.5 -0.2 -1.2
Handedness (chirality/laterality): Left-handed 0.4 0.5 0.9 0.4 -0.9
Mood swings 0.1 0.2 0.3 -0.4 0.5
Loneliness, isolation 0.3 0.4 0.6 0.5 -0.8
Long-standing illness, disability or infirmity 0.6 0.8 1.4 -1.2 0.5
Ever had bowel cancer screening 2.0 2.4 3.1 -1.8 1.3
Diabetes diagnosed by doctor 0.5 0.7 1.3 1.2 -0.4
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.8 0.8 0.9 -0.9
Friendships satisfaction 4.1 5.1 6.1 -2.5 2.0
Qualifications: nursing, teaching 0.3 0.5 0.8 -0.9 0.5
Commuting to job workplace: Walk 5.4 5.8 7.0 2.1 -2.6
Eye problems/disorders: Cataract 1.1 1.2 1.4 -1.2 1.0
Mouth/teeth dental problems: Mouth ulcers 2.8 4.4 4.7 -2.0 2.2
Medication for cholesterol 3.5 5.2 8.4 -2.9 1.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 3.9 4.6 6.0 1.8 -2.5
Back pain experienced in last month 0.3 0.4 0.5 0.7 -0.5
Mineral and other dietary supplements 0.0 0.0 0.1 0.0 -0.3
Breast cancer (self-reported) 0.6 0.8 0.8 -0.9 0.9
Asthma (self-reported) 0.9 1.8 2.2 -1.1 1.5
Osteoporosis (self-reported) 0.1 0.2 0.3 -0.6 -0.2
Osteoarthritis (self-reported) 0.4 0.5 0.8 -0.4 0.9
Medication: Aspirin 1.9 2.4 3.0 1.7 -1.4
Medication: Gliclazide 1.7 1.9 2.7 1.6 -1.1
Illnesses of father: None of the above (group 1) 1.3 1.6 1.7 1.3 -1.3
Smoking status: Current 3.9 6.2 7.0 2.6 -2.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.7 3.5 3.9 -2.0 1.8
Whole body water mass 0.3 1.5 2.8 -1.7 0.4
Leg predicted mass (right) 0.0 0.2 0.3 -0.4 -0.5
Arm fat mass (left) 2.1 8.7 8.7 -2.9 2.9
Number of self-reported non-cancer illnesses 0.1 0.2 0.2 -0.4 0.4
Average weekly champagne plus white wine intake 1.0 1.4 1.4 -1.2 1.2
Miserableness 0.1 0.2 0.4 0.3 -0.6
Guilty feelings 0.0 0.1 0.1 0.0 -0.3
Wears glasses or contact lenses 0.2 0.3 0.4 -0.7 0.4
Ever taken oral contraceptive pill 1.2 1.3 2.4 1.6 -0.5
Hearing aid user 3.2 3.6 4.1 -1.7 2.0
Mother’s age at death 2.4 3.1 3.5 -1.6 1.9
Financial situation satisfaction 0.1 0.1 0.3 0.0 0.5
Tinnitus: Yes, now most or all of the time 0.9 1.1 1.1 1.0 -1.1
Commuting to job workplace: Public transport 2.3 2.7 3.4 1.4 -1.9
Eye problems/disorders: Glaucoma 4.3 5.1 7.3 -2.7 1.7
Medication: Blood pressure 2.6 4.9 6.8 2.6 -1.7
Pain type(s) experienced in last month: Hip pain 0.1 0.1 0.2 0.5 -0.0
Supplements: Fish oil (including cod liver oil) 0.6 0.8 1.0 0.8 -1.0
High cholesterol (Self-reported) 1.9 3.3 3.5 1.9 -1.8
Medication: Bendroflumethiazide 0.4 0.6 0.9 0.9 -0.5
Medication: Paracetamol 1.0 1.5 1.8 -1.3 1.1
Medication: Lisinopril 5.3 6.8 7.3 2.7 -2.5
Medication: Atorvastatin 0.0 0.0 0.0 -0.2 0.1
Illnesses of father: High blood pressure 0.0 0.1 0.1 0.3 0.1
Alcohol drinker status: Never 0.6 0.7 0.7 0.8 -0.8
Ever smoked 0.6 1.0 1.3 0.8 -1.1
Basal metabolic rate 0.5 3.0 4.8 -2.2 1.1
Leg fat percentage (left) 4.6 16.6 18.9 -3.8 4.3
Arm fat-free mass (left) 0.8 4.0 5.9 -2.4 1.5
Number of operations (self-reported) 0.1 0.1 0.2 -0.3 0.4
Average weekly beer plus cider intake 1.5 2.2 2.8 1.7 -1.3
Irritability 0.1 0.2 0.3 -0.6 0.4
Risk taking 0.0 0.0 0.0 0.0 -0.2
Ever had prostate specific antigen (PSA) test 2.4 2.8 3.5 -1.9 1.5
Fractured/broken bones in last 5 years 1.5 2.0 2.0 1.4 -1.4
Age started oral contraceptive pill 0.3 0.4 0.5 0.4 -0.7
Diastolic blood pressure, automated reading 3.0 9.3 9.3 3.0 -3.0
Ever depressed for a whole week 0.5 0.6 1.0 -1.0 -0.4
Unable to work because of sickness or disability 1.0 1.3 1.7 -1.3 1.0
Commuting to job workplace: Cycle 0.6 0.7 1.1 0.5 -1.0
Myopia 0.0 0.1 0.1 -0.3 -0.2
Vascular/heart problems diagnosed by doctor 4.0 10.9 11.5 -3.2 3.4
Cholesterol lowering medication 0.6 0.9 1.3 1.1 -0.7
Medication: Omeprazole (e.g. Zanprol) 0.7 0.8 0.9 0.9 -0.9
Pain experienced in last month 1.5 2.5 3.3 1.3 -1.8
Supplements: Calcium 0.0 0.0 0.0 0.2 0.1
Basal cell carcinoma (self-reported) 0.4 0.5 0.5 -0.6 0.7
Heart attack/myocardial infarction (self-reported) 0.6 0.8 0.9 -1.0 0.8
Deep venous thrombosis (DVT) (self-reported) 1.8 2.3 3.0 -1.7 1.2
Heart disease (siblings) 0.2 0.2 0.3 -0.6 0.4
Alcohol drinker status: Previous 0.1 0.2 0.3 0.3 0.5
Pack years of smoking 1.3 1.9 2.7 1.6 -1.1
Impedance of whole body 1.0 5.2 6.0 -2.5 2.1
Leg fat mass (left) 3.8 15.0 15.3 -3.8 3.9
Arm predicted mass (left) 0.7 3.4 5.1 -2.3 1.3