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chr3:54,846,329-59,191,320

Best TWAS P=2.3e-48 · Best GWAS P=3.4e-44 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	DNAH12	0.07	0.07	lasso	3	0.07	2.1e-09	-5.71	-6.2	5.6e-10	0.08	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	ERC2	0.12	0.00	bslmm	972	0.04	1.8e-05	-6.67	-7.8	5.4e-15	0.34	0.56	0.08	FALSE
3	CommonMind	Brain Pre-frontal Cortex	KCTD6	0.05	0.02	lasso	9	0.01	8.1e-03	7.35	7.6	2.1e-14	-0.06	0.40	0.02	FALSE
4	CommonMind	Brain Pre-frontal Cortex	PXK	0.12	0.00	bslmm	473	0.03	1.9e-04	7.90	5.6	1.8e-08	0.01	0.33	0.02	FALSE
5	CommonMind	Brain Pre-frontal Cortex	RPP14	0.08	0.05	lasso	4	0.08	1.3e-09	7.77	6.1	1.1e-09	-0.06	1.00	0.00	FALSE
6	GTEx	Adipose Subcutaneous	FAM208A	0.12	0.09	enet	11	0.12	1.1e-09	-7.78	11.1	1.7e-28	-0.86	0.02	0.98	FALSE
7	GTEx	Adipose Subcutaneous	CCDC66	0.23	0.07	lasso	2	0.12	7.0e-10	-6.18	5.3	1.1e-07	-0.58	0.98	0.02	FALSE
8	GTEx	Adipose Visceral Omentum	ABHD6	0.15	0.00	lasso	7	0.00	2.6e-01	-5.30	-5.5	4.5e-08	0.03	0.08	0.21	TRUE
9	GTEx	Adrenal Gland	RP11-755B10.4	0.11	0.06	lasso	11	0.04	1.4e-02	5.41	-5.4	7.1e-08	0.00	0.28	0.07	TRUE
10	GTEx	Artery Aorta	CCDC66	0.21	0.22	lasso	3	0.20	4.1e-11	-6.18	6.1	9.5e-10	-0.63	1.00	0.00	FALSE
11	GTEx	Artery Tibial	CCDC66	0.32	0.22	lasso	5	0.25	1.6e-19	-6.18	5.3	1.5e-07	-0.56	1.00	0.00	FALSE
12	GTEx	Artery Tibial	RP11-755B10.4	0.11	0.06	enet	13	0.04	2.1e-04	5.49	-6.0	2.4e-09	-0.05	0.55	0.03	TRUE
13	GTEx	Brain Caudate basal ganglia	CCDC66	0.18	0.16	lasso	5	0.16	3.3e-05	-6.18	5.6	2.0e-08	-0.58	0.26	0.19	FALSE
14	GTEx	Brain Cerebellar Hemisphere	PDHB	0.21	0.13	lasso	4	0.07	7.6e-03	7.88	8.0	1.5e-15	-0.05	0.22	0.05	TRUE
15	GTEx	Brain Cerebellum	PDHB	0.20	0.03	enet	20	0.10	5.8e-04	7.86	5.6	1.7e-08	-0.03	0.09	0.05	TRUE
16	GTEx	Brain Cortex	CCDC66	0.18	0.24	lasso	1	0.20	3.8e-06	-6.18	6.2	6.3e-10	-0.63	0.07	0.74	FALSE
17	GTEx	Brain Cortex	RP11-802O23.3	0.34	0.06	lasso	7	0.05	1.8e-02	7.82	7.7	1.4e-14	-0.05	0.10	0.05	FALSE
18	GTEx	Brain Frontal Cortex BA9	CCDC66	0.16	0.18	lasso	3	0.14	1.3e-04	-6.18	6.6	4.0e-11	-0.65	0.14	0.45	FALSE
19	GTEx	Brain Hippocampus	CCDC66	0.23	0.23	lasso	3	0.20	2.1e-05	-8.72	8.6	7.1e-18	-0.63	0.25	0.16	TRUE
20	GTEx	Brain Hypothalamus	CCDC66	0.18	0.26	lasso	3	0.22	5.6e-06	-6.18	5.8	7.3e-09	-0.63	0.13	0.25	FALSE
21	GTEx	Brain Putamen basal ganglia	CCDC66	0.36	0.28	lasso	3	0.25	1.3e-06	-6.18	5.8	6.6e-09	-0.59	0.13	0.31	FALSE
22	GTEx	Breast Mammary Tissue	CCDC66	0.19	0.21	lasso	3	0.19	5.7e-10	-6.18	6.0	1.6e-09	-0.64	0.47	0.53	FALSE
23	GTEx	Breast Mammary Tissue (Male)	CCDC66	0.05	0.03	lasso	3	0.04	5.1e-02	-8.77	7.3	3.2e-13	-0.61	0.04	0.13	FALSE
24	GTEx	Breast Mammary Tissue (Female)	CCDC66	0.16	0.06	enet	10	0.14	4.3e-05	-6.18	5.4	7.1e-08	-0.68	0.03	0.83	FALSE
25	GTEx	Cells EBV-transformed lymphocytes	CCDC66	0.45	0.27	enet	37	0.29	3.7e-10	-10.65	-9.3	1.3e-20	0.34	0.99	0.00	TRUE
26	GTEx	Cells Transformed fibroblasts	FAM208A	0.10	0.00	lasso	4	0.00	1.3e-01	-13.78	12.1	6.8e-34	-0.94	0.01	0.98	FALSE
27	GTEx	Cells Transformed fibroblasts	PXK	0.12	0.13	lasso	9	0.12	2.6e-09	-5.94	-6.0	1.7e-09	0.05	1.00	0.00	FALSE
28	GTEx	Cells Transformed fibroblasts	ARF4	0.18	0.17	lasso	9	0.16	9.1e-12	7.82	-8.1	4.0e-16	-0.01	1.00	0.00	FALSE
29	GTEx	Colon Transverse	ARF4	0.20	0.10	lasso	10	0.12	1.7e-06	7.82	-7.8	4.3e-15	-0.03	0.80	0.02	FALSE
30	GTEx	Esophagus Mucosa	ARHGEF3	0.12	0.06	enet	13	0.03	2.7e-03	-10.57	-7.4	1.9e-13	0.20	0.15	0.09	FALSE
31	GTEx	Esophagus Mucosa	CCDC66	0.23	0.14	lasso	3	0.17	2.9e-11	-6.18	5.8	5.1e-09	-0.64	0.96	0.03	FALSE
32	GTEx	Esophagus Muscularis	CCDC66	0.27	0.25	lasso	6	0.26	8.0e-16	-6.18	6.3	2.7e-10	-0.63	1.00	0.00	FALSE
33	GTEx	Heart Atrial Appendage	ACOX2	0.13	0.00	enet	11	0.02	5.9e-02	-4.61	6.2	5.4e-10	-0.06	0.14	0.04	FALSE
34	GTEx	Heart Left Ventricle	FLNB-AS1	0.11	0.00	lasso	4	0.00	2.0e-01	7.57	6.6	5.3e-11	0.00	0.07	0.20	FALSE
35	GTEx	Liver	PDE12	0.23	0.00	enet	20	0.03	6.6e-02	3.34	-7.0	2.0e-12	0.03	0.05	0.40	FALSE
36	GTEx	Lung	CCDC66	0.13	0.15	lasso	2	0.15	1.4e-11	-6.18	6.2	6.3e-10	-0.63	1.00	0.00	FALSE
37	GTEx	Nerve Tibial	CCDC66	0.30	0.27	lasso	4	0.27	2.1e-19	-6.18	6.9	5.9e-12	-0.66	1.00	0.00	FALSE
38	GTEx	Ovary	CCDC66	0.47	0.22	lasso	7	0.14	2.5e-04	-6.18	6.4	1.8e-10	-0.64	0.07	0.18	FALSE
39	GTEx	Ovary	RP11-755B10.4	0.24	0.21	lasso	8	0.19	2.4e-05	4.19	-5.4	6.0e-08	0.07	0.12	0.06	TRUE
40	GTEx	Pancreas	CCDC66	0.19	0.16	lasso	3	0.15	9.1e-07	-6.18	6.1	1.1e-09	-0.63	0.45	0.05	FALSE
41	GTEx	Pituitary	CCDC66	0.16	0.16	enet	31	0.12	6.8e-04	-6.18	10.8	2.3e-27	-0.78	0.02	0.94	FALSE
42	GTEx	Skin Sun Exposed Lower leg	FAM208A	0.06	0.04	lasso	2	0.03	2.0e-03	-8.95	8.9	4.4e-19	-0.61	0.23	0.41	TRUE
43	GTEx	Skin Sun Exposed Lower leg	CCDC66	0.09	0.09	lasso	5	0.05	8.1e-05	-6.18	5.9	3.8e-09	-0.61	0.94	0.00	FALSE
44	GTEx	Stomach	CCDC66	0.16	0.06	lasso	4	0.06	8.5e-04	-6.18	6.5	8.6e-11	-0.66	0.07	0.64	FALSE
45	GTEx	Thyroid	FLNB	0.10	0.08	lasso	8	0.08	1.1e-06	-2.48	5.4	5.2e-08	0.05	0.80	0.02	TRUE
46	GTEx	Thyroid	CCDC66	0.22	0.26	lasso	4	0.26	5.9e-20	-6.18	6.8	8.9e-12	-0.67	1.00	0.00	FALSE
47	GTEx	Thyroid	FLNB-AS1	0.10	0.08	lasso	3	0.05	1.5e-04	7.30	7.5	8.7e-14	0.03	0.87	0.00	FALSE
48	GTEx	Thyroid	RP11-802O23.3	0.06	0.05	lasso	4	0.04	9.9e-04	7.77	7.7	1.1e-14	-0.05	0.50	0.03	FALSE
49	GTEx	Whole Blood	PXK	0.06	0.06	lasso	1	0.06	2.3e-06	-5.51	5.5	3.6e-08	-0.04	0.92	0.00	FALSE
50	METSIM	Adipose	ACOX2	0.06	0.02	bslmm	419	0.02	1.3e-04	0.19	6.7	2.4e-11	0.02	0.33	0.10	FALSE
51	METSIM	Adipose	DNASE1L3	0.09	0.01	enet	14	0.06	4.1e-09	-4.97	6.0	2.1e-09	-0.01	0.99	0.00	FALSE
52	NTR	Blood	DNASE1L3	0.03	0.02	lasso	4	0.03	3.2e-09	-5.29	5.8	8.8e-09	-0.01	1.00	0.00	FALSE
53	NTR	Blood	PDHB	0.02	0.01	bslmm	434	0.01	1.1e-03	-6.09	-5.5	3.0e-08	0.00	0.74	0.01	FALSE
54	NTR	Blood	RPP14	0.01	0.01	lasso	1	0.01	2.2e-03	-5.22	-5.2	1.8e-07	0.01	0.82	0.00	FALSE
55	ROSMAP	Brain Pre-frontal Cortex	PDHB	0.21	0.24	lasso	4	0.30	1.1e-38	7.34	6.3	4.0e-10	-0.06	1.00	0.00	FALSE
56	ROSMAP	Brain Pre-frontal Cortex	ARF4	0.12	0.15	lasso	7	0.16	1.4e-19	7.86	9.2	3.3e-20	-0.02	1.00	0.00	TRUE
57	ROSMAP	Brain Pre-frontal Cortex	CCDC66	0.24	0.24	lasso	6	0.25	1.0e-31	-6.18	5.6	2.7e-08	-0.57	1.00	0.00	FALSE
58	YFS	Blood	ABHD6	0.02	0.02	lasso	4	0.02	8.4e-07	6.25	6.1	1.3e-09	-0.02	0.97	0.00	TRUE
59	YFS	Blood	CCDC66	0.11	0.09	lasso	8	0.11	6.0e-34	-10.46	-11.2	5.3e-29	0.50	1.00	0.00	FALSE
60	The Cancer Genome Atlas	Breast Invasive Carcinoma	CCDC66	0.09	0.03	lasso	8	0.05	4.2e-11	-9.38	-12.4	3.9e-35	0.65	0.19	0.81	FALSE
61	The Cancer Genome Atlas	Colon Adenocarcinoma	CCDC66	0.14	0.12	lasso	2	0.10	1.2e-06	-9.29	-9.2	2.4e-20	0.43	0.64	0.14	FALSE
62	The Cancer Genome Atlas	Glioblastoma Multiforme	CCDC66	0.19	0.02	enet	14	0.12	1.7e-04	2.41	-8.3	8.0e-17	0.24	0.04	0.07	TRUE
63	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CCDC66	0.05	0.05	blup	56	0.06	1.0e-07	-13.93	-14.4	4.4e-47	0.81	0.00	1.00	FALSE
64	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C3orf63	0.03	0.01	enet	4	0.01	1.3e-02	-13.77	12.7	1.0e-36	-0.93	0.01	0.82	FALSE
65	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CCDC66	0.09	0.05	blup	56	0.06	5.3e-07	-10.62	-11.9	1.1e-32	0.60	0.90	0.10	FALSE
66	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	ABHD6	0.09	0.07	lasso	3	0.03	4.3e-03	7.77	7.7	1.7e-14	-0.04	0.00	0.98	TRUE
67	The Cancer Genome Atlas	Brain Lower Grade Glioma	CCDC66	0.16	0.13	enet	12	0.16	3.1e-17	-10.46	-9.8	9.4e-23	0.29	1.00	0.00	FALSE
68	The Cancer Genome Atlas	Lung Adenocarcinoma	CCDC66	0.05	0.06	blup	56	0.05	9.7e-07	-13.91	-14.6	2.3e-48	0.80	0.00	1.00	TRUE
69	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	CCDC66	0.03	0.03	blup	56	0.03	9.6e-05	-9.29	-11.9	1.1e-32	0.57	0.34	0.26	FALSE
70	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	DNASE1L3	0.05	0.05	blup	58	0.06	2.5e-07	-5.92	7.2	4.5e-13	-0.01	0.98	0.01	FALSE
71	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	FAM116A	0.17	0.11	enet	3	0.10	6.7e-05	-5.63	-5.3	1.1e-07	-0.13	0.10	0.04	FALSE
72	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	CCDC66	0.08	0.01	blup	56	0.07	7.2e-04	-10.46	-9.8	1.0e-22	0.36	0.12	0.07	FALSE
73	The Cancer Genome Atlas	Prostate Adenocarcinoma	CCDC66	0.15	0.10	enet	11	0.13	7.3e-14	-9.29	-9.7	2.1e-22	0.39	1.00	0.00	TRUE
74	The Cancer Genome Atlas	Prostate Adenocarcinoma	RPP14	0.04	0.03	lasso	2	0.02	1.9e-03	6.98	-6.8	1.3e-11	0.04	0.10	0.44	FALSE
75	The Cancer Genome Atlas	Prostate Adenocarcinoma	WNT5A	0.06	0.05	enet	5	0.05	1.0e-05	10.95	11.7	1.7e-31	-0.04	0.12	0.87	TRUE
76	The Cancer Genome Atlas	Rectum Adenocarcinoma	CCDC66	0.20	-0.01	lasso	3	0.00	3.0e-01	-9.29	-9.1	7.1e-20	0.49	0.03	0.19	FALSE
77	The Cancer Genome Atlas	Stomach Adenocarcinoma	CCDC66	0.05	0.01	blup	57	0.02	8.4e-03	-9.38	-11.8	3.5e-32	0.64	0.06	0.58	FALSE
78	The Cancer Genome Atlas	Testicular Germ Cell Tumors	RPP14	0.10	0.06	lasso	8	0.08	1.2e-03	-5.22	-5.2	1.6e-07	0.03	0.03	0.22	FALSE
79	The Cancer Genome Atlas	Thyroid Carcinoma	CCDC66	0.14	0.05	blup	56	0.08	2.3e-08	-6.18	-6.8	1.2e-11	0.04	0.92	0.00	FALSE