TWAS hub - DNASE1L3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0863	0.0257	1.4e-07	0.015	0.052	0.058	0.052	0.052	2.3e-03	2.7e-08	4.1e-09	2.6e-08	2.7e-08
2	NTR	Blood	0.0276	0.0098	2.9e-05	0.021	0.013	0.027	0.018	0.027	1.5e-07	3.0e-05	3.9e-09	1.2e-06	3.2e-09
3	YFS	Blood	0.1282	0.0266	0.0e+00	0.088	0.095	0.112	0.107	0.112	2.2e-27	2.0e-29	1.3e-34	4.6e-33	9.2e-35
4	TCGA	Lung Squamous Cell Carcinoma	0.0537	0.0217	1.8e-06	0.048	0.060	0.057	NA	0.054	3.4e-06	2.5e-07	4.3e-07	NA	8.1e-07
5	TCGA	Prostate Adenocarcinoma	0.0429	0.0231	3.8e-03	0.011	0.011	0.020	NA	0.017	2.3e-02	2.3e-02	3.4e-03	NA	6.4e-03
6	TCGA	Thyroid Carcinoma	0.0520	0.0290	9.1e-04	0.019	0.035	0.032	NA	0.025	5.2e-03	2.2e-04	4.2e-04	NA	1.7e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Blood Platelet Count	7.5	87.3	207.4	-8.0	-10.0	-10.1	-14.4	-6.2	3.5
Ever used hormone-replacement therapy (HRT)	7.2	9.2	15.0	-3.1	-3.9	-3.6	-3.4	-2.6	-0.5
Supplements: Fish oil (including cod liver oil)	5.8	7.6	13.4	2.5	3.2	3.2	2.3	3.7	-0.3
Mineral and other dietary supplements	5.6	7.5	10.5	-2.8	-3.2	-3.2	-2.5	-3.2	-0.1
Worry (Nagel 2018)	4.1	8.6	14.9	-2.8	-3.9	-3.6	-3.2	-2.4	0.5
Average weekly red wine intake	3.5	5.2	8.8	1.8	2.7	3.0	2.7	1.9	-1.2
Qualifications: NVQ or HND or HNC or equivalent	3.2	3.9	6.7	-2.6	-2.2	-1.8	-1.7	-2.3	-0.9
Wears glasses or contact lenses	3.1	3.5	7.8	0.7	2.1	2.8	1.7	1.4	-2.0
Overall health rating	2.7	5.9	8.8	-1.8	-2.8	-3.0	-2.7	-2.8	0.6
Lupus	2.6	3.9	13.2	1.4	-0.6	-2.1	-0.4	-1.8	3.6
Qualifications: College or University degree	2.6	8.0	14.5	2.8	3.0	2.7	3.1	3.8	0.6
Alcohol intake frequency.	2.6	6.1	11.1	-1.5	-2.9	-3.3	-2.4	-2.7	1.1
Supplements: Glucosamine	2.5	3.2	6.7	1.8	2.1	1.9	1.1	2.6	0.1
Suffer from ‘nerves’	2.5	4.0	8.0	-2.1	-2.8	-2.5	-0.8	-2.1	0.1
Breast Cancer	2.3	5.5	8.6	1.9	2.9	2.9	2.4	2.5	-0.6
Had other major operations	2.3	2.8	4.7	1.5	2.1	1.9	2.2	1.0	-0.8
Guilty feelings	2.3	3.5	5.7	1.2	2.0	2.4	2.4	1.8	-0.8
Waist Hip Ratio (WHR)	2.2	9.9	34.7	2.2	-1.5	-4.0	-1.2	0.2	5.9
Neck or shoulder pain in last month	2.2	3.1	6.5	-1.5	-1.9	-2.1	-1.3	-2.6	0.3
Leg pain on walking	2.2	2.8	5.4	1.2	2.3	2.2	1.4	1.7	-0.4
Supplements: Zinc	2.1	2.2	3.8	1.3	1.9	1.9	1.1	1.8	-0.1
Medication: Levothyroxine sodium	2.1	3.6	7.3	-1.3	-1.8	-1.9	-2.4	-2.7	0.1
Hypothyroidism (self reported)	2.0	4.7	9.1	-0.5	-2.2	-3.0	-2.2	-2.1	2.1
Length of working week for main job	2.0	2.2	4.5	-0.3	-1.4	-2.1	-1.3	-1.1	1.9
Hypothyroidism/myxoedema (self-reported)	2.0	3.8	6.3	-0.5	-1.9	-2.5	-2.2	-2.4	1.5
Qualifications: CSEs or equivalent	1.9	2.5	6.0	-0.6	-1.8	-2.4	-1.4	-0.8	1.6
Worrier / anxious feelings	1.9	3.5	6.2	-2.3	-2.5	-1.9	-2.2	-0.8	-0.4
Commuting to job workplace: Walk	1.9	2.1	4.1	1.2	1.9	2.0	1.6	0.2	-0.7
Medication: Atorvastatin	1.9	2.3	3.9	-1.6	-2.0	-1.5	-1.4	-1.8	-0.2
Ever had prostate specific antigen (PSA) test	1.9	2.2	4.2	0.1	1.4	2.1	1.5	1.1	-1.9
Age started oral contraceptive pill	1.9	2.4	6.2	-1.7	-0.3	0.6	-0.9	-2.0	-2.5
Supplements: Calcium	1.9	2.1	3.8	1.9	1.9	1.5	1.0	1.4	0.6
Fluid intelligence score	1.8	3.7	5.7	2.4	2.0	1.2	2.2	1.8	1.7
Age at first live birth	1.6	2.8	5.7	2.4	1.3	0.4	1.6	1.3	2.2
Emphysema/chronic bronchitis	1.6	1.8	2.9	0.2	-1.0	-1.7	-1.3	-1.5	1.7
Average weekly champagne plus white wine intake	1.6	2.3	4.2	1.4	1.4	1.6	2.0	1.6	-0.1
Average weekly beer plus cider intake	1.6	2.3	7.3	1.9	0.7	-0.5	1.2	0.6	2.7
Primary Biliary Cirrhosis	1.5	2.2	5.7	2.2	0.7	-0.3	1.1	0.9	2.4
Impedance of leg (left)	1.5	7.4	27.4	3.3	1.0	-1.3	0.9	1.6	5.2
Pain all over the body in last month	1.5	1.6	2.6	-1.3	-1.6	-1.0	-1.5	-0.5	-1.2
Frequency of tiredness / lethargy in last 2 weeks	1.5	2.4	3.5	-1.7	-1.9	-1.6	-1.9	-1.4	0.1
Age at last live birth	1.5	2.2	4.5	1.5	1.3	1.0	1.4	2.1	1.3
Medication: Aspirin	1.5	1.9	5.2	-1.7	-0.9	0.0	-0.8	-1.4	-2.3
Illnesses of father: High blood pressure	1.5	1.8	5.0	-1.3	-1.2	-1.4	-2.2	-0.8	0.6
Medication: Omeprazole (e.g. Zanprol)	1.5	1.8	5.5	-1.4	-1.3	-0.9	-0.7	-2.3	-0.7
Heart disease (siblings)	1.5	1.9	4.3	-1.0	-1.5	-1.6	-2.1	-1.0	0.4
Neuroticism (Nagel 2018)	1.4	3.2	6.2	-2.5	-2.0	-1.2	-2.4	-1.0	-1.1
Mean Putamen Volume	1.4	1.6	4.6	-1.5	-0.8	-0.4	-0.3	-2.1	-1.4
Height	1.4	27.9	52.4	6.0	5.8	4.1	7.2	4.7	2.7
Impedance of leg (right)	1.4	7.0	27.7	3.0	0.4	-1.8	0.6	1.2	5.3
Hearing difficulty/problems with background noise	1.4	2.3	5.5	1.5	1.7	1.6	0.7	2.3	-0.1
Alcohol intake versus 10 years previously	1.4	2.1	2.8	-1.6	-1.7	-1.5	-1.6	-1.5	0.1
Father’s age at death	1.4	1.8	4.0	0.6	1.6	2.0	1.2	0.4	-1.6
Pulse rate	1.4	2.4	6.3	-1.4	-1.1	-0.7	-1.1	-2.5	-1.8
Qualifications: A levels/AS levels or equivalent	1.4	3.2	7.0	1.2	1.6	1.8	2.2	2.6	0.4
Gout (self-reported)	1.4	1.9	3.9	-0.0	1.4	2.0	1.5	0.5	-1.6
Smoking status: Current	1.4	2.1	5.0	-0.7	-1.5	-1.8	-2.2	-0.7	1.1
Unable to work because of sickness or disability	1.4	1.9	5.7	2.4	1.4	0.6	1.2	0.5	1.2
Medication for hormone replacement therapy	1.3	1.5	2.9	-0.2	-1.2	-1.7	-1.3	-0.5	1.6
Vitamin and mineral supplements	1.3	1.8	2.8	-1.6	-1.7	-1.5	-1.2	-1.2	-0.2
Diabetes (mother)	1.3	1.6	2.8	-1.3	-1.5	-1.4	-0.9	-1.7	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	1.3	3.0	7.3	-0.3	-2.0	-2.7	-1.5	-0.5	2.1
Multivitamins +/- minerals	1.3	1.6	2.6	1.1	1.4	1.6	1.5	0.6	-1.1
Sitting height	1.3	9.2	14.1	3.2	3.4	2.8	3.8	3.1	1.3
Medication: Aspirin	1.3	1.6	4.3	-1.5	-0.9	-0.1	-0.7	-1.4	-2.1
Pain experienced in last month	1.3	2.2	3.4	1.7	1.7	1.3	1.9	1.2	0.9
Rheumatoid Arthritis	1.2	1.6	6.2	-1.3	-0.9	-0.7	-2.5	-0.5	-0.1
Type 2 Diabetes (T2D) (2018)	1.2	2.2	5.4	2.3	1.1	0.1	1.3	0.8	2.1
Chronotype (morning person)	1.2	2.8	7.0	2.0	1.5	0.9	2.6	1.1	1.0
High blood pressure (mother)	1.2	1.7	3.7	-0.4	-1.6	-1.9	-0.8	0.5	1.7
Had menopause	1.2	1.6	2.5	-1.6	-1.2	-0.6	-1.1	-1.2	-1.6
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.8	6.2	0.1	-1.7	-2.5	-1.0	-0.7	2.5
Number of live births	1.2	1.7	6.2	-1.0	0.6	1.6	0.1	0.3	-2.5
Lung FVC	1.1	5.4	17.9	-2.6	-0.6	1.1	-2.0	-1.3	-4.2
Current tobacco smoking	1.1	1.9	3.9	-0.4	-1.4	-1.7	-2.0	-0.8	1.3
Nervous feelings	1.1	2.0	3.9	-1.4	-2.0	-1.7	-1.3	-1.0	0.4
Pulse wave reflection index	1.1	1.4	3.6	1.8	0.8	-0.0	0.8	0.5	1.9
Headache pain in last month	1.1	1.8	3.1	-1.8	-1.5	-0.9	-1.0	-1.6	-1.2
Number of full sisters	1.1	1.3	3.1	-1.8	-1.2	-0.7	-1.1	-0.8	-0.9
Miserableness	1.1	2.0	5.5	-2.3	-1.3	-0.4	-1.4	0.4	-1.5
Blood Red Count	1.0	10.0	22.3	3.7	-0.1	-2.5	2.4	-3.5	4.7
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	3.3	1.4	1.1	1.1	1.8	0.4	0.1
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	2.3	-0.8	-1.4	-1.5	-0.6	-1.4	0.5
Hayfever/allergic rhinitis (self-reported)	1.0	1.4	2.6	-0.2	-1.1	-1.5	-1.4	0.2	1.6
Time employed in main current job	1.0	1.1	2.6	-1.1	-0.7	-0.3	-1.6	-1.0	-1.1
Lung cancer (father)	1.0	1.2	2.2	0.7	1.0	1.2	1.5	1.1	-0.9
Standing height	1.0	10.3	20.7	3.6	3.5	2.3	4.5	2.5	2.1
Medication: Blood pressure	1.0	1.8	3.7	-1.6	-0.9	-0.2	-1.7	-0.9	-1.9
Mood swings	1.0	1.7	3.0	-1.5	-1.7	-1.5	-1.6	0.2	0.6
Ever depressed for a whole week	1.0	1.2	3.7	1.9	0.8	0.2	1.3	0.6	1.0
HbA1C	0.9	1.0	2.7	0.8	1.2	1.1	0.5	1.6	-0.2
Sensitivity / hurt feelings	0.9	1.6	3.7	0.1	1.2	1.8	0.5	1.9	-0.9
Severe depression (siblings)	0.9	1.0	2.8	-1.1	-1.1	-0.8	-0.1	-1.7	-0.5
Number of incorrect matches in round	0.9	1.5	3.7	-1.2	-0.7	0.0	-1.1	-1.4	-1.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.1	2.9	1.4	0.3	-0.4	1.3	0.0	1.7
Mean time to correctly identify matches	0.9	1.8	3.5	1.0	1.5	1.9	1.1	-0.1	-1.6
Heart disease (mother)	0.9	1.1	2.4	-1.0	-0.9	-0.4	-1.0	-1.6	-1.1
Commuting to job workplace: Car/motor vehicle	0.9	1.1	3.6	1.1	-0.2	-0.9	0.4	0.7	1.9
Ever had bowel cancer screening	0.9	1.0	1.9	-1.0	-1.4	-1.3	-1.0	-0.6	0.4
Cholesterol lowering medication	0.9	1.3	3.5	-1.4	-1.1	-0.6	-1.9	0.4	-0.9
Schizophrenia vs Biploar Disorder	0.8	1.1	3.3	0.1	1.6	1.8	0.3	0.5	-0.5
Verbal and Numeric Reasoning (VNR)	0.8	2.0	4.6	1.5	1.5	1.1	2.2	1.1	0.7
Fasting Glucose	0.8	0.9	2.7	1.1	0.6	0.6	1.6	0.8	0.4
HDL Cholesterol	0.8	1.3	3.3	-1.8	-0.7	0.0	-1.1	0.2	-1.6
Triglycerides	0.8	1.3	3.2	1.8	0.7	-0.0	1.2	0.7	1.4
Pack years adult smoking proportion	0.8	1.3	3.0	1.3	-0.3	-1.1	-1.1	-0.6	1.7
Alcohol usually taken with meals	0.8	1.3	2.2	1.1	1.4	1.5	0.9	1.1	-0.7
Allergy	0.8	1.9	4.9	-1.4	-1.5	-1.2	-0.9	-2.2	-0.4
Falls in the last year	0.8	1.1	1.8	1.0	1.4	1.2	0.7	1.3	-0.2
Depression (self-reported)	0.8	0.9	1.7	1.2	0.9	0.6	1.3	0.9	0.7
Mouth/teeth dental problems: Loose teeth	0.8	1.0	3.0	-0.7	-0.9	-1.0	-1.7	-0.4	0.4
Medication for pain relief, constipation, heartburn	0.8	1.4	5.1	0.9	-0.4	-1.3	0.5	-0.5	2.3
Comparative height size at age 10	0.8	4.7	9.6	3.0	2.0	0.9	3.1	0.7	2.1
Family relationship satisfaction	0.8	1.0	2.2	1.5	0.6	0.2	1.0	-1.3	0.7
Supplements: Vitamin C	0.8	0.9	1.6	1.3	1.1	0.9	1.0	0.6	0.6
Illnesses of father: Heart disease	0.8	1.1	2.4	1.2	0.1	-0.6	1.3	-0.7	1.5
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.6	6.5	0.6	-0.6	-1.5	0.3	0.3	2.5
Ever taken oral contraceptive pill	0.8	0.8	1.4	-0.8	-1.2	-1.0	-1.1	-0.8	0.3
Hearing aid user	0.8	0.9	3.3	1.3	0.2	-0.5	-0.2	-0.1	1.8
Number of operations (self-reported)	0.8	1.2	2.0	1.2	1.2	1.2	1.4	0.9	-0.3
Commuting to job workplace: Cycle	0.8	0.9	2.6	-1.6	-0.5	0.5	0.0	-0.4	-1.6
Depressed Affect (Nagel 2018)	0.7	1.4	3.6	-1.8	-1.0	-0.5	-1.9	0.2	-0.6
Prostate Cancer	0.7	1.0	2.4	-1.3	-1.1	-0.8	-1.6	0.0	0.1
Age at First Birth	0.7	1.0	2.9	1.1	0.6	-0.1	1.3	0.1	1.7
Neuroticism (2016)	0.7	1.1	3.3	-1.8	-0.9	-0.3	-0.5	-0.6	-1.3
Heel T-Score	0.7	5.8	8.2	-2.3	-2.5	-2.6	-2.9	-2.9	0.1
Smoking Status	0.7	1.7	4.0	-0.8	-1.4	-1.6	-2.0	-0.2	1.0
Cardiovascular Disease	0.7	2.4	6.5	-1.0	-1.7	-1.8	-2.5	-0.3	0.8
Lung FEV1/FVC ratio	0.7	3.6	7.2	-1.6	-2.6	-2.7	-1.7	-1.2	0.8
Neuroticism	0.7	1.7	3.7	-1.9	-1.6	-1.1	-1.6	-0.1	-0.5
Taking other prescription medications	0.7	1.1	2.0	-1.0	-1.2	-0.9	-1.1	-1.4	-0.4
Hayfever, allergic rhinitis or eczema	0.7	1.6	3.3	1.6	1.2	0.6	0.8	1.8	1.1
Stomach or abdominal pain in last month	0.7	0.8	1.6	-0.4	-0.6	-1.1	-1.3	-0.9	0.9
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	1.9	0.6	1.3	1.4	0.4	1.1	-0.4
Birth weight of first child	0.7	1.4	2.4	1.0	1.4	1.4	1.6	0.9	-0.0
Ever highly irritable/argumentative for 2 days	0.7	0.8	2.0	-1.0	-0.8	-0.5	-1.4	-1.0	-0.5
Loud music exposure frequency	0.7	0.7	1.4	1.2	0.9	0.5	0.2	0.9	1.0
Number of full brothers	0.7	0.9	2.9	1.2	0.2	-0.6	0.3	-0.9	1.7
Eye problems/disorders: None of the above	0.7	0.9	2.0	-1.4	-0.4	0.3	-0.6	0.9	-1.3
Angina (self-reported)	0.7	0.9	1.7	-0.8	-0.8	-0.3	-1.2	-1.3	-0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	2.4	-0.5	-0.8	-0.8	-1.6	-0.9	0.4
Chest pain or discomfort	0.7	1.0	1.9	-0.9	-1.0	-0.9	-1.4	-1.2	-0.1
Medication for cholesterol	0.7	1.1	2.0	1.4	1.3	1.0	1.3	0.4	0.5
Breast cancer (self-reported)	0.7	0.8	1.9	-0.6	-0.8	-0.6	-1.4	-1.2	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.4	3.1	-1.8	-1.1	-0.2	-1.1	-0.9	-1.5
High cholesterol (Self-reported)	0.7	1.2	2.3	-1.3	-1.2	-0.8	-1.5	1.0	-0.2
Alcohol drinker status: Never	0.7	0.8	1.4	0.9	1.2	0.9	0.6	1.2	0.5
Impedance of whole body	0.7	3.4	13.6	1.9	0.4	-1.2	0.5	1.2	3.7
Bipolar Disorder (2011)	0.6	0.5	1.4	-0.6	-1.2	-1.1	-0.3	-0.2	0.3
Chronic bronchitis/emphysema (father)	0.6	0.7	2.4	-0.8	-0.4	-0.2	-0.5	-1.6	-0.9
Hair/balding pattern: Pattern 2	0.6	0.8	2.3	0.4	0.2	-0.5	-1.5	-0.3	1.4
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.3	0.9	1.1	1.0	1.0	0.2	-0.0
Arm fat percentage (right)	0.6	2.3	6.2	-2.0	-0.7	0.4	-1.7	0.3	-2.5
Peak expiratory flow (PEF)	0.6	1.4	2.3	-1.2	-1.5	-1.5	-1.2	-1.1	0.2
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	2.3	-0.5	0.5	1.3	1.0	0.6	-1.5
Medication: Amlodipine	0.6	0.8	3.1	-0.5	0.4	1.0	0.3	0.4	-1.8
Number of children fathered	0.6	0.7	2.6	-0.3	0.2	0.4	-1.0	1.6	-0.2
Medication: Omeprazole	0.6	0.7	2.5	-0.8	-0.7	-0.5	-0.2	-1.6	-0.4
Medication: Seretide 50 evohaler	0.6	0.7	1.4	1.0	1.2	0.9	-0.1	0.8	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.3	-1.1	-0.7	-0.5	-0.8	-1.0	-0.6
Arm fat percentage (left)	0.6	2.3	6.8	-1.9	-0.4	0.7	-1.4	0.7	-2.6
Asthma (self-reported)	0.6	1.1	1.8	1.2	0.9	0.5	1.3	1.3	0.7
Osteoporosis (self-reported)	0.6	0.7	2.2	1.5	0.8	0.4	-0.2	0.7	1.0
Osteoarthritis (self-reported)	0.6	0.7	1.5	-0.6	-1.2	-1.2	-0.2	-0.9	-0.1
Medication: Gliclazide	0.6	0.7	1.2	1.1	0.0	-0.5	1.0	-1.1	0.8
Number of self-reported non-cancer illnesses	0.6	1.0	1.3	-1.1	-1.2	-0.8	-1.0	-1.0	-0.8
Ever smoked	0.6	1.0	2.4	1.3	0.5	-0.0	-0.2	1.5	1.3
Myopia	0.6	0.9	2.0	-0.4	1.0	1.4	0.6	0.2	-1.3
Irritable Bowel Disease (IBD)	0.5	1.1	1.9	0.2	0.7	1.2	1.4	1.2	-1.0
Ulcerative Colitis (UC)	0.5	0.9	2.9	-0.6	0.2	1.0	0.9	0.6	-1.7
Systolic blood pressure, automated reading	0.5	1.5	3.0	0.7	1.3	1.4	-1.0	1.7	-0.8
Angina	0.5	0.7	1.8	-0.7	-0.6	-0.2	-1.3	-1.0	-0.8
Diabetes (father)	0.5	0.6	1.5	0.2	-0.4	-0.9	-1.2	-0.5	1.0
Age when periods started (menarche)	0.5	1.2	3.1	-0.8	-1.2	-1.2	0.6	-1.8	-0.2
Medication: Atenolol	0.5	0.6	1.7	-0.3	-0.5	-0.8	-1.3	-0.7	0.5
Body mass index (BMI)	0.5	2.2	7.4	-1.8	-0.4	0.7	-1.3	0.3	-2.7
Qualifications: None of the above	0.5	1.0	2.1	-0.5	-1.1	-1.3	-1.4	-0.7	0.5
Neuroticism score	0.5	1.1	2.8	-1.7	-1.4	-0.8	-1.0	0.1	-0.4
Happiness	0.5	0.6	0.9	0.9	0.9	0.8	0.8	0.7	0.4
Asthma	0.5	1.0	1.8	0.8	1.0	0.9	1.3	1.3	-0.0
Medication: Lansoprazole	0.5	0.6	1.6	-0.7	0.1	0.7	-1.1	-0.4	-1.3
Illnesses of mother	0.5	0.6	1.2	0.4	0.9	1.0	1.1	-0.2	-0.3
Pulse wave Arterial Stiffness index	0.5	0.6	1.7	1.2	0.6	0.3	1.3	0.0	0.4
Glaucoma (self-reported)	0.5	0.6	1.6	0.7	0.7	0.6	1.3	-0.7	0.3
Birth weight	0.5	1.0	1.5	0.9	1.1	1.0	1.2	1.2	0.3
Pulse rate, automated reading	0.5	1.7	4.1	-1.4	-1.0	-0.7	-1.3	-2.0	-1.1
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.8	0.8	0.6	0.3	1.4	0.5	0.4
Friendships satisfaction	0.5	0.7	1.5	0.6	-0.2	-0.8	-1.2	-0.3	1.2
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	1.6	1.0	1.0	0.8	0.9	1.2	-0.1
Arm fat mass (left)	0.5	1.9	6.7	-1.4	0.3	1.3	-0.5	1.0	-2.6
Financial situation satisfaction	0.5	0.6	1.4	-0.1	0.5	1.0	1.2	0.1	-1.0
Bipolar Disorder (2018)	0.4	0.6	3.1	0.4	0.3	0.5	1.8	-0.1	-0.6
Crohns Disease (2017)	0.4	1.0	2.5	1.2	0.8	0.5	1.6	0.8	0.5
Reaction Time	0.4	0.8	1.7	0.7	1.1	1.3	0.8	-0.0	-1.0
Ovarian Cancer	0.4	0.6	1.1	0.2	0.6	1.1	0.1	1.0	-0.9
Coronary Artery Disease (CAD)	0.4	0.5	1.6	0.3	0.7	0.6	-0.5	1.2	-0.1
LDL Cholesterol	0.4	0.6	1.2	0.1	-0.8	-0.9	-0.5	0.8	1.1
Respiratory disease	0.4	0.9	2.3	0.1	0.6	0.8	1.5	1.2	-0.9
Average weekly spirits intake	0.4	0.5	1.7	0.6	0.3	0.1	-0.3	1.3	0.9
Ever had hysterectomy (womb removed)	0.4	0.5	1.7	0.5	0.3	-0.3	-0.8	0.3	1.3
Townsend deprivation index at recruitment	0.4	0.6	2.1	0.7	0.2	-0.0	1.0	-1.4	-0.1
Fed-up feelings	0.4	0.7	1.9	-0.9	-0.8	-0.8	-1.4	-0.4	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	2.2	0.6	0.4	0.2	1.5	-0.5	0.1
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.5	1.5	-1.2	-0.6	-0.1	-0.5	-0.3	-1.0
Trunk fat-free mass	0.4	2.5	5.2	1.0	1.8	2.0	2.3	1.0	-0.8
Hip circumference	0.4	1.5	3.1	-0.2	1.0	1.7	0.8	1.2	-1.7
Hair/balding pattern: Pattern 3	0.4	0.5	1.8	-0.5	0.0	0.6	0.7	-0.5	-1.4
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	1.6	-1.1	-0.2	0.4	0.0	-0.3	-1.3
Prospective memory result	0.4	0.5	0.8	0.6	0.8	0.9	0.1	0.8	-0.7
Arm fat mass (right)	0.4	1.8	6.4	-1.2	0.4	1.3	-0.5	1.0	-2.5
Trunk predicted mass	0.4	2.5	5.3	1.1	1.8	2.0	2.3	1.0	-0.7
Tense / ‘highly strung’	0.4	0.6	1.3	-0.3	-1.0	-1.1	-0.6	0.2	1.0
Hair/balding pattern: Pattern 4	0.4	1.0	4.0	0.1	0.5	0.8	0.7	2.0	-0.5
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	2.2	1.0	0.5	-0.2	0.8	0.3	1.5
High blood pressure (siblings)	0.4	0.6	1.8	-0.5	0.1	0.6	-0.4	1.4	-0.9
Arm fat-free mass (right)	0.4	2.0	4.2	0.8	1.5	1.8	2.0	1.1	-0.7
Exposure to tobacco smoke outside home	0.4	0.5	0.8	-0.9	-0.8	-0.6	-0.8	-0.3	-0.6
Shortness of breath walking on level ground	0.4	0.5	0.8	0.8	0.9	0.8	-0.1	0.7	-0.5
Arm predicted mass (right)	0.4	2.2	3.9	0.7	1.7	2.0	1.9	1.3	-0.9
Illnesses of siblings: Diabetes	0.4	0.5	1.3	1.1	0.5	0.1	0.5	-0.8	0.8
Leg fat-free mass (right)	0.4	2.0	5.7	-0.9	0.7	1.8	1.1	0.7	-2.4
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.9	0.1	-0.1	-0.4	0.4	0.3	1.4
Qualifications: nursing, teaching	0.4	0.7	2.4	0.5	0.6	0.8	1.5	0.7	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	2.2	0.7	0.3	0.2	0.0	1.5	0.5
Leg predicted mass (right)	0.4	2.1	5.7	-0.9	0.8	1.8	1.2	0.7	-2.4
Tinnitus: Yes, now most or all of the time	0.4	0.4	1.1	0.5	-0.7	-1.0	0.1	-0.3	0.8
Medication: Paracetamol	0.4	0.6	1.2	-0.9	-1.1	-0.9	-0.9	-0.3	-0.0
Irritability	0.4	0.7	2.0	-1.4	-0.7	-0.1	-0.7	0.1	-1.1
Diastolic blood pressure, automated reading	0.4	1.1	4.2	0.4	0.7	0.7	-1.2	2.0	-0.0
Pack years of smoking	0.4	0.6	1.1	1.0	-0.1	-0.6	-1.0	-0.6	0.9
Bipolar Disorder or Schizophrenia	0.3	0.7	3.4	0.2	-0.1	-0.2	1.8	-0.7	0.4
Major Depression (MDD)	0.3	0.4	1.7	-0.4	-0.4	-0.4	-0.1	-1.3	-0.2
Schizophrenia (2014)	0.3	0.6	1.8	-0.1	-0.2	-0.7	1.0	-0.7	1.3
Type 2 Diabetes (T2D) (2012)	0.3	0.4	1.2	0.2	0.1	-0.1	0.6	1.1	0.7
Blood Eosinophil Count	0.3	2.4	5.3	2.3	1.6	0.7	1.1	1.0	1.9
Number of treatments/medications taken	0.3	0.6	1.7	-0.5	-0.1	0.3	-1.3	0.7	-1.0
Hearing difficulty/problems: Yes	0.3	0.5	2.2	-0.5	0.2	0.7	-0.2	-0.3	-1.5
Relative age of first facial hair	0.3	0.6	1.4	-0.9	-0.8	-0.7	-1.2	-0.7	0.1
Medication: Metformin	0.3	0.4	1.0	0.9	0.8	0.5	1.0	-0.0	0.1
Leg fat-free mass (left)	0.3	1.6	4.6	-0.9	0.6	1.5	1.0	0.6	-2.1
Trunk fat percentage	0.3	1.1	3.0	-0.9	0.3	0.9	-0.3	1.3	-1.7
Hand grip strength (right)	0.3	0.9	3.2	0.7	0.7	0.2	0.3	1.1	1.8
Average weekly fortified wine intake	0.3	0.4	0.6	0.7	-0.3	-0.6	0.6	-0.8	0.7
Maternal smoking around birth	0.3	0.4	1.2	0.4	1.1	1.0	0.4	0.2	-0.3
Leg predicted mass (left)	0.3	1.6	4.8	-0.9	0.6	1.5	1.0	0.5	-2.2
Trunk fat mass	0.3	1.3	2.5	-0.4	0.9	1.4	0.3	1.6	-1.5
Past tobacco smoking	0.3	0.6	2.2	-0.7	-0.3	-0.1	0.2	-1.5	-0.7
Forced vital capacity (FVC)	0.3	1.1	2.6	0.0	1.2	1.6	0.3	1.4	-0.8
Diabetes (self-reported)	0.3	0.4	0.8	0.9	0.8	0.6	0.7	0.2	0.0
Weight	0.3	1.5	2.9	-0.0	1.2	1.7	0.7	1.4	-1.6
Impedance of arm (right)	0.3	1.4	5.6	0.5	-0.5	-1.5	-0.3	0.0	2.4
Noisy workplace	0.3	0.4	1.7	0.2	-0.2	-0.4	-1.3	0.6	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.6	0.7	0.1	-0.5	0.6	0.2	1.3
Blood clot in the leg (DVT)	0.3	0.4	0.9	0.8	0.2	-0.1	-0.6	0.9	0.5
Pulse wave peak to peak time	0.3	0.4	1.2	-1.1	-0.4	-0.1	-0.8	-0.0	-0.3
Whole body fat mass	0.3	1.2	2.9	-0.5	0.7	1.3	-0.1	1.4	-1.7
Whole body fat-free mass	0.3	1.8	3.3	0.1	1.3	1.8	1.7	0.8	-1.4
Loneliness, isolation	0.3	0.4	0.6	-0.6	-0.7	-0.7	-0.7	-0.6	0.3
Diabetes diagnosed by doctor	0.3	0.6	1.0	0.9	1.0	0.9	0.9	0.2	-0.3
Back pain experienced in last month	0.3	0.4	1.2	0.3	-0.2	-0.7	-1.1	-0.4	0.7
Whole body water mass	0.3	1.8	3.4	0.2	1.3	1.9	1.7	0.8	-1.5
Eye problems/disorders: Glaucoma	0.3	0.4	0.8	0.4	0.8	0.9	0.8	-0.3	-0.3
Medication: Bendroflumethiazide	0.3	0.5	1.1	-0.2	0.6	0.7	-1.1	0.9	-0.5
Medication: Lisinopril	0.3	0.4	1.5	0.3	-0.1	-0.1	-0.7	1.2	0.2
Basal metabolic rate	0.3	1.8	3.4	0.0	1.2	1.8	1.5	1.0	-1.6
Arm fat-free mass (left)	0.3	1.6	3.1	0.5	1.4	1.8	1.5	1.0	-1.1
Risk taking	0.3	0.4	1.0	1.0	0.1	-0.3	0.5	0.3	1.0
Deep venous thrombosis (DVT) (self-reported)	0.3	0.3	0.6	0.8	-0.0	-0.3	-0.6	0.8	0.5
Alcohol drinker status: Previous	0.3	0.3	0.9	0.8	-0.0	-0.5	0.4	-0.1	0.9
Intelligence (Savage-Jansen 2018)	0.2	0.5	1.7	-0.0	0.5	0.7	1.3	0.1	-0.7
Schizophrenia (2018)	0.2	0.5	0.9	-0.1	-0.3	-0.7	0.9	-0.7	0.9
Alzheimer’s Disease (in mother)	0.2	0.2	0.5	0.7	0.4	-0.0	0.2	0.1	0.7
Alzheimer’s Disease (including proxy)	0.2	0.3	0.9	0.6	0.3	-0.2	0.7	0.0	1.0
Crohns Disease (2012)	0.2	0.3	0.6	0.6	-0.4	-0.8	0.5	-0.3	0.7
BMI	0.2	1.4	3.8	-1.1	0.1	1.0	-1.0	1.2	-1.9
Systolic Blood Pressure	0.2	0.8	2.3	0.7	0.4	0.1	-1.5	1.2	0.5
Allergy or Eczema	0.2	0.6	2.9	0.7	0.5	0.2	-0.2	1.7	0.2
Hand grip strength (left)	0.2	0.6	2.9	0.7	0.6	0.0	0.3	0.1	1.7
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.8	0.7	0.4	0.2	0.9	-0.3	0.2
Relative age voice broke	0.2	0.3	1.1	-0.1	-0.0	-0.0	-1.1	0.5	0.6
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.7	0.2	-0.1	-0.4	0.2	-0.9	0.7
Heart attack	0.2	0.3	1.5	-0.0	0.1	-0.0	-1.2	0.3	0.4
Medication: Ramipril	0.2	0.3	1.0	-0.5	-0.4	-0.4	-0.0	-1.0	-0.3
Medication: Simvastatin	0.2	0.4	1.3	-0.2	-0.2	0.0	-1.1	0.9	-0.3
Impedance of arm (left)	0.2	1.0	4.0	0.6	-0.1	-0.9	0.3	0.7	2.0
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.7	-0.5	-0.3	-0.3	-0.8	-0.1	0.4
Forced vital capacity (FVC), Best measure	0.2	0.8	2.1	-0.1	1.0	1.5	0.5	0.8	-0.7
Body fat percentage	0.2	0.9	2.2	-0.8	0.2	0.8	-0.7	1.3	-1.5
Comparative body size at age 10	0.2	0.4	0.7	-0.5	0.4	0.8	-0.9	0.5	-0.8
Health satisfaction	0.2	0.3	0.8	0.1	0.8	0.9	-0.0	0.4	-0.5
Hypertension (Self-reported)	0.2	0.7	2.0	-0.9	-0.6	-0.1	-1.4	0.2	-1.0
Smoking status: Previous	0.2	0.3	0.9	0.4	0.4	0.4	0.5	1.0	-0.1
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.5	-0.7	-0.5	-0.6	-0.5	-0.7	-0.1
Eye problems/disorders: Cataract	0.2	0.3	0.6	0.8	0.1	-0.2	0.1	0.7	0.7
Illnesses of father: None of the above (group 1)	0.2	0.3	1.4	-0.4	-0.2	0.3	-0.3	0.1	-1.2
Mother’s age at death	0.2	0.2	0.7	-0.2	-0.1	0.3	0.8	-0.0	-0.8
Fractured/broken bones in last 5 years	0.2	0.2	0.8	0.9	0.2	0.0	-0.2	-0.4	0.3
Vascular/heart problems diagnosed by doctor	0.2	0.5	1.3	0.6	0.2	-0.2	1.1	-0.2	1.1
Heart attack/myocardial infarction (self-reported)	0.2	0.3	1.4	0.1	-0.0	-0.1	-1.2	0.1	0.5
Leg fat mass (left)	0.2	0.7	2.0	-0.1	0.6	0.9	-0.4	1.4	-0.8
Arm predicted mass (left)	0.2	1.1	2.2	0.2	1.1	1.5	1.2	0.8	-1.1
Depression (Nagel 2018)	0.1	0.2	0.5	0.3	0.1	-0.1	0.7	-0.7	0.3
Alzheimer’s Disease (in father)	0.1	0.1	0.4	0.0	0.3	0.1	0.7	-0.2	0.6
Body Mass Index (BMI) (2010)	0.1	0.2	0.6	-0.1	0.1	0.3	-0.4	0.8	-0.3
Ulcerative Colitis	0.1	0.1	0.4	0.1	-0.0	0.2	0.6	0.3	-0.1
Blood White Count	0.1	1.1	4.0	1.0	-0.5	-1.1	-0.0	0.2	2.0
Eye problems/disorders: Diabetes related eye disease	0.1	0.2	0.5	-0.5	-0.2	0.1	-0.0	-0.4	-0.7
Medication: Co-codamol	0.1	0.1	0.3	0.0	0.1	0.1	-0.1	-0.2	-0.6
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.5	0.0	0.3	0.3	0.7	0.3	-0.1
Serious illness, injury or assault to yourself	0.1	0.1	0.6	-0.3	-0.3	-0.1	-0.4	-0.8	-0.0
High blood pressure	0.1	0.3	0.8	-0.3	-0.0	0.3	-0.7	0.3	-0.9
Waist circumference	0.1	0.4	1.2	0.8	0.5	0.1	-0.6	1.1	0.4
Mouth/teeth dental problems	0.1	0.1	0.4	-0.1	-0.0	-0.0	0.6	-0.6	0.2
Illnesses of siblings	0.1	0.1	0.5	0.1	-0.2	-0.4	-0.1	-0.4	0.7
Medication: Cholesterol lowering	0.1	0.1	0.2	-0.3	-0.4	-0.1	-0.5	0.3	-0.1
Exposure to tobacco smoke at home	0.1	0.1	0.4	0.3	0.2	-0.1	0.7	-0.5	0.2
Breastfed as a baby	0.1	0.1	0.4	-0.4	0.0	0.1	0.6	-0.2	-0.2
Medication: Paracetamol	0.1	0.2	0.5	-0.7	-0.5	-0.2	-0.3	0.2	-0.3
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.4	-0.7	-0.3	-0.1	-0.3	0.2	-0.3
Leg fat percentage (right)	0.1	0.5	1.7	-0.1	-0.0	-0.0	-1.3	1.1	-0.1
Worry too long after embarrassment	0.1	0.1	0.3	-0.5	-0.5	-0.1	0.2	0.2	-0.3
Wheeze or whistling in the chest in last year	0.1	0.1	0.3	0.1	0.0	-0.3	-0.2	0.5	0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.3	-0.5	-0.3	-0.1	-0.2	0.2	-0.5
Migraine (self-reported)	0.1	0.1	0.4	-0.5	-0.1	0.0	0.3	0.3	-0.6
Medication: Ibuprofen	0.1	0.1	0.2	0.4	0.4	0.3	-0.2	0.4	-0.1
Medication: Allopurinol	0.1	0.1	0.2	-0.3	0.1	0.1	0.5	-0.3	-0.3
Leg fat mass (right)	0.1	0.6	1.7	-0.2	0.5	0.7	-0.5	1.3	-0.7
Had major operations	0.1	0.2	0.6	-0.5	-0.1	0.3	0.2	-0.0	-0.8
Knee pain experienced in last month	0.1	0.1	0.2	-0.4	-0.5	-0.3	0.1	0.2	-0.5
Long-standing illness, disability or infirmity	0.1	0.1	0.2	0.5	0.3	0.4	0.0	0.3	-0.0
Commuting to job workplace: Public transport	0.1	0.1	0.4	0.1	0.1	0.3	0.4	-0.7	-0.4
Medication: Blood pressure	0.1	0.2	0.4	-0.6	-0.6	-0.3	-0.1	0.2	-0.6
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.4	-0.1	0.1	0.1	-0.6	0.6	-0.1
Leg fat percentage (left)	0.1	0.4	1.5	-0.3	-0.0	0.1	-1.2	1.0	-0.3
Basal cell carcinoma (self-reported)	0.1	0.2	0.4	-0.6	-0.4	0.1	-0.3	-0.2	-0.5
Hair Pigment	0.0	1.4	4.0	1.5	1.2	0.3	0.5	-0.2	2.0
Tanning	0.0	0.6	1.0	-1.0	-0.9	-0.6	-0.8	-0.6	-0.6
Financial difficulties in last 2 years	0.0	0.1	0.2	-0.4	-0.3	-0.2	-0.1	0.1	0.2
Forced expiratory volume in 1-second (FEV1)	0.0	0.2	0.5	-0.1	0.4	0.5	0.0	0.7	0.1
Mouth/teeth dental problems: Dentures	0.0	0.1	0.3	0.2	-0.0	0.1	0.2	0.1	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.0	0.1	0.3	-0.0	0.5	0.5	0.1	0.4	0.1
Chronic bronchitis/emphysema (mother)	0.0	0.0	0.2	-0.4	-0.1	0.1	0.1	0.3	0.0

Hub : Genes

DNASE1L3

Models

Trait associations