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chr3:155,070,465-159,243,593

Best TWAS P=5.31e-29 · Best GWAS P=1.43e-43 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	PTX3	0.06	0.08	enet	15	0.08	2.5e-10	4.5	-6.7	2.1e-11	-0.06	0.98	0.02	FALSE
2	GTEx	Adipose Subcutaneous	RP11-538P18.2	0.15	0.15	lasso	7	0.18	9.4e-15	-4.7	7.9	3.0e-15	0.60	0.97	0.03	FALSE
3	GTEx	Adipose Subcutaneous	RP11-379F4.7	0.25	0.00	enet	18	0.05	3.6e-05	-5.7	-6.8	7.1e-12	-0.36	0.41	0.04	FALSE
4	GTEx	Adipose Visceral Omentum	RSRC1	0.16	0.08	enet	12	0.09	2.5e-05	-12.6	9.3	1.3e-20	0.66	0.62	0.34	FALSE
5	GTEx	Adipose Visceral Omentum	RP11-379F4.4	0.09	0.06	lasso	3	0.08	5.0e-05	-5.2	6.1	1.1e-09	0.32	0.40	0.03	FALSE
6	GTEx	Adipose Visceral Omentum	RP11-538P18.2	0.23	0.10	enet	22	0.16	1.2e-08	-12.5	8.0	1.3e-15	0.57	0.85	0.15	FALSE
7	GTEx	Artery Aorta	KCNAB1	0.15	0.14	lasso	6	0.14	7.4e-08	-4.3	5.7	1.2e-08	0.01	0.91	0.00	FALSE
8	GTEx	Artery Aorta	RSRC1	0.09	0.04	lasso	5	0.03	1.4e-02	-9.6	10.0	2.1e-23	0.60	0.43	0.11	FALSE
9	GTEx	Artery Aorta	RP11-538P18.2	0.11	0.09	lasso	3	0.08	2.9e-05	-4.9	7.1	9.8e-13	0.57	0.86	0.08	TRUE
10	GTEx	Artery Coronary	RP11-538P18.2	0.11	0.16	lasso	4	0.10	3.2e-04	-9.7	9.6	5.5e-22	0.71	0.38	0.46	FALSE
11	GTEx	Artery Tibial	TIPARP	0.13	0.02	enet	17	0.05	8.2e-05	1.8	5.8	4.8e-09	0.06	0.44	0.22	FALSE
12	GTEx	Artery Tibial	KCNAB1	0.14	0.04	enet	14	0.07	7.5e-06	4.8	5.7	1.4e-08	0.03	0.91	0.00	FALSE
13	GTEx	Artery Tibial	RSRC1	0.13	0.13	lasso	6	0.11	3.5e-09	-4.7	5.9	4.4e-09	0.48	0.99	0.01	FALSE
14	GTEx	Artery Tibial	RP11-379F4.4	0.12	0.06	lasso	3	0.08	5.5e-07	-5.2	6.4	1.6e-10	0.31	0.98	0.00	FALSE
15	GTEx	Artery Tibial	RP11-538P18.2	0.17	0.14	enet	24	0.21	3.7e-16	-4.7	7.7	1.3e-14	0.64	1.00	0.00	FALSE
16	GTEx	Brain Cerebellar Hemisphere	RP11-538P18.2	0.17	0.11	lasso	4	0.04	4.1e-02	-9.8	9.4	6.7e-21	0.67	0.10	0.18	FALSE
17	GTEx	Brain Cerebellum	RP11-538P18.2	0.19	0.06	enet	18	0.10	8.0e-04	7.1	9.3	2.0e-20	0.72	0.17	0.53	FALSE
18	GTEx	Brain Cortex	RSRC1	0.43	0.02	lasso	7	0.00	2.3e-01	-8.9	8.0	1.9e-15	0.52	0.07	0.16	FALSE
19	GTEx	Breast Mammary Tissue	RSRC1	0.14	0.10	lasso	6	0.13	4.9e-07	-4.7	6.3	2.9e-10	0.43	0.88	0.10	FALSE
20	GTEx	Breast Mammary Tissue	RP11-538P18.2	0.17	0.14	lasso	6	0.16	1.2e-08	-4.7	5.2	1.9e-07	0.48	1.00	0.00	FALSE
21	GTEx	Breast Mammary Tissue	RP11-379F4.7	0.10	0.02	lasso	10	0.02	2.9e-02	-6.1	-6.6	3.5e-11	-0.38	0.36	0.05	FALSE
22	GTEx	Breast Mammary Tissue (Male)	RSRC1	0.24	0.10	lasso	5	0.19	3.4e-05	-4.7	5.9	4.1e-09	0.44	0.09	0.11	FALSE
23	GTEx	Breast Mammary Tissue (Male)	LINC00886	0.17	0.03	enet	4	0.04	4.4e-02	-4.9	-5.4	8.0e-08	0.01	0.07	0.05	FALSE
24	GTEx	Breast Mammary Tissue (Female)	RSRC1	0.24	0.05	enet	43	0.13	1.4e-04	-4.9	8.4	5.6e-17	0.50	0.18	0.48	FALSE
25	GTEx	Breast Mammary Tissue (Female)	RP11-538P18.2	0.20	0.14	enet	13	0.17	9.4e-06	-5.5	5.7	9.5e-09	0.55	0.60	0.16	FALSE
26	GTEx	Breast Mammary Tissue (Female)	RP11-379F4.7	0.12	0.00	lasso	3	0.01	2.1e-01	-6.6	-6.6	4.5e-11	-0.34	0.08	0.25	TRUE
27	GTEx	Cells Transformed fibroblasts	RP11-538P18.2	0.10	0.08	enet	10	0.13	5.1e-10	-4.7	8.2	1.6e-16	0.63	0.99	0.01	FALSE
28	GTEx	Colon Sigmoid	RP11-538P18.2	0.11	0.05	lasso	8	0.08	7.6e-04	4.1	5.3	1.1e-07	0.42	0.10	0.31	FALSE
29	GTEx	Colon Transverse	SSR3	0.11	0.00	enet	22	0.01	9.2e-02	-4.7	5.5	2.9e-08	0.12	0.06	0.06	FALSE
30	GTEx	Esophagus Gastroesophageal Junction	RP11-538P18.2	0.21	0.12	lasso	4	0.12	3.5e-05	-8.2	11.0	2.2e-28	0.74	0.20	0.67	FALSE
31	GTEx	Esophagus Mucosa	RSRC1	0.09	0.02	enet	20	0.04	9.3e-04	-12.6	8.0	1.9e-15	0.42	0.17	0.57	FALSE
32	GTEx	Esophagus Mucosa	MLF1	0.22	0.30	lasso	5	0.28	2.6e-19	7.1	7.0	2.3e-12	0.56	1.00	0.00	FALSE
33	GTEx	Esophagus Mucosa	RP11-538P18.2	0.12	0.10	lasso	5	0.14	1.9e-09	-4.7	6.1	1.1e-09	0.48	0.48	0.51	FALSE
34	GTEx	Esophagus Muscularis	RSRC1	0.06	0.09	lasso	3	0.10	1.7e-06	-9.7	-9.7	4.4e-22	-0.70	0.41	0.44	FALSE
35	GTEx	Esophagus Muscularis	RP11-379F4.4	0.17	0.09	enet	8	0.10	1.2e-06	-6.9	7.4	1.6e-13	0.32	0.93	0.00	FALSE
36	GTEx	Esophagus Muscularis	RP11-538P18.2	0.11	0.16	lasso	5	0.15	1.2e-09	-9.7	-8.7	2.8e-18	-0.67	0.91	0.08	FALSE
37	GTEx	Heart Atrial Appendage	MLF1	0.19	0.14	enet	17	0.12	7.5e-06	4.7	-6.5	8.2e-11	-0.41	0.98	0.00	FALSE
38	GTEx	Heart Atrial Appendage	RP11-379F4.7	0.07	0.09	enet	11	0.01	1.4e-01	-9.6	-9.8	1.4e-22	-0.69	0.25	0.25	FALSE
39	GTEx	Heart Left Ventricle	MLF1	0.26	0.24	lasso	9	0.28	2.5e-15	4.8	-5.2	1.8e-07	-0.35	1.00	0.00	FALSE
40	GTEx	Heart Left Ventricle	LINC00886	0.25	0.08	lasso	10	0.07	1.5e-04	-5.1	-5.4	6.1e-08	0.02	0.47	0.06	FALSE
41	GTEx	Lung	RSRC1	0.09	0.05	enet	12	0.06	3.5e-05	-5.3	5.9	3.9e-09	0.43	0.89	0.01	TRUE
42	GTEx	Lung	RP11-379F4.4	0.10	0.06	lasso	3	0.06	1.7e-05	-5.3	5.6	2.0e-08	0.27	0.79	0.01	FALSE
43	GTEx	Lung	RP11-538P18.2	0.16	0.11	enet	17	0.17	6.6e-13	-5.4	7.0	1.8e-12	0.62	1.00	0.00	FALSE
44	GTEx	Lung	RP11-379F4.7	0.05	0.01	lasso	3	0.01	1.2e-01	-12.6	-9.8	7.0e-23	-0.65	0.16	0.09	FALSE
45	GTEx	Muscle Skeletal	RP11-538P18.2	0.09	0.08	lasso	2	0.05	1.3e-05	-4.7	5.9	3.0e-09	0.49	0.96	0.03	FALSE
46	GTEx	Nerve Tibial	RSRC1	0.10	0.15	lasso	3	0.12	9.9e-09	-4.7	5.3	9.4e-08	0.45	0.97	0.03	FALSE
47	GTEx	Nerve Tibial	RP11-538P18.2	0.21	0.18	enet	16	0.20	2.1e-14	-4.7	6.9	3.9e-12	0.60	1.00	0.00	FALSE
48	GTEx	Ovary	RP11-538P18.2	0.23	0.08	lasso	6	0.13	4.5e-04	-4.7	10.4	2.4e-25	0.77	0.05	0.45	FALSE
49	GTEx	Pancreas	RP11-538P18.2	0.14	0.02	lasso	11	0.02	5.3e-02	-9.7	9.8	1.1e-22	0.73	0.12	0.52	FALSE
50	GTEx	Skin Not Sun Exposed Suprapubic	RARRES1	0.15	0.09	lasso	4	0.15	1.9e-08	-6.9	6.2	6.4e-10	0.25	0.72	0.02	FALSE
51	GTEx	Skin Not Sun Exposed Suprapubic	RP11-538P18.2	0.09	0.10	enet	13	0.12	6.8e-07	-5.5	9.7	2.1e-22	0.72	0.62	0.38	FALSE
52	GTEx	Skin Sun Exposed Lower leg	RSRC1	0.09	0.09	lasso	2	0.08	4.4e-07	-4.7	5.2	2.2e-07	0.46	0.94	0.02	TRUE
53	GTEx	Skin Sun Exposed Lower leg	RP11-379F4.4	0.18	0.11	lasso	9	0.14	6.7e-12	-5.3	5.3	9.7e-08	0.22	1.00	0.00	FALSE
54	GTEx	Skin Sun Exposed Lower leg	RP11-538P18.2	0.13	0.12	enet	11	0.14	7.8e-12	-4.7	8.3	9.2e-17	0.64	1.00	0.00	FALSE
55	GTEx	Stomach	RSRC1	0.08	0.06	lasso	3	0.07	2.9e-04	-10.5	9.6	8.0e-22	0.74	0.44	0.44	TRUE
56	GTEx	Testis	MFSD1	0.14	0.11	enet	9	0.12	4.5e-06	-5.3	5.8	5.5e-09	0.30	0.77	0.02	FALSE
57	GTEx	Thyroid	RSRC1	0.07	0.04	lasso	7	0.02	8.5e-03	-12.6	11.2	5.3e-29	0.77	0.42	0.47	TRUE
58	GTEx	Thyroid	RP11-379F4.4	0.15	0.07	lasso	3	0.08	1.9e-06	-6.9	6.0	1.5e-09	0.27	0.97	0.00	FALSE
59	GTEx	Thyroid	RP11-538P18.2	0.14	0.13	lasso	5	0.12	1.2e-09	-4.7	8.9	6.3e-19	0.64	0.19	0.81	FALSE
60	GTEx	Uterus	LINC00886	0.30	0.13	lasso	5	0.14	1.1e-03	-4.9	-5.2	2.3e-07	-0.02	0.09	0.06	FALSE
61	GTEx	Vagina	RP11-538P18.2	0.25	0.19	lasso	3	0.18	6.7e-05	-9.9	9.6	8.9e-22	0.67	0.13	0.13	FALSE
62	METSIM	Adipose	CCNL1	0.03	0.01	blup	432	0.02	9.6e-04	-8.6	-8.2	1.6e-16	0.03	0.07	0.92	FALSE
63	METSIM	Adipose	MLF1	0.09	0.00	blup	399	0.04	1.1e-06	-9.4	-5.9	4.5e-09	-0.20	0.54	0.02	FALSE
64	METSIM	Adipose	VEPH1	0.05	0.02	blup	510	0.02	3.9e-04	3.6	-9.5	1.9e-21	-0.15	0.71	0.12	TRUE
65	YFS	Blood	CCNL1	0.09	0.16	bslmm	434	0.17	3.0e-52	-11.1	-10.7	9.1e-27	-0.02	0.02	0.98	TRUE
66	YFS	Blood	MLF1	0.03	0.01	enet	53	0.02	4.3e-06	-2.3	6.2	7.8e-10	0.31	0.44	0.07	FALSE
67	YFS	Blood	RSRC1	0.13	0.13	enet	26	0.17	8.8e-54	-5.5	5.5	4.1e-08	0.52	1.00	0.00	FALSE
68	The Cancer Genome Atlas	Breast Invasive Carcinoma	RSRC1	0.04	0.03	enet	11	0.04	4.5e-09	-8.9	7.8	4.7e-15	0.63	0.83	0.17	FALSE
69	The Cancer Genome Atlas	Colon Adenocarcinoma	MLF1	0.06	0.04	blup	45	0.04	2.0e-03	10.7	9.8	1.1e-22	0.75	0.00	0.88	FALSE
70	The Cancer Genome Atlas	Colon Adenocarcinoma	RARRES1	0.22	0.09	lasso	2	0.07	8.5e-05	-6.9	-6.9	5.6e-12	-0.28	0.00	1.00	FALSE
71	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SHOX2	0.09	0.01	enet	8	0.03	3.5e-04	12.4	-9.9	2.6e-23	-0.42	0.00	0.98	TRUE
72	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	LOC100287227	0.09	0.02	enet	8	0.02	1.3e-03	3.3	7.2	5.9e-13	0.02	0.01	0.53	TRUE
73	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	RARRES1	0.09	0.06	lasso	2	0.05	1.1e-06	-6.9	-6.9	5.6e-12	-0.28	0.00	1.00	FALSE
74	The Cancer Genome Atlas	Brain Lower Grade Glioma	RSRC1	0.05	0.03	blup	154	0.01	7.9e-03	-8.2	9.7	4.5e-22	0.65	0.21	0.20	FALSE
75	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	KCNAB1	0.04	0.00	blup	215	0.01	9.6e-03	-4.7	-6.3	3.2e-10	-0.03	0.06	0.12	TRUE
76	The Cancer Genome Atlas	Prostate Adenocarcinoma	RARRES1	0.05	0.02	blup	61	0.02	2.4e-03	-6.2	-6.4	1.8e-10	-0.34	0.11	0.62	TRUE
77	The Cancer Genome Atlas	Stomach Adenocarcinoma	LOC100287227	0.07	0.01	blup	47	0.02	9.8e-03	-6.1	6.7	2.6e-11	0.02	0.02	0.23	FALSE
78	The Cancer Genome Atlas	Testicular Germ Cell Tumors	GFM1	0.28	0.16	lasso	7	0.14	1.5e-05	7.0	6.7	1.9e-11	0.52	0.00	0.99	FALSE
79	The Cancer Genome Atlas	Testicular Germ Cell Tumors	LEKR1	0.12	0.03	blup	114	0.03	2.5e-02	-4.6	5.7	1.5e-08	0.03	0.02	0.54	FALSE
80	The Cancer Genome Atlas	Thyroid Carcinoma	CCNL1	0.06	0.02	lasso	3	0.04	6.9e-05	-9.4	7.2	6.5e-13	0.07	0.07	0.85	FALSE
81	The Cancer Genome Atlas	Thyroid Carcinoma	RARRES1	0.04	0.03	blup	61	0.02	1.8e-03	-6.1	-6.8	7.6e-12	-0.38	0.06	0.23	FALSE