Hub : Genes

CCNL1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0326	0.0135	3.6e-04	0.014	0.018	0.009	0.017	0.010	2.9e-03	9.6e-04	1.2e-02	9.9e-04	9.7e-03
2	YFS	Blood	0.0949	0.0186	0.0e+00	0.162	0.152	0.165	0.167	0.162	1.8e-50	3.3e-47	1.2e-51	3.0e-52	1.1e-50
3	TCGA	Thyroid Carcinoma	0.0610	0.0270	2.1e-05	0.019	0.040	0.026	NA	0.041	4.9e-03	8.0e-05	1.2e-03	NA	6.9e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.8	1.2	2.2	1.0	1.5	-0.7
Bipolar Disorder or Schizophrenia	0.1	0.3	0.8	-0.1	0.4	0.9
Depressed Affect (Nagel 2018)	0.1	0.2	0.4	0.6	0.4	0.4
Depression (Nagel 2018)	1.7	2.5	4.1	2.0	1.5	-1.1
Intelligence (Savage-Jansen 2018)	0.5	1.7	4.0	1.0	0.2	-2.0
Neuroticism (Nagel 2018)	0.3	0.6	1.2	0.6	1.1	0.5
Schizophrenia (2018)	0.7	1.4	2.8	-0.9	-0.7	1.7
Schizophrenia vs Biploar Disorder	0.2	0.2	0.5	-0.0	0.4	-0.7
Worry (Nagel 2018)	0.2	0.4	0.9	-0.5	0.1	0.9
Alzheimer’s Disease (in mother)	0.1	0.1	0.2	0.1	-0.3	0.4
Alzheimer’s Disease (in father)	0.2	0.2	0.3	0.6	0.1	0.4
Alzheimer’s Disease (including proxy)	0.1	0.2	0.4	0.6	-0.1	0.4
Crohns Disease (2017)	0.1	0.3	0.6	-0.6	-0.7	0.0
Irritable Bowel Disease (IBD)	0.1	0.2	0.6	-0.1	-0.8	0.0
Ulcerative Colitis (UC)	0.1	0.1	0.1	0.3	-0.3	-0.3
Major Depression (MDD)	0.3	0.4	0.6	0.8	-0.5	0.4
Reaction Time	0.5	0.9	1.6	0.2	1.0	1.3
Verbal and Numeric Reasoning (VNR)	0.6	1.5	2.1	1.4	0.8	-1.3
Breast Cancer	0.1	0.1	0.3	0.3	0.0	-0.5
Ovarian Cancer	1.3	1.7	2.2	1.4	1.5	-1.0
Prostate Cancer	0.2	0.3	0.9	-0.2	-0.9	0.0
Age at First Birth	2.1	3.1	4.3	-2.1	-1.6	1.6
Bipolar Disorder (2011)	1.1	1.0	1.6	0.7	1.0	-1.3
Body Mass Index (BMI) (2010)	3.6	4.9	5.5	2.0	2.3	-2.3
Coronary Artery Disease (CAD)	1.1	1.3	1.7	1.3	0.7	-1.3
Crohns Disease (2012)	0.6	1.0	1.7	1.3	0.8	-0.8
Mean Putamen Volume	1.0	1.2	2.6	0.7	0.6	-1.6
Fasting Glucose	2.1	2.5	3.6	-1.9	-1.0	1.6
HbA1C	0.2	0.3	0.5	-0.1	-0.5	0.7
HDL Cholesterol	0.1	0.1	0.4	-0.1	0.1	0.6
LDL Cholesterol	1.0	1.6	2.2	-1.1	-1.2	1.5
Lupus	5.0	7.6	9.3	-2.3	-2.9	3.0
Neuroticism (2016)	0.3	0.4	1.0	-0.3	-1.0	0.1
Primary Biliary Cirrhosis	2.6	3.7	4.7	2.2	1.4	-2.1
Rheumatoid Arthritis	0.3	0.4	1.2	1.1	-0.3	-0.0
Schizophrenia (2014)	0.1	0.3	0.5	0.0	0.7	0.7
Triglycerides	0.5	0.9	1.6	-0.5	-0.9	1.2
Type 2 Diabetes (T2D) (2012)	0.7	0.8	1.5	1.2	0.3	-0.9
Ulcerative Colitis	0.0	0.0	0.1	0.0	0.3	0.0
Blood Eosinophil Count	0.1	0.7	0.9	0.7	0.8	-0.9
Blood Platelet Count	0.0	0.5	0.9	0.5	0.6	-0.9
Blood Red Count	0.3	2.7	5.2	-1.7	-2.3	0.3
Blood White Count	0.9	6.4	8.4	2.1	2.5	-2.9
Heel T-Score	7.8	62.2	108.2	-10.4	-4.8	7.5
BMI	3.9	22.7	28.5	4.4	5.3	-4.5
Height	4.1	78.1	114.5	-8.2	-10.7	7.2
Waist Hip Ratio (WHR)	4.4	19.7	32.4	-4.3	-2.8	5.7
Systolic Blood Pressure	0.3	1.5	3.3	0.9	0.6	-1.8
Smoking Status	0.9	2.1	5.4	2.3	0.7	-0.7
Allergy or Eczema	2.6	6.8	8.8	-2.4	-2.4	3.0
Cardiovascular Disease	1.0	3.4	3.9	1.7	1.9	-2.0
Hypothyroidism (self reported)	0.7	1.5	3.3	0.8	1.8	-0.8
Respiratory disease	0.8	1.8	2.9	-1.5	-0.7	1.7
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.3	0.6	-0.4	-0.5
Lung FEV1/FVC ratio	0.1	0.3	0.9	0.3	-0.2	-0.9
Lung FVC	1.8	9.0	12.3	3.5	2.2	-3.1
Neuroticism	0.3	0.8	1.0	1.0	1.0	-0.6
Chronotype (morning person)	0.0	0.0	0.1	-0.2	-0.3	0.1
Hair Pigment	0.3	7.5	11.4	-3.1	-3.4	1.1
Tanning	0.1	1.7	2.2	1.4	0.9	-1.5
Hand grip strength (left)	1.0	2.6	3.8	-2.0	-1.8	1.0
Number of treatments/medications taken	0.4	0.6	1.6	-0.3	-0.5	1.3
Average weekly spirits intake	0.2	0.2	0.7	-0.8	0.2	0.1
Sensitivity / hurt feelings	0.9	1.6	2.4	1.5	1.3	-0.8
Frequency of depressed mood in last 2 weeks	1.1	1.5	2.2	1.5	1.5	-0.4
Hearing difficulty/problems: Yes	1.5	2.3	2.3	-1.5	-1.5	1.5
Relative age of first facial hair	0.0	0.1	0.1	-0.3	0.3	0.1
Other serious medical condition/disability diagnosed by doctor	0.1	0.2	0.3	0.5	0.4	-0.0
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.2	0.4	-0.1	0.4
Ever had hysterectomy (womb removed)	0.0	0.0	0.0	-0.2	0.1	-0.0
Systolic blood pressure, automated reading	0.9	2.7	3.4	1.4	1.8	-1.7
Eye problems/disorders: Diabetes related eye disease	0.0	0.0	0.1	0.0	-0.1	-0.3
Angina	0.2	0.3	0.6	-0.4	-0.2	0.8
Medication for hormone replacement therapy	0.1	0.1	0.2	0.4	0.2	0.2
Vitamin and mineral supplements	0.3	0.4	0.7	0.8	0.7	0.4
Supplements: Zinc	0.2	0.2	0.2	0.4	-0.5	0.5
Medication: Co-codamol	0.5	0.6	1.4	0.6	1.2	-0.3
Medication: Metformin	1.3	1.8	2.5	1.6	1.1	-1.3
Diabetes (father)	0.2	0.2	0.3	-0.4	-0.4	0.6
Diabetes (mother)	0.4	0.5	1.1	-0.5	-0.4	-1.1
Severe depression (siblings)	0.2	0.3	0.5	0.1	0.7	0.5
Pack years adult smoking proportion	0.3	0.5	1.2	1.1	0.4	0.2
Impedance of leg (right)	7.6	37.0	39.4	-6.3	-6.0	5.9
Leg fat-free mass (left)	0.6	3.4	4.9	2.2	1.0	-2.1
Trunk fat percentage	0.4	1.7	2.9	1.3	1.7	-0.5
Hand grip strength (right)	0.5	1.3	2.3	-1.5	-1.3	0.3
Townsend deprivation index at recruitment	2.2	3.1	3.7	1.9	1.9	-1.4
Current tobacco smoking	0.8	1.2	3.3	1.8	0.4	-0.4
Average weekly fortified wine intake	0.4	0.5	1.2	-0.5	-0.1	-1.1
Maternal smoking around birth	5.5	8.0	10.4	3.2	2.9	-2.2
Fed-up feelings	2.2	4.1	5.8	2.4	2.1	-1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.5	2.3	1.5	1.3	-0.6
Relative age voice broke	0.4	0.6	1.2	0.4	0.5	-1.1
Taking other prescription medications	3.1	4.8	8.8	-1.8	-1.5	3.0
Age when periods started (menarche)	5.4	12.9	20.0	-3.5	-2.5	4.5
Bilateral oophorectomy (both ovaries removed)	1.1	1.3	2.7	-0.9	-1.6	0.6
Heel bone mineral density (BMD) T-score, automated (left)	4.2	9.5	16.8	-4.1	-1.8	2.9
Tinnitus: Yes, but not now, but have in the past	0.0	0.0	0.0	0.2	-0.1	-0.2
Qualifications: CSEs or equivalent	0.3	0.4	0.6	0.4	-0.7	-0.7
Serious illness, injury or assault to yourself	0.5	0.6	1.3	1.1	0.6	-0.3
High blood pressure	0.6	1.6	1.7	1.1	1.3	-1.3
Hayfever, allergic rhinitis or eczema	2.8	6.1	8.1	-2.0	-2.5	2.8
Multivitamins +/- minerals	0.8	1.0	1.9	-1.4	-0.8	0.5
Stomach or abdominal pain in last month	1.0	1.2	1.9	1.4	1.3	0.1
Supplements: Glucosamine	6.0	7.9	9.7	-3.1	-3.1	2.1
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	0.7	-0.9	-0.6	0.8
Medication: Atenolol	0.2	0.3	0.8	0.1	0.9	-0.3
Medication: Levothyroxine sodium	0.7	1.1	1.6	1.0	1.3	-0.9
Sitting height	0.6	4.4	12.7	-0.6	-3.6	-0.1
Chronic bronchitis/emphysema (father)	1.3	1.5	2.3	1.3	1.5	0.6
High blood pressure (mother)	0.1	0.1	0.2	-0.5	-0.1	0.3
Body mass index (BMI)	5.4	22.8	28.5	4.7	5.3	-4.2
Impedance of leg (left)	7.1	34.6	36.6	-6.0	-5.8	5.8
Leg predicted mass (left)	0.7	3.5	5.1	2.3	1.0	-2.1
Trunk fat mass	0.2	1.0	1.5	1.2	1.1	-0.5
Waist circumference	0.5	1.9	4.3	1.1	2.1	-0.2
Number of incorrect matches in round	0.8	1.3	1.6	1.2	1.0	-1.2
Past tobacco smoking	0.1	0.3	0.5	-0.2	0.5	-0.7
Alcohol usually taken with meals	1.4	2.3	3.4	-1.6	-1.8	0.9
Nervous feelings	0.9	1.7	2.7	1.3	1.6	-0.9
Frequency of tenseness / restlessness in last 2 weeks	1.6	2.4	3.3	1.7	1.8	-1.0
Hearing difficulty/problems with background noise	0.3	0.5	1.3	-0.2	-0.4	1.1
Hair/balding pattern: Pattern 2	0.1	0.1	0.3	-0.6	0.0	-0.1
Had menopause	0.2	0.2	0.4	0.2	0.5	-0.6
Had other major operations	1.8	2.3	4.3	-1.2	-1.1	2.1
Forced vital capacity (FVC)	0.8	2.9	7.3	-1.0	-2.7	0.6
Heel bone mineral density (BMD) T-score, automated (right)	2.5	5.8	11.5	-3.4	-1.3	2.1
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	1.3	0.9	1.1	-0.6
Qualifications: None of the above	0.8	1.7	2.3	1.2	1.5	-1.2
Financial difficulties in last 2 years	4.3	5.7	8.7	3.0	2.4	-1.6
Mouth/teeth dental problems	1.2	1.8	4.0	-1.2	-2.0	0.1
Heart attack	2.4	3.1	5.2	1.1	2.3	-1.7
Allergy	1.6	3.8	4.8	1.8	2.2	-1.8
Pain all over the body in last month	2.9	3.1	5.7	2.4	1.6	-1.0
Diabetes (self-reported)	0.3	0.4	0.7	-0.2	-0.8	0.7
Hayfever/allergic rhinitis (self-reported)	2.7	3.6	4.4	-1.6	-1.9	2.1
Medication: Ramipril	0.2	0.3	0.7	0.1	0.8	0.2
Medication: Simvastatin	0.7	1.0	1.2	0.9	1.1	-1.0
Fluid intelligence score	0.4	0.8	1.8	0.1	0.6	-1.4
Illnesses of siblings	1.7	2.4	4.0	-1.3	-2.0	1.2
Neuroticism score	0.2	0.4	0.9	0.9	0.5	-0.1
Weight	0.4	2.2	3.1	1.8	1.2	-1.4
Impedance of arm (right)	4.0	18.8	21.3	-4.5	-3.9	4.6
Arm fat percentage (right)	2.8	11.1	16.5	3.2	4.1	-2.5
Trunk fat-free mass	0.2	0.9	2.3	0.2	-1.5	-0.6
Hip circumference	1.6	7.1	8.0	2.8	2.8	-2.3
Time employed in main current job	0.3	0.3	0.6	0.5	-0.0	-0.8
Alcohol intake versus 10 years previously	1.1	1.6	3.3	-0.4	-1.2	1.8
Father’s age at death	1.5	2.0	2.6	-1.1	-1.6	1.5
Worrier / anxious feelings	0.4	0.8	1.1	-0.8	-0.7	1.1
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.7	2.8	1.7	1.4	-0.5
Falls in the last year	0.1	0.1	0.2	0.2	-0.3	0.5
Hair/balding pattern: Pattern 3	1.0	1.5	2.1	1.5	1.3	-0.9
Number of live births	1.2	1.8	2.1	1.3	1.5	-1.3
Forced expiratory volume in 1-second (FEV1)	0.4	1.5	4.1	-0.6	-2.0	-0.1
Pulse rate	2.9	5.0	6.9	-2.3	-1.7	2.6
Happiness	0.0	0.0	0.1	-0.1	-0.0	0.3
Noisy workplace	0.3	0.4	0.6	0.8	0.6	0.3
Qualifications: A levels/AS levels or equivalent	0.3	0.6	1.3	-0.5	-1.2	-0.4
Serious illness, injury or assault of a close relative in last 2 years	0.0	0.0	0.1	0.3	0.1	0.2
Mouth/teeth dental problems: Dentures	2.0	3.3	5.2	1.7	2.3	-1.4
Asthma	0.5	1.1	1.3	-1.1	-0.8	1.1
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	1.2	1.0	0.9	-1.1
Medication: Cholesterol lowering	1.0	1.5	2.2	1.5	1.2	-1.0
Depression (self-reported)	0.8	0.9	2.7	0.2	-0.4	1.6
Medication: Lansoprazole	0.1	0.1	0.2	-0.1	-0.5	0.4
Prospective memory result	0.5	0.6	1.0	-0.1	-1.0	1.0
Lung cancer (father)	3.8	4.5	5.9	2.4	2.3	-1.6
Illnesses of mother	1.6	2.0	3.4	-1.2	-1.9	1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.1	2.9	-0.5	-1.7	-0.5
Pulse wave Arterial Stiffness index	0.4	0.5	1.5	0.1	-1.2	0.0
Impedance of arm (left)	3.6	16.7	17.9	-4.1	-3.9	4.2
Arm fat mass (right)	1.6	6.4	8.2	2.6	2.9	-2.1
Trunk predicted mass	0.2	0.9	2.4	0.1	-1.5	-0.6
Standing height	4.6	45.3	72.9	-6.0	-8.5	5.2
Length of working week for main job	0.5	0.5	0.8	-0.9	-0.7	0.5
Exposure to tobacco smoke at home	0.3	0.4	0.6	0.5	0.8	-0.5
Breastfed as a baby	0.5	0.6	1.6	0.3	0.2	-1.3
Tense / ‘highly strung’	0.6	1.0	2.0	-0.7	-0.5	1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	0.6	0.7	0.2	0.8
Hair/balding pattern: Pattern 4	0.1	0.3	0.5	0.7	-0.7	0.2
Birth weight of first child	6.8	12.3	14.0	-3.5	-3.7	3.2
Peak expiratory flow (PEF)	0.1	0.3	0.5	-0.0	-0.6	-0.7
Pulse wave reflection index	0.7	0.8	1.4	1.2	0.3	-1.0
Ever highly irritable/argumentative for 2 days	1.7	2.0	2.8	-1.2	-1.7	1.3
Loud music exposure frequency	2.2	2.4	3.3	1.8	1.8	-0.9
Qualifications: O levels/GCSEs or equivalent	0.8	1.2	2.5	-1.1	-1.6	0.1
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.4	0.1	0.6	0.0
Blood clot in the leg (DVT)	0.8	1.0	2.4	0.5	0.6	-1.6
Medication: Paracetamol	0.2	0.3	0.4	0.7	0.6	0.3
Headache pain in last month	0.1	0.1	0.4	0.0	-0.6	-0.0
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	1.9	-1.4	-0.8	0.8
Glaucoma (self-reported)	0.7	0.8	1.0	-0.8	-0.9	1.0
Gout (self-reported)	0.5	0.7	1.2	0.8	1.1	-0.4
Hypothyroidism/myxoedema (self-reported)	0.1	0.3	0.6	0.3	0.8	-0.3
Medication: Amlodipine	0.6	0.9	1.6	-0.7	-1.3	0.8
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.2	-0.3	-0.4	-0.2
Birth weight	7.1	15.4	25.9	-3.9	-2.4	5.1
Chronic bronchitis/emphysema (mother)	3.3	3.8	5.1	2.3	2.2	-1.3
High blood pressure (siblings)	0.9	1.3	2.1	0.8	1.4	-1.1
Forced vital capacity (FVC), Best measure	0.8	3.1	7.3	-1.3	-2.7	0.6
Body fat percentage	0.7	2.9	4.8	1.8	2.2	-0.9
Leg fat percentage (right)	0.8	3.0	5.6	1.6	2.4	-0.9
Arm fat-free mass (right)	0.2	0.8	1.3	0.9	-0.6	-1.1
Exposure to tobacco smoke outside home	0.5	0.7	1.1	0.8	1.1	-0.6
Comparative body size at age 10	0.2	0.6	1.1	0.6	0.5	-1.1
Number of full brothers	6.5	8.1	11.5	3.4	2.4	-2.6
Worry too long after embarrassment	0.1	0.2	0.5	-0.4	0.1	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	1.9	1.4	0.7	0.2
Wheeze or whistling in the chest in last year	0.4	0.7	1.5	0.7	-0.4	-1.2
Number of children fathered	1.2	1.3	2.0	1.2	0.6	-1.4
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.0	0.9	1.0	-0.1
Age at first live birth	3.1	5.4	6.5	-2.6	-2.5	1.8
Pulse wave peak to peak time	0.2	0.3	0.5	-0.5	0.7	0.2
Health satisfaction	0.1	0.1	0.1	-0.2	-0.3	0.3
Shortness of breath walking on level ground	0.6	0.7	1.5	-0.6	-1.2	0.3
Qualifications: College or University degree	0.1	0.2	0.3	-0.5	-0.5	-0.3
Eye problems/disorders: None of the above	0.3	0.4	1.0	-0.2	0.4	-1.0
Mouth/teeth dental problems: Loose teeth	0.4	0.5	0.9	0.9	0.7	-0.2
Emphysema/chronic bronchitis	4.4	4.9	7.6	2.8	1.7	-2.1
Medication for pain relief, constipation, heartburn	1.7	2.9	4.9	-1.8	-2.2	0.9
Neck or shoulder pain in last month	0.6	0.8	1.1	-1.1	-0.5	1.0
Medication: Blood pressure	0.1	0.1	0.2	0.3	0.1	-0.4
Angina (self-reported)	0.3	0.4	1.0	-0.6	-0.1	1.0
Migraine (self-reported)	0.5	0.6	1.7	1.3	0.4	-0.4
Medication: Ibuprofen	0.8	0.9	1.1	1.0	0.8	-1.0
Medication: Allopurinol	0.2	0.2	0.4	-0.2	0.6	-0.6
Medication: Omeprazole	0.3	0.4	0.9	0.9	0.4	-0.1
Medication: Seretide 50 evohaler	0.7	0.8	1.6	1.3	-0.2	-0.9
Mean time to correctly identify matches	0.5	1.0	1.4	0.6	1.2	1.1
Heart disease (mother)	2.9	3.6	5.8	1.7	2.4	-1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	4.1	4.9	6.6	2.1	2.6	-1.9
Whole body fat mass	0.5	1.9	2.5	1.6	1.5	-1.0
Leg fat mass (right)	0.9	3.4	4.5	2.0	2.1	-1.3
Arm predicted mass (right)	0.1	0.7	1.0	0.5	-0.9	-1.0
Pulse rate, automated reading	0.2	0.5	0.8	-0.9	0.3	0.8
Alcohol intake frequency.	0.1	0.2	0.3	0.6	-0.3	0.5
Comparative height size at age 10	4.0	22.0	37.0	-4.0	-6.1	3.6
Number of full sisters	4.6	5.6	7.2	2.7	2.4	-1.9
Suffer from ‘nerves’	0.1	0.2	0.4	-0.3	0.1	0.6
Overall health rating	0.5	1.0	1.9	1.0	1.4	-0.0
Chest pain or discomfort	0.9	1.4	2.2	1.5	1.1	-0.9
Had major operations	2.7	3.2	4.1	2.0	1.3	-2.0
Age at last live birth	1.1	1.6	2.2	-1.3	-1.5	1.0
Family relationship satisfaction	0.2	0.3	0.8	0.2	0.9	0.1
Leg pain on walking	0.2	0.3	0.6	0.8	0.4	-0.1
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	2.2	1.5	0.9	-0.8
Commuting to job workplace: Car/motor vehicle	2.6	3.0	3.4	-1.8	-1.6	1.8
Illness, injury, bereavement, stress in last 2 years	2.4	2.9	3.4	-1.8	-1.7	1.6
Medication: Aspirin	0.8	1.1	3.0	0.5	1.7	-0.2
Supplements: Vitamin C	0.2	0.2	0.5	-0.7	-0.4	-0.0
Knee pain experienced in last month	0.4	0.6	0.7	-0.8	-0.7	0.7
Hypertension (Self-reported)	0.3	0.7	0.9	0.6	0.9	-0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.5	3.1	-1.1	-1.7	0.5
Illnesses of father: Heart disease	0.1	0.2	0.3	-0.5	-0.5	0.1
Illnesses of siblings: Diabetes	0.9	1.1	1.6	0.9	1.0	-1.3
Smoking status: Previous	0.0	0.1	0.2	0.0	0.1	0.4
Forced expiratory volume in 1-second (FEV1), predicted	1.9	3.9	8.1	-1.9	-2.8	0.3
Whole body fat-free mass	0.1	0.8	1.2	1.0	-0.6	-1.1
Leg fat-free mass (right)	0.7	3.6	5.4	2.3	0.9	-2.1
Arm fat percentage (left)	2.7	10.7	15.6	3.3	3.9	-2.4
Average weekly red wine intake	0.1	0.2	0.3	-0.3	-0.5	-0.5
Handedness (chirality/laterality): Left-handed	7.1	8.5	9.5	3.0	2.6	-3.1
Mood swings	0.3	0.6	1.2	1.1	0.6	-0.4
Loneliness, isolation	1.7	2.3	2.9	1.7	1.6	-1.2
Long-standing illness, disability or infirmity	0.1	0.1	0.2	0.3	0.1	0.5
Ever had bowel cancer screening	0.3	0.4	0.4	0.6	0.7	0.6
Diabetes diagnosed by doctor	0.1	0.2	0.5	0.0	-0.7	0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	1.8	-1.3	-0.5	1.0
Friendships satisfaction	0.7	0.9	1.1	1.0	0.8	-0.9
Qualifications: nursing, teaching	0.1	0.1	0.2	0.4	0.0	0.4
Commuting to job workplace: Walk	3.7	4.0	7.5	2.7	1.3	-1.7
Eye problems/disorders: Cataract	0.8	0.9	1.5	-0.2	-1.1	1.2
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	3.1	-0.7	-0.8	1.8
Medication for cholesterol	0.5	0.8	1.0	-0.8	-1.0	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	7.1	8.3	13.6	3.7	2.8	-1.9
Back pain experienced in last month	0.4	0.6	1.2	-1.1	-0.2	0.7
Mineral and other dietary supplements	8.6	11.5	15.8	3.2	2.9	-4.0
Breast cancer (self-reported)	0.4	0.5	0.9	-0.2	-0.9	0.8
Asthma (self-reported)	0.5	1.0	1.4	-1.1	-0.7	1.2
Osteoporosis (self-reported)	0.3	0.3	0.7	0.4	-0.9	0.3
Osteoarthritis (self-reported)	0.2	0.3	0.6	0.5	0.8	0.2
Medication: Aspirin	0.7	0.9	2.5	0.3	1.6	0.2
Medication: Gliclazide	0.3	0.3	0.4	-0.4	-0.5	0.7
Illnesses of father: None of the above (group 1)	0.3	0.4	0.5	0.6	0.6	-0.7
Smoking status: Current	0.6	0.9	2.6	1.6	0.1	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.9	3.2	1.0	1.2	-1.8
Whole body water mass	0.2	1.0	1.6	1.1	-0.5	-1.2
Leg predicted mass (right)	0.7	3.8	5.7	2.4	1.0	-2.1
Arm fat mass (left)	1.8	7.6	9.2	2.9	3.0	-2.3
Number of self-reported non-cancer illnesses	0.2	0.3	0.4	0.1	-0.6	0.6
Average weekly champagne plus white wine intake	0.1	0.1	0.1	-0.0	0.4	-0.3
Miserableness	0.5	0.9	1.4	-0.2	-1.1	1.2
Guilty feelings	0.5	0.8	1.7	0.9	1.3	0.1
Wears glasses or contact lenses	1.4	1.6	2.1	1.4	1.4	-0.9
Ever taken oral contraceptive pill	0.3	0.4	1.0	-0.3	-1.0	-0.1
Hearing aid user	0.7	0.8	1.2	1.1	0.6	-0.9
Mother’s age at death	0.8	1.0	1.4	-1.2	-1.2	0.4
Financial situation satisfaction	0.7	0.9	1.8	1.3	0.8	-0.4
Tinnitus: Yes, now most or all of the time	1.0	1.2	2.4	-1.6	-0.8	0.7
Commuting to job workplace: Public transport	2.9	3.5	3.8	1.9	1.7	-2.0
Eye problems/disorders: Glaucoma	0.5	0.6	1.2	-0.4	-0.5	1.1
Medication: Blood pressure	0.0	0.1	0.1	0.1	0.3	-0.3
Pain type(s) experienced in last month: Hip pain	1.3	1.7	3.7	-0.8	-0.9	1.9
Supplements: Fish oil (including cod liver oil)	5.1	6.6	9.4	-2.5	-2.1	3.1
High cholesterol (Self-reported)	0.7	1.2	2.0	1.1	1.4	-0.7
Medication: Bendroflumethiazide	0.8	1.1	2.0	1.4	0.6	-1.0
Medication: Paracetamol	0.1	0.2	0.2	0.5	0.3	0.4
Medication: Lisinopril	0.4	0.5	0.7	0.8	0.5	-0.8
Medication: Atorvastatin	0.2	0.2	0.7	0.1	0.1	0.8
Illnesses of father: High blood pressure	0.7	0.8	2.0	-0.7	-1.4	-0.1
Alcohol drinker status: Never	0.1	0.1	0.2	-0.1	0.4	0.2
Ever smoked	0.7	1.3	2.1	-0.5	-1.5	1.3
Basal metabolic rate	0.2	1.1	1.7	1.2	-0.1	-1.3
Leg fat percentage (left)	0.9	3.3	6.2	1.6	2.5	-1.0
Arm fat-free mass (left)	0.1	0.6	1.2	0.6	-0.5	-1.1
Number of operations (self-reported)	0.1	0.2	0.4	0.1	-0.3	0.6
Average weekly beer plus cider intake	0.8	1.2	2.5	0.9	1.6	-0.4
Irritability	0.2	0.3	0.8	0.9	0.0	-0.2
Risk taking	0.2	0.3	0.5	0.5	-0.1	0.7
Ever had prostate specific antigen (PSA) test	1.3	1.5	2.0	-1.3	-1.4	0.9
Fractured/broken bones in last 5 years	0.5	0.7	1.4	-0.8	-1.2	0.2
Age started oral contraceptive pill	0.8	0.9	1.2	-1.1	-0.9	0.9
Diastolic blood pressure, automated reading	1.5	4.6	6.6	2.0	2.6	-1.8
Ever depressed for a whole week	0.3	0.4	0.8	0.9	0.6	-0.1
Unable to work because of sickness or disability	2.5	3.2	5.5	2.4	1.6	-1.2
Commuting to job workplace: Cycle	1.0	1.3	1.9	-1.1	-1.4	0.8
Myopia	0.2	0.3	0.7	0.1	0.5	-0.8
Vascular/heart problems diagnosed by doctor	0.6	1.5	2.1	-1.1	-1.5	1.1
Cholesterol lowering medication	0.3	0.4	0.6	0.7	0.8	0.2
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.1	0.3	-0.2	0.3
Pain experienced in last month	0.5	0.8	1.0	1.0	0.7	-1.0
Supplements: Calcium	2.0	2.2	4.7	-0.6	-2.2	1.2
Basal cell carcinoma (self-reported)	0.3	0.3	0.9	0.1	0.0	1.0
Heart attack/myocardial infarction (self-reported)	2.8	3.6	6.0	1.2	2.4	-1.8
Deep venous thrombosis (DVT) (self-reported)	0.9	1.1	2.7	0.6	0.5	-1.7
Heart disease (siblings)	1.6	2.0	3.2	1.3	1.8	-1.1
Alcohol drinker status: Previous	0.7	0.8	2.3	1.5	-0.3	-0.4
Pack years of smoking	0.1	0.2	0.5	0.7	0.1	0.4
Impedance of whole body	5.3	27.0	27.8	-5.3	-5.2	5.2
Leg fat mass (left)	0.7	2.8	4.0	1.8	2.0	-1.1
Arm predicted mass (left)	0.2	0.8	1.4	0.8	-0.5	-1.2