Best TWAS P=8.26e-15 · Best GWAS P=8.48e-18 conditioned to 0.399
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | SOX15 | 0.04 | 0.01 | lasso | 3 | 0.01 | 2.8e-02 | 6.09 | -5.9 | 3.7e-09 | -0.72 | 0.15 | 0.18 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | CHRNB1 | 0.29 | 0.14 | lasso | 5 | 0.14 | 1.0e-07 | 5.22 | 5.9 | 2.9e-09 | 0.41 | 0.96 | 0.00 | FALSE |
| 3 | GTEx | Artery Tibial | KDM6B | 0.14 | 0.02 | enet | 22 | 0.03 | 1.4e-03 | -3.15 | 5.5 | 3.3e-08 | 0.33 | 0.18 | 0.35 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | TNFSF12 | 0.25 | 0.22 | lasso | 8 | 0.20 | 7.4e-15 | -5.76 | -6.1 | 9.7e-10 | -0.51 | 1.00 | 0.00 | TRUE |
| 5 | GTEx | Esophagus Mucosa | KCNAB3 | 0.20 | 0.12 | lasso | 9 | 0.08 | 3.1e-06 | -4.23 | 5.2 | 2.6e-07 | 0.24 | 0.99 | 0.00 | TRUE |
| 6 | GTEx | Esophagus Mucosa | CHRNB1 | 0.19 | 0.11 | lasso | 2 | 0.13 | 7.3e-09 | 5.22 | 5.8 | 6.9e-09 | 0.41 | 1.00 | 0.00 | FALSE |
| 7 | GTEx | Esophagus Mucosa | ZBTB4 | 0.12 | 0.10 | lasso | 2 | 0.08 | 8.0e-06 | 5.40 | 5.3 | 9.2e-08 | 0.35 | 0.96 | 0.00 | FALSE |
| 8 | GTEx | Heart Left Ventricle | CHRNB1 | 0.16 | 0.03 | lasso | 4 | 0.05 | 9.6e-04 | -5.30 | 5.3 | 1.4e-07 | 0.39 | 0.09 | 0.38 | FALSE |
| 9 | GTEx | Lung | CNTROB | 0.15 | 0.06 | enet | 28 | 0.07 | 9.5e-06 | -4.56 | 5.6 | 2.2e-08 | 0.29 | 0.52 | 0.20 | FALSE |
| 10 | GTEx | Prostate | AC113189.5 | 0.43 | 0.02 | lasso | 5 | 0.01 | 2.0e-01 | 6.07 | -7.0 | 2.4e-12 | -0.66 | 0.05 | 0.29 | FALSE |
| 11 | GTEx | Skin Not Sun Exposed Suprapubic | CHRNB1 | 0.17 | 0.15 | lasso | 3 | 0.16 | 7.4e-09 | 5.22 | 6.0 | 1.5e-09 | 0.44 | 1.00 | 0.00 | FALSE |
| 12 | GTEx | Skin Sun Exposed Lower leg | ATP1B2 | 0.08 | 0.01 | lasso | 3 | 0.01 | 4.8e-02 | 4.51 | 5.5 | 3.5e-08 | 0.66 | 0.06 | 0.84 | FALSE |
| 13 | GTEx | Skin Sun Exposed Lower leg | CHRNB1 | 0.19 | 0.12 | enet | 13 | 0.12 | 3.0e-10 | 5.18 | 5.2 | 2.3e-07 | 0.37 | 1.00 | 0.00 | FALSE |
| 14 | GTEx | Whole Blood | TNFSF12 | 0.09 | 0.03 | enet | 24 | 0.04 | 1.9e-04 | -5.82 | -5.4 | 8.0e-08 | -0.50 | 0.64 | 0.16 | FALSE |
| 15 | METSIM | Adipose | ACAP1 | 0.06 | 0.03 | blup | 452 | 0.03 | 2.5e-05 | 2.76 | 5.7 | 1.2e-08 | 0.37 | 0.19 | 0.67 | FALSE |
| 16 | NTR | Blood | TNFSF12 | 0.06 | 0.07 | bslmm | 462 | 0.07 | 9.4e-23 | -5.15 | -6.8 | 9.1e-12 | -0.53 | 1.00 | 0.00 | FALSE |
| 17 | ROSMAP | Brain Pre-frontal Cortex | YBX2 | 0.11 | 0.10 | bslmm | 442 | 0.10 | 2.5e-12 | 5.08 | 6.8 | 8.1e-12 | 0.25 | 1.00 | 0.00 | TRUE |
| 18 | ROSMAP | Brain Pre-frontal Cortex | FGF11 | 0.08 | 0.04 | blup | 454 | 0.04 | 1.2e-05 | -5.30 | 7.8 | 8.3e-15 | 0.59 | 0.98 | 0.01 | TRUE |
| 19 | ROSMAP | Brain Pre-frontal Cortex | CHRNB1 | 0.11 | 0.08 | lasso | 6 | 0.08 | 7.8e-11 | 5.22 | 6.4 | 1.5e-10 | 0.43 | 1.00 | 0.00 | FALSE |
| 20 | ROSMAP | Brain Pre-frontal Cortex | SLC16A11 | 0.08 | 0.00 | blup | 473 | 0.02 | 5.8e-04 | -1.68 | 5.8 | 5.2e-09 | 0.33 | 0.04 | 0.29 | TRUE |
| 21 | YFS | Blood | CHRNB1 | 0.04 | 0.02 | lasso | 5 | 0.04 | 8.5e-12 | 5.03 | 5.8 | 5.9e-09 | 0.43 | 1.00 | 0.00 | FALSE |
| 22 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CHRNB1 | 0.06 | 0.06 | enet | 10 | 0.06 | 1.0e-11 | 5.03 | 5.3 | 1.4e-07 | 0.40 | 0.86 | 0.14 | FALSE |
| 23 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | CHRNB1 | 0.07 | 0.04 | blup | 57 | 0.05 | 1.6e-03 | 5.22 | 6.6 | 3.7e-11 | 0.47 | 0.01 | 0.71 | FALSE |
| 24 | The Cancer Genome Atlas | Glioblastoma Multiforme | AMAC1L3 | 0.14 | 0.12 | lasso | 3 | 0.12 | 1.8e-04 | 6.21 | -5.7 | 1.1e-08 | -0.50 | 0.02 | 0.64 | FALSE |
| 25 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | CHRNB1 | 0.06 | 0.07 | lasso | 6 | 0.07 | 1.8e-08 | 6.29 | 7.2 | 8.8e-13 | 0.52 | 0.01 | 0.99 | FALSE |
| 26 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CHRNB1 | 0.04 | 0.03 | blup | 57 | 0.02 | 1.5e-03 | -6.23 | 6.7 | 1.7e-11 | 0.49 | 0.01 | 0.87 | FALSE |
| 27 | The Cancer Genome Atlas | Brain Lower Grade Glioma | AMAC1L3 | 0.04 | 0.02 | blup | 54 | 0.02 | 3.9e-03 | 6.50 | -6.0 | 1.5e-09 | -0.37 | 0.02 | 0.95 | FALSE |
| 28 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SHBG | 0.05 | 0.02 | lasso | 3 | 0.02 | 8.1e-04 | 6.07 | -6.6 | 3.8e-11 | -0.82 | 0.01 | 0.94 | FALSE |
| 29 | The Cancer Genome Atlas | Lung Adenocarcinoma | CHRNB1 | 0.03 | 0.02 | blup | 57 | 0.02 | 7.8e-04 | 5.03 | 7.5 | 5.6e-14 | 0.54 | 0.05 | 0.89 | FALSE |
| 30 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | ATP1B2 | 0.13 | 0.01 | blup | 42 | 0.02 | 6.3e-02 | -2.73 | 5.5 | 5.0e-08 | 0.43 | 0.01 | 0.14 | FALSE |
| 31 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SHBG | 0.04 | 0.01 | blup | 60 | 0.03 | 5.4e-04 | -2.73 | -5.4 | 8.1e-08 | -0.58 | 0.01 | 0.64 | FALSE |
| 32 | The Cancer Genome Atlas | Prostate Adenocarcinoma | TNFSF12-TNFSF13 | 0.03 | 0.00 | lasso | 4 | 0.01 | 2.9e-02 | -5.76 | -6.6 | 3.2e-11 | -0.56 | 0.02 | 0.23 | FALSE |
| 33 | The Cancer Genome Atlas | Soft Tissue Sarcoma | CHRNB1 | 0.07 | 0.03 | enet | 8 | 0.03 | 6.9e-03 | 6.26 | 6.3 | 2.7e-10 | 0.51 | 0.01 | 0.55 | FALSE |
| 34 | The Cancer Genome Atlas | Stomach Adenocarcinoma | CHRNB1 | 0.06 | 0.00 | blup | 57 | 0.03 | 4.5e-03 | -0.92 | 6.5 | 1.1e-10 | 0.53 | 0.01 | 0.40 | FALSE |
| 35 | The Cancer Genome Atlas | Thyroid Carcinoma | CHRNB1 | 0.09 | 0.02 | blup | 57 | 0.05 | 2.6e-05 | -5.30 | 6.4 | 1.5e-10 | 0.49 | 0.04 | 0.91 | FALSE |
| 36 | The Cancer Genome Atlas | Thyroid Carcinoma | TNFSF13 | 0.11 | 0.00 | enet | 7 | 0.03 | 3.5e-04 | -5.76 | 5.1 | 3.1e-07 | 0.38 | 0.02 | 0.04 | FALSE |