TWAS hub - KCNAB3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.0940	0.0330	1.8e-04	0.082	NA	0.045	NA	0.050	2.9e-07	NA	1.4e-04	NA	5.8e-05
2	GTEx	Brain Cerebellar Hemisphere	0.5390	0.1010	5.7e-07	0.349	NA	0.254	NA	0.301	8.1e-10	NA	3.3e-07	NA	1.9e-08
3	GTEx	Brain Cerebellum	0.3440	0.0730	1.2e-06	0.326	NA	0.246	NA	0.342	2.2e-10	NA	6.9e-08	NA	6.8e-11
4	GTEx	Esophagus Mucosa	0.2020	0.0530	1.2e-06	0.118	NA	0.078	NA	0.084	3.0e-08	NA	7.0e-06	NA	3.1e-06
5	GTEx	Lung	0.1398	0.0395	1.0e-05	0.054	NA	0.022	NA	0.043	5.6e-05	NA	7.6e-03	NA	2.9e-04
6	GTEx	Nerve Tibial	0.1666	0.0441	2.4e-06	0.111	NA	0.072	NA	0.095	3.1e-08	NA	8.5e-06	NA	3.1e-07
7	GTEx	Pancreas	0.1580	0.0560	1.2e-03	0.072	NA	0.119	NA	0.097	5.7e-04	NA	1.0e-05	NA	7.2e-05
8	GTEx	Thyroid	0.1460	0.0380	5.8e-07	0.135	NA	0.121	NA	0.099	1.7e-10	NA	1.6e-09	NA	5.3e-08
9	METSIM	Adipose	0.0565	0.0174	5.5e-06	0.045	0.037	0.040	0.038	0.018	2.5e-07	2.3e-06	1.0e-06	1.9e-06	9.6e-04
10	ROSMAP	Brain Pre-frontal Cortex	0.0664	0.0185	2.7e-07	0.084	0.042	0.080	0.057	0.066	5.4e-11	3.6e-06	1.5e-10	7.0e-08	6.5e-09
11	TCGA	Brain Lower Grade Glioma	0.0219	0.0129	1.2e-03	0.013	0.016	0.006	NA	0.004	1.2e-02	5.4e-03	6.5e-02	NA	1.1e-01
12	TCGA	Prostate Adenocarcinoma	0.0313	0.0191	9.1e-04	0.008	0.027	0.019	NA	0.013	4.2e-02	7.0e-04	4.3e-03	NA	1.5e-02
13	TCGA	Thyroid Carcinoma	0.0260	0.0170	5.8e-03	0.014	0.020	0.019	NA	0.012	1.4e-02	4.7e-03	5.5e-03	NA	2.2e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Average weekly fortified wine intake	7.9	9.2	12.3	3.1	3.1	3.3	3.0	3.1	2.7	3.3	3.2	2.5	3.5	3.3	2.1	2.8
Smoking Status	7.1	16.9	28.7	3.7	3.6	3.6	3.6	4.1	4.7	3.5	3.5	4.4	4.3	4.4	4.4	5.4
Average weekly red wine intake	6.9	10.2	17.4	3.1	3.2	2.8	3.0	3.2	3.0	2.9	2.8	4.2	3.3	3.3	2.9	3.5
Myopia	6.7	9.7	13.6	-3.1	-3.6	-3.2	-3.7	-3.2	-2.9	-2.7	-3.4	-2.1	-2.7	-3.0	-3.4	-3.1
Average weekly spirits intake	6.2	7.7	10.4	2.9	2.7	2.6	2.7	2.9	2.8	2.7	2.8	2.3	3.2	3.0	2.2	3.0
Medication: Bendroflumethiazide	6.0	9.0	12.0	-3.1	-2.3	-2.6	-3.0	-2.8	-3.3	-2.6	-3.3	-3.3	-2.8	-3.5	-3.1	-3.2
Diabetes (mother)	5.9	7.5	11.9	-2.9	-2.8	-3.0	-2.4	-2.8	-2.6	-3.5	-2.5	-2.3	-2.5	-2.8	-2.7	-2.8
Current tobacco smoking	5.3	8.7	11.8	2.7	2.9	2.6	2.5	3.1	3.4	2.8	2.8	2.9	3.0	2.9	3.3	3.3
Alcohol usually taken with meals	5.2	8.4	10.8	3.0	3.2	3.3	3.1	3.0	2.4	2.9	3.0	2.9	2.8	3.2	2.1	2.7
Smoking status: Current	5.0	7.9	10.7	2.5	2.7	2.5	2.4	3.0	3.2	2.6	2.7	2.8	2.9	2.7	3.0	3.3
High blood pressure (siblings)	4.7	6.7	9.4	-2.5	-2.1	-2.5	-2.7	-2.5	-2.6	-2.8	-2.8	-2.6	-2.1	-2.9	-2.4	-3.1
Mother’s age at death	4.5	5.6	7.5	2.4	2.7	2.7	2.4	2.4	2.0	2.4	2.3	2.2	2.6	2.7	1.6	2.2
Medication: Blood pressure	4.5	8.6	15.0	-3.0	-2.2	-2.1	-3.3	-3.1	-2.7	-3.1	-3.9	-2.0	-2.8	-3.6	-2.2	-3.4
Other serious medical condition/disability diagnosed by doctor	4.4	5.8	8.5	-2.4	-2.5	-2.6	-2.2	-2.3	-2.3	-2.4	-2.2	-2.9	-2.4	-2.5	-2.0	-2.6
Maternal smoking around birth	4.4	6.4	9.0	2.3	2.1	2.2	2.7	2.5	3.0	1.9	2.3	2.1	2.7	2.7	2.9	3.0
Blood Red Count	4.2	40.5	61.0	-6.4	-6.3	-6.5	-5.6	-5.6	-6.3	-7.8	-5.3	-5.0	-6.0	-7.6	-6.1	-7.5
Impedance of arm (right)	4.2	19.5	25.4	4.3	4.4	4.5	3.1	4.3	4.9	4.3	3.6	4.8	4.0	4.8	5.0	5.0
Medication: Allopurinol	4.1	5.5	7.0	-2.3	-2.5	-2.5	-2.5	-2.3	-2.2	-2.3	-2.4	-2.6	-1.5	-2.6	-2.3	-2.0
Commuting to job workplace: Car/motor vehicle	3.9	4.5	7.1	-2.1	-1.7	-1.8	-2.1	-2.3	-2.5	-2.7	-1.9	-2.1	-1.9	-1.9	-2.4	-1.9
Breast Cancer	3.8	9.3	13.0	3.0	2.7	2.4	3.0	3.0	3.0	2.7	3.0	3.6	3.4	3.6	2.8	3.1
Waist Hip Ratio (WHR)	3.7	16.5	26.5	4.3	4.1	4.3	5.2	4.2	4.1	3.2	4.5	1.9	3.9	4.2	4.2	3.7
Verbal and Numeric Reasoning (VNR)	3.5	8.3	12.1	-2.4	-2.7	-2.7	-2.9	-2.9	-3.2	-1.8	-3.1	-3.5	-2.6	-2.6	-3.3	-3.3
Prostate Cancer	3.4	4.8	13.8	-1.7	-2.0	-2.1	-1.2	-1.6	-3.1	-1.8	-2.1	-2.5	-1.7	-1.8	-3.7	-2.2
Taking other prescription medications	3.4	5.2	8.1	-2.2	-2.5	-2.6	-2.4	-2.2	-2.0	-2.9	-2.4	-1.5	-2.0	-2.5	-1.8	-2.4
Impedance of arm (left)	3.4	15.8	21.1	3.8	4.0	4.0	2.7	3.9	4.5	3.8	3.4	4.6	3.6	4.2	4.5	4.3
Medication for cholesterol	3.4	5.2	9.3	2.5	1.5	1.5	2.6	2.5	2.4	2.8	3.0	1.3	2.1	2.4	1.9	2.4
Commuting to job workplace: Public transport	3.4	4.1	6.4	2.2	1.7	1.8	1.9	2.2	2.3	2.5	1.9	1.5	2.0	1.8	2.3	1.8
Schizophrenia vs Biploar Disorder	3.3	4.3	7.6	1.8	1.4	1.2	2.1	2.1	2.5	1.9	2.3	1.8	2.0	2.3	2.5	2.8
Body Mass Index (BMI) (2010)	3.3	4.6	6.8	-2.2	-2.2	-2.3	-2.4	-2.1	-2.1	-1.7	-1.9	-1.8	-2.2	-2.6	-1.7	-2.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.3	7.0	9.4	-2.7	-2.6	-2.8	-2.7	-2.6	-2.8	-3.1	-2.1	-2.1	-2.2	-2.8	-2.9	-2.9
Schizophrenia (2014)	3.2	7.1	13.6	2.5	2.0	2.0	2.6	2.7	3.0	2.6	2.8	2.3	1.9	2.8	3.1	3.7
Frequency of unenthusiasm / disinterest in last 2 weeks	3.2	4.2	5.7	-2.2	-2.1	-2.2	-2.1	-2.1	-1.4	-2.4	-2.1	-2.3	-2.3	-2.3	-1.1	-1.8
Illnesses of siblings	3.2	4.6	5.8	2.3	2.0	2.1	2.0	2.1	2.3	2.4	2.1	2.0	2.0	2.4	1.8	2.3
Lung cancer (father)	3.2	3.7	4.7	-1.7	-1.7	-1.9	-1.9	-2.0	-1.9	-1.7	-2.0	-2.2	-2.1	-1.9	-1.8	-1.9
Tense / ‘highly strung’	3.1	5.2	6.5	-2.1	-2.1	-2.3	-2.6	-2.4	-2.3	-2.1	-2.5	-1.7	-2.2	-2.5	-2.2	-2.3
Ever smoked	3.0	5.3	10.4	2.1	2.0	1.8	2.2	2.3	2.4	1.7	1.7	3.2	2.4	2.5	2.2	3.0
Ever unenthusiastic/disinterested for a whole week	2.8	3.4	4.7	2.1	1.9	1.8	2.0	2.2	2.1	1.7	2.0	1.3	1.6	1.5	2.0	1.6
Cholesterol lowering medication	2.8	4.1	6.8	-2.1	-1.3	-1.3	-2.2	-2.2	-2.3	-2.5	-2.4	-0.9	-1.3	-2.1	-2.0	-2.6
Schizophrenia (2018)	2.7	5.5	11.2	2.2	1.4	1.3	2.3	2.4	2.9	2.2	2.6	2.3	1.6	2.3	2.8	3.3
Noisy workplace	2.7	3.3	5.4	-1.8	-1.0	-1.2	-1.6	-1.7	-2.2	-2.3	-1.8	-1.2	-1.8	-1.9	-2.3	-2.1
Deep venous thrombosis (DVT) (self-reported)	2.7	3.4	5.4	-2.0	-2.0	-1.8	-2.1	-1.8	-1.6	-1.7	-1.7	-2.0	-1.5	-2.3	-1.4	-1.7
Lung FVC	2.6	13.2	16.2	-3.9	-3.8	-4.0	-3.7	-3.5	-3.7	-4.0	-3.1	-3.5	-3.7	-3.5	-3.6	-3.1
Medication: Co-codamol	2.6	3.1	4.7	-1.6	-1.6	-1.7	-1.8	-1.7	-1.7	-2.0	-2.2	-1.3	-1.9	-1.8	-1.4	-1.8
Hypothyroidism/myxoedema (self-reported)	2.6	5.0	9.2	-1.9	-2.7	-3.0	-2.1	-2.1	-2.3	-2.4	-2.1	-1.2	-1.9	-2.2	-2.6	-2.1
Alcohol intake frequency.	2.6	6.1	15.1	-2.1	-1.7	-1.9	-1.3	-1.9	-2.9	-2.3	-1.6	-3.9	-2.0	-2.7	-3.1	-3.2
Pain all over the body in last month	2.5	2.7	3.6	-1.8	-1.5	-1.5	-1.8	-1.7	-1.6	-1.7	-1.9	-0.8	-1.7	-1.5	-1.6	-1.7
Average weekly beer plus cider intake	2.5	3.5	6.4	-1.9	-2.0	-2.1	-1.8	-1.9	-1.6	-2.5	-2.1	-1.3	-2.2	-1.9	-1.4	-1.4
Eye problems/disorders: Diabetes related eye disease	2.4	2.6	5.0	1.7	2.1	2.1	2.2	1.4	1.1	1.2	1.6	1.4	1.4	1.9	0.9	1.5
Tinnitus: Yes, but not now, but have in the past	2.4	2.5	4.3	1.4	1.7	1.5	1.9	1.7	1.5	1.5	1.7	2.1	1.3	1.4	1.4	1.3
Bilateral oophorectomy (both ovaries removed)	2.2	2.5	4.6	1.4	1.9	1.8	1.7	1.6	1.1	2.0	1.3	2.1	1.2	1.5	1.1	1.2
Blood clot in the leg (DVT)	2.1	2.7	4.6	-1.7	-2.0	-1.7	-2.0	-1.6	-1.3	-1.4	-1.5	-1.7	-1.4	-2.1	-1.1	-1.5
Ever had bowel cancer screening	2.1	2.4	4.0	-1.6	-1.5	-1.4	-1.8	-1.8	-1.7	-1.6	-1.8	-0.5	-2.0	-1.2	-1.5	-1.1
Hearing difficulty/problems with background noise	2.0	3.3	8.7	1.6	1.5	1.5	1.8	1.8	2.6	1.6	1.6	1.1	1.3	1.6	2.9	1.8
Exposure to tobacco smoke at home	2.0	2.2	4.7	1.5	1.1	1.1	2.0	1.7	1.6	0.9	2.2	1.2	1.2	1.3	1.3	1.6
Hayfever, allergic rhinitis or eczema	1.9	4.2	8.9	-2.2	-2.4	-2.3	-1.8	-2.1	-1.7	-3.0	-2.2	-1.3	-1.8	-1.7	-1.4	-2.1
Mouth/teeth dental problems: Bleeding gums	1.9	2.4	6.0	-1.2	-1.5	-1.7	-1.2	-1.2	-1.8	-0.9	-1.0	-2.2	-0.6	-1.3	-2.5	-2.0
Number of full brothers	1.9	2.4	4.8	-2.2	-1.4	-1.3	-1.8	-1.7	-1.4	-1.7	-1.6	-0.5	-1.3	-1.6	-1.4	-1.7
Heart disease (siblings)	1.9	2.3	4.5	-1.8	-1.8	-1.7	-1.4	-1.5	-1.0	-2.1	-1.8	-0.2	-1.7	-1.8	-0.2	-1.4
Intelligence (Savage-Jansen 2018)	1.8	5.4	7.9	-2.0	-2.2	-2.2	-2.5	-2.3	-2.5	-1.4	-2.5	-2.4	-2.0	-2.3	-2.7	-2.8
Hypothyroidism (self reported)	1.8	4.1	7.9	-1.6	-2.4	-2.8	-1.9	-1.9	-2.0	-2.2	-2.1	-0.7	-1.7	-2.1	-2.2	-1.9
Fluid intelligence score	1.8	3.7	7.0	-1.5	-2.0	-1.8	-1.9	-1.9	-1.7	-1.1	-1.8	-2.6	-1.9	-1.9	-1.8	-2.5
Mean time to correctly identify matches	1.8	3.5	5.1	1.9	1.4	1.4	2.2	1.9	2.0	1.9	2.0	1.6	1.4	2.0	2.1	2.2
Age started oral contraceptive pill	1.8	2.2	4.2	-1.0	-1.2	-1.5	-1.0	-1.2	-1.9	-1.2	-1.0	-1.7	-2.1	-1.3	-1.9	-1.9
Heel T-Score	1.7	13.4	28.0	3.8	3.6	3.3	3.6	3.6	2.8	2.8	5.3	1.9	3.1	5.3	2.9	3.9
Systolic Blood Pressure	1.7	8.3	14.3	-3.3	-1.9	-2.4	-3.4	-2.8	-2.2	-3.1	-3.6	-2.6	-2.5	-3.8	-2.0	-3.2
Body mass index (BMI)	1.7	7.2	8.9	-2.7	-2.6	-2.8	-2.6	-2.7	-2.7	-2.4	-2.9	-2.9	-2.6	-3.0	-2.3	-2.5
Family relationship satisfaction	1.7	2.1	4.6	1.5	0.7	0.7	1.1	1.4	1.9	1.3	1.1	1.9	1.2	1.5	1.8	2.1
Ever taken oral contraceptive pill	1.7	1.9	3.3	0.9	1.7	1.8	1.1	1.1	1.7	0.8	1.4	1.3	1.4	1.5	1.7	1.2
HbA1C	1.6	1.8	3.3	-1.6	-1.8	-1.4	-0.7	-1.1	-1.5	-1.4	-0.7	-1.4	-1.1	-1.4	-1.4	-1.4
Medication: Levothyroxine sodium	1.6	2.7	5.8	-1.1	-2.3	-2.4	-1.4	-1.5	-1.5	-1.8	-1.3	-1.3	-1.9	-1.4	-1.7	-1.1
Past tobacco smoking	1.6	2.9	6.9	-1.4	-1.1	-0.9	-1.4	-1.5	-2.0	-0.9	-1.0	-2.6	-1.7	-1.8	-2.0	-2.5
Happiness	1.6	1.9	3.2	-1.5	-1.2	-1.3	-1.7	-1.5	-1.6	-0.9	-1.3	-0.9	-1.3	-1.4	-1.8	-1.4
Long-standing illness, disability or infirmity	1.6	2.4	3.6	-1.3	-1.7	-1.6	-1.1	-1.4	-1.6	-1.8	-1.8	-1.9	-1.7	-1.3	-1.6	-1.1
Financial situation satisfaction	1.6	2.0	3.1	-1.6	-1.4	-1.5	-1.8	-1.4	-1.3	-1.7	-1.4	-0.0	-1.1	-1.6	-1.4	-1.4
Impedance of whole body	1.5	7.8	11.8	2.6	2.7	2.8	1.8	2.7	3.4	2.4	2.5	3.1	2.7	2.8	3.4	2.9
Ovarian Cancer	1.4	1.8	3.3	1.6	1.8	1.7	1.4	1.4	0.8	1.4	1.1	1.1	1.5	1.5	0.5	0.8
High blood pressure (mother)	1.4	1.9	4.2	-0.9	-1.2	-1.2	-1.5	-1.2	-1.2	-0.8	-1.5	-2.1	-0.8	-1.7	-1.4	-1.9
Standing height	1.4	13.6	29.3	4.3	3.1	3.4	3.8	3.6	3.1	5.4	1.7	3.9	3.9	4.2	2.5	3.6
Gout (self-reported)	1.4	2.0	3.3	-1.3	-1.1	-1.1	-1.5	-1.3	-1.5	-1.5	-1.6	-1.8	-0.8	-1.6	-1.8	-1.1
Ever depressed for a whole week	1.4	1.7	2.8	1.7	1.1	1.1	1.3	1.6	1.2	1.4	1.4	1.2	0.9	1.3	1.0	1.6
Bipolar Disorder or Schizophrenia	1.3	3.3	6.6	1.7	1.2	1.0	1.6	1.9	2.3	1.5	1.9	2.2	0.7	1.6	2.3	2.6
Reaction Time	1.3	2.4	4.4	1.5	1.1	1.1	1.7	1.6	1.9	1.3	1.8	1.3	1.4	1.5	2.1	1.6
Blood White Count	1.3	9.4	20.8	-2.9	-2.1	-2.9	-2.4	-2.8	-3.2	-2.5	-3.0	-3.4	-1.8	-3.9	-3.4	-4.6
Supplements: Glucosamine	1.3	1.7	3.2	1.2	1.7	1.7	1.5	1.3	0.5	1.8	1.4	0.5	1.0	1.2	0.4	1.5
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.1	5.2	-1.5	-1.5	-1.4	-1.4	-1.4	-1.0	-2.3	-1.7	-1.3	-1.3	-1.5	-1.1	-1.1
Depression (self-reported)	1.3	1.6	3.1	-1.5	-1.4	-1.3	-1.1	-1.2	-0.9	-1.8	-1.1	-0.9	-1.6	-1.4	-0.5	-1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.5	3.1	-1.3	-0.5	-0.6	-1.2	-1.3	-1.3	-1.3	-1.2	-1.7	-0.7	-1.1	-1.2	-1.8
Supplements: Vitamin C	1.3	1.6	3.9	1.2	1.9	1.5	1.1	1.2	0.9	0.9	1.1	2.0	0.7	1.2	0.7	1.2
Leg fat percentage (left)	1.3	4.5	6.8	-2.1	-2.0	-2.1	-2.4	-2.2	-1.8	-1.9	-2.4	-2.4	-2.1	-2.6	-1.4	-2.0
BMI	1.2	6.9	10.5	-2.5	-2.1	-2.5	-2.3	-2.4	-2.7	-2.5	-2.6	-3.1	-2.4	-3.2	-2.5	-3.0
Medication: Amlodipine	1.2	1.7	5.1	-1.0	-1.4	-1.4	-1.7	-1.1	-0.7	-1.2	-1.0	-2.3	-1.2	-1.7	-0.5	-0.8
Worry too long after embarrassment	1.2	2.0	3.1	-1.1	-1.3	-1.5	-1.7	-1.6	-1.5	-1.4	-1.8	-0.9	-1.5	-1.5	-1.4	-1.3
Number of children fathered	1.2	1.4	2.1	1.3	1.5	1.4	0.9	1.1	1.1	1.1	0.9	1.2	1.2	1.4	1.1	1.1
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	2.5	1.2	0.8	0.8	1.1	1.4	1.4	1.2	1.6	1.1	1.4	1.2	1.3	1.1
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	3.4	1.2	0.5	0.5	0.9	1.1	1.9	0.8	1.1	1.0	0.9	0.8	1.9	1.3
Miserableness	1.2	2.0	3.0	-1.4	-1.7	-1.7	-1.4	-1.4	-1.0	-1.4	-1.4	-1.7	-1.3	-1.6	-1.0	-1.2
Blood Eosinophil Count	1.1	8.6	18.7	-2.4	-2.6	-3.0	-3.3	-2.9	-3.0	-1.9	-2.8	-2.9	-1.5	-3.4	-3.0	-4.3
Height	1.1	21.3	47.1	5.5	3.8	4.1	4.7	4.4	3.6	6.9	2.1	5.7	5.1	5.1	2.5	4.4
Age when periods started (menarche)	1.1	2.6	6.5	-1.5	-1.3	-1.3	-1.1	-1.6	-1.5	-1.5	-1.9	-2.5	-1.1	-1.8	-1.5	-1.8
Hair/balding pattern: Pattern 2	1.1	1.4	3.8	1.2	1.3	1.2	1.6	1.2	0.6	0.9	1.2	0.7	2.0	1.4	-0.1	0.8
Allergy	1.1	2.5	6.0	1.8	2.0	1.7	1.3	1.6	1.0	2.5	1.7	0.9	1.3	1.5	0.6	1.7
Neuroticism score	1.1	2.4	3.6	-1.2	-1.7	-1.9	-1.6	-1.5	-1.4	-1.4	-1.7	-1.9	-1.4	-1.6	-1.5	-1.1
Number of live births	1.1	1.6	3.3	-1.2	-1.5	-1.5	-1.6	-1.2	-0.4	-1.4	-0.9	-0.7	-1.3	-1.8	-0.1	-1.4
Commuting to job workplace: Walk	1.1	1.2	2.2	1.3	1.1	1.2	1.2	1.5	1.1	1.1	0.7	1.3	0.8	1.0	0.7	0.7
Mineral and other dietary supplements	1.1	1.5	2.6	-1.4	-1.5	-1.3	-1.4	-1.4	-0.6	-1.6	-1.2	-1.3	-1.2	-1.0	-0.3	-0.9
Number of incorrect matches in round	1.0	1.6	4.2	1.2	1.1	1.0	0.9	1.2	1.4	0.7	1.3	2.0	0.8	1.1	1.6	1.7
Hair/balding pattern: Pattern 4	1.0	2.5	4.0	-2.0	-1.4	-1.6	-1.6	-1.8	-1.8	-1.1	-1.5	-1.9	-1.2	-1.5	-1.3	-1.6
Age at first live birth	1.0	1.9	4.4	1.5	1.1	1.2	1.3	1.4	1.3	1.2	1.4	1.1	0.9	1.4	1.4	2.1
Breast cancer (self-reported)	1.0	1.2	2.0	-1.3	-1.3	-1.3	-1.1	-1.2	-0.9	-1.4	-1.2	-1.3	-0.6	-1.0	-0.8	-0.5
Number of self-reported non-cancer illnesses	1.0	1.8	3.3	-1.4	-1.2	-1.1	-1.2	-1.1	-1.1	-1.5	-1.4	-1.7	-1.0	-1.8	-1.1	-1.4
Alcohol drinker status: Never	1.0	1.2	2.5	-0.9	-0.8	-1.1	-0.9	-0.9	-0.8	-1.6	-1.0	-1.5	-1.2	-1.4	-0.0	-1.4
Allergy or Eczema	0.9	2.5	7.2	-1.7	-2.0	-1.9	-1.2	-1.6	-1.2	-2.7	-1.7	-0.9	-1.1	-1.1	-1.1	-1.2
Chronotype (morning person)	0.9	2.1	3.8	-2.0	-0.9	-0.9	-1.3	-1.3	-1.2	-1.6	-1.0	-1.7	-1.8	-1.7	-1.0	-1.8
Stomach or abdominal pain in last month	0.9	1.1	3.2	0.8	0.9	1.1	0.7	1.0	1.3	0.7	0.9	1.8	1.0	0.9	1.3	0.9
Medication: Simvastatin	0.9	1.4	2.8	-1.7	-0.6	-0.7	-1.3	-1.3	-1.1	-1.4	-1.3	-1.3	-0.7	-1.2	-0.9	-1.1
Falls in the last year	0.9	1.2	1.9	1.2	0.9	0.8	0.8	1.1	1.1	1.1	1.0	1.2	1.4	1.0	1.0	1.2
Pulse wave peak to peak time	0.9	1.0	2.5	0.9	0.5	0.7	0.7	0.6	1.1	1.0	0.7	1.6	0.4	1.1	1.5	1.5
Age at last live birth	0.9	1.4	3.5	1.3	0.7	0.7	1.0	1.1	1.2	0.8	1.1	1.6	0.8	1.3	1.1	1.9
Hypertension (Self-reported)	0.9	2.6	5.7	-1.5	-1.5	-1.4	-2.2	-1.6	-0.6	-1.5	-2.4	-1.5	-1.9	-2.4	-0.2	-0.8
Friendships satisfaction	0.9	1.1	2.5	1.1	0.7	0.8	0.6	0.9	1.2	1.0	1.0	1.6	1.1	1.1	1.0	1.1
Supplements: Fish oil (including cod liver oil)	0.9	1.2	2.6	1.3	1.0	1.0	1.3	1.3	0.8	1.6	1.2	1.1	1.0	0.8	0.7	1.0
Major Depression (MDD)	0.8	1.0	1.7	1.3	1.2	1.0	1.0	1.3	0.9	1.1	1.1	0.7	0.5	0.8	1.3	0.6
Hearing difficulty/problems: Yes	0.8	1.2	2.6	1.2	0.9	0.7	1.4	1.3	1.4	1.0	0.7	-0.3	0.6	0.9	1.6	1.2
High blood pressure	0.8	2.1	5.1	-1.4	-1.3	-1.2	-2.0	-1.4	-0.4	-1.3	-2.3	-1.5	-1.7	-2.1	-0.1	-0.7
Sitting height	0.8	5.6	13.2	2.8	2.0	2.2	2.7	2.2	2.1	3.6	0.8	1.8	2.8	2.6	1.6	2.0
Forced expiratory volume in 1-second (FEV1)	0.8	2.6	4.2	-1.8	-1.5	-1.4	-1.7	-1.7	-2.0	-1.1	-1.9	-0.6	-1.2	-1.3	-2.1	-1.8
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	2.3	-0.6	-1.0	-1.0	-1.0	-0.9	-1.0	-1.2	-1.2	-0.4	-0.7	-0.8	-1.5	-0.8
Leg fat percentage (right)	0.8	2.8	4.5	-1.5	-1.5	-1.6	-1.9	-1.6	-1.3	-1.5	-2.0	-2.0	-1.7	-2.1	-0.9	-1.6
Eye problems/disorders: None of the above	0.8	0.9	3.2	0.9	0.4	0.3	1.2	0.9	1.1	1.0	1.1	-0.4	1.8	0.7	0.9	0.7
Eye problems/disorders: Glaucoma	0.8	1.0	1.7	1.1	1.1	1.2	1.0	1.1	0.8	1.3	1.2	1.0	1.0	0.7	0.6	0.2
Pain type(s) experienced in last month: Hip pain	0.8	1.0	2.7	0.9	0.7	0.8	1.0	1.0	1.2	0.8	0.8	0.9	0.6	1.0	1.6	1.3
Medication: Lisinopril	0.8	1.0	1.9	0.8	1.1	1.1	0.7	1.0	1.3	0.5	0.4	1.4	1.2	0.8	1.2	1.1
Commuting to job workplace: Cycle	0.8	0.9	1.5	-1.0	-0.9	-0.8	-1.0	-0.9	-1.2	-0.8	-1.2	-0.8	-0.6	-0.7	-1.1	-1.2
Lung FEV1/FVC ratio	0.7	3.6	6.7	-2.0	-1.7	-1.7	-1.9	-2.1	-2.5	-0.8	-1.0	-2.5	-1.2	-1.6	-2.6	-2.2
Ever used hormone-replacement therapy (HRT)	0.7	0.9	1.9	-1.0	-0.9	-0.7	-0.9	-0.9	-1.4	-1.0	-1.2	-0.5	-1.2	-0.5	-1.2	-0.6
Financial difficulties in last 2 years	0.7	0.9	1.9	-1.3	-0.8	-0.8	-1.1	-1.2	-0.7	-1.4	-1.2	-0.1	-0.9	-1.1	-0.5	-0.6
Mouth/teeth dental problems	0.7	1.1	3.8	0.8	0.7	1.0	1.0	0.9	1.3	1.3	0.7	1.1	0.4	0.7	1.9	1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.3	3.9	-1.6	-1.5	-1.5	-1.7	-1.6	-1.8	-1.3	-2.0	-0.2	-0.9	-1.3	-1.9	-1.6
Length of working week for main job	0.7	0.7	2.0	-1.1	-0.5	-0.5	-0.8	-1.0	-0.9	-0.9	-1.1	-0.3	-1.4	-0.9	-0.6	-0.6
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	3.2	-0.9	-0.8	-1.0	-0.9	-1.1	-1.4	-1.0	-1.0	-0.4	-1.0	-0.9	-1.3	-1.8
Exposure to tobacco smoke outside home	0.7	1.0	2.4	0.8	0.7	0.8	1.6	1.2	1.1	0.4	1.2	0.5	0.7	1.1	1.0	1.2
Comparative body size at age 10	0.7	1.8	6.3	-1.4	-1.2	-1.3	-1.3	-1.2	-2.0	-0.7	-1.0	-1.1	-0.7	-0.9	-2.5	-1.3
Comparative height size at age 10	0.7	4.1	12.5	2.4	1.2	1.4	2.0	1.8	1.8	3.5	1.5	1.0	2.0	2.3	1.6	2.5
High cholesterol (Self-reported)	0.7	1.2	2.3	-1.3	-0.4	-0.2	-1.2	-1.1	-1.2	-1.5	-1.2	-1.0	-0.4	-1.1	-1.2	-1.5
Fractured/broken bones in last 5 years	0.7	1.0	2.6	1.0	1.1	1.1	0.9	1.0	0.7	1.6	0.8	0.7	1.5	1.0	0.1	0.4
Leg fat mass (left)	0.7	2.6	5.2	-1.5	-1.7	-1.7	-1.7	-1.6	-1.5	-1.0	-2.3	-1.8	-1.4	-1.9	-1.2	-1.4
Impedance of leg (right)	0.6	2.8	5.5	1.7	1.5	1.7	1.2	1.7	2.3	1.3	1.5	1.5	1.7	1.5	2.3	1.6
Medication: Atenolol	0.6	0.7	1.2	-1.0	-0.2	-0.4	-1.1	-1.0	-1.0	-0.7	-1.0	-0.7	-1.1	-0.9	-0.8	-0.4
Had other major operations	0.6	0.8	2.0	0.8	0.4	0.5	0.5	0.8	1.2	1.0	0.6	0.9	0.7	0.7	1.4	1.2
Alcohol intake versus 10 years previously	0.6	0.9	2.1	1.2	1.0	1.1	1.4	1.0	0.9	0.6	1.1	0.2	0.5	0.7	1.2	0.5
Arm fat-free mass (right)	0.6	2.9	7.1	-1.1	-1.9	-1.8	-0.7	-1.5	-2.3	-0.3	-2.2	-1.9	-1.1	-1.5	-2.7	-1.8
Suffer from ‘nerves’	0.6	1.0	1.4	-0.8	-1.0	-1.2	-1.1	-1.0	-0.8	-0.9	-1.1	-0.9	-1.1	-1.1	-0.9	-1.2
Leg pain on walking	0.6	0.7	2.7	-0.9	-0.6	-0.6	-0.7	-0.9	-0.6	-1.6	-0.7	-0.8	-0.9	-0.9	-0.4	-0.5
Eye problems/disorders: Cataract	0.6	0.7	2.8	-0.6	-0.4	-0.4	-1.2	-0.7	-0.6	-0.7	-1.1	0.9	-1.7	-0.8	-0.1	-0.7
Osteoporosis (self-reported)	0.6	0.8	2.1	-0.9	-0.7	-0.6	-1.0	-0.8	-0.7	-1.4	-0.8	-0.4	-0.9	-0.9	-0.9	-1.0
Wears glasses or contact lenses	0.6	0.7	2.2	0.8	0.8	0.8	0.7	0.8	0.7	0.8	0.9	1.5	0.7	0.8	0.5	0.5
Vascular/heart problems diagnosed by doctor	0.6	1.6	4.2	1.2	1.1	0.9	1.8	1.3	0.4	1.2	2.0	1.0	1.5	1.8	0.1	0.4
Primary Biliary Cirrhosis	0.5	0.7	1.8	-0.7	-0.9	-0.7	-0.9	-0.8	-0.5	-1.1	-1.3	0.9	-0.7	-0.8	-0.4	-0.3
Ulcerative Colitis	0.5	0.7	1.8	0.7	0.5	0.6	0.7	0.8	1.2	0.6	1.3	0.5	0.7	0.6	1.3	0.8
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.5	-0.7	-0.9	-1.0	-0.7	-0.7	-0.2	-1.1	-0.7	-1.2	-1.1	-1.0	0.1	-0.0
Ever had hysterectomy (womb removed)	0.5	0.6	1.8	-0.9	-0.7	-0.7	-0.7	-0.6	-0.7	-0.5	-0.5	-0.7	-1.3	-0.9	-0.5	-0.5
Systolic blood pressure, automated reading	0.5	1.3	3.1	-1.1	-0.6	-0.8	-1.6	-1.1	-0.6	-1.0	-1.7	-1.3	-0.9	-1.7	-0.4	-1.1
Hand grip strength (right)	0.5	1.3	2.6	1.2	1.2	1.1	1.6	1.2	0.7	1.2	1.1	0.9	1.1	1.6	0.7	1.0
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	1.3	-1.0	-0.8	-1.1	-0.8	-0.9	-0.7	-0.8	-0.6	-1.0	-0.7	-1.2	-0.5	-0.5
Hip circumference	0.5	2.1	5.2	-1.3	-1.5	-1.7	-1.6	-1.4	-1.5	-0.5	-2.3	-1.0	-1.3	-1.5	-1.5	-0.9
Pulse wave Arterial Stiffness index	0.5	0.5	1.6	-0.5	-0.2	-0.4	-0.3	-0.3	-0.9	-0.5	-0.6	-1.2	-0.1	-0.7	-1.3	-1.2
Emphysema/chronic bronchitis	0.5	0.6	1.2	0.7	0.4	0.4	0.8	0.9	0.8	0.6	0.7	0.3	1.1	0.7	0.7	1.1
Medication: Omeprazole	0.5	0.6	1.4	-1.0	-0.3	-0.3	-0.9	-0.8	-0.7	-0.9	-1.1	-0.5	-0.6	-0.8	-0.4	-1.2
Illnesses of siblings: Diabetes	0.5	0.7	1.7	-0.8	-0.8	-1.0	-0.2	-0.8	-1.1	-0.9	-0.3	-1.3	-0.2	-0.5	-1.1	-0.4
Smoking status: Previous	0.5	0.7	2.3	0.5	0.2	0.2	0.5	0.5	1.0	0.3	0.1	1.5	0.6	1.0	1.0	1.5
Mood swings	0.5	1.0	3.0	-0.8	-1.1	-1.1	-0.9	-1.0	-0.9	-1.0	-0.9	-1.7	-0.3	-0.8	-1.1	-0.4
Illnesses of father: None of the above (group 1)	0.5	0.6	1.1	-0.5	-1.0	-0.9	-0.8	-0.7	-0.8	-0.6	-0.4	-0.6	-0.8	-0.9	-1.0	-0.8
Guilty feelings	0.5	0.8	1.4	-0.8	-0.9	-1.0	-1.1	-1.0	-0.5	-0.8	-1.2	-1.0	-0.8	-1.0	-0.5	-0.3
Number of operations (self-reported)	0.5	0.7	1.3	1.0	1.0	0.8	0.9	1.1	0.8	1.0	0.6	0.6	0.9	0.8	0.7	0.8
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	2.2	-0.9	-0.0	-0.0	-0.7	-0.6	-0.8	-0.7	-1.0	-0.4	-0.7	-0.9	-0.4	-1.5
Alcohol drinker status: Previous	0.5	0.5	1.9	-0.7	-0.3	-0.5	-0.5	-0.6	-1.1	-0.4	-0.5	-0.6	-0.8	-0.8	-1.4	-0.7
Coronary Artery Disease (CAD)	0.4	0.5	1.4	0.7	1.0	0.8	0.8	0.8	0.5	0.6	0.4	0.7	1.2	0.6	0.3	0.5
Mean Putamen Volume	0.4	0.4	1.3	-0.2	-1.0	-1.1	-0.5	-0.6	-0.7	-0.6	-0.7	-0.4	-0.8	-0.4	-0.7	-0.2
Rheumatoid Arthritis	0.4	0.5	2.0	-0.7	-0.6	-0.6	-0.6	-0.6	-0.6	-0.7	-0.9	-0.3	-1.4	-0.9	-0.3	-0.8
Triglycerides	0.4	0.6	2.4	-0.9	-0.4	-0.7	-0.4	-0.6	-0.5	-0.9	-0.3	-1.6	-0.7	-1.2	-0.1	-0.9
Blood Platelet Count	0.4	5.1	22.3	-1.5	-0.5	-0.4	-0.3	-1.5	-3.0	-1.8	-0.9	-4.7	-1.1	-1.2	-2.9	-3.8
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.6	-1.0	-0.7	-0.6	-0.4	-1.1	-0.9	-1.2	-0.9	-0.8	-0.0	-0.5	-0.7	-1.2
Number of treatments/medications taken	0.4	0.6	2.4	-0.9	-0.4	-0.6	-0.8	-0.6	-0.8	-1.5	-0.8	-0.7	-0.8	-0.7	-0.7	-0.3
Chronic bronchitis/emphysema (father)	0.4	0.5	1.1	0.4	0.5	0.5	0.8	0.5	1.0	0.3	0.4	1.0	0.8	0.7	0.8	0.9
Diabetes (self-reported)	0.4	0.6	1.2	-0.9	-0.5	-0.4	-0.6	-1.0	-0.9	-1.1	-1.0	-0.5	0.1	-0.5	-0.8	-0.8
Worrier / anxious feelings	0.4	0.8	1.3	1.1	0.9	0.8	0.5	1.0	0.8	1.0	1.1	1.1	0.8	1.0	0.5	1.2
Mouth/teeth dental problems: Dentures	0.4	0.8	2.1	-0.9	-0.7	-0.9	-0.8	-0.9	-0.8	-1.4	-0.6	-0.4	-0.9	-1.0	-1.0	-0.6
Medication: Cholesterol lowering	0.4	0.6	1.3	0.3	1.0	1.1	0.8	0.7	0.7	0.5	0.7	0.2	0.9	0.7	0.8	0.7
Birth weight of first child	0.4	0.7	1.6	-0.3	-0.8	-0.7	-0.2	-0.7	-1.1	-0.5	-1.3	-0.5	-0.9	-0.8	-1.3	-1.1
Pulse wave reflection index	0.4	0.5	1.4	-0.7	-0.2	-0.4	-0.8	-0.5	-0.6	-0.7	-0.6	-0.2	-0.3	-1.0	-0.9	-1.2
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	3.0	0.3	0.2	0.2	0.1	0.3	0.9	-0.0	0.2	1.2	-0.1	-0.5	1.7	0.3
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.7	0.7	0.5	0.6	0.6	0.7	0.6	0.2	0.7	0.3	1.3	0.8	0.5	0.8
Leg fat mass (right)	0.4	1.7	3.7	-1.1	-1.3	-1.3	-1.3	-1.2	-1.2	-0.7	-1.9	-1.6	-1.1	-1.6	-1.0	-1.2
Arm predicted mass (right)	0.4	2.2	5.2	-0.9	-1.7	-1.6	-0.5	-1.3	-1.9	-0.1	-1.9	-1.7	-0.9	-1.3	-2.3	-1.6
Had major operations	0.4	0.4	1.5	-0.5	-0.8	-0.7	-0.2	-0.3	-0.5	-0.6	-0.4	-1.2	-0.3	-0.8	-0.8	-0.5
Loneliness, isolation	0.4	0.6	1.5	1.0	-0.1	-0.2	0.6	0.7	1.2	1.0	0.7	0.0	0.7	0.3	1.1	0.8
Diabetes diagnosed by doctor	0.4	0.7	1.3	-1.0	-0.6	-0.5	-0.4	-1.0	-1.0	-1.2	-0.9	-1.0	0.2	-0.5	-0.9	-1.1
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	1.3	0.8	1.1	1.2	0.7	0.7	0.3	0.7	1.0	0.4	0.9	1.1	0.1	0.8
Medication: Atorvastatin	0.4	0.5	1.4	0.7	0.6	0.8	0.6	0.6	0.5	0.3	0.6	1.2	0.9	0.6	0.8	0.5
Type 2 Diabetes (T2D) (2012)	0.3	0.3	1.4	-0.2	-0.3	-0.4	-0.1	-0.4	-1.1	-1.0	0.0	-0.2	-0.3	-0.0	-1.2	-0.1
Tanning	0.3	3.6	6.5	1.5	1.9	1.7	1.7	1.9	2.0	1.9	2.0	0.9	2.3	2.6	1.6	2.1
Supplements: Zinc	0.3	0.4	0.9	0.3	0.7	0.5	0.7	0.6	0.4	0.5	0.4	0.6	0.9	0.8	0.2	1.0
Townsend deprivation index at recruitment	0.3	0.5	0.9	0.4	0.9	0.8	0.6	0.6	0.7	0.1	0.8	0.9	0.8	0.2	0.8	0.7
Had menopause	0.3	0.4	1.2	-0.4	-0.6	-0.5	-0.6	-0.6	-1.0	-0.4	-0.2	0.0	-1.1	-0.5	-1.1	-0.5
Qualifications: None of the above	0.3	0.7	1.8	-0.7	-1.0	-0.9	-0.5	-0.6	-0.0	-1.4	-0.7	-0.5	-1.2	-1.2	0.2	-0.2
Heart attack	0.3	0.4	2.6	0.0	0.1	0.3	0.3	0.2	0.7	0.0	0.5	1.6	0.3	0.3	0.8	1.0
Medication: Ramipril	0.3	0.4	1.0	-0.7	-0.5	-0.2	-0.7	-0.6	-0.2	-0.9	-1.0	-0.5	-0.8	-0.5	-0.1	-0.0
Medication: Lansoprazole	0.3	0.3	0.9	-0.6	-0.3	-0.3	-0.6	-0.5	-0.6	-0.7	-0.2	-0.9	-0.2	-0.6	-0.7	-0.7
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	1.2	0.6	0.7	0.7	0.3	0.5	-0.3	0.9	0.5	1.1	0.6	0.7	-0.8	-0.2
Birth weight	0.3	0.7	2.4	-0.5	-1.0	-1.0	-0.6	-0.7	-1.0	-0.4	-1.2	-0.6	-0.3	-0.6	-1.5	-0.7
Heart disease (mother)	0.3	0.3	0.9	-0.6	-0.3	-0.4	-0.4	-0.5	-0.2	-0.9	-0.8	-0.5	-0.9	-0.6	0.1	-0.0
Pulse rate, automated reading	0.3	1.0	5.1	-0.5	-1.2	-0.9	-0.4	-0.8	-0.8	-0.0	-1.1	-2.3	-0.3	-1.1	-0.8	-0.8
Arm fat-free mass (left)	0.3	1.6	3.8	-0.7	-1.5	-1.4	-0.4	-1.1	-1.7	0.1	-1.9	-1.3	-0.7	-1.0	-1.9	-1.2
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.7	-0.2	-0.7	-0.6	-0.7	-0.4	-0.4	-0.8	-0.8	-0.3	-0.2	-0.3	-0.8	0.0
Pack years of smoking	0.3	0.4	1.1	-0.6	-0.5	-0.5	-1.0	-0.7	0.1	-0.7	-0.5	-0.4	-0.8	-1.0	0.2	-0.4
Arm predicted mass (left)	0.3	1.3	3.3	-0.5	-1.4	-1.3	-0.3	-1.0	-1.5	0.3	-1.8	-1.2	-0.5	-0.8	-1.8	-1.0
Worry (Nagel 2018)	0.2	0.4	1.0	-0.3	-0.5	-0.8	-0.9	-0.5	-0.8	-0.7	-0.8	-0.1	-0.6	-0.5	-1.0	-0.3
Alzheimer’s Disease (in mother)	0.2	0.3	0.8	0.4	0.3	0.3	0.2	0.4	0.5	0.1	0.5	0.7	-0.6	0.5	0.8	0.9
Alzheimer’s Disease (including proxy)	0.2	0.3	0.5	0.7	0.3	0.5	0.4	0.5	0.4	0.2	0.6	0.6	-0.6	0.5	0.7	0.5
Age at First Birth	0.2	0.3	1.1	0.1	-0.0	0.2	0.2	0.3	0.9	0.4	0.5	0.8	0.3	0.8	0.8	1.1
HDL Cholesterol	0.2	0.3	0.7	-0.2	-0.4	-0.2	-0.8	-0.3	-0.3	-0.3	-0.7	0.7	-0.7	-0.3	-0.7	-0.3
LDL Cholesterol	0.2	0.3	0.7	-0.8	-0.6	-0.7	-0.4	-0.6	-0.4	-0.7	-0.5	-0.3	-0.4	-0.6	-0.1	-0.9
Lupus	0.2	0.3	1.8	-0.3	-0.7	-0.6	-0.3	-0.1	0.0	-0.7	-1.4	0.0	-0.4	-0.4	0.1	-0.3
Medication for hormone replacement therapy	0.2	0.2	1.2	0.1	-0.0	0.1	0.0	0.2	0.4	0.1	-0.1	0.6	-0.2	0.7	0.5	1.1
Pack years adult smoking proportion	0.2	0.3	0.9	-0.5	-0.5	-0.5	-0.9	-0.5	0.3	-0.5	-0.4	-0.3	-0.6	-1.0	0.5	-0.3
Qualifications: CSEs or equivalent	0.2	0.2	1.1	-0.5	0.1	-0.1	-0.1	-0.0	-0.3	-1.1	0.1	-0.0	0.2	-0.4	-0.8	-0.7
Multivitamins +/- minerals	0.2	0.2	0.8	-0.3	-0.4	-0.5	-0.2	-0.3	-0.6	-0.3	-0.9	-0.1	0.1	-0.4	-0.8	-0.6
Impedance of leg (left)	0.2	0.8	2.1	0.8	0.7	0.9	0.4	0.8	1.4	0.5	0.6	0.9	1.0	0.6	1.5	0.8
Forced vital capacity (FVC)	0.2	0.7	2.0	-0.9	-0.8	-0.6	-0.8	-0.8	-1.0	-0.5	-1.4	0.3	-0.4	-0.4	-1.2	-0.8
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	1.9	-0.2	-0.2	-0.2	0.6	0.1	-0.2	-0.3	0.3	-1.4	0.4	0.3	-0.3	-0.2
Weight	0.2	0.9	3.7	-0.6	-0.9	-1.0	-0.7	-0.9	-1.1	0.3	-1.9	-0.9	-0.6	-0.8	-1.1	-0.7
Time employed in main current job	0.2	0.2	0.9	0.2	-0.2	-0.2	0.5	0.1	-0.5	-0.1	0.1	-0.9	-0.4	-0.0	-0.9	-0.0
Pulse rate	0.2	0.4	3.0	-0.3	-0.3	-0.2	-0.2	-0.4	-0.8	0.3	-0.1	-1.7	-0.0	-0.3	-1.1	0.1
Asthma	0.2	0.5	0.9	-0.8	-0.8	-0.8	-0.4	-0.7	-0.6	-1.0	-0.8	0.1	-0.8	-0.7	-0.2	-0.9
Peak expiratory flow (PEF)	0.2	0.5	1.1	-1.0	-0.8	-0.8	-0.8	-0.8	-0.5	-0.6	-1.0	0.4	-0.2	-0.6	-0.4	-1.0
Ever highly irritable/argumentative for 2 days	0.2	0.3	1.3	-0.6	-0.6	-0.7	-0.4	-0.5	-0.3	-1.1	-0.5	-0.3	-0.1	-0.1	-0.2	0.0
Medication: Paracetamol	0.2	0.4	1.4	-0.6	-0.2	-0.6	-0.4	-0.5	-0.8	-1.2	-0.2	-0.3	-1.0	-0.7	-0.6	-0.6
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.9	-0.6	-0.4	-0.1	-0.0	-0.3	0.4	-1.0	-0.2	-0.1	-0.2	0.3	0.7	0.8
Forced vital capacity (FVC), Best measure	0.2	0.7	2.2	-0.8	-0.8	-0.7	-0.9	-0.8	-1.1	-0.7	-1.5	0.5	-0.5	-0.5	-1.1	-0.6
Body fat percentage	0.2	0.8	2.2	-0.8	-0.7	-0.8	-1.4	-0.8	-0.5	-0.5	-1.5	-0.9	-0.7	-1.1	-0.1	-0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	1.1	-0.1	-0.9	-0.8	-0.1	-0.1	0.3	-1.0	-0.3	-0.2	-0.1	-0.4	0.5	0.3
Wheeze or whistling in the chest in last year	0.2	0.3	1.7	0.4	-0.0	-0.1	0.4	0.5	0.5	0.5	-0.0	1.3	-0.2	0.2	0.6	0.8
Medication: Blood pressure	0.2	0.3	2.1	0.1	-0.3	-0.2	-0.2	0.2	0.7	0.2	0.0	-0.7	-0.2	-0.2	0.6	1.5
Medication: Ibuprofen	0.2	0.2	0.6	0.2	0.7	0.4	0.3	0.2	0.1	0.5	0.5	-0.8	0.3	0.7	0.0	0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	1.0	-0.5	-0.4	-0.4	-0.2	-0.4	-0.4	-0.5	-0.1	-0.2	0.0	-0.5	-0.5	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	2.4	0.6	0.1	0.1	0.3	0.3	0.3	0.9	-0.7	1.6	0.6	0.3	0.5	0.2
Arm fat percentage (left)	0.2	0.6	1.9	-0.7	-0.6	-0.8	-1.4	-0.7	-0.4	-0.5	-1.3	-0.6	-0.9	-0.9	-0.0	-0.4
Handedness (chirality/laterality): Left-handed	0.2	0.3	1.0	-0.7	-0.2	-0.3	-0.4	-0.5	-0.3	-1.0	-0.7	-0.6	-0.3	-0.4	-0.2	-0.7
Qualifications: nursing, teaching	0.2	0.3	0.9	0.5	0.6	0.3	0.4	0.3	-0.5	0.9	0.1	0.7	0.5	0.7	-1.0	0.1
Asthma (self-reported)	0.2	0.4	0.9	-0.7	-0.7	-0.6	-0.3	-0.6	-0.6	-0.8	-0.7	0.1	-0.7	-0.6	-0.2	-0.9
Osteoarthritis (self-reported)	0.2	0.2	0.6	0.5	0.5	0.5	0.5	0.4	0.5	0.5	0.1	0.1	0.7	0.1	0.4	0.7
Medication: Aspirin	0.2	0.2	1.0	0.1	0.4	0.4	0.2	0.1	0.5	-0.3	0.3	0.7	-0.0	0.0	0.7	1.0
Medication: Gliclazide	0.2	0.2	1.7	-0.3	-0.3	-0.2	0.1	-0.3	-0.2	-1.3	-0.3	-0.2	-0.6	-0.3	-0.3	-0.2
Arm fat mass (left)	0.2	0.9	2.8	-0.8	-1.0	-1.1	-1.2	-0.9	-0.8	-0.4	-1.7	-0.9	-0.8	-1.0	-0.7	-0.7
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.4	0.5	0.6	0.5	0.6	0.4	-0.1	0.4	0.5	0.2	-0.2	0.7	-0.1	0.6
Medication: Paracetamol	0.2	0.4	1.1	-0.6	-0.1	-0.4	-0.3	-0.4	-0.8	-0.9	-0.3	-0.1	-1.0	-0.8	-0.5	-0.7
Risk taking	0.2	0.3	1.6	-0.5	-0.1	-0.1	-0.4	-0.2	0.5	-0.4	-0.5	1.3	-0.3	-0.1	0.8	-0.1
Unable to work because of sickness or disability	0.2	0.2	0.8	-0.6	-0.8	-0.8	-0.2	-0.3	0.3	-0.9	0.0	0.1	0.4	-0.3	0.1	0.1
Supplements: Calcium	0.2	0.2	0.9	-0.2	-0.2	-0.1	-0.1	-0.2	-0.3	-0.8	-0.2	0.5	-0.1	-0.2	-0.5	-0.9
Heart attack/myocardial infarction (self-reported)	0.2	0.3	2.2	-0.2	-0.0	0.1	0.1	0.0	0.5	-0.3	0.3	1.5	-0.0	0.1	0.6	0.8
Bipolar Disorder (2018)	0.1	0.1	0.7	0.0	0.3	-0.0	-0.2	-0.0	0.0	-0.4	-0.1	0.7	-0.8	-0.3	0.1	-0.1
Depressed Affect (Nagel 2018)	0.1	0.1	0.3	0.6	0.1	-0.0	0.5	0.4	0.5	0.3	0.3	-0.3	0.5	0.1	0.4	0.5
Depression (Nagel 2018)	0.1	0.2	0.5	-0.2	-0.5	-0.7	-0.1	-0.1	0.3	-0.7	-0.3	-0.7	-0.5	-0.7	0.4	0.2
Alzheimer’s Disease (in father)	0.1	0.1	0.3	0.4	0.4	0.3	0.4	0.3	0.1	0.5	0.4	-0.2	-0.0	0.6	0.1	0.3
Crohns Disease (2017)	0.1	0.1	0.9	-0.1	0.1	0.0	0.3	-0.1	0.7	-0.3	0.4	-0.0	-0.1	-0.0	1.0	0.2
Irritable Bowel Disease (IBD)	0.1	0.1	0.6	-0.2	-0.3	-0.4	0.0	-0.1	0.6	-0.3	0.4	-0.2	-0.3	-0.2	0.8	0.2
Fasting Glucose	0.1	0.1	0.6	-0.7	-0.2	-0.3	0.1	-0.1	0.1	0.1	-0.4	-0.8	0.5	0.0	0.2	-0.4
Neuroticism (2016)	0.1	0.1	0.5	-0.2	-0.3	-0.3	-0.2	0.0	0.1	-0.2	-0.4	0.4	-0.7	-0.3	0.2	-0.1
Cardiovascular Disease	0.1	0.4	1.5	-0.4	0.4	0.3	-0.6	-0.2	0.4	-0.6	-1.2	-0.6	-0.2	-1.2	0.6	-0.3
Respiratory disease	0.1	0.3	1.1	0.4	0.5	0.6	1.0	0.5	0.3	0.1	0.4	0.6	0.3	0.4	0.6	0.6
Neuroticism	0.1	0.3	0.7	0.0	-0.4	-0.7	-0.5	-0.4	-0.4	-0.4	-0.9	-0.9	-0.4	-0.4	-0.6	-0.0
Sensitivity / hurt feelings	0.1	0.1	0.4	-0.3	-0.3	-0.2	-0.5	-0.2	0.1	-0.5	-0.5	0.2	-0.1	-0.6	0.2	-0.2
Relative age of first facial hair	0.1	0.2	0.6	0.1	-0.4	-0.4	-0.8	-0.2	-0.3	-0.4	-0.3	0.4	0.0	-0.3	-0.6	-0.3
Vitamin and mineral supplements	0.1	0.2	0.8	-0.1	-0.2	0.0	-0.1	-0.2	0.5	-0.0	0.4	-0.9	-0.4	-0.1	0.9	0.3
Medication: Metformin	0.1	0.2	0.5	-0.4	-0.1	0.0	0.1	-0.4	-0.4	-0.5	-0.2	-0.0	0.7	-0.1	-0.4	-0.7
Severe depression (siblings)	0.1	0.1	0.4	-0.3	-0.1	-0.0	-0.2	-0.3	-0.6	-0.3	-0.3	-0.2	-0.2	-0.1	-0.5	-0.4
Leg fat-free mass (left)	0.1	0.3	1.4	0.4	-0.1	-0.1	0.4	0.0	-0.6	1.2	-1.0	-0.3	0.3	0.3	-0.8	0.1
Trunk fat percentage	0.1	0.3	1.4	-0.4	-0.3	-0.4	-1.0	-0.3	0.0	-0.0	-1.2	-0.5	-0.3	-0.5	0.3	0.0
Fed-up feelings	0.1	0.1	0.5	0.1	0.0	-0.0	-0.0	-0.2	-0.3	-0.4	-0.2	-0.7	0.7	-0.2	-0.5	-0.4
Relative age voice broke	0.1	0.1	0.4	0.2	0.2	0.2	-0.2	0.2	0.0	0.5	-0.4	0.6	0.4	0.3	-0.2	0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	1.4	0.3	0.3	0.0	0.4	0.1	-0.1	-0.5	1.0	0.2	-0.2	1.2	-0.1	0.9
Serious illness, injury or assault to yourself	0.1	0.1	0.3	0.0	0.4	0.4	0.4	0.2	-0.1	0.4	0.2	0.4	0.6	0.2	-0.3	-0.1
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.3	-0.0	-0.2	-0.2	-0.4	-0.1	-0.0	0.2	0.4	-0.5	-0.2	-0.2	0.0	0.2
Leg predicted mass (left)	0.1	0.3	1.4	0.4	-0.1	-0.1	0.3	0.0	-0.6	1.2	-1.0	-0.3	0.3	0.2	-0.8	0.1
Waist circumference	0.1	0.2	1.4	-0.2	-0.5	-0.5	-0.0	-0.3	-0.4	-0.1	-0.9	-1.2	-0.3	-0.3	-0.1	0.0
Nervous feelings	0.1	0.1	0.4	0.1	-0.3	-0.5	-0.1	0.1	-0.1	-0.4	0.2	0.7	-0.1	-0.3	-0.4	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.7	0.1	0.3	-0.0	0.2	-0.0	-0.4	-0.4	0.8	-0.9	-0.1	0.9	-0.3	0.5
Arm fat percentage (right)	0.1	0.4	1.4	-0.5	-0.4	-0.6	-1.1	-0.5	-0.2	-0.2	-1.2	-0.5	-0.6	-0.6	0.2	-0.0
Trunk fat-free mass	0.1	0.5	2.3	0.4	-0.5	-0.5	0.7	-0.0	-0.7	1.5	-1.1	-0.3	0.3	0.2	-1.1	-0.0
Hair/balding pattern: Pattern 3	0.1	0.1	0.3	-0.1	0.1	0.1	0.2	-0.0	0.2	-0.5	0.4	-0.4	-0.6	-0.5	0.4	-0.2
Qualifications: A levels/AS levels or equivalent	0.1	0.2	1.4	0.2	-0.4	-0.1	-0.3	-0.3	-0.8	0.0	-0.3	0.1	-0.4	0.2	-1.2	-0.1
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.2	1.2	-0.5	0.1	-0.2	-0.2	-0.4	-0.4	-0.4	-0.1	-1.1	-0.2	0.3	-0.4	0.3
Prospective memory result	0.1	0.1	0.9	-0.3	-0.4	-0.3	-0.2	-0.2	0.2	-1.0	0.0	-0.1	0.2	-0.4	0.3	-0.2
Illnesses of mother	0.1	0.1	0.5	0.2	0.0	0.1	0.0	0.1	-0.1	0.6	0.2	0.7	0.4	0.4	-0.4	-0.1
Arm fat mass (right)	0.1	0.6	2.2	-0.6	-0.8	-0.9	-0.9	-0.7	-0.7	-0.1	-1.5	-0.8	-0.7	-0.8	-0.4	-0.4
Trunk predicted mass	0.1	0.5	2.6	0.5	-0.5	-0.4	0.8	0.0	-0.7	1.6	-1.0	-0.2	0.4	0.3	-1.0	0.0
Breastfed as a baby	0.1	0.2	0.6	0.3	0.5	0.7	0.4	0.5	0.1	0.6	0.2	-0.0	0.2	0.4	0.0	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.5	-0.2	-0.3	-0.4	-0.5	-0.3	-0.5	-0.5	-0.7	0.2	-0.4	-0.5	-0.6	-0.4
Headache pain in last month	0.1	0.2	1.1	-0.3	0.1	0.1	0.0	-0.2	-0.2	-1.1	-0.1	-0.8	-0.2	0.2	-0.0	-0.0
Glaucoma (self-reported)	0.1	0.1	0.4	-0.1	-0.3	-0.2	-0.3	-0.1	-0.5	-0.0	-0.2	0.3	-0.5	-0.4	-0.7	-0.6
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.8	0.1	0.1	0.2	0.1	0.2	-0.1	-0.0	-0.0	0.1	0.9	0.1	-0.2	-0.8
Health satisfaction	0.1	0.1	0.7	0.1	-0.1	-0.3	0.1	0.2	0.5	-0.3	-0.0	0.1	0.5	0.2	0.2	0.9
Shortness of breath walking on level ground	0.1	0.2	0.8	-0.5	-0.4	-0.3	-0.4	-0.4	-0.1	-0.9	-0.3	-0.2	-0.2	-0.2	-0.2	0.5
Qualifications: College or University degree	0.1	0.4	2.0	0.5	0.3	0.5	-0.1	0.2	0.3	1.4	0.3	1.0	0.5	0.5	0.0	0.5
Medication for pain relief, constipation, heartburn	0.1	0.1	0.8	0.4	-0.2	0.1	-0.1	0.3	0.2	0.9	-0.0	0.6	0.2	0.1	0.1	-0.3
Neck or shoulder pain in last month	0.1	0.2	1.3	-0.0	-0.1	-0.1	0.1	0.2	0.8	-0.2	-0.1	0.5	-0.2	-0.1	1.1	0.4
Angina (self-reported)	0.1	0.1	0.5	-0.1	-0.1	-0.2	-0.1	0.1	0.4	-0.2	0.3	0.7	0.1	0.2	0.5	0.4
Migraine (self-reported)	0.1	0.1	1.0	0.1	0.1	-0.1	0.1	0.1	0.0	-0.3	0.2	-1.0	-0.4	0.1	0.2	0.1
Medication: Seretide 50 evohaler	0.1	0.1	0.3	0.2	-0.5	-0.6	0.2	0.1	-0.4	-0.3	-0.2	-0.5	0.1	0.0	-0.5	0.3
Whole body fat mass	0.1	0.4	2.0	-0.5	-0.6	-0.7	-0.8	-0.5	-0.5	0.1	-1.4	-0.8	-0.4	-0.7	-0.4	-0.3
Number of full sisters	0.1	0.1	0.5	-0.2	0.3	0.2	0.2	-0.1	-0.1	-0.5	-0.2	0.0	-0.7	-0.3	0.4	0.4
Overall health rating	0.1	0.1	0.6	-0.2	-0.6	-0.4	0.1	-0.0	0.4	-0.7	-0.3	0.0	0.0	-0.0	0.3	0.3
Chest pain or discomfort	0.1	0.1	0.5	-0.2	-0.2	-0.2	-0.1	-0.2	-0.2	-0.5	-0.5	0.3	-0.7	-0.2	0.0	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.5	0.1	0.7	0.4	0.4	0.3	-0.0	-0.1	-0.2	-0.3	0.5	0.3	-0.1	-0.1
Medication: Aspirin	0.1	0.1	0.5	-0.5	-0.1	-0.1	-0.3	-0.5	-0.1	-0.7	-0.3	-0.2	-0.3	-0.5	0.1	0.3
Knee pain experienced in last month	0.1	0.1	0.3	-0.2	-0.0	-0.2	-0.1	-0.0	0.3	-0.3	-0.3	-0.1	0.2	-0.1	0.5	0.6
Whole body fat-free mass	0.1	0.5	1.6	0.2	-0.6	-0.5	0.4	-0.2	-0.9	1.2	-1.3	-0.6	0.2	-0.0	-1.3	-0.3
Leg fat-free mass (right)	0.1	0.5	1.8	-0.0	-0.5	-0.4	0.0	-0.4	-1.0	0.9	-1.3	-0.5	0.0	-0.1	-1.2	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.2	0.3	0.1	0.2	0.4	0.2	0.1	-0.4	-0.1	-0.4	0.1	0.2	-0.0	0.3
Whole body water mass	0.1	0.5	1.5	0.2	-0.5	-0.5	0.4	-0.2	-0.9	1.2	-1.2	-0.4	0.2	0.0	-1.2	-0.2
Leg predicted mass (right)	0.1	0.4	1.5	0.0	-0.4	-0.4	0.1	-0.3	-0.9	1.0	-1.2	-0.4	0.1	-0.0	-1.2	-0.2
Average weekly champagne plus white wine intake	0.1	0.1	0.3	0.3	0.0	0.0	0.1	0.3	0.5	0.1	0.1	0.5	0.3	0.5	0.2	0.5
Hearing aid user	0.1	0.1	0.8	0.1	0.2	0.3	-0.1	0.0	0.2	-0.9	0.1	-0.6	-0.1	0.1	0.3	0.5
Illnesses of father: High blood pressure	0.1	0.1	0.2	-0.3	0.2	0.0	-0.3	-0.2	-0.2	-0.0	-0.4	-0.1	-0.2	-0.5	0.1	-0.2
Basal metabolic rate	0.1	0.6	2.4	-0.1	-0.7	-0.7	0.1	-0.5	-1.0	0.9	-1.5	-0.7	-0.0	-0.3	-1.3	-0.4
Irritability	0.1	0.1	1.0	0.1	-0.3	-0.4	0.2	-0.1	0.1	0.5	0.0	-1.0	0.3	0.1	0.2	0.4
Diastolic blood pressure, automated reading	0.1	0.4	1.2	0.2	0.9	0.9	0.2	0.4	0.7	1.0	-0.7	0.2	0.4	-0.5	1.1	0.5
Pain experienced in last month	0.1	0.2	1.1	-0.1	-0.2	-0.2	-0.1	-0.2	-0.5	0.4	0.3	-1.0	-0.2	-0.5	-0.5	-0.8
Basal cell carcinoma (self-reported)	0.1	0.1	1.0	-0.0	0.1	-0.0	-0.1	-0.1	0.3	0.3	-0.1	-1.0	0.0	-0.1	0.4	0.1
Neuroticism (Nagel 2018)	0.0	0.0	0.1	0.3	-0.0	-0.3	-0.3	-0.1	0.0	-0.1	-0.2	0.1	-0.1	-0.3	0.1	0.1
Ulcerative Colitis (UC)	0.0	0.1	0.3	0.0	-0.2	-0.3	0.1	0.1	0.4	0.1	0.5	-0.2	-0.0	-0.0	0.4	0.4
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.0	0.1	0.4	-0.1	-0.2	-0.3	-0.1	-0.2	0.3	-0.6	-0.0	0.3	-0.1	-0.2	0.3	-0.2
Hair Pigment	0.0	0.2	0.3	-0.5	-0.4	-0.3	-0.4	-0.5	-0.6	-0.6	-0.2	-0.3	-0.3	-0.4	-0.4	0.3
Hand grip strength (left)	0.0	0.1	0.3	0.0	-0.3	-0.5	0.5	0.1	-0.3	0.2	-0.3	0.3	0.3	0.5	-0.2	-0.1
Angina	0.0	0.1	0.2	-0.3	-0.3	-0.4	-0.2	-0.2	0.1	-0.5	0.0	0.3	-0.0	0.0	0.2	0.2
Diabetes (father)	0.0	0.1	0.2	-0.4	0.0	-0.1	0.3	-0.1	-0.2	-0.3	-0.1	-0.0	0.5	0.0	0.1	-0.3
Trunk fat mass	0.0	0.2	1.3	0.0	-0.1	-0.2	-0.5	-0.1	0.0	0.6	-1.1	-0.3	-0.0	-0.2	0.2	0.2
Father’s age at death	0.0	0.1	0.3	0.3	0.0	-0.2	0.2	0.1	-0.3	0.3	0.1	0.1	0.0	0.0	-0.6	0.1
Loud music exposure frequency	0.0	0.0	0.2	0.1	-0.2	-0.5	0.1	0.1	0.1	0.3	0.1	0.0	-0.2	-0.2	-0.0	-0.2
Illnesses of father: Heart disease	0.0	0.0	0.1	0.1	0.1	0.0	-0.1	0.0	-0.3	0.1	-0.3	-0.2	-0.1	-0.1	-0.1	-0.2
Back pain experienced in last month	0.0	0.1	0.3	-0.0	-0.2	-0.1	-0.1	-0.1	0.2	0.1	-0.3	0.5	-0.1	-0.2	0.4	0.1

Hub : Genes

KCNAB3

Models

Trait associations