Hub : Genes

FOLH1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0570	0.0230	4.9e-08	0.050	0.077	0.082	0.076	0.082	8.9e-07	1.2e-09	3.4e-10	1.5e-09	3.1e-10
2	ROSMAP	Brain Pre-frontal Cortex	0.1111	0.0407	0.0e+00	0.172	0.161	0.145	0.161	0.164	1.4e-21	4.1e-20	3.3e-18	4.0e-20	1.4e-20
3	TCGA	Glioblastoma Multiforme	0.1890	0.0970	5.9e-03	0.056	0.073	0.069	NA	0.045	8.8e-03	3.2e-03	4.0e-03	NA	1.7e-02
4	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0990	0.0550	7.9e-03	0.060	0.047	0.051	NA	0.050	2.4e-04	1.1e-03	6.9e-04	NA	8.0e-04
5	TCGA	Prostate Adenocarcinoma	0.0333	0.0190	7.5e-04	0.014	0.020	0.020	NA	0.010	1.3e-02	2.9e-03	3.4e-03	NA	2.7e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	1.9	3.1	9.4	0.6	0.7	3.1	-2.1	0.7
Bipolar Disorder or Schizophrenia	0.6	1.6	4.0	2.0	1.2	1.0	-0.3	1.1
Depressed Affect (Nagel 2018)	1.3	2.8	5.3	2.0	1.2	-2.3	-1.2	1.2
Depression (Nagel 2018)	0.9	1.4	2.7	0.5	1.4	0.3	-1.3	1.6
Intelligence (Savage-Jansen 2018)	0.9	2.7	6.5	0.8	1.6	2.5	-1.7	1.0
Neuroticism (Nagel 2018)	0.4	0.9	2.4	1.3	0.5	-1.5	-0.3	0.2
Schizophrenia (2018)	0.9	1.9	4.4	2.1	1.0	-1.2	1.4	0.8
Schizophrenia vs Biploar Disorder	1.6	2.2	6.1	0.6	-0.2	-2.0	2.5	-0.5
Worry (Nagel 2018)	0.2	0.5	1.0	1.0	0.8	-0.5	0.6	0.3
Alzheimer’s Disease (in mother)	1.0	1.2	1.8	1.0	1.3	0.4	-1.2	1.3
Alzheimer’s Disease (in father)	0.3	0.3	0.7	-0.3	0.9	0.3	0.0	0.8
Alzheimer’s Disease (including proxy)	1.9	2.7	5.4	1.4	2.3	0.3	-1.0	2.2
Crohns Disease (2017)	0.5	1.2	4.6	0.4	-0.8	-2.1	0.5	-0.5
Irritable Bowel Disease (IBD)	0.4	0.9	2.5	-0.2	-1.1	-1.6	0.3	-0.8
Ulcerative Colitis (UC)	0.5	0.9	2.1	-0.1	-0.9	-1.5	1.0	-0.7
Major Depression (MDD)	7.8	9.4	15.5	3.8	3.7	-1.7	-1.0	3.9
Reaction Time	0.5	0.9	1.9	1.1	0.7	0.1	1.4	0.8
Verbal and Numeric Reasoning (VNR)	0.9	2.1	3.5	1.2	1.8	1.9	-1.1	1.0
Breast Cancer	0.3	0.7	1.2	1.0	0.2	-0.9	-1.1	0.5
Ovarian Cancer	0.1	0.1	0.1	-0.3	0.3	0.3	-0.0	0.2
Prostate Cancer	1.0	1.3	2.9	-1.7	-1.5	0.7	-0.5	-1.0
Age at First Birth	1.3	1.9	2.6	-1.3	-1.6	1.4	-0.8	-1.6
Bipolar Disorder (2011)	1.3	1.3	4.0	0.7	1.0	2.0	-0.9	0.4
Body Mass Index (BMI) (2010)	0.3	0.5	0.8	0.9	0.0	-0.8	0.9	-0.1
Coronary Artery Disease (CAD)	0.1	0.1	0.4	0.4	-0.0	0.6	0.1	-0.3
Crohns Disease (2012)	0.2	0.3	0.6	-0.0	-0.8	-0.4	-0.3	-0.7
Mean Putamen Volume	1.1	1.3	2.2	-1.0	-1.5	0.9	-1.0	-1.2
Fasting Glucose	1.1	1.3	2.9	-0.1	1.7	1.6	0.5	0.7
HbA1C	1.9	2.1	3.6	-1.9	-1.5	1.3	-1.1	-1.2
HDL Cholesterol	5.8	9.6	14.6	0.6	3.8	3.3	-2.8	3.8
LDL Cholesterol	0.3	0.5	0.9	-0.7	-0.1	0.9	-0.9	-0.3
Lupus	0.3	0.4	0.8	0.5	0.9	-0.6	0.6	0.6
Neuroticism (2016)	1.4	2.0	4.2	2.1	1.7	-0.8	-0.6	1.3
Primary Biliary Cirrhosis	0.0	0.1	0.2	0.2	0.1	0.2	-0.5	0.1
Rheumatoid Arthritis	0.7	1.0	2.5	0.2	0.0	-1.5	1.6	0.2
Schizophrenia (2014)	1.1	2.5	8.0	2.8	1.4	-0.7	1.1	0.8
Triglycerides	1.7	2.8	4.3	2.1	1.6	-2.0	1.3	1.3
Type 2 Diabetes (T2D) (2012)	1.3	1.5	4.4	1.6	0.2	0.3	-2.1	0.6
Ulcerative Colitis	0.1	0.2	0.4	-0.4	-0.6	0.3	0.1	-0.6
Blood Eosinophil Count	0.6	4.4	8.2	-1.0	-2.9	-2.1	1.8	-2.2
Blood Platelet Count	1.3	14.6	25.4	-5.0	-4.5	1.6	1.8	-4.7
Blood Red Count	1.0	9.3	21.4	-4.6	-2.8	3.2	-0.2	-2.6
Blood White Count	3.4	24.9	50.7	-5.3	-7.1	0.1	1.8	-6.5
Heel T-Score	1.9	15.1	42.2	-4.5	-1.0	6.5	-3.5	0.3
BMI	0.9	5.3	11.7	3.4	1.6	-2.9	1.2	1.6
Height	1.5	29.5	66.6	5.7	8.2	0.8	-2.6	6.4
Waist Hip Ratio (WHR)	0.7	3.3	8.1	1.9	2.9	0.7	0.3	2.1
Systolic Blood Pressure	1.9	9.6	19.0	-0.2	-4.4	-2.2	-3.5	-3.4
Smoking Status	2.5	6.1	13.6	2.8	3.7	1.0	-0.7	2.7
Allergy or Eczema	0.2	0.5	1.9	0.3	0.1	0.1	-1.4	0.5
Cardiovascular Disease	1.0	3.4	8.0	0.8	-2.3	-2.8	-0.5	-1.7
Hypothyroidism (self reported)	0.4	1.0	2.7	-1.3	-0.7	0.4	-1.6	-0.2
Respiratory disease	0.1	0.2	0.7	0.3	-0.5	-0.4	-0.3	-0.8
Type 2 Diabetes (T2D) (2018)	1.5	2.7	6.4	2.5	2.0	-0.3	-0.7	1.6
Lung FEV1/FVC ratio	0.2	1.1	2.2	-1.5	-0.9	1.2	-0.8	-0.5
Lung FVC	0.2	1.0	2.7	-1.6	-0.5	1.4	0.2	-0.5
Neuroticism	0.2	0.5	1.5	1.2	0.5	-0.7	0.4	-0.4
Chronotype (morning person)	0.9	2.2	7.1	0.1	-1.4	-2.7	1.1	-0.8
Hair Pigment	0.3	9.6	22.0	-0.3	1.7	4.7	-4.4	1.9
Tanning	0.2	1.8	4.0	2.0	0.7	-1.6	1.3	0.5
Hand grip strength (left)	1.5	3.9	8.0	-2.8	-0.8	2.6	-1.9	-0.6
Number of treatments/medications taken	0.5	0.9	2.1	1.3	-0.5	-1.4	0.5	-0.5
Average weekly spirits intake	1.2	1.5	5.4	-2.3	-1.3	0.1	-0.4	-0.6
Sensitivity / hurt feelings	0.4	0.8	1.4	0.3	-0.9	-1.2	0.7	-1.1
Frequency of depressed mood in last 2 weeks	1.1	1.6	3.0	0.9	1.2	-0.4	-1.7	1.6
Hearing difficulty/problems: Yes	1.7	2.6	8.0	1.1	0.6	-2.8	1.8	0.5
Relative age of first facial hair	0.4	0.8	1.7	0.7	1.3	0.5	-0.6	1.1
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.3	1.1	0.8	-0.3	-0.3	0.6
Ever used hormone-replacement therapy (HRT)	2.2	2.8	5.5	-1.1	-2.0	-0.3	1.8	-2.3
Ever had hysterectomy (womb removed)	0.1	0.1	0.4	-0.4	-0.4	-0.6	-0.1	-0.1
Systolic blood pressure, automated reading	1.2	3.5	7.1	-0.6	-2.7	-0.8	-2.1	-2.2
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.6	0.1	-0.6	-0.6	0.5	-0.7
Angina	2.0	2.7	7.4	2.7	1.2	-1.6	-0.7	1.2
Medication for hormone replacement therapy	1.0	1.1	1.9	-1.0	-1.1	0.2	1.2	-1.4
Vitamin and mineral supplements	0.6	0.8	2.7	0.4	0.4	1.0	-1.6	0.4
Supplements: Zinc	0.5	0.5	1.9	0.6	0.3	0.4	1.4	-0.0
Medication: Co-codamol	2.4	2.7	5.8	1.7	2.1	-0.7	-0.1	2.4
Medication: Metformin	2.3	3.2	6.9	2.6	2.2	-1.1	0.5	1.6
Diabetes (father)	0.9	1.1	3.1	-0.7	-1.4	0.0	0.1	-1.8
Diabetes (mother)	2.7	3.5	5.3	1.2	2.3	1.5	-1.9	2.2
Severe depression (siblings)	0.4	0.4	1.7	-0.6	-0.0	0.2	1.3	0.0
Pack years adult smoking proportion	3.3	5.0	8.8	2.7	2.6	-0.7	-1.2	3.0
Impedance of leg (right)	0.0	0.1	0.4	-0.3	-0.1	0.7	-0.3	-0.3
Leg fat-free mass (left)	0.7	3.7	6.4	2.2	2.5	-1.1	-0.3	2.5
Trunk fat percentage	0.3	1.3	3.9	2.0	0.8	-1.0	-0.0	0.9
Hand grip strength (right)	0.6	1.7	3.7	-1.9	-0.9	1.2	-1.4	-0.6
Townsend deprivation index at recruitment	2.7	3.8	6.2	2.5	2.4	-1.0	-0.3	2.4
Current tobacco smoking	3.1	5.1	9.3	2.6	3.0	-1.3	0.1	2.7
Average weekly fortified wine intake	1.0	1.1	2.0	-1.1	-1.1	0.8	0.7	-1.4
Maternal smoking around birth	1.3	1.8	4.3	0.6	-0.9	-2.1	1.6	-1.0
Fed-up feelings	0.7	1.3	4.4	0.5	-0.2	-2.1	-1.4	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.9	-0.1	-0.1	0.1	-1.4	0.3
Relative age voice broke	0.1	0.2	0.6	-0.8	-0.3	0.4	-0.2	0.0
Taking other prescription medications	0.3	0.4	1.4	1.2	-0.1	-0.8	0.2	-0.4
Age when periods started (menarche)	0.4	1.0	3.0	-1.7	-0.2	1.4	0.2	-0.4
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	2.8	0.2	-0.0	-1.7	0.1	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.9	5.5	-1.5	-0.8	2.3	0.9	-0.7
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.7	-0.2	-0.7	-0.0	0.2	-0.9
Qualifications: CSEs or equivalent	2.5	3.2	5.7	2.4	1.9	-1.4	-1.0	2.0
Serious illness, injury or assault to yourself	0.7	0.8	2.4	0.8	0.2	-1.5	-0.6	0.8
High blood pressure	1.6	4.4	11.4	0.1	-2.5	-3.4	-1.6	-1.3
Hayfever, allergic rhinitis or eczema	0.1	0.3	1.0	0.5	0.2	0.2	-1.0	0.4
Multivitamins +/- minerals	0.7	0.9	2.8	-0.5	-0.4	-1.0	1.7	-0.4
Stomach or abdominal pain in last month	3.3	4.1	8.9	2.1	1.4	-3.0	1.5	1.7
Supplements: Glucosamine	2.0	2.6	6.7	-0.7	-1.4	-0.9	2.6	-1.7
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.0	-1.0	-0.4	0.7	0.8	-0.9
Medication: Atenolol	0.7	0.9	3.0	0.1	-0.1	-1.7	1.2	0.3
Medication: Levothyroxine sodium	0.4	0.6	1.0	-0.8	-1.0	0.2	-0.6	-1.0
Sitting height	0.9	6.6	10.4	2.5	3.2	-0.3	-2.5	3.2
Chronic bronchitis/emphysema (father)	0.3	0.4	1.4	0.1	-0.3	1.2	-0.3	-0.4
High blood pressure (mother)	0.5	0.7	2.2	0.9	-0.2	-1.5	-0.6	0.2
Body mass index (BMI)	0.3	1.1	2.5	1.6	0.2	-1.6	0.6	0.4
Impedance of leg (left)	0.1	0.3	0.8	-0.0	0.2	0.9	-0.9	0.0
Leg predicted mass (left)	0.7	3.5	6.1	2.1	2.5	-1.1	-0.2	2.4
Trunk fat mass	0.6	2.7	6.4	2.5	1.6	-1.1	-0.3	1.7
Waist circumference	1.0	3.6	8.5	2.9	2.1	-1.3	0.5	1.8
Number of incorrect matches in round	0.3	0.5	2.2	-1.5	-0.1	0.2	-0.2	0.7
Past tobacco smoking	0.9	1.7	3.4	-1.5	-1.8	0.6	0.2	-1.6
Alcohol usually taken with meals	0.2	0.3	0.5	-0.7	-0.4	-0.3	0.6	-0.5
Nervous feelings	0.1	0.2	0.4	0.4	0.4	0.6	-0.3	0.0
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	2.7	1.6	0.9	-0.9	-0.3	1.0
Hearing difficulty/problems with background noise	1.3	2.0	6.1	-0.3	-0.9	-2.5	1.4	-1.0
Hair/balding pattern: Pattern 2	0.3	0.4	0.7	-0.6	0.2	0.9	0.7	-0.4
Had menopause	0.6	0.7	2.3	0.6	0.9	0.0	1.5	0.2
Had other major operations	0.1	0.1	0.3	0.2	0.1	-0.0	0.6	-0.6
Forced vital capacity (FVC)	0.7	2.6	4.5	0.1	2.1	1.2	-1.6	2.1
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.0	7.4	-1.5	-0.5	2.7	0.2	-0.2
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	0.9	0.4	0.7	-0.9	-0.0	1.0
Qualifications: None of the above	1.1	2.3	3.9	1.9	1.4	-2.0	0.3	1.5
Financial difficulties in last 2 years	0.5	0.7	1.2	-0.7	-1.1	-0.9	0.1	-0.9
Mouth/teeth dental problems	2.8	4.3	7.3	-2.1	-1.7	2.7	-1.0	-2.4
Heart attack	0.1	0.1	0.2	-0.0	-0.3	0.2	-0.3	-0.4
Allergy	0.1	0.2	0.6	-0.8	0.1	-0.1	0.4	0.2
Pain all over the body in last month	1.2	1.3	2.4	1.5	1.2	-0.3	-0.7	1.4
Diabetes (self-reported)	1.0	1.6	4.4	0.8	0.9	1.1	-2.1	0.9
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	2.7	-0.2	-0.1	-0.4	-1.6	0.6
Medication: Ramipril	0.4	0.5	1.3	0.2	-1.1	-0.5	-0.0	-1.2
Medication: Simvastatin	0.2	0.3	1.1	0.1	-0.4	1.1	-0.2	-0.6
Fluid intelligence score	1.4	2.8	4.0	1.2	2.0	1.6	-1.9	1.6
Illnesses of siblings	0.7	0.9	2.6	0.6	1.6	0.8	0.2	1.0
Neuroticism score	0.7	1.5	2.8	1.7	1.2	-1.4	-0.6	1.1
Weight	1.1	5.5	9.9	3.1	2.9	-1.4	-0.3	2.8
Impedance of arm (right)	0.0	0.1	0.2	-0.2	-0.2	0.4	0.3	-0.1
Arm fat percentage (right)	0.3	1.2	2.5	1.6	-0.0	-1.6	0.8	0.3
Trunk fat-free mass	1.3	7.6	16.1	2.9	4.0	-0.7	-0.4	3.5
Hip circumference	0.6	2.7	6.2	2.5	1.4	-1.8	0.3	1.3
Time employed in main current job	0.3	0.3	0.7	0.5	0.8	0.7	-0.0	0.5
Alcohol intake versus 10 years previously	1.5	2.2	3.1	1.8	1.7	-0.9	1.5	1.4
Father’s age at death	1.1	1.5	5.5	-0.2	0.7	2.4	-1.1	0.4
Worrier / anxious feelings	0.5	1.0	1.9	1.4	1.2	-0.4	1.1	0.5
Frequency of tiredness / lethargy in last 2 weeks	2.2	3.5	6.1	2.5	2.0	-2.2	0.5	1.5
Falls in the last year	0.8	1.1	4.0	1.1	-0.3	-2.0	0.3	-0.5
Hair/balding pattern: Pattern 3	0.9	1.3	3.9	0.7	-0.8	-2.0	1.0	-0.7
Number of live births	1.6	2.3	4.6	-0.5	-1.0	-2.0	2.1	-1.3
Forced expiratory volume in 1-second (FEV1)	0.6	2.1	4.6	-1.3	0.5	2.1	-1.9	0.6
Pulse rate	0.8	1.3	3.9	0.7	0.5	2.0	-1.3	0.0
Happiness	0.3	0.4	1.1	-0.6	-0.5	1.1	-0.0	-0.5
Noisy workplace	1.3	1.6	4.1	1.3	0.7	-2.0	0.8	1.1
Qualifications: A levels/AS levels or equivalent	1.0	2.1	4.4	-2.1	-1.1	2.0	-0.6	-0.9
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	1.0	0.1	-0.4	-1.0	-0.0	0.1
Mouth/teeth dental problems: Dentures	0.6	1.0	2.7	0.2	1.3	0.4	-0.8	1.6
Asthma	0.4	0.8	2.2	-0.1	-1.3	0.0	-0.2	-1.5
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.3	2.5	-0.9	-1.0	1.6	-1.4	-0.5
Medication: Cholesterol lowering	0.6	1.0	2.1	1.4	0.7	-1.2	0.9	0.4
Depression (self-reported)	0.3	0.3	1.0	0.5	-0.4	0.3	0.3	-1.0
Medication: Lansoprazole	1.5	1.7	3.6	1.2	1.2	0.6	-1.9	1.4
Prospective memory result	3.0	3.7	11.2	1.8	0.3	-3.4	1.9	0.4
Lung cancer (father)	1.3	1.6	3.7	0.8	1.7	-0.7	-0.1	1.9
Illnesses of mother	0.2	0.3	0.6	-0.5	0.1	0.8	0.7	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.1	6.3	-1.2	0.8	2.5	-1.3	0.6
Pulse wave Arterial Stiffness index	0.9	1.0	1.9	-1.4	-1.0	1.2	-0.4	-0.9
Impedance of arm (left)	0.1	0.2	0.4	-0.4	-0.4	0.7	0.3	-0.6
Arm fat mass (right)	0.5	2.1	5.1	2.3	1.1	-1.7	0.3	1.2
Trunk predicted mass	1.3	7.5	15.9	2.9	4.0	-0.8	-0.5	3.5
Standing height	1.8	17.6	38.6	3.8	6.2	0.2	-2.0	5.5
Length of working week for main job	0.1	0.1	0.3	0.1	-0.0	0.1	-0.6	0.0
Exposure to tobacco smoke at home	2.4	2.7	6.6	1.9	0.9	-2.6	1.2	1.1
Breastfed as a baby	0.1	0.1	0.4	-0.0	0.1	0.7	0.1	-0.1
Tense / ‘highly strung’	0.6	0.9	1.6	0.1	-1.0	-1.0	1.2	-1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	1.6	2.4	6.0	2.4	1.6	-0.9	0.4	1.6
Hair/balding pattern: Pattern 4	0.9	2.3	4.2	-1.2	-1.0	1.9	-2.0	-1.0
Birth weight of first child	0.7	1.3	1.8	-0.9	1.1	1.1	-1.1	1.4
Peak expiratory flow (PEF)	2.1	4.9	11.9	-2.1	-0.2	3.5	-2.9	0.3
Pulse wave reflection index	1.2	1.5	4.7	-2.2	-1.5	-0.2	0.1	-0.7
Ever highly irritable/argumentative for 2 days	0.0	0.1	0.2	0.4	0.2	0.1	-0.3	0.0
Loud music exposure frequency	1.6	1.7	4.3	0.7	-0.3	-2.1	1.9	-0.3
Qualifications: O levels/GCSEs or equivalent	0.7	1.2	3.0	-1.0	-0.3	1.7	-1.2	-0.5
Mouth/teeth dental problems: Bleeding gums	2.5	3.2	8.6	2.0	0.6	-2.9	1.1	1.4
Blood clot in the leg (DVT)	0.2	0.2	0.6	0.4	0.3	-0.4	0.8	0.3
Medication: Paracetamol	0.3	0.4	0.9	-0.7	-0.8	0.1	-0.9	-0.2
Headache pain in last month	0.1	0.2	1.1	-0.2	0.1	1.1	-0.2	0.1
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	3.9	-0.7	0.7	2.0	-0.0	0.3
Glaucoma (self-reported)	1.5	1.8	3.5	1.0	1.9	0.9	-0.8	1.7
Gout (self-reported)	0.3	0.4	1.0	-0.2	-1.0	-0.4	-0.1	-0.8
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	1.5	-0.8	-1.0	0.4	-1.2	-0.9
Medication: Amlodipine	0.7	1.0	2.9	1.3	-0.3	-1.7	0.4	-0.1
Medication: Ventolin 100micrograms inhaler	2.3	3.0	6.2	1.8	0.9	-2.5	2.1	0.5
Birth weight	1.3	2.9	7.2	-1.0	0.9	2.7	-2.1	0.9
Chronic bronchitis/emphysema (mother)	0.2	0.3	0.5	0.3	0.4	-0.4	-0.6	0.7
High blood pressure (siblings)	2.9	4.1	10.0	-1.7	-3.2	-1.7	0.2	-2.2
Forced vital capacity (FVC), Best measure	0.6	2.3	3.9	0.0	2.0	1.7	-1.1	1.8
Body fat percentage	0.3	1.3	3.8	2.0	0.5	-1.4	0.1	0.8
Leg fat percentage (right)	0.3	0.9	2.2	1.5	0.1	-1.5	0.3	0.3
Arm fat-free mass (right)	1.2	5.9	11.3	2.8	3.4	-0.9	-0.8	3.0
Exposure to tobacco smoke outside home	1.0	1.3	2.8	1.7	1.0	-1.2	-0.4	1.1
Comparative body size at age 10	1.5	4.3	8.4	-2.0	-2.9	1.0	-2.3	-1.6
Number of full brothers	0.3	0.4	0.9	-0.6	-1.0	-0.2	0.3	-0.8
Worry too long after embarrassment	0.1	0.2	0.8	-0.2	-0.5	0.3	-0.0	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	1.1	0.3	0.0	1.0	0.3	-0.2
Wheeze or whistling in the chest in last year	0.9	1.6	4.2	1.8	0.4	-2.0	0.4	0.5
Number of children fathered	0.4	0.4	1.0	0.5	0.8	-0.0	-0.4	1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.3	0.8	0.8	-1.0	1.2	0.4
Age at first live birth	2.0	3.5	4.8	-2.0	-2.0	2.1	-0.1	-2.2
Pulse wave peak to peak time	1.4	1.7	2.9	1.7	1.5	-1.2	0.1	1.4
Health satisfaction	2.8	3.6	7.5	2.4	1.1	-2.7	1.6	0.9
Shortness of breath walking on level ground	8.2	9.8	20.0	4.5	2.8	-3.7	1.3	2.5
Qualifications: College or University degree	2.3	7.2	10.0	-3.2	-3.1	2.5	-1.2	-2.9
Eye problems/disorders: None of the above	0.6	0.7	1.1	-1.0	-0.7	1.0	-0.3	-0.8
Mouth/teeth dental problems: Loose teeth	1.4	1.6	3.9	2.0	1.0	-1.1	-0.7	1.3
Emphysema/chronic bronchitis	0.1	0.2	0.7	0.8	0.0	-0.1	-0.2	-0.3
Medication for pain relief, constipation, heartburn	0.2	0.3	0.6	-0.5	0.6	0.8	-0.5	0.4
Neck or shoulder pain in last month	0.8	1.2	2.9	0.1	-0.6	-1.7	1.4	-0.8
Medication: Blood pressure	1.4	2.5	5.9	-0.1	-2.1	-2.4	-0.8	-1.3
Angina (self-reported)	1.8	2.3	6.8	2.6	1.1	-1.5	-0.5	1.0
Migraine (self-reported)	0.2	0.3	0.6	-0.1	0.4	0.8	0.7	-0.2
Medication: Ibuprofen	0.5	0.6	1.2	-0.2	0.1	1.0	-1.1	0.8
Medication: Allopurinol	0.9	1.3	3.2	-1.0	-1.8	-0.3	-0.3	-1.4
Medication: Omeprazole	0.8	0.9	1.4	-1.2	-1.0	0.2	1.1	-1.0
Medication: Seretide 50 evohaler	1.2	1.4	3.3	1.8	0.9	-1.3	0.8	0.7
Mean time to correctly identify matches	0.5	1.0	3.5	0.8	0.7	0.2	1.9	0.7
Heart disease (mother)	2.9	3.6	6.4	-0.9	-2.4	-0.3	2.2	-2.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.5	3.3	-1.0	-1.3	0.6	-1.8	-1.1
Whole body fat mass	0.6	2.5	6.0	2.4	1.4	-1.4	-0.2	1.6
Leg fat mass (right)	0.5	1.9	4.3	2.1	0.9	-1.7	0.0	1.2
Arm predicted mass (right)	1.2	6.2	12.0	2.7	3.5	-0.9	-0.8	3.2
Pulse rate, automated reading	1.8	5.8	10.3	1.5	2.3	3.2	-2.7	1.8
Alcohol intake frequency.	0.1	0.2	0.7	-0.1	0.5	0.1	-0.5	0.8
Comparative height size at age 10	1.4	7.8	17.5	2.5	4.2	0.2	-1.0	3.8
Number of full sisters	2.7	3.2	4.6	-1.5	-2.1	-0.8	2.1	-2.1
Suffer from ‘nerves’	1.0	1.6	2.7	0.7	1.4	1.5	-1.6	0.7
Overall health rating	0.8	1.6	6.3	1.3	0.1	-2.5	0.4	0.3
Chest pain or discomfort	2.2	3.2	5.5	2.4	1.3	-2.3	1.6	0.9
Had major operations	0.3	0.4	0.9	0.6	0.0	-0.9	0.6	-0.5
Age at last live birth	1.6	2.3	5.8	-1.8	-0.6	2.4	-1.5	-0.3
Family relationship satisfaction	1.2	1.5	2.3	1.5	1.3	-1.1	1.2	1.1
Leg pain on walking	0.4	0.5	2.2	0.4	-0.3	-1.5	0.2	0.0
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	3.2	0.4	1.4	0.9	-0.7	1.8
Commuting to job workplace: Car/motor vehicle	1.3	1.5	3.0	0.7	1.0	1.4	-1.7	1.1
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	1.6	-0.6	-0.4	1.3	0.7	-1.0
Medication: Aspirin	0.4	0.5	1.3	1.1	-0.1	-1.0	0.2	-0.2
Supplements: Vitamin C	0.0	0.0	0.1	0.3	0.1	0.0	-0.0	0.2
Knee pain experienced in last month	2.5	3.9	7.1	2.1	2.6	0.8	-0.9	2.7
Hypertension (Self-reported)	1.6	4.4	13.3	0.4	-2.2	-3.6	-1.4	-1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.8	2.1	4.5	1.3	2.1	-0.1	0.8	1.9
Illnesses of father: Heart disease	1.6	2.2	4.8	0.2	-1.1	-1.7	2.2	-1.5
Illnesses of siblings: Diabetes	0.0	0.0	0.1	-0.0	-0.2	0.0	0.2	-0.1
Smoking status: Previous	0.9	1.3	2.7	1.3	1.6	-0.3	-0.2	1.4
Forced expiratory volume in 1-second (FEV1), predicted	1.8	3.7	8.4	-0.6	1.1	2.9	-2.8	1.0
Whole body fat-free mass	1.1	6.3	12.5	2.7	3.5	-1.0	-0.5	3.2
Leg fat-free mass (right)	0.7	3.9	6.8	2.2	2.6	-0.9	-0.7	2.6
Arm fat percentage (left)	0.2	0.9	2.2	1.3	-0.3	-1.5	0.8	-0.0
Average weekly red wine intake	0.1	0.2	0.3	-0.3	-0.5	0.3	0.4	-0.6
Handedness (chirality/laterality): Left-handed	3.0	3.7	6.8	1.8	2.0	-2.0	0.3	2.6
Mood swings	1.3	2.3	5.5	2.1	0.6	-2.4	-0.8	0.9
Loneliness, isolation	4.0	5.5	13.4	3.7	2.5	-2.1	0.5	1.9
Long-standing illness, disability or infirmity	1.0	1.5	3.3	1.8	1.0	-1.4	-0.2	1.2
Ever had bowel cancer screening	1.5	1.7	7.3	-0.7	-0.1	-0.9	2.7	-0.3
Diabetes diagnosed by doctor	1.4	2.2	3.4	1.8	1.8	0.5	-1.3	1.6
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.8	2.0	0.5	1.3	-0.1	-0.3	1.4
Friendships satisfaction	1.0	1.2	4.2	-0.8	0.1	2.0	-1.1	0.0
Qualifications: nursing, teaching	2.1	3.2	6.0	-2.0	-2.1	0.8	0.8	-2.5
Commuting to job workplace: Walk	1.6	1.7	2.7	1.5	1.2	-1.7	1.0	1.0
Eye problems/disorders: Cataract	0.6	0.6	1.2	0.6	0.8	-0.9	-0.4	1.1
Mouth/teeth dental problems: Mouth ulcers	1.6	2.6	6.6	-0.1	-0.9	-2.6	2.3	-0.4
Medication for cholesterol	1.4	2.2	3.0	-0.3	1.5	1.6	-1.7	1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	4.3	0.6	-0.5	-0.9	2.1	-0.7
Back pain experienced in last month	1.4	2.1	3.8	-1.9	-1.9	-0.2	0.4	-1.7
Mineral and other dietary supplements	2.6	3.5	5.9	0.9	1.8	2.3	-2.4	1.6
Breast cancer (self-reported)	0.4	0.5	1.1	0.4	-0.4	-0.6	1.0	-0.9
Asthma (self-reported)	0.2	0.5	1.4	0.2	-1.0	-0.1	-0.1	-1.2
Osteoporosis (self-reported)	1.1	1.4	3.3	0.4	-0.0	-1.8	1.8	-0.5
Osteoarthritis (self-reported)	1.0	1.3	2.6	1.6	1.1	-1.2	0.7	0.7
Medication: Aspirin	0.3	0.4	0.9	0.9	-0.1	-0.9	0.4	-0.3
Medication: Gliclazide	0.9	1.0	2.2	0.8	1.2	-0.1	-1.0	1.5
Illnesses of father: None of the above (group 1)	3.8	4.6	9.7	1.9	3.1	-0.4	-0.5	3.1
Smoking status: Current	4.0	6.4	11.5	3.0	3.4	-1.5	0.4	3.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.3	2.7	4.9	-2.2	-2.0	1.2	0.7	-1.7
Whole body water mass	1.1	6.4	12.7	2.7	3.6	-0.9	-0.6	3.3
Leg predicted mass (right)	0.7	3.9	6.9	2.2	2.6	-0.9	-0.6	2.6
Arm fat mass (left)	0.4	1.7	4.4	2.1	1.0	-1.3	0.1	1.2
Number of self-reported non-cancer illnesses	0.7	1.3	3.5	1.9	0.4	-1.7	0.1	0.0
Average weekly champagne plus white wine intake	2.0	2.8	4.7	2.2	2.0	-1.1	-0.4	2.1
Miserableness	0.9	1.5	4.4	1.1	0.5	-1.1	-2.1	0.8
Guilty feelings	0.4	0.6	2.7	0.1	-0.4	-0.1	-1.6	0.2
Wears glasses or contact lenses	0.7	0.8	2.9	-0.3	-0.6	1.7	-0.1	-0.8
Ever taken oral contraceptive pill	0.6	0.6	1.8	-0.1	0.7	0.6	-1.4	0.6
Hearing aid user	1.0	1.2	4.2	0.8	0.3	-2.0	0.0	1.0
Mother’s age at death	0.1	0.1	0.6	0.1	0.1	0.2	0.8	-0.1
Financial situation satisfaction	1.4	1.7	3.1	1.2	0.9	-1.8	1.7	0.6
Tinnitus: Yes, now most or all of the time	0.9	1.1	2.6	0.0	0.9	-1.4	0.3	1.6
Commuting to job workplace: Public transport	2.3	2.7	5.5	-1.1	-1.8	-0.4	1.9	-2.3
Eye problems/disorders: Glaucoma	2.7	3.2	7.3	1.7	2.7	0.7	-0.3	2.3
Medication: Blood pressure	1.8	3.4	10.3	0.5	-1.6	-3.2	1.6	-1.3
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.8	-0.4	-0.9	-0.5	-0.1	-0.9
Supplements: Fish oil (including cod liver oil)	1.5	2.0	4.2	-0.6	-1.3	-1.7	2.1	-1.0
High cholesterol (Self-reported)	0.1	0.2	0.4	0.7	-0.4	-0.1	0.1	-0.6
Medication: Bendroflumethiazide	1.7	2.6	9.1	0.5	-1.5	-3.0	0.5	-1.2
Medication: Paracetamol	0.1	0.2	0.8	-0.4	-0.3	0.2	-0.9	0.1
Medication: Lisinopril	1.6	2.0	6.7	0.8	-0.9	-2.6	1.2	-0.8
Medication: Atorvastatin	0.8	1.0	2.7	1.7	0.9	-0.7	0.6	0.7
Illnesses of father: High blood pressure	1.0	1.2	3.0	-0.5	-1.7	-0.5	-1.4	-0.8
Alcohol drinker status: Never	0.4	0.5	1.9	-0.7	-0.1	1.4	-0.5	-0.2
Ever smoked	0.5	0.8	1.8	1.1	1.3	-0.3	-0.0	1.1
Basal metabolic rate	1.2	6.6	12.2	2.9	3.5	-1.1	-0.6	3.3
Leg fat percentage (left)	0.3	1.1	3.1	1.8	0.3	-1.4	0.1	0.5
Arm fat-free mass (left)	1.4	7.3	13.2	3.0	3.6	-1.2	-1.0	3.5
Number of operations (self-reported)	0.3	0.5	1.2	0.7	0.0	-0.7	1.1	-0.4
Average weekly beer plus cider intake	1.4	2.1	3.2	1.8	1.4	-1.6	0.4	1.6
Irritability	1.4	2.3	4.9	2.2	1.6	-1.2	0.2	1.6
Risk taking	0.9	1.2	3.5	1.0	0.5	-1.2	1.9	0.4
Ever had prostate specific antigen (PSA) test	0.3	0.3	1.1	-1.1	-0.5	0.6	-0.1	0.2
Fractured/broken bones in last 5 years	0.9	1.1	4.3	1.0	0.5	-2.1	0.4	0.3
Age started oral contraceptive pill	1.0	1.3	4.0	0.6	0.8	-1.2	2.0	0.4
Diastolic blood pressure, automated reading	1.1	3.5	6.5	-1.1	-2.5	-0.5	-2.4	-2.0
Ever depressed for a whole week	1.6	2.0	3.6	1.5	1.8	-0.8	0.0	1.9
Unable to work because of sickness or disability	0.3	0.4	0.9	0.9	0.6	-0.1	-0.6	0.8
Commuting to job workplace: Cycle	6.8	8.2	13.1	-3.5	-3.6	1.7	-0.4	-3.6
Myopia	0.6	0.9	4.1	-0.1	0.4	2.0	0.0	0.2
Vascular/heart problems diagnosed by doctor	1.5	4.0	14.1	-0.8	1.9	3.8	1.1	0.9
Cholesterol lowering medication	0.2	0.3	1.0	1.0	-0.3	0.4	-0.0	-0.7
Medication: Omeprazole (e.g. Zanprol)	0.6	0.8	1.2	-0.9	-1.1	0.3	0.8	-1.1
Pain experienced in last month	0.3	0.4	1.0	-0.6	-0.8	-0.1	0.4	-1.0
Supplements: Calcium	0.2	0.3	0.7	0.8	0.2	-0.1	0.7	-0.3
Basal cell carcinoma (self-reported)	1.1	1.3	3.2	-1.0	-1.8	-1.4	0.2	-0.8
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.2	0.1	-0.3	0.1	-0.2	-0.5
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	1.1	0.3	-0.1	-0.6	1.0	-0.1
Heart disease (siblings)	0.8	0.9	1.4	0.5	1.0	0.8	-1.2	1.2
Alcohol drinker status: Previous	1.1	1.3	3.2	0.9	1.1	-0.5	-1.0	1.8
Pack years of smoking	3.6	5.3	9.5	2.7	2.7	-0.3	-1.4	3.1
Impedance of whole body	0.1	0.5	1.5	-0.5	-0.3	1.2	-0.9	-0.3
Leg fat mass (left)	0.5	2.0	4.7	2.2	1.0	-1.6	0.0	1.2
Arm predicted mass (left)	1.7	8.6	15.8	3.2	4.0	-1.2	-1.0	3.7