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chr16:511,080-5,281,856

Best TWAS P=9.21e-14 · Best GWAS P=2.87e-15 conditioned to 0.000587

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	CORO7	0.08	0.08	lasso	2	0.06	4.3e-08	5.7	-5.8	8.8e-09	-0.05	0.01	0.99	FALSE
2	CommonMind	Brain Pre-frontal Cortex	DNASE1	0.07	0.02	lasso	4	0.02	4.6e-04	-5.7	6.6	3.7e-11	-0.37	0.35	0.64	FALSE
3	CommonMind	Brain Pre-frontal Cortex	SLC9A3R2	0.15	0.09	enet	7	0.10	7.8e-12	-5.6	6.1	8.5e-10	0.06	0.00	1.00	FALSE
4	GTEx	Adipose Subcutaneous	NMRAL1	0.31	0.33	lasso	4	0.35	9.0e-30	5.1	5.2	1.8e-07	0.00	0.19	0.81	FALSE
5	GTEx	Adipose Visceral Omentum	NMRAL1	0.36	0.27	enet	20	0.27	3.7e-14	4.8	5.7	1.4e-08	0.05	0.44	0.55	FALSE
6	GTEx	Adipose Visceral Omentum	NLRC3	0.18	0.14	lasso	3	0.10	4.9e-06	-6.2	-6.3	3.6e-10	0.26	0.83	0.03	FALSE
7	GTEx	Adipose Visceral Omentum	AC006111.1	0.18	0.12	enet	12	0.10	1.1e-05	6.2	5.6	2.0e-08	-0.12	0.67	0.02	FALSE
8	GTEx	Artery Aorta	NMRAL1	0.43	0.42	lasso	8	0.42	4.7e-25	5.1	5.2	1.5e-07	0.00	0.17	0.83	FALSE
9	GTEx	Artery Coronary	NMRAL1	0.40	0.34	lasso	5	0.34	3.5e-12	5.3	5.3	1.0e-07	0.00	0.11	0.89	FALSE
10	GTEx	Artery Tibial	CDIP1	0.14	0.14	lasso	3	0.16	1.0e-12	5.1	-5.1	2.8e-07	-0.01	0.20	0.80	FALSE
11	GTEx	Brain Cerebellar Hemisphere	CDIP1	0.47	0.47	lasso	6	0.52	1.2e-15	5.1	5.7	1.2e-08	0.04	0.04	0.96	FALSE
12	GTEx	Brain Cerebellar Hemisphere	NMRAL1	0.62	0.66	lasso	3	0.68	2.2e-23	5.1	5.2	2.6e-07	0.01	0.26	0.74	FALSE
13	GTEx	Brain Cerebellum	CDIP1	0.47	0.54	lasso	7	0.52	8.3e-18	5.1	5.5	3.8e-08	0.00	0.16	0.83	FALSE
14	GTEx	Brain Cerebellum	HMOX2	0.21	0.15	lasso	3	0.14	7.2e-05	4.8	5.1	3.0e-07	0.06	0.04	0.93	FALSE
15	GTEx	Brain Cerebellum	NMRAL1	0.81	0.55	lasso	10	0.62	4.6e-23	4.9	5.2	2.2e-07	0.01	0.36	0.64	FALSE
16	GTEx	Brain Nucleus accumbens basal ganglia	HMOX2	0.28	-0.01	lasso	5	-0.01	7.1e-01	4.8	-5.5	4.4e-08	-0.03	0.06	0.36	FALSE
17	GTEx	Breast Mammary Tissue	NMRAL1	0.17	0.18	lasso	2	0.15	5.2e-08	5.1	5.2	2.5e-07	0.00	0.17	0.82	FALSE
18	GTEx	Breast Mammary Tissue (Male)	NMRAL1	0.20	0.11	lasso	4	0.10	2.4e-03	5.1	5.2	1.5e-07	0.00	0.05	0.47	FALSE
19	GTEx	Breast Mammary Tissue (Female)	NMRAL1	0.29	0.01	lasso	6	0.00	2.7e-01	3.3	5.1	3.0e-07	0.05	0.07	0.18	FALSE
20	GTEx	Cells EBV-transformed lymphocytes	CDIP1	0.16	0.10	lasso	7	0.06	6.8e-03	5.0	-5.3	1.4e-07	-0.06	0.09	0.76	FALSE
21	GTEx	Cells Transformed fibroblasts	CDIP1	0.33	0.35	lasso	3	0.36	1.3e-28	5.1	-5.2	2.5e-07	-0.01	0.17	0.83	FALSE
22	GTEx	Cells Transformed fibroblasts	NMRAL1	0.15	0.12	lasso	5	0.12	1.6e-09	5.1	5.2	2.2e-07	0.02	0.18	0.82	FALSE
23	GTEx	Cells Transformed fibroblasts	AC006111.1	0.14	0.02	lasso	5	0.04	4.8e-04	6.2	7.5	9.2e-14	-0.45	0.18	0.04	TRUE
24	GTEx	Colon Sigmoid	CDIP1	0.25	0.04	lasso	6	0.04	1.6e-02	5.0	-5.8	5.2e-09	-0.05	0.07	0.31	FALSE
25	GTEx	Colon Sigmoid	NMRAL1	0.43	0.35	lasso	5	0.31	1.7e-11	5.1	5.2	2.0e-07	0.00	0.22	0.78	FALSE
26	GTEx	Colon Transverse	CDIP1	0.21	0.07	lasso	4	0.09	4.5e-05	4.6	-5.2	1.7e-07	0.00	0.19	0.78	FALSE
27	GTEx	Esophagus Gastroesophageal Junction	CDIP1	0.25	0.24	lasso	5	0.25	1.2e-09	4.6	-5.2	2.2e-07	-0.03	0.11	0.89	FALSE
28	GTEx	Esophagus Gastroesophageal Junction	NMRAL1	0.47	0.28	lasso	4	0.26	4.3e-10	4.8	5.1	2.9e-07	0.04	0.31	0.68	FALSE
29	GTEx	Esophagus Mucosa	NMRAL1	0.23	0.13	lasso	4	0.12	2.7e-08	5.1	5.2	2.4e-07	0.01	0.22	0.78	FALSE
30	GTEx	Heart Atrial Appendage	NMRAL1	0.27	0.25	lasso	2	0.23	1.1e-10	5.1	5.2	2.5e-07	0.00	0.18	0.82	FALSE
31	GTEx	Lung	NMRAL1	0.16	0.11	enet	3	0.13	3.4e-10	5.1	5.2	2.1e-07	0.01	0.21	0.79	FALSE
32	GTEx	Muscle Skeletal	CDIP1	0.07	0.07	lasso	2	0.06	6.1e-07	5.3	-5.2	1.5e-07	-0.01	0.10	0.90	FALSE
33	GTEx	Nerve Tibial	NMRAL1	0.32	0.37	lasso	3	0.36	5.2e-27	5.1	5.1	3.0e-07	0.00	0.20	0.80	FALSE
34	GTEx	Pancreas	DNASE1	0.33	0.08	lasso	7	0.13	3.1e-06	-5.7	6.5	6.1e-11	-0.52	0.34	0.60	FALSE
35	GTEx	Pituitary	CLUAP1	0.32	0.26	lasso	3	0.17	5.6e-05	-5.1	-5.2	2.2e-07	0.57	0.11	0.43	TRUE
36	GTEx	Pituitary	NMRAL1	0.31	0.18	enet	12	0.23	1.9e-06	4.9	5.3	9.6e-08	0.01	0.08	0.88	FALSE
37	GTEx	Skin Not Sun Exposed Suprapubic	CACNA1H	0.23	0.16	lasso	5	0.16	4.2e-09	6.1	-5.8	6.7e-09	-0.05	0.93	0.04	FALSE
38	GTEx	Skin Sun Exposed Lower leg	CDIP1	0.08	0.06	lasso	3	0.05	6.8e-05	5.1	-5.3	1.1e-07	-0.01	0.13	0.80	FALSE
39	GTEx	Skin Sun Exposed Lower leg	CACNA1H	0.22	0.21	lasso	1	0.20	8.8e-17	6.1	-6.1	1.2e-09	-0.07	0.96	0.04	TRUE
40	GTEx	Skin Sun Exposed Lower leg	RNPS1	0.10	0.01	lasso	6	0.04	6.3e-04	3.2	-5.5	5.0e-08	-0.11	0.17	0.52	FALSE
41	GTEx	Skin Sun Exposed Lower leg	LA16c-358B7.3	0.12	0.11	lasso	2	0.11	2.8e-09	6.8	-6.7	1.8e-11	0.03	0.13	0.87	TRUE
42	GTEx	Spleen	CLUAP1	0.31	0.23	lasso	5	0.26	3.0e-07	-5.1	-6.6	5.4e-11	0.63	0.05	0.87	FALSE
43	GTEx	Testis	CLUAP1	0.37	0.06	lasso	5	0.13	1.9e-06	-5.1	-7.2	4.5e-13	0.48	0.27	0.16	FALSE
44	GTEx	Testis	NMRAL1	0.27	0.20	enet	6	0.22	2.4e-10	5.1	5.6	2.3e-08	0.01	0.18	0.82	FALSE
45	GTEx	Thyroid	CDIP1	0.15	0.14	lasso	3	0.15	1.5e-11	4.6	-5.3	9.9e-08	-0.01	0.11	0.89	FALSE
46	METSIM	Adipose	PKD1	0.06	0.02	bslmm	370	0.03	9.5e-06	-5.9	5.9	3.0e-09	0.08	0.03	0.97	FALSE
47	ROSMAP	Brain Pre-frontal Cortex	SLC9A3R2	0.16	0.11	lasso	6	0.12	6.3e-15	-6.3	6.8	1.3e-11	0.03	0.00	1.00	FALSE
48	ROSMAP	Brain Pre-frontal Cortex	CDIP1	0.13	0.18	lasso	2	0.17	3.6e-21	5.3	5.5	2.9e-08	0.01	0.09	0.91	FALSE
49	ROSMAP	Brain Pre-frontal Cortex	DNASE1	0.13	0.06	bslmm	372	0.07	5.2e-09	-5.4	5.3	1.1e-07	-0.21	1.00	0.00	FALSE
50	YFS	Blood	TSC2	0.03	0.02	lasso	4	0.02	7.6e-08	-5.5	5.9	4.1e-09	0.02	0.04	0.96	FALSE
51	YFS	Blood	ZNF597	0.02	0.00	blup	332	0.00	1.0e-02	4.4	-6.1	1.1e-09	0.43	0.13	0.19	FALSE
52	The Cancer Genome Atlas	Breast Invasive Carcinoma	C16orf5	0.02	0.03	blup	37	0.03	9.7e-08	4.8	-5.4	5.2e-08	-0.02	0.01	0.99	FALSE
53	The Cancer Genome Atlas	Breast Invasive Carcinoma	DNASE1	0.05	0.00	enet	15	0.01	3.2e-03	-6.3	5.7	1.0e-08	-0.40	0.02	0.16	FALSE
54	The Cancer Genome Atlas	Breast Invasive Carcinoma	SEPT12	0.11	0.04	enet	15	0.09	1.7e-17	3.5	-5.3	1.2e-07	0.05	0.00	0.26	TRUE
55	The Cancer Genome Atlas	Breast Invasive Carcinoma	TSC2	0.02	0.03	lasso	1	0.02	1.8e-05	-5.5	5.5	3.1e-08	0.00	0.08	0.80	FALSE
56	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	TPSB2	0.17	0.08	lasso	3	0.06	5.3e-04	6.1	-5.6	2.2e-08	-0.07	0.00	0.98	FALSE
57	The Cancer Genome Atlas	Colon Adenocarcinoma	BTBD12	0.05	0.01	blup	41	0.02	1.5e-02	3.2	-6.0	1.8e-09	0.67	0.00	0.74	FALSE
58	The Cancer Genome Atlas	Glioblastoma Multiforme	CORO7	0.12	0.06	lasso	6	0.06	8.3e-03	6.0	-6.7	2.3e-11	-0.02	0.01	0.87	TRUE
59	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TRAP1	0.11	0.01	blup	43	0.05	9.4e-04	-7.6	7.2	7.0e-13	-0.40	0.02	0.53	FALSE
60	The Cancer Genome Atlas	Brain Lower Grade Glioma	CASKIN1	0.02	0.00	blup	38	0.01	4.5e-02	3.7	-5.9	3.4e-09	-0.02	0.03	0.08	TRUE
61	The Cancer Genome Atlas	Brain Lower Grade Glioma	CORO7	0.26	0.43	lasso	3	0.44	5.0e-54	5.0	-5.5	4.1e-08	-0.08	0.30	0.70	FALSE
62	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	DNASE1	0.20	0.10	lasso	4	0.11	9.9e-06	-5.7	7.1	1.2e-12	-0.57	0.09	0.37	FALSE
63	The Cancer Genome Atlas	Lung Adenocarcinoma	C16orf5	0.03	0.03	lasso	2	0.02	1.3e-03	5.3	-5.3	1.3e-07	0.00	0.00	0.98	FALSE
64	The Cancer Genome Atlas	Prostate Adenocarcinoma	LOC342346	0.06	0.02	blup	34	0.02	1.2e-03	5.1	-5.3	1.1e-07	-0.05	0.00	0.99	FALSE
65	The Cancer Genome Atlas	Thyroid Carcinoma	CASKIN1	0.06	0.02	blup	38	0.04	1.5e-04	-5.7	-6.5	6.2e-11	0.00	0.01	0.94	FALSE
66	The Cancer Genome Atlas	Thyroid Carcinoma	DNASE1	0.04	0.01	blup	32	0.02	1.2e-02	-6.2	6.0	2.7e-09	-0.64	0.02	0.19	FALSE
67	The Cancer Genome Atlas	Thyroid Carcinoma	SLC9A3R2	0.06	0.03	lasso	5	0.03	3.7e-04	-5.6	6.9	5.8e-12	0.08	0.01	0.96	TRUE