TWAS hub - TPSB2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Caudate basal ganglia	0.6490	0.0850	6.5e-07	0.433	NA	0.423	NA	0.428	8.3e-14	NA	1.9e-13	NA	1.3e-13
2	GTEx	Brain Hippocampus	0.4165	0.1135	2.2e-03	0.174	NA	0.130	NA	0.225	7.1e-05	NA	6.1e-04	NA	5.2e-06
3	GTEx	Brain Nucleus accumbens basal ganglia	0.3890	0.1240	5.1e-03	0.297	NA	0.175	NA	0.281	1.2e-08	NA	2.0e-05	NA	3.3e-08
4	GTEx	Breast Mammary Tissue (Male)	0.2649	0.1758	1.6e-01	0.004	NA	-0.013	NA	-0.002	2.5e-01	NA	8.7e-01	NA	3.5e-01
5	GTEx	Esophagus Mucosa	0.4060	0.0630	4.6e-10	0.235	NA	0.285	NA	0.266	9.6e-16	NA	2.8e-19	NA	6.2e-18
6	GTEx	Lung	0.2811	0.0639	9.9e-06	0.133	NA	0.150	NA	0.165	2.2e-10	NA	1.5e-11	NA	1.2e-12
7	GTEx	Skin Sun Exposed Lower leg	0.1620	0.0540	5.5e-03	0.136	NA	0.161	NA	0.149	2.5e-11	NA	2.8e-13	NA	2.5e-12
8	METSIM	Adipose	0.1344	0.0354	1.7e-06	0.099	0.045	0.078	0.092	0.094	1.3e-14	2.5e-07	9.5e-12	1.2e-13	6.8e-14
9	ROSMAP	Brain Pre-frontal Cortex	0.4731	0.0399	0.0e+00	0.502	0.434	0.513	0.505	0.515	1.7e-74	3.7e-61	1.0e-76	5.0e-75	4.0e-77
10	TCGA	Breast Invasive Carcinoma	0.1314	0.0366	7.1e-15	0.034	0.070	0.072	NA	0.062	1.4e-07	4.5e-14	1.7e-14	NA	1.1e-12
11	TCGA	Cervical Squamous Cell Carcinoma	0.1700	0.0790	1.8e-03	0.084	0.049	0.050	NA	0.062	5.9e-05	1.9e-03	1.8e-03	NA	5.3e-04
12	TCGA	Colon Adenocarcinoma	0.0900	0.0570	7.9e-03	0.065	0.010	0.008	NA	0.023	1.3e-04	8.4e-02	1.0e-01	NA	1.7e-02
13	TCGA	Head and Neck Squamous Cell Carcinoma	0.0822	0.0327	2.3e-07	0.072	0.060	0.092	NA	0.090	1.8e-08	2.6e-07	1.7e-10	NA	2.8e-10
14	TCGA	Kidney Renal Clear Cell Carcinoma	0.0629	0.0281	2.7e-05	0.053	0.047	0.048	NA	0.050	1.4e-06	4.7e-06	3.7e-06	NA	2.5e-06
15	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0470	0.0240	6.0e-03	0.041	0.040	0.038	NA	0.051	2.1e-03	2.3e-03	3.1e-03	NA	6.4e-04
16	TCGA	Brain Lower Grade Glioma	0.0776	0.0323	2.5e-07	0.057	0.067	0.060	NA	0.050	4.8e-07	4.7e-08	2.2e-07	NA	2.0e-06
17	TCGA	Lung Adenocarcinoma	0.0799	0.0335	1.5e-06	0.057	0.056	0.060	NA	0.071	3.0e-07	3.5e-07	1.3e-07	NA	1.2e-08
18	TCGA	Lung Squamous Cell Carcinoma	0.1018	0.0375	5.7e-08	0.093	0.089	0.088	NA	0.094	9.9e-11	2.6e-10	3.4e-10	NA	8.6e-11
19	TCGA	Pancreatic Adenocarcinoma	0.1210	0.0640	4.7e-03	0.007	0.015	0.027	NA	0.020	1.6e-01	7.7e-02	2.7e-02	NA	4.8e-02
20	TCGA	Prostate Adenocarcinoma	0.2077	0.0557	4.2e-12	0.136	0.136	0.162	NA	0.158	4.7e-14	4.4e-14	1.2e-16	NA	3.0e-16

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20
Ever highly irritable/argumentative for 2 days	9.0	10.8	14.6	-3.0	-2.9	-2.8	3.4	3.1	3.8	3.8	2.8	-2.9	2.9	2.8	3.8	3.8	3.0	3.8	-2.6	3.5	3.8	3.6	3.3
Ever depressed for a whole week	4.3	5.2	10.6	-1.9	-1.8	-1.7	2.8	2.9	2.9	3.1	1.5	-1.3	1.6	1.9	3.3	2.4	1.2	2.8	-1.0	2.7	3.2	1.9	2.0
Birth weight	4.2	9.1	13.5	-2.9	-2.1	-2.8	3.2	3.2	3.2	3.2	2.9	-2.8	3.5	1.1	3.5	3.5	2.9	3.1	-2.1	3.5	3.5	2.6	3.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.8	4.4	9.9	-2.1	-1.7	-2.2	2.2	3.1	2.8	2.5	2.1	-1.7	1.2	2.5	1.9	1.8	1.8	1.7	-0.8	2.0	1.9	3.0	1.3
Illnesses of father: None of the above (group 1)	3.4	4.1	7.0	2.1	2.6	2.3	-2.6	-0.8	-1.5	-1.7	-2.0	2.3	-1.1	0.9	-2.3	-2.4	-2.1	-2.6	2.3	-2.1	-2.2	-0.3	-2.2
Heart disease (mother)	3.2	3.9	6.7	-2.4	-2.4	-2.6	1.7	1.2	2.2	2.1	2.5	-2.3	1.5	1.0	1.8	1.8	2.1	1.8	-1.8	2.4	2.0	1.8	1.0
Commuting to job workplace: Car/motor vehicle	3.2	3.7	10.4	-2.4	-3.0	-3.2	1.0	-0.3	0.3	0.8	2.9	-2.8	1.7	-0.5	1.0	1.7	2.7	1.4	-1.7	2.0	1.2	0.6	2.1
Blood Eosinophil Count	2.9	22.2	54.2	3.6	1.3	3.3	-4.6	-5.6	-5.3	-5.5	-3.5	2.8	-5.1	-7.3	-5.2	-4.5	-3.2	-4.0	0.7	-5.3	-5.5	-7.4	-4.5
Forced expiratory volume in 1-second (FEV1)	2.9	9.7	21.4	-2.8	-1.6	-3.1	3.2	2.1	2.1	2.3	3.3	-3.1	4.6	3.6	3.0	3.5	3.5	2.4	-0.1	3.6	3.2	4.2	3.8
Severe depression (siblings)	2.8	3.1	5.0	-1.2	-1.3	-1.0	1.8	1.7	2.1	1.9	1.4	-1.5	1.8	1.6	1.9	2.1	1.6	2.0	-1.7	1.9	2.0	2.2	2.0
Forced expiratory volume in 1-second (FEV1), Best measure	2.8	9.1	17.5	-2.3	-1.1	-2.5	3.5	2.4	2.4	2.6	2.8	-2.6	4.2	3.9	3.2	3.4	3.0	2.3	0.4	3.4	3.3	4.2	3.7
Trunk predicted mass	2.8	15.7	28.1	-2.3	-0.7	-2.6	5.0	4.6	4.7	4.9	2.3	-2.1	5.1	4.7	5.3	4.4	2.4	3.7	0.4	4.1	5.0	4.6	4.8
Ever unenthusiastic/disinterested for a whole week	2.7	3.3	5.5	-1.8	-1.7	-2.1	1.7	2.0	2.3	2.3	1.7	-1.5	1.0	0.9	2.3	1.9	1.4	2.0	-1.4	2.0	2.1	1.2	2.1
Trunk fat-free mass	2.7	15.3	27.2	-2.1	-0.6	-2.5	4.9	4.5	4.6	4.8	2.2	-1.9	5.1	4.8	5.2	4.3	2.3	3.6	0.5	4.0	4.9	4.6	4.7
Medication: Co-codamol	2.5	2.9	6.5	-2.0	-2.1	-1.3	1.9	2.0	1.8	1.8	1.8	-1.4	0.9	2.6	1.9	1.4	1.4	1.7	-0.4	1.6	1.5	1.9	1.5
Pulse wave peak to peak time	2.5	2.9	8.4	-1.2	-0.8	-1.2	1.4	1.2	1.4	1.6	1.7	-1.6	2.9	2.2	1.6	1.8	1.8	1.2	-0.1	2.4	2.1	2.4	1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.4	5.2	9.7	-2.7	-2.1	-3.1	2.0	1.9	1.7	1.7	2.8	-2.5	2.1	1.6	2.4	2.5	2.7	2.2	-0.8	2.7	2.5	2.4	2.0
Irritability	2.3	3.9	6.2	-2.1	-1.7	-1.8	1.6	2.0	2.4	2.5	1.8	-1.8	1.9	-0.5	2.3	2.1	1.9	2.5	-2.3	2.4	2.5	1.2	1.1
Fasting Glucose	2.2	2.7	8.5	2.4	2.2	2.6	-0.6	-1.0	-1.6	-1.5	-2.9	2.2	0.0	-0.8	-1.0	-1.1	-2.1	-1.4	1.3	-1.8	-0.9	-1.2	-1.1
Frequency of tenseness / restlessness in last 2 weeks	2.2	3.4	5.5	-2.1	-1.3	-1.7	1.6	1.6	2.2	2.0	1.8	-1.6	1.4	1.5	2.2	2.0	1.7	2.2	-1.4	2.3	2.3	2.0	1.3
Peak expiratory flow (PEF)	2.2	5.0	12.4	-1.7	-1.1	-2.0	2.2	1.7	2.2	2.2	2.0	-2.1	3.5	2.2	2.3	2.6	2.3	1.9	-0.4	2.3	2.4	2.9	2.8
Arm predicted mass (right)	2.2	11.4	20.8	-2.2	-0.9	-2.7	4.0	4.0	4.0	4.2	2.4	-2.0	4.6	3.5	4.5	3.7	2.2	3.1	0.3	3.6	4.2	3.5	4.1
Whole body fat-free mass	2.2	12.4	22.0	-1.8	-0.3	-2.2	4.3	4.4	4.3	4.5	1.9	-1.5	4.5	4.7	4.7	3.7	1.8	3.1	0.8	3.5	4.3	4.3	4.1
Arm predicted mass (left)	2.2	11.2	19.9	-2.3	-1.0	-2.7	3.9	4.1	4.2	4.3	2.3	-2.0	4.1	3.3	4.5	3.7	2.2	3.2	-0.1	3.5	4.1	3.6	3.9
Osteoarthritis (self-reported)	2.1	2.7	7.1	-1.3	-1.3	-0.8	1.9	1.9	2.7	2.5	1.1	-1.1	1.1	-0.5	2.2	1.6	1.0	2.0	-1.9	1.8	2.1	0.7	1.0
Smoking status: Current	2.1	3.4	8.9	-1.4	-1.7	-1.7	2.3	2.2	2.0	2.2	1.2	-1.3	1.7	-0.2	3.0	2.2	1.3	2.4	-1.0	2.0	2.7	0.5	1.4
Whole body water mass	2.1	12.2	22.4	-1.8	-0.3	-2.2	4.2	4.3	4.3	4.5	1.9	-1.5	4.3	4.7	4.6	3.6	1.8	3.1	0.7	3.5	4.3	4.3	4.0
Arm fat-free mass (left)	2.1	10.4	18.9	-2.0	-0.8	-2.6	3.9	4.0	4.0	4.1	2.1	-1.8	4.0	3.3	4.3	3.5	2.0	3.1	0.1	3.4	4.0	3.4	3.7
Arm fat-free mass (right)	2.0	10.3	18.8	-1.9	-0.5	-2.4	3.9	4.0	4.0	4.1	1.9	-1.6	4.3	3.6	4.3	3.5	1.8	2.9	0.5	3.3	3.9	3.4	4.0
Forced vital capacity (FVC)	1.9	7.4	17.4	-2.3	-0.9	-2.5	2.8	2.0	1.6	1.8	2.7	-2.4	4.2	3.7	2.8	3.0	2.7	2.0	0.8	3.2	3.0	3.8	3.3
Financial difficulties in last 2 years	1.9	2.6	4.7	-1.7	-1.6	-1.3	1.6	2.2	2.0	1.9	1.5	-1.3	1.7	0.2	2.1	1.7	1.2	1.5	-0.5	1.9	1.9	0.9	1.7
Neuroticism score	1.9	3.9	7.5	-2.1	-1.7	-2.0	2.2	2.3	2.7	2.7	1.6	-1.5	0.8	-1.0	2.2	1.8	1.5	2.4	-2.5	2.3	2.3	0.8	1.0
Frequency of tiredness / lethargy in last 2 weeks	1.9	3.1	7.9	-1.4	-0.9	-1.0	2.8	1.9	2.6	2.5	0.9	-0.9	1.3	0.3	2.8	1.9	1.0	2.1	-0.7	2.0	2.5	1.1	1.1
Impedance of arm (left)	1.9	8.6	17.7	2.4	1.3	2.7	-3.0	-2.5	-3.3	-3.6	-2.3	2.2	-3.9	-1.1	-4.2	-3.6	-2.3	-3.2	0.6	-3.6	-4.0	-1.8	-3.6
Forced vital capacity (FVC), Best measure	1.9	7.1	14.1	-2.1	-0.7	-2.1	3.3	2.2	1.9	2.2	2.5	-2.2	3.8	3.3	3.0	3.0	2.5	2.1	0.7	3.2	3.2	3.5	3.2
Smoking Status	1.8	4.4	7.4	-2.1	-2.3	-2.3	1.8	1.9	2.0	2.0	2.1	-2.2	2.6	-0.1	2.7	2.6	2.2	2.3	-1.1	2.1	2.3	0.8	2.6
Ever used hormone-replacement therapy (HRT)	1.8	2.2	5.1	1.6	1.1	2.0	-0.5	-0.5	-0.7	-0.7	-2.2	1.9	-1.6	-2.3	-0.9	-1.5	-2.0	-0.8	0.2	-1.6	-1.0	-2.2	-1.9
Systolic blood pressure, automated reading	1.8	5.1	9.3	2.2	2.2	1.6	-2.6	-2.8	-2.8	-2.8	-2.2	2.0	-1.6	-2.6	-2.2	-2.1	-2.1	-1.9	1.0	-2.5	-2.5	-3.0	-1.5
Medication: Ibuprofen (e.g. Nurofen)	1.8	2.2	4.1	-1.5	-1.4	-0.9	1.9	2.0	1.9	1.7	1.3	-1.1	0.7	0.6	1.9	1.5	1.1	2.0	-1.2	1.7	1.8	1.0	1.2
Pulse wave Arterial Stiffness index	1.8	2.1	6.6	1.1	0.7	1.1	-1.0	-0.9	-1.0	-1.2	-1.6	1.5	-2.6	-1.8	-1.2	-1.5	-1.6	-0.9	0.1	-2.1	-1.7	-1.9	-1.2
Neck or shoulder pain in last month	1.8	2.6	5.4	-1.3	-0.9	-0.8	2.0	2.2	2.3	2.3	1.0	-1.0	2.1	-0.5	2.1	1.8	1.0	1.6	-1.0	1.5	1.9	0.5	1.8
Basal metabolic rate	1.8	9.8	17.5	-1.6	-0.4	-2.1	3.8	4.1	4.0	4.1	1.7	-1.4	3.8	4.2	4.1	3.2	1.6	2.8	0.6	3.1	3.8	3.9	3.4
Chronic bronchitis/emphysema (father)	1.7	2.0	4.0	-1.4	-1.9	-0.6	1.7	1.1	1.6	1.6	0.9	-1.1	0.2	-0.8	1.9	1.6	1.1	2.0	-1.6	1.3	1.7	0.5	1.6
Happiness	1.7	2.0	3.7	1.4	1.3	1.2	-1.9	-1.7	-1.6	-1.6	-1.3	1.3	-1.3	-0.3	-1.7	-1.5	-1.3	-1.5	1.2	-1.5	-1.7	-1.1	-1.0
Exposure to tobacco smoke at home	1.7	1.9	3.5	-1.7	-1.5	-1.6	1.4	0.7	1.0	0.8	1.8	-1.9	1.1	-0.2	1.0	1.6	1.9	1.3	-1.7	1.4	1.1	1.1	1.7
Pain type(s) experienced in last month: Hip pain	1.7	2.2	6.0	-1.4	-1.4	-0.5	1.7	2.4	2.5	2.2	1.0	-0.8	0.1	0.3	2.1	1.2	0.8	2.0	-1.0	1.3	1.7	0.9	0.7
Sensitivity / hurt feelings	1.6	2.7	6.4	-1.8	-1.4	-1.4	1.7	2.3	2.5	2.3	1.1	-1.0	-0.3	0.3	1.7	1.4	1.0	2.0	-2.5	1.5	1.7	1.3	0.9
Diabetes (father)	1.6	1.9	3.6	-1.9	-1.7	-1.7	0.9	0.9	0.9	0.7	1.9	-1.9	0.4	-0.8	0.9	1.3	1.7	1.6	-1.9	1.7	1.2	0.5	1.3
Had other major operations	1.6	1.9	5.4	-0.8	-0.8	-0.5	2.2	2.0	2.3	2.2	0.3	-0.4	-0.1	1.1	2.0	1.3	0.4	1.9	-0.9	1.0	1.6	1.3	0.9
Lung FEV1/FVC ratio	1.5	7.5	12.3	-2.2	-2.4	-3.3	2.6	1.8	2.9	3.1	3.1	-3.1	2.9	2.6	2.4	3.2	3.3	2.1	-1.6	2.4	2.2	3.5	3.3
Medication: Metformin	1.5	2.2	5.4	-1.5	-1.2	-1.2	1.9	1.9	2.3	2.2	1.1	-1.1	0.8	0.3	1.4	1.2	1.0	1.5	-1.9	1.7	1.7	1.2	0.7
Diabetes (mother)	1.5	2.0	6.0	-1.4	-2.0	-1.2	1.6	1.1	1.5	1.5	1.0	-1.4	0.2	-2.0	1.2	1.4	1.3	1.5	-2.5	0.9	1.1	-0.2	1.2
Had menopause	1.5	1.8	4.1	1.6	2.0	1.3	-0.7	-1.3	-1.4	-1.0	-1.7	1.6	-0.3	-1.3	-1.0	-1.3	-1.7	-1.2	1.1	-1.5	-1.2	-1.9	-0.8
Medication: Lansoprazole	1.5	1.8	3.3	-1.5	-1.3	-0.9	1.1	1.4	1.2	1.3	0.9	-1.2	1.2	0.2	1.8	1.7	1.1	1.8	-1.1	1.5	1.7	1.0	1.7
Migraine (self-reported)	1.5	1.9	4.7	1.0	0.8	0.8	-1.0	-1.8	-1.7	-2.0	-0.9	0.9	-1.1	-1.5	-1.7	-1.6	-0.9	-1.3	0.4	-1.4	-1.6	-1.5	-2.2
Current tobacco smoking	1.4	2.3	6.7	-1.1	-1.4	-1.3	1.9	1.6	1.5	1.6	0.9	-1.0	1.5	-0.5	2.6	1.8	1.0	2.0	-0.8	1.6	2.3	0.1	1.1
Alcohol usually taken with meals	1.4	2.3	7.3	-1.0	-0.4	-0.9	1.5	2.0	1.9	1.7	1.1	-1.1	0.9	2.7	1.3	1.6	1.3	1.3	-0.8	1.1	1.1	2.7	1.9
Knee pain experienced in last month	1.4	2.2	4.9	-1.4	-1.6	-1.1	2.1	1.6	2.2	2.1	1.2	-1.2	0.7	-0.5	1.7	1.5	1.2	1.6	-1.6	1.4	1.6	0.8	0.9
Ever had prostate specific antigen (PSA) test	1.4	1.6	3.2	-1.1	-1.0	-0.7	1.8	1.3	1.5	1.4	0.6	-0.9	1.2	0.7	1.7	1.7	0.9	1.7	-1.0	1.0	1.4	0.8	1.6
Systolic Blood Pressure	1.3	6.5	13.8	2.0	2.5	1.5	-3.5	-3.7	-3.7	-3.6	-1.7	1.6	-1.4	-2.7	-3.0	-2.3	-1.6	-2.5	1.2	-2.5	-2.9	-2.9	-1.6
Impedance of arm (right)	1.3	6.0	13.5	1.8	0.7	2.2	-2.8	-2.2	-2.7	-3.0	-1.8	1.6	-3.5	-0.9	-3.7	-3.0	-1.7	-2.5	0.0	-2.9	-3.4	-1.2	-3.3
Worrier / anxious feelings	1.3	2.5	6.7	-1.3	-1.0	-1.0	2.6	2.1	2.1	2.1	0.7	-0.5	0.5	2.3	2.1	1.4	0.5	2.0	-0.7	1.3	1.7	1.8	1.1
Medication: Ibuprofen	1.3	1.6	5.0	-1.0	-1.0	-0.7	1.7	2.2	2.1	1.7	0.9	-0.5	0.3	1.1	1.6	1.0	0.5	1.6	-0.9	1.2	1.5	1.1	0.8
Leg fat-free mass (right)	1.3	7.0	21.8	-0.8	0.5	-1.1	3.1	3.6	3.4	3.6	0.9	-0.4	3.1	4.7	3.4	2.2	0.7	1.9	1.5	2.4	3.1	3.7	2.5
Leg predicted mass (right)	1.3	6.8	21.5	-0.7	0.5	-1.1	3.0	3.6	3.4	3.5	0.9	-0.4	3.1	4.6	3.4	2.2	0.7	1.9	1.5	2.4	3.1	3.7	2.5
Average weekly champagne plus white wine intake	1.3	1.8	3.8	-0.8	-0.6	-0.3	1.5	1.7	1.6	1.7	0.9	-1.1	1.3	0.9	1.3	1.7	1.5	1.4	-1.0	1.4	1.6	2.0	1.6
Commuting to job workplace: Cycle	1.3	1.6	3.5	-1.4	-0.8	-0.7	1.9	1.1	1.4	1.2	1.0	-0.9	0.3	1.6	1.3	1.2	1.0	1.6	-1.4	1.4	1.4	1.9	0.4
Impedance of whole body	1.3	6.5	14.4	1.4	0.1	1.8	-2.8	-2.5	-3.1	-3.4	-1.3	1.1	-3.2	-2.8	-3.8	-2.9	-1.3	-2.5	-0.5	-2.9	-3.6	-2.5	-3.1
Waist Hip Ratio (WHR)	1.2	5.2	13.8	1.6	0.4	0.6	-3.7	-2.4	-2.6	-2.5	-1.2	0.9	-2.2	-3.7	-2.9	-2.2	-1.2	-2.5	0.3	-2.2	-2.7	-3.3	-2.1
Neuroticism	1.2	2.9	7.5	-1.5	-1.2	-1.3	2.2	2.6	2.7	2.7	0.9	-0.8	0.9	-1.4	2.2	1.4	0.7	2.0	-1.7	1.9	2.1	0.1	0.8
Ever had hysterectomy (womb removed)	1.2	1.4	4.0	1.5	1.9	1.4	-0.3	-0.1	-0.2	-0.1	-1.8	1.8	-1.1	-0.6	-0.3	-1.2	-1.8	-0.7	0.6	-0.7	-0.1	-1.0	-2.0
Leg fat-free mass (left)	1.2	6.5	18.7	-0.8	0.3	-1.3	3.1	3.5	3.3	3.4	0.9	-0.5	3.0	4.3	3.3	2.2	0.8	1.9	1.2	2.4	3.0	3.5	2.4
Leg predicted mass (left)	1.2	6.6	18.2	-0.8	0.4	-1.2	3.2	3.5	3.3	3.5	0.9	-0.5	3.0	4.3	3.4	2.3	0.8	1.9	1.2	2.4	3.1	3.5	2.4
Falls in the last year	1.2	1.6	4.1	-0.9	-0.5	-0.7	1.6	1.9	1.8	2.0	0.5	-0.5	1.3	1.0	1.6	1.3	0.5	1.2	-0.7	1.2	1.5	1.1	1.1
Pulse rate	1.2	2.0	8.2	0.4	0.5	-0.1	-1.3	-1.8	-1.9	-1.9	-0.5	0.2	-1.3	-2.9	-1.3	-1.0	-0.4	-0.8	-0.0	-1.2	-1.5	-2.8	-1.0
Standing height	1.2	12.1	31.5	-1.6	-0.1	-1.5	4.6	4.3	3.9	4.2	1.9	-1.5	4.5	5.6	4.0	3.5	1.9	2.8	0.7	3.1	3.7	5.3	4.1
Age at last live birth	1.2	1.8	3.6	1.3	1.1	1.6	-1.5	-1.5	-1.3	-1.3	-1.2	1.2	-1.7	0.0	-1.6	-1.3	-1.1	-1.4	1.3	-1.9	-1.9	-0.8	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.5	9.5	-0.8	0.2	-0.9	1.3	1.6	1.6	1.7	1.2	-0.9	1.9	3.1	1.6	1.5	1.1	0.8	0.7	1.5	1.6	2.9	1.5
Height	1.1	21.2	42.0	-2.1	-0.1	-2.1	5.7	5.7	5.6	5.6	2.4	-2.1	5.9	6.3	5.7	5.0	2.7	4.4	-0.3	4.2	5.3	6.5	5.6
Angina	1.1	1.4	6.3	0.4	0.4	0.1	-1.6	-1.1	-0.6	-1.0	-0.3	0.4	-2.0	-2.5	-1.1	-1.1	-0.4	-0.6	-0.3	-1.2	-1.3	-2.0	-1.5
Qualifications: CSEs or equivalent	1.1	1.4	2.6	-1.6	-1.3	-1.2	1.0	1.6	1.6	1.2	1.3	-1.2	-0.2	0.1	1.0	1.0	1.2	1.4	-1.6	1.3	1.1	1.0	0.4
Sitting height	1.1	7.9	15.9	-2.1	-0.6	-2.2	4.0	3.5	3.4	3.3	2.1	-2.0	3.0	2.5	3.3	3.1	2.3	3.0	-0.9	2.8	3.1	3.5	3.1
Nervous feelings	1.1	2.0	4.3	-1.9	-1.4	-1.6	1.9	0.5	1.0	1.4	1.3	-1.5	0.9	-1.8	1.3	1.4	1.3	1.6	-2.1	1.6	1.5	-0.1	1.0
Tense / ‘highly strung’	1.1	1.9	4.9	-1.1	-0.7	-0.6	1.8	1.8	2.1	2.2	0.7	-0.8	1.0	0.6	1.6	1.3	0.9	1.7	-1.8	1.3	1.6	1.4	0.7
Leg pain on walking	1.1	1.4	4.2	-0.9	-0.5	-0.9	1.6	0.9	1.4	1.5	0.8	-0.6	0.8	0.1	2.0	1.2	0.7	1.5	-0.0	1.7	2.0	0.6	0.8
Guilty feelings	1.1	1.6	4.4	-1.1	-1.2	-0.6	1.7	1.0	1.2	1.4	0.6	-0.6	1.5	-0.2	2.0	1.4	0.7	1.7	-0.9	1.7	2.1	0.4	1.0
Illnesses of mother	1.0	1.2	3.1	1.2	1.5	1.5	-1.2	-0.5	-1.3	-1.3	-1.1	1.3	-0.2	0.3	-1.0	-1.0	-1.2	-1.4	1.8	-0.9	-0.8	-0.5	-0.6
Angina (self-reported)	1.0	1.3	5.8	0.5	0.5	0.3	-1.5	-0.9	-0.5	-0.9	-0.5	0.5	-2.0	-2.4	-1.0	-1.1	-0.5	-0.5	-0.3	-1.2	-1.2	-1.9	-1.5
Financial situation satisfaction	1.0	1.3	2.7	-1.1	-1.0	-0.7	1.2	1.6	1.4	1.3	1.1	-0.9	0.6	-0.7	1.5	1.1	1.0	1.4	-0.9	1.4	1.4	0.4	1.0
Alzheimer’s Disease (in father)	0.9	1.0	2.8	-0.9	-0.5	-0.6	1.1	0.4	0.4	0.5	0.8	-1.1	1.0	0.3	1.2	1.4	1.1	1.4	-1.0	1.2	1.3	0.5	1.7
Number of treatments/medications taken	0.9	1.6	7.8	0.2	-0.1	0.4	-0.4	-0.1	-0.2	-0.5	-0.8	0.9	-2.8	-2.8	-0.5	-1.3	-1.1	-0.1	-0.4	-0.8	-0.7	-2.3	-2.0
Taking other prescription medications	0.9	1.4	10.2	-0.1	-0.1	0.5	-0.6	0.1	0.2	-0.2	-0.4	0.5	-3.2	-2.7	-0.4	-1.0	-0.6	0.4	-1.2	-0.7	-0.7	-1.7	-1.8
Hearing difficulty/problems with background noise	0.9	1.4	5.3	-1.4	-0.8	-1.2	0.6	2.0	2.3	1.8	0.9	-0.7	-1.2	-0.3	1.4	0.8	0.6	1.4	-1.2	0.7	1.0	0.5	0.2
Prospective memory result	0.9	1.1	3.2	0.2	0.7	-0.7	-1.0	-1.5	-1.4	-1.1	0.6	-0.3	0.9	-1.5	-1.2	-0.9	0.2	-1.8	1.4	-0.2	-1.0	-1.5	-0.9
Qualifications: College or University degree	0.9	2.8	25.2	0.3	0.4	0.1	2.0	0.8	0.7	1.2	0.1	0.1	1.9	5.0	1.0	1.0	0.1	0.2	1.8	0.9	1.2	3.2	1.5
Diabetes diagnosed by doctor	0.9	1.4	8.3	-1.0	-1.0	-0.9	1.1	1.5	2.0	1.7	0.7	-0.9	0.1	-1.2	0.6	0.9	0.8	1.0	-2.9	0.9	0.9	0.4	0.5
Mother’s age at death	0.9	1.2	8.0	0.4	0.7	0.6	1.2	1.7	1.2	1.1	-0.4	0.6	0.7	2.8	0.8	0.5	-0.4	0.1	1.3	-0.2	0.4	1.3	1.4
Diastolic blood pressure, automated reading	0.9	2.8	5.0	2.0	1.2	1.6	-1.5	-2.0	-1.8	-2.0	-2.2	1.7	-1.7	-1.2	-1.4	-1.3	-1.9	-1.0	0.4	-2.1	-1.7	-2.2	-1.0
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	3.2	-1.3	-0.9	-1.0	0.8	1.0	1.3	1.3	1.0	-0.9	-0.0	-0.7	1.2	0.9	0.8	1.3	-1.8	1.1	1.1	0.2	0.7
Worry (Nagel 2018)	0.8	1.6	5.2	-1.3	-0.6	-1.1	2.3	1.7	1.8	2.0	0.6	-0.5	0.4	-0.2	1.7	1.0	0.4	1.6	-1.0	1.4	1.6	0.4	0.6
Breast Cancer	0.8	2.0	4.5	-1.7	-2.0	-2.1	0.8	1.5	1.5	1.2	1.6	-1.7	0.5	0.4	1.3	1.4	1.6	1.6	-1.7	1.2	1.2	1.1	0.8
Type 2 Diabetes (T2D) (2018)	0.8	1.5	5.8	-0.9	-1.4	-1.0	1.3	1.6	2.0	1.9	0.7	-0.9	0.1	-0.8	0.8	1.0	0.8	1.0	-2.4	0.8	0.9	0.8	0.7
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	3.2	1.1	1.2	1.1	-0.3	-0.1	-0.3	-0.3	-1.5	1.7	-1.2	0.1	-0.2	-1.1	-1.8	-0.7	1.6	-0.6	-0.3	-0.9	-0.9
Supplements: Zinc	0.8	0.9	2.7	0.5	0.6	0.5	-1.2	-0.9	-1.1	-1.1	-0.7	0.5	-1.0	-0.8	-1.3	-1.2	-0.6	-1.0	0.4	-1.0	-1.2	-0.9	-1.6
Average weekly fortified wine intake	0.8	0.9	4.0	-1.1	-0.8	-2.0	-0.1	0.3	0.2	0.3	1.8	-1.3	0.9	1.2	-0.1	0.3	1.3	-0.5	0.5	0.7	-0.1	1.1	0.8
Age when periods started (menarche)	0.8	2.0	3.2	-1.6	-1.3	-1.8	1.5	1.3	1.8	1.7	1.8	-1.4	0.1	1.5	1.2	1.3	1.5	1.3	-0.9	1.1	0.9	1.7	1.5
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.7	7.7	-1.8	-2.8	-1.6	0.7	0.5	0.8	0.5	1.7	-1.9	-0.3	-0.5	0.2	0.9	1.9	1.3	-2.3	0.8	0.3	0.8	-0.1
Medication: Ventolin 100micrograms inhaler	0.8	1.0	3.5	0.6	1.2	1.0	0.1	0.0	-0.4	-0.6	-1.2	1.2	-1.9	-1.0	-0.2	-0.9	-1.3	-0.2	0.6	-0.9	-0.4	-1.5	-1.6
Emphysema/chronic bronchitis	0.8	0.9	2.5	-0.5	-0.8	0.1	0.6	1.1	1.5	1.5	0.3	-0.3	-0.2	-1.6	1.3	0.8	0.2	1.2	-1.2	0.8	1.2	-0.7	0.5
Overall health rating	0.8	1.8	12.2	1.2	1.0	1.0	-0.7	-1.1	-0.2	-0.3	-1.6	1.1	-1.1	-3.5	-0.5	-0.7	-1.3	-0.4	-0.7	-1.3	-0.8	-2.6	-0.8
Chest pain or discomfort	0.8	1.1	5.5	-0.9	-0.7	-0.5	0.5	0.9	1.4	1.0	0.1	-0.2	-1.0	-2.4	1.1	0.5	0.1	1.5	-2.1	0.6	1.0	-0.9	-0.2
Illnesses of siblings: Diabetes	0.8	1.0	6.5	-1.1	-2.0	-1.0	0.2	-0.2	-0.1	-0.1	0.8	-1.2	-0.8	-0.7	-0.0	0.6	1.1	1.3	-2.5	0.7	0.4	0.2	0.4
Handedness (chirality/laterality): Left-handed	0.8	0.9	1.6	-0.7	-0.9	-0.9	0.3	1.0	1.1	1.0	0.9	-0.8	1.0	0.8	1.2	1.1	1.0	1.1	-0.6	1.1	1.3	1.3	0.3
Loneliness, isolation	0.8	1.1	3.2	-0.9	-0.8	-0.6	1.0	1.6	1.8	1.7	0.6	-0.5	-0.3	0.5	1.2	0.7	0.5	1.4	-1.0	1.2	1.3	1.1	-0.2
Medication: Bendroflumethiazide	0.8	1.2	3.8	0.3	0.3	-0.1	-1.4	-1.8	-1.4	-1.3	-0.1	-0.1	-0.4	-2.0	-1.5	-0.9	-0.1	-1.3	-0.3	-0.9	-1.4	-1.5	-0.8
Alzheimer’s Disease (including proxy)	0.7	1.1	2.5	-1.3	-1.5	-1.3	0.8	0.1	0.4	0.4	1.3	-1.6	0.4	-0.4	0.5	1.1	1.5	1.1	-1.5	1.1	0.8	0.7	0.9
Mean Putamen Volume	0.7	0.8	1.6	1.2	1.3	0.8	-0.3	-0.9	-0.7	-0.3	-1.1	1.1	-0.5	-0.6	-0.8	-1.0	-1.2	-1.1	1.2	-1.0	-0.9	-1.0	0.0
Cardiovascular Disease	0.7	2.5	12.6	0.2	0.4	0.5	-1.9	-2.2	-1.5	-1.9	-0.6	0.4	-1.7	-3.5	-1.6	-1.2	-0.6	-0.9	-0.7	-1.3	-1.7	-2.8	-0.9
Frequency of depressed mood in last 2 weeks	0.7	0.9	2.2	-1.2	-1.0	-1.0	0.8	0.0	0.9	0.9	0.9	-0.9	0.5	-0.5	1.1	1.0	0.9	1.2	-1.2	1.5	1.4	0.3	0.5
Maternal smoking around birth	0.7	1.0	3.0	0.2	0.9	-0.0	-0.8	-1.0	-0.5	-0.9	-0.4	0.5	-1.5	-1.5	-1.2	-1.2	-0.8	-0.7	-0.6	-0.8	-1.1	-1.7	-1.7
Heart attack	0.7	0.9	4.8	0.1	-0.6	0.0	-1.1	-1.0	-0.4	-0.6	-0.2	-0.2	-1.3	-2.2	-1.1	-0.6	-0.1	-0.3	-1.4	-0.7	-0.9	-1.5	-0.8
Diabetes (self-reported)	0.7	1.1	4.7	-0.7	-0.6	-0.6	1.1	1.5	1.9	1.7	0.5	-0.6	0.1	-0.9	0.6	0.7	0.5	0.8	-2.2	0.8	0.9	0.4	0.5
Weight	0.7	3.2	8.7	-0.8	-0.6	-1.4	2.1	3.0	2.7	2.6	1.0	-0.9	1.8	2.3	2.2	1.7	1.0	1.5	0.1	1.5	1.9	2.2	1.6
Alcohol intake versus 10 years previously	0.7	1.1	4.5	-0.6	-0.1	-0.7	2.1	1.8	1.4	1.6	0.6	-0.1	0.8	0.5	1.6	0.6	-0.2	0.6	0.9	1.0	1.2	0.0	1.0
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	2.0	1.2	0.9	1.4	-0.8	-0.8	-0.8	-0.8	-1.2	0.9	-0.4	-0.6	-0.8	-0.8	-0.9	-0.8	0.6	-0.9	-0.6	-0.8	-1.4
Depression (self-reported)	0.7	0.9	2.2	-0.8	-0.2	-0.7	0.9	1.5	1.3	1.3	0.2	-0.2	0.9	0.3	1.4	0.8	0.2	1.3	-0.8	1.2	1.4	0.2	0.7
Medication: Paracetamol	0.7	1.1	5.1	-1.2	-2.0	-1.4	0.5	0.6	0.9	0.5	1.1	-1.3	-0.9	-0.8	0.2	0.6	1.2	1.1	-2.3	0.3	0.1	0.3	0.0
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	8.5	0.3	0.0	0.4	1.2	1.7	1.0	1.1	-0.3	0.7	0.3	2.9	1.2	0.2	-0.5	0.4	1.6	0.4	0.9	1.6	0.1
Medication: Omeprazole	0.7	0.8	2.2	-1.0	-0.7	-0.8	0.6	0.9	1.2	1.1	0.9	-0.8	-0.1	-0.8	1.1	0.9	0.8	1.2	-1.5	0.8	0.9	0.1	0.8
Comparative height size at age 10	0.7	3.7	9.1	-0.5	0.2	-0.7	2.8	2.7	2.4	2.5	0.8	-0.7	1.8	3.0	2.4	2.0	1.0	1.8	0.6	1.2	1.8	2.8	2.5
Had major operations	0.7	0.8	3.0	-1.5	-1.1	-1.6	0.0	-0.4	0.3	0.1	1.3	-1.2	-0.3	-1.7	0.1	0.1	0.9	0.3	-1.1	0.8	0.2	-1.0	-0.4
Supplements: Vitamin C	0.7	0.8	2.0	-1.2	-1.2	-1.3	1.0	-0.0	0.0	0.4	1.4	-1.1	1.4	0.5	0.8	0.7	1.0	0.5	0.6	1.2	0.8	0.2	1.0
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	3.9	-1.1	-1.4	-0.9	0.3	0.3	1.2	0.9	0.7	-1.1	-0.3	-0.5	1.0	1.2	0.9	1.4	-2.0	1.0	1.1	0.6	1.2
Medication: Gliclazide	0.7	0.8	2.4	-0.8	-0.8	-1.2	0.7	0.7	1.0	1.3	0.8	-1.0	0.7	-0.6	0.5	0.8	0.9	0.5	-1.6	0.9	0.8	0.5	0.3
Medication: Atorvastatin	0.7	0.9	4.2	-1.1	-1.2	-0.6	0.2	-0.2	0.1	0.0	0.5	-0.9	0.1	-1.9	0.5	0.8	0.9	1.4	-2.1	1.0	0.9	-0.6	0.6
Vascular/heart problems diagnosed by doctor	0.7	2.0	13.1	-0.2	-0.1	-0.5	1.6	1.1	0.3	0.7	0.6	-0.3	2.2	3.6	1.3	1.0	0.5	0.5	1.5	1.3	1.5	2.5	1.3
Neuroticism (Nagel 2018)	0.6	1.5	4.6	-1.0	-0.4	-0.4	1.6	2.1	2.1	2.1	0.2	-0.1	-0.3	-0.8	1.6	0.8	0.0	1.7	-1.4	1.1	1.5	0.0	0.2
Verbal and Numeric Reasoning (VNR)	0.6	1.4	7.4	1.2	1.1	1.5	0.2	1.1	0.2	0.3	-1.3	1.5	-0.7	2.7	0.3	-0.5	-1.2	-0.1	2.2	-0.6	0.1	1.5	-0.8
Prostate Cancer	0.6	0.8	1.9	-0.7	-1.1	-0.2	0.7	1.2	1.2	1.0	0.6	-0.8	0.5	-0.7	1.0	1.1	0.7	1.0	-1.4	0.7	0.9	-0.0	0.7
Trunk fat percentage	0.6	2.3	6.8	1.0	-0.3	0.4	-1.6	-0.1	-1.0	-1.3	-0.9	0.8	-2.6	-1.4	-2.1	-1.9	-1.0	-1.5	-0.2	-2.0	-2.3	-1.5	-2.3
Impedance of leg (left)	0.6	2.7	11.1	-0.2	-1.3	0.3	-1.7	-1.8	-2.0	-2.2	0.2	-0.5	-1.8	-3.3	-2.2	-1.2	0.3	-0.8	-1.7	-1.4	-2.1	-2.2	-1.4
Qualifications: None of the above	0.6	1.3	5.5	-1.5	-2.0	-1.2	0.3	0.8	1.1	0.8	1.0	-1.1	-1.0	-1.5	0.7	0.6	0.8	1.4	-2.3	0.5	0.4	-0.8	0.2
Allergy	0.6	1.5	3.1	1.2	1.6	0.8	-0.9	-1.8	-1.5	-1.4	-1.1	1.1	0.3	-0.4	-1.1	-1.1	-1.3	-1.6	1.7	-1.1	-1.1	-1.4	-0.3
Medication: Blood pressure	0.6	1.1	5.7	-1.2	-0.8	-1.2	-0.8	-0.5	0.0	-0.2	1.3	-1.4	-0.6	-2.4	-0.8	0.2	1.3	0.1	-2.2	0.2	-0.6	-0.6	0.3
Mean time to correctly identify matches	0.6	1.2	3.6	1.1	0.7	0.5	-0.7	-1.6	-1.7	-1.3	-0.6	0.8	0.3	0.5	-1.1	-1.0	-0.8	-1.7	1.9	-1.1	-1.4	-0.9	0.2
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	5.5	0.2	0.5	0.2	-0.7	-1.0	-1.0	-0.9	-0.2	0.1	0.4	-2.4	-1.0	-0.8	-0.2	-0.8	-0.2	-0.3	-0.7	-1.2	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	5.8	-0.9	-0.9	-0.2	0.0	-0.3	-0.5	-0.2	0.6	-0.8	-0.1	-2.4	0.7	0.5	0.7	0.8	-0.4	0.5	0.6	-1.4	0.3
Mood swings	0.6	1.1	4.4	-0.8	-0.3	-0.5	1.3	1.5	2.1	1.6	0.3	-0.1	-0.3	-0.7	1.4	0.6	0.0	1.4	-0.9	1.0	1.4	-0.1	-0.4
Commuting to job workplace: Walk	0.6	0.6	2.3	0.9	1.5	1.0	-1.1	0.0	-0.1	-0.5	-1.1	1.0	-0.8	1.1	-0.4	-0.5	-0.9	-0.3	0.2	-0.8	-0.5	0.7	-0.5
Miserableness	0.6	1.0	3.3	-0.7	-0.7	-0.7	1.3	1.5	1.4	1.2	0.3	-0.5	-0.0	-0.3	0.9	0.8	0.5	1.4	-1.8	1.0	1.2	0.6	0.2
Medication: Lisinopril	0.6	0.7	3.8	-0.2	0.3	-0.0	0.6	1.1	1.4	1.3	-0.0	-0.1	0.5	2.0	0.7	0.7	0.2	0.8	-0.6	0.3	0.6	1.5	0.8
Age started oral contraceptive pill	0.6	0.8	1.8	1.3	1.2	1.0	-0.0	-0.2	-0.4	-0.2	-1.3	1.3	-0.7	-0.3	-0.6	-1.1	-1.4	-0.9	0.7	-0.8	-0.6	-0.7	-1.1
Myopia	0.6	0.8	2.8	0.4	1.1	0.7	0.7	1.4	1.1	1.1	-0.8	0.8	0.5	1.7	1.0	0.7	-0.6	0.5	0.3	-0.0	0.8	1.2	1.1
Basal cell carcinoma (self-reported)	0.6	0.7	2.3	1.0	1.2	1.5	-0.4	-0.6	-0.7	-0.8	-1.4	1.2	-0.7	0.1	-0.5	-0.6	-1.1	-0.3	0.4	-1.1	-0.6	-0.6	-0.6
Heart attack/myocardial infarction (self-reported)	0.6	0.7	4.3	-0.2	-0.9	-0.3	-1.0	-0.9	-0.2	-0.5	0.1	-0.5	-1.0	-2.1	-0.9	-0.4	0.2	-0.1	-1.5	-0.4	-0.7	-1.3	-0.6
Depression (Nagel 2018)	0.5	0.7	2.2	-0.9	-0.7	-0.4	1.1	0.4	1.0	1.1	0.3	-0.3	0.4	-0.4	1.5	0.8	0.2	1.3	-0.5	1.1	1.4	-0.1	0.7
Reaction Time	0.5	0.9	3.7	0.9	0.5	0.0	-0.7	-1.6	-1.5	-1.2	-0.1	0.4	1.0	0.4	-1.0	-0.8	-0.4	-1.7	1.9	-0.4	-1.0	-0.6	0.2
HbA1C	0.5	0.6	4.6	-0.4	0.2	-1.0	0.0	0.2	0.2	0.1	1.0	0.2	-0.1	0.0	-0.7	-1.2	-0.3	-1.4	2.1	0.1	-0.9	0.0	0.0
Lupus	0.5	0.7	2.3	0.9	0.9	0.7	-1.5	-1.4	-1.2	-1.2	-0.7	0.7	0.5	0.7	-0.7	-0.6	-0.7	-0.6	1.0	-0.6	-0.7	-0.2	0.0
Rheumatoid Arthritis	0.5	0.7	3.1	0.0	0.0	-0.5	1.2	0.0	0.0	0.0	0.0	-0.6	0.0	0.0	1.3	0.0	0.7	1.0	0.0	1.6	1.6	1.8	0.0
Blood White Count	0.5	3.6	31.2	0.1	-0.5	-0.7	-1.2	-1.2	-0.9	-1.1	0.1	-0.3	-2.0	-5.6	-1.8	-1.2	0.0	-0.9	-2.0	-1.3	-1.7	-3.5	-2.1
Lung FVC	0.5	2.5	4.9	-1.7	-0.8	-2.2	0.8	0.7	0.5	0.6	2.0	-2.0	2.2	1.5	1.4	1.8	2.2	1.1	-0.2	2.1	1.7	2.0	1.6
Impedance of leg (right)	0.5	2.4	11.7	-0.4	-1.6	0.0	-1.2	-1.6	-1.7	-2.0	0.4	-0.9	-1.6	-3.4	-1.9	-0.8	0.6	-0.5	-2.1	-1.2	-1.8	-2.1	-0.9
Relative age voice broke	0.5	0.7	2.3	-0.3	-0.2	-0.3	1.0	1.5	1.3	1.2	0.3	0.1	1.0	1.2	1.0	0.4	-0.1	0.4	0.7	1.0	1.1	0.7	0.1
Serious illness, injury or assault to yourself	0.5	0.6	2.5	-0.6	-1.6	-0.9	-0.6	-0.7	-0.8	-1.0	0.7	-0.8	-1.3	-1.2	-0.5	-0.3	0.5	-0.1	0.1	-0.3	-0.9	-0.9	0.1
Stomach or abdominal pain in last month	0.5	0.7	3.1	-0.2	-0.2	-0.2	1.8	0.9	0.9	1.3	0.1	-0.2	0.5	-1.0	1.1	0.9	0.3	0.9	-0.5	0.6	1.0	-0.3	1.0
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	3.0	0.9	0.8	0.6	-0.4	-0.6	-1.1	-0.7	-0.2	0.6	-0.4	-0.1	-0.7	-0.9	-0.5	-1.3	1.7	-0.6	-0.8	-0.4	-0.6
Medication: Atenolol	0.5	0.6	2.1	-1.4	-1.2	-1.5	-0.0	0.2	0.2	0.0	1.3	-1.0	0.0	-1.3	-0.2	0.1	0.7	0.3	-0.7	0.5	-0.3	-1.0	0.9
Mouth/teeth dental problems	0.5	0.7	3.0	0.7	1.4	1.2	0.6	1.3	0.4	0.7	-0.8	1.0	0.5	1.7	0.3	-0.3	-0.7	-0.1	1.1	-0.1	0.3	0.9	-0.2
Illnesses of siblings	0.5	0.6	2.9	0.5	1.1	0.5	0.2	1.2	0.7	0.5	-0.6	0.7	0.4	1.7	0.6	0.2	-0.5	-0.1	1.6	-0.2	0.3	1.2	0.4
Number of live births	0.5	0.7	3.2	-0.6	-0.7	-0.2	0.1	1.8	1.6	1.3	0.1	-0.1	-0.6	-0.4	1.0	0.5	0.0	1.0	-1.0	0.5	0.8	0.2	0.1
Lung cancer (father)	0.5	0.6	2.8	0.1	0.2	-0.2	-1.0	-1.7	-1.5	-1.1	0.2	-0.2	0.7	0.6	-0.9	-0.6	0.1	-0.9	0.6	-0.3	-0.8	-0.1	-0.2
Birth weight of first child	0.5	0.8	2.9	-0.5	-1.0	-0.5	0.9	1.2	0.8	1.0	0.4	-0.7	1.0	-1.0	1.2	1.4	0.6	0.7	-0.5	0.6	1.0	-0.1	1.7
High blood pressure (siblings)	0.5	0.7	4.1	-0.6	-1.2	-0.4	0.2	-0.6	-0.1	-0.1	0.6	-0.8	-0.9	-2.0	-0.2	0.1	0.5	0.5	-1.7	0.2	-0.1	-1.2	-0.0
Exposure to tobacco smoke outside home	0.5	0.7	3.3	-1.0	-1.4	-1.2	0.1	0.3	0.8	0.5	1.0	-1.2	-0.0	0.1	0.3	0.5	1.1	0.8	-1.8	0.7	0.4	0.7	-0.1
Wheeze or whistling in the chest in last year	0.5	0.9	4.7	-0.4	-0.6	-0.1	0.6	1.1	1.3	1.2	-0.2	-0.1	-1.0	-2.2	1.2	0.5	-0.1	1.2	-1.4	0.3	0.8	-1.2	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	3.3	-0.4	0.0	-0.2	0.5	1.8	1.4	1.3	0.3	-0.2	-1.4	0.4	0.4	0.4	0.3	0.7	-0.9	-0.2	0.0	0.9	-0.1
Age at first live birth	0.5	0.8	2.3	0.7	0.5	0.9	-0.8	-1.3	-1.0	-1.2	-0.5	0.4	-1.5	0.4	-1.4	-0.6	-0.2	-0.9	0.6	-1.3	-1.5	0.1	-0.1
Mouth/teeth dental problems: Loose teeth	0.5	0.6	2.0	-1.3	-1.4	-0.9	-0.2	-0.6	-0.5	-0.7	1.2	-1.2	-0.1	-0.8	-0.2	0.2	1.2	0.3	-0.7	0.5	-0.1	-0.2	-0.1
Medication for pain relief, constipation, heartburn	0.5	0.9	2.6	1.1	1.4	0.9	-0.9	-1.1	-1.3	-1.0	-0.9	0.8	0.3	1.2	-0.6	-0.5	-0.8	-1.0	1.6	-0.8	-0.7	0.2	0.3
Alcohol intake frequency.	0.5	1.1	4.4	-1.0	-1.1	-1.0	1.0	2.1	1.9	1.7	0.5	-0.4	-0.7	-0.1	1.2	0.6	0.4	1.3	-1.2	0.4	0.7	0.4	0.2
Ever had bowel cancer screening	0.5	0.6	1.8	0.9	1.1	1.0	0.1	0.1	-0.1	0.2	-1.1	1.3	-0.5	0.3	0.1	-0.6	-1.4	-0.3	1.3	-0.7	-0.3	-0.6	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	2.2	0.2	0.3	0.8	0.5	1.5	0.7	0.8	-0.5	0.8	-1.3	1.2	0.3	-0.2	-0.7	0.2	0.5	-0.2	0.1	0.7	-0.2
Number of self-reported non-cancer illnesses	0.5	0.9	3.3	0.7	0.7	1.1	-0.7	-0.6	-0.4	-0.6	-1.0	0.9	-1.1	-1.8	-0.6	-1.0	-0.9	-0.4	-0.3	-0.8	-0.6	-1.4	-1.4
Medication: Paracetamol	0.5	0.8	3.9	-0.6	-1.4	-1.1	0.3	1.3	1.3	0.8	0.6	-0.8	-1.1	-0.7	0.2	0.4	0.7	0.9	-2.0	-0.0	-0.0	0.4	-0.2
Risk taking	0.5	0.7	2.3	0.8	0.1	0.8	-0.4	-0.0	-1.1	-1.0	-0.6	0.7	-1.5	-0.7	-0.6	-0.9	-0.5	-0.6	1.0	-1.0	-0.9	-0.9	-1.2
Depressed Affect (Nagel 2018)	0.4	0.8	3.6	-0.4	-0.2	-0.1	0.6	1.9	1.7	1.4	-0.1	0.2	-0.8	-1.0	0.8	0.2	-0.2	1.1	-1.2	0.5	0.8	-0.2	-0.4
Intelligence (Savage-Jansen 2018)	0.4	1.3	8.6	0.8	0.9	0.9	0.2	0.9	0.3	0.4	-1.0	1.4	-0.8	2.9	0.3	-0.4	-1.0	-0.0	2.2	-0.4	0.1	1.7	-0.3
Crohns Disease (2017)	0.4	0.8	3.1	-0.8	-0.5	-0.8	1.8	1.0	1.0	1.0	0.7	-0.7	0.7	-0.6	1.3	0.8	0.6	0.9	-0.1	1.1	1.2	-0.3	0.7
Neuroticism (2016)	0.4	0.6	3.8	-0.2	-0.0	-0.2	1.1	1.6	1.9	1.6	-0.1	0.3	0.1	0.2	0.4	-0.0	-0.3	0.1	-0.4	0.3	0.4	0.4	-0.6
Blood Red Count	0.4	3.7	7.0	2.0	1.0	2.3	-1.9	-2.4	-1.8	-1.8	-1.4	1.1	-2.1	-2.6	-2.3	-1.8	-1.3	-1.8	-0.0	-2.3	-2.4	-2.4	-2.0
Respiratory disease	0.4	0.9	3.7	-0.6	-0.6	0.1	0.7	1.4	1.6	1.1	0.0	0.0	-1.8	-1.1	0.5	0.1	0.0	1.2	-1.9	-0.3	0.2	-0.1	-1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.6	-1.0	-1.2	-0.9	0.2	-0.1	0.6	0.7	0.7	-0.7	-0.0	-0.6	0.8	0.6	0.6	0.9	-0.9	0.9	0.8	-0.0	0.4
Hair/balding pattern: Pattern 2	0.4	0.5	4.8	-0.2	-0.6	0.5	0.5	1.1	0.8	0.5	-0.2	0.3	-0.4	2.2	0.4	-0.0	-0.3	0.6	0.3	0.1	0.2	1.1	-0.2
Pain all over the body in last month	0.4	0.5	1.4	-0.4	-0.1	-0.6	0.6	0.9	1.2	1.1	0.2	-0.2	-0.2	0.7	0.8	0.6	0.3	1.1	-0.9	0.4	0.7	0.8	0.2
Fluid intelligence score	0.4	0.7	2.6	0.1	0.5	0.5	1.1	1.3	0.9	1.1	-0.3	0.4	0.4	1.6	1.0	0.5	-0.2	0.5	0.9	0.4	0.9	1.6	0.6
Father’s age at death	0.4	0.5	3.0	-0.0	0.0	0.7	0.2	1.3	1.5	1.0	-0.3	0.3	-1.7	0.1	0.4	0.2	-0.3	0.7	-0.6	-0.7	-0.2	0.2	0.2
Length of working week for main job	0.4	0.4	1.4	-0.2	0.2	-0.5	0.4	0.7	0.6	0.7	0.4	-0.2	0.9	1.2	0.9	0.6	0.4	0.5	0.7	0.7	0.8	1.0	0.4
Loud music exposure frequency	0.4	0.5	1.6	-1.1	-0.9	-1.3	0.2	-0.1	0.4	0.4	0.8	-0.9	-0.1	-0.1	0.5	0.4	0.7	0.7	-1.3	0.8	0.6	0.4	-0.2
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	2.9	1.2	1.1	1.7	-0.5	-0.2	-0.2	-0.2	-0.8	1.1	-1.6	0.6	-0.5	-0.8	-1.0	-0.7	0.8	-0.9	-0.6	0.1	-1.1
Medication: Amlodipine	0.4	0.6	5.5	0.1	0.5	-0.2	-0.3	-0.4	-0.3	-0.2	0.0	-0.1	-0.8	-2.3	-0.8	-0.5	0.0	-0.5	-0.6	-0.4	-0.7	-1.2	-0.9
Body fat percentage	0.4	1.8	5.3	0.7	-0.6	0.1	-1.5	-0.1	-0.8	-1.1	-0.6	0.4	-2.3	-1.7	-1.8	-1.6	-0.7	-1.2	-0.5	-1.6	-2.0	-1.6	-2.1
Worry too long after embarrassment	0.4	0.7	2.4	-0.7	0.1	-0.6	1.3	1.0	1.3	1.5	0.2	-0.2	-0.0	-0.4	1.0	0.6	0.1	0.9	-1.1	0.8	1.1	0.4	0.3
Number of children fathered	0.4	0.4	2.8	0.3	0.1	0.3	-0.4	-0.2	-0.1	-0.3	-0.6	0.5	-1.4	-1.0	-0.4	-0.6	-0.6	-0.0	-0.3	-0.4	-0.2	-0.8	-1.7
Shortness of breath walking on level ground	0.4	0.4	2.0	0.2	1.2	0.4	-0.1	-0.1	0.4	0.2	-0.5	0.6	0.0	-1.4	0.9	0.1	-0.6	0.5	0.5	0.5	0.9	-1.0	-0.6
Eye problems/disorders: None of the above	0.4	0.5	1.8	0.8	1.1	0.8	-0.3	-0.0	-0.2	-0.1	-0.5	0.8	-0.4	-0.3	-0.5	-0.7	-0.7	-1.0	1.3	-0.6	-0.5	-0.3	-0.8
Medication: Seretide 50 evohaler	0.4	0.4	2.6	0.4	0.3	0.7	-0.5	-0.1	0.1	-0.1	-0.7	0.6	-1.3	-0.7	-0.5	-0.7	-0.6	-0.3	-0.3	-0.6	-0.4	-0.2	-1.6
Smoking status: Previous	0.4	0.5	1.4	0.5	0.0	0.8	-1.0	-0.8	-0.6	-0.8	-0.6	0.5	-0.5	-0.8	-0.7	-0.5	-0.6	-0.5	0.6	-1.0	-1.0	-1.2	0.5
Arm fat percentage (left)	0.4	1.5	4.8	0.8	-0.2	0.2	-1.4	-0.1	-0.7	-1.1	-0.8	0.7	-2.2	-0.9	-1.6	-1.6	-0.9	-1.2	-0.0	-1.4	-1.7	-1.1	-2.2
Average weekly red wine intake	0.4	0.6	1.7	-0.5	-0.2	-0.8	1.3	1.0	0.9	1.1	0.5	-0.4	1.3	0.9	0.8	0.7	0.5	0.4	0.2	0.9	1.0	0.6	0.7
Medication: Aspirin	0.4	0.5	1.2	0.7	0.3	0.5	-0.7	-0.2	0.1	-0.2	-0.8	0.6	-0.9	-1.1	-0.8	-0.7	-0.7	-0.5	-0.5	-0.8	-0.7	-1.0	-0.9
Tinnitus: Yes, now most or all of the time	0.4	0.4	2.6	-0.2	-0.5	-0.1	0.1	-0.3	-0.3	-0.4	-0.2	0.3	-1.1	-1.6	0.3	-0.4	-0.4	0.4	0.4	0.3	0.4	-1.5	-0.8
Commuting to job workplace: Public transport	0.4	0.5	2.6	0.8	0.8	0.9	0.1	0.1	-0.0	0.0	-1.0	0.9	0.2	1.6	0.4	0.2	-0.7	-0.2	1.4	-0.5	0.1	0.4	0.8
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.9	-0.6	0.2	-1.0	0.9	-0.4	-0.5	0.0	0.5	-0.3	1.4	0.6	0.6	0.5	0.2	-0.0	1.3	0.8	0.5	-0.2	1.3
Average weekly beer plus cider intake	0.4	0.6	1.4	0.7	0.8	1.0	-0.9	-0.0	-0.5	-0.8	-1.0	1.2	-1.0	0.1	-0.4	-0.9	-1.1	-0.3	1.0	-0.7	-0.5	-0.5	-0.9
Alcohol drinker status: Previous	0.4	0.5	1.5	0.9	0.8	0.9	-0.5	0.6	0.4	0.4	-1.2	1.0	-0.9	0.4	-0.0	-0.4	-1.0	-0.1	0.1	-1.1	-0.5	-0.1	-0.2
Alzheimer’s Disease (in mother)	0.3	0.4	1.3	-0.7	-1.1	-0.9	0.5	0.2	0.4	0.4	0.8	-0.8	-0.6	0.4	-0.0	0.3	0.8	0.4	-0.4	0.4	0.1	0.9	0.2
Triglycerides	0.3	0.6	2.8	-1.7	-1.0	-1.7	0.9	1.2	0.0	0.0	0.0	-1.5	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Blood Platelet Count	0.3	3.6	10.9	1.3	1.4	0.9	-1.7	-0.5	-1.3	-1.5	-1.8	1.9	-3.3	-1.7	-1.8	-2.3	-1.9	-1.5	0.7	-2.2	-2.0	-2.3	-3.2
Chronotype (morning person)	0.3	0.7	3.6	-0.7	-0.4	-0.5	-0.4	-0.1	-0.4	-0.5	1.2	-1.2	-0.4	-1.9	-0.8	-0.1	1.3	-0.2	-1.4	0.1	-0.6	-0.5	-0.6
Average weekly spirits intake	0.3	0.4	4.6	0.3	0.2	-0.0	0.1	0.3	0.1	0.2	-0.1	0.0	-0.1	2.1	0.3	0.2	0.0	-0.1	1.0	0.1	0.2	1.0	0.5
Hearing difficulty/problems: Yes	0.3	0.4	1.1	-0.8	0.0	-0.6	0.4	1.1	0.9	0.8	0.3	-0.0	-0.9	0.1	0.9	0.2	-0.0	0.7	0.1	0.8	0.9	0.0	-0.7
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	1.9	-0.1	-0.6	0.1	-0.8	-0.7	0.2	0.1	-0.1	-0.3	0.4	-1.3	-0.1	0.2	0.1	0.2	-1.4	0.4	0.3	-0.4	0.1
Medication for hormone replacement therapy	0.3	0.3	1.9	-0.1	-0.6	-0.0	0.9	-0.0	0.2	0.6	-0.1	-0.0	0.0	-1.4	0.6	0.3	-0.2	0.2	0.0	0.3	0.5	-1.1	0.4
Fed-up feelings	0.3	0.6	1.5	0.3	0.6	0.3	-1.1	-0.3	-0.5	-0.7	-0.6	0.6	-0.8	-1.2	-0.9	-1.0	-0.8	-0.5	-0.2	-0.4	-0.6	-1.2	-1.2
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.8	3.3	-0.9	-1.8	-0.7	0.1	-0.5	-0.1	-0.4	0.8	-1.1	-0.9	-1.6	-0.5	0.1	1.0	0.5	-1.8	-0.0	-0.4	-0.4	-0.8
High blood pressure	0.3	1.0	6.0	-0.1	0.2	0.2	-0.8	-0.2	0.2	-0.1	-0.4	0.3	-2.0	-2.4	-0.6	-0.7	-0.5	-0.0	-1.2	-1.0	-1.0	-1.7	-0.8
Hayfever, allergic rhinitis or eczema	0.3	0.7	3.6	-0.9	-1.9	-1.0	0.0	0.5	0.0	0.1	1.2	-1.3	0.1	0.1	0.0	0.5	1.3	0.5	-0.9	0.7	0.2	0.9	0.3
Multivitamins +/- minerals	0.3	0.4	1.8	-0.5	-0.4	-0.4	0.6	1.4	1.0	1.0	0.5	-0.4	-0.3	0.8	0.5	0.3	0.3	0.7	-0.7	0.4	0.3	0.7	0.1
Medication: Simvastatin	0.3	0.4	3.0	0.5	0.5	0.1	-0.1	-0.6	-0.6	-0.3	-0.3	0.3	0.4	-1.7	-0.3	-0.4	-0.4	-0.8	0.2	-0.3	-0.3	-1.4	-0.3
Arm fat percentage (right)	0.3	1.3	4.5	0.7	-0.3	0.1	-1.3	-0.1	-0.6	-1.0	-0.6	0.6	-2.1	-0.9	-1.5	-1.5	-0.7	-1.0	-0.1	-1.3	-1.6	-1.0	-2.1
Noisy workplace	0.3	0.4	1.8	-0.8	-0.9	-0.3	-0.1	0.1	0.5	0.6	0.7	-0.7	0.2	-1.3	0.4	0.3	0.6	0.5	-1.2	0.7	0.6	-0.6	-0.3
Qualifications: A levels/AS levels or equivalent	0.3	0.6	4.2	0.9	1.0	0.7	0.4	-0.1	-0.7	-0.4	-0.4	0.5	1.3	1.3	-0.2	-0.0	-0.3	-0.9	2.1	0.2	0.2	0.6	0.3
Medication: Cholesterol lowering	0.3	0.5	2.4	-0.6	-0.2	-0.6	0.2	-0.7	0.1	0.2	0.4	-0.7	0.8	-1.6	0.2	0.6	0.5	0.3	-1.2	0.5	0.4	-0.8	0.9
Breastfed as a baby	0.3	0.4	2.1	0.7	1.2	0.9	0.7	0.2	-0.1	0.2	-0.7	0.9	-0.0	0.8	0.5	-0.1	-0.8	-0.1	1.5	-0.1	0.3	-0.1	0.2
Pulse wave reflection index	0.3	0.4	1.7	-0.8	-1.1	-0.7	0.6	0.4	0.9	0.7	0.3	-0.2	-0.3	-1.0	0.4	0.2	-0.0	0.5	-1.3	0.2	0.2	-0.6	0.5
Gout (self-reported)	0.3	0.4	0.8	0.6	0.4	0.5	-0.9	-0.9	-0.7	-0.3	-0.8	0.6	0.6	-0.2	-0.8	-0.7	-0.7	-0.6	-0.4	-0.3	-0.4	-0.3	-0.5
Leg fat percentage (right)	0.3	0.9	4.9	-0.4	-1.6	-1.0	-0.5	0.3	0.2	-0.1	0.5	-0.7	-1.4	-2.2	-0.6	-0.4	0.4	0.0	-1.6	-0.5	-0.8	-1.4	-0.9
Pulse rate, automated reading	0.3	0.9	3.1	0.4	-0.0	-0.1	-0.6	-1.8	-1.3	-1.5	-0.5	-0.0	-0.7	-1.4	-1.1	-0.4	-0.0	-0.3	-1.1	-0.9	-1.0	-1.3	-0.8
Suffer from ‘nerves’	0.3	0.5	2.1	-1.1	-0.8	-1.3	0.2	0.2	0.4	0.6	0.7	-0.7	-0.3	-1.3	0.1	0.2	0.5	0.6	-1.4	0.4	0.1	-0.5	0.1
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	2.8	0.3	1.0	0.5	0.9	0.4	-0.3	0.3	-0.3	0.7	0.5	1.7	0.3	-0.1	-0.6	-0.0	0.9	0.1	0.2	0.5	0.4
Medication: Aspirin	0.3	0.3	0.7	0.6	0.4	0.6	-0.5	-0.1	0.1	-0.1	-0.7	0.6	-0.8	-0.8	-0.6	-0.6	-0.7	-0.4	-0.3	-0.7	-0.6	-0.8	-0.8
Hypertension (Self-reported)	0.3	0.9	6.1	-0.1	0.2	0.2	-0.8	-0.2	0.1	-0.2	-0.3	0.2	-1.7	-2.5	-0.7	-0.7	-0.4	-0.2	-1.1	-0.9	-1.0	-1.7	-0.8
Eye problems/disorders: Cataract	0.3	0.3	1.7	-0.6	-1.1	-0.7	-0.1	-0.1	0.3	0.1	0.3	-0.6	-0.1	-0.3	0.4	0.6	0.4	0.9	-1.3	0.2	0.2	-0.1	0.5
Mineral and other dietary supplements	0.3	0.4	2.9	0.4	-0.4	0.6	-1.0	-0.0	0.4	-0.1	-0.1	-0.2	-0.9	-0.5	-0.8	-0.3	0.3	-0.1	-1.7	-0.6	-0.5	0.7	-1.2
Asthma (self-reported)	0.3	0.6	3.8	0.3	0.4	0.9	-0.1	0.4	0.5	0.0	-0.8	0.6	-1.9	-0.7	-0.2	-0.4	-0.5	0.4	-0.9	-1.0	-0.5	-0.3	-1.4
Wears glasses or contact lenses	0.3	0.3	1.7	0.6	0.6	0.4	0.2	-0.4	-0.3	-0.1	-0.6	0.1	0.4	-1.1	-0.5	0.1	-0.1	-0.0	-1.3	-0.6	-0.4	-0.7	-0.1
Medication: Blood pressure	0.3	0.5	1.2	1.0	0.5	0.8	-0.3	0.2	-0.0	0.0	-1.1	1.0	-0.6	-0.4	-0.5	-0.8	-1.0	-0.6	0.3	-1.1	-0.8	-0.6	-0.8
Illnesses of father: High blood pressure	0.3	0.3	1.6	0.3	-0.0	-0.1	-0.5	-1.2	-1.2	-0.9	-0.2	0.2	0.3	-0.4	-0.2	-0.2	-0.3	-0.3	0.3	-0.3	-0.4	-1.1	0.2
Alcohol drinker status: Never	0.3	0.4	2.7	-0.9	-1.7	-0.7	-0.4	-0.0	-0.1	-0.1	0.6	-0.5	-0.9	-0.3	0.1	-0.0	0.4	0.5	-0.8	0.3	0.1	-0.0	-0.5
Ever smoked	0.3	0.4	2.0	0.4	0.5	0.6	0.5	0.4	-0.0	0.2	-0.7	0.7	1.0	1.1	1.0	0.4	-0.5	0.5	1.4	0.2	0.7	-0.1	0.7
Number of operations (self-reported)	0.3	0.4	1.2	-0.8	-0.8	-0.4	1.0	0.6	1.1	0.9	0.3	-0.3	-0.8	0.0	0.8	0.3	0.2	0.9	-0.6	0.3	0.5	0.2	-0.4
Fractured/broken bones in last 5 years	0.3	0.4	2.1	-0.0	0.1	0.3	1.0	0.4	0.0	0.4	-0.1	0.2	1.4	-0.1	1.0	0.5	-0.3	0.2	0.9	0.6	0.9	-0.2	0.8
Pain experienced in last month	0.3	0.4	1.7	0.7	0.9	-0.0	-1.0	-0.9	-1.3	-1.1	-0.2	0.2	0.1	0.7	-0.8	-0.3	0.1	-0.7	0.6	-0.5	-0.5	0.5	-0.1
Heart disease (siblings)	0.3	0.4	1.8	-0.9	-0.8	-0.8	0.7	-0.1	0.6	0.5	0.7	-0.7	0.0	0.3	0.3	0.4	0.5	0.7	-1.3	0.7	0.6	0.4	-0.3
Irritable Bowel Disease (IBD)	0.2	0.5	3.3	-0.2	-0.7	-0.2	1.8	0.7	0.5	0.5	0.2	-0.4	0.7	-0.5	1.0	0.6	0.4	0.8	0.1	0.6	0.8	-0.4	0.2
Ovarian Cancer	0.2	0.3	1.2	-0.5	-0.8	-0.4	0.2	0.0	-0.1	0.2	0.6	-0.7	0.4	-1.0	0.1	0.5	0.6	0.3	-1.1	0.4	0.1	-0.4	0.9
Age at First Birth	0.2	0.3	1.3	0.3	0.4	0.5	-1.0	-0.4	-0.9	-0.7	-0.7	0.4	0.5	0.0	0.6	0.3	0.0	0.1	1.1	0.4	0.3	0.0	0.7
Hypothyroidism (self reported)	0.2	0.4	2.5	0.9	0.9	1.6	-0.1	-0.5	-0.2	-0.2	-0.7	0.9	-0.6	0.4	-0.2	-0.5	-0.9	-0.5	0.6	-0.5	-0.3	-0.1	-0.4
Tanning	0.2	2.4	7.2	1.2	0.6	1.3	-1.4	-2.1	-1.9	-2.0	-1.1	0.7	-1.4	-2.7	-1.7	-1.1	-0.9	-1.2	-0.5	-1.7	-1.7	-2.5	-1.1
Hand grip strength (left)	0.2	0.4	4.3	-0.1	0.2	-0.3	0.2	-0.5	-0.3	-0.1	0.3	-0.5	2.1	-1.0	0.2	0.5	0.5	-0.1	0.3	0.8	0.6	-0.2	0.8
Relative age of first facial hair	0.2	0.3	1.1	0.5	0.6	0.7	0.5	0.4	-0.1	-0.1	-0.7	0.9	0.5	0.2	0.2	-0.3	-0.9	-0.4	1.0	0.1	0.3	-0.7	-0.7
Vitamin and mineral supplements	0.2	0.3	1.1	0.7	0.9	1.0	-0.4	0.1	0.2	-0.2	-1.0	0.9	-0.4	0.2	-0.3	-0.4	-0.7	-0.4	-0.0	-0.6	-0.2	0.3	-0.6
Townsend deprivation index at recruitment	0.2	0.3	0.9	0.4	-0.1	0.4	-0.5	-0.9	-0.5	-0.7	-0.4	0.5	-0.6	-0.6	-0.3	-0.6	-0.5	-0.4	0.4	-0.6	-0.6	-1.0	-0.4
Medication: Levothyroxine sodium	0.2	0.4	1.1	0.8	0.8	0.8	-0.2	0.6	0.6	0.6	-0.3	0.6	-1.1	0.3	-0.2	-0.5	-0.5	-0.6	0.4	-0.5	-0.3	0.3	-0.9
Number of incorrect matches in round	0.2	0.4	1.3	-0.0	0.0	0.4	0.6	1.1	1.0	0.7	-0.6	0.6	-0.8	-0.6	0.5	-0.1	-0.7	0.5	-0.7	0.0	0.4	-0.8	-0.3
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	1.3	0.6	0.9	0.4	-0.7	-0.3	-1.2	-0.6	-0.3	0.2	0.3	0.4	-0.4	-0.2	-0.1	-0.5	1.0	-0.4	-0.4	0.1	0.3
Hip circumference	0.2	0.7	3.5	0.2	0.1	-0.3	1.1	1.9	1.3	1.3	0.0	0.1	0.1	1.7	1.0	0.4	-0.0	0.4	0.9	0.0	0.4	1.2	0.3
Time employed in main current job	0.2	0.2	1.2	-0.2	-0.1	-0.4	0.6	-0.2	-0.5	-0.1	0.3	-0.5	1.1	-0.0	0.3	0.5	0.5	0.1	0.3	0.5	0.4	-0.1	0.8
Hair/balding pattern: Pattern 3	0.2	0.2	2.4	-0.2	-0.7	0.2	0.3	-0.1	0.3	0.2	-0.1	-0.4	0.4	-0.5	0.2	0.6	0.4	0.5	-1.6	0.0	0.3	0.4	-0.0
Mouth/teeth dental problems: Dentures	0.2	0.4	2.3	0.1	-0.4	-0.2	-0.5	-0.1	-0.1	-0.1	0.0	0.1	-1.0	-1.5	-0.4	-0.6	-0.3	-0.6	0.1	-0.6	-0.7	-1.1	-0.8
Asthma	0.2	0.5	2.5	0.4	0.6	1.0	-0.1	0.4	0.5	0.1	-0.8	0.7	-1.6	-0.7	-0.1	-0.3	-0.6	0.3	-0.6	-1.0	-0.5	-0.4	-1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	1.1	0.2	0.5	0.5	0.7	0.7	1.0	0.9	-0.5	0.5	-0.6	0.7	0.4	-0.0	-0.5	0.4	-0.2	0.0	0.4	0.7	-0.3
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	1.1	-0.4	-0.2	-0.9	-1.1	-1.0	-0.5	-0.7	0.5	-0.6	0.2	0.2	-0.4	0.2	0.5	0.0	-0.8	0.5	0.0	0.3	0.4
Headache pain in last month	0.2	0.3	2.4	-0.3	-0.4	0.1	0.3	0.5	0.3	-0.0	0.1	0.1	-1.5	-1.1	-0.2	-0.6	-0.3	0.1	-0.3	-0.1	-0.3	-0.9	-0.8
Chronic bronchitis/emphysema (mother)	0.2	0.3	1.7	0.0	-0.1	-0.1	0.2	0.6	0.8	0.7	0.1	-0.2	1.3	-0.2	0.4	0.6	0.3	0.2	-0.8	0.1	0.3	0.1	0.7
Number of full brothers	0.2	0.2	1.0	0.2	0.3	0.4	0.5	-0.4	-0.2	-0.3	-0.4	0.3	-0.4	-1.0	-0.1	-0.3	-0.4	-0.0	-0.7	0.0	0.2	-0.6	-1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	2.6	0.2	0.0	-0.2	0.2	0.1	0.6	0.6	-0.3	0.2	-0.8	-1.6	0.1	-0.1	-0.4	0.3	-0.8	-0.1	0.0	-1.0	-0.1
Health satisfaction	0.2	0.2	0.6	-0.0	0.2	0.2	0.5	0.6	0.6	0.8	-0.5	0.5	-0.6	0.0	0.7	0.2	-0.6	0.7	-0.1	0.3	0.7	-0.0	-0.0
Medication: Allopurinol	0.2	0.3	0.7	0.6	0.9	0.7	-0.7	-0.8	-0.6	-0.3	-0.6	0.6	0.8	0.3	-0.5	-0.5	-0.6	-0.6	0.1	-0.0	-0.2	0.1	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.9	0.9	0.7	0.7	0.0	-0.1	-0.0	0.1	-0.5	0.3	0.9	0.3	0.1	0.3	-0.1	0.0	0.6	-0.3	0.1	0.2	0.4
Leg fat mass (right)	0.2	0.7	2.0	-0.7	-1.1	-1.4	0.8	1.4	1.2	1.0	0.8	-0.9	0.3	-0.3	0.7	0.6	0.7	0.7	-0.8	0.6	0.5	0.2	0.3
Number of full sisters	0.2	0.3	2.2	-0.4	-0.5	0.1	-0.8	0.4	0.4	0.0	0.5	-0.3	-1.5	0.4	-0.5	-0.4	0.2	-0.0	-0.7	-0.2	-0.6	0.6	-0.5
Family relationship satisfaction	0.2	0.3	0.9	0.7	0.9	0.5	-0.4	-0.8	-0.3	-0.1	-0.6	0.6	-0.5	0.4	-0.4	-0.5	-0.5	-0.5	0.5	-0.5	-0.4	0.3	-0.6
Illnesses of father: Heart disease	0.2	0.3	1.3	-0.4	-0.5	-0.8	1.1	-0.8	-0.1	0.1	0.4	-0.3	0.8	-0.5	0.6	0.5	0.2	0.5	-0.2	0.6	0.6	-0.7	0.4
Long-standing illness, disability or infirmity	0.2	0.3	1.1	-0.4	-0.5	-0.2	0.3	0.6	0.9	1.0	0.2	0.0	-0.7	-0.4	0.8	0.2	-0.2	0.6	-0.5	0.5	0.6	-0.2	0.4
Qualifications: nursing, teaching	0.2	0.2	1.5	0.3	0.2	0.2	-0.2	-0.1	-0.3	0.0	0.0	0.0	0.4	1.2	-0.2	0.1	0.2	-0.5	1.1	-0.1	-0.2	1.2	0.2
Medication for cholesterol	0.2	0.3	0.8	-0.7	0.2	-0.9	-0.0	-0.9	-0.6	-0.6	0.9	-0.7	0.4	-0.1	-0.1	0.3	0.8	0.1	-0.2	0.4	0.1	0.2	0.3
Back pain experienced in last month	0.2	0.3	1.8	-1.0	-1.3	-0.6	0.6	0.3	0.5	0.1	0.8	-0.6	-0.3	0.2	0.3	-0.1	0.4	0.4	-0.3	0.6	0.3	-0.1	-0.7
Hearing aid user	0.2	0.2	1.1	-0.1	0.4	0.1	0.1	0.2	0.0	0.0	0.1	0.4	-1.1	-0.4	-0.2	-0.6	-0.5	-0.4	0.6	0.2	-0.1	-0.9	-0.6
High cholesterol (Self-reported)	0.2	0.4	3.0	0.1	-0.0	0.1	-0.4	-0.9	-0.7	-0.6	-0.2	0.1	-0.1	-1.7	-0.6	-0.5	-0.3	-0.5	-0.5	-0.4	-0.6	-1.4	-0.3
Leg fat percentage (left)	0.2	0.9	4.5	-0.2	-1.3	-0.7	-0.9	0.3	0.0	-0.3	0.2	-0.4	-1.5	-2.1	-0.8	-0.7	0.1	-0.2	-1.2	-0.7	-1.0	-1.5	-1.2
Unable to work because of sickness or disability	0.2	0.2	1.3	-0.2	-0.8	0.2	-0.2	-0.5	-0.3	-0.2	0.1	-0.3	-0.0	-1.2	0.5	0.2	0.3	0.4	0.1	0.2	0.3	-0.9	0.0
Supplements: Calcium	0.2	0.2	0.8	0.4	-0.1	0.4	-0.5	-0.1	-0.4	-0.4	-0.3	0.3	-0.5	0.9	-0.5	-0.4	-0.3	-0.5	0.6	-0.4	-0.5	0.1	0.1
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.8	0.5	0.7	0.4	0.7	0.4	0.4	0.4	-0.4	0.7	-0.4	0.9	0.2	-0.3	-0.6	-0.3	0.8	-0.2	0.0	0.1	-0.1
Pack years of smoking	0.2	0.2	1.4	-0.2	-0.7	-0.2	0.0	-0.1	-0.3	-0.2	0.1	-0.3	-0.1	-1.2	-0.3	-0.2	0.3	0.2	-1.2	0.2	0.0	-0.6	-0.7
Bipolar Disorder (2018)	0.1	0.1	1.0	-0.4	-0.7	0.0	1.0	0.0	0.0	0.0	0.0	-0.4	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder or Schizophrenia	0.1	0.2	2.5	0.0	0.0	0.0	1.6	0.0	0.0	0.0	0.0	-1.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Schizophrenia (2018)	0.1	0.2	2.8	0.0	0.0	0.0	1.7	0.0	0.0	0.0	0.0	-1.1	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ulcerative Colitis (UC)	0.1	0.2	1.1	0.5	-0.3	0.9	1.0	0.1	-0.4	-0.4	-0.6	0.4	0.2	-0.2	0.2	-0.1	-0.3	0.2	0.7	-0.1	0.2	-0.4	-0.7
Body Mass Index (BMI) (2010)	0.1	0.1	1.3	0.0	0.0	-0.9	0.7	0.0	0.0	0.0	0.0	-1.1	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.1	0.1	2.3	0.0	0.0	0.0	-0.4	0.0	0.0	0.0	0.0	1.5	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
HDL Cholesterol	0.1	0.2	1.3	-0.6	-0.9	-0.2	1.2	0.5	0.0	0.0	0.0	-0.7	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
LDL Cholesterol	0.1	0.2	1.5	0.5	0.6	0.3	-1.0	-1.2	0.0	0.0	0.0	0.1	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Primary Biliary Cirrhosis	0.1	0.2	0.8	0.6	0.1	0.1	-0.1	0.4	0.0	-0.1	-0.2	0.2	-0.3	0.6	-0.5	0.0	-0.2	-0.6	0.5	-0.9	-0.9	0.1	0.0
Schizophrenia (2014)	0.1	0.1	1.8	0.0	0.0	0.0	1.3	0.0	0.0	0.0	0.0	-0.7	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Heel T-Score	0.1	1.1	5.4	-0.9	-1.1	-1.0	1.1	-0.1	1.0	1.1	0.9	-1.2	-0.3	-1.8	0.3	0.7	1.3	1.1	-2.3	0.7	0.6	0.5	-0.6
Allergy or Eczema	0.1	0.4	2.5	-0.6	-1.6	-0.7	0.6	0.6	-0.2	-0.1	0.8	-0.8	-0.1	0.7	-0.2	0.1	0.9	0.2	-0.4	0.3	-0.1	0.8	0.1
Pack years adult smoking proportion	0.1	0.2	0.9	-0.1	-0.6	-0.2	0.1	-0.3	-0.4	-0.3	-0.0	-0.2	0.1	-1.0	-0.3	-0.2	0.2	0.2	-0.9	0.2	0.1	-0.5	-0.7
Hand grip strength (right)	0.1	0.1	0.6	-0.2	0.3	-0.1	-0.1	-0.7	-0.3	-0.2	0.4	-0.4	0.7	-0.7	-0.4	0.0	0.3	-0.3	-0.0	0.5	0.1	-0.3	-0.1
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.4	-0.2	-0.7	-0.4	0.3	-0.1	0.4	0.4	0.1	-0.2	0.1	-0.5	0.4	0.3	0.0	0.3	-0.6	0.4	0.4	-0.3	0.3
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.9	0.4	0.9	0.2	-0.1	0.1	0.1	0.0	-0.5	0.4	-0.1	0.3	-0.1	-0.2	-0.3	-0.1	0.0	-0.2	-0.1	0.0	0.1
Supplements: Glucosamine	0.1	0.1	0.4	-0.5	-0.2	-0.2	-0.0	0.4	0.5	0.5	0.1	0.1	-0.3	0.6	0.4	0.1	-0.2	0.4	0.4	0.1	0.2	0.2	0.2
High blood pressure (mother)	0.1	0.1	0.6	-0.4	-0.2	-0.5	0.8	-0.0	0.5	0.6	0.4	-0.3	0.1	0.0	0.6	0.4	0.3	0.4	-0.2	0.3	0.3	0.2	0.3
Body mass index (BMI)	0.1	0.3	1.3	-0.2	-0.7	-0.9	0.2	1.1	1.0	0.8	0.3	-0.3	-0.2	-0.3	0.5	0.2	0.2	0.3	-0.3	0.3	0.3	-0.1	-0.2
Trunk fat mass	0.1	0.3	1.5	0.2	-0.6	-0.4	-0.1	1.2	0.5	0.3	-0.0	0.0	-1.0	-0.1	-0.4	-0.5	-0.1	-0.2	-0.3	-0.6	-0.7	-0.0	-0.7
Past tobacco smoking	0.1	0.2	1.5	-0.1	0.2	-0.4	-0.3	-0.4	-0.3	-0.3	0.3	-0.3	-0.6	-0.2	-0.7	-0.5	0.2	-0.5	-0.8	0.1	-0.3	0.4	-1.2
Medication: Ramipril	0.1	0.2	0.6	0.1	0.2	-0.2	-0.6	-0.3	-0.4	-0.3	-0.0	0.0	-0.6	0.5	-0.7	-0.2	0.0	-0.3	-0.4	-0.5	-0.8	0.4	0.4
Arm fat mass (right)	0.1	0.3	1.9	-0.3	-0.8	-1.0	0.3	1.4	0.9	0.8	0.4	-0.3	-0.3	0.3	0.3	0.1	0.3	0.3	-0.3	0.2	0.1	0.4	-0.3
Hair/balding pattern: Pattern 4	0.1	0.1	0.9	-0.2	0.1	-0.5	-0.5	-0.4	-0.1	-0.1	0.3	-0.4	-0.3	-1.0	-0.2	-0.0	0.4	0.1	-0.3	0.3	0.0	-0.2	-0.0
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	1.1	0.6	0.4	0.3	-0.3	-0.5	-0.4	-0.4	-0.1	0.1	0.4	0.1	-0.5	-0.1	-0.0	-0.8	1.0	-0.2	-0.3	0.2	0.2
Blood clot in the leg (DVT)	0.1	0.2	0.9	0.2	0.4	0.1	0.8	0.4	0.5	0.5	-0.1	0.4	-0.2	0.9	0.4	-0.0	-0.3	-0.1	0.6	0.0	0.2	0.2	0.0
Glaucoma (self-reported)	0.1	0.1	0.8	-0.0	0.3	0.0	0.9	0.3	-0.3	-0.3	-0.3	0.3	-0.5	-0.1	0.0	-0.2	-0.4	0.1	-0.1	0.2	0.2	-0.4	-0.2
Comparative body size at age 10	0.1	0.4	1.1	0.9	1.0	0.4	-0.1	0.2	0.1	0.1	-0.6	0.8	-0.2	-0.9	-0.3	-0.6	-0.9	-1.0	0.6	-0.5	-0.4	-1.0	-0.2
Whole body fat mass	0.1	0.2	2.0	-0.0	-0.7	-0.6	0.2	1.4	0.8	0.6	0.1	-0.1	-0.6	0.1	0.0	-0.2	0.0	0.1	-0.3	-0.2	-0.3	0.1	-0.5
Friendships satisfaction	0.1	0.1	0.7	0.1	-0.1	-0.2	-0.1	-0.5	0.1	-0.0	-0.2	0.0	-0.8	0.7	-0.2	0.2	0.1	0.2	-0.5	-0.2	-0.2	0.8	0.3
Breast cancer (self-reported)	0.1	0.1	0.3	0.5	0.2	0.5	0.4	0.3	0.1	0.4	-0.5	0.3	-0.5	-0.5	0.4	0.1	-0.3	0.3	0.0	-0.1	0.3	-0.2	-0.4
Osteoporosis (self-reported)	0.1	0.2	0.4	0.2	-0.5	0.7	0.5	0.4	0.1	0.4	-0.5	0.2	0.0	-0.4	0.6	0.4	-0.1	0.6	-0.5	0.0	0.5	-0.1	0.6
Ever taken oral contraceptive pill	0.1	0.1	0.5	0.3	0.7	0.4	0.1	-0.2	-0.4	-0.3	-0.5	0.4	-0.4	-0.2	-0.2	-0.2	-0.3	0.0	-0.1	-0.1	0.0	-0.1	-0.6
Eye problems/disorders: Glaucoma	0.1	0.1	0.8	-0.3	0.0	-0.2	0.8	0.9	0.1	0.1	0.1	0.2	-0.7	0.0	0.2	-0.2	-0.2	0.3	-0.1	0.4	0.3	-0.3	-0.3
Cholesterol lowering medication	0.1	0.1	0.6	-0.0	-0.3	-0.2	-0.2	0.8	0.5	0.4	-0.1	0.0	-0.4	-0.2	0.2	0.0	0.0	0.4	-0.7	0.0	0.2	-0.0	-0.5
Leg fat mass (left)	0.1	0.5	2.3	-0.6	-1.0	-1.1	0.7	1.5	1.2	1.1	0.6	-0.6	0.2	-0.1	0.7	0.4	0.5	0.6	-0.6	0.5	0.5	0.1	0.1
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ulcerative Colitis	0.0	0.0	0.8	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.9	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
BMI	0.0	0.2	1.2	0.0	-0.1	-0.5	0.4	0.7	0.4	0.3	0.1	0.1	-0.3	-1.1	0.0	-0.3	-0.1	-0.3	0.1	-0.1	-0.1	-0.6	-0.6
Hair Pigment	0.0	0.8	2.0	-0.3	0.2	0.0	0.6	1.4	1.3	1.4	0.2	-0.1	1.3	0.7	1.3	0.9	0.3	0.7	-0.0	1.1	1.4	0.9	0.8
Waist circumference	0.0	0.2	1.3	0.1	-0.5	-0.6	-0.0	1.1	0.8	0.7	0.1	-0.1	-0.4	-0.5	0.1	0.0	0.1	-0.1	-0.2	-0.2	-0.2	-0.2	0.0
Arm fat mass (left)	0.0	0.2	1.3	0.1	-0.4	-0.7	0.0	1.2	0.7	0.5	0.1	-0.0	-0.4	0.4	0.0	-0.2	-0.1	-0.0	-0.0	-0.1	-0.1	0.3	-0.6

Hub : Genes

TPSB2

Models

Trait associations