TWAS hub - YY1AP1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.3530	0.0590	0.0e+00	0.515	0.485	0.515	0.518	0.513	5.5e-73	5.1e-67	7.3e-73	1.4e-73	1.4e-72
2	GTEx	Testis	0.5430	0.0980	3.7e-12	0.341	NA	0.343	NA	0.383	7.7e-16	NA	5.8e-16	NA	4.7e-18
3	TCGA	Breast Invasive Carcinoma	0.0269	0.0212	4.1e-04	0.008	0.010	0.011	NA	0.010	7.6e-03	2.7e-03	1.6e-03	NA	3.7e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Crohns Disease (2012)	13.4	21.5	22.4	4.5	-4.7	-4.7
Crohns Disease (2017)	12.9	28.3	31.8	5.1	-5.2	-5.6
Breast Cancer	11.6	27.8	34.8	-4.4	5.9	5.4
Medication: Ramipril	11.0	14.1	15.5	3.9	-3.7	-3.6
Irritable Bowel Disease (IBD)	8.7	20.8	22.4	4.7	-4.3	-4.7
Pain experienced in last month	8.4	14.1	18.5	2.9	-3.9	-4.3
Medication: Ibuprofen (e.g. Nurofen)	7.1	9.0	10.7	-2.5	3.1	3.3
Medication: Ibuprofen	6.2	7.4	8.8	-2.5	2.7	3.0
Impedance of leg (left)	5.9	28.8	44.6	2.8	-5.8	-6.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	5.8	6.9	7.7	2.8	-2.8	-2.4
Impedance of leg (right)	5.7	27.5	42.2	2.8	-5.7	-6.5
Impedance of whole body	5.0	25.5	44.8	0.8	-5.6	-6.7
Tinnitus: Yes, but not now, but have in the past	4.4	4.7	5.5	-2.3	2.2	2.0
Number of full brothers	4.1	5.1	6.2	2.5	-2.5	-1.8
Mean Putamen Volume	3.9	4.4	5.7	2.4	-2.2	-1.7
Hayfever, allergic rhinitis or eczema	3.9	8.4	10.8	2.5	-3.3	-2.8
Bipolar Disorder (2018)	3.8	6.0	7.6	2.8	-2.2	-2.3
Current tobacco smoking	3.7	6.0	6.9	2.6	-2.6	-2.1
Allergy	3.7	8.5	10.1	-2.6	2.9	3.2
Impedance of arm (left)	3.7	17.3	31.1	-0.9	-4.5	-5.6
Breast cancer (self-reported)	3.6	4.3	6.5	2.5	-2.0	-1.5
Asthma (self-reported)	3.6	7.2	8.8	2.7	-2.4	-3.0
Bipolar Disorder or Schizophrenia	3.5	8.6	10.5	3.2	-2.9	-2.7
Pain all over the body in last month	3.5	3.8	4.2	-2.0	1.8	1.9
Pulse wave Arterial Stiffness index	3.5	4.1	5.9	1.7	-1.8	-2.4
Medication for cholesterol, blood pressure or diabetes	3.5	5.8	6.8	-2.5	2.6	2.1
Heart disease (mother)	3.5	4.2	5.3	-2.3	1.7	2.1
Lung FVC	3.3	16.7	24.0	-2.5	4.5	4.9
High blood pressure (mother)	3.3	4.7	5.1	-2.1	2.1	2.3
Impedance of arm (right)	3.3	15.4	26.8	-1.2	-4.2	-5.2
Comparative body size at age 10	3.3	9.2	11.5	-2.6	3.0	3.4
Medication: Blood pressure	3.3	5.8	6.9	2.5	-2.6	-2.1
Schizophrenia (2014)	3.2	7.0	8.2	2.8	-2.9	-2.2
Allergy or Eczema	3.2	8.3	11.4	2.6	-3.4	-2.6
Asthma	3.1	6.1	8.2	2.4	-2.1	-2.9
Pulse wave peak to peak time	3.1	3.7	5.1	-1.8	1.7	2.2
Leg pain on walking	3.1	3.9	7.1	-1.1	1.9	2.7
Time employed in main current job	3.0	3.5	5.1	-2.3	1.8	1.5
Shortness of breath walking on level ground	3.0	3.6	4.6	-1.8	1.7	2.1
Frequency of depressed mood in last 2 weeks	2.8	3.9	4.7	2.0	-2.2	-1.8
Financial difficulties in last 2 years	2.8	3.7	6.4	-1.5	1.6	2.5
Guilty feelings	2.8	4.2	7.1	2.7	-1.9	-1.4
Respiratory disease	2.7	5.9	6.4	2.5	-2.4	-2.4
Hair/balding pattern: Pattern 2	2.7	3.5	5.0	2.2	-1.9	-1.4
Myopia	2.6	3.8	5.3	1.8	-1.7	-2.3
Neck or shoulder pain in last month	2.5	3.5	5.7	-0.6	2.1	2.4
Nervous feelings	2.4	4.4	5.3	-2.3	2.0	2.0
Loud music exposure frequency	2.4	2.6	3.8	-1.6	1.1	1.9
Smoking status: Current	2.4	3.7	4.7	1.9	-2.2	-1.7
Severe depression (siblings)	2.3	2.5	3.5	1.2	-1.9	-1.6
Medication: Paracetamol	2.3	3.8	3.8	-2.0	1.9	1.9
Seen a psychiatrist for nerves, anxiety, tension or depression	2.3	2.9	3.7	1.6	-1.9	-1.6
Migraine (self-reported)	2.3	2.8	3.5	-1.9	1.4	1.7
Birth weight	2.2	4.8	7.2	-2.7	2.2	1.6
Health satisfaction	2.2	2.8	3.7	-1.4	1.7	1.9
Osteoarthritis (self-reported)	2.2	2.8	4.6	-1.3	1.5	2.1
Alcohol drinker status: Previous	2.2	2.5	3.6	1.9	-1.5	-1.3
Ulcerative Colitis (UC)	2.1	3.9	5.3	2.3	-1.6	-1.9
Pulse wave reflection index	2.1	2.6	2.8	1.6	-1.7	-1.6
Medication for pain relief, constipation, heartburn	2.1	3.6	6.6	1.5	-1.5	-2.6
Body Mass Index (BMI) (2010)	2.0	2.7	5.1	-1.8	2.2	0.0
Smoking Status	2.0	4.7	5.1	2.1	-2.3	-2.1
Worrier / anxious feelings	2.0	3.8	6.5	-2.5	1.7	1.5
Family relationship satisfaction	2.0	2.5	3.1	1.4	-1.8	-1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.0	2.4	3.3	-1.8	1.4	1.3
Medication: Paracetamol	2.0	3.1	4.1	-2.0	1.7	1.6
Medication: Atorvastatin	2.0	2.5	3.6	1.9	-1.5	-1.3
Risk taking	2.0	2.9	3.4	1.6	-1.7	-1.8
Miserableness	1.9	3.3	3.6	1.8	-1.8	-1.9
Depression (Nagel 2018)	1.8	2.7	3.9	2.0	-1.7	-1.2
Qualifications: CSEs or equivalent	1.8	2.3	3.0	1.7	-1.7	-1.1
Breastfed as a baby	1.8	2.3	3.1	1.8	-1.4	-1.4
Hypothyroidism/myxoedema (self-reported)	1.8	3.5	5.2	-1.2	1.9	2.3
Hypertension (Self-reported)	1.8	5.1	6.2	2.5	-2.4	-1.9
Waist Hip Ratio (WHR)	1.7	7.7	12.7	0.4	-3.6	-3.2
Supplements: Zinc	1.7	1.8	2.8	-0.8	1.7	1.5
Reason for reducing amount of alcohol drunk: Health precaution	1.7	2.0	2.9	1.0	-1.5	-1.7
Chest pain or discomfort	1.7	2.5	3.0	1.7	-1.6	-1.3
Average weekly beer plus cider intake	1.7	2.4	2.9	-1.6	1.7	1.3
Schizophrenia (2018)	1.6	3.3	3.8	1.9	-1.9	-1.6
Cardiovascular Disease	1.6	5.2	6.2	2.5	-2.5	-1.8
Tanning	1.6	19.7	28.2	5.3	-4.6	-3.1
Ever used hormone-replacement therapy (HRT)	1.6	2.0	2.6	-1.1	1.6	1.6
Exposure to tobacco smoke at home	1.6	1.7	2.6	-1.1	1.2	1.6
Tense / ‘highly strung’	1.6	2.7	3.4	1.5	-1.5	-1.9
Leg fat-free mass (right)	1.6	8.6	14.3	-1.3	3.1	3.8
Leg predicted mass (right)	1.6	8.8	14.4	-1.4	3.1	3.8
Maternal smoking around birth	1.5	2.2	2.9	1.4	-1.7	-1.3
Leg predicted mass (left)	1.5	7.9	13.3	-1.2	3.0	3.6
Had other major operations	1.5	1.8	2.8	1.5	-1.7	-0.6
Hayfever/allergic rhinitis (self-reported)	1.5	2.0	2.5	1.2	-1.5	-1.6
Trunk fat-free mass	1.5	8.3	14.7	-0.1	3.2	3.8
Trunk predicted mass	1.5	8.3	14.7	-0.0	3.2	3.8
Whole body water mass	1.5	8.3	14.8	-0.4	3.2	3.9
Depressed Affect (Nagel 2018)	1.4	2.9	3.5	1.5	-1.7	-1.9
Rheumatoid Arthritis	1.4	1.9	3.1	-1.3	1.8	1.0
Leg fat-free mass (left)	1.4	7.3	12.5	-1.1	2.9	3.5
Whole body fat-free mass	1.4	8.2	14.6	-0.4	3.1	3.8
Arm fat-free mass (left)	1.4	7.0	12.8	0.2	2.8	3.6
Reaction Time	1.3	2.4	3.0	1.5	-1.7	-1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.3	1.8	2.7	1.6	-1.3	-1.0
Body mass index (BMI)	1.3	5.5	11.3	-0.6	2.2	3.4
Hair/balding pattern: Pattern 3	1.3	2.0	4.0	-2.0	1.1	0.8
Qualifications: College or University degree	1.3	4.0	5.2	-2.1	2.3	1.6
Financial situation satisfaction	1.3	1.6	2.1	1.4	-1.3	-1.0
Arm predicted mass (left)	1.3	6.6	12.2	0.3	2.7	3.5
Medication: Gliclazide	1.2	1.4	2.6	0.4	-1.1	-1.6
Illnesses of father: None of the above (group 1)	1.2	1.5	1.7	1.1	-1.3	-1.3
Basal metabolic rate	1.2	6.9	12.6	-0.4	2.8	3.5
Vascular/heart problems diagnosed by doctor	1.2	3.4	4.7	-2.2	1.8	1.4
HDL Cholesterol	1.1	1.8	2.7	-1.6	1.6	0.0
BMI	1.1	6.2	12.0	-1.2	2.2	3.5
Eye problems/disorders: None of the above	1.1	1.3	2.6	-0.8	0.8	1.6
Number of full sisters	1.1	1.3	2.8	1.7	-1.0	0.4
Knee pain experienced in last month	1.1	1.7	3.0	-0.5	1.4	1.7
Loneliness, isolation	1.1	1.5	1.9	1.2	-1.1	-1.4
Number of self-reported non-cancer illnesses	1.1	2.0	2.7	1.3	-1.6	-1.2
Commuting to job workplace: Public transport	1.1	1.4	1.5	-1.2	1.2	1.1
Irritability	1.1	1.8	3.6	0.6	-1.2	-1.9
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	1.9	1.2	-1.4	-0.9
Medication: Co-codamol	1.0	1.2	2.3	-0.6	0.9	1.5
High blood pressure	1.0	2.8	4.1	2.0	-1.7	-1.3
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.6	2.1	1.4	-1.2	-1.0
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.4	3.1	1.4	-1.8	-1.4
Diabetes (self-reported)	1.0	1.6	2.6	0.2	-1.5	-1.6
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.3	4.9	-1.2	1.9	2.2
Age at first live birth	1.0	1.8	2.2	-1.5	1.4	1.1
Supplements: Glucosamine	0.9	1.2	2.5	-0.4	0.9	1.6
Arm fat-free mass (right)	0.9	4.5	8.1	0.8	2.2	2.9
Wheeze or whistling in the chest in last year	0.9	1.7	3.0	1.7	-1.2	-0.8
Mean time to correctly identify matches	0.9	1.8	2.6	1.4	-1.6	-0.8
Arm predicted mass (right)	0.9	4.4	7.7	0.9	2.2	2.8
Alcohol intake frequency.	0.9	2.0	3.8	-1.1	1.1	1.9
Fractured/broken bones in last 5 years	0.9	1.2	1.6	1.3	-0.7	-1.2
Alzheimer’s Disease (in mother)	0.8	0.9	1.1	0.9	-1.1	-0.9
Alzheimer’s Disease (in father)	0.8	0.8	1.3	-0.7	1.1	0.9
Hair Pigment	0.8	23.5	33.6	4.5	-4.0	-5.8
Diabetes (mother)	0.8	1.0	1.9	0.6	-1.4	-0.9
Relative age voice broke	0.8	1.2	2.3	1.5	-1.0	-0.7
Chronic bronchitis/emphysema (father)	0.8	0.9	1.5	-0.4	1.2	1.1
Forced vital capacity (FVC)	0.8	3.1	4.5	-0.7	2.0	2.1
Forced expiratory volume in 1-second (FEV1)	0.8	2.6	4.7	-0.8	1.6	2.2
Forced vital capacity (FVC), Best measure	0.8	3.0	4.5	-0.8	2.0	2.1
Qualifications: NVQ or HND or HNC or equivalent	0.8	0.9	1.2	1.1	-1.1	-0.7
Long-standing illness, disability or infirmity	0.8	1.2	2.4	1.1	-1.5	-0.5
Diabetes diagnosed by doctor	0.8	1.3	2.5	0.2	-1.2	-1.6
Back pain experienced in last month	0.8	1.2	2.7	-0.2	0.9	1.6
Hearing aid user	0.8	0.9	1.5	-0.4	0.9	1.2
Illnesses of father: High blood pressure	0.8	1.1	1.9	-0.1	1.4	1.1
Diastolic blood pressure, automated reading	0.8	2.4	2.6	-1.6	1.6	1.4
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	1.3	1.1	-0.7	-1.1
Heart disease (siblings)	0.8	1.0	1.8	-0.5	0.9	1.3
LDL Cholesterol	0.7	1.1	1.8	1.4	-1.2	0.0
Medication: Levothyroxine sodium	0.7	1.2	1.8	-0.8	1.1	1.3
Qualifications: None of the above	0.7	1.5	2.7	-0.9	1.0	1.6
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	2.6	1.6	-0.9	-0.2
Mouth/teeth dental problems: Dentures	0.7	1.2	2.1	0.6	-1.5	-1.0
Depression (self-reported)	0.7	0.9	1.4	0.6	-1.2	-0.9
Arm fat mass (right)	0.7	2.9	5.7	-1.1	1.3	2.4
Blood clot in the leg (DVT)	0.7	0.9	1.2	1.0	-0.6	-1.1
Overall health rating	0.7	1.6	2.9	-1.0	0.9	1.7
Supplements: Vitamin C	0.7	0.9	1.1	-0.8	1.0	1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	1.1	0.8	-0.9	-1.0
Wears glasses or contact lenses	0.7	0.8	1.2	-0.0	-1.1	-1.1
Medication: Blood pressure	0.7	1.2	1.9	1.4	-1.0	-0.9
Ever had prostate specific antigen (PSA) test	0.7	0.9	1.0	-0.9	0.8	1.0
Basal cell carcinoma (self-reported)	0.7	0.8	1.0	-1.0	0.9	0.7
Worry (Nagel 2018)	0.6	1.2	2.7	-1.7	0.7	0.6
Age at First Birth	0.6	0.9	2.0	0.9	-1.4	0.0
Fasting Glucose	0.6	0.7	0.9	0.9	-0.7	-1.0
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	0.8	-0.9	0.8	0.7
Fed-up feelings	0.6	1.0	1.7	0.8	-0.9	-1.3
Stomach or abdominal pain in last month	0.6	0.8	0.9	-0.9	0.8	0.9
Exposure to tobacco smoke outside home	0.6	0.7	1.0	0.9	-1.0	-0.6
Medication: Aspirin	0.6	0.8	1.6	0.8	-1.3	-0.5
Average weekly red wine intake	0.6	0.8	1.4	0.4	-1.0	-1.2
Eye problems/disorders: Cataract	0.6	0.7	0.9	0.9	-0.7	-0.8
Medication: Aspirin	0.6	0.8	1.6	0.9	-1.2	-0.3
Ever depressed for a whole week	0.6	0.7	1.1	0.9	-1.1	-0.5
Coronary Artery Disease (CAD)	0.5	0.6	1.4	-0.5	1.2	0.0
Primary Biliary Cirrhosis	0.5	0.7	0.8	0.9	-0.8	-0.8
Ulcerative Colitis	0.5	0.8	1.2	1.1	-0.6	-0.9
Blood Eosinophil Count	0.5	3.6	6.8	-2.6	1.4	1.4
Type 2 Diabetes (T2D) (2018)	0.5	0.9	2.1	-0.1	-0.7	-1.4
Relative age of first facial hair	0.5	1.1	1.5	1.2	-1.1	-0.6
Age when periods started (menarche)	0.5	1.2	2.1	1.1	-1.4	-0.6
Hair/balding pattern: Pattern 4	0.5	1.2	1.4	-1.0	1.2	1.1
Number of children fathered	0.5	0.6	1.2	1.1	-0.7	-0.3
Mouth/teeth dental problems: Loose teeth	0.5	0.6	0.8	0.7	-0.9	-0.6
Illnesses of siblings: Diabetes	0.5	0.6	0.8	-0.6	0.8	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	2.4	-0.2	0.8	1.5
Arm fat mass (left)	0.5	2.1	4.5	-0.9	1.0	2.1
High cholesterol (Self-reported)	0.5	0.9	1.9	1.4	-0.8	-0.3
Age started oral contraceptive pill	0.5	0.6	1.4	-1.2	0.7	0.1
Neuroticism (Nagel 2018)	0.4	0.9	1.1	0.7	-1.1	-1.0
Verbal and Numeric Reasoning (VNR)	0.4	1.1	1.5	-0.7	1.2	1.1
Ovarian Cancer	0.4	0.6	0.7	0.9	-0.6	-0.8
Heel T-Score	0.4	3.0	4.0	1.8	-2.0	-1.3
Height	0.4	7.4	8.5	2.5	-2.7	-2.9
Systolic Blood Pressure	0.4	1.8	2.6	1.0	-1.6	-1.4
Hypothyroidism (self reported)	0.4	0.9	1.7	0.0	0.9	1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	1.4	1.0	-1.2	-0.6
Serious illness, injury or assault to yourself	0.4	0.5	1.4	0.0	-1.2	-0.4
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	0.7	-0.8	0.5	0.7
Hearing difficulty/problems with background noise	0.4	0.6	1.2	-0.5	0.7	1.1
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.1	0.1	0.6	1.1
Mouth/teeth dental problems	0.4	0.6	1.1	-0.3	1.1	0.7
Weight	0.4	1.8	4.1	0.0	1.2	2.0
Arm fat percentage (right)	0.4	1.7	2.5	-1.6	0.6	1.5
Hip circumference	0.4	1.9	3.8	0.2	1.4	1.9
Father’s age at death	0.4	0.5	0.9	-1.0	0.8	-0.1
Peak expiratory flow (PEF)	0.4	0.9	2.1	-0.5	0.5	1.4
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.1	1.0	-0.5	-0.3
Commuting to job workplace: Walk	0.4	0.4	0.9	-1.0	0.6	0.1
Medication for cholesterol	0.4	0.5	0.7	-0.9	0.8	0.5
Medication: Bendroflumethiazide	0.4	0.6	1.0	1.0	-0.5	-0.7
Major Depression (MDD)	0.3	0.4	1.0	0.4	-0.4	-1.0
Bipolar Disorder (2011)	0.3	0.3	0.5	0.6	-0.7	0.0
HbA1C	0.3	0.3	0.9	0.0	0.0	0.9
Blood White Count	0.3	2.0	3.3	1.0	-1.8	-1.3
Neuroticism	0.3	0.7	1.1	-0.0	-0.9	-1.0
Diabetes (father)	0.3	0.4	0.6	0.8	-0.5	-0.5
Trunk fat percentage	0.3	1.3	2.7	-0.3	-1.6	-1.0
Medication: Atenolol	0.3	0.4	0.4	0.6	-0.6	-0.6
Pulse rate	0.3	0.5	0.7	0.8	-0.1	-0.9
Qualifications: A levels/AS levels or equivalent	0.3	0.6	1.0	-1.0	1.0	-0.1
Medication: Cholesterol lowering	0.3	0.4	0.7	0.7	-0.8	-0.2
Illnesses of mother	0.3	0.3	0.7	0.8	-0.2	-0.4
Standing height	0.3	3.4	5.5	1.1	-1.9	-2.3
Birth weight of first child	0.3	0.5	0.8	-0.8	-0.2	-0.9
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.1	0.1	-0.4	-1.1
Headache pain in last month	0.3	0.6	1.5	-0.2	0.5	1.2
Glaucoma (self-reported)	0.3	0.3	0.5	0.1	-0.6	-0.7
Angina (self-reported)	0.3	0.4	0.7	-0.5	0.5	0.9
Medication: Omeprazole	0.3	0.4	1.0	-0.3	0.1	1.0
Pulse rate, automated reading	0.3	0.9	1.3	-1.1	1.0	0.6
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	0.8	0.5	-0.1	-0.9
Arm fat percentage (left)	0.3	1.0	1.7	-1.3	0.3	1.2
Mood swings	0.3	0.5	0.8	0.3	-0.9	-0.9
Mineral and other dietary supplements	0.3	0.3	0.8	-0.4	-0.3	-0.9
Average weekly champagne plus white wine intake	0.3	0.4	0.9	-0.9	0.5	0.3
Ever taken oral contraceptive pill	0.3	0.4	0.5	0.4	-0.7	-0.7
Alcohol drinker status: Never	0.3	0.4	0.6	-0.6	0.7	0.5
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.8	-0.5	0.0	0.9
Supplements: Calcium	0.3	0.3	0.4	0.3	-0.6	-0.7
Schizophrenia vs Biploar Disorder	0.2	0.2	0.5	-0.3	0.2	0.7
Lupus	0.2	0.3	0.9	0.2	0.2	0.9
Triglycerides	0.2	0.4	0.6	0.8	-0.7	0.0
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.4	0.6	-0.5	0.0
Blood Platelet Count	0.2	2.6	3.8	0.7	-1.9	-1.9
Blood Red Count	0.2	1.8	2.0	-1.2	1.3	1.4
Lung FEV1/FVC ratio	0.2	0.8	1.7	-1.3	-0.4	0.8
Number of treatments/medications taken	0.2	0.3	0.5	0.6	-0.7	0.4
Average weekly spirits intake	0.2	0.3	0.6	0.8	-0.0	0.4
Ever had hysterectomy (womb removed)	0.2	0.2	0.3	-0.4	0.6	0.4
Medication for hormone replacement therapy	0.2	0.2	0.3	-0.0	0.5	0.6
Townsend deprivation index at recruitment	0.2	0.2	0.4	0.5	-0.2	-0.6
Sitting height	0.2	1.4	3.2	0.4	-0.9	-1.8
Number of incorrect matches in round	0.2	0.3	0.7	0.6	-0.8	-0.2
Had menopause	0.2	0.3	0.4	-0.4	0.6	0.6
Neuroticism score	0.2	0.5	0.9	0.1	-0.8	-1.0
Falls in the last year	0.2	0.3	0.7	0.8	-0.3	0.2
Medication: Lansoprazole	0.2	0.2	0.5	0.7	0.1	-0.1
Lung cancer (father)	0.2	0.2	0.3	0.1	-0.5	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.2	0.4	0.4	-0.4	0.6
Qualifications: O levels/GCSEs or equivalent	0.2	0.2	0.4	-0.6	0.6	0.1
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.7	0.4	-0.4	-0.8
Leg fat percentage (right)	0.2	0.9	1.5	1.2	-1.1	-0.2
Worry too long after embarrassment	0.2	0.4	0.5	0.6	-0.5	-0.7
Emphysema/chronic bronchitis	0.2	0.2	0.4	0.6	-0.4	-0.4
Had major operations	0.2	0.2	0.4	0.0	-0.6	-0.5
Age at last live birth	0.2	0.3	0.6	-0.8	0.5	0.0
Illnesses of father: Heart disease	0.2	0.3	0.4	0.6	-0.6	0.5
Ever had bowel cancer screening	0.2	0.2	0.4	0.6	-0.4	-0.1
Friendships satisfaction	0.2	0.3	0.3	0.6	-0.4	-0.6
Mother’s age at death	0.2	0.3	0.6	-0.3	0.4	0.8
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.2	0.5	-0.5	-0.4
Eye problems/disorders: Glaucoma	0.2	0.3	0.6	-0.2	-0.4	-0.8
Leg fat percentage (left)	0.2	0.8	1.2	1.1	-1.0	-0.2
Number of operations (self-reported)	0.2	0.2	0.4	0.5	-0.6	-0.1
Prostate Cancer	0.1	0.1	0.2	0.4	-0.3	-0.1
Neuroticism (2016)	0.1	0.1	0.4	0.6	0.1	0.1
Chronotype (morning person)	0.1	0.3	0.8	0.1	-0.3	-0.9
Hand grip strength (left)	0.1	0.4	1.0	1.0	-0.1	0.3
Sensitivity / hurt feelings	0.1	0.1	0.2	-0.4	-0.1	0.5
Hearing difficulty/problems: Yes	0.1	0.1	0.2	0.3	0.3	0.5
Vitamin and mineral supplements	0.1	0.2	0.3	0.3	-0.4	-0.6
Medication: Metformin	0.1	0.2	0.3	-0.6	-0.2	-0.4
Pack years adult smoking proportion	0.1	0.1	0.3	-0.1	-0.6	0.2
Hand grip strength (right)	0.1	0.2	0.5	0.7	0.3	0.3
Taking other prescription medications	0.1	0.1	0.1	0.1	-0.4	0.4
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.2	0.5	-0.1	0.2
Multivitamins +/- minerals	0.1	0.1	0.1	-0.4	0.3	0.3
Trunk fat mass	0.1	0.2	0.7	-0.1	-0.8	-0.1
Past tobacco smoking	0.1	0.2	0.3	-0.4	0.3	0.6
Alcohol usually taken with meals	0.1	0.2	0.3	0.2	-0.5	-0.5
Heart attack	0.1	0.1	0.2	0.5	0.3	0.2
Illnesses of siblings	0.1	0.1	0.1	-0.4	0.3	-0.3
Alcohol intake versus 10 years previously	0.1	0.2	0.5	0.2	-0.2	-0.7
Number of live births	0.1	0.1	0.1	0.4	-0.3	0.2
Noisy workplace	0.1	0.1	0.1	-0.3	0.1	0.4
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.2	0.4	0.0	-0.6	-0.3
Prospective memory result	0.1	0.2	0.2	0.4	-0.4	-0.4
Length of working week for main job	0.1	0.1	0.1	-0.3	0.3	0.3
Ever highly irritable/argumentative for 2 days	0.1	0.2	0.2	0.5	-0.2	0.5
High blood pressure (siblings)	0.1	0.1	0.3	-0.1	0.0	0.6
Body fat percentage	0.1	0.6	1.5	-0.1	-1.2	-0.4
Medication: Seretide 50 evohaler	0.1	0.1	0.3	0.5	-0.0	-0.1
Leg fat mass (right)	0.1	0.3	0.5	0.7	-0.3	0.6
Suffer from ‘nerves’	0.1	0.1	0.2	-0.4	0.2	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.2	0.3	0.6	-0.4	0.0
Smoking status: Previous	0.1	0.2	0.5	0.3	-0.0	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.3	0.5	-0.3	0.7	0.6
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.2	0.1	-0.2	0.5
Qualifications: nursing, teaching	0.1	0.1	0.2	0.0	0.5	0.4
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.2	0.2	0.0	0.5
Medication: Lisinopril	0.1	0.2	0.4	-0.1	0.2	0.6
Unable to work because of sickness or disability	0.1	0.2	0.4	0.6	-0.3	0.3
Cholesterol lowering medication	0.1	0.2	0.3	0.5	-0.3	-0.5
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.3	0.3	0.5	0.4
Pack years of smoking	0.1	0.2	0.4	-0.0	-0.7	-0.1
Leg fat mass (left)	0.1	0.3	0.5	0.7	-0.2	0.7
Intelligence (Savage-Jansen 2018)	0.0	0.0	0.1	0.1	0.3	0.2
Alzheimer’s Disease (including proxy)	0.0	0.1	0.1	0.4	-0.2	-0.1
Systolic blood pressure, automated reading	0.0	0.1	0.3	0.2	0.1	0.5
Angina	0.0	0.1	0.1	-0.2	0.1	0.3
Average weekly fortified wine intake	0.0	0.0	0.1	0.3	-0.2	-0.1
Waist circumference	0.0	0.1	0.2	0.4	-0.4	0.3
Medication: Simvastatin	0.0	0.0	0.1	0.1	-0.2	0.3
Fluid intelligence score	0.0	0.1	0.2	-0.1	0.4	-0.0
Happiness	0.0	0.0	0.1	0.1	-0.2	0.1
Gout (self-reported)	0.0	0.0	0.0	0.2	0.0	0.1
Medication: Amlodipine	0.0	0.0	0.1	-0.3	-0.1	-0.0
Medication: Allopurinol	0.0	0.1	0.1	0.3	0.2	0.2
Whole body fat mass	0.0	0.2	0.5	-0.1	-0.2	0.7
Comparative height size at age 10	0.0	0.2	0.4	-0.1	-0.6	-0.6
Commuting to job workplace: Car/motor vehicle	0.0	0.0	0.1	0.2	-0.3	0.2
Mouth/teeth dental problems: Mouth ulcers	0.0	0.1	0.1	0.2	0.3	0.2
Osteoporosis (self-reported)	0.0	0.0	0.0	-0.1	-0.1	-0.1
Pain type(s) experienced in last month: Hip pain	0.0	0.0	0.1	0.2	0.3	-0.0
Ever smoked	0.0	0.0	0.0	0.2	-0.2	0.0
Commuting to job workplace: Cycle	0.0	0.1	0.1	0.2	0.1	0.3

Hub : Genes

YY1AP1

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Trait associations