Hub : Genes

YY1AP1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.3530 0.0590 0.0e+00 0.515 0.485 0.515 0.518 0.513 5.5e-73 5.1e-67 7.3e-73 1.4e-73 1.4e-72
2 GTEx Testis 0.5430 0.0980 3.7e-12 0.341 NA 0.343 NA 0.383 7.7e-16 NA 5.8e-16 NA 4.7e-18
3 TCGA Breast Invasive Carcinoma 0.0269 0.0212 4.1e-04 0.008 0.010 0.011 NA 0.010 7.6e-03 2.7e-03 1.6e-03 NA 3.7e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 3.8 6.0 7.6 2.8 -2.2 -2.3
Bipolar Disorder or Schizophrenia 3.5 8.6 10.5 3.2 -2.9 -2.7
Depressed Affect (Nagel 2018) 1.4 2.9 3.5 1.5 -1.7 -1.9
Depression (Nagel 2018) 1.8 2.7 3.9 2.0 -1.7 -1.2
Intelligence (Savage-Jansen 2018) 0.0 0.0 0.1 0.1 0.3 0.2
Neuroticism (Nagel 2018) 0.4 0.9 1.1 0.7 -1.1 -1.0
Schizophrenia (2018) 1.6 3.3 3.8 1.9 -1.9 -1.6
Schizophrenia vs Biploar Disorder 0.2 0.2 0.5 -0.3 0.2 0.7
Worry (Nagel 2018) 0.6 1.2 2.7 -1.7 0.7 0.6
Alzheimer’s Disease (in mother) 0.8 0.9 1.1 0.9 -1.1 -0.9
Alzheimer’s Disease (in father) 0.8 0.8 1.3 -0.7 1.1 0.9
Alzheimer’s Disease (including proxy) 0.0 0.1 0.1 0.4 -0.2 -0.1
Crohns Disease (2017) 12.9 28.3 31.8 5.1 -5.2 -5.6
Irritable Bowel Disease (IBD) 8.7 20.8 22.4 4.7 -4.3 -4.7
Ulcerative Colitis (UC) 2.1 3.9 5.3 2.3 -1.6 -1.9
Major Depression (MDD) 0.3 0.4 1.0 0.4 -0.4 -1.0
Reaction Time 1.3 2.4 3.0 1.5 -1.7 -1.4
Verbal and Numeric Reasoning (VNR) 0.4 1.1 1.5 -0.7 1.2 1.1
Breast Cancer 11.6 27.8 34.8 -4.4 5.9 5.4
Ovarian Cancer 0.4 0.6 0.7 0.9 -0.6 -0.8
Prostate Cancer 0.1 0.1 0.2 0.4 -0.3 -0.1
Age at First Birth 0.6 0.9 2.0 0.9 -1.4 0.0
Bipolar Disorder (2011) 0.3 0.3 0.5 0.6 -0.7 0.0
Body Mass Index (BMI) (2010) 2.0 2.7 5.1 -1.8 2.2 0.0
Coronary Artery Disease (CAD) 0.5 0.6 1.4 -0.5 1.2 0.0
Crohns Disease (2012) 13.4 21.5 22.4 4.5 -4.7 -4.7
Mean Putamen Volume 3.9 4.4 5.7 2.4 -2.2 -1.7
Fasting Glucose 0.6 0.7 0.9 0.9 -0.7 -1.0
HbA1C 0.3 0.3 0.9 0.0 0.0 0.9
HDL Cholesterol 1.1 1.8 2.7 -1.6 1.6 0.0
LDL Cholesterol 0.7 1.1 1.8 1.4 -1.2 0.0
Lupus 0.2 0.3 0.9 0.2 0.2 0.9
Neuroticism (2016) 0.1 0.1 0.4 0.6 0.1 0.1
Primary Biliary Cirrhosis 0.5 0.7 0.8 0.9 -0.8 -0.8
Rheumatoid Arthritis 1.4 1.9 3.1 -1.3 1.8 1.0
Schizophrenia (2014) 3.2 7.0 8.2 2.8 -2.9 -2.2
Triglycerides 0.2 0.4 0.6 0.8 -0.7 0.0
Type 2 Diabetes (T2D) (2012) 0.2 0.2 0.4 0.6 -0.5 0.0
Ulcerative Colitis 0.5 0.8 1.2 1.1 -0.6 -0.9
Blood Eosinophil Count 0.5 3.6 6.8 -2.6 1.4 1.4
Blood Platelet Count 0.2 2.6 3.8 0.7 -1.9 -1.9
Blood Red Count 0.2 1.8 2.0 -1.2 1.3 1.4
Blood White Count 0.3 2.0 3.3 1.0 -1.8 -1.3
Heel T-Score 0.4 3.0 4.0 1.8 -2.0 -1.3
BMI 1.1 6.2 12.0 -1.2 2.2 3.5
Height 0.4 7.4 8.5 2.5 -2.7 -2.9
Waist Hip Ratio (WHR) 1.7 7.7 12.7 0.4 -3.6 -3.2
Systolic Blood Pressure 0.4 1.8 2.6 1.0 -1.6 -1.4
Smoking Status 2.0 4.7 5.1 2.1 -2.3 -2.1
Allergy or Eczema 3.2 8.3 11.4 2.6 -3.4 -2.6
Cardiovascular Disease 1.6 5.2 6.2 2.5 -2.5 -1.8
Hypothyroidism (self reported) 0.4 0.9 1.7 0.0 0.9 1.3
Respiratory disease 2.7 5.9 6.4 2.5 -2.4 -2.4
Type 2 Diabetes (T2D) (2018) 0.5 0.9 2.1 -0.1 -0.7 -1.4
Lung FEV1/FVC ratio 0.2 0.8 1.7 -1.3 -0.4 0.8
Lung FVC 3.3 16.7 24.0 -2.5 4.5 4.9
Neuroticism 0.3 0.7 1.1 -0.0 -0.9 -1.0
Chronotype (morning person) 0.1 0.3 0.8 0.1 -0.3 -0.9
Hair Pigment 0.8 23.5 33.6 4.5 -4.0 -5.8
Tanning 1.6 19.7 28.2 5.3 -4.6 -3.1
Hand grip strength (left) 0.1 0.4 1.0 1.0 -0.1 0.3
Number of treatments/medications taken 0.2 0.3 0.5 0.6 -0.7 0.4
Average weekly spirits intake 0.2 0.3 0.6 0.8 -0.0 0.4
Sensitivity / hurt feelings 0.1 0.1 0.2 -0.4 -0.1 0.5
Frequency of depressed mood in last 2 weeks 2.8 3.9 4.7 2.0 -2.2 -1.8
Hearing difficulty/problems: Yes 0.1 0.1 0.2 0.3 0.3 0.5
Relative age of first facial hair 0.5 1.1 1.5 1.2 -1.1 -0.6
Other serious medical condition/disability diagnosed by doctor 1.0 1.3 1.9 1.2 -1.4 -0.9
Ever used hormone-replacement therapy (HRT) 1.6 2.0 2.6 -1.1 1.6 1.6
Ever had hysterectomy (womb removed) 0.2 0.2 0.3 -0.4 0.6 0.4
Systolic blood pressure, automated reading 0.0 0.1 0.3 0.2 0.1 0.5
Eye problems/disorders: Diabetes related eye disease 0.6 0.6 0.8 -0.9 0.8 0.7
Angina 0.0 0.1 0.1 -0.2 0.1 0.3
Medication for hormone replacement therapy 0.2 0.2 0.3 -0.0 0.5 0.6
Vitamin and mineral supplements 0.1 0.2 0.3 0.3 -0.4 -0.6
Supplements: Zinc 1.7 1.8 2.8 -0.8 1.7 1.5
Medication: Co-codamol 1.0 1.2 2.3 -0.6 0.9 1.5
Medication: Metformin 0.1 0.2 0.3 -0.6 -0.2 -0.4
Diabetes (father) 0.3 0.4 0.6 0.8 -0.5 -0.5
Diabetes (mother) 0.8 1.0 1.9 0.6 -1.4 -0.9
Severe depression (siblings) 2.3 2.5 3.5 1.2 -1.9 -1.6
Pack years adult smoking proportion 0.1 0.1 0.3 -0.1 -0.6 0.2
Impedance of leg (right) 5.7 27.5 42.2 2.8 -5.7 -6.5
Leg fat-free mass (left) 1.4 7.3 12.5 -1.1 2.9 3.5
Trunk fat percentage 0.3 1.3 2.7 -0.3 -1.6 -1.0
Hand grip strength (right) 0.1 0.2 0.5 0.7 0.3 0.3
Townsend deprivation index at recruitment 0.2 0.2 0.4 0.5 -0.2 -0.6
Current tobacco smoking 3.7 6.0 6.9 2.6 -2.6 -2.1
Average weekly fortified wine intake 0.0 0.0 0.1 0.3 -0.2 -0.1
Maternal smoking around birth 1.5 2.2 2.9 1.4 -1.7 -1.3
Fed-up feelings 0.6 1.0 1.7 0.8 -0.9 -1.3
Frequency of unenthusiasm / disinterest in last 2 weeks 1.3 1.8 2.7 1.6 -1.3 -1.0
Relative age voice broke 0.8 1.2 2.3 1.5 -1.0 -0.7
Taking other prescription medications 0.1 0.1 0.1 0.1 -0.4 0.4
Age when periods started (menarche) 0.5 1.2 2.1 1.1 -1.4 -0.6
Bilateral oophorectomy (both ovaries removed) 0.1 0.1 0.2 0.5 -0.1 0.2
Heel bone mineral density (BMD) T-score, automated (left) 0.4 0.9 1.4 1.0 -1.2 -0.6
Tinnitus: Yes, but not now, but have in the past 4.4 4.7 5.5 -2.3 2.2 2.0
Qualifications: CSEs or equivalent 1.8 2.3 3.0 1.7 -1.7 -1.1
Serious illness, injury or assault to yourself 0.4 0.5 1.4 0.0 -1.2 -0.4
High blood pressure 1.0 2.8 4.1 2.0 -1.7 -1.3
Hayfever, allergic rhinitis or eczema 3.9 8.4 10.8 2.5 -3.3 -2.8
Multivitamins +/- minerals 0.1 0.1 0.1 -0.4 0.3 0.3
Stomach or abdominal pain in last month 0.6 0.8 0.9 -0.9 0.8 0.9
Supplements: Glucosamine 0.9 1.2 2.5 -0.4 0.9 1.6
Diverticular disease/diverticulitis (self-reported) 0.4 0.5 0.7 -0.8 0.5 0.7
Medication: Atenolol 0.3 0.4 0.4 0.6 -0.6 -0.6
Medication: Levothyroxine sodium 0.7 1.2 1.8 -0.8 1.1 1.3
Sitting height 0.2 1.4 3.2 0.4 -0.9 -1.8
Chronic bronchitis/emphysema (father) 0.8 0.9 1.5 -0.4 1.2 1.1
High blood pressure (mother) 3.3 4.7 5.1 -2.1 2.1 2.3
Body mass index (BMI) 1.3 5.5 11.3 -0.6 2.2 3.4
Impedance of leg (left) 5.9 28.8 44.6 2.8 -5.8 -6.7
Leg predicted mass (left) 1.5 7.9 13.3 -1.2 3.0 3.6
Trunk fat mass 0.1 0.2 0.7 -0.1 -0.8 -0.1
Waist circumference 0.0 0.1 0.2 0.4 -0.4 0.3
Number of incorrect matches in round 0.2 0.3 0.7 0.6 -0.8 -0.2
Past tobacco smoking 0.1 0.2 0.3 -0.4 0.3 0.6
Alcohol usually taken with meals 0.1 0.2 0.3 0.2 -0.5 -0.5
Nervous feelings 2.4 4.4 5.3 -2.3 2.0 2.0
Frequency of tenseness / restlessness in last 2 weeks 1.0 1.6 2.1 1.4 -1.2 -1.0
Hearing difficulty/problems with background noise 0.4 0.6 1.2 -0.5 0.7 1.1
Hair/balding pattern: Pattern 2 2.7 3.5 5.0 2.2 -1.9 -1.4
Had menopause 0.2 0.3 0.4 -0.4 0.6 0.6
Had other major operations 1.5 1.8 2.8 1.5 -1.7 -0.6
Forced vital capacity (FVC) 0.8 3.1 4.5 -0.7 2.0 2.1
Heel bone mineral density (BMD) T-score, automated (right) 1.0 2.4 3.1 1.4 -1.8 -1.4
Ever unenthusiastic/disinterested for a whole week 0.4 0.5 1.1 0.1 0.6 1.1
Qualifications: None of the above 0.7 1.5 2.7 -0.9 1.0 1.6
Financial difficulties in last 2 years 2.8 3.7 6.4 -1.5 1.6 2.5
Mouth/teeth dental problems 0.4 0.6 1.1 -0.3 1.1 0.7
Heart attack 0.1 0.1 0.2 0.5 0.3 0.2
Allergy 3.7 8.5 10.1 -2.6 2.9 3.2
Pain all over the body in last month 3.5 3.8 4.2 -2.0 1.8 1.9
Diabetes (self-reported) 1.0 1.6 2.6 0.2 -1.5 -1.6
Hayfever/allergic rhinitis (self-reported) 1.5 2.0 2.5 1.2 -1.5 -1.6
Medication: Ramipril 11.0 14.1 15.5 3.9 -3.7 -3.6
Medication: Simvastatin 0.0 0.0 0.1 0.1 -0.2 0.3
Fluid intelligence score 0.0 0.1 0.2 -0.1 0.4 -0.0
Illnesses of siblings 0.1 0.1 0.1 -0.4 0.3 -0.3
Neuroticism score 0.2 0.5 0.9 0.1 -0.8 -1.0
Weight 0.4 1.8 4.1 0.0 1.2 2.0
Impedance of arm (right) 3.3 15.4 26.8 -1.2 -4.2 -5.2
Arm fat percentage (right) 0.4 1.7 2.5 -1.6 0.6 1.5
Trunk fat-free mass 1.5 8.3 14.7 -0.1 3.2 3.8
Hip circumference 0.4 1.9 3.8 0.2 1.4 1.9
Time employed in main current job 3.0 3.5 5.1 -2.3 1.8 1.5
Alcohol intake versus 10 years previously 0.1 0.2 0.5 0.2 -0.2 -0.7
Father’s age at death 0.4 0.5 0.9 -1.0 0.8 -0.1
Worrier / anxious feelings 2.0 3.8 6.5 -2.5 1.7 1.5
Frequency of tiredness / lethargy in last 2 weeks 0.7 1.1 2.6 1.6 -0.9 -0.2
Falls in the last year 0.2 0.3 0.7 0.8 -0.3 0.2
Hair/balding pattern: Pattern 3 1.3 2.0 4.0 -2.0 1.1 0.8
Number of live births 0.1 0.1 0.1 0.4 -0.3 0.2
Forced expiratory volume in 1-second (FEV1) 0.8 2.6 4.7 -0.8 1.6 2.2
Pulse rate 0.3 0.5 0.7 0.8 -0.1 -0.9
Happiness 0.0 0.0 0.1 0.1 -0.2 0.1
Noisy workplace 0.1 0.1 0.1 -0.3 0.1 0.4
Qualifications: A levels/AS levels or equivalent 0.3 0.6 1.0 -1.0 1.0 -0.1
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.2 0.4 0.0 -0.6 -0.3
Mouth/teeth dental problems: Dentures 0.7 1.2 2.1 0.6 -1.5 -1.0
Asthma 3.1 6.1 8.2 2.4 -2.1 -2.9
Medication: Ibuprofen (e.g. Nurofen) 7.1 9.0 10.7 -2.5 3.1 3.3
Medication: Cholesterol lowering 0.3 0.4 0.7 0.7 -0.8 -0.2
Depression (self-reported) 0.7 0.9 1.4 0.6 -1.2 -0.9
Medication: Lansoprazole 0.2 0.2 0.5 0.7 0.1 -0.1
Prospective memory result 0.1 0.2 0.2 0.4 -0.4 -0.4
Lung cancer (father) 0.2 0.2 0.3 0.1 -0.5 -0.6
Illnesses of mother 0.3 0.3 0.7 0.8 -0.2 -0.4
Forced expiratory volume in 1-second (FEV1), Best measure 1.0 3.3 4.9 -1.2 1.9 2.2
Pulse wave Arterial Stiffness index 3.5 4.1 5.9 1.7 -1.8 -2.4
Impedance of arm (left) 3.7 17.3 31.1 -0.9 -4.5 -5.6
Arm fat mass (right) 0.7 2.9 5.7 -1.1 1.3 2.4
Trunk predicted mass 1.5 8.3 14.7 -0.0 3.2 3.8
Standing height 0.3 3.4 5.5 1.1 -1.9 -2.3
Length of working week for main job 0.1 0.1 0.1 -0.3 0.3 0.3
Exposure to tobacco smoke at home 1.6 1.7 2.6 -1.1 1.2 1.6
Breastfed as a baby 1.8 2.3 3.1 1.8 -1.4 -1.4
Tense / ‘highly strung’ 1.6 2.7 3.4 1.5 -1.5 -1.9
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.2 0.4 0.4 -0.4 0.6
Hair/balding pattern: Pattern 4 0.5 1.2 1.4 -1.0 1.2 1.1
Birth weight of first child 0.3 0.5 0.8 -0.8 -0.2 -0.9
Peak expiratory flow (PEF) 0.4 0.9 2.1 -0.5 0.5 1.4
Pulse wave reflection index 2.1 2.6 2.8 1.6 -1.7 -1.6
Ever highly irritable/argumentative for 2 days 0.1 0.2 0.2 0.5 -0.2 0.5
Loud music exposure frequency 2.4 2.6 3.8 -1.6 1.1 1.9
Qualifications: O levels/GCSEs or equivalent 0.2 0.2 0.4 -0.6 0.6 0.1
Mouth/teeth dental problems: Bleeding gums 0.3 0.4 1.1 0.1 -0.4 -1.1
Blood clot in the leg (DVT) 0.7 0.9 1.2 1.0 -0.6 -1.1
Medication: Paracetamol 2.3 3.8 3.8 -2.0 1.9 1.9
Headache pain in last month 0.3 0.6 1.5 -0.2 0.5 1.2
Medication for cholesterol, blood pressure or diabetes 3.5 5.8 6.8 -2.5 2.6 2.1
Glaucoma (self-reported) 0.3 0.3 0.5 0.1 -0.6 -0.7
Gout (self-reported) 0.0 0.0 0.0 0.2 0.0 0.1
Hypothyroidism/myxoedema (self-reported) 1.8 3.5 5.2 -1.2 1.9 2.3
Medication: Amlodipine 0.0 0.0 0.1 -0.3 -0.1 -0.0
Medication: Ventolin 100micrograms inhaler 0.2 0.3 0.7 0.4 -0.4 -0.8
Birth weight 2.2 4.8 7.2 -2.7 2.2 1.6
Chronic bronchitis/emphysema (mother) 0.4 0.5 1.1 1.0 -0.5 -0.3
High blood pressure (siblings) 0.1 0.1 0.3 -0.1 0.0 0.6
Forced vital capacity (FVC), Best measure 0.8 3.0 4.5 -0.8 2.0 2.1
Body fat percentage 0.1 0.6 1.5 -0.1 -1.2 -0.4
Leg fat percentage (right) 0.2 0.9 1.5 1.2 -1.1 -0.2
Arm fat-free mass (right) 0.9 4.5 8.1 0.8 2.2 2.9
Exposure to tobacco smoke outside home 0.6 0.7 1.0 0.9 -1.0 -0.6
Comparative body size at age 10 3.3 9.2 11.5 -2.6 3.0 3.4
Number of full brothers 4.1 5.1 6.2 2.5 -2.5 -1.8
Worry too long after embarrassment 0.2 0.4 0.5 0.6 -0.5 -0.7
Seen a psychiatrist for nerves, anxiety, tension or depression 2.3 2.9 3.7 1.6 -1.9 -1.6
Wheeze or whistling in the chest in last year 0.9 1.7 3.0 1.7 -1.2 -0.8
Number of children fathered 0.5 0.6 1.2 1.1 -0.7 -0.3
Reason for reducing amount of alcohol drunk: Health precaution 1.7 2.0 2.9 1.0 -1.5 -1.7
Age at first live birth 1.0 1.8 2.2 -1.5 1.4 1.1
Pulse wave peak to peak time 3.1 3.7 5.1 -1.8 1.7 2.2
Health satisfaction 2.2 2.8 3.7 -1.4 1.7 1.9
Shortness of breath walking on level ground 3.0 3.6 4.6 -1.8 1.7 2.1
Qualifications: College or University degree 1.3 4.0 5.2 -2.1 2.3 1.6
Eye problems/disorders: None of the above 1.1 1.3 2.6 -0.8 0.8 1.6
Mouth/teeth dental problems: Loose teeth 0.5 0.6 0.8 0.7 -0.9 -0.6
Emphysema/chronic bronchitis 0.2 0.2 0.4 0.6 -0.4 -0.4
Medication for pain relief, constipation, heartburn 2.1 3.6 6.6 1.5 -1.5 -2.6
Neck or shoulder pain in last month 2.5 3.5 5.7 -0.6 2.1 2.4
Medication: Blood pressure 3.3 5.8 6.9 2.5 -2.6 -2.1
Angina (self-reported) 0.3 0.4 0.7 -0.5 0.5 0.9
Migraine (self-reported) 2.3 2.8 3.5 -1.9 1.4 1.7
Medication: Ibuprofen 6.2 7.4 8.8 -2.5 2.7 3.0
Medication: Allopurinol 0.0 0.1 0.1 0.3 0.2 0.2
Medication: Omeprazole 0.3 0.4 1.0 -0.3 0.1 1.0
Medication: Seretide 50 evohaler 0.1 0.1 0.3 0.5 -0.0 -0.1
Mean time to correctly identify matches 0.9 1.8 2.6 1.4 -1.6 -0.8
Heart disease (mother) 3.5 4.2 5.3 -2.3 1.7 2.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 5.8 6.9 7.7 2.8 -2.8 -2.4
Whole body fat mass 0.0 0.2 0.5 -0.1 -0.2 0.7
Leg fat mass (right) 0.1 0.3 0.5 0.7 -0.3 0.6
Arm predicted mass (right) 0.9 4.4 7.7 0.9 2.2 2.8
Pulse rate, automated reading 0.3 0.9 1.3 -1.1 1.0 0.6
Alcohol intake frequency. 0.9 2.0 3.8 -1.1 1.1 1.9
Comparative height size at age 10 0.0 0.2 0.4 -0.1 -0.6 -0.6
Number of full sisters 1.1 1.3 2.8 1.7 -1.0 0.4
Suffer from ‘nerves’ 0.1 0.1 0.2 -0.4 0.2 0.2
Overall health rating 0.7 1.6 2.9 -1.0 0.9 1.7
Chest pain or discomfort 1.7 2.5 3.0 1.7 -1.6 -1.3
Had major operations 0.2 0.2 0.4 0.0 -0.6 -0.5
Age at last live birth 0.2 0.3 0.6 -0.8 0.5 0.0
Family relationship satisfaction 2.0 2.5 3.1 1.4 -1.8 -1.6
Leg pain on walking 3.1 3.9 7.1 -1.1 1.9 2.7
Qualifications: NVQ or HND or HNC or equivalent 0.8 0.9 1.2 1.1 -1.1 -0.7
Commuting to job workplace: Car/motor vehicle 0.0 0.0 0.1 0.2 -0.3 0.2
Illness, injury, bereavement, stress in last 2 years 0.3 0.3 0.8 0.5 -0.1 -0.9
Medication: Aspirin 0.6 0.8 1.6 0.8 -1.3 -0.5
Supplements: Vitamin C 0.7 0.9 1.1 -0.8 1.0 1.0
Knee pain experienced in last month 1.1 1.7 3.0 -0.5 1.4 1.7
Hypertension (Self-reported) 1.8 5.1 6.2 2.5 -2.4 -1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.2 0.3 0.6 -0.4 0.0
Illnesses of father: Heart disease 0.2 0.3 0.4 0.6 -0.6 0.5
Illnesses of siblings: Diabetes 0.5 0.6 0.8 -0.6 0.8 0.9
Smoking status: Previous 0.1 0.2 0.5 0.3 -0.0 -0.7
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.3 0.5 -0.3 0.7 0.6
Whole body fat-free mass 1.4 8.2 14.6 -0.4 3.1 3.8
Leg fat-free mass (right) 1.6 8.6 14.3 -1.3 3.1 3.8
Arm fat percentage (left) 0.3 1.0 1.7 -1.3 0.3 1.2
Average weekly red wine intake 0.6 0.8 1.4 0.4 -1.0 -1.2
Handedness (chirality/laterality): Left-handed 0.1 0.1 0.2 0.1 -0.2 0.5
Mood swings 0.3 0.5 0.8 0.3 -0.9 -0.9
Loneliness, isolation 1.1 1.5 1.9 1.2 -1.1 -1.4
Long-standing illness, disability or infirmity 0.8 1.2 2.4 1.1 -1.5 -0.5
Ever had bowel cancer screening 0.2 0.2 0.4 0.6 -0.4 -0.1
Diabetes diagnosed by doctor 0.8 1.3 2.5 0.2 -1.2 -1.6
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.8 1.1 0.8 -0.9 -1.0
Friendships satisfaction 0.2 0.3 0.3 0.6 -0.4 -0.6
Qualifications: nursing, teaching 0.1 0.1 0.2 0.0 0.5 0.4
Commuting to job workplace: Walk 0.4 0.4 0.9 -1.0 0.6 0.1
Eye problems/disorders: Cataract 0.6 0.7 0.9 0.9 -0.7 -0.8
Mouth/teeth dental problems: Mouth ulcers 0.0 0.1 0.1 0.2 0.3 0.2
Medication for cholesterol 0.4 0.5 0.7 -0.9 0.8 0.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.0 2.4 3.3 -1.8 1.4 1.3
Back pain experienced in last month 0.8 1.2 2.7 -0.2 0.9 1.6
Mineral and other dietary supplements 0.3 0.3 0.8 -0.4 -0.3 -0.9
Breast cancer (self-reported) 3.6 4.3 6.5 2.5 -2.0 -1.5
Asthma (self-reported) 3.6 7.2 8.8 2.7 -2.4 -3.0
Osteoporosis (self-reported) 0.0 0.0 0.0 -0.1 -0.1 -0.1
Osteoarthritis (self-reported) 2.2 2.8 4.6 -1.3 1.5 2.1
Medication: Aspirin 0.6 0.8 1.6 0.9 -1.2 -0.3
Medication: Gliclazide 1.2 1.4 2.6 0.4 -1.1 -1.6
Illnesses of father: None of the above (group 1) 1.2 1.5 1.7 1.1 -1.3 -1.3
Smoking status: Current 2.4 3.7 4.7 1.9 -2.2 -1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.1 2.4 -0.2 0.8 1.5
Whole body water mass 1.5 8.3 14.8 -0.4 3.2 3.9
Leg predicted mass (right) 1.6 8.8 14.4 -1.4 3.1 3.8
Arm fat mass (left) 0.5 2.1 4.5 -0.9 1.0 2.1
Number of self-reported non-cancer illnesses 1.1 2.0 2.7 1.3 -1.6 -1.2
Average weekly champagne plus white wine intake 0.3 0.4 0.9 -0.9 0.5 0.3
Miserableness 1.9 3.3 3.6 1.8 -1.8 -1.9
Guilty feelings 2.8 4.2 7.1 2.7 -1.9 -1.4
Wears glasses or contact lenses 0.7 0.8 1.2 -0.0 -1.1 -1.1
Ever taken oral contraceptive pill 0.3 0.4 0.5 0.4 -0.7 -0.7
Hearing aid user 0.8 0.9 1.5 -0.4 0.9 1.2
Mother’s age at death 0.2 0.3 0.6 -0.3 0.4 0.8
Financial situation satisfaction 1.3 1.6 2.1 1.4 -1.3 -1.0
Tinnitus: Yes, now most or all of the time 0.2 0.2 0.2 0.5 -0.5 -0.4
Commuting to job workplace: Public transport 1.1 1.4 1.5 -1.2 1.2 1.1
Eye problems/disorders: Glaucoma 0.2 0.3 0.6 -0.2 -0.4 -0.8
Medication: Blood pressure 0.7 1.2 1.9 1.4 -1.0 -0.9
Pain type(s) experienced in last month: Hip pain 0.0 0.0 0.1 0.2 0.3 -0.0
Supplements: Fish oil (including cod liver oil) 0.1 0.1 0.2 0.2 0.0 0.5
High cholesterol (Self-reported) 0.5 0.9 1.9 1.4 -0.8 -0.3
Medication: Bendroflumethiazide 0.4 0.6 1.0 1.0 -0.5 -0.7
Medication: Paracetamol 2.0 3.1 4.1 -2.0 1.7 1.6
Medication: Lisinopril 0.1 0.2 0.4 -0.1 0.2 0.6
Medication: Atorvastatin 2.0 2.5 3.6 1.9 -1.5 -1.3
Illnesses of father: High blood pressure 0.8 1.1 1.9 -0.1 1.4 1.1
Alcohol drinker status: Never 0.3 0.4 0.6 -0.6 0.7 0.5
Ever smoked 0.0 0.0 0.0 0.2 -0.2 0.0
Basal metabolic rate 1.2 6.9 12.6 -0.4 2.8 3.5
Leg fat percentage (left) 0.2 0.8 1.2 1.1 -1.0 -0.2
Arm fat-free mass (left) 1.4 7.0 12.8 0.2 2.8 3.6
Number of operations (self-reported) 0.2 0.2 0.4 0.5 -0.6 -0.1
Average weekly beer plus cider intake 1.7 2.4 2.9 -1.6 1.7 1.3
Irritability 1.1 1.8 3.6 0.6 -1.2 -1.9
Risk taking 2.0 2.9 3.4 1.6 -1.7 -1.8
Ever had prostate specific antigen (PSA) test 0.7 0.9 1.0 -0.9 0.8 1.0
Fractured/broken bones in last 5 years 0.9 1.2 1.6 1.3 -0.7 -1.2
Age started oral contraceptive pill 0.5 0.6 1.4 -1.2 0.7 0.1
Diastolic blood pressure, automated reading 0.8 2.4 2.6 -1.6 1.6 1.4
Ever depressed for a whole week 0.6 0.7 1.1 0.9 -1.1 -0.5
Unable to work because of sickness or disability 0.1 0.2 0.4 0.6 -0.3 0.3
Commuting to job workplace: Cycle 0.0 0.1 0.1 0.2 0.1 0.3
Myopia 2.6 3.8 5.3 1.8 -1.7 -2.3
Vascular/heart problems diagnosed by doctor 1.2 3.4 4.7 -2.2 1.8 1.4
Cholesterol lowering medication 0.1 0.2 0.3 0.5 -0.3 -0.5
Medication: Omeprazole (e.g. Zanprol) 0.3 0.4 0.8 -0.5 0.0 0.9
Pain experienced in last month 8.4 14.1 18.5 2.9 -3.9 -4.3
Supplements: Calcium 0.3 0.3 0.4 0.3 -0.6 -0.7
Basal cell carcinoma (self-reported) 0.7 0.8 1.0 -1.0 0.9 0.7
Heart attack/myocardial infarction (self-reported) 0.1 0.2 0.3 0.3 0.5 0.4
Deep venous thrombosis (DVT) (self-reported) 0.8 1.0 1.3 1.1 -0.7 -1.1
Heart disease (siblings) 0.8 1.0 1.8 -0.5 0.9 1.3
Alcohol drinker status: Previous 2.2 2.5 3.6 1.9 -1.5 -1.3
Pack years of smoking 0.1 0.2 0.4 -0.0 -0.7 -0.1
Impedance of whole body 5.0 25.5 44.8 0.8 -5.6 -6.7
Leg fat mass (left) 0.1 0.3 0.5 0.7 -0.2 0.7
Arm predicted mass (left) 1.3 6.6 12.2 0.3 2.7 3.5