Hub : Genes

FDPS

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.036	0.0180	1.1e-03	0.039	0.033	0.026	0.034	0.035	1.3e-05	6.2e-05	3.5e-04	4.2e-05	3.3e-05
2	GTEx	Spleen	0.137	0.0700	5.5e-03	-0.006	NA	0.003	NA	-0.008	4.8e-01	NA	2.6e-01	NA	5.7e-01
3	TCGA	Prostate Adenocarcinoma	0.024	0.0211	8.0e-03	0.020	0.008	0.003	NA	0.012	3.1e-03	4.7e-02	1.5e-01	NA	1.6e-02
4	TCGA	Thyroid Carcinoma	0.160	0.0740	2.2e-16	0.173	0.174	0.184	NA	0.174	1.3e-16	1.2e-16	1.2e-17	NA	1.1e-16

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	4.4	6.9	8.9	-3.0	2.4	-2.7	2.4
Bipolar Disorder or Schizophrenia	3.9	9.6	11.9	-3.3	3.5	-2.9	2.6
Depressed Affect (Nagel 2018)	1.7	3.7	4.2	-2.0	2.0	-1.8	1.8
Depression (Nagel 2018)	2.6	3.8	4.7	-2.2	2.0	-1.7	2.0
Intelligence (Savage-Jansen 2018)	0.3	1.1	1.9	0.9	-1.4	0.9	-0.9
Neuroticism (Nagel 2018)	0.1	0.2	0.3	-0.5	-0.1	0.5	0.5
Schizophrenia (2018)	1.9	3.9	6.3	-1.9	2.5	-1.5	1.9
Schizophrenia vs Biploar Disorder	0.0	0.1	0.1	0.4	0.0	0.3	-0.1
Worry (Nagel 2018)	3.2	6.8	9.9	2.1	-2.8	3.1	-2.2
Alzheimer’s Disease (in mother)	0.3	0.4	0.9	-0.6	0.1	-0.6	0.9
Alzheimer’s Disease (in father)	1.3	1.4	2.0	1.1	-1.3	1.4	-0.9
Alzheimer’s Disease (including proxy)	0.1	0.1	0.2	0.0	-0.5	0.3	0.3
Crohns Disease (2017)	12.1	26.5	29.5	-5.4	5.0	-5.3	4.8
Irritable Bowel Disease (IBD)	10.9	25.9	28.8	-5.2	5.0	-5.4	4.7
Ulcerative Colitis (UC)	4.6	8.6	10.2	-2.9	3.1	-3.2	2.5
Major Depression (MDD)	0.3	0.3	0.6	-0.6	0.7	-0.5	0.4
Reaction Time	1.5	2.9	4.6	-1.7	2.1	-1.3	1.4
Verbal and Numeric Reasoning (VNR)	0.6	1.4	2.0	1.4	-1.2	0.9	-1.3
Breast Cancer	12.0	28.8	32.8	5.5	-5.6	5.7	-4.7
Ovarian Cancer	0.2	0.2	0.3	-0.6	-0.5	0.4	0.5
Prostate Cancer	0.1	0.2	0.3	-0.5	0.4	-0.3	0.4
Age at First Birth	0.1	0.1	0.2	0.1	-0.5	0.4	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	1.9	2.6	4.4	1.5	-2.1	1.2	-1.6
Coronary Artery Disease (CAD)	0.2	0.3	0.8	0.9	-0.4	0.5	0.0
Crohns Disease (2012)	15.9	25.7	30.1	-5.3	4.7	-5.5	4.8
Mean Putamen Volume	4.1	4.6	5.4	-2.3	2.0	-2.0	2.3
Fasting Glucose	1.0	1.2	1.8	-1.1	0.9	-1.3	1.1
HbA1C	1.0	1.1	1.5	-0.9	1.1	-1.2	0.8
HDL Cholesterol	1.9	3.1	4.0	1.7	-1.5	1.8	-2.0
LDL Cholesterol	1.1	1.7	2.7	-1.6	0.6	-1.1	1.6
Lupus	0.6	0.9	2.6	0.2	-1.6	0.9	0.3
Neuroticism (2016)	0.1	0.1	0.3	0.0	0.3	0.5	0.0
Primary Biliary Cirrhosis	0.8	1.2	1.6	-1.1	0.8	-1.3	1.1
Rheumatoid Arthritis	0.5	0.8	1.4	0.9	-0.5	0.8	-1.2
Schizophrenia (2014)	3.7	8.3	10.8	-2.9	3.3	-2.8	2.5
Triglycerides	0.5	0.8	1.9	-0.5	1.4	-0.8	0.8
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.4	-1.0	1.2	0.0	0.0
Ulcerative Colitis	1.6	2.3	2.7	-1.6	1.5	-1.6	1.2
Blood Eosinophil Count	0.4	2.7	4.5	2.1	-0.7	1.5	-1.9
Blood Platelet Count	0.5	5.5	11.2	-2.1	3.4	-1.8	1.7
Blood Red Count	0.3	2.6	7.7	-0.5	2.8	-1.5	0.2
Blood White Count	0.9	6.6	9.2	-2.5	3.0	-2.2	2.5
Heel T-Score	0.1	1.0	1.7	-1.1	-1.1	0.1	1.3
BMI	0.1	0.3	0.7	0.8	-0.6	0.5	0.1
Height	0.0	0.1	0.2	-0.5	0.2	0.3	0.1
Waist Hip Ratio (WHR)	0.5	2.5	6.9	-1.1	2.6	-1.1	0.8
Systolic Blood Pressure	0.2	0.8	1.1	-1.1	-1.0	-0.5	0.8
Smoking Status	2.6	6.3	7.9	-2.4	2.8	-2.1	2.7
Allergy or Eczema	1.7	4.4	7.8	-2.8	1.0	-1.5	2.5
Cardiovascular Disease	2.4	7.9	9.8	-2.8	2.2	-3.0	3.1
Hypothyroidism (self reported)	0.0	0.1	0.2	0.2	-0.3	0.5	-0.1
Respiratory disease	1.8	4.0	5.9	-2.4	1.7	-1.3	2.4
Type 2 Diabetes (T2D) (2018)	0.9	1.7	3.1	-0.9	1.6	-1.8	0.6
Lung FEV1/FVC ratio	0.1	0.3	0.7	0.8	0.4	0.4	-0.6
Lung FVC	1.9	9.7	17.5	2.9	-4.2	2.8	-2.3
Neuroticism	0.1	0.1	0.4	0.1	-0.0	0.6	-0.3
Chronotype (morning person)	0.1	0.2	0.7	-0.3	0.8	-0.2	-0.2
Hair Pigment	0.8	23.5	29.5	-5.4	4.7	-5.4	3.7
Tanning	2.4	29.0	32.6	-5.7	4.6	-5.5	5.6
Hand grip strength (left)	0.3	0.8	1.3	-0.9	0.2	-1.1	1.1
Number of treatments/medications taken	0.4	0.8	1.6	-1.0	0.5	-0.5	1.3
Average weekly spirits intake	0.4	0.4	0.8	-0.7	0.2	-0.9	0.7
Sensitivity / hurt feelings	0.3	0.6	1.9	0.6	-0.1	1.4	-0.2
Frequency of depressed mood in last 2 weeks	4.6	6.4	9.5	-2.3	3.1	-2.5	2.1
Hearing difficulty/problems: Yes	0.0	0.1	0.2	-0.0	-0.2	0.4	-0.1
Relative age of first facial hair	0.6	1.2	2.2	-1.4	0.8	-0.4	1.5
Other serious medical condition/disability diagnosed by doctor	1.1	1.4	2.4	-1.1	1.5	-0.9	1.1
Ever used hormone-replacement therapy (HRT)	0.9	1.2	1.9	0.7	-1.2	1.4	-0.9
Ever had hysterectomy (womb removed)	0.5	0.6	0.9	0.6	-0.8	0.9	-0.7
Systolic blood pressure, automated reading	0.2	0.6	2.4	-0.1	-1.6	0.2	0.2
Eye problems/disorders: Diabetes related eye disease	0.7	0.7	1.1	0.9	-1.1	0.6	-0.8
Angina	0.0	0.0	0.1	-0.0	0.1	-0.3	0.2
Medication for hormone replacement therapy	0.2	0.2	0.4	0.0	-0.7	0.6	-0.3
Vitamin and mineral supplements	0.7	0.9	2.0	-0.3	1.4	-1.3	0.3
Supplements: Zinc	1.0	1.1	1.7	0.7	-1.3	1.2	-0.8
Medication: Co-codamol	0.0	0.1	0.1	0.3	-0.2	0.1	-0.3
Medication: Metformin	0.3	0.4	0.9	0.0	0.9	-0.9	-0.1
Diabetes (father)	0.5	0.6	1.1	-0.7	0.4	-0.7	1.0
Diabetes (mother)	1.2	1.5	3.4	-0.8	1.8	-1.1	0.9
Severe depression (siblings)	3.1	3.4	5.4	-1.4	2.3	-1.9	1.7
Pack years adult smoking proportion	0.1	0.1	0.2	0.4	0.4	0.4	-0.0
Impedance of leg (right)	1.4	6.6	13.2	-2.5	3.6	-2.2	1.4
Leg fat-free mass (left)	0.6	3.4	5.4	1.9	-2.3	1.8	-1.1
Trunk fat percentage	0.4	1.5	3.5	1.0	-0.8	1.9	-0.9
Hand grip strength (right)	0.1	0.4	1.2	-0.3	-1.1	-0.0	0.6
Townsend deprivation index at recruitment	1.3	1.8	3.0	-0.8	1.6	-1.7	1.0
Current tobacco smoking	4.5	7.3	9.2	-2.7	2.8	-2.3	3.0
Average weekly fortified wine intake	0.2	0.2	0.7	-0.3	0.3	-0.9	0.0
Maternal smoking around birth	2.3	3.4	4.9	-2.0	1.3	-1.7	2.2
Fed-up feelings	1.2	2.1	3.4	-1.3	1.9	-1.3	1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	2.3	3.1	3.8	-1.7	1.9	-1.6	1.9
Relative age voice broke	1.5	2.3	2.9	-1.7	1.2	-1.3	1.7
Taking other prescription medications	0.1	0.1	0.2	-0.3	0.2	0.1	0.4
Age when periods started (menarche)	0.9	2.1	4.0	-1.0	2.0	-1.3	1.3
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.3	-0.2	0.0	-0.2	0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.1	0.1	-0.2	-0.4	0.0	0.3
Tinnitus: Yes, but not now, but have in the past	4.6	4.9	5.8	2.4	-2.3	2.0	-2.2
Qualifications: CSEs or equivalent	4.4	5.8	8.2	-2.1	2.9	-2.1	2.5
Serious illness, injury or assault to yourself	0.5	0.6	0.9	-0.6	0.7	-1.0	0.8
High blood pressure	0.9	2.5	4.0	-1.8	1.0	-1.4	2.0
Hayfever, allergic rhinitis or eczema	1.9	4.1	7.1	-2.7	1.0	-1.5	2.5
Multivitamins +/- minerals	0.4	0.5	1.3	0.2	-1.2	0.8	-0.2
Stomach or abdominal pain in last month	0.6	0.7	1.6	0.8	0.3	1.3	-0.8
Supplements: Glucosamine	0.8	1.0	2.9	0.3	-1.7	1.0	-0.3
Diverticular disease/diverticulitis (self-reported)	0.7	0.9	1.4	0.6	-1.2	1.2	-0.5
Medication: Atenolol	0.1	0.1	0.2	-0.5	-0.1	-0.5	0.3
Medication: Levothyroxine sodium	0.1	0.2	0.4	0.4	-0.6	0.6	-0.3
Sitting height	0.1	0.5	1.2	0.2	0.9	-0.0	-1.1
Chronic bronchitis/emphysema (father)	0.2	0.3	0.6	0.6	-0.2	0.8	-0.3
High blood pressure (mother)	3.3	4.6	5.6	2.2	-2.2	2.4	-1.7
Body mass index (BMI)	0.2	0.8	1.5	0.9	-1.2	1.0	0.0
Impedance of leg (left)	1.6	7.8	14.9	-2.8	3.9	-2.4	1.6
Leg predicted mass (left)	0.7	3.7	5.6	2.0	-2.4	1.9	-1.2
Trunk fat mass	0.3	1.2	2.8	0.9	-1.0	1.7	-0.6
Waist circumference	0.0	0.2	0.4	-0.4	0.4	-0.0	0.6
Number of incorrect matches in round	0.2	0.4	0.8	-0.6	0.9	-0.2	0.7
Past tobacco smoking	0.7	1.3	1.8	1.3	-1.3	0.9	-1.0
Alcohol usually taken with meals	0.1	0.1	0.2	0.3	-0.3	0.5	-0.4
Nervous feelings	5.1	9.6	12.4	2.7	-3.5	3.5	-2.6
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	1.5	-0.9	1.2	-0.7	1.0
Hearing difficulty/problems with background noise	0.1	0.1	0.3	0.4	-0.2	0.5	-0.1
Hair/balding pattern: Pattern 2	4.6	5.8	8.3	-2.4	1.7	-2.5	2.9
Had menopause	0.4	0.5	0.9	0.5	-0.7	1.0	-0.6
Had other major operations	1.7	2.1	2.4	-1.5	1.3	-1.5	1.5
Forced vital capacity (FVC)	0.8	3.2	5.8	1.6	-2.4	1.6	-1.4
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	1.0	-0.7	0.4	-0.4	1.0
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.3	-0.0	0.5	0.2	0.5
Qualifications: None of the above	0.0	0.1	0.1	0.4	0.3	0.0	-0.0
Financial difficulties in last 2 years	0.1	0.1	0.3	0.6	-0.0	0.1	0.2
Mouth/teeth dental problems	2.4	3.7	7.4	1.2	-2.7	2.0	-1.3
Heart attack	0.9	1.1	2.4	-0.7	1.0	-1.6	0.8
Allergy	1.7	3.9	7.1	2.7	-1.5	1.4	-2.1
Pain all over the body in last month	2.3	2.4	4.0	1.8	-0.9	1.3	-2.0
Diabetes (self-reported)	1.5	2.4	4.3	-0.9	2.1	-2.0	0.6
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	1.4	-1.2	-0.0	-1.0	0.6
Medication: Ramipril	9.9	12.7	13.8	-3.6	3.5	-3.4	3.7
Medication: Simvastatin	0.2	0.3	0.6	-0.5	0.2	-0.8	0.6
Fluid intelligence score	0.1	0.2	0.4	0.4	-0.4	-0.2	-0.6
Illnesses of siblings	0.5	0.7	1.1	0.9	-0.4	0.9	-1.0
Neuroticism score	0.1	0.1	0.4	-0.0	0.4	0.6	-0.0
Weight	0.1	0.7	1.4	0.7	-1.2	1.0	-0.1
Impedance of arm (right)	1.0	4.8	8.2	2.0	-0.5	2.6	-2.9
Arm fat percentage (right)	1.0	4.0	6.4	2.1	-1.8	2.5	-1.5
Trunk fat-free mass	0.1	0.4	1.4	0.4	-1.2	0.3	0.2
Hip circumference	0.1	0.4	1.0	0.3	-1.0	0.6	0.1
Time employed in main current job	2.1	2.4	3.1	1.6	-1.1	1.6	-1.8
Alcohol intake versus 10 years previously	0.1	0.2	0.4	-0.4	0.3	-0.7	0.2
Father’s age at death	0.9	1.2	1.9	1.0	-0.6	1.3	-1.4
Worrier / anxious feelings	3.5	6.6	9.4	2.5	-2.0	3.1	-2.6
Frequency of tiredness / lethargy in last 2 weeks	1.7	2.7	3.5	-1.5	1.9	-1.4	1.7
Falls in the last year	0.4	0.5	1.3	-0.8	0.4	-0.3	1.1
Hair/balding pattern: Pattern 3	1.7	2.5	4.7	1.7	-0.9	1.3	-2.2
Number of live births	0.6	0.8	1.0	-0.6	1.0	-1.0	0.9
Forced expiratory volume in 1-second (FEV1)	0.8	2.8	5.2	1.6	-2.3	1.4	-1.2
Pulse rate	0.1	0.1	0.2	-0.4	-0.1	0.4	-0.1
Happiness	0.1	0.1	0.3	-0.1	0.5	-0.1	0.2
Noisy workplace	0.2	0.2	0.3	-0.6	0.6	-0.4	0.3
Qualifications: A levels/AS levels or equivalent	1.3	3.0	4.7	1.6	-1.7	1.4	-2.2
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	1.6	-0.7	1.3	-1.0	0.7
Mouth/teeth dental problems: Dentures	3.8	6.5	10.6	-2.1	3.3	-2.6	2.0
Asthma	2.5	4.9	6.8	-2.4	2.6	-2.0	1.8
Medication: Ibuprofen (e.g. Nurofen)	3.0	3.8	5.8	2.4	-1.2	2.1	-1.9
Medication: Cholesterol lowering	1.7	2.7	3.3	-1.5	1.8	-1.6	1.6
Depression (self-reported)	0.3	0.3	0.7	-0.7	-0.0	-0.4	0.8
Medication: Lansoprazole	0.3	0.3	0.7	-0.6	-0.8	-0.1	0.4
Prospective memory result	0.3	0.3	0.8	0.1	-0.7	0.9	0.2
Lung cancer (father)	0.3	0.3	0.4	-0.7	0.6	-0.6	0.4
Illnesses of mother	0.9	1.2	2.5	-0.9	1.0	-1.6	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	1.1	3.5	6.1	1.8	-2.5	1.7	-1.4
Pulse wave Arterial Stiffness index	1.0	1.2	2.6	-1.6	0.9	-0.9	0.8
Impedance of arm (left)	0.9	4.3	7.7	1.7	-0.4	2.6	-2.8
Arm fat mass (right)	0.5	2.2	3.6	1.6	-1.5	1.9	-0.8
Trunk predicted mass	0.1	0.4	1.4	0.4	-1.2	0.2	0.2
Standing height	0.0	0.1	0.3	-0.0	-0.1	0.3	-0.5
Length of working week for main job	0.2	0.2	0.5	0.1	0.7	-0.5	-0.0
Exposure to tobacco smoke at home	0.6	0.7	1.6	1.2	-0.8	0.4	-0.7
Breastfed as a baby	2.7	3.3	5.1	-2.1	1.1	-2.3	1.6
Tense / ‘highly strung’	0.2	0.4	0.7	-0.8	0.6	-0.4	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	1.3	-0.6	-0.1	-0.1	1.1
Hair/balding pattern: Pattern 4	1.0	2.5	2.8	1.5	-1.7	1.6	-1.5
Birth weight of first child	0.8	1.5	2.1	1.1	-1.0	1.4	-1.3
Peak expiratory flow (PEF)	0.5	1.1	1.9	1.1	-1.4	1.1	-0.4
Pulse wave reflection index	1.6	1.9	2.3	-1.5	1.3	-1.5	1.2
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.0	-0.6	1.0	0.0	1.0
Loud music exposure frequency	1.3	1.4	2.0	1.2	-0.9	1.4	-1.1
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	1.6	1.0	-0.6	0.7	-1.3
Mouth/teeth dental problems: Bleeding gums	1.2	1.6	3.3	-0.6	1.8	-1.6	0.2
Blood clot in the leg (DVT)	1.8	2.4	3.2	-1.6	1.7	-1.8	1.0
Medication: Paracetamol	0.7	1.2	2.1	1.4	-0.7	0.9	-1.2
Headache pain in last month	0.1	0.1	0.4	0.0	-0.3	0.6	0.3
Medication for cholesterol, blood pressure or diabetes	5.1	8.4	8.6	2.8	-2.9	2.9	-2.9
Glaucoma (self-reported)	0.1	0.2	0.3	-0.0	-0.5	0.4	-0.5
Gout (self-reported)	0.8	1.1	2.9	0.6	-1.7	0.8	-0.6
Hypothyroidism/myxoedema (self-reported)	0.5	0.9	1.3	0.8	-1.1	1.1	-0.7
Medication: Amlodipine	0.0	0.0	0.1	0.1	0.2	0.1	-0.3
Medication: Ventolin 100micrograms inhaler	0.0	0.0	0.1	-0.1	0.0	0.3	0.1
Birth weight	4.0	8.6	11.4	2.9	-2.6	3.4	-2.9
Chronic bronchitis/emphysema (mother)	1.0	1.1	1.7	-1.0	1.3	-0.7	1.2
High blood pressure (siblings)	0.3	0.4	0.9	0.1	-0.8	1.0	0.3
Forced vital capacity (FVC), Best measure	0.9	3.4	6.8	1.6	-2.6	1.7	-1.2
Body fat percentage	0.2	0.8	2.1	0.7	-0.7	1.4	-0.4
Leg fat percentage (right)	0.2	0.7	1.5	-0.9	0.6	-0.4	1.2
Arm fat-free mass (right)	0.1	0.5	1.3	-0.6	-0.2	-0.7	1.1
Exposure to tobacco smoke outside home	0.1	0.1	0.2	0.0	-0.2	0.5	0.2
Comparative body size at age 10	1.7	4.7	6.2	2.3	-2.5	2.1	-1.6
Number of full brothers	7.6	9.5	12.0	-2.9	2.8	-3.5	3.1
Worry too long after embarrassment	0.1	0.1	0.2	-0.5	0.5	0.1	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.6	2.0	2.5	-1.6	1.2	-1.4	1.5
Wheeze or whistling in the chest in last year	2.1	3.8	4.7	-2.2	1.9	-1.5	2.1
Number of children fathered	0.9	1.0	1.3	-1.2	0.1	-1.1	1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.2	-1.1	-0.4	-0.4	0.6
Age at first live birth	2.1	3.7	5.2	2.0	-2.3	2.0	-1.4
Pulse wave peak to peak time	1.3	1.5	2.9	1.7	-1.0	1.0	-1.0
Health satisfaction	1.9	2.5	2.8	1.7	-1.6	1.5	-1.6
Shortness of breath walking on level ground	1.7	2.0	2.2	1.5	-1.5	1.5	-1.2
Qualifications: College or University degree	2.8	8.7	9.9	2.8	-3.1	2.7	-3.1
Eye problems/disorders: None of the above	0.5	0.6	1.1	1.0	-0.6	1.1	-0.3
Mouth/teeth dental problems: Loose teeth	0.3	0.4	0.9	-0.8	0.3	-0.2	1.0
Emphysema/chronic bronchitis	0.8	0.9	2.4	-0.7	1.6	-0.4	0.7
Medication for pain relief, constipation, heartburn	0.1	0.1	0.4	-0.7	-0.0	-0.3	0.1
Neck or shoulder pain in last month	0.4	0.6	1.0	0.9	-1.0	0.7	-0.5
Medication: Blood pressure	4.2	7.5	7.8	-2.8	2.7	-2.7	2.8
Angina (self-reported)	0.0	0.0	0.0	0.1	-0.0	-0.2	0.2
Migraine (self-reported)	2.0	2.5	3.4	1.4	-1.5	1.8	-1.5
Medication: Ibuprofen	2.7	3.2	4.6	2.2	-1.3	1.9	-1.7
Medication: Allopurinol	1.1	1.4	4.6	0.4	-2.1	0.9	-0.3
Medication: Omeprazole	0.0	0.0	0.0	-0.0	0.2	0.1	0.1
Medication: Seretide 50 evohaler	0.4	0.5	0.8	-0.7	0.5	-0.9	0.8
Mean time to correctly identify matches	1.4	2.6	4.3	-1.7	2.1	-1.0	1.4
Heart disease (mother)	2.2	2.6	3.4	1.7	-1.3	1.9	-1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	10.9	13.0	15.5	-3.8	3.3	-3.9	3.4
Whole body fat mass	0.2	0.8	1.7	0.7	-0.9	1.3	-0.3
Leg fat mass (right)	0.1	0.2	0.7	-0.3	0.1	-0.0	0.8
Arm predicted mass (right)	0.1	0.5	1.3	-0.6	-0.2	-0.7	1.1
Pulse rate, automated reading	1.1	3.4	6.2	1.3	-1.6	2.5	-1.8
Alcohol intake frequency.	0.2	0.4	0.7	0.8	-0.2	0.9	-0.3
Comparative height size at age 10	0.1	0.8	1.2	0.9	-1.1	0.7	-0.9
Number of full sisters	4.1	5.0	7.5	-2.0	2.2	-1.8	2.7
Suffer from ‘nerves’	0.4	0.6	0.9	0.7	-0.9	0.9	-0.6
Overall health rating	0.1	0.2	0.3	0.6	0.3	0.5	-0.2
Chest pain or discomfort	2.3	3.4	3.7	-1.9	1.9	-1.8	1.7
Had major operations	0.3	0.4	0.5	-0.6	0.5	-0.7	0.6
Age at last live birth	0.5	0.7	1.3	1.1	-0.5	0.8	-0.9
Family relationship satisfaction	2.2	2.7	3.1	-1.6	1.6	-1.8	1.5
Leg pain on walking	1.1	1.3	2.9	0.9	-1.7	1.2	-0.5
Qualifications: NVQ or HND or HNC or equivalent	4.9	5.9	8.6	-1.9	2.9	-2.5	2.2
Commuting to job workplace: Car/motor vehicle	0.5	0.5	0.7	-0.8	0.6	-0.8	0.6
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	2.3	0.8	-1.5	1.5	-1.1
Medication: Aspirin	1.7	2.2	3.0	-1.2	1.7	-1.6	1.3
Supplements: Vitamin C	0.7	0.9	1.6	0.9	-0.6	0.9	-1.3
Knee pain experienced in last month	0.6	1.0	2.5	0.7	-1.6	0.8	-0.5
Hypertension (Self-reported)	1.5	4.2	6.2	-2.2	1.5	-1.8	2.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.0	-0.9	0.1	-1.0	0.8
Illnesses of father: Heart disease	0.3	0.4	0.5	-0.3	-0.7	0.7	0.6
Illnesses of siblings: Diabetes	0.1	0.1	0.2	0.1	-0.2	-0.5	-0.2
Smoking status: Previous	0.5	0.7	1.1	-1.0	1.0	-0.8	0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.3	0.5	-0.3	-0.1	-0.6
Whole body fat-free mass	0.2	1.0	2.4	0.9	-1.6	0.8	-0.2
Leg fat-free mass (right)	0.6	3.4	5.5	1.9	-2.4	1.8	-1.1
Arm fat percentage (left)	0.9	3.5	6.2	1.8	-1.7	2.5	-1.3
Average weekly red wine intake	0.1	0.1	0.3	-0.5	0.4	-0.2	0.3
Handedness (chirality/laterality): Left-handed	0.0	0.0	0.1	0.2	0.3	-0.2	-0.0
Mood swings	0.3	0.6	2.0	-0.2	1.4	-0.5	0.3
Loneliness, isolation	1.5	2.0	3.2	-1.2	1.8	-1.4	1.2
Long-standing illness, disability or infirmity	0.8	1.2	1.5	-1.2	1.1	-0.8	1.2
Ever had bowel cancer screening	0.2	0.3	0.6	-0.4	-0.4	0.8	0.3
Diabetes diagnosed by doctor	1.3	2.2	4.0	-0.9	1.9	-2.0	0.5
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.3	1.6	-1.0	1.0	-1.3	1.3
Friendships satisfaction	0.1	0.1	0.2	-0.4	-0.0	-0.0	0.4
Qualifications: nursing, teaching	0.3	0.4	1.1	0.5	-1.1	0.4	-0.3
Commuting to job workplace: Walk	0.5	0.5	0.9	0.9	-0.3	0.5	-0.9
Eye problems/disorders: Cataract	1.4	1.6	2.2	-1.4	0.7	-1.5	1.3
Mouth/teeth dental problems: Mouth ulcers	0.0	0.0	0.0	0.2	-0.2	0.1	0.1
Medication for cholesterol	0.2	0.3	0.5	0.7	0.3	0.4	-0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	4.5	5.3	7.5	2.0	-2.7	2.4	-2.0
Back pain experienced in last month	0.6	0.9	1.3	0.9	-1.1	1.1	-0.5
Mineral and other dietary supplements	0.2	0.3	0.8	0.6	0.9	0.1	-0.3
Breast cancer (self-reported)	3.9	4.7	5.2	-2.3	2.0	-2.3	2.0
Asthma (self-reported)	2.9	5.8	7.3	-2.7	2.7	-2.0	2.1
Osteoporosis (self-reported)	0.1	0.1	0.2	-0.2	0.4	-0.5	0.0
Osteoarthritis (self-reported)	1.0	1.3	3.9	0.5	-2.0	1.0	-0.4
Medication: Aspirin	2.5	3.2	4.3	-1.4	2.1	-2.0	1.6
Medication: Gliclazide	2.1	2.4	4.4	-1.3	2.1	-1.6	1.0
Illnesses of father: None of the above (group 1)	2.4	3.0	5.5	-1.5	1.6	-2.3	1.3
Smoking status: Current	2.7	4.3	5.9	-2.1	2.1	-1.6	2.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.4	6.7	1.0	-2.6	1.3	-0.5
Whole body water mass	0.2	0.9	2.4	0.9	-1.5	0.7	-0.2
Leg predicted mass (right)	0.7	3.8	6.1	2.0	-2.5	1.9	-1.2
Arm fat mass (left)	0.5	1.9	3.3	1.4	-1.4	1.8	-0.7
Number of self-reported non-cancer illnesses	1.0	1.7	3.1	-1.8	0.9	-0.9	1.5
Average weekly champagne plus white wine intake	1.1	1.5	1.8	1.3	-1.4	1.2	-1.2
Miserableness	3.5	6.1	8.7	-2.2	3.0	-2.4	2.1
Guilty feelings	2.3	3.4	5.3	-2.1	1.4	-1.4	2.3
Wears glasses or contact lenses	0.2	0.3	0.7	-0.2	-0.9	0.5	-0.3
Ever taken oral contraceptive pill	1.5	1.6	2.4	-1.1	1.5	-1.3	1.1
Hearing aid user	0.4	0.5	0.8	0.6	-0.6	0.9	-0.6
Mother’s age at death	0.0	0.1	0.1	0.2	-0.3	0.2	-0.2
Financial situation satisfaction	3.2	4.0	4.6	-2.0	1.7	-2.1	2.1
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.5	-0.2	-1.2	0.7	0.2
Commuting to job workplace: Public transport	1.8	2.1	3.0	1.4	-1.6	1.7	-0.9
Eye problems/disorders: Glaucoma	0.4	0.4	1.0	0.3	-0.5	0.6	-1.0
Medication: Blood pressure	0.2	0.3	0.5	-0.7	-0.7	0.0	0.6
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.3	0.1	-0.5	0.0	-0.2
Supplements: Fish oil (including cod liver oil)	0.2	0.3	1.0	-0.1	-1.0	0.2	-0.1
High cholesterol (Self-reported)	2.5	4.4	5.3	-2.3	1.7	-2.0	2.3
Medication: Bendroflumethiazide	0.2	0.3	0.6	-0.7	0.0	-0.1	0.8
Medication: Paracetamol	1.0	1.6	2.4	1.5	-0.8	1.1	-1.4
Medication: Lisinopril	0.0	0.0	0.0	-0.0	0.0	0.2	0.1
Medication: Atorvastatin	5.4	6.7	7.6	-2.5	2.8	-2.5	2.5
Illnesses of father: High blood pressure	0.2	0.3	0.4	0.7	-0.3	0.4	-0.5
Alcohol drinker status: Never	0.6	0.7	1.0	0.7	-0.8	0.7	-1.0
Ever smoked	0.5	0.9	1.2	-1.1	0.8	-0.9	1.1
Basal metabolic rate	0.2	1.0	2.2	1.0	-1.5	0.9	-0.3
Leg fat percentage (left)	0.2	0.7	1.4	-0.9	0.5	-0.4	1.2
Arm fat-free mass (left)	0.0	0.2	0.5	0.0	-0.4	-0.3	0.7
Number of operations (self-reported)	0.5	0.8	1.3	-1.2	0.3	-0.8	1.0
Average weekly beer plus cider intake	0.2	0.3	0.7	0.8	-0.4	0.3	-0.6
Irritability	0.2	0.3	0.6	-0.7	0.8	-0.1	0.3
Risk taking	2.5	3.6	4.3	-1.8	2.1	-1.7	1.9
Ever had prostate specific antigen (PSA) test	1.0	1.1	2.0	0.6	-1.3	1.4	-0.6
Fractured/broken bones in last 5 years	1.6	2.0	2.8	-1.2	1.7	-1.7	1.0
Age started oral contraceptive pill	1.8	2.3	3.3	1.5	-1.4	1.2	-1.8
Diastolic blood pressure, automated reading	1.0	3.1	4.0	1.7	-2.0	1.6	-1.8
Ever depressed for a whole week	1.1	1.3	2.1	-1.1	1.1	-1.0	1.4
Unable to work because of sickness or disability	0.3	0.4	0.7	-0.8	0.5	-0.2	0.9
Commuting to job workplace: Cycle	0.1	0.1	0.5	0.3	0.0	-0.1	-0.7
Myopia	1.2	1.7	2.3	-1.4	1.5	-1.3	1.0
Vascular/heart problems diagnosed by doctor	1.4	3.9	5.2	2.1	-1.5	2.0	-2.3
Cholesterol lowering medication	0.4	0.6	1.0	-1.0	0.4	-1.0	0.7
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.5	0.3	-0.6	0.7	-0.2
Pain experienced in last month	5.4	9.0	10.4	-3.0	2.9	-3.2	2.8
Supplements: Calcium	0.3	0.3	0.8	-0.9	0.4	-0.3	0.3
Basal cell carcinoma (self-reported)	2.9	3.4	6.8	1.3	-2.6	1.8	-1.4
Heart attack/myocardial infarction (self-reported)	0.7	0.9	2.0	-0.6	0.8	-1.4	0.7
Deep venous thrombosis (DVT) (self-reported)	2.1	2.7	3.6	-1.6	1.8	-1.9	1.1
Heart disease (siblings)	0.3	0.4	1.2	-0.0	1.1	-0.5	0.3
Alcohol drinker status: Previous	2.3	2.6	3.8	-2.0	0.9	-1.5	1.8
Pack years of smoking	0.1	0.1	0.2	0.3	0.3	0.4	-0.1
Impedance of whole body	0.2	1.0	2.9	-0.3	1.7	0.2	-0.9
Leg fat mass (left)	0.0	0.1	0.5	-0.2	0.0	0.1	0.7
Arm predicted mass (left)	0.0	0.2	0.7	-0.1	-0.3	-0.4	0.8