Hub : Genes

DAP3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0250	0.0140	2.0e-03	0.010	0.020	0.008	NA	0.014	2.0e-02	1.5e-03	3.6e-02	NA	7.1e-03
2	GTEx	Brain Cerebellar Hemisphere	0.1330	0.0700	4.1e-03	0.117	NA	0.111	NA	0.133	6.5e-04	NA	9.0e-04	NA	2.8e-04
3	GTEx	Skin Sun Exposed Lower leg	0.1820	0.0850	6.5e-03	0.003	NA	0.009	NA	0.012	1.8e-01	NA	5.4e-02	NA	3.1e-02
4	GTEx	Thyroid	0.1120	0.0410	5.3e-05	0.041	NA	0.034	NA	0.036	4.2e-04	NA	1.1e-03	NA	8.9e-04
5	METSIM	Adipose	0.0335	0.0158	4.7e-05	0.032	0.033	0.041	NA	0.033	1.1e-05	7.7e-06	8.3e-07	NA	9.9e-06
6	YFS	Blood	0.0157	0.0068	3.8e-07	0.028	0.021	0.023	NA	0.026	1.3e-09	1.2e-07	3.8e-08	NA	4.4e-09

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	2.6	4.1	5.9	2.4	2.2	0.0	-2.3	-2.0	-2.1
Bipolar Disorder or Schizophrenia	2.5	6.1	8.5	2.9	2.8	-1.7	-2.3	-2.2	-2.7
Depressed Affect (Nagel 2018)	1.5	3.1	6.8	1.9	1.9	0.2	-2.6	-1.0	-1.9
Depression (Nagel 2018)	2.8	4.2	6.1	1.9	1.7	-2.0	-2.1	-2.5	-2.0
Intelligence (Savage-Jansen 2018)	0.2	0.7	3.1	-0.5	-0.1	-1.8	0.8	-0.4	-0.2
Neuroticism (Nagel 2018)	0.3	0.6	1.5	0.4	1.2	-0.7	-0.1	0.3	-1.2
Schizophrenia (2018)	1.4	2.8	5.0	1.8	1.7	-2.2	-1.1	-1.2	-1.8
Schizophrenia vs Biploar Disorder	0.2	0.3	1.7	-0.3	-0.1	-1.3	-0.0	-0.2	0.2
Worry (Nagel 2018)	1.5	3.2	7.7	-1.9	-0.7	-0.3	2.8	2.6	0.9
Alzheimer’s Disease (in mother)	0.9	1.1	1.7	0.9	1.1	0.9	-0.6	-1.3	-1.2
Alzheimer’s Disease (in father)	1.1	1.2	2.1	-1.4	-1.0	1.4	0.7	0.6	1.1
Alzheimer’s Disease (including proxy)	0.2	0.3	0.8	0.0	0.4	0.9	-0.1	-0.8	-0.7
Crohns Disease (2017)	11.5	25.3	35.0	5.9	5.2	2.7	-4.9	-5.4	-5.3
Irritable Bowel Disease (IBD)	8.8	21.1	29.6	5.4	4.3	1.9	-5.2	-5.1	-4.6
Ulcerative Colitis (UC)	3.1	5.8	12.5	2.9	1.6	0.2	-3.5	-2.6	-2.1
Major Depression (MDD)	1.4	1.7	7.8	1.0	0.4	2.8	-0.5	-0.7	-0.6
Reaction Time	1.5	2.9	5.8	1.9	1.8	0.7	-1.1	-2.4	-1.8
Verbal and Numeric Reasoning (VNR)	0.3	0.8	1.5	-0.7	-1.2	-1.0	0.8	0.6	0.8
Breast Cancer	8.6	20.6	33.1	-5.2	-5.8	1.8	4.7	3.5	5.1
Ovarian Cancer	0.2	0.3	1.0	0.4	0.7	1.0	-0.0	-0.2	-0.5
Prostate Cancer	0.4	0.5	2.7	-0.1	0.4	-1.6	0.5	0.1	-0.1
Age at First Birth	1.8	2.6	11.4	-0.6	1.5	-3.4	0.8	0.7	-0.6
Bipolar Disorder (2011)	0.9	0.8	2.6	0.8	0.7	1.6	-1.0	-0.4	-0.5
Body Mass Index (BMI) (2010)	2.5	3.5	6.2	-2.4	-2.1	0.4	0.9	1.8	2.5
Coronary Artery Disease (CAD)	0.7	0.8	1.2	-0.8	-1.1	1.1	0.1	0.8	1.0
Crohns Disease (2012)	13.8	22.2	31.4	5.5	4.7	1.1	-5.6	-4.9	-4.9
Mean Putamen Volume	3.9	4.4	5.6	2.4	2.3	-1.2	-2.1	-2.2	-2.2
Fasting Glucose	0.6	0.7	1.2	1.1	0.6	-0.7	-1.1	-0.7	-0.8
HbA1C	0.2	0.2	0.7	0.1	-0.3	-0.4	-0.8	0.4	0.2
HDL Cholesterol	1.4	2.3	3.5	-1.7	-1.7	0.4	1.5	1.6	1.9
LDL Cholesterol	1.5	2.3	4.9	2.2	1.3	0.1	-1.8	-1.5	-1.4
Lupus	0.1	0.2	0.4	-0.3	-0.1	0.6	0.7	-0.5	0.3
Neuroticism (2016)	0.2	0.3	1.1	0.0	0.2	0.5	-0.4	-1.1	-0.6
Primary Biliary Cirrhosis	0.5	0.7	1.3	1.0	0.9	0.1	-1.0	-1.1	-0.7
Rheumatoid Arthritis	1.7	2.3	5.5	-0.8	-1.6	1.0	0.9	2.3	1.9
Schizophrenia (2014)	2.5	5.5	7.0	2.5	2.6	-2.3	-2.1	-1.7	-2.6
Triglycerides	0.6	1.0	2.4	0.8	0.7	-0.2	-0.9	-1.6	-1.2
Type 2 Diabetes (T2D) (2012)	0.6	0.6	1.4	1.2	0.4	-0.6	-1.1	-0.7	-0.6
Ulcerative Colitis	1.1	1.6	5.4	1.2	0.5	-0.1	-2.3	-1.5	-0.6
Blood Eosinophil Count	0.4	3.1	7.0	-1.8	-1.4	2.6	1.1	1.8	1.4
Blood Platelet Count	0.4	4.8	10.4	2.1	1.7	3.2	-2.8	-1.0	-1.2
Blood Red Count	0.1	1.4	3.9	0.2	-1.5	-0.3	-2.0	-1.5	-0.1
Blood White Count	1.1	8.1	20.8	2.4	1.9	4.6	-3.6	-1.5	-1.8
Heel T-Score	0.2	1.7	4.7	1.0	1.9	-0.0	0.0	-0.9	-2.2
BMI	0.6	3.7	7.5	-2.7	-2.3	1.7	0.1	0.3	2.6
Height	0.2	3.6	7.8	1.1	2.8	-2.2	1.0	0.7	-2.4
Waist Hip Ratio (WHR)	0.9	4.1	13.4	1.1	3.7	-0.8	-1.7	-0.4	-2.4
Systolic Blood Pressure	0.5	2.5	4.8	1.0	1.6	-2.2	-1.6	-1.0	-1.8
Smoking Status	1.7	4.0	6.8	2.3	2.3	0.4	-2.6	-1.6	-1.9
Allergy or Eczema	3.0	8.0	14.5	3.7	3.2	-0.6	-1.2	-2.7	-3.8
Cardiovascular Disease	2.2	7.2	13.3	2.7	2.7	-0.6	-3.6	-2.6	-2.9
Hypothyroidism (self reported)	0.3	0.6	1.7	-0.1	-1.0	-1.3	0.7	-0.6	0.0
Respiratory disease	1.9	4.3	7.5	2.7	2.3	2.3	-0.8	-1.6	-2.2
Type 2 Diabetes (T2D) (2018)	0.7	1.2	3.8	1.1	0.7	2.0	-1.4	-0.1	-0.4
Lung FEV1/FVC ratio	0.4	2.0	6.0	-0.2	0.1	-2.5	2.4	0.1	-0.3
Lung FVC	2.6	13.3	23.1	-3.6	-4.8	-0.8	4.0	3.7	3.6
Neuroticism	0.1	0.3	1.1	-0.1	1.1	0.5	-0.2	0.3	-0.7
Chronotype (morning person)	0.1	0.2	0.4	0.5	0.3	0.6	-0.5	-0.1	-0.3
Hair Pigment	0.9	26.7	44.5	6.7	4.3	1.8	-6.1	-5.7	-4.9
Tanning	1.6	19.7	31.0	4.3	4.6	-1.1	-5.6	-4.9	-4.8
Hand grip strength (left)	0.3	0.9	2.0	1.0	-0.2	-1.4	-1.1	-0.6	-0.9
Number of treatments/medications taken	0.2	0.4	1.0	0.4	0.7	0.7	-1.0	-0.3	-0.7
Average weekly spirits intake	0.1	0.1	0.3	0.4	0.1	-0.5	-0.2	0.1	-0.4
Sensitivity / hurt feelings	0.4	0.6	1.5	-1.1	0.2	-0.2	0.9	1.2	0.0
Frequency of depressed mood in last 2 weeks	3.8	5.3	7.2	2.4	2.1	-1.6	-2.3	-2.6	-2.7
Hearing difficulty/problems: Yes	0.1	0.2	0.8	-0.0	-0.2	-0.1	0.9	-0.6	-0.2
Relative age of first facial hair	0.3	0.6	1.1	0.6	1.1	-0.5	-1.0	-0.6	-0.5
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	1.7	1.1	1.3	-0.2	-0.1	-1.0	-1.3
Ever used hormone-replacement therapy (HRT)	0.8	1.0	2.1	-1.1	-1.4	-1.0	0.5	0.2	1.2
Ever had hysterectomy (womb removed)	0.3	0.4	1.1	-0.6	-0.6	-0.1	1.1	-0.2	0.5
Systolic blood pressure, automated reading	0.1	0.2	0.6	-0.4	-0.1	-0.8	-0.6	-0.6	0.1
Eye problems/disorders: Diabetes related eye disease	0.7	0.7	1.1	-1.0	-0.7	0.9	0.6	1.1	0.8
Angina	0.1	0.2	0.7	-0.2	-0.2	0.2	-0.5	-0.8	-0.2
Medication for hormone replacement therapy	0.2	0.3	0.9	-0.0	-0.4	-1.0	0.3	-0.6	-0.1
Vitamin and mineral supplements	0.5	0.6	1.6	0.4	0.4	-0.8	-1.3	-1.0	-0.4
Supplements: Zinc	1.4	1.5	3.2	-0.6	-1.8	1.5	1.2	0.7	1.1
Medication: Co-codamol	0.2	0.2	0.6	-0.1	-0.8	0.6	-0.4	-0.2	0.4
Medication: Metformin	0.2	0.3	1.2	0.3	0.2	0.7	-1.1	0.0	0.0
Diabetes (father)	0.4	0.4	1.0	0.8	0.4	0.2	-0.6	-1.0	-0.7
Diabetes (mother)	0.9	1.2	2.4	0.5	1.3	-0.3	-1.5	-1.4	-0.8
Severe depression (siblings)	2.9	3.2	5.9	1.5	2.0	-0.0	-2.4	-2.2	-1.6
Pack years adult smoking proportion	0.6	0.9	2.4	0.3	0.3	1.5	0.1	-1.4	-1.0
Impedance of leg (right)	3.1	14.9	32.7	4.6	5.7	-1.0	-2.1	-1.8	-5.2
Leg fat-free mass (left)	1.0	5.4	9.4	-3.1	-2.9	-1.1	2.1	1.7	2.5
Trunk fat percentage	0.4	1.8	4.0	-1.6	1.7	0.3	2.0	1.1	-0.2
Hand grip strength (right)	0.1	0.2	0.6	0.3	-0.5	-0.7	-0.3	0.1	-0.2
Townsend deprivation index at recruitment	2.4	3.3	10.4	1.4	0.1	3.2	-2.4	-1.2	-0.7
Current tobacco smoking	3.0	5.0	7.2	2.7	2.5	1.1	-2.1	-2.3	-2.3
Average weekly fortified wine intake	0.2	0.2	0.6	0.6	0.3	0.4	-0.1	-0.8	-0.4
Maternal smoking around birth	1.6	2.3	5.9	1.4	1.7	-0.5	-2.4	-0.6	-1.5
Fed-up feelings	0.8	1.5	3.2	1.3	1.1	1.0	-1.8	-1.1	-1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	2.2	2.9	5.1	1.4	1.2	-1.6	-2.2	-2.0	-1.6
Relative age voice broke	1.1	1.7	2.6	1.6	1.1	-1.0	-1.2	-1.4	-1.4
Taking other prescription medications	0.1	0.2	0.7	0.2	0.3	0.8	-0.2	-0.2	-0.5
Age when periods started (menarche)	0.7	1.7	2.7	0.8	1.4	-1.2	-1.4	-1.7	-1.3
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	3.0	0.1	-0.0	-0.3	0.3	-1.7	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	2.6	0.3	1.2	0.2	0.4	-1.6	-1.5
Tinnitus: Yes, but not now, but have in the past	3.5	3.7	5.3	-1.6	-2.3	1.4	2.0	2.2	2.0
Qualifications: CSEs or equivalent	2.1	2.7	4.6	2.1	1.7	-0.0	-2.1	-1.0	-1.9
Serious illness, injury or assault to yourself	0.8	1.0	2.1	0.3	1.3	-1.5	-1.1	-0.4	-0.8
High blood pressure	1.1	3.1	4.6	1.2	1.8	-1.5	-1.9	-2.1	-1.9
Hayfever, allergic rhinitis or eczema	2.9	6.3	11.6	3.4	3.2	-0.3	-1.3	-1.8	-3.3
Multivitamins +/- minerals	0.4	0.6	1.4	-0.1	-0.5	0.9	1.2	0.9	0.1
Stomach or abdominal pain in last month	0.4	0.5	0.8	-0.7	-0.8	0.9	0.8	0.4	0.2
Supplements: Glucosamine	0.5	0.7	2.1	-0.8	-0.9	-1.5	0.6	-0.2	0.4
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	3.2	-1.1	-0.5	-0.5	1.8	1.0	0.8
Medication: Atenolol	0.2	0.3	1.4	0.2	0.6	-0.2	-1.2	-0.1	-0.3
Medication: Levothyroxine sodium	0.8	1.4	5.2	-0.9	-1.2	-2.3	0.4	0.5	0.8
Sitting height	0.2	1.6	6.4	0.4	0.9	-2.5	0.9	0.8	-0.7
Chronic bronchitis/emphysema (father)	0.9	1.1	2.5	-0.9	-1.1	1.6	0.1	0.4	1.3
High blood pressure (mother)	3.0	4.2	8.6	-2.9	-2.0	-1.1	1.4	1.7	2.5
Body mass index (BMI)	0.7	3.0	7.1	-2.7	-2.3	0.1	0.7	0.3	2.2
Impedance of leg (left)	3.2	15.5	34.9	4.7	5.9	-0.4	-2.4	-1.9	-5.1
Leg predicted mass (left)	1.1	5.8	10.0	-3.2	-3.0	-1.0	2.2	1.8	2.6
Trunk fat mass	0.3	1.4	3.7	-1.8	0.8	-0.2	1.9	1.1	0.3
Waist circumference	0.0	0.1	0.4	-0.7	0.3	-0.3	-0.4	-0.2	-0.1
Number of incorrect matches in round	0.7	1.2	5.4	-0.5	0.7	-2.3	0.4	-0.7	-0.5
Past tobacco smoking	0.5	1.0	3.4	-1.2	-0.4	0.4	1.9	0.7	0.6
Alcohol usually taken with meals	0.4	0.7	3.3	-0.1	0.6	-1.8	0.5	0.5	-0.3
Nervous feelings	3.4	6.3	10.9	-3.0	-1.9	0.6	2.9	3.3	2.5
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.5	3.4	1.0	1.1	-0.7	-0.7	-1.9	-1.6
Hearing difficulty/problems with background noise	0.2	0.3	0.9	-0.6	-0.6	-0.9	0.1	-0.1	0.2
Hair/balding pattern: Pattern 2	4.0	5.0	11.8	2.4	2.0	0.7	-3.4	-2.1	-1.9
Had menopause	0.5	0.6	1.6	-1.3	-0.5	-0.4	0.1	-0.7	1.1
Had other major operations	1.6	1.9	3.8	1.0	1.6	-0.5	-0.8	-1.9	-1.8
Forced vital capacity (FVC)	1.1	4.3	7.0	-1.6	-2.3	-1.9	2.6	2.4	1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.7	4.2	1.0	1.7	0.3	0.0	-1.4	-2.0
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.5	-0.1	-0.7	-0.4	-0.1	-0.0	0.1
Qualifications: None of the above	0.4	0.8	1.3	-1.1	-1.0	0.6	-0.9	-0.6	1.0
Financial difficulties in last 2 years	0.8	1.1	2.7	-1.2	-1.6	0.3	-0.2	0.0	1.6
Mouth/teeth dental problems	1.6	2.4	5.7	-1.3	-0.9	-1.3	2.4	1.8	1.1
Heart attack	1.6	2.1	5.3	0.7	-0.2	2.3	-1.9	-1.6	-0.4
Allergy	2.7	6.1	12.2	-3.5	-2.8	-1.5	1.1	1.9	3.0
Pain all over the body in last month	2.8	3.0	4.9	-2.2	-2.2	0.8	1.8	0.9	1.9
Diabetes (self-reported)	0.9	1.3	3.8	0.8	1.5	0.5	-1.9	-0.5	-0.9
Hayfever/allergic rhinitis (self-reported)	1.4	1.9	4.7	2.2	1.3	0.4	-0.0	-1.2	-1.8
Medication: Ramipril	9.5	12.2	15.1	3.1	3.9	-3.2	-3.7	-3.4	-3.7
Medication: Simvastatin	0.2	0.2	1.3	0.0	0.2	0.1	-1.1	-0.3	-0.1
Fluid intelligence score	0.0	0.0	0.1	0.2	-0.4	-0.1	0.2	-0.0	-0.1
Illnesses of siblings	0.4	0.6	1.5	-0.1	-0.5	1.0	1.2	0.8	-0.0
Neuroticism score	0.1	0.3	0.6	0.2	0.8	0.8	-0.1	0.3	-0.7
Weight	0.3	1.6	4.2	-2.1	-1.3	-0.9	1.1	0.6	1.2
Impedance of arm (right)	1.6	7.4	19.7	0.2	4.4	0.5	3.2	3.3	-1.9
Arm fat percentage (right)	1.0	4.0	9.6	-3.1	-0.6	0.5	2.4	2.1	1.8
Trunk fat-free mass	0.7	4.0	11.3	-1.6	-3.4	-2.4	0.4	0.3	2.0
Hip circumference	0.2	1.1	2.0	-1.3	-1.4	-1.1	0.7	0.1	0.9
Time employed in main current job	2.1	2.4	5.1	-2.0	-1.7	0.8	1.1	0.9	2.3
Alcohol intake versus 10 years previously	0.8	1.2	2.4	0.9	0.2	1.6	-1.2	-1.3	-0.9
Father’s age at death	1.1	1.5	3.4	-0.8	-0.8	1.0	1.3	1.8	1.2
Worrier / anxious feelings	2.9	5.5	9.2	-2.8	-1.7	0.4	2.7	3.0	2.4
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.8	4.0	1.2	0.8	0.2	-1.2	-2.0	-1.8
Falls in the last year	0.5	0.6	1.4	1.2	0.3	1.1	-0.1	-0.7	-0.8
Hair/balding pattern: Pattern 3	1.2	1.8	3.2	-1.3	-1.1	-1.0	1.5	1.8	1.1
Number of live births	0.4	0.5	1.2	0.6	0.3	0.1	-1.1	-1.0	-0.6
Forced expiratory volume in 1-second (FEV1)	1.3	4.5	8.9	-1.4	-1.9	-2.7	3.0	2.1	0.8
Pulse rate	0.3	0.5	1.0	0.8	0.1	1.0	0.5	-0.8	-0.7
Happiness	0.1	0.2	0.4	0.2	0.3	-0.5	-0.3	-0.1	-0.6
Noisy workplace	0.2	0.2	0.5	0.1	-0.2	0.4	-0.1	-0.6	0.7
Qualifications: A levels/AS levels or equivalent	0.6	1.3	3.2	-0.5	-1.0	0.4	1.8	1.5	0.8
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	1.5	1.2	0.4	0.5	-0.2	0.1	-0.7
Mouth/teeth dental problems: Dentures	2.2	3.6	11.2	1.5	1.4	0.9	-3.3	-2.0	-1.1
Asthma	2.2	4.4	9.5	2.7	2.1	3.1	-1.4	-0.9	-1.7
Medication: Ibuprofen (e.g. Nurofen)	5.1	6.4	10.7	-2.8	-3.3	-0.7	2.1	2.7	2.7
Medication: Cholesterol lowering	0.8	1.3	3.8	1.1	0.9	-0.7	-1.9	-1.0	-0.8
Depression (self-reported)	0.5	0.6	1.3	1.2	1.0	0.1	0.1	-0.4	-1.0
Medication: Lansoprazole	0.5	0.6	2.1	0.6	-0.4	1.4	-0.6	-0.8	-0.3
Prospective memory result	0.3	0.3	1.3	-0.2	0.4	0.6	1.1	0.3	0.1
Lung cancer (father)	0.5	0.6	0.9	0.9	0.5	1.0	-0.4	-0.9	-0.9
Illnesses of mother	0.9	1.1	3.0	1.7	0.1	0.6	-0.9	-0.9	-1.3
Forced expiratory volume in 1-second (FEV1), Best measure	1.6	5.1	9.4	-1.6	-2.1	-2.8	3.1	2.2	1.1
Pulse wave Arterial Stiffness index	1.7	2.0	3.2	1.7	1.8	-0.4	-1.1	-1.4	-1.7
Impedance of arm (left)	1.6	7.6	22.6	0.4	4.8	1.1	3.1	2.4	-2.4
Arm fat mass (right)	0.8	3.3	8.6	-2.9	-1.4	-0.2	1.9	1.4	1.9
Trunk predicted mass	0.7	4.0	11.3	-1.6	-3.4	-2.4	0.4	0.3	2.0
Standing height	0.3	2.7	7.0	0.8	1.9	-2.6	1.1	0.8	-1.7
Length of working week for main job	0.2	0.2	0.3	-0.5	-0.4	0.5	0.0	-0.2	0.6
Exposure to tobacco smoke at home	0.5	0.6	1.8	-0.7	-1.3	0.4	0.4	0.6	0.8
Breastfed as a baby	1.2	1.5	3.1	1.3	1.5	0.2	-1.8	-1.1	-1.0
Tense / ‘highly strung’	1.3	2.1	4.0	1.6	1.5	-0.8	-0.3	-1.7	-2.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.6	0.4	0.5	-0.4	-0.1	-0.6	-0.8
Hair/balding pattern: Pattern 4	1.0	2.5	6.0	-1.6	-1.2	-0.9	2.4	1.7	1.2
Birth weight of first child	1.4	2.6	5.2	-1.1	0.2	2.0	2.0	2.3	1.1
Peak expiratory flow (PEF)	1.2	2.9	7.0	-1.4	-0.7	-2.6	1.9	2.0	0.7
Pulse wave reflection index	1.5	1.8	3.1	1.3	1.8	-0.5	-1.6	-0.9	-1.6
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.5	0.4	0.1	0.7	0.4	0.1	-0.5
Loud music exposure frequency	1.7	1.9	3.0	-1.6	-1.3	0.2	1.7	1.4	1.4
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.7	-0.3	-0.4	-0.8	1.3	1.0	0.3
Mouth/teeth dental problems: Bleeding gums	1.5	1.9	7.9	1.1	0.3	2.8	-1.3	-0.7	-0.3
Blood clot in the leg (DVT)	1.6	2.0	3.3	1.2	0.7	1.8	-1.6	-1.8	-1.0
Medication: Paracetamol	1.2	2.1	3.6	-1.7	-1.9	1.1	0.7	1.4	1.5
Headache pain in last month	0.3	0.4	1.3	-0.3	-0.5	0.4	1.1	0.9	-0.0
Medication for cholesterol, blood pressure or diabetes	4.1	6.8	10.0	-2.6	-2.6	0.9	3.2	2.9	2.8
Glaucoma (self-reported)	0.4	0.4	1.3	0.4	0.6	-0.6	0.4	1.1	-0.5
Gout (self-reported)	0.2	0.3	1.3	-0.3	-0.1	-0.3	1.1	-0.2	-0.4
Hypothyroidism/myxoedema (self-reported)	0.8	1.6	3.8	-1.3	-1.9	-1.4	0.9	0.3	1.2
Medication: Amlodipine	0.3	0.4	1.5	0.0	-0.0	-1.2	0.3	-0.3	-0.7
Medication: Ventolin 100micrograms inhaler	1.0	1.3	7.1	0.4	0.5	2.7	-0.3	0.0	-0.2
Birth weight	4.6	10.0	14.0	-3.7	-2.2	2.6	2.8	3.7	3.5
Chronic bronchitis/emphysema (mother)	0.7	0.8	2.6	0.5	0.4	0.4	-1.1	-1.6	-0.5
High blood pressure (siblings)	0.2	0.4	0.7	-0.8	0.2	-0.8	0.6	0.5	0.5
Forced vital capacity (FVC), Best measure	1.2	4.5	7.5	-1.7	-2.2	-2.2	2.7	2.3	1.2
Body fat percentage	0.3	1.0	2.1	-1.4	1.2	0.3	1.4	0.7	-0.1
Leg fat percentage (right)	0.1	0.4	0.9	-0.0	0.9	-0.2	-0.5	-0.9	-0.8
Arm fat-free mass (right)	0.4	2.0	5.5	-0.8	-2.4	-1.9	-0.7	-1.0	1.0
Exposure to tobacco smoke outside home	0.6	0.8	2.2	0.5	0.8	-1.5	0.2	-0.2	-1.3
Comparative body size at age 10	2.6	7.0	12.7	-3.0	-2.9	3.6	1.1	1.3	3.0
Number of full brothers	5.9	7.4	11.0	3.1	2.5	-0.1	-2.9	-3.3	-3.1
Worry too long after embarrassment	0.2	0.4	1.1	0.5	0.5	-0.6	-0.1	-0.6	-1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	2.4	3.1	5.2	2.2	1.9	0.8	-1.0	-1.9	-2.3
Wheeze or whistling in the chest in last year	1.6	2.8	7.1	1.9	1.1	0.7	-1.7	-2.7	-1.2
Number of children fathered	1.2	1.4	3.0	1.6	0.6	-0.8	-0.6	-1.7	-1.2
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	2.5	1.1	1.6	-1.0	-0.7	-0.9	-1.5
Age at first live birth	2.3	4.0	8.5	-1.8	-1.4	-1.8	1.9	2.9	1.8
Pulse wave peak to peak time	1.7	2.0	2.8	-1.7	-1.7	0.1	1.3	1.5	1.6
Health satisfaction	0.9	1.2	2.9	-1.0	-1.7	0.6	1.4	0.7	0.5
Shortness of breath walking on level ground	1.2	1.5	3.5	-1.0	-1.9	0.9	1.3	0.9	1.1
Qualifications: College or University degree	1.7	5.5	14.2	-1.8	-2.3	-1.5	3.8	2.2	1.8
Eye problems/disorders: None of the above	0.9	1.1	2.3	-1.5	-0.8	-1.2	0.7	0.5	1.1
Mouth/teeth dental problems: Loose teeth	0.7	0.8	2.1	0.9	0.8	0.6	-0.3	-1.0	-1.4
Emphysema/chronic bronchitis	1.3	1.4	3.9	0.9	0.2	2.0	-0.5	-1.8	-0.7
Medication for pain relief, constipation, heartburn	0.7	1.2	2.6	1.4	1.6	0.6	0.0	-1.1	-1.1
Neck or shoulder pain in last month	0.9	1.3	4.3	-1.3	-2.1	-0.5	0.4	0.1	1.2
Medication: Blood pressure	3.8	6.8	9.1	2.2	2.6	-2.3	-3.0	-2.5	-2.8
Angina (self-reported)	0.2	0.2	0.7	-0.4	-0.6	-0.2	-0.4	-0.8	0.1
Migraine (self-reported)	1.8	2.3	3.8	-1.3	-1.4	-0.3	1.9	2.0	1.5
Medication: Ibuprofen	4.4	5.3	8.2	-2.5	-2.9	-0.3	2.1	2.6	2.4
Medication: Allopurinol	0.2	0.3	1.1	-0.5	-0.3	0.0	1.1	0.6	-0.0
Medication: Omeprazole	0.2	0.2	1.0	-0.3	-0.2	-1.0	-0.1	-0.2	-0.0
Medication: Seretide 50 evohaler	0.2	0.2	0.8	0.3	0.1	0.6	-0.9	0.2	0.4
Mean time to correctly identify matches	1.3	2.4	6.1	1.4	1.7	0.6	-1.1	-2.5	-1.5
Heart disease (mother)	3.1	3.7	5.8	-2.1	-1.8	2.4	1.1	1.6	2.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	6.2	7.4	14.4	2.8	2.9	-1.4	-3.8	-2.3	-2.6
Whole body fat mass	0.3	1.1	3.7	-1.9	0.1	-0.4	1.4	0.8	0.6
Leg fat mass (right)	0.0	0.2	0.9	-0.9	0.2	-0.2	-0.0	-0.3	0.1
Arm predicted mass (right)	0.4	1.9	5.4	-0.7	-2.3	-1.8	-0.7	-1.0	1.0
Pulse rate, automated reading	0.5	1.6	3.7	-1.3	-1.0	1.4	1.9	0.3	0.9
Alcohol intake frequency.	0.4	1.0	2.2	-1.5	-1.1	1.4	0.4	0.0	0.8
Comparative height size at age 10	0.1	0.6	1.9	-0.7	0.5	-0.3	1.4	0.8	-0.4
Number of full sisters	2.0	2.5	5.6	0.9	1.0	-2.4	-2.1	-1.3	-1.2
Suffer from ‘nerves’	0.2	0.3	1.0	-0.6	-0.2	-0.2	0.6	1.0	0.1
Overall health rating	0.3	0.5	1.0	-1.0	-1.0	0.8	0.3	0.1	0.7
Chest pain or discomfort	3.6	5.2	10.8	2.4	1.5	2.2	-2.1	-3.3	-1.9
Had major operations	0.3	0.4	0.5	0.7	0.6	0.7	-0.7	0.6	-0.5
Age at last live birth	1.7	2.5	8.0	-1.0	-0.5	-2.8	1.2	1.8	1.0
Family relationship satisfaction	2.3	2.9	4.2	1.8	1.8	-0.2	-2.0	-1.6	-2.1
Leg pain on walking	1.0	1.3	3.3	-1.2	-1.8	0.9	0.8	0.5	1.1
Qualifications: NVQ or HND or HNC or equivalent	1.7	2.0	7.3	1.5	1.1	0.4	-2.7	-0.5	-0.8
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.6	0.3	0.1	-0.2	-0.6	-0.8	-0.1
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	2.2	0.1	0.1	-0.2	1.5	1.0	-0.3
Medication: Aspirin	1.4	1.9	4.9	0.8	1.3	-1.3	-2.2	-1.1	-1.0
Supplements: Vitamin C	1.0	1.2	2.6	-1.6	-1.2	0.4	0.2	0.5	1.6
Knee pain experienced in last month	0.5	0.8	2.0	-0.6	-1.4	-0.1	1.2	0.6	0.7
Hypertension (Self-reported)	1.6	4.4	6.4	1.6	2.5	-1.4	-2.3	-2.2	-2.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	0.8	0.8	0.2	-0.4	-0.5	-0.1	-0.9
Illnesses of father: Heart disease	1.6	2.2	10.6	-1.3	0.6	-3.3	0.2	-0.7	0.2
Illnesses of siblings: Diabetes	0.2	0.3	0.7	-0.3	-0.7	-0.1	-0.8	-0.4	0.4
Smoking status: Previous	0.6	0.9	3.7	1.1	0.3	0.2	-1.9	-0.1	-0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	1.5	-0.2	-0.8	-1.2	0.4	0.7	0.2
Whole body fat-free mass	0.7	4.3	10.8	-2.2	-3.3	-1.9	0.9	0.8	2.2
Leg fat-free mass (right)	1.1	5.9	10.1	-3.2	-3.2	-0.8	2.0	1.7	2.7
Arm fat percentage (left)	0.8	3.3	8.2	-2.9	-0.3	0.7	2.5	1.7	1.4
Average weekly red wine intake	0.9	1.3	4.2	0.9	1.1	-2.0	-0.5	-0.5	-1.0
Handedness (chirality/laterality): Left-handed	0.3	0.3	1.5	0.0	0.1	-1.2	-0.2	-0.6	-0.4
Mood swings	0.2	0.4	1.0	0.5	0.9	-0.1	-1.0	0.0	-0.7
Loneliness, isolation	1.3	1.8	2.9	1.5	1.1	0.0	-1.5	-1.7	-1.4
Long-standing illness, disability or infirmity	1.0	1.6	2.5	0.8	1.6	1.3	-0.9	-1.4	-1.4
Ever had bowel cancer screening	0.1	0.1	0.3	0.3	0.5	0.1	-0.1	0.5	-0.5
Diabetes diagnosed by doctor	0.9	1.4	2.8	1.0	1.1	1.5	-1.7	-0.8	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	1.5	1.2	1.0	1.0	-0.7	-0.7	-1.1
Friendships satisfaction	0.4	0.5	1.2	0.7	0.5	-0.9	-0.2	0.5	-1.1
Qualifications: nursing, teaching	0.1	0.2	0.3	-0.3	-0.5	0.1	0.5	-0.5	0.4
Commuting to job workplace: Walk	0.7	0.7	1.8	-0.4	-0.7	1.3	0.6	0.9	0.9
Eye problems/disorders: Cataract	1.0	1.2	2.7	1.6	0.7	0.3	-1.0	-1.4	-1.0
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.7	0.3	-0.4	-0.0	-0.1	-0.9	-0.7
Medication for cholesterol	0.6	0.9	1.4	-0.6	-0.8	1.2	1.2	0.6	1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.8	3.3	8.5	-1.9	-1.5	0.0	2.9	1.8	1.5
Back pain experienced in last month	1.2	1.8	6.4	-1.1	-0.9	-2.5	1.3	0.8	0.3
Mineral and other dietary supplements	0.4	0.6	2.3	-0.2	0.3	1.5	0.2	0.9	0.4
Breast cancer (self-reported)	3.1	3.7	5.8	1.7	2.1	-0.0	-2.2	-2.4	-2.0
Asthma (self-reported)	2.7	5.3	10.8	2.9	2.3	3.3	-1.4	-1.2	-2.0
Osteoporosis (self-reported)	0.1	0.1	0.2	0.5	0.1	0.3	-0.5	-0.4	-0.2
Osteoarthritis (self-reported)	1.0	1.3	2.7	-1.2	-1.6	-0.9	0.9	0.7	1.2
Medication: Aspirin	1.8	2.4	7.2	0.7	1.3	-1.4	-2.7	-1.4	-1.0
Medication: Gliclazide	1.8	2.0	4.6	1.1	1.2	2.1	-2.1	0.2	-0.5
Illnesses of father: None of the above (group 1)	1.4	1.7	4.2	2.1	1.2	-0.4	-1.3	-0.2	-1.6
Smoking status: Current	1.9	3.0	4.2	2.1	2.0	0.8	-1.4	-2.0	-1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.8	4.7	-1.1	-1.0	-1.6	2.2	1.0	0.1
Whole body water mass	0.7	4.2	10.9	-2.2	-3.3	-1.8	0.9	0.7	2.3
Leg predicted mass (right)	1.1	6.1	10.3	-3.2	-3.2	-0.7	2.1	1.8	2.8
Arm fat mass (left)	0.6	2.7	7.4	-2.7	-1.1	-0.3	1.9	1.1	1.6
Number of self-reported non-cancer illnesses	1.2	2.1	3.1	1.6	1.6	1.2	-0.8	-1.5	-1.8
Average weekly champagne plus white wine intake	1.4	2.0	4.3	-1.1	-0.7	-1.8	2.1	1.4	0.8
Miserableness	2.0	3.5	7.8	2.3	1.8	0.2	-2.8	-0.8	-2.1
Guilty feelings	2.4	3.6	6.6	1.8	1.8	-1.8	-1.2	-1.9	-2.6
Wears glasses or contact lenses	0.4	0.5	1.5	-0.1	1.2	-0.1	0.1	1.2	-0.1
Ever taken oral contraceptive pill	0.9	1.0	2.3	1.5	0.6	1.2	-1.0	-0.4	-0.9
Hearing aid user	0.5	0.5	1.1	-0.8	-1.0	0.4	1.0	0.1	0.7
Mother’s age at death	0.8	1.0	4.0	-1.1	-0.3	-2.0	0.6	0.4	0.6
Financial situation satisfaction	2.1	2.6	5.8	2.0	1.3	0.2	-2.4	-1.4	-1.4
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.7	0.2	0.6	-0.0	-0.0	0.4	-0.8
Commuting to job workplace: Public transport	2.0	2.4	3.7	-1.8	-1.2	0.6	1.7	1.7	1.9
Eye problems/disorders: Glaucoma	0.6	0.7	3.6	-0.1	0.5	0.3	0.4	1.9	0.0
Medication: Blood pressure	0.6	1.1	1.6	0.5	1.0	-1.1	-1.0	-1.2	-1.3
Pain type(s) experienced in last month: Hip pain	0.5	0.6	2.8	0.5	-0.3	0.7	-0.1	-1.7	-0.3
Supplements: Fish oil (including cod liver oil)	0.2	0.3	1.1	0.2	-0.1	-1.1	0.3	-0.4	-0.2
High cholesterol (Self-reported)	1.8	3.1	10.8	1.5	0.9	1.0	-3.3	-1.8	-0.9
Medication: Bendroflumethiazide	0.3	0.4	1.2	0.4	0.4	-0.2	-1.1	-0.6	-0.7
Medication: Paracetamol	1.5	2.3	3.0	-1.7	-1.7	1.7	0.8	1.6	1.4
Medication: Lisinopril	0.2	0.3	0.8	-0.9	-0.2	-0.3	-0.6	0.2	0.5
Medication: Atorvastatin	4.1	5.1	14.1	2.2	1.6	0.9	-3.8	-2.3	-1.7
Illnesses of father: High blood pressure	0.4	0.5	1.8	-0.2	-1.4	-0.7	0.5	0.0	0.5
Alcohol drinker status: Never	0.2	0.2	0.6	-0.3	-0.8	0.1	0.7	-0.2	0.0
Ever smoked	0.5	0.8	2.8	0.9	0.2	-0.6	-1.7	-0.8	-0.5
Basal metabolic rate	0.7	3.8	8.6	-2.3	-2.9	-1.6	1.1	0.8	2.1
Leg fat percentage (left)	0.1	0.4	0.8	-0.1	0.9	0.2	-0.5	-0.9	-0.6
Arm fat-free mass (left)	0.6	3.1	9.1	-1.5	-3.0	-1.9	-0.3	-0.5	1.8
Number of operations (self-reported)	0.6	0.9	2.3	0.9	0.5	1.5	-0.9	-0.8	-0.8
Average weekly beer plus cider intake	1.0	1.4	3.6	-0.7	-1.9	1.1	-0.0	0.2	1.8
Irritability	0.7	1.1	2.1	1.1	1.2	1.4	-0.7	-0.2	-1.2
Risk taking	1.9	2.7	4.5	2.1	1.5	-1.1	-1.3	-1.7	-2.0
Ever had prostate specific antigen (PSA) test	1.0	1.2	2.1	-1.1	-0.8	-0.6	1.5	1.4	0.9
Fractured/broken bones in last 5 years	1.0	1.3	3.1	1.8	0.8	0.5	-1.3	-1.0	-1.2
Age started oral contraceptive pill	1.0	1.3	2.6	-1.6	-0.7	0.8	0.6	1.1	1.6
Diastolic blood pressure, automated reading	0.5	1.7	3.7	-1.9	-1.6	-0.7	1.1	0.6	1.3
Ever depressed for a whole week	0.9	1.1	1.8	1.2	1.1	-0.5	-0.7	-1.1	-1.3
Unable to work because of sickness or disability	0.6	0.8	2.3	0.7	0.0	1.5	-0.3	-1.4	-0.4
Commuting to job workplace: Cycle	0.2	0.3	1.1	-0.4	-0.2	-1.1	0.5	-0.1	0.2
Myopia	1.8	2.6	4.0	2.0	1.9	-1.7	-1.0	-0.4	-1.9
Vascular/heart problems diagnosed by doctor	1.5	4.1	6.5	-1.6	-1.9	0.6	2.5	2.5	2.2
Cholesterol lowering medication	0.8	1.1	3.1	0.8	0.3	1.6	-1.8	-0.5	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.3	-0.5	-0.2	-0.4	0.5	0.2	0.0
Pain experienced in last month	5.4	9.1	15.2	3.2	3.9	0.3	-3.4	-2.7	-3.1
Supplements: Calcium	0.3	0.3	0.6	0.5	0.6	0.7	-0.8	-0.5	-0.1
Basal cell carcinoma (self-reported)	1.3	1.6	3.1	-1.4	-1.0	0.0	1.8	1.4	1.3
Heart attack/myocardial infarction (self-reported)	1.6	2.0	6.2	0.5	-0.5	2.5	-1.8	-1.5	-0.2
Deep venous thrombosis (DVT) (self-reported)	1.8	2.3	4.0	1.3	0.8	1.9	-1.6	-2.0	-1.2
Heart disease (siblings)	0.7	0.8	1.3	-0.7	-1.0	1.1	-0.9	-0.1	1.1
Alcohol drinker status: Previous	2.1	2.4	3.4	1.8	1.7	0.3	-1.7	-1.3	-1.9
Pack years of smoking	0.6	0.8	2.4	0.3	0.4	1.6	0.1	-1.2	-0.9
Impedance of whole body	1.9	9.5	33.2	2.6	5.8	0.2	0.7	0.5	-4.0
Leg fat mass (left)	0.1	0.2	1.1	-1.0	0.1	0.0	0.1	-0.1	0.2
Arm predicted mass (left)	0.6	2.9	8.4	-1.4	-2.9	-2.0	-0.5	-0.4	1.7