TWAS hub - HCN3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adrenal Gland	0.1322	0.0713	6.5e-03	0.085	NA	0.015	NA	0.050	5.5e-04	NA	9.1e-02	NA	7.1e-03
2	GTEx	Artery Coronary	0.1740	0.0860	7.1e-03	-0.007	NA	-0.008	NA	-0.008	6.2e-01	NA	8.4e-01	NA	7.4e-01
3	GTEx	Artery Tibial	0.1688	0.0624	1.7e-05	0.012	NA	0.013	NA	0.014	3.8e-02	NA	3.0e-02	NA	2.4e-02
4	GTEx	Brain Cerebellum	0.1560	0.0690	9.1e-04	0.050	NA	0.018	NA	0.036	1.4e-02	NA	9.3e-02	NA	3.1e-02
5	GTEx	Cells Transformed fibroblasts	0.0520	0.0230	8.7e-04	0.049	NA	0.056	NA	0.058	1.4e-04	NA	4.6e-05	NA	3.8e-05
6	GTEx	Lung	0.0777	0.0317	1.1e-03	0.007	NA	-0.003	NA	0.000	9.3e-02	NA	6.0e-01	NA	3.4e-01
7	GTEx	Nerve Tibial	0.1651	0.0470	2.6e-13	0.277	NA	0.244	NA	0.253	8.9e-20	NA	2.5e-17	NA	5.8e-18
8	GTEx	Thyroid	0.0500	0.0260	7.4e-03	0.045	NA	0.028	NA	0.039	2.2e-04	NA	3.1e-03	NA	5.2e-04
9	TCGA	Colon Adenocarcinoma	0.0780	0.0600	9.0e-03	-0.005	-0.004	-0.005	NA	-0.003	9.1e-01	0.67000	8.9e-01	NA	5.7e-01
10	TCGA	Kidney Renal Clear Cell Carcinoma	0.0289	0.0239	1.1e-03	0.034	0.025	0.026	NA	0.030	9.8e-05	0.00069	5.2e-04	NA	2.3e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Crohns Disease (2012)	14.9	24.0	31.1	-4.8	-5.2	-4.7	-5.0	-5.6	-4.9	-5.5	-5.4	0.0	-5.4
Crohns Disease (2017)	12.7	28.0	33.2	-5.2	-5.5	-4.1	-5.4	-5.5	-5.3	-5.3	-5.3	-5.8	-5.3
Breast Cancer	11.3	27.2	34.6	4.9	4.7	3.6	5.9	5.5	4.3	5.6	5.5	5.9	5.8
Irritable Bowel Disease (IBD)	11.2	26.8	30.6	-4.8	-5.2	-4.2	-5.4	-5.5	-5.1	-5.5	-5.4	-5.2	-5.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	10.6	12.6	17.0	-2.9	-3.3	-3.3	-3.1	-4.0	-3.0	-4.1	-4.0	-3.5	-4.1
Medication: Ramipril	9.4	12.1	14.9	-3.6	-3.6	-2.9	-3.6	-3.7	-3.9	-3.7	-3.6	-2.2	-3.6
Number of full brothers	6.0	7.5	10.4	-2.8	-2.5	-2.9	-2.6	-3.0	-2.7	-3.0	-3.2	-1.6	-2.9
Pain experienced in last month	5.9	9.8	13.5	-3.2	-3.1	-2.9	-3.7	-3.4	-2.8	-3.4	-3.5	-2.3	-2.9
Tinnitus: Yes, but not now, but have in the past	5.0	5.3	7.6	2.0	2.3	2.8	1.9	2.3	2.3	2.1	2.1	2.6	2.6
Medication: Ibuprofen (e.g. Nurofen)	5.0	6.3	9.5	3.0	3.0	3.1	2.3	2.1	2.8	2.0	2.0	2.5	2.1
Medication: Atorvastatin	5.0	6.2	9.1	-2.0	-2.1	-2.0	-2.4	-2.8	-2.3	-3.0	-2.6	-2.6	-2.7
Medication for cholesterol, blood pressure or diabetes	4.7	7.8	10.1	2.5	2.6	2.6	3.0	3.1	2.7	3.2	3.1	1.9	2.9
Ulcerative Colitis (UC)	4.5	8.5	11.5	-2.4	-2.6	-2.4	-2.9	-3.2	-2.5	-3.4	-3.4	-3.0	-3.0
Nervous feelings	4.5	8.4	12.0	2.2	2.6	3.3	2.5	3.3	2.8	3.4	3.5	2.1	3.0
Medication: Ibuprofen	4.5	5.3	8.8	2.8	2.9	3.0	1.8	1.9	2.6	1.8	1.9	2.0	1.8
Breast cancer (self-reported)	4.4	5.3	10.6	-2.4	-2.4	-2.1	-1.6	-2.2	-2.3	-2.1	-2.2	-3.2	-2.1
Hair/balding pattern: Pattern 2	4.3	5.5	7.2	-2.3	-2.1	-2.3	-2.4	-2.6	-2.4	-2.7	-2.5	-1.2	-2.4
High blood pressure (mother)	4.0	5.6	8.6	2.3	2.0	2.9	2.7	2.3	2.5	2.2	2.2	1.9	2.2
Medication: Blood pressure	3.9	6.9	9.0	-2.5	-2.4	-2.2	-3.0	-2.8	-2.6	-2.9	-2.8	-1.9	-2.9
Mean Putamen Volume	3.7	4.3	5.8	-2.4	-2.4	-2.2	-1.8	-2.1	-2.3	-2.1	-1.4	-1.3	-2.3
Current tobacco smoking	3.7	6.0	7.9	-2.8	-2.8	-2.5	-2.7	-2.4	-2.8	-2.3	-2.2	0.6	-2.6
Worrier / anxious feelings	3.7	7.1	10.0	2.3	2.6	3.2	1.9	2.9	3.1	3.0	3.0	1.4	2.6
Qualifications: NVQ or HND or HNC or equivalent	3.7	4.4	7.1	-1.5	-1.9	-2.5	-1.8	-2.4	-1.5	-2.7	-2.7	-1.4	-2.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.7	4.4	6.2	2.1	1.9	2.1	2.3	2.2	1.8	2.5	2.4	1.1	2.2
Breastfed as a baby	3.5	4.3	7.0	-1.9	-2.0	-2.6	-1.5	-1.9	-2.3	-1.9	-1.9	-2.4	-2.1
Birth weight	3.4	7.5	12.5	2.8	2.5	0.8	2.0	3.3	2.2	3.1	3.5	3.2	2.8
Bipolar Disorder (2018)	3.3	5.2	8.6	-2.7	-2.4	-1.0	-2.8	-2.5	-2.3	-2.2	-2.2	0.0	-2.9
Number of full sisters	3.2	4.0	8.9	-1.7	-2.0	-3.0	-1.2	-2.2	-1.7	-2.4	-1.9	-0.7	-2.2
Frequency of depressed mood in last 2 weeks	3.1	4.3	6.4	-2.2	-1.9	-0.6	-2.1	-2.2	-1.8	-2.2	-2.5	-2.4	-2.2
Qualifications: CSEs or equivalent	3.1	4.1	6.4	-2.0	-1.9	-2.2	-1.9	-2.3	-1.7	-2.5	-2.3	-0.5	-2.3
Mouth/teeth dental problems: Dentures	3.0	5.1	8.5	-1.4	-1.8	-2.0	-2.7	-2.5	-1.2	-2.9	-2.6	-2.2	-2.5
Financial situation satisfaction	3.0	3.8	5.7	-1.6	-1.4	-2.1	-2.4	-2.1	-1.6	-2.2	-2.2	-1.0	-2.2
Alcohol drinker status: Previous	3.0	3.4	4.9	-2.1	-2.2	-1.9	-1.3	-1.7	-2.2	-1.6	-1.4	-1.6	-2.0
Bipolar Disorder or Schizophrenia	2.8	6.8	10.9	-3.2	-2.8	-1.0	-3.1	-2.9	-2.3	-2.6	-2.7	0.0	-3.3
Hayfever, allergic rhinitis or eczema	2.8	6.0	12.7	-3.1	-2.8	-1.5	-3.6	-2.1	-2.7	-1.8	-1.4	-2.2	-2.4
Worry (Nagel 2018)	2.7	5.8	9.9	1.7	2.0	3.1	1.4	2.9	2.1	3.0	3.1	1.2	2.4
Time employed in main current job	2.7	3.1	5.2	1.8	1.7	0.9	1.7	1.8	2.3	1.7	1.7	2.1	1.7
Illnesses of father: None of the above (group 1)	2.7	3.3	6.1	-1.5	-1.4	-1.6	-1.3	-2.1	-1.5	-2.0	-2.3	-2.5	-1.6
Schizophrenia (2014)	2.6	5.7	9.1	-2.6	-2.5	-1.2	-2.7	-2.8	-1.9	-2.6	-2.8	0.0	-3.0
Asthma (self-reported)	2.6	5.1	7.1	-2.7	-2.5	-1.1	-2.6	-2.3	-2.4	-2.1	-2.1	-1.8	-2.5
Miserableness	2.6	4.4	7.1	-2.2	-1.7	-0.1	-2.7	-2.4	-1.4	-2.4	-2.5	-2.1	-2.3
Commuting to job workplace: Public transport	2.6	3.1	9.2	1.3	1.4	1.9	1.2	1.6	1.6	1.5	1.8	3.0	1.4
Allergy or Eczema	2.5	6.5	11.7	-3.2	-3.0	-1.6	-3.4	-2.2	-2.9	-1.9	-1.6	-2.5	-2.5
Allergy	2.5	5.7	12.9	3.0	2.7	1.4	3.6	2.0	2.7	1.7	1.4	2.0	2.4
Pain all over the body in last month	2.5	2.7	3.6	1.9	1.8	1.3	1.7	1.8	1.6	1.7	1.7	0.9	1.7
Qualifications: College or University degree	2.5	7.7	17.1	2.3	2.8	4.1	2.4	2.9	2.5	3.1	2.6	1.1	3.0
Migraine (self-reported)	2.5	3.1	7.3	1.6	1.5	2.7	1.5	1.7	2.1	1.7	1.8	1.4	1.4
Chest pain or discomfort	2.5	3.6	5.4	-2.0	-1.7	-1.4	-2.3	-1.9	-2.1	-2.0	-1.8	-1.4	-1.9
Depression (Nagel 2018)	2.3	3.5	5.9	-2.4	-1.9	-0.4	-2.3	-1.8	-1.8	-1.7	-1.7	-2.1	-1.8
Severe depression (siblings)	2.3	2.6	5.1	-1.4	-1.3	-1.2	-2.1	-2.0	-1.0	-2.0	-2.2	-0.8	-1.4
Smoking Status	2.2	5.4	8.5	-2.6	-2.6	-2.2	-2.9	-2.4	-2.4	-2.3	-2.2	-0.4	-2.3
Tanning	2.2	27.0	32.7	-5.4	-5.3	-4.1	-4.7	-5.5	-5.4	-5.6	-5.4	-4.6	-5.7
Asthma	2.2	4.2	5.5	-2.3	-2.2	-1.0	-2.3	-2.2	-2.1	-2.0	-2.0	-1.8	-2.3
Pulse wave reflection index	2.2	2.7	5.8	-1.7	-1.8	-1.5	-1.2	-1.4	-1.9	-1.5	-1.3	-2.4	-1.3
Loud music exposure frequency	2.2	2.4	3.8	1.1	1.3	1.9	1.6	1.6	1.8	1.7	1.4	1.3	1.4
Heart disease (mother)	2.2	2.7	4.1	2.0	1.5	0.9	1.4	1.7	1.9	1.5	1.6	1.9	1.8
Smoking status: Current	2.2	3.5	4.9	-2.1	-2.1	-1.8	-2.2	-1.7	-2.0	-1.6	-1.5	1.2	-2.0
High cholesterol (Self-reported)	2.2	4.0	7.0	-1.6	-1.9	-1.0	-1.9	-2.4	-1.5	-2.6	-2.2	-1.6	-2.6
Cardiovascular Disease	2.1	7.1	9.6	-2.4	-2.7	-2.0	-2.7	-3.0	-2.7	-3.1	-2.9	-1.6	-3.0
Hair/balding pattern: Pattern 3	2.1	3.1	6.9	2.0	1.9	2.6	1.4	1.6	2.2	1.6	1.3	0.1	1.6
Medication: Aspirin	2.1	2.7	5.3	-0.9	-1.1	-1.3	-1.7	-2.0	-1.1	-2.3	-2.2	-1.5	-1.6
Maternal smoking around birth	2.0	2.9	5.1	-1.5	-1.6	-1.9	-1.9	-1.8	-1.5	-1.9	-1.7	-0.1	-2.3
Impedance of leg (left)	2.0	9.6	26.2	-3.5	-2.9	0.5	-4.3	-2.8	-2.2	-2.6	-2.5	-5.1	-2.3
Risk taking	2.0	3.0	6.1	-1.7	-1.8	-1.3	-2.5	-1.9	-1.6	-1.8	-1.8	-0.2	-1.8
Basal cell carcinoma (self-reported)	2.0	2.3	4.9	1.2	1.3	0.9	0.8	1.9	0.7	1.9	2.1	2.2	1.3
Lung FVC	1.9	9.8	21.2	3.0	3.0	2.6	4.6	3.1	2.5	3.1	2.9	3.2	2.7
Comparative body size at age 10	1.9	5.1	9.6	2.2	1.9	1.7	2.1	2.1	2.4	2.2	2.0	3.1	2.6
Pulse wave peak to peak time	1.9	2.2	3.7	1.8	1.8	1.2	1.4	1.2	1.9	1.3	1.0	1.4	1.6
Shortness of breath walking on level ground	1.9	2.3	4.8	1.6	1.6	0.7	1.2	1.5	1.5	1.4	1.5	2.2	1.4
Guilty feelings	1.9	2.9	5.6	-2.4	-2.2	-1.2	-1.8	-1.6	-2.1	-1.3	-1.4	-0.4	-1.7
Ulcerative Colitis	1.8	2.5	4.3	-1.0	-1.4	-1.5	-2.1	-1.9	-1.4	-2.0	-1.8	0.0	-1.8
Impedance of leg (right)	1.8	8.8	28.4	-3.3	-2.8	0.6	-3.9	-2.6	-2.3	-2.3	-2.2	-5.3	-2.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.8	2.4	4.3	-1.6	-1.4	-0.4	-2.1	-1.7	-1.7	-1.6	-1.7	-0.8	-1.6
Pulse wave Arterial Stiffness index	1.8	2.1	3.6	-1.7	-1.8	-1.2	-1.4	-1.1	-1.9	-1.2	-0.9	-1.3	-1.5
Age at first live birth	1.8	3.2	5.2	1.7	1.8	2.1	0.8	1.8	1.6	1.7	1.8	2.3	1.9
Health satisfaction	1.8	2.3	5.0	1.6	1.6	1.4	2.2	1.6	1.1	1.6	1.4	0.6	1.6
Family relationship satisfaction	1.8	2.2	3.7	-1.3	-1.0	-0.4	-1.6	-1.8	-1.1	-1.9	-1.9	-1.6	-1.7
Respiratory disease	1.7	3.8	7.0	-2.6	-2.5	-1.1	-2.6	-1.8	-2.3	-1.5	-1.3	-0.8	-2.0
Had other major operations	1.7	2.0	3.4	-1.3	-1.4	-1.9	-0.7	-1.3	-1.7	-1.3	-1.4	-1.6	-1.5
Medication: Paracetamol	1.7	2.6	5.1	2.0	2.2	2.1	1.4	1.4	1.9	1.3	1.1	0.3	1.1
Wheeze or whistling in the chest in last year	1.6	2.8	4.8	-1.9	-1.8	-0.9	-2.0	-1.8	-1.7	-1.7	-1.5	-0.4	-2.2
Deep venous thrombosis (DVT) (self-reported)	1.6	2.1	3.4	-1.2	-1.1	-0.6	-1.2	-1.7	-0.9	-1.7	-1.8	-1.8	-1.8
Mouth/teeth dental problems	1.5	2.3	4.5	0.8	1.1	1.1	2.1	1.8	0.9	2.0	2.1	1.0	1.4
Medication: Cholesterol lowering	1.5	2.3	4.3	-1.0	-1.3	-1.4	-1.3	-1.9	-1.1	-2.1	-1.9	-1.0	-1.7
Blood clot in the leg (DVT)	1.5	1.9	3.1	-1.1	-1.1	-0.6	-1.3	-1.6	-0.8	-1.7	-1.8	-1.6	-1.7
Medication: Paracetamol	1.5	2.4	4.5	2.0	2.1	2.1	1.5	1.3	1.9	1.3	1.0	0.8	1.0
Medication: Aspirin	1.5	1.9	3.9	-0.7	-1.0	-1.2	-1.5	-1.7	-1.0	-2.0	-1.8	-1.1	-1.4
Eye problems/disorders: Cataract	1.5	1.7	2.3	-1.1	-1.1	-1.3	-1.2	-1.5	-1.1	-1.4	-1.4	-1.3	-1.4
Medication: Gliclazide	1.5	1.7	3.1	-1.0	-0.8	-1.0	-1.8	-1.6	-0.2	-1.7	-1.7	-0.9	-1.5
Depressed Affect (Nagel 2018)	1.4	3.0	5.3	-1.8	-1.6	-0.0	-2.3	-1.9	-1.5	-1.8	-1.9	-1.7	-1.9
Fasting Glucose	1.4	1.7	2.8	-0.9	-1.2	-1.7	-1.3	-1.3	-1.4	-1.2	-1.5	-1.1	-1.3
Relative age voice broke	1.4	2.1	3.2	-1.8	-1.8	-0.7	-1.1	-1.6	-1.3	-1.5	-1.4	-1.5	-1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	1.4	1.8	3.3	-1.8	-1.6	-0.6	-1.6	-1.1	-1.7	-0.9	-1.3	-0.6	-1.4
Hypertension (Self-reported)	1.4	3.8	6.1	-2.3	-2.3	-1.5	-2.0	-1.9	-2.5	-1.9	-1.7	-0.8	-2.1
Qualifications: A levels/AS levels or equivalent	1.3	2.8	7.0	1.6	1.8	2.6	1.4	1.6	1.4	1.8	1.5	-0.8	1.7
Myopia	1.3	1.9	3.2	-1.6	-1.8	-1.3	-1.3	-1.4	-1.7	-1.2	-1.3	-0.9	-1.2
Vascular/heart problems diagnosed by doctor	1.3	3.5	5.0	2.0	2.0	1.6	1.9	1.9	2.2	1.9	1.9	0.8	2.0
HDL Cholesterol	1.2	1.9	3.1	1.6	1.3	0.9	1.5	1.8	1.8	1.7	1.7	0.0	0.0
Type 2 Diabetes (T2D) (2012)	1.2	1.4	4.2	-0.4	-1.7	-0.9	-0.9	-1.0	-1.5	-1.3	-2.1	0.0	0.0
Hayfever/allergic rhinitis (self-reported)	1.2	1.6	2.5	-1.5	-1.5	-1.3	-1.6	-0.9	-1.6	-0.9	-0.9	-1.0	-0.9
Exposure to tobacco smoke at home	1.2	1.4	3.2	1.4	1.7	1.2	1.0	0.9	1.0	0.8	0.5	1.8	0.9
Number of self-reported non-cancer illnesses	1.2	2.0	4.3	-1.7	-1.7	-1.4	-2.1	-1.1	-1.6	-1.0	-0.8	-0.4	-1.7
Average weekly champagne plus white wine intake	1.2	1.7	2.3	1.3	1.2	1.4	1.2	1.2	1.4	1.5	1.1	1.2	1.4
Age started oral contraceptive pill	1.2	1.5	2.9	1.4	1.2	1.4	0.4	1.3	1.2	1.2	1.2	0.7	1.7
Diastolic blood pressure, automated reading	1.2	3.6	5.8	2.0	2.3	2.2	2.4	1.9	1.9	1.9	1.7	0.9	1.4
Schizophrenia (2018)	1.1	2.3	3.6	-1.9	-1.7	-0.5	-1.8	-1.7	-1.1	-1.6	-1.7	0.2	-1.9
Alzheimer’s Disease (in father)	1.1	1.2	1.9	0.8	0.7	1.4	1.3	1.0	1.0	1.0	1.3	0.9	1.2
Reaction Time	1.1	2.1	4.3	-1.8	-1.3	-0.5	-0.9	-1.6	-1.2	-1.6	-1.5	-2.1	-1.4
Body Mass Index (BMI) (2010)	1.1	1.6	3.5	1.6	1.6	0.6	1.9	1.4	1.3	1.3	1.2	0.0	0.0
Diabetes (self-reported)	1.1	1.7	4.5	-0.3	-0.2	-0.6	-1.2	-1.6	-0.1	-1.8	-2.1	-1.7	-1.2
Forced expiratory volume in 1-second (FEV1), Best measure	1.1	3.5	5.1	1.7	1.8	1.7	2.3	2.0	1.2	2.1	1.9	2.0	1.7
Number of children fathered	1.1	1.3	4.3	-0.9	-1.0	-2.1	-0.4	-0.9	-1.3	-1.1	-1.0	-0.4	-1.2
Mean time to correctly identify matches	1.1	2.2	5.9	-1.8	-1.5	-0.9	-1.0	-1.5	-1.0	-1.5	-1.2	-2.4	-1.2
Fractured/broken bones in last 5 years	1.1	1.5	3.4	-0.9	-0.5	-0.0	-0.8	-1.6	-0.9	-1.8	-1.8	-1.0	-1.4
Coronary Artery Disease (CAD)	1.0	1.2	3.6	1.0	1.8	1.9	1.3	0.8	1.0	0.7	0.7	0.0	0.0
Hair Pigment	1.0	27.3	35.5	-5.3	-4.8	-3.7	-5.1	-5.4	-5.2	-5.6	-5.5	-6.0	-5.3
Townsend deprivation index at recruitment	1.0	1.4	3.2	-0.7	-0.8	-0.9	-1.1	-1.5	-0.8	-1.8	-1.8	0.1	-1.2
Impedance of arm (right)	1.0	4.8	12.0	1.1	0.9	3.5	-0.3	2.2	1.9	2.7	2.7	-1.9	2.7
Arm fat percentage (right)	1.0	4.1	6.7	1.9	1.4	0.8	2.3	2.3	1.5	2.6	2.6	1.9	2.2
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.7	2.6	-1.6	-1.4	-0.7	-1.4	-1.3	-1.5	-1.2	-1.6	-0.6	-1.3
Pulse rate, automated reading	1.0	3.1	5.9	1.2	1.5	2.3	1.7	2.0	1.6	2.2	2.4	0.5	1.3
Leg pain on walking	1.0	1.2	2.4	0.9	1.1	0.7	1.5	1.1	1.0	1.1	1.2	1.2	0.9
LDL Cholesterol	0.9	1.5	2.9	-1.7	-1.6	-0.9	-1.6	-1.3	-1.3	-1.2	-0.9	0.0	0.0
Diabetes (mother)	0.9	1.1	2.1	-0.8	-1.0	-1.1	-0.9	-1.2	-0.6	-1.4	-1.3	-1.2	-0.9
Leg predicted mass (left)	0.9	4.8	14.1	2.2	1.9	-0.8	3.0	2.2	0.9	1.9	1.9	3.8	1.8
Forced expiratory volume in 1-second (FEV1)	0.9	2.9	5.7	1.5	1.6	1.6	2.4	1.9	0.9	1.9	1.7	1.7	1.5
Impedance of arm (left)	0.9	4.2	8.7	0.6	0.5	3.0	-0.6	2.1	1.5	2.7	2.7	-2.3	2.4
Eye problems/disorders: None of the above	0.9	1.1	2.9	1.1	1.1	0.3	1.0	1.0	0.9	0.9	1.0	1.7	0.8
Leg fat-free mass (right)	0.9	4.8	15.3	2.2	1.9	-1.0	2.9	2.1	1.0	1.8	1.7	3.9	1.7
Loneliness, isolation	0.9	1.3	2.6	-1.1	-0.8	-0.2	-1.6	-1.3	-1.2	-1.2	-1.4	-0.4	-1.3
Long-standing illness, disability or infirmity	0.9	1.4	2.2	-1.1	-1.4	-1.4	-1.3	-1.0	-1.3	-0.9	-0.9	-1.5	-1.0
Diabetes diagnosed by doctor	0.9	1.5	4.4	-0.2	-0.1	-0.5	-1.2	-1.6	-0.1	-1.8	-2.1	-1.4	-1.3
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	1.5	-1.1	-0.8	0.3	-1.2	-1.2	-0.7	-0.9	-1.2	-1.1	-0.9
Leg predicted mass (right)	0.9	5.0	15.4	2.2	2.0	-0.9	3.0	2.1	1.1	1.9	1.8	3.9	1.7
Illnesses of father: High blood pressure	0.9	1.2	4.6	0.7	1.1	2.1	0.6	0.8	0.9	0.8	0.6	1.5	0.7
Ever had prostate specific antigen (PSA) test	0.9	1.0	2.1	0.5	0.2	1.1	0.5	1.1	1.1	1.3	1.4	1.2	0.9
Primary Biliary Cirrhosis	0.8	1.1	1.9	-1.2	-1.1	-1.2	-1.4	-1.1	-0.4	-1.1	-1.2	-0.1	-1.1
Relative age of first facial hair	0.8	1.6	3.8	-1.6	-1.9	-1.2	-1.5	-1.1	-1.1	-1.2	-0.5	-0.1	-1.1
Eye problems/disorders: Diabetes related eye disease	0.8	0.8	1.6	0.8	1.1	1.3	0.7	0.8	1.3	0.9	0.7	0.2	0.9
Supplements: Zinc	0.8	0.9	1.6	0.8	0.9	1.0	0.8	1.0	0.8	1.1	1.3	1.1	0.5
Leg fat-free mass (left)	0.8	4.5	13.4	2.1	1.8	-0.9	2.9	2.1	0.8	1.9	1.8	3.7	1.7
High blood pressure	0.8	2.3	3.9	-1.9	-1.8	-1.1	-1.6	-1.5	-2.0	-1.4	-1.2	-0.4	-1.6
Stomach or abdominal pain in last month	0.8	0.9	2.1	0.6	0.6	1.4	1.0	1.2	0.8	1.2	1.3	0.0	0.8
Forced vital capacity (FVC)	0.8	3.1	6.2	1.5	1.6	1.4	2.5	1.9	0.8	1.9	1.7	2.2	1.5
Heart attack	0.8	1.0	2.6	-0.4	-0.4	-0.9	-0.3	-1.3	-0.7	-1.5	-1.6	-0.9	-0.9
Illnesses of mother	0.8	1.0	1.8	-0.8	-0.6	-0.8	-1.2	-1.1	-1.0	-1.1	-1.4	-0.8	-1.1
Hair/balding pattern: Pattern 4	0.8	2.0	4.9	1.4	1.2	0.3	2.2	1.5	1.0	1.7	1.6	0.4	1.7
Forced vital capacity (FVC), Best measure	0.8	3.1	5.3	1.4	1.6	1.3	2.1	2.0	0.8	2.0	1.9	2.3	1.6
Supplements: Vitamin C	0.8	1.0	2.9	1.2	1.4	1.7	0.6	0.9	1.0	0.5	0.8	0.5	0.6
Arm fat percentage (left)	0.8	3.4	6.5	1.6	1.1	0.4	2.0	2.2	1.2	2.5	2.5	1.7	2.0
Ever taken oral contraceptive pill	0.8	0.8	1.5	-0.9	-0.8	0.1	-1.2	-1.2	-0.4	-1.0	-1.2	-0.4	-1.2
Verbal and Numeric Reasoning (VNR)	0.7	1.6	3.0	1.3	1.3	1.7	1.2	1.1	1.0	1.0	0.8	1.3	1.5
Sensitivity / hurt feelings	0.7	1.3	5.6	0.1	0.3	2.4	-0.0	1.0	1.1	1.3	1.4	-0.2	1.1
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	1.5	-1.1	-1.2	-0.8	-1.2	-0.9	-1.1	-0.6	-0.7	-0.9	-1.0
Ever used hormone-replacement therapy (HRT)	0.7	0.9	1.9	0.9	1.1	0.3	0.8	1.2	1.0	1.2	1.4	0.6	0.8
Fed-up feelings	0.7	1.4	2.3	-1.1	-0.9	0.2	-1.5	-1.4	-0.5	-1.4	-1.5	-0.9	-1.4
Age when periods started (menarche)	0.7	1.6	2.6	-1.2	-1.6	-1.3	-1.2	-1.3	-1.2	-1.3	-1.4	-1.5	-0.8
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	1.6	0.7	0.8	0.6	1.0	1.0	0.9	1.2	1.3	0.7	0.4
Past tobacco smoking	0.7	1.3	2.0	1.1	1.4	0.7	1.4	1.2	0.9	1.4	1.1	0.6	1.3
Father’s age at death	0.7	1.0	1.7	0.9	0.8	1.0	0.5	1.1	1.3	1.0	1.3	0.8	1.1
Arm fat mass (right)	0.7	2.8	5.6	1.6	1.1	-0.3	2.2	1.8	0.9	1.9	1.9	2.4	1.6
Birth weight of first child	0.7	1.2	3.4	0.9	0.2	-0.4	0.2	1.3	0.5	1.4	1.4	1.9	1.4
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	2.4	0.6	0.9	1.6	1.0	0.8	1.1	1.1	0.7	-1.2	1.2
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	2.8	-0.4	-0.5	-0.7	-1.0	-1.1	-0.5	-1.3	-1.7	-0.6	-0.8
Medication: Allopurinol	0.7	0.9	2.8	0.0	0.0	-1.7	1.2	0.8	-0.7	0.8	1.1	1.4	0.5
Age at last live birth	0.7	1.0	2.7	1.0	1.1	1.6	0.1	0.8	1.1	0.8	0.7	1.0	1.0
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	2.4	0.0	0.2	0.5	0.4	1.2	-0.3	1.2	1.6	1.2	1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.9	2.4	-0.6	-0.6	-1.5	-0.9	-0.8	-1.0	-0.9	-0.9	-0.2	-1.2
Smoking status: Previous	0.7	1.0	1.5	-0.8	-1.2	-0.7	-1.1	-1.1	-0.8	-1.2	-1.0	-1.1	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.6	2.9	0.8	0.8	1.2	1.5	1.5	0.2	1.7	1.7	1.2	1.1
Alcohol drinker status: Never	0.7	0.8	1.5	0.8	0.8	0.9	1.2	0.9	0.7	1.0	0.7	-1.0	0.8
Ever depressed for a whole week	0.7	0.8	1.6	-1.3	-1.1	-0.0	-1.1	-1.0	-0.6	-0.9	-1.0	-0.2	-1.0
Blood Eosinophil Count	0.6	4.4	11.8	2.1	2.4	3.4	1.6	1.6	2.8	1.8	1.4	0.6	2.1
Blood White Count	0.6	4.5	7.5	-2.1	-2.0	-1.7	-2.7	-2.2	-1.9	-2.2	-2.1	-0.8	-2.6
Type 2 Diabetes (T2D) (2018)	0.6	1.2	3.3	-0.2	0.1	-0.1	-1.1	-1.4	0.2	-1.6	-1.8	-0.9	-1.3
Ever had hysterectomy (womb removed)	0.6	0.7	1.3	0.7	0.9	0.4	0.6	1.0	0.4	1.1	1.1	0.8	0.6
Serious illness, injury or assault to yourself	0.6	0.7	2.7	-0.2	-0.2	0.1	-0.9	-0.9	-0.1	-0.9	-1.1	-1.6	-0.7
Chronic bronchitis/emphysema (father)	0.6	0.6	3.1	0.3	0.3	0.2	0.8	0.7	0.5	0.7	0.7	1.8	0.9
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.3	-0.8	-0.9	-0.6	-0.8	-0.9	-0.9	-1.1	-0.7	0.2	-1.1
Neck or shoulder pain in last month	0.6	0.9	2.3	1.1	1.4	1.1	1.5	0.7	0.8	0.6	0.7	0.3	0.6
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.2	-0.4	-0.5	-1.0	-1.0	-0.6	-0.4	-0.8	-0.9	-1.0	-1.1
Knee pain experienced in last month	0.6	1.0	2.1	0.9	0.8	-0.0	1.4	1.1	0.3	1.3	1.2	1.5	0.5
Back pain experienced in last month	0.6	0.9	2.3	0.6	0.6	0.7	1.5	1.0	0.4	1.0	1.1	0.8	1.0
Arm fat mass (left)	0.6	2.4	5.2	1.3	0.8	-0.7	2.0	1.7	0.7	1.8	1.8	2.3	1.4
Ever smoked	0.6	1.1	1.8	-0.9	-1.2	-1.1	-1.0	-1.2	-0.8	-1.3	-1.1	0.1	-1.1
Average weekly beer plus cider intake	0.6	0.9	2.1	1.4	1.1	0.6	0.6	0.4	1.4	0.3	0.4	1.4	0.6
Commuting to job workplace: Cycle	0.6	0.8	6.6	-0.1	0.2	0.8	0.4	0.0	-0.1	0.0	-0.1	-2.6	0.4
Heart attack/myocardial infarction (self-reported)	0.6	0.8	2.3	-0.2	-0.3	-0.8	-0.2	-1.2	-0.6	-1.4	-1.5	-0.8	-0.8
Impedance of whole body	0.6	2.9	15.6	-1.3	-1.0	2.1	-2.5	-0.1	-0.2	0.3	0.3	-4.0	0.3
Alzheimer’s Disease (in mother)	0.5	0.6	1.5	-1.0	-0.6	-0.5	-1.2	-0.6	-1.0	-0.4	-0.5	0.8	-0.5
HbA1C	0.5	0.6	1.4	-0.6	-0.0	0.2	-0.5	-0.9	0.5	-0.9	-1.2	-0.9	-1.2
Waist Hip Ratio (WHR)	0.5	2.2	7.6	-1.0	-1.5	0.1	-2.8	-1.3	-0.3	-1.4	-1.2	-2.2	-1.2
Hand grip strength (left)	0.5	1.4	4.4	-0.6	-0.7	-2.1	-0.8	-1.0	-1.6	-1.3	-1.1	0.7	-1.0
Vitamin and mineral supplements	0.5	0.7	2.9	-0.3	-0.2	-0.2	-0.4	-0.9	-0.1	-0.9	-1.3	-1.7	-0.2
Diabetes (father)	0.5	0.6	1.7	-0.6	-0.6	-1.3	-0.8	-0.7	-0.8	-0.7	-0.5	0.2	-0.8
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	2.8	-1.4	-0.8	-0.1	-1.7	-0.7	-1.0	-0.6	-0.7	-0.1	-0.6
Financial difficulties in last 2 years	0.5	0.7	1.8	1.0	0.9	1.2	0.7	0.2	1.3	0.1	-0.0	1.1	0.3
Depression (self-reported)	0.5	0.5	2.6	-0.9	-0.5	-0.7	-1.6	-0.4	-0.6	-0.2	-0.3	0.4	-0.6
Tense / ‘highly strung’	0.5	0.9	2.7	-1.3	-0.8	0.4	-1.1	-0.6	-1.2	-0.4	-0.3	-1.7	-0.4
Peak expiratory flow (PEF)	0.5	1.2	1.8	1.0	0.9	1.0	1.1	1.2	0.8	1.4	1.3	1.3	0.9
Gout (self-reported)	0.5	0.7	2.0	0.1	0.0	-1.3	1.4	0.8	-0.6	0.8	0.8	0.1	0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.4	-1.0	-1.1	-1.2	-0.8	-0.4	-0.8	-0.4	-0.3	-0.0	-1.0
Emphysema/chronic bronchitis	0.5	0.6	1.7	-0.8	-0.7	0.2	-1.3	-0.6	-0.6	-0.6	-0.4	1.1	-0.5
Medication for pain relief, constipation, heartburn	0.5	0.8	2.1	-1.5	-1.4	-1.3	-0.7	-0.4	-1.3	-0.2	-0.3	-0.3	-0.2
Medication: Seretide 50 evohaler	0.5	0.5	1.3	-0.3	-0.4	-1.2	-0.7	-0.8	-0.5	-1.0	-0.8	0.2	-0.9
Suffer from ‘nerves’	0.5	0.9	2.1	0.7	1.1	1.4	0.4	1.0	0.8	1.1	1.1	0.6	0.6
Commuting to job workplace: Walk	0.5	0.6	1.1	1.1	0.7	-0.1	0.7	0.5	1.1	0.3	0.6	1.0	0.8
Osteoarthritis (self-reported)	0.5	0.6	1.5	0.9	0.7	-0.2	0.5	0.9	0.9	0.9	1.2	0.9	0.3
Number of operations (self-reported)	0.5	0.7	1.9	-0.5	-0.5	-1.0	-1.1	-0.8	-0.8	-0.8	-0.7	-0.5	-1.4
Supplements: Calcium	0.5	0.6	1.2	-0.6	-0.7	-0.7	-1.1	-0.6	-0.3	-0.9	-0.6	-0.8	-1.0
Ovarian Cancer	0.4	0.5	1.4	-1.1	-1.0	0.0	-0.2	-0.0	-0.9	0.2	0.4	1.2	-0.1
Rheumatoid Arthritis	0.4	0.6	1.0	0.9	0.7	0.5	0.6	0.8	1.0	0.8	0.8	0.7	0.9
Average weekly fortified wine intake	0.4	0.4	1.9	-0.3	-0.3	-0.5	0.6	-0.6	0.1	-0.6	-0.8	-1.4	-0.4
Body mass index (BMI)	0.4	1.6	5.5	1.1	0.8	-1.0	2.1	1.0	0.2	1.0	1.0	2.4	0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.8	2.9	-0.8	-1.2	-1.7	-0.1	-0.4	-1.7	-0.1	-0.3	-0.2	-0.4
Illnesses of siblings	0.4	0.5	1.1	0.2	0.8	1.0	0.5	0.8	0.3	0.9	0.9	0.0	1.0
Number of live births	0.4	0.5	1.4	-0.6	-0.5	-0.0	-1.2	-0.8	-0.4	-0.9	-0.9	-0.1	-0.8
Hypothyroidism/myxoedema (self-reported)	0.4	0.9	1.4	1.1	0.9	-0.2	1.1	1.1	0.7	1.1	1.2	0.7	0.8
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.3	-1.2	-0.9	-0.1	-1.1	-0.4	-0.8	-0.2	-0.2	0.3	-0.5
Alcohol intake frequency.	0.4	0.9	1.9	1.0	0.8	1.4	1.4	0.9	1.0	0.9	0.9	-0.0	0.6
Whole body fat-free mass	0.4	2.4	10.9	1.4	1.1	-1.7	2.3	1.0	0.2	0.7	0.7	3.3	0.6
Whole body water mass	0.4	2.3	10.2	1.3	1.1	-1.8	2.2	1.0	0.2	0.6	0.6	3.2	0.6
Hearing aid user	0.4	0.4	1.0	0.5	0.4	0.3	1.0	0.9	0.2	0.7	0.9	0.2	0.7
Basal metabolic rate	0.4	2.3	9.1	1.3	1.1	-1.6	2.3	1.1	0.2	0.8	0.8	3.0	0.7
Cholesterol lowering medication	0.4	0.6	1.8	-0.2	-0.5	-0.1	-0.6	-0.9	-0.5	-1.0	-0.9	-0.9	-1.3
Neuroticism (Nagel 2018)	0.3	0.6	3.4	-0.7	-0.3	1.8	-1.0	0.2	-0.1	0.4	0.4	-0.7	-0.4
Prostate Cancer	0.3	0.4	2.6	-0.5	-0.1	1.6	-0.0	-0.5	0.4	-0.3	-0.3	-0.9	-0.4
Neuroticism (2016)	0.3	0.4	2.2	-0.7	-0.3	1.5	-0.3	0.3	-0.2	0.4	0.3	-0.7	0.5
Triglycerides	0.3	0.5	0.9	-0.9	-0.1	-0.3	-0.9	-0.9	-1.0	-0.8	-0.9	0.0	0.0
Blood Platelet Count	0.3	3.8	12.5	-2.1	-1.8	0.6	-3.5	-1.8	-1.4	-2.0	-1.8	-0.6	-2.2
Neuroticism	0.3	0.6	3.6	-0.3	0.0	1.9	-0.7	0.5	0.4	0.6	0.7	-0.7	0.2
Number of treatments/medications taken	0.3	0.6	1.5	-0.6	-0.7	-0.6	-1.0	-0.7	-0.9	-0.7	-0.5	-0.6	-1.2
Average weekly spirits intake	0.3	0.4	0.9	-0.3	-0.2	-1.0	0.5	-0.7	-0.5	-0.7	-0.9	-0.3	-0.7
Medication for hormone replacement therapy	0.3	0.3	1.1	0.2	0.3	-0.5	0.9	0.4	-0.1	0.4	0.5	-1.1	0.0
Medication: Metformin	0.3	0.4	1.4	0.4	0.5	0.2	-0.6	-0.7	0.5	-0.9	-1.2	-0.3	-0.3
Trunk fat percentage	0.3	1.2	3.5	0.5	0.2	-0.1	0.9	1.5	0.2	1.8	1.9	0.4	1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	2.6	-0.7	-0.7	-1.6	0.9	0.1	-1.1	0.5	0.2	-1.0	0.1
Supplements: Glucosamine	0.3	0.3	1.2	0.5	0.4	0.1	0.4	0.8	0.4	0.6	1.1	0.7	0.2
Trunk fat mass	0.3	1.2	2.6	0.6	0.2	-0.8	1.2	1.4	-0.0	1.6	1.6	1.2	1.1
Neuroticism score	0.3	0.5	3.4	-0.3	0.2	1.9	-0.8	0.4	0.4	0.5	0.6	-0.3	0.2
Weight	0.3	1.5	4.8	0.8	0.5	-1.6	1.8	1.0	-0.3	0.9	0.9	2.2	0.6
Trunk fat-free mass	0.3	1.7	7.8	1.0	0.8	-2.0	1.9	0.5	-0.1	0.1	0.1	2.8	0.1
Falls in the last year	0.3	0.4	1.0	-1.0	-0.8	-0.5	-0.9	-0.6	-0.8	-0.4	-0.2	0.0	-0.6
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	0.9	-0.4	-0.6	-0.5	-0.9	-0.7	-0.1	-0.6	-0.9	0.2	-0.7
Medication: Lansoprazole	0.3	0.3	1.5	-0.7	-0.3	-0.8	-0.5	-0.2	-1.2	-0.2	-0.0	0.3	-0.5
Prospective memory result	0.3	0.4	1.3	-0.3	-0.3	-0.5	-0.3	0.6	-0.1	0.9	1.1	1.1	0.2
Lung cancer (father)	0.3	0.3	0.8	-0.5	-0.5	-0.7	-0.4	-0.5	-0.7	-0.4	-0.5	-0.9	-0.7
Trunk predicted mass	0.3	1.7	7.7	1.0	0.8	-2.0	1.9	0.4	-0.2	0.1	0.1	2.8	0.1
Headache pain in last month	0.3	0.4	2.1	0.5	0.4	1.4	0.4	0.6	0.5	0.8	0.8	0.2	-0.1
High blood pressure (siblings)	0.3	0.4	1.2	0.1	-0.0	0.7	0.5	0.6	0.4	0.7	0.9	1.1	0.1
Arm fat-free mass (right)	0.3	1.5	6.8	-0.2	-0.2	-2.6	0.9	-0.5	-1.2	-0.9	-0.9	1.9	-0.9
Arm predicted mass (right)	0.3	1.7	8.0	-0.2	-0.2	-2.8	0.9	-0.5	-1.2	-0.9	-0.9	2.0	-0.9
Overall health rating	0.3	0.7	1.6	0.9	0.7	0.9	0.9	0.6	1.1	0.5	0.6	1.3	0.4
Had major operations	0.3	0.3	0.8	0.1	-0.2	-0.4	-0.6	-0.5	-0.4	-0.5	-0.7	-0.8	-0.9
Average weekly red wine intake	0.3	0.5	1.3	-0.5	-0.8	-0.7	-1.1	-0.6	-0.5	-0.5	-0.5	-0.8	-0.4
Pain type(s) experienced in last month: Hip pain	0.3	0.4	2.7	0.0	-0.3	-1.6	0.0	0.0	-0.9	-0.1	0.0	-0.0	0.0
Arm fat-free mass (left)	0.3	1.5	6.4	0.5	0.4	-2.2	1.6	-0.0	-0.5	-0.4	-0.4	2.5	-0.3
Irritability	0.3	0.5	1.8	-0.6	0.0	1.0	-1.0	-0.4	-0.1	-0.4	-0.2	-1.3	-0.8
Unable to work because of sickness or disability	0.3	0.4	0.8	-0.9	-0.6	-0.5	-0.9	-0.4	-0.5	-0.4	-0.3	0.8	-0.7
Arm predicted mass (left)	0.3	1.5	6.2	0.4	0.3	-2.3	1.3	-0.2	-0.6	-0.6	-0.5	2.5	-0.5
Intelligence (Savage-Jansen 2018)	0.2	0.7	1.7	0.7	0.7	1.3	0.9	1.0	0.4	0.9	0.7	0.0	0.8
Major Depression (MDD)	0.2	0.2	0.5	-0.2	-0.7	0.4	-0.5	-0.5	-0.7	-0.5	-0.4	-0.2	-0.4
Lupus	0.2	0.3	0.8	-0.1	0.0	-0.3	0.3	0.6	-0.4	0.7	0.9	0.7	0.5
Blood Red Count	0.2	1.5	3.1	0.5	0.5	0.2	-1.8	-1.3	-0.0	-1.8	-1.8	-1.5	-1.2
Heel T-Score	0.2	1.6	4.9	-1.4	-1.4	-2.0	0.8	-0.4	-2.2	0.0	0.4	-1.2	-0.9
BMI	0.2	1.2	4.2	1.3	0.8	-1.5	2.0	0.6	0.4	0.5	0.5	1.4	0.4
Lung FEV1/FVC ratio	0.2	0.9	2.1	1.2	0.9	1.4	0.6	0.7	1.2	0.9	0.6	-0.5	0.6
Medication: Co-codamol	0.2	0.2	0.8	0.5	0.6	0.6	0.9	0.1	0.6	0.0	-0.1	-0.4	0.2
Hand grip strength (right)	0.2	0.5	1.9	-0.2	-0.3	-1.4	-0.3	-0.2	-1.1	-0.3	-0.0	1.1	-0.3
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.5	-0.0	0.1	-0.7	-0.1	0.0	-0.7	0.0	-0.0	0.7	-0.4
Multivitamins +/- minerals	0.2	0.3	0.8	0.4	0.3	-0.1	0.7	0.5	0.0	0.6	0.9	0.9	0.1
Medication: Atenolol	0.2	0.3	0.7	-0.6	-0.6	-0.8	-0.0	-0.4	-0.9	-0.5	-0.4	-0.3	-0.4
Medication: Levothyroxine sodium	0.2	0.3	0.8	0.7	0.3	-0.3	0.2	0.6	0.4	0.6	0.6	0.9	0.4
Number of incorrect matches in round	0.2	0.3	0.9	-0.6	-0.9	-0.7	-0.7	-0.2	-0.3	-0.1	-0.3	0.1	-0.6
Hearing difficulty/problems with background noise	0.2	0.4	1.6	0.2	0.3	1.3	0.0	0.6	0.2	0.6	0.4	1.0	0.4
Had menopause	0.2	0.3	0.7	0.5	0.5	0.1	0.7	0.6	0.5	0.5	0.9	-0.3	0.6
Medication: Simvastatin	0.2	0.3	0.8	-0.1	-0.5	-0.3	-0.1	-0.8	-0.2	-0.9	-0.9	-0.2	-0.6
Fluid intelligence score	0.2	0.3	1.2	0.6	0.7	1.1	0.1	0.3	0.3	0.3	-0.1	0.7	0.5
Hip circumference	0.2	0.7	2.0	0.3	0.2	-1.4	1.4	0.5	-0.5	0.6	0.5	1.2	0.2
Alcohol intake versus 10 years previously	0.2	0.3	1.0	-0.3	-0.1	-0.4	-0.2	-0.6	-0.5	-0.5	-0.5	-1.0	-0.4
Happiness	0.2	0.2	1.8	-0.3	-0.1	1.4	-0.3	-0.0	-0.0	0.1	-0.2	-0.2	-0.0
Ever highly irritable/argumentative for 2 days	0.2	0.3	1.2	-0.7	-0.6	-0.2	-0.4	-0.2	-0.4	-0.1	0.1	1.1	-0.6
Body fat percentage	0.2	0.7	2.1	0.3	0.0	-0.2	0.8	1.1	-0.1	1.4	1.4	0.3	0.9
Leg fat percentage (right)	0.2	0.8	2.3	-1.0	-1.1	-1.5	-0.2	-0.7	-1.5	-0.5	-0.4	-0.5	-0.8
Worry too long after embarrassment	0.2	0.4	1.7	-0.5	-0.1	1.3	-0.4	-0.1	0.0	-0.0	0.0	-1.1	-0.4
Whole body fat mass	0.2	0.9	1.7	0.6	0.2	-1.0	1.2	1.1	-0.1	1.3	1.3	1.2	0.8
Illnesses of father: Heart disease	0.2	0.2	0.5	-0.0	-0.4	-0.7	0.7	0.4	-0.3	0.4	0.7	-0.6	-0.2
Mood swings	0.2	0.3	1.5	-0.4	-0.1	1.2	-0.8	-0.4	-0.0	-0.5	-0.5	-0.5	-0.1
Ever had bowel cancer screening	0.2	0.3	0.8	-0.6	-0.9	-0.4	-0.3	0.2	-0.6	0.3	0.6	0.5	0.1
Friendships satisfaction	0.2	0.2	1.1	-0.5	-0.3	1.0	-0.2	-0.2	-0.3	-0.0	0.1	-0.6	-0.4
Medication for cholesterol	0.2	0.3	0.8	0.5	0.5	0.5	0.1	0.3	0.9	0.3	0.2	0.9	0.8
Mineral and other dietary supplements	0.2	0.2	0.5	0.4	0.3	0.3	0.0	0.4	0.5	0.6	0.1	0.7	0.7
Wears glasses or contact lenses	0.2	0.2	1.0	-0.2	-0.4	-0.4	-0.6	0.1	0.2	0.1	0.5	-1.0	-0.0
Mother’s age at death	0.2	0.3	1.8	0.3	0.1	0.2	0.4	0.2	0.4	0.4	0.3	-1.4	0.5
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.7	-0.4	-0.4	-0.0	-0.3	0.5	-0.7	0.7	0.9	0.3	0.0
Eye problems/disorders: Glaucoma	0.2	0.2	0.6	0.1	-0.3	0.3	0.3	0.7	0.0	0.6	0.8	-0.1	0.4
Medication: Blood pressure	0.2	0.4	1.6	-0.8	-0.9	-0.4	-0.3	-0.1	-1.3	-0.0	0.3	-0.3	-0.5
Medication: Bendroflumethiazide	0.2	0.4	1.0	-0.7	-0.4	-0.5	-1.0	-0.3	-1.0	-0.3	-0.0	0.2	-0.8
Leg fat percentage (left)	0.2	0.8	2.3	-1.0	-1.1	-1.5	-0.2	-0.6	-1.4	-0.5	-0.4	-0.2	-0.8
Heart disease (siblings)	0.2	0.3	0.7	0.7	0.1	-0.8	0.2	-0.5	0.6	-0.8	-0.6	-0.1	-0.4
Schizophrenia vs Biploar Disorder	0.1	0.1	0.6	0.7	0.3	0.2	0.5	0.1	0.5	-0.0	-0.1	0.0	0.3
Alzheimer’s Disease (including proxy)	0.1	0.2	1.2	-0.3	0.0	0.4	-0.1	0.1	-0.3	0.3	0.2	1.1	0.3
Age at First Birth	0.1	0.2	0.5	-0.5	-0.4	-0.7	-0.6	0.2	-0.2	0.5	0.4	0.0	0.5
Height	0.1	1.4	6.1	-1.3	-1.3	-2.5	-0.6	0.3	-2.0	0.4	0.3	-0.2	0.0
Systolic Blood Pressure	0.1	0.6	1.5	-0.9	-0.7	0.0	-0.8	-0.5	-1.2	-0.5	-0.3	-1.1	-1.1
Hypothyroidism (self reported)	0.1	0.2	0.5	0.1	-0.0	-0.7	0.5	0.5	-0.4	0.6	0.6	0.0	0.2
Hearing difficulty/problems: Yes	0.1	0.1	0.3	-0.3	-0.1	0.5	0.5	0.4	-0.1	0.6	0.4	0.1	0.1
Angina	0.1	0.1	0.2	0.4	0.2	-0.3	0.2	-0.3	-0.0	-0.4	-0.4	-0.1	-0.3
Pack years adult smoking proportion	0.1	0.1	0.2	0.1	0.2	-0.4	-0.3	0.3	-0.2	0.3	0.3	0.4	0.4
Taking other prescription medications	0.1	0.1	0.4	-0.1	-0.2	-0.5	-0.6	-0.1	-0.5	-0.0	-0.0	-0.2	-0.4
Waist circumference	0.1	0.5	3.4	-0.2	-0.7	-1.8	0.0	-0.2	-0.8	-0.2	-0.1	0.5	-0.5
Alcohol usually taken with meals	0.1	0.1	0.5	-0.2	-0.3	0.2	-0.3	0.2	0.1	0.3	0.3	-0.5	0.7
Ever unenthusiastic/disinterested for a whole week	0.1	0.2	1.3	-0.1	-0.0	0.4	-0.1	0.0	0.1	-0.0	0.1	1.2	-0.1
Qualifications: None of the above	0.1	0.2	0.7	0.6	0.2	-0.8	0.6	0.0	0.4	-0.2	-0.0	0.1	0.2
Pulse rate	0.1	0.1	0.5	-0.7	-0.0	-0.2	0.4	0.1	-0.4	0.3	0.3	-0.1	-0.4
Noisy workplace	0.1	0.2	0.6	-0.4	-0.4	-0.5	-0.3	-0.2	0.1	-0.3	-0.2	0.0	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.4	-0.5	-0.4	0.1	-0.6	-0.3	-0.2	-0.2	-0.2	0.1	-0.5
Glaucoma (self-reported)	0.1	0.1	0.4	-0.2	-0.5	0.1	0.1	0.4	-0.3	0.4	0.6	0.2	-0.0
Medication: Amlodipine	0.1	0.1	0.3	0.5	0.4	0.5	0.4	0.3	-0.1	0.3	0.2	-0.5	0.1
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.4	-0.2	0.0	0.1	-0.6	-0.2	-0.4	-0.1	0.2	-0.2	0.0
Exposure to tobacco smoke outside home	0.1	0.1	0.4	-0.4	0.0	0.6	-0.4	0.2	-0.7	0.2	0.5	0.2	0.1
Angina (self-reported)	0.1	0.1	0.4	0.6	0.4	-0.1	0.5	-0.2	0.2	-0.3	-0.3	-0.1	-0.2
Leg fat mass (right)	0.1	0.6	3.2	-0.3	-0.5	-1.8	0.5	-0.1	-1.1	-0.1	-0.0	0.7	-0.4
Comparative height size at age 10	0.1	0.7	1.4	0.9	0.9	-0.9	0.4	1.1	-0.1	1.0	0.8	1.2	0.8
Illnesses of siblings: Diabetes	0.1	0.1	0.5	0.4	0.6	0.0	0.1	-0.1	0.7	-0.1	-0.4	-0.3	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.3	1.2	0.7	0.6	-0.5	1.1	0.2	0.1	-0.1	-0.4	0.3	0.4
Qualifications: nursing, teaching	0.1	0.2	0.8	0.1	0.3	0.9	0.0	0.4	0.1	0.7	0.4	-0.1	0.7
Osteoporosis (self-reported)	0.1	0.1	0.4	-0.1	0.1	0.3	-0.5	-0.5	0.2	-0.6	-0.6	-0.3	-0.2
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.4	-0.0	0.0	-0.2	0.3	0.1	-0.3	-0.0	0.2	-0.6	-0.2
Medication: Lisinopril	0.1	0.1	0.4	0.2	0.0	0.6	-0.2	0.1	0.3	-0.0	0.3	-0.3	-0.2
Medication: Omeprazole (e.g. Zanprol)	0.1	0.2	0.5	0.2	0.0	-0.4	-0.5	0.6	0.1	0.5	0.7	0.2	0.4
Pack years of smoking	0.1	0.1	0.4	0.0	0.1	-0.7	-0.4	0.2	-0.2	0.2	0.3	-0.1	0.2
Leg fat mass (left)	0.1	0.5	3.1	-0.2	-0.4	-1.8	0.6	-0.0	-1.0	0.0	0.1	0.9	-0.3
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Chronotype (morning person)	0.0	0.1	0.5	-0.3	-0.4	0.0	-0.2	-0.2	-0.1	-0.1	-0.2	-0.7	-0.2
Systolic blood pressure, automated reading	0.0	0.1	0.4	0.0	0.0	-0.4	0.7	0.3	-0.3	0.3	0.4	-0.1	-0.2
Sitting height	0.0	0.1	0.3	0.2	0.1	-0.5	0.3	0.3	-0.3	0.1	-0.2	-0.3	0.2
Standing height	0.0	0.4	2.3	-0.3	-0.4	-1.5	-0.2	0.3	-0.9	0.2	0.1	-0.2	0.2
Length of working week for main job	0.0	0.0	0.1	0.2	-0.1	-0.3	0.2	-0.1	0.1	-0.2	-0.4	0.2	0.2
Medication: Omeprazole	0.0	0.1	0.3	0.1	-0.2	-0.4	-0.5	0.0	-0.0	-0.1	0.0	-0.2	-0.1
Handedness (chirality/laterality): Left-handed	0.0	0.0	0.1	0.1	-0.0	-0.3	0.3	0.1	-0.2	-0.1	-0.2	-0.0	0.2
Mouth/teeth dental problems: Mouth ulcers	0.0	0.1	0.2	0.0	-0.0	-0.2	0.5	0.0	-0.3	0.1	0.1	0.2	0.3

Hub : Genes

HCN3

Models

Trait associations