[Hub]/) : Traits : Crohns Disease (2017) :

chr1:154,325,302-156,572,984

Best TWAS P=2.46e-11 · Best GWAS P=6.75e-09 conditioned to 0.402

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex DAP3 0.03 0.01 blup 248 0.02 1.5e-03 5.7 5.9 3.2e-09 0.90 0.06 0.90 FALSE
2 CommonMind Brain Pre-frontal Cortex FDPS 0.04 0.04 lasso 2 0.04 3.3e-05 5.4 -5.4 5.5e-08 -0.85 0.06 0.93 FALSE
3 CommonMind Brain Pre-frontal Cortex GBAP1 0.04 0.03 blup 337 0.03 8.6e-05 -3.9 -5.7 1.5e-08 -0.65 0.59 0.33 FALSE
4 GTEx Adrenal Gland RIT1 0.24 0.03 lasso 4 0.04 1.8e-02 5.4 -5.4 7.9e-08 -0.66 0.05 0.38 FALSE
5 GTEx Adrenal Gland HCN3 0.13 0.09 lasso 2 0.05 7.1e-03 5.1 -5.2 2.4e-07 -0.86 0.05 0.61 FALSE
6 GTEx Artery Aorta GBAP1 0.31 0.36 enet 22 0.39 1.0e-22 -5.0 -5.5 2.8e-08 -0.49 0.38 0.62 FALSE
7 GTEx Artery Coronary HCN3 0.17 -0.01 lasso 6 -0.01 7.4e-01 5.4 -5.5 4.0e-08 -0.85 0.04 0.32 FALSE
8 GTEx Brain Cerebellar Hemisphere MSTO1 0.21 0.00 enet 10 0.03 4.6e-02 5.2 5.5 3.7e-08 0.63 0.07 0.52 FALSE
9 GTEx Brain Cerebellar Hemisphere DAP3 0.13 0.12 lasso 2 0.13 2.8e-04 5.2 5.2 1.6e-07 0.80 0.06 0.61 FALSE
10 GTEx Brain Cerebellum MSTO1 0.15 0.06 enet 13 0.07 4.0e-03 5.1 5.6 2.0e-08 0.65 0.12 0.57 FALSE
11 GTEx Brain Cerebellum HCN3 0.16 0.05 lasso 4 0.04 3.1e-02 5.7 -5.4 6.3e-08 -0.80 0.05 0.72 FALSE
12 GTEx Brain Cerebellum EFNA1 0.20 0.09 enet 13 0.06 9.2e-03 5.0 -5.3 1.2e-07 -0.50 0.18 0.54 FALSE
13 GTEx Cells EBV-transformed lymphocytes ADAM15 0.18 0.00 lasso 4 -0.01 7.4e-01 5.3 -5.3 1.4e-07 -0.82 0.05 0.46 FALSE
14 GTEx Cells EBV-transformed lymphocytes GBAP1 0.21 0.05 lasso 3 0.06 4.5e-03 -4.6 -6.3 2.7e-10 -0.72 0.16 0.68 FALSE
15 GTEx Cells Transformed fibroblasts ADAM15 0.14 0.01 lasso 6 0.02 9.3e-03 5.7 -6.7 2.5e-11 -0.79 0.04 0.94 TRUE
16 GTEx Cells Transformed fibroblasts RIT1 0.15 0.18 lasso 4 0.18 2.7e-13 5.4 -5.7 1.2e-08 -0.76 0.07 0.93 FALSE
17 GTEx Cells Transformed fibroblasts HCN3 0.05 0.05 lasso 5 0.06 3.8e-05 5.3 -5.5 3.0e-08 -0.80 0.06 0.93 FALSE
18 GTEx Cells Transformed fibroblasts GBAP1 0.18 0.16 lasso 6 0.15 1.6e-11 -5.0 -5.6 1.8e-08 -0.58 0.44 0.56 FALSE
19 GTEx Colon Transverse GBAP1 0.13 0.15 lasso 5 0.11 6.4e-06 -5.0 -5.5 3.0e-08 -0.55 0.34 0.66 FALSE
20 GTEx Esophagus Gastroesophageal Junction GBAP1 0.22 0.19 enet 6 0.17 6.8e-07 -4.6 -5.1 3.0e-07 -0.53 0.48 0.46 FALSE
21 GTEx Esophagus Gastroesophageal Junction GBA 0.13 0.12 lasso 6 0.11 8.7e-05 5.1 -5.2 1.7e-07 -0.85 0.06 0.90 FALSE
22 GTEx Esophagus Mucosa RIT1 0.06 0.04 lasso 8 0.03 2.9e-03 5.1 -5.4 8.1e-08 -0.84 0.07 0.90 FALSE
23 GTEx Esophagus Mucosa GBAP1 0.12 0.12 enet 22 0.09 1.7e-06 -4.9 -5.8 6.6e-09 -0.64 0.38 0.62 FALSE
24 GTEx Esophagus Mucosa GBA 0.28 0.30 enet 26 0.34 4.2e-23 4.1 -5.3 1.4e-07 -0.70 0.56 0.44 FALSE
25 GTEx Esophagus Mucosa MSTO2P 0.04 0.06 lasso 4 0.03 3.4e-03 5.2 -5.3 1.4e-07 -0.79 0.11 0.76 FALSE
26 GTEx Esophagus Muscularis RIT1 0.06 0.02 lasso 3 0.01 6.0e-02 5.1 -5.2 2.3e-07 -0.88 0.05 0.77 FALSE
27 GTEx Heart Left Ventricle GBAP1 0.18 0.22 enet 13 0.18 1.1e-09 -4.6 -5.2 2.3e-07 -0.62 0.65 0.35 FALSE
28 GTEx Lung HCN3 0.08 0.01 lasso 5 0.00 3.4e-01 5.4 -5.3 8.7e-08 -0.85 0.04 0.70 FALSE
29 GTEx Muscle Skeletal MSTO2P 0.07 0.05 lasso 2 0.05 1.1e-05 5.4 -5.3 1.4e-07 -0.82 0.08 0.90 FALSE
30 GTEx Nerve Tibial RIT1 0.12 0.10 lasso 5 0.09 8.8e-07 5.1 -5.1 3.0e-07 -0.79 0.13 0.87 FALSE
31 GTEx Nerve Tibial HCN3 0.17 0.28 lasso 6 0.25 5.8e-18 5.3 -5.3 9.4e-08 -0.76 0.07 0.92 FALSE
32 GTEx Pancreas MSTO2P 0.20 0.12 lasso 3 0.07 4.6e-04 5.2 -5.3 9.1e-08 -0.82 0.10 0.82 FALSE
33 GTEx Skin Not Sun Exposed Suprapubic FAM189B 0.09 0.00 enet 18 0.04 2.0e-03 5.3 -5.9 3.6e-09 -0.60 0.11 0.80 FALSE
34 GTEx Skin Sun Exposed Lower leg RIT1 0.09 0.09 lasso 5 0.06 5.9e-06 5.2 -5.1 2.8e-07 -0.70 0.13 0.87 FALSE
35 GTEx Small Intestine Terminal Ileum GBAP1 0.20 0.13 lasso 10 0.11 1.8e-03 5.1 -5.8 6.2e-09 -0.52 0.10 0.43 FALSE
36 GTEx Stomach GBAP1 0.09 0.12 lasso 3 0.13 1.2e-06 -4.6 -5.4 5.4e-08 -0.71 0.11 0.87 FALSE
37 GTEx Testis YY1AP1 0.54 0.34 lasso 7 0.38 4.7e-18 5.1 -5.2 2.0e-07 -0.80 0.19 0.81 FALSE
38 GTEx Thyroid GON4L 0.08 0.02 enet 28 0.00 4.0e-01 5.3 -5.4 8.2e-08 -0.74 0.05 0.70 FALSE
39 GTEx Thyroid RIT1 0.16 0.18 lasso 4 0.17 6.6e-13 5.4 -5.2 2.3e-07 -0.68 0.10 0.90 FALSE
40 GTEx Thyroid HCN3 0.05 0.05 lasso 1 0.04 5.2e-04 5.3 -5.3 1.4e-07 -0.74 0.08 0.74 FALSE
41 GTEx Thyroid FAM189B 0.08 0.10 lasso 2 0.11 5.3e-09 5.1 -5.3 1.3e-07 -0.77 0.15 0.85 FALSE
42 GTEx Thyroid MSTO2P 0.05 0.05 lasso 5 0.04 6.2e-04 5.7 -5.8 8.2e-09 -0.93 0.04 0.95 FALSE
43 METSIM Adipose DAP3 0.03 0.03 enet 16 0.04 8.3e-07 5.2 -5.4 7.1e-08 -0.67 0.12 0.88 FALSE
44 METSIM Adipose EFNA1 0.04 0.02 blup 350 0.02 8.5e-04 2.9 -5.5 3.7e-08 -0.57 0.63 0.20 FALSE
45 METSIM Adipose THBS3 0.09 0.10 lasso 7 0.12 4.7e-17 -5.0 5.9 4.6e-09 0.76 0.34 0.66 FALSE
46 NTR Blood THBS3 0.03 0.02 blup 341 0.02 2.8e-08 -4.6 5.5 4.0e-08 0.76 0.24 0.75 FALSE
47 YFS Blood ADAM15 0.58 0.15 bslmm 373 0.40 3.7e-144 -5.2 -6.3 2.7e-10 -0.36 0.15 0.85 FALSE
48 YFS Blood DAP3 0.02 0.03 lasso 5 0.03 4.4e-09 5.2 -5.3 9.5e-08 -0.82 0.13 0.87 FALSE
49 YFS Blood FAM189B 0.02 0.01 bslmm 312 0.02 3.2e-06 5.0 5.5 2.9e-08 0.71 0.20 0.80 FALSE
50 YFS Blood SYT11 0.01 0.01 lasso 4 0.01 2.8e-05 5.5 -5.6 2.2e-08 -0.90 0.02 0.98 FALSE
51 The Cancer Genome Atlas Breast Invasive Carcinoma GBA 0.03 0.00 blup 26 0.02 3.1e-04 5.3 -5.8 7.5e-09 -0.69 0.02 0.84 FALSE
52 The Cancer Genome Atlas Breast Invasive Carcinoma GBAP1 0.02 0.03 lasso 4 0.03 1.3e-07 -5.0 -5.6 1.9e-08 -0.66 0.02 0.97 FALSE
53 The Cancer Genome Atlas Breast Invasive Carcinoma MSTO2P 0.02 0.02 lasso 2 0.01 1.0e-03 5.7 -5.7 1.4e-08 -0.89 0.00 0.98 FALSE
54 The Cancer Genome Atlas Breast Invasive Carcinoma RIT1 0.02 0.01 blup 39 0.02 3.1e-04 5.2 -5.5 3.7e-08 -0.76 0.01 0.98 FALSE
55 The Cancer Genome Atlas Breast Invasive Carcinoma THBS3 0.02 0.02 blup 26 0.02 4.0e-05 -4.6 5.5 4.1e-08 0.57 0.02 0.96 FALSE
56 The Cancer Genome Atlas Breast Invasive Carcinoma YY1AP1 0.03 0.01 enet 3 0.01 1.6e-03 5.2 -5.6 1.7e-08 -0.90 0.01 0.88 FALSE
57 The Cancer Genome Atlas Colon Adenocarcinoma HCN3 0.08 0.00 lasso 3 0.00 5.7e-01 4.0 -5.8 8.2e-09 -0.58 0.01 0.38 FALSE
58 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma GBA 0.04 0.01 blup 26 0.01 8.3e-03 5.2 -5.7 1.4e-08 -0.77 0.01 0.70 FALSE
59 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma GBAP1 0.04 0.04 blup 26 0.04 2.5e-05 5.0 -5.4 5.3e-08 -0.63 0.02 0.97 FALSE
60 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma HCN3 0.03 0.03 lasso 1 0.03 2.3e-04 5.3 -5.3 1.1e-07 -0.81 0.01 0.94 FALSE
61 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma RIT1 0.05 0.07 enet 6 0.06 1.6e-04 5.1 -5.2 1.8e-07 -0.88 0.01 0.93 FALSE
62 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma THBS3 0.04 0.02 enet 8 0.01 4.5e-02 5.0 5.6 1.8e-08 0.66 0.01 0.70 FALSE
63 The Cancer Genome Atlas Brain Lower Grade Glioma GBAP1 0.03 0.01 blup 26 0.02 1.9e-03 5.0 -5.5 4.7e-08 -0.54 0.02 0.90 FALSE
64 The Cancer Genome Atlas Brain Lower Grade Glioma RAG1AP1 0.07 0.05 blup 77 0.05 3.8e-06 3.5 5.1 2.8e-07 0.52 0.19 0.80 FALSE
65 The Cancer Genome Atlas Lung Adenocarcinoma MSTO2P 0.05 0.03 lasso 3 0.03 4.9e-04 5.7 -5.7 1.3e-08 -0.89 0.00 0.98 FALSE
66 The Cancer Genome Atlas Lung Squamous Cell Carcinoma GBA 0.02 0.00 blup 27 0.01 1.2e-02 5.2 -5.7 1.6e-08 -0.74 0.01 0.47 FALSE
67 The Cancer Genome Atlas Lung Squamous Cell Carcinoma GBAP1 0.04 0.02 blup 27 0.03 4.7e-04 -4.9 -5.3 9.0e-08 -0.66 0.02 0.72 FALSE
68 The Cancer Genome Atlas Prostate Adenocarcinoma FDPS 0.02 0.02 lasso 2 0.01 1.6e-02 5.3 -5.3 1.1e-07 -0.75 0.01 0.65 FALSE
69 The Cancer Genome Atlas Prostate Adenocarcinoma MSTO1 0.03 0.03 blup 6 0.03 2.1e-04 5.1 -5.3 9.0e-08 -0.86 0.00 0.98 FALSE
70 The Cancer Genome Atlas Prostate Adenocarcinoma RIT1 0.05 0.05 lasso 4 0.04 2.2e-05 5.3 -5.4 8.0e-08 -0.70 0.01 0.98 FALSE
71 The Cancer Genome Atlas Thyroid Carcinoma GBAP1 0.02 0.01 blup 24 0.02 3.0e-03 -4.9 -5.9 4.6e-09 -0.65 0.01 0.57 FALSE