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chr1:154,325,302-156,572,984

Best TWAS P=2.46e-11 · Best GWAS P=6.75e-09 conditioned to 0.402

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	DAP3	0.03	0.01	blup	248	0.02	1.5e-03	5.7	5.9	3.2e-09	0.90	0.06	0.90	FALSE
2	CommonMind	Brain Pre-frontal Cortex	FDPS	0.04	0.04	lasso	2	0.04	3.3e-05	5.4	-5.4	5.5e-08	-0.85	0.06	0.93	FALSE
3	CommonMind	Brain Pre-frontal Cortex	GBAP1	0.04	0.03	blup	337	0.03	8.6e-05	-3.9	-5.7	1.5e-08	-0.65	0.59	0.33	FALSE
4	GTEx	Adrenal Gland	RIT1	0.24	0.03	lasso	4	0.04	1.8e-02	5.4	-5.4	7.9e-08	-0.66	0.05	0.38	FALSE
5	GTEx	Adrenal Gland	HCN3	0.13	0.09	lasso	2	0.05	7.1e-03	5.1	-5.2	2.4e-07	-0.86	0.05	0.61	FALSE
6	GTEx	Artery Aorta	GBAP1	0.31	0.36	enet	22	0.39	1.0e-22	-5.0	-5.5	2.8e-08	-0.49	0.38	0.62	FALSE
7	GTEx	Artery Coronary	HCN3	0.17	-0.01	lasso	6	-0.01	7.4e-01	5.4	-5.5	4.0e-08	-0.85	0.04	0.32	FALSE
8	GTEx	Brain Cerebellar Hemisphere	MSTO1	0.21	0.00	enet	10	0.03	4.6e-02	5.2	5.5	3.7e-08	0.63	0.07	0.52	FALSE
9	GTEx	Brain Cerebellar Hemisphere	DAP3	0.13	0.12	lasso	2	0.13	2.8e-04	5.2	5.2	1.6e-07	0.80	0.06	0.61	FALSE
10	GTEx	Brain Cerebellum	MSTO1	0.15	0.06	enet	13	0.07	4.0e-03	5.1	5.6	2.0e-08	0.65	0.12	0.57	FALSE
11	GTEx	Brain Cerebellum	HCN3	0.16	0.05	lasso	4	0.04	3.1e-02	5.7	-5.4	6.3e-08	-0.80	0.05	0.72	FALSE
12	GTEx	Brain Cerebellum	EFNA1	0.20	0.09	enet	13	0.06	9.2e-03	5.0	-5.3	1.2e-07	-0.50	0.18	0.54	FALSE
13	GTEx	Cells EBV-transformed lymphocytes	ADAM15	0.18	0.00	lasso	4	-0.01	7.4e-01	5.3	-5.3	1.4e-07	-0.82	0.05	0.46	FALSE
14	GTEx	Cells EBV-transformed lymphocytes	GBAP1	0.21	0.05	lasso	3	0.06	4.5e-03	-4.6	-6.3	2.7e-10	-0.72	0.16	0.68	FALSE
15	GTEx	Cells Transformed fibroblasts	ADAM15	0.14	0.01	lasso	6	0.02	9.3e-03	5.7	-6.7	2.5e-11	-0.79	0.04	0.94	TRUE
16	GTEx	Cells Transformed fibroblasts	RIT1	0.15	0.18	lasso	4	0.18	2.7e-13	5.4	-5.7	1.2e-08	-0.76	0.07	0.93	FALSE
17	GTEx	Cells Transformed fibroblasts	HCN3	0.05	0.05	lasso	5	0.06	3.8e-05	5.3	-5.5	3.0e-08	-0.80	0.06	0.93	FALSE
18	GTEx	Cells Transformed fibroblasts	GBAP1	0.18	0.16	lasso	6	0.15	1.6e-11	-5.0	-5.6	1.8e-08	-0.58	0.44	0.56	FALSE
19	GTEx	Colon Transverse	GBAP1	0.13	0.15	lasso	5	0.11	6.4e-06	-5.0	-5.5	3.0e-08	-0.55	0.34	0.66	FALSE
20	GTEx	Esophagus Gastroesophageal Junction	GBAP1	0.22	0.19	enet	6	0.17	6.8e-07	-4.6	-5.1	3.0e-07	-0.53	0.48	0.46	FALSE
21	GTEx	Esophagus Gastroesophageal Junction	GBA	0.13	0.12	lasso	6	0.11	8.7e-05	5.1	-5.2	1.7e-07	-0.85	0.06	0.90	FALSE
22	GTEx	Esophagus Mucosa	RIT1	0.06	0.04	lasso	8	0.03	2.9e-03	5.1	-5.4	8.1e-08	-0.84	0.07	0.90	FALSE
23	GTEx	Esophagus Mucosa	GBAP1	0.12	0.12	enet	22	0.09	1.7e-06	-4.9	-5.8	6.6e-09	-0.64	0.38	0.62	FALSE
24	GTEx	Esophagus Mucosa	GBA	0.28	0.30	enet	26	0.34	4.2e-23	4.1	-5.3	1.4e-07	-0.70	0.56	0.44	FALSE
25	GTEx	Esophagus Mucosa	MSTO2P	0.04	0.06	lasso	4	0.03	3.4e-03	5.2	-5.3	1.4e-07	-0.79	0.11	0.76	FALSE
26	GTEx	Esophagus Muscularis	RIT1	0.06	0.02	lasso	3	0.01	6.0e-02	5.1	-5.2	2.3e-07	-0.88	0.05	0.77	FALSE
27	GTEx	Heart Left Ventricle	GBAP1	0.18	0.22	enet	13	0.18	1.1e-09	-4.6	-5.2	2.3e-07	-0.62	0.65	0.35	FALSE
28	GTEx	Lung	HCN3	0.08	0.01	lasso	5	0.00	3.4e-01	5.4	-5.3	8.7e-08	-0.85	0.04	0.70	FALSE
29	GTEx	Muscle Skeletal	MSTO2P	0.07	0.05	lasso	2	0.05	1.1e-05	5.4	-5.3	1.4e-07	-0.82	0.08	0.90	FALSE
30	GTEx	Nerve Tibial	RIT1	0.12	0.10	lasso	5	0.09	8.8e-07	5.1	-5.1	3.0e-07	-0.79	0.13	0.87	FALSE
31	GTEx	Nerve Tibial	HCN3	0.17	0.28	lasso	6	0.25	5.8e-18	5.3	-5.3	9.4e-08	-0.76	0.07	0.92	FALSE
32	GTEx	Pancreas	MSTO2P	0.20	0.12	lasso	3	0.07	4.6e-04	5.2	-5.3	9.1e-08	-0.82	0.10	0.82	FALSE
33	GTEx	Skin Not Sun Exposed Suprapubic	FAM189B	0.09	0.00	enet	18	0.04	2.0e-03	5.3	-5.9	3.6e-09	-0.60	0.11	0.80	FALSE
34	GTEx	Skin Sun Exposed Lower leg	RIT1	0.09	0.09	lasso	5	0.06	5.9e-06	5.2	-5.1	2.8e-07	-0.70	0.13	0.87	FALSE
35	GTEx	Small Intestine Terminal Ileum	GBAP1	0.20	0.13	lasso	10	0.11	1.8e-03	5.1	-5.8	6.2e-09	-0.52	0.10	0.43	FALSE
36	GTEx	Stomach	GBAP1	0.09	0.12	lasso	3	0.13	1.2e-06	-4.6	-5.4	5.4e-08	-0.71	0.11	0.87	FALSE
37	GTEx	Testis	YY1AP1	0.54	0.34	lasso	7	0.38	4.7e-18	5.1	-5.2	2.0e-07	-0.80	0.19	0.81	FALSE
38	GTEx	Thyroid	GON4L	0.08	0.02	enet	28	0.00	4.0e-01	5.3	-5.4	8.2e-08	-0.74	0.05	0.70	FALSE
39	GTEx	Thyroid	RIT1	0.16	0.18	lasso	4	0.17	6.6e-13	5.4	-5.2	2.3e-07	-0.68	0.10	0.90	FALSE
40	GTEx	Thyroid	HCN3	0.05	0.05	lasso	1	0.04	5.2e-04	5.3	-5.3	1.4e-07	-0.74	0.08	0.74	FALSE
41	GTEx	Thyroid	FAM189B	0.08	0.10	lasso	2	0.11	5.3e-09	5.1	-5.3	1.3e-07	-0.77	0.15	0.85	FALSE
42	GTEx	Thyroid	MSTO2P	0.05	0.05	lasso	5	0.04	6.2e-04	5.7	-5.8	8.2e-09	-0.93	0.04	0.95	FALSE
43	METSIM	Adipose	DAP3	0.03	0.03	enet	16	0.04	8.3e-07	5.2	-5.4	7.1e-08	-0.67	0.12	0.88	FALSE
44	METSIM	Adipose	EFNA1	0.04	0.02	blup	350	0.02	8.5e-04	2.9	-5.5	3.7e-08	-0.57	0.63	0.20	FALSE
45	METSIM	Adipose	THBS3	0.09	0.10	lasso	7	0.12	4.7e-17	-5.0	5.9	4.6e-09	0.76	0.34	0.66	FALSE
46	NTR	Blood	THBS3	0.03	0.02	blup	341	0.02	2.8e-08	-4.6	5.5	4.0e-08	0.76	0.24	0.75	FALSE
47	YFS	Blood	ADAM15	0.58	0.15	bslmm	373	0.40	3.7e-144	-5.2	-6.3	2.7e-10	-0.36	0.15	0.85	FALSE
48	YFS	Blood	DAP3	0.02	0.03	lasso	5	0.03	4.4e-09	5.2	-5.3	9.5e-08	-0.82	0.13	0.87	FALSE
49	YFS	Blood	FAM189B	0.02	0.01	bslmm	312	0.02	3.2e-06	5.0	5.5	2.9e-08	0.71	0.20	0.80	FALSE
50	YFS	Blood	SYT11	0.01	0.01	lasso	4	0.01	2.8e-05	5.5	-5.6	2.2e-08	-0.90	0.02	0.98	FALSE
51	The Cancer Genome Atlas	Breast Invasive Carcinoma	GBA	0.03	0.00	blup	26	0.02	3.1e-04	5.3	-5.8	7.5e-09	-0.69	0.02	0.84	FALSE
52	The Cancer Genome Atlas	Breast Invasive Carcinoma	GBAP1	0.02	0.03	lasso	4	0.03	1.3e-07	-5.0	-5.6	1.9e-08	-0.66	0.02	0.97	FALSE
53	The Cancer Genome Atlas	Breast Invasive Carcinoma	MSTO2P	0.02	0.02	lasso	2	0.01	1.0e-03	5.7	-5.7	1.4e-08	-0.89	0.00	0.98	FALSE
54	The Cancer Genome Atlas	Breast Invasive Carcinoma	RIT1	0.02	0.01	blup	39	0.02	3.1e-04	5.2	-5.5	3.7e-08	-0.76	0.01	0.98	FALSE
55	The Cancer Genome Atlas	Breast Invasive Carcinoma	THBS3	0.02	0.02	blup	26	0.02	4.0e-05	-4.6	5.5	4.1e-08	0.57	0.02	0.96	FALSE
56	The Cancer Genome Atlas	Breast Invasive Carcinoma	YY1AP1	0.03	0.01	enet	3	0.01	1.6e-03	5.2	-5.6	1.7e-08	-0.90	0.01	0.88	FALSE
57	The Cancer Genome Atlas	Colon Adenocarcinoma	HCN3	0.08	0.00	lasso	3	0.00	5.7e-01	4.0	-5.8	8.2e-09	-0.58	0.01	0.38	FALSE
58	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GBA	0.04	0.01	blup	26	0.01	8.3e-03	5.2	-5.7	1.4e-08	-0.77	0.01	0.70	FALSE
59	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GBAP1	0.04	0.04	blup	26	0.04	2.5e-05	5.0	-5.4	5.3e-08	-0.63	0.02	0.97	FALSE
60	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	HCN3	0.03	0.03	lasso	1	0.03	2.3e-04	5.3	-5.3	1.1e-07	-0.81	0.01	0.94	FALSE
61	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	RIT1	0.05	0.07	enet	6	0.06	1.6e-04	5.1	-5.2	1.8e-07	-0.88	0.01	0.93	FALSE
62	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	THBS3	0.04	0.02	enet	8	0.01	4.5e-02	5.0	5.6	1.8e-08	0.66	0.01	0.70	FALSE
63	The Cancer Genome Atlas	Brain Lower Grade Glioma	GBAP1	0.03	0.01	blup	26	0.02	1.9e-03	5.0	-5.5	4.7e-08	-0.54	0.02	0.90	FALSE
64	The Cancer Genome Atlas	Brain Lower Grade Glioma	RAG1AP1	0.07	0.05	blup	77	0.05	3.8e-06	3.5	5.1	2.8e-07	0.52	0.19	0.80	FALSE
65	The Cancer Genome Atlas	Lung Adenocarcinoma	MSTO2P	0.05	0.03	lasso	3	0.03	4.9e-04	5.7	-5.7	1.3e-08	-0.89	0.00	0.98	FALSE
66	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	GBA	0.02	0.00	blup	27	0.01	1.2e-02	5.2	-5.7	1.6e-08	-0.74	0.01	0.47	FALSE
67	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	GBAP1	0.04	0.02	blup	27	0.03	4.7e-04	-4.9	-5.3	9.0e-08	-0.66	0.02	0.72	FALSE
68	The Cancer Genome Atlas	Prostate Adenocarcinoma	FDPS	0.02	0.02	lasso	2	0.01	1.6e-02	5.3	-5.3	1.1e-07	-0.75	0.01	0.65	FALSE
69	The Cancer Genome Atlas	Prostate Adenocarcinoma	MSTO1	0.03	0.03	blup	6	0.03	2.1e-04	5.1	-5.3	9.0e-08	-0.86	0.00	0.98	FALSE
70	The Cancer Genome Atlas	Prostate Adenocarcinoma	RIT1	0.05	0.05	lasso	4	0.04	2.2e-05	5.3	-5.4	8.0e-08	-0.70	0.01	0.98	FALSE
71	The Cancer Genome Atlas	Thyroid Carcinoma	GBAP1	0.02	0.01	blup	24	0.02	3.0e-03	-4.9	-5.9	4.6e-09	-0.65	0.01	0.57	FALSE