TWAS hub - SYT11

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Thyroid	0.0860	0.0490	0.00750	0.00	NA	0.023	NA	0.005	0.33000	NA	0.00700	NA	1.3e-01
2	YFS	Blood	0.0111	0.0053	0.00072	0.01	0.008	0.010	0.008	0.013	0.00016	0.001	0.00026	0.001	2.8e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Crohns Disease (2017)	11.0	24.2	31.2	-4.1	-5.6
Crohns Disease (2012)	10.9	17.6	27.4	-2.8	-5.2
Breast Cancer	9.4	22.6	27.0	5.2	4.3
Irritable Bowel Disease (IBD)	7.8	18.5	26.6	-3.2	-5.2
Time employed in main current job	4.6	5.3	6.0	2.4	2.1
Allergy or Eczema	4.1	10.9	14.0	-2.8	-3.7
LDL Cholesterol	4.0	6.3	6.6	2.6	-2.4
Body Mass Index (BMI) (2010)	3.8	5.2	8.8	1.3	3.0
Frequency of depressed mood in last 2 weeks	3.7	5.2	5.9	-2.1	-2.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.7	4.4	5.2	-1.9	-2.3
Medication: Ramipril	3.6	4.6	8.4	-0.9	-2.9
Birth weight	3.6	7.8	15.4	0.3	3.9
High blood pressure (mother)	3.3	4.6	8.1	1.0	2.8
Seen a psychiatrist for nerves, anxiety, tension or depression	3.3	4.2	4.8	-2.2	-1.9
Hayfever, allergic rhinitis or eczema	3.2	7.0	9.5	-2.1	-3.1
Allergy	3.1	7.1	11.8	1.5	3.4
Mouth/teeth dental problems: Loose teeth	3.1	3.6	3.7	-1.9	-1.9
Medication: Ibuprofen (e.g. Nurofen)	3.0	3.8	7.0	0.7	2.6
Number of full brothers	3.0	3.8	7.6	0.2	-2.8
Guilty feelings	3.0	4.6	5.4	-1.9	-2.3
Pain experienced in last month	2.9	4.9	9.2	0.7	-3.0
Loud music exposure frequency	2.8	3.0	3.4	-1.8	1.6
Heart disease (mother)	2.8	3.4	5.8	1.0	2.4
Risk taking	2.8	4.1	8.0	-0.4	-2.8
Impedance of leg (left)	2.7	13.0	25.5	-0.7	-5.0
Had other major operations	2.7	3.3	5.9	-2.4	-0.8
Medication for cholesterol, blood pressure or diabetes	2.7	4.4	6.0	1.7	2.5
Emphysema/chronic bronchitis	2.7	3.1	4.7	-2.2	-1.2
Ulcerative Colitis (UC)	2.6	4.8	8.6	-1.1	-2.9
Impedance of leg (right)	2.6	12.7	25.3	-0.1	-5.0
Nervous feelings	2.6	4.8	9.5	0.5	3.1
Hayfever/allergic rhinitis (self-reported)	2.6	3.4	5.7	-1.1	-2.4
Miserableness	2.6	4.5	4.9	-2.0	-2.2
Myopia	2.5	3.6	4.5	1.6	-2.1
Commuting to job workplace: Public transport	2.4	2.8	5.6	0.2	2.4
Respiratory disease	2.3	5.0	5.3	-2.2	-2.3
Illnesses of mother	2.3	2.8	5.1	-0.7	-2.3
Reason for reducing amount of alcohol drunk: Health precaution	2.3	2.7	2.9	1.6	-1.7
Medication: Ibuprofen	2.3	2.8	5.5	0.3	2.3
Bipolar Disorder (2018)	2.1	3.3	3.8	-1.7	-1.9
Qualifications: CSEs or equivalent	2.1	2.8	3.9	-2.0	-1.3
Eye problems/disorders: None of the above	2.1	2.5	4.9	0.1	2.2
Illnesses of father: None of the above (group 1)	2.1	2.6	4.3	-0.9	-2.1
Happiness	2.0	2.4	4.7	-2.2	-0.4
Pulse wave Arterial Stiffness index	2.0	2.3	4.4	-0.5	-2.1
Medication: Blood pressure	2.0	3.5	5.1	-1.4	-2.2
Family relationship satisfaction	2.0	2.5	3.3	-1.3	-1.8
Worrier / anxious feelings	1.9	3.5	6.6	-0.6	2.6
Frequency of tiredness / lethargy in last 2 weeks	1.9	3.2	3.9	-2.0	-1.6
Illnesses of father: Heart disease	1.9	2.6	4.1	-1.1	2.0
Age started oral contraceptive pill	1.9	2.3	2.6	1.4	1.6
Bipolar Disorder or Schizophrenia	1.8	4.5	5.9	-1.7	-2.4
Depression (Nagel 2018)	1.8	2.8	3.1	-1.6	-1.8
Pulse wave peak to peak time	1.8	2.1	4.0	0.4	2.0
Reaction Time	1.7	3.2	3.8	-1.9	-1.6
Had menopause	1.7	2.1	2.2	1.4	1.5
Pain all over the body in last month	1.7	1.8	3.6	0.0	1.9
Leg pain on walking	1.7	2.2	2.6	1.6	1.3
Townsend deprivation index at recruitment	1.6	2.3	2.4	1.6	-1.5
Financial difficulties in last 2 years	1.6	2.2	3.5	0.9	1.9
Mouth/teeth dental problems	1.6	2.5	3.2	1.8	1.3
Comparative body size at age 10	1.6	4.5	8.5	0.6	2.9
Chest pain or discomfort	1.6	2.4	3.8	-1.0	-1.9
Number of self-reported non-cancer illnesses	1.6	2.8	3.5	-1.4	-1.9
Lupus	1.5	2.3	2.7	-1.6	1.4
Ever had hysterectomy (womb removed)	1.5	1.7	3.2	1.8	0.3
Arm fat percentage (right)	1.5	6.0	11.7	-0.5	3.4
Mouth/teeth dental problems: Dentures	1.5	2.6	4.1	-2.0	-1.0
Supplements: Vitamin C	1.5	1.8	3.0	0.7	1.7
Ever depressed for a whole week	1.5	1.8	2.6	-1.6	-1.0
Number of children fathered	1.4	1.6	2.3	-0.9	-1.5
Mean time to correctly identify matches	1.4	2.8	4.6	-2.1	-1.0
Medication for cholesterol	1.4	2.2	4.1	-2.0	0.5
Fractured/broken bones in last 5 years	1.4	1.8	2.3	-1.1	-1.5
Type 2 Diabetes (T2D) (2012)	1.3	1.5	2.9	-0.4	-1.7
Current tobacco smoking	1.3	2.2	3.0	-1.2	-1.7
Chronic bronchitis/emphysema (father)	1.3	1.6	1.9	1.4	1.1
Arm fat mass (right)	1.3	5.5	10.7	-0.7	3.3
Medication: Seretide 50 evohaler	1.3	1.5	2.3	1.5	0.8
Asthma (self-reported)	1.3	2.5	4.7	-0.6	-2.2
Number of operations (self-reported)	1.3	1.9	3.5	-1.9	-0.6
Prostate Cancer	1.2	1.7	3.3	-1.8	0.1
Schizophrenia (2014)	1.2	2.7	2.9	-1.6	-1.7
BMI	1.2	7.0	14.0	-0.0	3.7
Medication for hormone replacement therapy	1.2	1.4	2.8	1.7	0.0
Tinnitus: Yes, but not now, but have in the past	1.2	1.2	1.8	0.8	1.4
Body mass index (BMI)	1.2	5.0	10.0	-0.1	3.2
Number of incorrect matches in round	1.2	2.0	3.9	-2.0	0.1
Tense / ‘highly strung’	1.2	2.0	3.9	-0.2	-2.0
Illness, injury, bereavement, stress in last 2 years	1.2	1.4	2.2	-1.5	-0.8
Arm fat percentage (left)	1.2	4.7	8.7	-0.8	3.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.5	1.5	1.2	1.2
Smoking status: Current	1.2	1.9	2.2	-1.5	-1.2
Ever taken oral contraceptive pill	1.2	1.4	2.7	-0.2	-1.6
Diastolic blood pressure, automated reading	1.2	3.6	6.0	2.5	1.1
Impedance of whole body	1.2	6.1	11.4	-0.9	-3.4
Age at First Birth	1.1	1.6	3.1	-1.8	0.4
Ever used hormone-replacement therapy (HRT)	1.1	1.4	2.4	1.6	0.6
Asthma	1.1	2.1	4.2	-0.3	-2.0
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.6	3.3	-1.8	0.0
Age at first live birth	1.1	1.9	3.9	0.0	2.0
Migraine (self-reported)	1.1	1.3	2.4	-0.5	1.5
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.2	1.7	-0.9	-1.3
Arm fat mass (left)	1.1	4.5	8.6	-0.6	2.9
Medication: Atorvastatin	1.1	1.4	2.5	-0.5	-1.6
Basal cell carcinoma (self-reported)	1.1	1.3	2.6	0.0	1.6
Depressed Affect (Nagel 2018)	1.0	2.1	3.5	-0.9	-1.9
Mean Putamen Volume	1.0	1.1	2.2	0.1	-1.5
Fasting Glucose	1.0	1.2	1.5	1.0	-1.2
Medication: Co-codamol	1.0	1.2	1.8	1.4	0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.4	1.5	-1.1	-1.2
Leg predicted mass (left)	1.0	5.2	10.4	-0.2	3.2
Qualifications: None of the above	1.0	2.1	2.4	1.3	1.5
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.2	1.4	-1.0	-1.2
Lung cancer (father)	1.0	1.2	1.9	-0.7	-1.4
Pulse wave reflection index	1.0	1.2	1.7	-0.9	-1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.1	1.1	-1.1	-1.1
Leg fat-free mass (right)	1.0	5.4	10.4	-0.5	3.2
Eye problems/disorders: Cataract	1.0	1.2	2.3	0.2	-1.5
Mineral and other dietary supplements	1.0	1.3	2.2	1.5	0.6
Leg predicted mass (right)	1.0	5.4	10.4	-0.6	3.2
Illnesses of father: High blood pressure	1.0	1.3	2.4	1.6	0.3
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	2.6	-0.2	-1.6
Coronary Artery Disease (CAD)	0.9	1.1	1.7	1.3	0.7
HDL Cholesterol	0.9	1.5	2.3	1.5	0.8
Hair Pigment	0.9	24.8	47.2	1.6	-6.9
Tanning	0.9	10.9	11.9	-3.1	-3.5
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	1.5	-1.2	-0.9
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	1.3	1.1	0.8
Leg fat-free mass (left)	0.9	4.7	9.4	-0.2	3.1
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	1.7	-1.3	-1.1
Alcohol intake versus 10 years previously	0.9	1.4	2.4	0.5	-1.6
Birth weight of first child	0.9	1.6	2.0	-1.4	1.0
Smoking status: Previous	0.9	1.4	2.1	0.8	-1.4
Long-standing illness, disability or infirmity	0.9	1.4	2.8	-1.7	-0.2
Friendships satisfaction	0.9	1.2	2.2	-0.4	-1.5
Heart disease (siblings)	0.9	1.1	1.8	-0.6	1.3
Schizophrenia (2018)	0.8	1.7	2.4	-1.0	-1.6
Smoking Status	0.8	1.9	2.7	-1.0	-1.7
Cardiovascular Disease	0.8	2.8	5.1	0.7	-2.2
Lung FVC	0.8	4.2	8.3	-0.3	2.9
Sensitivity / hurt feelings	0.8	1.3	2.1	-1.5	0.7
Systolic blood pressure, automated reading	0.8	2.4	4.5	2.1	0.6
Qualifications: A levels/AS levels or equivalent	0.8	1.7	3.5	1.9	0.0
Medication: Cholesterol lowering	0.8	1.2	2.0	-1.4	-0.5
Blood clot in the leg (DVT)	0.8	1.1	2.2	-0.1	-1.5
Medication: Paracetamol	0.8	1.3	2.3	0.6	1.5
Headache pain in last month	0.8	1.4	2.7	-1.6	0.4
Worry too long after embarrassment	0.8	1.3	2.0	-0.8	-1.4
Medication for pain relief, constipation, heartburn	0.8	1.3	2.5	0.3	-1.6
Number of full sisters	0.8	1.0	1.9	-1.4	-0.1
Mouth/teeth dental problems: Mouth ulcers	0.8	1.2	2.1	0.7	-1.4
Hearing aid user	0.8	0.9	1.4	-1.2	0.6
Financial situation satisfaction	0.8	1.0	1.9	-0.2	-1.4
Cholesterol lowering medication	0.8	1.2	2.1	1.4	-0.6
Alcohol drinker status: Previous	0.8	0.9	1.8	-0.2	-1.4
Neuroticism (Nagel 2018)	0.7	1.5	2.0	-1.4	-1.0
Waist Hip Ratio (WHR)	0.7	2.9	3.5	-1.9	-1.5
Systolic Blood Pressure	0.7	3.7	5.4	2.3	-1.4
Hand grip strength (left)	0.7	2.0	2.7	-1.6	-1.1
Angina	0.7	0.9	1.7	-1.3	-0.3
Relative age voice broke	0.7	1.0	2.0	-0.3	-1.4
Falls in the last year	0.7	0.9	1.4	1.2	-0.7
Pulse rate	0.7	1.3	2.2	-0.5	-1.5
Depression (self-reported)	0.7	0.8	1.3	-1.1	-0.6
Prospective memory result	0.7	0.9	1.7	-1.3	0.3
High blood pressure (siblings)	0.7	1.0	1.9	0.4	1.4
Whole body fat mass	0.7	2.7	4.6	-0.9	2.1
Alcohol intake frequency.	0.7	1.6	2.9	-0.5	1.7
Loneliness, isolation	0.7	1.0	2.0	0.0	-1.4
Breast cancer (self-reported)	0.7	0.8	1.5	-0.4	-1.2
Medication: Aspirin	0.7	1.0	1.9	-1.4	0.0
Tinnitus: Yes, now most or all of the time	0.7	0.8	1.1	1.1	-0.7
Irritability	0.7	1.3	2.5	-0.1	-1.6
Alzheimer’s Disease (in father)	0.6	0.7	0.9	0.7	1.0
Primary Biliary Cirrhosis	0.6	0.8	0.8	0.9	-0.9
Chronotype (morning person)	0.6	1.4	1.7	1.3	-1.1
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	0.7	-0.8	0.9
Past tobacco smoking	0.6	1.1	2.2	0.0	1.5
Alcohol usually taken with meals	0.6	1.0	1.9	-1.4	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.3	1.8	-0.9	-1.4
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.4	-1.2	0.1
Heart attack	0.6	0.7	1.2	-0.6	-1.1
Peak expiratory flow (PEF)	0.6	1.3	2.6	-0.0	1.6
Average weekly red wine intake	0.6	0.9	1.7	-0.3	-1.3
Mother’s age at death	0.6	0.7	1.1	0.6	1.1
Medication: Paracetamol	0.6	0.9	1.8	-0.0	1.3
Vascular/heart problems diagnosed by doctor	0.6	1.6	3.2	-0.1	1.8
Pack years of smoking	0.6	0.9	1.4	-1.2	-0.5
Alzheimer’s Disease (in mother)	0.5	0.6	1.1	-0.2	-1.1
Ulcerative Colitis	0.5	0.7	1.4	0.0	-1.2
Hearing difficulty/problems: Yes	0.5	0.7	1.4	1.2	-0.2
Diabetes (mother)	0.5	0.6	1.2	-1.1	0.0
Severe depression (siblings)	0.5	0.6	0.9	-0.5	-1.0
Pack years adult smoking proportion	0.5	0.8	1.3	-1.1	-0.5
Trunk fat percentage	0.5	1.9	2.6	-1.1	1.6
Fed-up feelings	0.5	0.9	1.6	-0.3	-1.3
Trunk fat mass	0.5	2.3	3.4	-1.1	1.9
Hair/balding pattern: Pattern 2	0.5	0.6	1.3	0.1	-1.1
Weight	0.5	2.5	4.7	-0.5	2.2
Medication: Lansoprazole	0.5	0.6	1.0	0.5	-1.0
Gout (self-reported)	0.5	0.7	0.9	-1.0	-0.7
Neck or shoulder pain in last month	0.5	0.8	1.5	0.2	1.2
Angina (self-reported)	0.5	0.7	1.3	-1.2	-0.0
Had major operations	0.5	0.6	1.1	-1.1	-0.2
Whole body fat-free mass	0.5	2.6	5.2	0.1	2.3
Back pain experienced in last month	0.5	0.8	0.8	-0.8	0.9
Medication: Gliclazide	0.5	0.6	0.9	-1.0	-0.6
Whole body water mass	0.5	2.6	5.3	0.0	2.3
Medication: Blood pressure	0.5	0.9	1.0	0.9	-1.0
Basal metabolic rate	0.5	2.8	5.6	-0.2	2.4
Average weekly beer plus cider intake	0.5	0.7	0.7	0.8	0.8
Commuting to job workplace: Cycle	0.5	0.6	0.8	-0.9	0.7
Schizophrenia vs Biploar Disorder	0.4	0.5	0.8	0.9	0.3
Worry (Nagel 2018)	0.4	0.8	1.2	-0.7	1.1
Ovarian Cancer	0.4	0.5	0.5	-0.7	-0.6
Neuroticism (2016)	0.4	0.5	0.6	-0.8	-0.6
Relative age of first facial hair	0.4	0.9	1.8	-1.3	-0.1
Father’s age at death	0.4	0.6	0.8	0.9	0.6
Forced expiratory volume in 1-second (FEV1)	0.4	1.4	2.1	-1.5	0.8
Noisy workplace	0.4	0.5	0.5	-0.7	0.7
Exposure to tobacco smoke at home	0.4	0.5	0.8	-0.4	0.9
Ever highly irritable/argumentative for 2 days	0.4	0.5	0.9	-0.9	-0.3
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	0.9	-0.4	-1.0
Body fat percentage	0.4	1.6	2.5	-0.9	1.6
Age at last live birth	0.4	0.6	1.1	-0.1	1.0
Commuting to job workplace: Car/motor vehicle	0.4	0.5	0.9	-0.9	0.2
Medication: Aspirin	0.4	0.6	1.1	-1.1	-0.2
Hypertension (Self-reported)	0.4	1.1	2.2	0.2	-1.5
Eye problems/disorders: Glaucoma	0.4	0.4	0.8	0.9	-0.2
Ever smoked	0.4	0.7	1.3	0.1	-1.2
Heart attack/myocardial infarction (self-reported)	0.4	0.5	0.8	-0.4	-0.9
Leg fat mass (left)	0.4	1.4	2.2	-0.8	1.5
Rheumatoid Arthritis	0.3	0.4	0.8	-0.2	0.9
Blood Eosinophil Count	0.3	2.0	2.2	1.5	1.4
Heel T-Score	0.3	2.6	3.5	-1.9	-1.3
Hypothyroidism (self reported)	0.3	0.7	1.3	-1.1	-0.4
Type 2 Diabetes (T2D) (2018)	0.3	0.5	0.8	0.4	-0.9
Lung FEV1/FVC ratio	0.3	1.5	3.0	-1.7	0.3
Number of treatments/medications taken	0.3	0.5	0.9	-0.9	0.2
Average weekly spirits intake	0.3	0.4	0.8	0.9	-0.1
High blood pressure	0.3	1.0	1.7	0.5	-1.3
Forced vital capacity (FVC)	0.3	1.2	1.8	-1.4	0.8
Trunk fat-free mass	0.3	1.5	2.9	0.2	1.7
Impedance of arm (left)	0.3	1.4	1.9	-1.0	-1.4
Trunk predicted mass	0.3	1.5	3.0	0.3	1.7
Glaucoma (self-reported)	0.3	0.4	0.5	0.5	-0.7
Medication: Amlodipine	0.3	0.4	0.8	0.1	-0.9
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.8	0.9	-0.1
Exposure to tobacco smoke outside home	0.3	0.5	0.6	-0.8	-0.6
Wheeze or whistling in the chest in last year	0.3	0.5	0.9	-0.0	-1.0
Shortness of breath walking on level ground	0.3	0.4	0.4	-0.6	0.6
Qualifications: College or University degree	0.3	0.8	0.9	1.0	0.8
Leg fat mass (right)	0.3	1.2	1.8	-0.7	1.3
Diabetes diagnosed by doctor	0.3	0.6	0.9	0.4	-1.0
Osteoarthritis (self-reported)	0.3	0.4	0.7	-0.4	0.8
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.7	0.3	-0.8
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.7	-0.9	-0.2
High cholesterol (Self-reported)	0.3	0.5	0.7	0.8	-0.6
Medication: Lisinopril	0.3	0.4	0.6	0.5	0.7
Arm fat-free mass (left)	0.3	1.6	3.0	0.5	1.7
Arm predicted mass (left)	0.3	1.4	2.8	0.2	1.7
Major Depression (MDD)	0.2	0.3	0.5	-0.1	-0.7
Verbal and Numeric Reasoning (VNR)	0.2	0.6	0.9	0.9	0.5
Bipolar Disorder (2011)	0.2	0.2	0.3	-0.2	-0.6
HbA1C	0.2	0.2	0.3	0.6	0.2
Triglycerides	0.2	0.4	0.8	-0.0	-0.9
Neuroticism	0.2	0.5	0.8	-0.9	-0.4
Supplements: Zinc	0.2	0.2	0.3	0.5	0.2
Medication: Metformin	0.2	0.2	0.5	0.7	-0.1
Diabetes (father)	0.2	0.3	0.6	0.0	-0.8
Maternal smoking around birth	0.2	0.3	0.5	-0.1	-0.7
Diabetes (self-reported)	0.2	0.2	0.2	0.5	-0.5
Illnesses of siblings	0.2	0.3	0.3	-0.5	-0.6
Neuroticism score	0.2	0.5	0.7	-0.9	-0.5
Hip circumference	0.2	1.0	1.9	-0.2	1.4
Number of live births	0.2	0.2	0.4	-0.7	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.5	0.7	-0.6	0.8
Standing height	0.2	1.6	2.5	-0.8	-1.6
Hair/balding pattern: Pattern 4	0.2	0.6	1.2	0.0	1.1
Health satisfaction	0.2	0.3	0.5	0.7	0.2
Medication: Omeprazole	0.2	0.2	0.3	-0.6	0.4
Suffer from ‘nerves’	0.2	0.4	0.4	-0.6	0.6
Overall health rating	0.2	0.5	0.8	-0.5	0.9
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.5	-0.7	-0.4
Commuting to job workplace: Walk	0.2	0.2	0.4	-0.6	0.3
Medication: Bendroflumethiazide	0.2	0.3	0.5	-0.2	-0.7
Alcohol drinker status: Never	0.2	0.3	0.4	0.4	-0.6
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.3	-0.6	0.4
Alzheimer’s Disease (including proxy)	0.1	0.2	0.3	0.3	-0.5
Blood Platelet Count	0.1	1.1	2.0	-0.3	-1.4
Blood Red Count	0.1	1.4	2.5	-0.5	-1.6
Blood White Count	0.1	1.1	2.1	0.2	-1.4
Height	0.1	1.6	2.1	-1.1	-1.4
Vitamin and mineral supplements	0.1	0.2	0.3	0.5	-0.2
Hand grip strength (right)	0.1	0.3	0.3	-0.5	-0.5
Average weekly fortified wine intake	0.1	0.1	0.2	-0.0	-0.5
Age when periods started (menarche)	0.1	0.3	0.3	-0.5	-0.6
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.2	0.2	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.5	-0.3	-0.7
Multivitamins +/- minerals	0.1	0.1	0.1	-0.1	-0.3
Medication: Levothyroxine sodium	0.1	0.1	0.2	-0.3	0.4
Sitting height	0.1	0.7	1.0	0.6	-1.0
Waist circumference	0.1	0.4	0.6	-0.5	0.8
Fluid intelligence score	0.1	0.2	0.4	-0.1	-0.6
Impedance of arm (right)	0.1	0.6	0.8	-0.9	-0.6
Hair/balding pattern: Pattern 3	0.1	0.2	0.3	-0.2	0.5
Length of working week for main job	0.1	0.1	0.2	-0.0	0.4
Breastfed as a baby	0.1	0.2	0.3	-0.0	-0.6
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.5	-0.1	0.7
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.1	0.3	-0.2
Forced vital capacity (FVC), Best measure	0.1	0.5	0.6	-0.6	0.8
Leg fat percentage (right)	0.1	0.2	0.4	-0.6	0.3
Arm fat-free mass (right)	0.1	0.3	0.6	-0.2	0.8
Arm predicted mass (right)	0.1	0.3	0.6	0.1	0.7
Knee pain experienced in last month	0.1	0.1	0.3	-0.2	0.5
Ever had bowel cancer screening	0.1	0.1	0.1	0.1	-0.4
Osteoporosis (self-reported)	0.1	0.2	0.2	0.4	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.3	-0.3	0.5
Average weekly champagne plus white wine intake	0.1	0.2	0.3	-0.2	0.5
Leg fat percentage (left)	0.1	0.4	0.6	-0.8	0.4
Ever had prostate specific antigen (PSA) test	0.1	0.2	0.2	0.4	0.4
Unable to work because of sickness or disability	0.1	0.2	0.2	-0.5	-0.3
Intelligence (Savage-Jansen 2018)	0.0	0.0	0.0	-0.2	0.1
Taking other prescription medications	0.0	0.0	0.0	-0.1	0.2
Serious illness, injury or assault to yourself	0.0	0.0	0.1	0.3	0.1
Stomach or abdominal pain in last month	0.0	0.0	0.0	-0.2	-0.2
Supplements: Glucosamine	0.0	0.1	0.1	0.1	0.3
Medication: Atenolol	0.0	0.0	0.0	-0.0	-0.1
Hearing difficulty/problems with background noise	0.0	0.0	0.1	0.0	0.3
Medication: Simvastatin	0.0	0.1	0.1	0.4	0.0
Qualifications: O levels/GCSEs or equivalent	0.0	0.0	0.0	-0.1	-0.2
Medication: Allopurinol	0.0	0.0	0.1	-0.0	-0.3
Pulse rate, automated reading	0.0	0.1	0.2	0.1	0.4
Comparative height size at age 10	0.0	0.1	0.3	-0.5	-0.1
Illnesses of siblings: Diabetes	0.0	0.1	0.1	0.3	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.0	0.0	0.1	0.2	-0.2
Handedness (chirality/laterality): Left-handed	0.0	0.0	0.1	0.1	0.3
Mood swings	0.0	0.0	0.1	-0.1	-0.2
Qualifications: nursing, teaching	0.0	0.0	0.1	-0.2	0.1
Wears glasses or contact lenses	0.0	0.0	0.1	0.1	0.2
Supplements: Calcium	0.0	0.0	0.0	-0.1	-0.1

Hub : Genes

SYT11

Models

Trait associations