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chr19:17,695,449-20,451,172

Best TWAS P=1.01e-16 · Best GWAS P=9.62e-20 conditioned to 1.86e-06

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	GATAD2A	0.13	0.30	lasso	7	0.29	2.4e-35	7.19	-7.1	1.5e-12	0.01	0.05	0.95	FALSE
2	CommonMind	Brain Pre-frontal Cortex	HAPLN4	0.07	0.10	lasso	6	0.10	5.3e-12	5.26	5.8	7.7e-09	-0.01	0.99	0.01	FALSE
3	CommonMind	Brain Pre-frontal Cortex	MAU2	0.09	0.08	blup	369	0.10	1.0e-12	6.34	-6.5	1.1e-10	0.02	0.31	0.69	FALSE
4	GTEx	Artery Tibial	MAU2	0.07	0.05	lasso	4	0.05	1.3e-04	6.59	5.3	1.4e-07	0.01	0.08	0.86	FALSE
5	GTEx	Brain Cerebellum	SUGP2	0.15	-0.01	enet	27	0.00	2.3e-01	5.32	5.6	2.2e-08	-0.02	0.03	0.64	FALSE
6	GTEx	Brain Cerebellum	ARMC6	0.28	0.00	enet	43	0.13	1.5e-04	-0.69	5.8	7.5e-09	0.00	0.04	0.65	FALSE
7	GTEx	Brain Cerebellum	PBX4	0.20	0.09	lasso	6	0.13	9.9e-05	7.54	6.5	6.0e-11	-0.04	0.02	0.94	FALSE
8	GTEx	Cells Transformed fibroblasts	LPAR2	0.04	0.05	lasso	2	0.04	5.5e-04	6.49	-7.2	5.9e-13	0.04	0.01	0.97	FALSE
9	GTEx	Cells Transformed fibroblasts	GATAD2A	0.07	0.00	lasso	4	0.00	8.1e-01	7.11	5.8	7.3e-09	0.00	0.06	0.42	FALSE
10	GTEx	Colon Transverse	YJEFN3	0.09	0.09	lasso	3	0.07	4.3e-04	5.95	-6.2	5.8e-10	0.01	0.34	0.19	FALSE
11	GTEx	Lung	LPAR2	0.07	0.09	lasso	3	0.05	9.9e-05	6.49	-6.4	1.5e-10	0.05	0.05	0.95	FALSE
12	GTEx	Muscle Skeletal	SUGP1	0.11	0.06	lasso	7	0.07	9.5e-08	5.26	-6.4	1.3e-10	0.01	0.73	0.27	FALSE
13	GTEx	Muscle Skeletal	MAU2	0.09	0.04	lasso	4	0.05	5.1e-06	2.75	-5.3	1.2e-07	0.04	0.15	0.85	FALSE
14	GTEx	Nerve Tibial	LPAR2	0.14	0.05	lasso	5	0.06	2.3e-05	6.49	-6.7	2.6e-11	0.06	0.06	0.91	FALSE
15	GTEx	Nerve Tibial	GMIP	0.19	0.09	lasso	6	0.03	3.9e-03	5.27	-5.5	2.8e-08	0.06	0.46	0.39	FALSE
16	GTEx	Spleen	LPAR2	0.27	0.06	lasso	6	0.04	2.7e-02	4.60	-6.5	6.9e-11	0.04	0.09	0.32	FALSE
17	GTEx	Spleen	ATP13A1	0.16	0.01	lasso	5	0.02	9.7e-02	7.12	6.2	5.1e-10	-0.02	0.03	0.61	FALSE
18	GTEx	Thyroid	YJEFN3	0.05	0.02	lasso	3	0.02	1.2e-02	5.43	-5.9	3.4e-09	0.02	0.08	0.67	FALSE
19	GTEx	Vagina	LRRC25	0.63	0.02	enet	2	0.04	5.3e-02	-7.62	7.6	2.1e-14	0.54	0.05	0.09	TRUE
20	GTEx	Whole Blood	TMEM161A	0.06	0.00	enet	2	0.00	1.4e-01	7.11	-7.1	1.1e-12	0.01	0.06	0.74	FALSE
21	GTEx	Whole Blood	LPAR2	0.10	0.07	lasso	5	0.07	8.0e-07	6.49	-5.7	1.1e-08	0.05	0.83	0.15	FALSE
22	GTEx	Whole Blood	GATAD2A	0.06	0.02	lasso	9	0.03	1.7e-03	6.51	5.7	1.2e-08	-0.02	0.10	0.86	FALSE
23	NTR	Blood	ATP13A1	0.01	0.01	blup	339	0.01	1.9e-04	-0.84	5.2	2.2e-07	0.02	0.07	0.29	FALSE
24	NTR	Blood	GATAD2A	0.02	0.02	blup	386	0.02	1.4e-07	6.59	6.3	2.6e-10	0.01	0.07	0.93	FALSE
25	ROSMAP	Brain Pre-frontal Cortex	JUND	0.17	0.17	lasso	5	0.20	2.7e-25	-7.62	-5.2	2.0e-07	-0.22	1.00	0.00	FALSE
26	ROSMAP	Brain Pre-frontal Cortex	TSSK6	0.04	0.00	blup	346	0.01	1.1e-02	5.47	5.9	3.9e-09	-0.02	0.30	0.21	FALSE
27	ROSMAP	Brain Pre-frontal Cortex	HAPLN4	0.05	0.03	enet	15	0.03	1.7e-04	5.32	5.2	1.7e-07	-0.08	0.44	0.55	FALSE
28	YFS	Blood	GATAD2A	0.09	0.14	blup	365	0.14	7.5e-44	7.12	7.0	1.8e-12	-0.01	0.05	0.95	FALSE
29	YFS	Blood	LPAR2	0.14	0.15	lasso	5	0.16	3.6e-48	6.58	-6.6	3.9e-11	0.04	0.67	0.33	FALSE
30	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	YJEFN3	0.04	0.05	lasso	7	0.04	1.6e-04	5.78	-6.9	6.5e-12	0.01	0.06	0.81	FALSE
31	The Cancer Genome Atlas	Breast Invasive Carcinoma	CILP2	0.02	0.02	blup	30	0.02	1.6e-04	5.82	6.4	1.2e-10	0.00	0.15	0.27	FALSE
32	The Cancer Genome Atlas	Breast Invasive Carcinoma	HAPLN4	0.04	0.07	lasso	4	0.06	1.3e-12	5.10	5.8	6.7e-09	0.00	0.76	0.24	FALSE
33	The Cancer Genome Atlas	Colon Adenocarcinoma	GATAD2A	0.04	0.03	blup	61	0.05	1.3e-03	7.10	7.0	2.2e-12	-0.02	0.03	0.84	FALSE
34	The Cancer Genome Atlas	Colon Adenocarcinoma	HAPLN4	0.10	0.08	blup	38	0.11	8.5e-07	6.30	6.0	2.1e-09	-0.01	0.01	0.99	FALSE
35	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	GATAD2A	0.02	0.02	lasso	1	0.02	2.1e-03	7.13	7.1	9.7e-13	-0.01	0.02	0.80	FALSE
36	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	HAPLN4	0.07	0.05	lasso	7	0.07	2.9e-08	5.20	6.1	8.1e-10	-0.01	0.04	0.96	FALSE
37	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GMIP	0.03	0.02	lasso	4	0.02	3.2e-03	6.49	7.4	1.8e-13	-0.03	0.00	0.94	TRUE
38	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	HAPLN4	0.05	0.07	lasso	2	0.06	1.1e-07	6.17	5.9	3.5e-09	-0.02	0.01	0.99	FALSE
39	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	JUND	0.05	0.04	lasso	1	0.04	4.3e-05	-7.62	-7.6	2.6e-14	-0.53	0.14	0.13	FALSE
40	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SF4	0.03	0.01	enet	7	0.02	1.1e-03	6.47	5.4	5.4e-08	-0.03	0.02	0.94	FALSE
41	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	GMIP	0.07	0.02	enet	6	0.04	1.9e-03	1.74	5.2	2.1e-07	-0.01	0.03	0.32	FALSE
42	The Cancer Genome Atlas	Brain Lower Grade Glioma	GMIP	0.07	0.04	blup	43	0.04	8.5e-06	5.33	6.6	5.1e-11	-0.03	0.05	0.94	FALSE
43	The Cancer Genome Atlas	Brain Lower Grade Glioma	JUND	0.04	0.03	lasso	2	0.02	7.9e-04	-7.62	-7.5	6.4e-14	-0.52	0.18	0.10	FALSE
44	The Cancer Genome Atlas	Brain Lower Grade Glioma	KIAA0892	0.03	0.01	lasso	7	0.02	6.3e-03	6.18	-6.4	1.6e-10	0.01	0.03	0.63	FALSE
45	The Cancer Genome Atlas	Brain Lower Grade Glioma	MAST3	0.02	0.02	lasso	3	0.01	1.5e-02	-7.86	8.2	1.8e-16	0.31	0.01	0.93	FALSE
46	The Cancer Genome Atlas	Brain Lower Grade Glioma	TSSK6	0.02	0.02	blup	33	0.02	1.8e-03	7.10	7.2	4.4e-13	-0.01	0.01	0.83	FALSE
47	The Cancer Genome Atlas	Prostate Adenocarcinoma	GATAD2A	0.04	0.03	lasso	2	0.03	2.9e-04	7.17	6.4	1.4e-10	-0.01	0.02	0.95	FALSE
48	The Cancer Genome Atlas	Prostate Adenocarcinoma	YJEFN3	0.04	0.05	lasso	2	0.05	4.3e-06	5.85	-5.8	5.1e-09	0.00	0.54	0.32	FALSE
49	The Cancer Genome Atlas	Soft Tissue Sarcoma	HAPLN4	0.11	0.01	blup	38	0.02	2.7e-02	5.20	6.1	1.3e-09	0.00	0.02	0.67	FALSE
50	The Cancer Genome Atlas	Thyroid Carcinoma	HAPLN4	0.08	0.06	blup	37	0.09	1.8e-09	6.38	6.2	7.0e-10	0.00	0.01	0.99	FALSE
51	The Cancer Genome Atlas	Thyroid Carcinoma	KIAA0892	0.04	0.04	blup	43	0.02	4.1e-03	6.19	-6.5	8.3e-11	0.02	0.05	0.91	FALSE
52	The Cancer Genome Atlas	Thyroid Carcinoma	MAST3	0.04	0.02	lasso	2	0.00	3.4e-01	-7.86	8.3	1.0e-16	0.32	0.01	0.92	TRUE