TWAS hub - MAPRE1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.1080	0.0380	1.0e-03	0.081	NA	0.025	NA	0.056	1.1e-06	NA	5.5e-03	NA	4.9e-05
2	GTEx	Esophagus Mucosa	0.1810	0.0450	1.9e-09	0.226	NA	0.229	NA	0.221	4.0e-15	NA	2.3e-15	NA	8.2e-15
3	GTEx	Lung	0.1067	0.0454	2.8e-03	0.010	NA	0.005	NA	0.013	5.1e-02	NA	1.2e-01	NA	3.1e-02
4	GTEx	Nerve Tibial	0.1199	0.0380	2.4e-04	0.106	NA	0.093	NA	0.104	6.5e-08	NA	3.9e-07	NA	9.0e-08
5	GTEx	Skin Not Sun Exposed Suprapubic	0.3790	0.0680	1.1e-13	0.235	NA	0.290	NA	0.273	4.2e-13	NA	2.8e-16	NA	2.8e-15
6	GTEx	Skin Sun Exposed Lower leg	0.3080	0.0560	4.7e-15	0.206	NA	0.240	NA	0.234	6.1e-17	NA	9.2e-20	NA	2.7e-19
7	GTEx	Whole Blood	0.1140	0.0370	7.8e-06	0.054	NA	0.053	NA	0.044	1.0e-05	NA	1.2e-05	NA	6.7e-05
8	METSIM	Adipose	0.0306	0.0140	1.9e-03	0.024	0.011	0.012	0.010	0.016	1.5e-04	6.9e-03	5.0e-03	1.0e-02	1.6e-03
9	YFS	Blood	0.1105	0.0255	0.0e+00	0.096	0.083	0.102	0.099	0.102	9.8e-30	7.2e-26	1.5e-31	1.1e-30	1.8e-31
10	TCGA	Breast Invasive Carcinoma	0.0452	0.0191	1.1e-08	0.025	0.035	0.030	NA	0.030	4.6e-06	7.9e-08	7.8e-07	NA	8.0e-07
11	TCGA	Colon Adenocarcinoma	0.1880	0.1100	1.4e-04	0.048	0.056	0.040	NA	0.054	9.1e-04	3.6e-04	2.4e-03	NA	4.5e-04
12	TCGA	Head and Neck Squamous Cell Carcinoma	0.1370	0.0478	1.3e-07	0.026	0.072	0.057	NA	0.056	5.8e-04	1.8e-08	5.0e-07	NA	5.9e-07
13	TCGA	Lung Squamous Cell Carcinoma	0.0205	0.0135	9.0e-03	0.016	0.019	0.005	NA	0.011	5.9e-03	2.4e-03	8.8e-02	NA	1.6e-02
14	TCGA	Ovarian Serous Cystadenocarcinoma	0.0360	0.0200	3.9e-03	0.031	0.027	0.001	NA	0.015	3.3e-03	5.6e-03	2.4e-01	NA	3.2e-02
15	TCGA	Prostate Adenocarcinoma	0.0715	0.0296	2.9e-07	0.068	0.081	0.072	NA	0.069	1.1e-07	7.3e-09	5.1e-08	NA	1.1e-07
16	TCGA	Rectum Adenocarcinoma	0.4810	0.1360	7.1e-04	0.047	0.046	0.053	NA	0.087	2.9e-02	3.1e-02	2.3e-02	NA	4.5e-03
17	TCGA	Thyroid Carcinoma	0.0500	0.0250	3.5e-04	0.067	0.036	0.052	NA	0.059	4.5e-07	2.0e-04	8.0e-06	NA	2.0e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17
Hair/balding pattern: Pattern 4	8.3	20.2	29.1	-4.0	-5.1	-5.4	-4.6	-5.1	-4.7	-5.0	2.0	-4.4	-4.7	-4.8	-3.0	-5.1	-5.4	-5.1	-1.9	-4.0
Hair/balding pattern: Pattern 2	7.5	9.5	15.6	-2.6	-3.5	-3.3	-2.9	-3.6	-2.6	-2.6	1.2	-2.9	-3.7	-3.5	-3.1	-3.6	-4.0	-3.4	-2.3	-2.7
Noisy workplace	7.5	9.2	15.8	1.6	3.9	3.8	2.2	4.0	3.4	3.1	-3.0	2.8	2.8	3.3	1.6	3.3	3.3	3.2	3.1	1.7
Serious illness, injury or assault to yourself	6.8	8.3	12.9	3.1	2.8	3.0	3.2	3.0	2.5	2.3	-0.3	3.2	2.8	3.4	2.4	3.6	3.5	3.2	2.0	3.0
Medication: Omeprazole (e.g. Zanprol)	6.1	7.5	13.8	2.6	3.0	2.9	2.8	3.1	3.0	2.3	-0.6	2.9	2.0	3.7	2.9	2.7	2.5	3.1	2.4	2.9
Hand grip strength (right)	6.0	16.2	22.9	-2.9	-4.8	-4.7	-3.5	-4.6	-4.8	-4.4	2.5	-3.5	-4.5	-4.7	-3.9	-3.9	-4.3	-4.6	-2.4	-3.2
Medication: Paracetamol	5.9	9.2	14.9	1.7	3.8	3.7	2.3	3.8	2.1	3.5	-2.7	2.5	3.9	2.8	2.5	3.3	3.6	3.5	2.5	1.7
Number of treatments/medications taken	5.1	9.2	23.5	2.7	3.4	2.7	3.0	3.9	1.8	3.0	-1.6	3.8	2.8	3.0	1.1	4.8	3.9	2.8	2.0	2.8
Medication for pain relief, constipation, heartburn	5.1	8.8	14.8	-2.6	-3.4	-3.4	-3.0	-3.5	-2.0	-3.4	1.3	-3.0	-3.3	-2.5	-2.0	-3.7	-3.9	-3.4	-1.9	-2.7
Mean time to correctly identify matches	4.9	9.3	18.3	-3.8	-2.7	-2.9	-3.9	-3.2	-2.2	-2.7	-0.6	-4.3	-2.4	-2.5	-1.3	-4.2	-3.8	-3.0	-1.6	-3.8
Hearing aid user	4.7	5.3	8.7	2.1	2.4	2.4	2.3	2.6	2.4	2.5	-0.8	2.7	1.9	2.8	1.4	2.9	2.9	2.4	0.9	2.1
Medication: Lansoprazole	4.6	5.3	8.1	2.9	2.2	2.7	2.9	2.1	2.1	1.3	0.5	2.4	2.1	2.2	2.7	1.9	1.8	2.7	2.4	2.8
Comparative height size at age 10	4.6	25.3	36.4	-5.4	-5.2	-5.3	-5.8	-5.7	-5.2	-4.2	1.1	-6.0	-5.2	-5.0	-4.2	-6.0	-5.5	-5.7	-0.8	-5.3
Medication: Paracetamol	4.5	7.5	12.9	1.5	3.4	3.2	2.0	3.5	2.0	3.5	-2.6	2.0	3.6	2.4	2.2	3.0	3.3	3.3	2.1	1.4
Pulse wave peak to peak time	4.3	5.0	8.7	-2.3	-2.5	-2.1	-2.5	-2.7	-1.4	-2.5	0.5	-2.4	-2.2	-2.1	-1.7	-2.9	-2.9	-2.3	-1.6	-2.3
Medication: Omeprazole	4.3	5.1	10.5	2.0	2.5	2.4	2.1	2.5	2.7	2.3	-0.8	2.1	1.5	3.2	2.5	1.9	1.8	2.5	2.3	2.1
Unable to work because of sickness or disability	4.3	5.5	10.3	2.3	2.5	2.5	2.6	2.5	1.1	2.1	-0.6	2.3	2.9	2.6	1.9	3.1	3.2	2.8	0.8	2.2
Basal cell carcinoma (self-reported)	4.3	5.1	8.1	1.0	2.8	2.6	1.6	2.7	2.2	2.8	-2.7	1.8	2.1	2.8	0.8	2.2	2.7	2.7	2.2	0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	4.2	5.4	10.4	1.5	2.6	2.0	1.9	2.6	2.4	2.9	-1.4	2.1	3.1	2.7	1.2	3.2	2.9	2.4	1.6	1.6
Shortness of breath walking on level ground	4.2	5.1	9.5	0.9	2.8	2.2	1.3	2.7	2.4	2.6	-2.2	1.6	2.6	3.1	1.9	2.3	2.4	2.4	2.3	1.0
Reaction Time	4.1	7.8	18.2	-3.6	-2.3	-2.5	-3.7	-2.9	-1.7	-2.2	-0.8	-4.2	-2.3	-1.9	-1.0	-4.3	-3.5	-2.5	-0.8	-3.6
Hand grip strength (left)	4.0	10.6	15.6	-2.8	-3.8	-3.4	-3.0	-3.7	-3.7	-3.5	1.5	-3.2	-4.0	-3.7	-3.5	-3.5	-3.3	-3.4	-0.9	-2.9
Ever had prostate specific antigen (PSA) test	4.0	4.7	7.9	-2.5	-2.2	-2.4	-2.4	-2.2	-1.7	-1.9	-0.4	-2.5	-2.5	-1.9	-2.8	-2.1	-1.9	-2.2	-0.8	-2.7
Verbal and Numeric Reasoning (VNR)	3.9	9.3	17.7	-2.3	-3.6	-4.2	-2.8	-3.4	-2.7	-2.9	1.4	-2.5	-3.6	-2.5	-2.7	-3.0	-3.9	-3.8	-2.7	-2.5
Neck or shoulder pain in last month	3.7	5.2	12.1	1.1	2.8	1.7	1.5	3.0	2.1	2.9	-2.2	2.0	2.9	2.1	1.1	3.5	3.2	2.1	1.0	1.2
Pain experienced in last month	3.7	6.2	13.2	-1.7	-2.9	-1.9	-2.0	-3.2	-2.3	-2.6	2.0	-2.5	-3.1	-2.6	-1.8	-3.6	-3.3	-2.7	-0.6	-1.6
Past tobacco smoking	3.6	6.7	15.7	-1.7	-3.1	-2.3	-1.9	-3.5	-2.8	-2.6	2.4	-2.9	-2.5	-2.8	-1.1	-4.0	-2.9	-2.2	-2.0	-1.7
Medication: Ibuprofen	3.5	4.1	7.1	1.7	2.5	2.2	1.9	2.3	1.1	2.3	-1.3	1.6	2.4	1.7	2.1	2.0	2.7	2.5	1.8	1.7
Medication: Ibuprofen (e.g. Nurofen)	3.4	4.3	9.0	1.5	2.5	2.1	1.7	2.4	0.9	2.5	-1.6	1.5	2.4	2.2	1.9	2.3	3.0	2.5	1.6	1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.4	4.0	7.6	1.0	2.5	1.9	1.3	2.5	2.4	1.9	-1.7	1.3	1.9	2.8	2.3	1.7	1.9	2.2	2.5	1.1
Ever smoked	3.3	5.9	11.8	0.8	3.1	2.0	1.2	3.3	3.0	2.6	-3.1	2.0	2.4	2.6	0.9	3.4	2.7	2.1	2.5	0.8
Bipolar Disorder (2011)	3.2	3.1	5.9	-2.0	-1.7	-2.4	-2.1	-1.6	-2.0	-1.6	0.3	-1.7	-1.0	-1.6	-1.4	-1.1	-1.6	-2.4	-2.4	-1.9
Falls in the last year	3.2	4.3	13.1	1.0	2.4	1.9	1.3	2.4	0.6	2.2	-1.7	1.4	2.7	3.0	1.1	3.1	3.6	1.9	0.9	1.0
Leg pain on walking	3.1	3.9	6.1	1.7	2.1	2.0	1.9	2.3	2.5	2.0	-0.9	2.1	1.6	2.2	1.4	2.4	2.2	2.1	1.6	1.7
Hearing difficulty/problems: Yes	3.0	4.5	8.4	2.2	2.1	2.9	2.7	2.4	1.6	2.6	-0.5	2.6	1.8	0.9	0.4	2.3	2.6	2.8	0.9	2.1
Birth weight	3.0	6.5	23.1	-4.6	-0.3	-2.6	-4.1	-0.4	-0.6	-0.3	-4.4	-3.9	-0.2	0.6	-1.7	-0.3	0.1	-1.8	1.0	-4.8
Leg fat-free mass (right)	3.0	15.9	24.8	-2.7	-4.8	-5.0	-3.5	-5.0	-4.9	-4.3	2.8	-3.8	-4.0	-4.3	-2.9	-4.2	-4.4	-4.6	-1.7	-3.0
Leg predicted mass (right)	3.0	16.0	25.1	-2.8	-4.8	-5.0	-3.5	-5.0	-4.9	-4.3	2.8	-3.8	-4.1	-4.3	-3.0	-4.2	-4.5	-4.6	-1.7	-3.0
Hypothyroidism (self reported)	2.9	6.6	12.2	-1.5	-3.0	-3.2	-1.9	-3.0	-1.9	-3.1	1.9	-2.0	-2.8	-3.5	-2.7	-2.6	-3.3	-3.0	-1.3	-1.6
Impedance of leg (right)	2.9	13.8	27.6	0.9	4.7	4.0	1.8	4.8	3.6	4.7	-4.3	2.4	3.8	4.5	1.4	4.7	5.3	3.8	2.9	1.1
Hair/balding pattern: Pattern 3	2.9	4.3	10.2	2.3	2.0	2.6	2.5	2.2	1.3	1.4	-0.1	2.0	2.1	1.9	1.2	2.5	3.2	2.8	0.7	2.1
Pulse wave Arterial Stiffness index	2.9	3.4	6.8	1.7	2.1	1.6	1.9	2.2	1.0	2.2	-0.5	1.9	1.8	1.8	1.2	2.6	2.5	1.8	1.5	1.8
Standing height	2.9	29.1	54.5	-7.3	-4.9	-6.2	-7.4	-5.3	-5.6	-3.3	-1.2	-7.2	-4.8	-4.2	-5.7	-4.6	-3.9	-6.0	-0.4	-7.4
Intelligence (Savage-Jansen 2018)	2.8	8.6	14.4	-1.9	-3.5	-3.7	-2.4	-3.5	-2.4	-3.0	2.2	-2.6	-3.2	-2.9	-1.9	-3.5	-3.8	-3.5	-2.4	-2.1
LDL Cholesterol	2.8	4.4	7.5	0.8	2.5	2.3	1.2	2.5	2.5	2.4	-2.3	1.5	2.6	1.8	1.2	2.1	2.3	2.7	2.3	0.8
Trunk predicted mass	2.8	15.9	27.5	-3.5	-4.5	-5.2	-4.0	-4.6	-5.2	-4.1	1.8	-4.0	-4.1	-3.9	-3.6	-3.5	-3.8	-4.7	-1.5	-3.7
Leg fat-free mass (left)	2.7	14.3	23.2	-2.6	-4.6	-4.7	-3.3	-4.7	-4.8	-4.2	2.6	-3.6	-3.9	-3.9	-2.7	-4.0	-4.2	-4.3	-1.6	-2.9
Taking other prescription medications	2.7	4.1	9.1	2.3	2.0	1.6	2.4	2.4	1.3	1.8	-0.4	2.8	1.5	2.1	1.3	3.0	2.0	1.9	1.8	2.3
Multivitamins +/- minerals	2.7	3.5	8.4	-2.7	-1.2	-2.3	-2.9	-1.4	-1.6	-1.2	-1.1	-2.8	-0.9	-0.7	0.0	-1.9	-1.9	-2.1	-0.9	-2.8
Chronic bronchitis/emphysema (father)	2.7	3.2	7.0	1.6	1.9	1.7	1.7	2.1	2.1	1.7	-0.6	1.9	2.6	1.3	1.1	2.4	2.2	1.9	0.1	1.5
Leg predicted mass (left)	2.7	14.3	23.1	-2.6	-4.6	-4.7	-3.3	-4.7	-4.8	-4.2	2.6	-3.6	-3.9	-3.9	-2.7	-4.0	-4.2	-4.3	-1.6	-2.9
Trunk fat-free mass	2.7	15.7	27.1	-3.5	-4.5	-5.2	-4.0	-4.6	-5.1	-4.1	1.7	-4.0	-4.0	-3.9	-3.6	-3.5	-3.8	-4.7	-1.5	-3.7
Diabetes (father)	2.6	3.2	4.8	2.0	1.7	2.0	2.2	1.6	1.6	1.8	-0.0	1.9	1.7	1.8	1.8	1.5	1.6	1.9	1.8	2.2
Qualifications: CSEs or equivalent	2.6	3.5	8.1	0.1	2.3	1.5	0.4	2.4	1.2	2.3	-2.9	1.0	2.1	2.3	0.7	2.6	2.7	1.7	1.6	0.2
Exposure to tobacco smoke at home	2.6	3.0	5.3	1.9	1.7	1.8	1.9	1.8	2.3	2.0	-0.3	2.0	1.7	1.5	1.8	1.7	1.4	1.8	0.4	1.9
Health satisfaction	2.6	3.4	7.6	1.5	2.0	1.4	1.6	2.2	1.9	1.5	-0.9	2.0	1.9	2.4	1.3	2.8	2.2	1.8	1.6	1.5
Smoking status: Previous	2.6	3.9	12.0	1.6	2.2	1.5	1.7	2.7	1.9	1.9	-1.6	2.4	2.0	2.0	0.6	3.5	2.3	1.5	0.7	1.6
Whole body fat-free mass	2.6	15.1	25.5	-3.0	-4.6	-5.0	-3.6	-4.7	-5.0	-4.2	2.3	-3.7	-4.0	-4.0	-3.3	-3.6	-3.9	-4.5	-1.6	-3.2
Long-standing illness, disability or infirmity	2.6	4.0	9.0	2.1	2.1	1.5	2.2	2.4	0.9	2.3	-0.5	2.4	1.9	1.9	1.2	3.0	2.5	1.9	1.4	2.1
Whole body water mass	2.6	15.0	26.2	-2.9	-4.6	-5.1	-3.5	-4.6	-5.1	-4.2	2.4	-3.7	-4.0	-4.0	-3.4	-3.5	-3.8	-4.5	-1.7	-3.2
Other serious medical condition/disability diagnosed by doctor	2.5	3.3	10.4	1.1	1.9	1.3	1.5	2.2	0.8	2.3	-1.0	1.7	1.8	1.9	0.1	3.2	3.1	1.7	0.7	1.2
Alcohol usually taken with meals	2.5	4.0	8.2	-1.8	-2.2	-2.2	-1.9	-2.2	-0.7	-1.6	0.5	-1.8	-2.3	-2.1	-2.4	-2.2	-2.9	-2.3	-1.5	-1.9
Average weekly champagne plus white wine intake	2.5	3.4	10.4	-1.5	-1.9	-1.9	-1.7	-1.9	-0.7	-1.4	0.9	-1.5	-2.4	-2.2	-1.3	-2.4	-3.2	-2.3	-0.0	-1.3
Prostate Cancer	2.4	3.4	10.0	-1.4	-2.2	-1.1	-1.6	-2.4	-0.6	-2.1	1.5	-2.4	-2.1	-1.9	-1.0	-3.2	-2.3	-1.4	0.1	-1.6
Height	2.4	46.7	81.5	-8.7	-6.5	-7.9	-8.9	-6.9	-7.0	-4.8	-0.9	-9.0	-6.1	-6.3	-7.3	-6.1	-5.2	-7.6	-0.8	-9.0
Smoking Status	2.4	5.9	12.2	1.1	3.0	2.3	1.5	3.3	2.5	2.2	-2.7	2.6	2.7	2.0	0.8	3.5	2.7	2.3	2.8	1.1
Impedance of leg (left)	2.4	11.8	24.9	0.9	4.3	3.6	1.8	4.5	3.4	4.5	-3.7	2.2	3.6	3.9	1.0	4.5	5.0	3.6	2.6	1.2
Forced vital capacity (FVC)	2.4	9.4	17.4	-4.2	-2.8	-3.5	-4.1	-3.1	-2.3	-1.7	-0.7	-4.0	-2.6	-2.7	-3.1	-3.2	-3.0	-3.3	-0.1	-4.1
Forced expiratory volume in 1-second (FEV1), predicted	2.4	4.9	14.4	-3.8	-1.2	-2.0	-3.4	-1.4	-2.0	-0.3	-2.1	-3.3	-1.1	-1.2	-2.9	-1.2	-0.3	-1.6	0.7	-3.8
Basal metabolic rate	2.3	12.6	23.8	-2.5	-4.2	-4.6	-3.1	-4.3	-4.9	-3.9	2.4	-3.3	-3.6	-3.7	-3.0	-3.2	-3.5	-4.1	-1.4	-2.7
Pulse rate	2.2	3.7	6.9	2.4	1.7	1.8	2.5	2.1	1.5	1.5	0.1	2.6	1.5	2.1	1.3	2.6	2.1	2.1	0.4	2.4
Pack years of smoking	2.2	3.2	6.8	1.2	2.1	1.6	1.3	2.1	1.4	1.9	-1.6	1.4	2.2	1.8	1.4	2.5	2.6	1.7	1.5	1.2
Lung FEV1/FVC ratio	2.1	10.5	27.8	-0.8	3.7	3.9	0.0	3.4	5.1	4.5	-5.3	0.8	1.7	4.3	2.0	1.3	1.6	2.9	4.8	-0.7
Allergy	2.1	4.9	18.1	-1.0	2.8	1.5	-0.3	2.9	2.8	2.6	-4.3	0.7	1.8	3.1	0.5	2.5	2.0	1.6	1.9	-0.8
Friendships satisfaction	2.1	2.6	7.2	-2.4	-1.1	-1.6	-2.5	-1.3	-0.8	-0.2	-1.3	-2.5	-1.0	-0.8	-0.1	-1.9	-1.8	-1.5	0.1	-2.7
Arm fat-free mass (left)	2.1	10.7	23.9	-1.8	-4.0	-4.3	-2.4	-3.9	-4.9	-4.0	2.6	-2.6	-3.2	-3.6	-3.1	-2.5	-2.8	-3.7	-2.1	-2.1
Tinnitus: Yes, but not now, but have in the past	2.0	2.1	3.6	1.3	1.7	1.8	1.5	1.6	0.9	1.5	-0.6	1.1	1.3	1.5	1.8	0.8	1.7	1.9	1.6	1.4
Sitting height	2.0	13.9	23.5	-4.6	-3.6	-4.7	-4.8	-3.8	-4.1	-2.2	-0.2	-4.5	-3.9	-3.0	-3.5	-3.3	-3.4	-4.5	0.6	-4.7
Fluid intelligence score	2.0	4.1	8.5	-1.4	-2.5	-2.9	-1.7	-2.3	-1.9	-1.9	1.2	-1.3	-2.3	-1.8	-1.9	-1.8	-2.6	-2.5	-2.2	-1.5
Forced vital capacity (FVC), Best measure	2.0	7.4	15.3	-3.9	-2.2	-2.8	-3.8	-2.5	-2.0	-1.3	-1.1	-3.7	-2.0	-2.5	-3.0	-2.8	-2.6	-2.7	-0.0	-3.9
Comparative body size at age 10	2.0	5.6	9.9	-1.4	-2.7	-2.5	-1.9	-2.8	-2.8	-2.8	2.0	-1.9	-2.8	-2.8	-1.6	-2.6	-3.1	-2.8	-0.3	-1.5
Number of full brothers	2.0	2.6	5.5	-0.2	1.9	2.0	0.3	1.8	1.2	1.5	-2.1	0.6	2.4	1.7	1.0	1.7	2.4	1.5	2.0	0.0
Overall health rating	2.0	4.4	10.9	1.8	2.3	1.7	2.0	2.6	1.2	2.1	-1.3	2.2	2.0	2.1	0.7	3.3	2.9	2.1	2.0	1.8
Illness, injury, bereavement, stress in last 2 years	2.0	2.5	5.9	-0.7	-1.8	-1.3	-1.0	-1.9	-2.4	-2.0	1.4	-1.6	-1.5	-1.8	-0.8	-2.1	-2.1	-1.4	-0.5	-0.8
Average weekly red wine intake	2.0	2.9	5.9	-2.1	-1.4	-2.1	-2.2	-1.7	-1.5	-0.9	-0.6	-2.4	-1.1	-1.1	0.2	-2.3	-2.0	-1.9	-1.2	-2.1
Wears glasses or contact lenses	2.0	2.3	6.3	0.4	1.9	0.9	0.8	2.0	1.2	1.5	-1.9	1.5	1.4	2.5	0.5	2.3	2.2	1.4	0.4	0.6
Arm predicted mass (left)	2.0	10.1	21.8	-1.8	-3.9	-4.3	-2.4	-3.7	-4.7	-3.8	2.5	-2.5	-3.1	-3.6	-3.2	-2.3	-2.7	-3.7	-1.9	-2.1
Alzheimer’s Disease (including proxy)	1.9	2.8	6.9	-0.4	-2.0	-2.0	-0.9	-1.9	-1.8	-1.6	1.9	-1.2	-1.8	-2.6	-1.9	-1.3	-1.5	-1.9	-1.5	-0.6
Primary Biliary Cirrhosis	1.9	2.6	7.3	0.3	-2.1	-2.4	0.0	-1.8	-2.5	-1.9	2.7	-0.2	-1.6	-1.3	-1.2	-0.3	-0.9	-1.6	-2.1	0.3
Pack years adult smoking proportion	1.9	2.9	5.1	1.0	2.0	1.6	1.2	2.0	1.6	1.9	-1.6	1.2	2.1	1.5	1.6	2.1	2.3	1.7	1.7	1.0
Back pain experienced in last month	1.9	2.8	8.5	1.8	1.7	0.9	1.8	2.0	0.7	1.4	-0.5	2.0	1.8	1.5	1.0	2.9	2.5	1.8	0.1	1.7
Vitamin and mineral supplements	1.8	2.4	5.2	1.9	1.2	2.3	2.1	1.4	1.6	1.5	0.5	1.9	0.8	0.8	0.5	1.4	1.7	1.9	1.4	2.0
Had major operations	1.8	2.1	3.6	-0.4	-1.8	-1.7	-0.7	-1.9	-1.4	-1.7	1.4	-0.9	-1.9	-1.8	-1.3	-1.9	-1.6	-1.5	-0.9	-0.8
Ulcerative Colitis	1.7	2.5	9.4	1.4	1.3	1.1	1.6	1.9	0.8	0.8	-0.2	1.9	1.3	2.0	0.3	3.1	2.7	1.5	-0.2	1.3
Blood Platelet Count	1.7	19.4	34.5	-3.6	-4.9	-5.8	-4.1	-5.0	-5.9	-4.8	2.0	-4.4	-3.3	-4.3	-3.3	-4.2	-4.0	-5.1	-4.7	-3.7
Allergy or Eczema	1.7	4.4	10.2	0.2	-2.6	-1.4	-0.3	-2.8	-2.7	-2.5	3.2	-1.0	-2.2	-3.0	-1.5	-2.6	-2.0	-1.9	-1.9	0.2
Forced expiratory volume in 1-second (FEV1)	1.7	5.7	15.5	-3.9	-1.6	-2.1	-3.7	-1.9	-0.7	-0.3	-1.8	-3.4	-1.8	-1.3	-1.9	-2.6	-2.5	-2.2	1.0	-3.9
Arm fat-free mass (right)	1.7	8.5	18.5	-1.4	-3.6	-4.0	-2.0	-3.5	-4.3	-3.4	2.8	-2.2	-2.7	-3.4	-2.5	-2.1	-2.6	-3.4	-1.9	-1.7
Financial situation satisfaction	1.7	2.2	5.0	0.1	1.8	0.7	0.4	1.8	0.7	2.0	-2.2	0.7	1.6	1.8	1.3	1.4	1.7	1.6	2.0	0.0
Tanning	1.6	20.1	94.9	4.5	-3.8	-4.7	2.6	-2.5	-8.0	-1.8	9.7	2.1	-2.6	-5.3	-2.3	3.8	0.4	-4.1	-3.3	4.8
Ever had hysterectomy (womb removed)	1.6	1.8	5.2	-1.4	-1.3	-1.4	-1.4	-1.4	-1.0	-0.5	-0.0	-1.4	-1.1	-2.3	-2.2	-1.0	-1.0	-1.5	-1.1	-1.3
Qualifications: None of the above	1.6	3.4	5.6	1.0	2.1	2.4	1.4	2.3	1.9	2.2	-1.5	2.0	1.8	2.3	1.5	2.2	2.1	2.0	0.1	1.2
Pain all over the body in last month	1.6	1.7	3.9	0.4	1.6	1.4	0.7	1.5	0.6	1.0	-1.4	0.7	2.0	1.8	1.6	1.4	1.4	1.2	1.7	0.6
Eye problems/disorders: Diabetes related eye disease	1.5	1.6	2.5	1.3	1.3	1.5	1.4	1.3	1.4	0.8	-0.3	1.2	1.4	1.5	1.5	0.9	1.3	1.6	1.1	1.2
Hayfever, allergic rhinitis or eczema	1.5	3.3	11.3	0.7	-2.4	-1.2	0.2	-2.5	-2.3	-2.1	3.4	-0.7	-1.6	-2.5	-0.9	-2.0	-1.4	-1.3	-1.9	0.6
Medication: Atenolol	1.5	1.9	5.8	0.0	1.7	1.6	0.6	1.7	1.2	1.4	-1.8	0.7	1.7	1.2	-0.0	2.1	2.4	1.4	0.9	0.4
Heart attack	1.5	2.0	4.6	1.3	1.6	1.3	1.4	1.6	0.7	1.3	-0.8	1.4	1.4	1.3	0.4	1.9	2.2	1.2	1.5	1.3
Illnesses of siblings	1.5	2.1	5.0	-2.2	-1.1	-1.8	-2.0	-1.3	-0.8	0.1	-0.9	-1.7	-1.2	-0.8	-2.2	-0.8	-0.8	-1.8	-1.0	-2.0
Birth weight of first child	1.5	2.7	15.2	-2.4	1.2	-0.1	-1.6	1.0	1.6	1.5	-3.9	-1.2	1.5	1.9	0.2	0.5	1.0	0.3	1.1	-2.4
Arm predicted mass (right)	1.5	7.5	16.5	-1.1	-3.4	-3.7	-1.8	-3.3	-4.1	-3.3	2.8	-1.9	-2.7	-3.2	-2.3	-2.0	-2.5	-3.2	-1.6	-1.4
Ever had bowel cancer screening	1.5	1.8	5.7	-1.3	-1.3	-1.4	-1.0	-1.2	-2.2	-1.7	0.1	-1.4	-0.9	-1.4	-2.4	-0.5	-0.1	-1.1	-1.2	-1.2
Ever had stillbirth, spontaneous miscarriage or termination	1.5	1.6	6.5	-1.8	0.6	-0.1	-1.6	0.5	1.4	1.0	-2.5	-0.8	-0.2	0.7	-0.2	-0.4	-0.8	-0.3	2.4	-1.7
Commuting to job workplace: Public transport	1.5	1.8	5.0	-1.2	-1.3	-1.5	-1.1	-1.4	-1.8	-0.8	0.7	-1.3	-0.4	-2.1	-2.2	-0.5	-0.1	-1.4	-1.6	-1.0
Blood Eosinophil Count	1.3	9.9	25.8	5.0	2.4	3.6	4.8	2.5	1.4	1.6	2.8	4.5	2.7	1.2	2.8	2.4	2.1	3.4	0.9	5.1
Hearing difficulty/problems with background noise	1.3	2.0	4.5	1.2	1.8	2.1	1.4	1.7	1.3	1.5	-0.8	1.5	1.4	0.5	1.1	0.8	1.2	2.1	1.6	1.1
Weight	1.3	6.2	18.5	-1.2	-3.1	-3.0	-1.7	-3.0	-4.3	-3.1	2.2	-1.9	-2.4	-2.6	-2.1	-2.1	-2.2	-2.8	-1.0	-1.5
Forced expiratory volume in 1-second (FEV1), Best measure	1.3	4.1	12.9	-3.6	-0.9	-1.5	-3.3	-1.2	-0.1	0.2	-2.3	-2.8	-1.1	-0.7	-1.8	-1.9	-1.9	-1.4	1.2	-3.6
Hypothyroidism/myxoedema (self-reported)	1.3	2.6	5.9	-0.6	-1.8	-1.9	-0.9	-1.8	-1.3	-2.0	1.3	-0.8	-1.9	-2.4	-2.1	-1.4	-2.2	-1.8	-0.5	-0.8
Age at first live birth	1.3	2.2	7.5	-0.0	-1.9	-1.9	-0.5	-1.7	-1.7	-1.6	2.1	-0.7	-1.2	-1.3	-1.1	-0.9	-1.6	-1.6	-2.7	-0.2
Pulse rate, automated reading	1.3	4.1	13.5	3.7	1.0	2.0	3.4	1.4	1.2	0.5	2.1	2.9	1.0	1.1	1.6	1.6	1.0	2.0	0.1	3.5
Commuting to job workplace: Car/motor vehicle	1.3	1.5	4.0	1.1	1.3	1.6	1.1	1.4	1.1	1.1	-0.8	0.9	1.0	1.7	2.0	0.8	0.8	1.4	1.2	0.8
Knee pain experienced in last month	1.3	1.9	3.5	1.1	1.6	1.3	1.1	1.8	1.7	1.4	-1.1	1.5	1.3	1.6	1.0	1.9	1.5	1.6	0.5	0.8
Ever taken oral contraceptive pill	1.3	1.4	4.7	-1.1	-1.1	-1.1	-1.3	-1.3	-2.2	-1.5	0.2	-1.3	-1.5	-0.7	-0.4	-1.2	-1.1	-1.4	0.4	-1.1
Alzheimer’s Disease (in mother)	1.2	1.4	3.1	-0.6	-1.3	-1.2	-1.0	-1.4	-1.1	-1.0	0.9	-1.2	-0.9	-1.8	-0.4	-1.7	-1.7	-1.3	-0.3	-0.8
Breastfed as a baby	1.2	1.4	4.6	-1.5	-0.9	-0.6	-1.5	-1.0	-0.3	-0.6	-0.9	-2.1	-0.7	-1.1	-0.9	-1.8	-1.2	-0.5	-0.3	-2.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.8	3.8	1.1	1.5	1.2	1.3	1.5	1.2	1.2	-0.5	1.1	1.6	1.1	0.9	1.5	1.6	1.6	2.0	1.2
Chronic bronchitis/emphysema (mother)	1.2	1.4	4.3	-0.5	-1.2	-0.9	-0.7	-1.4	-1.4	-1.1	1.2	-0.9	-1.0	-2.1	-0.8	-1.8	-1.4	-1.2	0.5	-0.4
Leg fat percentage (right)	1.2	4.4	9.7	3.1	1.6	2.1	3.1	1.9	-0.2	0.6	1.0	3.1	1.8	1.7	1.5	2.7	2.4	2.0	0.4	3.0
Family relationship satisfaction	1.2	1.4	3.8	-1.9	-0.3	-0.9	-1.9	-0.5	-0.6	0.5	-1.7	-1.4	-0.7	-0.3	0.2	-1.4	-1.6	-1.0	0.8	-2.0
Mineral and other dietary supplements	1.2	1.6	4.3	-0.4	-1.6	-0.7	-0.4	-1.8	-1.5	-2.1	1.5	-1.2	-1.3	-1.4	-1.3	-1.8	-1.1	-0.7	-0.5	-0.2
Fractured/broken bones in last 5 years	1.2	1.6	3.7	1.9	0.8	0.9	1.7	1.0	1.3	0.8	0.8	1.9	0.5	1.2	0.8	1.5	0.9	0.9	-1.0	1.9
Deep venous thrombosis (DVT) (self-reported)	1.2	1.5	6.5	2.2	-0.5	0.3	1.7	-0.2	-0.4	-0.9	2.5	1.4	0.0	0.0	0.8	0.5	0.4	0.3	-1.8	2.0
Impedance of whole body	1.2	6.0	13.8	-0.5	3.1	2.9	0.3	2.9	2.9	3.7	-3.6	0.5	2.3	2.9	0.9	2.1	2.9	2.4	2.5	-0.3
Crohns Disease (2012)	1.1	1.7	4.3	2.1	1.0	1.2	1.9	1.3	0.4	1.2	0.6	2.1	0.6	0.9	1.2	1.4	1.3	1.2	-0.0	2.0
Fasting Glucose	1.1	1.3	3.7	-0.6	-1.1	-1.4	-1.0	-1.1	-1.5	-1.0	0.4	-0.6	-1.5	-0.8	-1.3	-0.5	-0.9	-1.7	-1.9	-0.7
Mouth/teeth dental problems	1.1	1.7	6.0	-1.6	-1.1	-0.6	-1.6	-1.5	-0.7	-1.2	0.2	-1.8	-1.3	-0.9	-0.0	-2.4	-1.8	-1.2	-0.2	-1.3
Medication: Ramipril	1.1	1.4	4.7	1.3	1.0	0.7	1.5	1.2	-0.1	1.1	-0.3	1.3	1.5	0.7	-0.1	2.0	2.2	1.2	0.3	1.3
Illnesses of mother	1.1	1.4	3.5	0.9	1.2	1.2	1.1	1.3	1.5	1.2	-0.7	1.1	0.8	1.9	0.7	1.7	1.4	1.3	0.5	0.9
Gout (self-reported)	1.1	1.5	3.6	1.3	1.2	1.1	1.5	1.3	0.8	0.9	-0.3	1.3	1.4	0.9	0.2	1.9	1.9	1.4	0.5	1.2
Guilty feelings	1.1	1.6	3.7	0.2	1.5	0.8	0.3	1.6	1.5	1.3	-1.5	0.7	1.7	1.9	1.7	1.6	1.5	1.0	0.1	0.2
Illnesses of father: High blood pressure	1.1	1.4	3.5	1.3	1.2	1.0	1.3	1.3	0.6	0.4	-0.2	1.5	1.5	1.2	0.8	1.9	1.4	0.9	0.1	1.4
Alcohol drinker status: Never	1.1	1.3	2.8	-1.1	-1.2	-1.3	-1.1	-1.2	-0.6	-1.0	0.3	-0.8	-1.3	-0.9	-1.4	-0.9	-1.3	-1.5	-1.7	-0.9
Ever depressed for a whole week	1.1	1.4	6.2	-2.1	0.3	-0.3	-1.9	-0.0	-0.4	0.5	-2.5	-1.4	0.1	0.2	0.2	-0.9	-0.6	-0.7	0.9	-2.0
Heart attack/myocardial infarction (self-reported)	1.1	1.4	3.8	1.0	1.4	1.0	1.2	1.3	0.5	1.2	-0.7	1.2	1.3	1.1	0.1	1.8	2.0	1.0	1.2	1.1
Irritable Bowel Disease (IBD)	1.0	2.3	5.6	2.2	0.5	0.5	2.2	1.1	-1.0	0.3	1.5	2.3	1.2	0.5	0.4	2.4	2.2	0.9	-1.2	2.0
Respiratory disease	1.0	2.3	4.2	-0.4	-1.9	-1.7	-0.8	-2.0	-1.8	-1.7	2.1	-1.1	-1.3	-1.8	-0.2	-1.9	-1.9	-1.7	-0.8	-0.4
Hair Pigment	1.0	29.7	169.2	-6.5	4.7	5.6	-3.9	3.2	6.6	3.3	-13.0	-3.3	3.2	6.3	0.5	-2.8	1.8	4.6	4.7	-6.7
Mouth/teeth dental problems: Dentures	1.0	1.7	6.9	1.6	1.0	0.3	1.4	1.6	0.6	0.6	-0.2	2.2	0.4	1.8	0.4	2.6	1.1	0.6	-0.2	1.5
Loud music exposure frequency	1.0	1.1	3.6	-0.4	1.5	1.0	0.0	1.5	0.9	1.5	-1.9	0.3	1.1	0.8	0.3	1.1	1.3	0.7	1.0	-0.1
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	3.6	-1.0	-1.5	-1.9	-1.2	-1.5	-1.9	-0.9	0.5	-1.3	-1.1	-0.8	-1.5	-1.1	-0.8	-1.4	-0.4	-1.2
Leg fat percentage (left)	1.0	3.7	9.8	3.1	1.1	1.7	3.0	1.5	-0.5	0.2	1.6	2.9	1.4	1.1	1.2	2.4	2.0	1.7	-0.0	3.1
Age started oral contraceptive pill	1.0	1.3	6.2	-0.3	-1.3	-1.3	-0.4	-1.2	-1.2	-1.5	0.7	-0.4	-1.2	-0.3	-1.5	-0.1	-0.4	-1.4	-2.5	-0.5
Alzheimer’s Disease (in father)	0.9	1.0	3.2	0.0	-1.1	-1.4	-0.2	-0.8	-1.3	-1.0	1.1	-0.4	-1.3	-1.2	-1.8	0.2	0.1	-0.9	-1.2	-0.1
HDL Cholesterol	0.9	1.4	3.7	-0.3	1.5	0.9	0.1	1.4	1.3	1.6	-1.9	0.1	1.5	1.3	1.0	1.2	1.5	0.7	1.3	-0.1
Rheumatoid Arthritis	0.9	1.2	5.3	1.5	-0.4	-0.8	1.2	-0.3	0.5	-0.3	2.2	1.3	-0.3	0.4	0.8	0.5	-0.4	0.0	-2.3	1.7
Ever used hormone-replacement therapy (HRT)	0.9	1.2	4.2	1.8	-0.2	0.4	1.5	-0.3	-0.0	-1.0	2.0	1.7	-0.4	-0.2	0.2	0.2	-0.0	-0.1	-1.4	2.0
Medication: Co-codamol	0.9	1.0	2.6	1.1	0.9	1.0	1.3	0.9	1.0	1.1	-0.1	1.6	0.4	0.7	-0.6	1.5	1.1	0.8	0.3	1.4
Supplements: Glucosamine	0.9	1.2	3.6	0.6	1.4	0.6	0.4	1.4	0.6	1.5	-0.9	1.1	1.4	1.4	1.9	1.4	0.8	0.5	0.3	0.6
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	4.2	0.5	-1.4	-1.1	0.2	-1.3	-0.8	-0.9	2.0	-0.2	-1.1	-1.7	-1.1	-0.8	-1.2	-1.0	-1.1	0.4
Father’s age at death	0.9	1.2	4.2	-1.7	-0.1	-0.2	-1.6	-0.3	1.4	0.4	-1.9	-1.7	-0.0	0.7	-0.0	-0.9	-0.5	-0.2	0.4	-2.0
Medication: Cholesterol lowering	0.9	1.4	4.5	1.5	0.7	0.7	1.5	1.0	-0.8	-0.2	0.6	1.8	0.6	1.0	-0.1	2.1	1.7	0.7	0.4	1.6
Depression (self-reported)	0.9	1.1	3.2	0.6	1.2	0.8	0.7	1.2	1.5	1.1	-0.7	0.5	1.2	1.0	0.9	1.1	1.1	1.1	1.8	0.6
Pulse wave reflection index	0.9	1.1	3.6	0.2	1.4	0.7	0.4	1.2	0.6	1.9	-1.3	0.5	1.1	1.4	1.1	1.0	1.2	1.0	1.2	0.2
Ever highly irritable/argumentative for 2 days	0.9	1.1	5.0	-1.0	1.0	0.3	-0.7	1.0	1.3	1.3	-2.2	-0.3	0.6	1.3	0.0	0.8	0.5	0.2	1.7	-0.9
Blood clot in the leg (DVT)	0.9	1.1	5.1	1.8	-0.6	0.2	1.4	-0.4	-0.5	-0.9	2.3	1.1	-0.2	-0.1	0.5	0.3	0.3	0.1	-1.7	1.6
Headache pain in last month	0.9	1.6	5.1	0.9	1.1	0.5	1.1	1.5	0.5	1.7	-0.8	1.0	1.9	0.2	-0.3	2.1	2.3	1.6	-0.3	0.6
Medication: Seretide 50 evohaler	0.9	1.1	2.5	1.5	0.7	1.2	1.3	0.5	1.0	0.8	0.7	1.2	0.5	1.3	1.6	0.2	0.2	0.9	0.3	1.6
Supplements: Vitamin C	0.9	1.1	2.9	-1.0	-0.9	-1.7	-1.1	-0.9	-0.8	-0.6	0.2	-0.8	0.1	-1.4	-0.2	-0.7	-1.4	-1.4	-1.5	-1.0
Mood swings	0.9	1.7	3.0	0.6	1.7	1.4	0.8	1.7	1.4	1.4	-1.4	1.3	1.4	1.6	1.3	1.1	0.8	1.4	1.2	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.0	1.7	0.9	0.9	1.2	1.0	1.2	1.2	1.1	-0.1	1.0	1.2	0.5	1.2	1.3	0.8	1.1	0.9	1.0
Osteoarthritis (self-reported)	0.9	1.1	2.3	0.8	1.5	1.5	0.9	1.3	0.4	1.0	-0.8	0.7	1.5	0.6	1.2	0.8	1.2	1.4	0.8	0.8
Ulcerative Colitis (UC)	0.8	1.4	4.8	1.4	0.7	0.4	1.5	1.2	-0.5	0.2	0.6	1.5	1.1	1.2	0.5	2.2	2.1	1.0	-0.6	1.3
Body Mass Index (BMI) (2010)	0.8	1.1	2.6	-1.0	-1.1	-1.6	-1.3	-0.9	-0.8	-1.2	0.1	-1.0	-1.1	-1.0	-0.5	-0.7	-1.4	-1.2	0.0	-1.4
Current tobacco smoking	0.8	1.3	6.3	-0.2	1.4	1.1	0.0	1.4	1.4	0.7	-1.9	0.5	1.0	1.0	0.4	0.9	1.0	1.1	2.5	-0.3
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.2	2.9	0.5	1.3	0.7	0.6	1.4	0.6	1.2	-1.1	0.5	1.7	1.3	0.9	1.6	1.5	1.2	0.7	0.4
Had menopause	0.8	0.9	2.6	0.8	0.7	0.9	0.9	1.0	0.6	0.1	-0.4	1.6	0.8	1.2	-0.2	1.6	1.4	0.5	-1.4	0.8
Tense / ‘highly strung’	0.8	1.3	3.6	0.2	1.4	1.2	0.5	1.2	1.1	1.0	-1.6	0.3	1.3	1.9	0.4	1.1	1.6	1.4	1.2	0.2
Qualifications: NVQ or HND or HNC or equivalent	0.8	0.9	3.3	-1.6	-0.2	-0.8	-1.5	-0.1	-0.7	-0.2	-1.8	-0.7	-0.4	0.2	-1.3	0.2	-0.0	-1.0	0.6	-1.6
Loneliness, isolation	0.8	1.1	3.0	1.1	1.2	1.1	1.0	1.1	0.3	1.1	-0.2	1.3	1.5	0.9	1.7	0.8	0.8	1.0	0.4	1.2
Number of self-reported non-cancer illnesses	0.8	1.4	4.9	0.7	1.3	0.8	0.8	1.5	-0.1	1.2	-1.1	0.8	1.3	1.1	0.2	2.2	2.1	1.1	1.1	0.6
Supplements: Calcium	0.8	0.9	3.1	0.1	1.0	0.4	0.4	1.2	0.5	1.4	-1.3	1.2	0.9	0.6	-0.4	1.8	1.1	0.5	-0.8	0.2
Schizophrenia vs Biploar Disorder	0.7	0.9	5.3	-0.5	-1.0	-1.3	-0.3	-0.7	-1.5	-1.3	0.1	-0.3	-0.9	-0.4	-2.3	0.2	0.2	-0.5	-1.0	-0.6
Lupus	0.7	1.0	1.8	-1.2	-0.9	-1.0	-1.3	-0.9	-1.3	-1.3	-0.3	-1.3	-0.7	-0.5	-0.7	-0.5	-0.4	-1.1	-1.4	-1.2
Type 2 Diabetes (T2D) (2012)	0.7	0.8	2.8	-0.9	-0.6	-0.6	-1.0	-1.0	-1.7	-0.8	0.2	-0.8	-0.7	-0.4	0.5	-1.6	-1.2	-0.8	-0.2	-0.4
Diabetes (mother)	0.7	0.9	2.3	-0.5	-1.0	-1.2	-0.8	-0.9	-1.5	-1.4	0.7	-0.8	-1.4	-0.5	-0.7	-0.5	-0.7	-1.0	-0.3	-0.6
Severe depression (siblings)	0.7	0.8	2.3	0.7	1.0	0.6	0.8	1.2	0.8	0.4	-0.5	1.0	0.8	1.1	0.5	1.5	1.1	0.9	0.9	0.7
Stomach or abdominal pain in last month	0.7	0.9	3.1	-0.2	1.2	0.2	0.0	1.1	1.0	1.8	-1.3	0.6	1.2	0.3	0.3	1.2	0.9	0.5	1.5	0.0
Had other major operations	0.7	0.8	1.9	1.0	0.8	0.6	1.0	0.8	1.2	0.8	-0.0	1.4	1.1	1.0	0.3	1.4	0.9	0.6	-0.3	1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.6	2.9	1.5	1.2	1.4	1.5	1.3	0.4	0.9	0.0	1.2	1.4	1.3	1.7	1.2	1.3	1.3	0.9	1.5
Diabetes (self-reported)	0.7	1.1	4.4	-0.5	-1.2	-1.4	-0.5	-1.0	-2.1	-1.5	0.5	-0.9	-0.8	-0.6	-1.2	-0.2	0.1	-1.0	-1.3	-0.5
Length of working week for main job	0.7	0.8	3.0	-0.4	-0.9	-0.5	-0.6	-1.1	-1.7	-0.7	0.5	-1.4	-0.4	-1.5	0.0	-1.3	-0.4	-0.2	-0.6	-0.6
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	4.4	-1.0	-1.0	-0.9	-1.2	-1.3	0.6	-0.1	0.3	-1.1	-0.9	-1.0	0.1	-1.9	-2.1	-1.0	-0.8	-0.9
Medication: Amlodipine	0.7	0.9	3.7	0.1	1.1	1.1	0.4	1.0	0.4	0.4	-1.5	0.3	0.6	1.9	0.2	1.1	1.8	0.8	0.2	0.3
Wheeze or whistling in the chest in last year	0.7	1.2	3.6	1.9	0.7	0.9	1.7	0.7	0.2	0.6	1.2	1.2	1.1	-0.3	1.0	0.9	0.7	1.0	1.3	1.9
Medication: Blood pressure	0.7	1.3	6.1	0.4	1.2	0.8	0.7	1.4	-0.6	0.4	-1.0	0.5	1.2	1.6	-0.0	1.9	2.5	1.0	0.4	0.5
Age at last live birth	0.7	1.0	2.0	-1.3	-0.8	-1.3	-1.4	-0.9	-0.7	-0.4	-0.4	-1.3	-0.4	-0.6	-0.5	-1.0	-1.2	-1.2	-1.0	-1.4
Eye problems/disorders: Cataract	0.7	0.8	2.1	0.6	1.0	1.1	0.7	0.9	1.1	1.2	-0.6	0.7	1.0	1.5	0.8	0.7	0.6	1.0	0.1	0.5
Illnesses of father: None of the above (group 1)	0.7	0.9	3.4	-1.3	-0.6	-0.5	-1.1	-0.8	0.0	-0.2	-0.2	-1.2	-1.2	-0.5	-0.4	-1.8	-1.3	-0.6	0.9	-1.4
Alcohol drinker status: Previous	0.7	0.8	3.4	-1.1	0.6	-0.4	-1.0	0.7	0.1	0.9	-1.8	-0.6	0.5	0.6	-0.7	1.2	0.9	-0.1	1.1	-1.2
HbA1C	0.6	0.7	2.8	1.3	0.3	0.6	1.0	0.3	-0.2	0.4	1.2	1.4	-0.3	0.5	0.8	0.4	0.2	-0.1	0.5	1.7
Neuroticism (2016)	0.6	0.9	3.1	-1.1	-0.7	-1.8	-1.0	-0.4	-0.7	-0.3	-0.8	-0.7	-0.4	-0.2	-1.3	0.6	-0.3	-1.3	-1.4	-1.1
Waist Hip Ratio (WHR)	0.6	2.5	5.8	-2.4	-1.2	-1.5	-2.3	-1.2	-1.1	-0.9	-0.9	-2.0	-1.3	-0.9	-2.2	-1.0	-1.0	-1.8	-0.5	-2.4
Systolic Blood Pressure	0.6	3.1	17.2	-0.1	1.0	-0.4	0.4	1.6	-0.6	0.8	-1.5	1.1	1.2	1.5	-2.0	4.1	4.0	0.3	-1.8	0.3
Type 2 Diabetes (T2D) (2018)	0.6	1.1	3.9	-1.3	-0.7	-1.4	-1.3	-0.8	-2.0	-1.1	-0.6	-1.2	-1.0	0.2	-0.6	-0.5	-0.4	-1.4	-0.5	-1.1
Systolic blood pressure, automated reading	0.6	1.7	8.6	0.9	0.8	0.2	1.1	1.3	-0.4	-0.1	-0.1	1.4	1.2	1.1	-0.6	2.9	2.6	0.6	-1.6	1.1
Medication: Levothyroxine sodium	0.6	1.0	2.3	-0.5	-1.1	-1.4	-0.5	-1.0	-0.9	-1.0	0.5	-0.7	-1.2	-1.4	-1.5	-0.8	-1.3	-1.0	-0.4	-0.6
Impedance of arm (right)	0.6	2.8	13.2	-2.5	1.3	1.3	-1.8	0.8	1.3	2.1	-3.6	-1.6	0.4	1.6	-0.3	-0.4	0.8	0.6	2.1	-2.2
Happiness	0.6	0.8	4.1	-1.4	0.6	-0.1	-1.0	0.5	-0.5	0.8	-2.0	-0.6	0.6	0.7	0.4	-0.2	0.2	0.3	1.1	-1.4
Asthma	0.6	1.1	6.6	1.3	-0.9	-0.4	0.9	-1.0	-1.0	-0.9	2.6	0.4	-0.5	-1.3	0.3	-0.8	-0.9	-0.3	-0.6	1.3
Arm fat mass (right)	0.6	2.3	8.4	0.8	-1.8	-1.1	0.4	-1.7	-2.9	-2.4	2.7	0.0	-1.2	-1.7	-0.7	-1.0	-1.2	-1.1	-0.9	0.6
High blood pressure (siblings)	0.6	0.8	3.4	1.2	-0.5	-0.1	0.9	-0.4	-0.5	-1.5	1.8	0.7	-0.7	-0.9	0.4	-0.7	-1.0	0.0	-0.1	1.2
Heart disease (mother)	0.6	0.8	2.7	0.7	-0.9	-0.9	0.2	-0.7	-1.0	-0.8	1.6	0.4	-1.3	-0.9	-0.4	-0.5	-1.2	-0.8	-0.7	0.5
Smoking status: Current	0.6	1.0	4.1	-0.2	1.1	1.1	0.0	1.1	1.4	0.6	-1.6	0.5	0.8	0.8	0.4	0.6	0.7	1.0	2.0	-0.3
Arm fat mass (left)	0.6	2.4	9.5	1.1	-1.8	-1.1	0.6	-1.7	-2.7	-2.2	3.1	0.2	-1.3	-1.7	-0.4	-1.0	-1.3	-1.1	-0.9	0.9
Mother’s age at death	0.6	0.7	2.1	0.3	-1.0	-0.4	0.2	-1.1	-0.4	-0.8	1.4	-0.9	-0.8	-1.4	-0.6	-1.2	-0.4	-0.0	-1.3	0.1
Eye problems/disorders: Glaucoma	0.6	0.7	4.5	-0.5	-0.9	-1.0	-0.3	-0.6	-0.6	-0.4	0.2	-0.2	-0.7	-0.7	-2.1	0.4	0.2	-0.9	-1.4	-0.5
Number of operations (self-reported)	0.6	1.0	2.0	1.1	1.0	1.0	1.1	1.1	1.4	0.9	-0.4	1.2	1.1	0.7	0.6	1.2	0.8	1.0	0.2	1.0
Crohns Disease (2017)	0.5	1.0	2.8	1.5	-0.1	-0.0	1.4	0.2	-1.3	0.3	1.5	1.7	0.5	-0.5	0.1	1.2	1.0	-0.0	-1.3	1.5
Blood White Count	0.5	3.7	10.7	3.2	1.1	1.8	3.0	1.4	-0.7	-0.3	1.9	2.8	1.6	0.9	1.4	2.2	1.5	1.4	-0.2	3.3
Average weekly spirits intake	0.5	0.6	1.7	-0.6	-0.7	-1.1	-0.7	-0.6	-1.0	-1.0	0.4	-0.2	-0.8	-0.9	-0.0	-0.5	-1.3	-1.0	-0.3	-0.4
Average weekly fortified wine intake	0.5	0.6	2.3	-0.0	-0.9	-0.7	-0.1	-0.8	-0.3	-0.8	1.2	0.1	-1.5	-0.5	-0.9	-0.7	-1.2	-0.9	-0.1	0.2
Maternal smoking around birth	0.5	0.7	2.1	1.0	0.5	0.5	1.1	0.8	0.4	0.4	0.2	1.3	0.5	1.2	-0.2	1.5	1.1	0.3	-0.2	1.0
Body mass index (BMI)	0.5	2.1	9.3	2.3	-1.0	-0.2	1.8	-0.8	-2.0	-1.9	3.0	1.4	-0.4	-0.9	0.5	-0.0	-0.5	-0.1	-1.0	2.0
Waist circumference	0.5	2.0	7.4	-0.3	-1.8	-1.5	-0.5	-1.7	-2.7	-2.0	1.5	-0.7	-1.3	-1.4	-1.3	-0.8	-1.1	-1.5	-1.0	-0.4
Number of live births	0.5	0.6	1.9	-0.3	1.0	0.9	-0.1	0.9	0.7	1.4	-1.4	0.5	0.7	1.0	0.3	0.8	1.0	0.4	0.5	-0.1
Qualifications: A levels/AS levels or equivalent	0.5	1.1	3.2	-0.6	-1.0	-1.1	-0.9	-1.1	-0.9	-0.3	0.7	-0.8	-1.3	-1.0	-0.5	-1.7	-1.8	-1.3	0.4	-0.7
Impedance of arm (left)	0.5	2.5	7.3	-0.9	1.7	2.1	-0.4	1.4	2.2	2.7	-2.6	-0.4	1.0	1.9	1.1	0.1	1.0	1.4	2.0	-0.7
Peak expiratory flow (PEF)	0.5	1.1	3.1	-1.7	-0.3	-0.4	-1.7	-0.5	-0.0	-0.3	-1.0	-1.5	-0.6	0.1	0.0	-1.3	-1.2	-0.6	1.4	-1.7
Worry too long after embarrassment	0.5	0.9	2.7	0.7	0.8	0.4	0.7	1.0	1.6	1.0	-0.3	0.7	1.0	1.4	0.7	1.4	1.0	0.9	-0.3	0.6
Eye problems/disorders: None of the above	0.5	0.5	1.2	-0.8	-0.9	-1.1	-1.0	-0.7	-0.2	-0.7	0.2	-0.6	-0.7	-0.9	-0.3	-0.5	-0.8	-1.0	-0.5	-0.7
Angina (self-reported)	0.5	0.6	1.5	1.0	-0.1	-0.2	1.0	0.1	-1.1	-0.5	0.9	0.9	0.2	-0.4	-1.0	1.2	1.1	0.2	-0.2	1.1
Number of full sisters	0.5	0.6	2.7	-0.7	-0.5	-1.0	-0.9	-0.5	0.4	-0.7	0.0	-0.1	-0.5	-0.8	-0.3	-0.7	-1.6	-1.1	-0.3	-0.6
Illnesses of father: Heart disease	0.5	0.7	2.8	1.5	0.3	0.9	1.4	0.3	-0.1	0.3	1.3	1.2	0.2	0.4	0.4	0.6	0.4	0.6	0.0	1.7
Asthma (self-reported)	0.5	1.1	6.0	1.1	-1.0	-0.6	0.7	-1.1	-1.0	-1.0	2.4	0.2	-0.6	-1.5	0.1	-0.8	-0.9	-0.5	-0.8	1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.2	4.4	-1.5	0.5	0.5	-1.2	0.3	1.4	0.4	-2.1	-1.1	0.6	-0.0	0.8	-1.4	-1.2	0.3	0.8	-1.5
Medication: Bendroflumethiazide	0.5	0.7	2.8	-1.0	-0.6	-1.0	-1.0	-0.4	-1.7	-0.5	-0.5	-0.4	-0.3	-0.7	-1.3	0.2	-0.0	-1.1	-1.0	-1.0
Average weekly beer plus cider intake	0.5	0.7	2.5	-0.0	0.9	0.4	0.2	1.0	0.5	0.7	-1.6	0.5	0.7	1.3	-0.1	1.4	1.3	0.5	0.3	-0.1
Risk taking	0.5	0.8	2.1	0.9	0.9	1.1	1.1	0.9	0.7	0.6	-0.3	1.0	0.8	0.8	0.2	0.9	1.4	1.1	0.6	0.8
Diastolic blood pressure, automated reading	0.5	1.7	7.2	1.9	-0.8	-0.5	1.5	-0.5	-1.3	-1.6	2.7	1.5	-0.5	-0.5	-0.1	0.4	-0.2	-0.2	-1.8	1.8
Heart disease (siblings)	0.5	0.6	3.6	1.0	0.6	0.9	0.8	0.5	0.3	-0.4	0.4	0.3	0.7	1.0	1.9	0.0	0.5	1.1	0.6	0.8
Bipolar Disorder (2018)	0.4	0.7	4.0	0.6	-0.8	-0.8	0.1	-0.8	-0.1	-0.6	2.0	0.1	-0.3	-1.0	0.6	-0.6	-1.0	-0.6	-1.2	0.6
Schizophrenia (2018)	0.4	0.8	4.4	0.1	0.6	-0.3	0.3	0.8	-0.5	0.4	-1.1	0.6	1.0	1.1	-0.9	2.1	1.7	0.4	-0.8	-0.0
Worry (Nagel 2018)	0.4	0.8	2.3	-1.4	-0.6	-1.1	-1.2	-0.6	0.6	-1.0	-1.0	-1.2	-0.7	0.1	-1.3	-0.5	-0.2	-0.2	-0.1	-1.5
Neuroticism	0.4	1.0	2.1	-1.5	-0.8	-1.1	-1.4	-0.8	-0.0	-1.2	-0.6	-1.2	-0.7	-0.4	-0.7	-1.0	-1.1	-0.9	-0.5	-1.5
Sensitivity / hurt feelings	0.4	0.6	2.0	-1.4	0.1	-0.4	-1.3	-0.0	-0.3	-0.2	-1.2	-1.3	-0.2	0.9	-0.2	-0.0	0.0	-0.5	0.5	-1.4
Supplements: Zinc	0.4	0.4	2.4	-0.1	-0.7	-1.5	-0.4	-0.5	-0.5	-0.1	0.7	-0.2	-0.5	-0.8	-0.3	-0.0	-0.7	-0.8	-0.9	-0.2
Medication: Metformin	0.4	0.6	2.5	-0.2	-0.9	-1.0	-0.2	-0.7	-1.5	-1.3	0.4	-0.5	-0.2	-0.1	-0.7	0.1	0.2	-0.6	-1.6	-0.2
Age when periods started (menarche)	0.4	1.1	4.0	-0.8	1.2	1.2	-0.3	0.9	1.4	1.1	-2.0	-0.3	1.8	0.7	1.0	0.1	0.6	0.9	0.3	-0.6
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	1.5	0.7	-0.5	0.0	0.3	-0.7	-0.4	-0.4	1.2	0.4	-0.2	-0.8	0.6	-0.6	-0.9	-0.2	-1.1	0.8
Trunk fat mass	0.4	1.6	7.3	0.1	-1.6	-1.0	-0.2	-1.5	-2.7	-1.7	1.8	-0.5	-1.2	-1.3	-0.9	-0.8	-0.9	-1.2	-0.4	-0.0
Number of incorrect matches in round	0.4	0.7	2.1	-1.4	-0.6	-0.8	-1.2	-0.7	-0.9	-0.7	-0.4	-1.4	-0.3	-0.9	-1.0	-0.5	-0.1	-0.8	-0.3	-1.1
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	3.3	-0.8	0.6	-0.1	-0.7	0.7	0.9	0.6	-1.8	-0.5	0.7	0.5	0.3	0.2	0.2	0.3	0.6	-1.0
Medication: Simvastatin	0.4	0.6	2.6	0.7	-0.2	-0.2	0.7	0.2	-1.4	-0.4	0.4	0.9	-0.4	0.5	-1.1	1.6	1.1	-0.2	0.0	0.7
Glaucoma (self-reported)	0.4	0.5	1.6	-0.5	-0.7	-1.0	-0.5	-0.6	-0.8	-0.5	0.0	-0.4	-0.6	-0.3	-1.3	0.2	-0.0	-1.1	-0.8	-0.6
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.3	1.2	-0.1	0.1	1.0	0.2	0.0	-0.3	1.1	0.7	0.5	0.3	-0.2	0.9	0.7	0.5	-0.9	1.1
Qualifications: College or University degree	0.4	1.1	2.7	0.0	-1.3	-1.5	-0.4	-1.5	-0.8	-0.5	1.7	-0.4	-1.4	-1.2	-1.0	-1.0	-1.5	-1.3	-0.2	-0.0
Suffer from ‘nerves’	0.4	0.6	2.0	-0.9	-0.7	-1.4	-0.9	-0.7	-0.2	-0.7	-0.1	-0.9	-0.6	0.1	-1.2	-0.1	0.0	-0.6	-0.8	-0.9
Arm fat percentage (left)	0.4	1.8	8.5	2.2	-0.7	0.5	1.8	-0.6	-1.4	-1.2	2.9	1.4	-0.4	-0.6	0.9	-0.4	-0.7	0.1	-0.6	2.1
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.3	-1.1	-0.6	-0.6	-0.9	-0.7	-0.4	-0.3	-0.3	-1.1	-0.8	-0.4	-1.0	-0.8	-0.5	-0.5	-0.0	-1.0
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	2.5	-0.3	0.8	0.1	-0.2	0.8	0.5	1.6	-1.1	-0.1	0.6	0.1	-0.3	0.9	1.1	0.4	1.2	-0.4
Medication for cholesterol	0.4	0.5	2.3	-1.1	-0.2	-0.3	-1.0	-0.4	0.7	-0.2	-0.6	-1.5	-0.0	-0.0	0.2	-1.0	-0.6	0.1	0.7	-1.3
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.4	-0.1	0.7	-0.3	-0.2	0.9	0.7	0.9	-1.2	0.5	0.7	0.7	0.7	1.2	0.4	0.2	-0.1	-0.4
Ovarian Cancer	0.3	0.5	2.9	-0.5	0.1	0.3	-0.3	0.0	-1.0	0.3	-0.8	-0.7	0.1	-0.5	-1.1	-0.2	0.4	0.4	1.7	-0.7
Age at First Birth	0.3	0.5	1.3	0.2	-0.8	-0.6	-0.0	-0.7	0.4	-0.7	1.1	-0.5	-0.7	-0.9	-0.5	-0.8	-0.9	-0.3	-1.0	-0.0
Schizophrenia (2014)	0.3	0.7	3.6	0.1	0.6	-0.2	0.4	0.8	-0.1	0.5	-1.0	0.7	1.1	1.1	-0.6	1.9	1.4	0.6	-0.5	0.1
Blood Red Count	0.3	3.0	8.8	0.9	1.8	3.0	1.1	2.1	1.7	1.6	-1.6	2.5	1.6	2.2	2.1	1.6	0.9	1.6	0.5	0.9
BMI	0.3	2.0	7.5	1.0	-1.6	-1.3	0.4	-1.5	-2.4	-2.2	2.7	0.3	-0.9	-1.6	-0.1	-0.8	-1.5	-1.2	-0.7	0.8
Relative age of first facial hair	0.3	0.6	2.4	0.3	0.8	1.3	0.4	0.4	1.6	0.6	-0.7	-0.0	0.8	0.7	1.1	-0.8	-0.1	1.0	1.0	0.1
Angina	0.3	0.4	1.3	0.6	-0.0	-0.3	0.6	0.1	-1.1	-0.5	0.5	0.7	0.2	-0.4	-0.9	1.1	1.0	0.1	-0.0	0.8
Medication for hormone replacement therapy	0.3	0.3	0.7	-0.1	-0.7	-0.8	-0.3	-0.4	-0.7	-0.5	0.5	-0.1	-0.8	-0.7	-0.4	-0.1	-0.4	-0.8	-0.8	-0.0
Townsend deprivation index at recruitment	0.3	0.4	1.1	-0.1	0.7	0.3	0.0	0.6	0.9	0.8	-1.0	0.8	0.3	0.7	-0.3	0.6	0.6	0.3	0.7	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.6	0.9	-0.5	-0.3	0.5	-0.4	-0.7	-0.5	1.3	0.7	-0.5	-0.0	0.2	-0.0	-0.6	-0.4	-1.1	0.9
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	1.5	0.7	-0.7	-0.4	0.5	-0.5	-0.7	-0.8	1.2	0.2	-1.0	-0.4	-0.3	0.0	-0.3	-0.2	-0.9	0.7
High blood pressure (mother)	0.3	0.4	1.6	-0.1	0.8	0.3	-0.1	0.7	0.2	0.6	-0.7	-0.0	1.2	0.3	0.4	1.0	1.2	0.5	0.4	0.0
Nervous feelings	0.3	0.6	3.0	-0.7	0.2	-0.4	-0.5	0.3	1.3	0.1	-1.3	-0.4	0.0	1.7	-0.6	0.6	0.6	0.3	0.3	-0.8
Arm fat percentage (right)	0.3	1.4	6.0	1.5	-1.0	0.1	1.2	-0.9	-1.9	-1.6	2.4	0.9	-0.7	-0.8	0.2	-0.7	-0.7	-0.2	-0.6	1.5
Hip circumference	0.3	1.5	6.6	0.4	-1.5	-1.2	0.1	-1.5	-2.6	-1.9	1.9	-0.2	-0.9	-1.1	-0.6	-0.7	-0.9	-1.0	-0.3	0.3
Alcohol intake versus 10 years previously	0.3	0.5	1.4	1.2	0.3	1.1	1.2	0.1	0.5	0.3	0.8	0.5	0.6	-0.3	0.5	-0.3	0.1	1.0	0.7	1.1
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.4	1.2	0.4	0.2	1.0	0.5	-0.4	0.1	0.7	1.0	0.5	0.3	0.5	0.7	0.5	0.8	0.2	1.2
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	1.2	0.2	0.6	-0.1	0.3	0.7	0.8	0.7	-0.5	0.8	0.2	1.0	0.0	1.1	0.9	0.1	-0.5	0.3
Lung cancer (father)	0.3	0.3	1.5	-0.1	0.5	0.2	0.1	0.6	0.1	0.2	-0.6	0.3	0.4	0.8	-0.5	1.1	1.2	0.4	0.3	-0.0
Body fat percentage	0.3	1.0	3.3	1.8	-0.1	0.8	1.7	0.1	-1.3	-0.6	1.7	1.4	0.2	0.0	0.5	0.6	0.4	0.5	-0.1	1.7
Mouth/teeth dental problems: Loose teeth	0.3	0.3	1.3	0.1	0.6	0.5	-0.0	0.7	0.3	0.4	-0.6	-0.0	1.1	0.3	1.1	0.7	0.4	0.2	0.9	-0.0
Whole body fat mass	0.3	1.2	6.0	0.7	-1.3	-0.7	0.4	-1.2	-2.5	-1.6	2.0	0.2	-0.7	-1.1	-0.6	-0.4	-0.6	-0.8	-0.6	0.6
Leg fat mass (right)	0.3	1.1	4.4	1.5	-0.7	-0.3	1.2	-0.5	-2.1	-1.4	2.1	1.0	-0.2	-0.5	-0.1	0.4	0.1	-0.2	-0.4	1.3
Chest pain or discomfort	0.3	0.4	1.2	1.1	0.0	-0.1	1.0	-0.0	-0.5	-0.9	1.0	0.8	0.2	0.2	0.4	0.0	-0.2	0.4	0.2	1.1
Qualifications: nursing, teaching	0.3	0.4	1.5	1.2	0.0	0.1	1.0	0.1	-0.1	0.5	1.1	1.1	-0.3	0.2	-0.2	0.4	0.0	0.0	-0.6	1.2
Breast cancer (self-reported)	0.3	0.4	1.7	0.9	0.0	0.4	0.7	0.1	-0.0	-0.4	1.0	0.7	0.3	0.1	1.3	-0.3	-0.3	0.6	0.2	0.9
Osteoporosis (self-reported)	0.3	0.4	1.7	0.6	0.4	0.1	0.5	0.6	0.6	0.1	-0.1	1.1	0.6	0.3	0.2	0.9	-0.1	0.2	-1.3	0.6
Medication: Blood pressure	0.3	0.5	1.7	0.7	0.5	0.2	0.7	0.6	-0.6	0.4	-0.1	1.1	0.9	0.4	-0.2	1.3	1.1	0.2	-1.0	0.8
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.4	0.0	-0.3	-0.8	-0.0	-0.1	-1.1	-0.5	0.1	0.2	-0.8	0.0	-1.2	0.7	0.5	-0.6	0.9	-0.2
High cholesterol (Self-reported)	0.3	0.5	3.1	0.1	0.5	0.2	0.1	0.8	-0.6	0.2	-0.7	0.7	0.2	0.8	-0.3	1.8	1.3	-0.2	0.5	0.3
Medication: Lisinopril	0.3	0.3	1.5	0.1	-0.5	-0.7	0.0	-0.3	-1.2	-0.9	0.6	-0.4	-0.4	-0.2	-0.4	-0.0	0.5	-0.4	-1.2	0.1
Medication: Atorvastatin	0.3	0.4	2.0	-0.1	0.7	0.1	0.1	1.0	-0.1	0.4	-0.7	0.5	0.7	0.3	-0.1	1.4	1.1	0.4	0.6	0.2
Commuting to job workplace: Cycle	0.3	0.4	1.8	-0.7	-0.5	-1.3	-0.8	-0.3	0.0	0.2	0.2	-0.3	-0.7	-0.1	-0.2	0.2	-0.6	-0.9	-0.6	-0.5
Vascular/heart problems diagnosed by doctor	0.3	0.7	3.1	0.0	-0.4	0.3	-0.2	-0.6	1.6	0.0	0.8	-0.5	-0.3	-0.4	1.6	-1.6	-1.8	-0.0	-0.0	-0.1
Leg fat mass (left)	0.3	1.3	6.0	1.6	-0.9	-0.4	1.2	-0.7	-2.1	-1.5	2.5	0.9	-0.3	-0.8	-0.2	0.3	-0.1	-0.3	-0.6	1.4
Depression (Nagel 2018)	0.2	0.3	0.8	-0.2	-0.6	-0.8	-0.4	-0.6	-0.9	-0.6	0.3	-0.1	-0.9	-0.4	-0.6	-0.3	-0.7	-0.7	-0.6	-0.1
Major Depression (MDD)	0.2	0.2	0.9	-0.6	0.3	-0.3	-0.6	0.4	0.4	0.3	-0.9	-0.1	0.2	0.6	0.6	0.1	0.1	-0.0	0.1	-0.5
Breast Cancer	0.2	0.4	3.3	0.4	-0.6	-0.8	0.3	-0.4	-1.8	-0.8	1.0	-0.1	-0.5	-0.2	-0.3	0.0	0.0	-0.3	-0.0	0.3
Coronary Artery Disease (CAD)	0.2	0.2	1.5	0.2	-0.2	0.2	0.3	-0.2	-0.4	0.0	0.4	0.2	-0.1	-1.2	-0.9	-0.5	0.1	0.2	0.3	0.1
Mean Putamen Volume	0.2	0.2	1.3	-0.4	0.3	0.2	-0.4	0.2	-0.0	-0.0	-0.6	0.3	-0.4	0.8	-0.2	0.2	-0.1	-0.3	1.1	-0.3
Cardiovascular Disease	0.2	0.7	3.4	-0.0	0.2	-0.5	0.0	0.5	-1.8	-0.1	-0.5	0.6	-0.1	0.6	-1.3	1.7	1.4	-0.2	0.6	0.0
Relative age voice broke	0.2	0.3	1.1	-0.6	0.3	0.4	-0.3	0.3	1.0	0.2	-1.1	-0.2	0.1	0.4	-0.5	-0.4	0.2	0.4	0.3	-0.7
Financial difficulties in last 2 years	0.2	0.2	1.7	0.0	0.3	-0.4	-0.1	0.3	0.2	1.3	-0.3	0.5	0.2	0.3	0.1	0.7	0.2	-0.4	0.7	0.2
Worrier / anxious feelings	0.2	0.3	2.0	0.1	-0.2	-0.5	0.1	0.2	1.4	0.2	0.3	0.3	0.0	-0.0	-1.1	0.7	0.2	0.0	-1.1	0.1
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.9	0.8	0.1	0.4	0.9	0.1	-0.0	-0.2	0.8	0.6	0.5	-0.7	-0.2	0.3	0.3	0.4	0.2	0.8
Exposure to tobacco smoke outside home	0.2	0.2	0.9	0.2	0.2	0.1	0.2	0.2	-0.5	0.0	-0.2	-0.0	0.9	0.5	0.3	0.6	0.8	0.3	-1.0	0.2
Number of children fathered	0.2	0.2	0.8	0.9	-0.1	-0.2	0.8	0.2	0.1	0.4	0.7	0.5	0.6	-0.6	0.2	0.6	0.3	0.3	0.1	0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.7	-0.0	-0.4	-0.6	-0.1	-0.5	0.4	-0.2	0.5	0.1	-0.4	-0.0	0.1	-0.5	-0.8	-0.5	-0.5	0.1
Medication: Allopurinol	0.2	0.3	1.4	0.6	0.4	0.1	0.6	0.5	0.1	0.1	-0.0	0.7	0.5	0.6	-0.2	1.2	1.1	0.4	-0.1	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	1.4	-0.1	-0.1	0.5	0.0	-0.3	-0.7	-0.7	0.1	-0.8	0.0	-0.3	0.4	-1.2	-0.1	0.2	0.9	-0.1
Illnesses of siblings: Diabetes	0.2	0.2	1.8	0.3	0.2	0.4	0.3	0.2	0.1	-0.1	0.0	-0.1	0.9	0.2	1.4	0.3	0.4	0.7	0.3	0.2
Diabetes diagnosed by doctor	0.2	0.3	2.5	0.1	-0.3	-0.5	0.2	-0.3	-1.6	-0.9	0.4	-0.1	-0.4	-0.1	-0.5	0.1	0.4	-0.4	-0.3	0.3
Commuting to job workplace: Walk	0.2	0.3	0.6	-0.6	-0.4	-0.6	-0.5	-0.5	0.4	0.1	-0.1	-0.2	-0.6	-0.4	-0.8	-0.5	-0.5	-0.7	-0.8	-0.5
Medication: Gliclazide	0.2	0.3	2.4	0.2	-0.2	-0.2	0.1	-0.0	-1.5	-1.1	0.4	0.1	-0.3	0.1	-0.3	0.4	0.3	-0.2	-0.3	0.3
Irritability	0.2	0.3	0.9	-0.9	-0.0	-0.3	-0.9	-0.2	0.5	0.1	-0.9	-0.5	-0.3	0.3	0.1	-0.7	-0.9	-0.4	0.2	-0.8
Myopia	0.2	0.3	2.9	0.2	0.2	-0.4	0.1	0.1	0.7	0.0	0.2	-0.6	0.6	0.8	1.7	0.0	0.3	0.4	-0.0	0.2
Cholesterol lowering medication	0.2	0.2	1.3	0.4	0.3	0.3	0.4	0.5	-0.9	0.4	-0.2	0.6	-0.0	0.3	-0.4	1.1	0.7	-0.0	0.1	0.5
Bipolar Disorder or Schizophrenia	0.1	0.3	1.8	0.4	-0.1	-0.7	0.3	0.1	-0.4	-0.1	0.4	0.5	0.6	0.2	-0.3	1.3	0.6	-0.1	-1.4	0.3
Depressed Affect (Nagel 2018)	0.1	0.1	0.6	-0.3	0.4	-0.0	-0.2	0.4	-0.3	-0.0	-0.8	-0.0	0.4	0.1	0.6	0.1	-0.1	0.2	0.3	-0.3
Neuroticism (Nagel 2018)	0.1	0.2	0.8	-0.3	0.4	-0.2	-0.2	0.5	0.8	-0.2	-0.9	0.0	0.4	0.6	-0.1	0.5	0.3	0.5	0.3	-0.3
Triglycerides	0.1	0.2	1.0	0.1	-0.5	-1.0	-0.3	-0.4	-0.8	-0.4	0.5	0.0	-0.5	0.3	0.4	-0.1	-0.5	-0.3	-0.4	-0.1
Heel T-Score	0.1	0.9	4.2	0.2	1.1	1.2	0.4	1.0	-0.0	0.7	-0.5	0.1	0.7	1.3	1.8	0.3	0.8	0.9	2.1	0.4
Lung FVC	0.1	0.7	5.3	-0.1	-0.5	-0.2	-0.2	-0.7	1.1	-0.3	0.2	0.1	-0.6	-0.6	-0.1	-1.8	-2.3	-0.3	-0.9	-0.1
Chronotype (morning person)	0.1	0.2	1.0	0.3	-0.2	0.3	0.6	-0.1	-0.3	-0.4	0.6	0.0	0.4	0.3	-0.5	0.3	0.8	0.5	-1.0	0.4
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.5	-0.2	0.4	0.2	-0.1	0.4	-0.5	0.6	-0.6	0.1	0.2	0.7	-0.2	0.6	0.5	0.1	0.2	-0.1
Trunk fat percentage	0.1	0.6	2.2	1.2	-0.4	0.5	1.0	-0.3	-1.4	-0.7	1.5	0.7	-0.1	-0.3	0.1	0.2	0.1	0.2	-0.1	1.1
Fed-up feelings	0.1	0.1	0.8	-0.1	0.0	-0.1	-0.2	0.1	-0.9	-0.3	-0.2	0.0	0.2	-0.3	0.5	-0.1	-0.3	-0.1	-0.4	-0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	1.7	0.0	-0.5	-0.6	-0.1	-0.4	-1.3	-0.5	0.6	-0.4	-0.2	-0.3	0.2	-0.1	-0.3	-0.6	0.3	0.0
High blood pressure	0.1	0.4	2.0	0.2	0.4	0.0	0.3	0.5	-1.0	-0.1	-0.5	0.5	0.6	0.4	-0.9	1.2	1.4	0.2	-0.2	0.3
Neuroticism score	0.1	0.3	1.0	-0.9	-0.0	-0.7	-0.9	-0.0	0.3	-0.3	-1.0	-0.5	0.1	0.7	0.1	-0.1	-0.4	-0.4	-0.3	-0.9
Time employed in main current job	0.1	0.2	0.6	0.5	0.2	0.3	0.5	0.3	-0.0	-0.5	-0.3	0.5	0.2	0.7	0.0	0.5	0.3	0.3	-0.4	0.4
Prospective memory result	0.1	0.2	0.6	-0.6	0.0	-0.3	-0.5	0.3	0.7	-0.3	-0.7	-0.2	-0.1	0.0	-0.7	0.3	-0.1	0.1	-0.0	-0.8
Emphysema/chronic bronchitis	0.1	0.1	0.4	0.6	0.1	0.1	0.4	0.2	-0.0	-0.1	0.4	0.4	0.0	-0.2	0.6	-0.0	-0.0	0.3	0.6	0.4
Migraine (self-reported)	0.1	0.2	1.1	-0.2	-0.3	-0.4	-0.2	-0.0	-0.3	-0.6	-0.1	-0.1	-0.0	-0.5	-0.6	0.5	0.2	-0.3	-1.1	-0.3
Alcohol intake frequency.	0.1	0.2	0.5	-0.4	-0.3	-0.1	-0.4	-0.4	0.0	-0.4	0.1	-0.3	-0.1	-0.5	-0.5	-0.7	-0.6	-0.1	-0.7	-0.4
Medication: Aspirin	0.1	0.1	0.8	0.1	0.1	0.1	0.1	0.2	-0.9	-0.2	0.4	0.2	-0.1	-0.1	-0.2	0.4	0.4	-0.3	0.6	0.4
Hypertension (Self-reported)	0.1	0.3	1.6	0.2	0.4	0.1	0.4	0.5	-1.1	-0.2	-0.4	0.4	0.5	0.4	-0.8	1.0	1.3	0.2	0.2	0.3
Medication: Aspirin	0.1	0.1	1.0	0.0	0.2	0.2	0.1	0.2	-1.0	-0.2	0.0	0.2	-0.0	0.1	-0.4	0.5	0.5	-0.2	0.8	0.2
Miserableness	0.1	0.1	0.8	-0.6	0.2	-0.4	-0.5	0.2	0.1	0.1	-0.9	-0.1	0.2	0.4	0.3	0.2	-0.4	-0.1	0.3	-0.6
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.5	-0.6	-0.2	-0.3	-0.5	-0.2	0.2	-0.1	-0.6	-0.5	0.0	-0.3	-0.3	-0.3	-0.3	-0.1	-0.5	-0.7

Hub : Genes

MAPRE1

Models

Trait associations