TWAS hub - PIGU

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.0494	0.0250	0.00028	0.055	NA	0.039	NA	0.044	4.0e-05	NA	5.0e-04	NA	2.2e-04
2	GTEx	Cells Transformed fibroblasts	0.0610	0.0330	0.00570	-0.002	NA	0.017	NA	0.005	5.1e-01	NA	1.8e-02	NA	1.3e-01
3	GTEx	Colon Sigmoid	0.1320	0.0700	0.00058	0.090	NA	0.116	NA	0.104	4.3e-04	NA	6.9e-05	NA	1.6e-04
4	GTEx	Testis	0.3800	0.0760	0.00000	0.483	NA	0.457	NA	0.474	4.7e-24	NA	2.3e-22	NA	1.9e-23
5	TCGA	Brain Lower Grade Glioma	0.0328	0.0236	0.00310	0.023	0.018	0.002	NA	0.016	1.0e-03	0.00370	2.0e-01	NA	4.9e-03
6	TCGA	Testicular Germ Cell Tumors	0.1010	0.0620	0.00120	0.099	0.079	0.093	NA	0.096	2.3e-04	0.00097	3.5e-04	NA	2.8e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	3	4	5	6
Tanning	16.4	199.7	515.3	-13.7	8.8	-14.2	-22.7	-14.7
Hair Pigment	10.2	292.3	731.3	17.1	-8.7	18.0	27.0	18.1
Hand grip strength (right)	8.0	21.8	32.8	5.4	4.4	5.5	4.4	5.7
Heel T-Score	7.7	60.9	81.4	8.9	8.1	9.0	7.8	8.8
Hand grip strength (left)	7.7	20.3	28.8	5.2	4.4	5.2	4.2	5.4
Peak expiratory flow (PEF)	7.4	17.2	24.5	4.9	3.5	5.0	4.4	4.8
Hearing difficulty/problems with background noise	7.0	11.2	14.9	3.6	3.5	3.6	3.7	3.9
Sitting height	6.8	48.5	77.1	7.8	8.8	7.8	4.9	8.3
Hair/balding pattern: Pattern 4	6.8	16.5	24.9	4.4	5.0	4.4	3.9	4.5
Basal cell carcinoma (self-reported)	6.7	8.0	14.9	3.0	0.3	3.2	3.9	3.7
Neck or shoulder pain in last month	6.5	9.2	13.0	3.2	3.3	3.3	3.1	3.6
Vitamin and mineral supplements	6.3	8.5	13.0	-3.1	-3.4	-3.0	-2.7	-3.6
Tinnitus: Yes, now most or all of the time	6.0	7.0	10.4	3.2	2.2	3.2	3.1	2.7
Height	5.8	112.1	179.6	11.5	11.3	12.1	9.3	13.4
Standing height	5.5	54.4	84.9	8.1	8.3	8.3	6.2	9.2
Reaction Time	5.1	9.6	13.6	-3.2	-3.2	-3.5	-3.4	-3.7
Worry (Nagel 2018)	5.0	10.6	15.8	3.8	2.5	3.8	4.0	3.6
Lung FEV1/FVC ratio	4.9	24.6	35.2	5.9	5.3	5.8	4.9	5.1
Severe depression (siblings)	4.7	5.2	9.0	2.5	3.0	2.5	1.8	2.6
Depression (self-reported)	4.4	5.3	8.1	-2.8	-2.0	-2.8	-2.2	-2.6
Multivitamins +/- minerals	4.3	5.5	8.1	2.6	2.9	2.5	2.0	2.8
Supplements: Glucosamine	4.3	5.7	10.0	2.5	2.6	2.5	2.2	3.2
Trunk fat-free mass	4.2	24.4	46.4	5.5	6.8	5.3	3.1	5.7
Trunk predicted mass	4.0	23.1	44.8	5.3	6.7	5.1	3.0	5.5
Allergy or Eczema	3.9	10.3	14.0	3.7	3.1	3.7	3.2	3.7
Ulcerative Colitis (UC)	3.8	7.2	10.9	2.6	2.9	2.9	2.9	3.3
Fasting Glucose	3.8	4.6	6.8	2.5	2.0	2.5	2.0	2.6
Allergy	3.6	8.2	14.1	-3.1	-3.8	-3.0	-2.7	-3.1
Illnesses of siblings: Diabetes	3.5	4.3	5.6	2.2	2.4	2.2	2.2	2.3
Worrier / anxious feelings	3.4	6.4	9.4	3.1	1.9	2.9	3.0	2.8
Arm fat-free mass (right)	3.4	17.4	36.7	4.7	6.1	4.4	2.2	4.7
Whole body fat-free mass	3.4	19.2	39.2	4.8	6.3	4.6	2.5	4.9
Pain type(s) experienced in last month: Hip pain	3.4	4.3	6.0	2.2	2.4	2.2	2.1	2.5
Irritability	3.3	5.6	13.9	2.5	0.6	2.6	3.7	2.5
Arm predicted mass (left)	3.3	16.6	37.6	4.4	6.1	4.2	2.1	4.5
Nervous feelings	3.2	5.9	11.0	2.8	1.5	2.8	3.3	2.7
Illnesses of siblings	3.2	4.5	5.9	-2.3	-2.4	-2.4	-2.1	-2.4
Hair/balding pattern: Pattern 3	3.2	4.7	9.5	3.1	1.9	2.7	1.8	2.2
Whole body water mass	3.2	18.3	37.2	4.7	6.1	4.5	2.4	4.8
Arm fat-free mass (left)	3.2	16.3	34.2	4.5	5.8	4.2	2.2	4.6
Type 2 Diabetes (T2D) (2012)	3.0	3.4	4.9	2.1	2.2	2.0	1.6	2.1
Past tobacco smoking	3.0	5.6	10.5	2.9	3.2	2.7	1.7	2.1
Smoking status: Previous	3.0	4.4	7.3	-2.6	-2.7	-2.5	-1.7	-1.9
Basal metabolic rate	3.0	16.7	34.5	4.5	5.9	4.3	2.3	4.6
Hayfever, allergic rhinitis or eczema	2.9	6.2	8.6	2.7	2.9	2.7	2.4	2.9
Age started oral contraceptive pill	2.9	3.7	5.9	1.9	2.1	2.0	2.0	2.4
Pack years of smoking	2.9	4.3	6.1	2.3	2.1	2.4	2.1	2.5
Number of incorrect matches in round	2.8	4.7	8.0	-2.8	-1.9	-2.7	-2.3	-2.1
Arm predicted mass (right)	2.8	14.1	31.2	4.2	5.6	3.9	1.7	4.2
Age at First Birth	2.7	4.0	5.3	2.1	2.2	2.2	2.3	2.2
HDL Cholesterol	2.7	4.4	6.5	-2.6	-2.3	-2.4	-1.6	-2.5
Ulcerative Colitis	2.7	3.9	5.7	2.0	2.1	2.1	2.2	2.4
Mouth/teeth dental problems	2.7	4.1	6.0	2.2	1.9	2.2	2.5	2.2
Worry too long after embarrassment	2.7	4.6	8.7	2.5	0.6	2.5	2.9	2.5
Mean time to correctly identify matches	2.7	5.1	6.7	-2.4	-2.3	-2.6	-2.5	-2.6
Reason for reducing amount of alcohol drunk: Health precaution	2.6	3.0	4.9	1.7	2.1	1.7	1.7	2.2
Comparative height size at age 10	2.6	14.2	24.9	4.3	3.3	4.6	3.2	5.0
Average weekly red wine intake	2.6	3.8	9.2	1.7	3.0	1.8	1.8	2.1
Smoking Status	2.5	6.0	10.5	-3.2	-2.5	-3.1	-2.0	-2.4
Heel bone mineral density (BMD) T-score, automated (right)	2.5	5.8	9.1	2.7	3.0	2.7	1.9	2.6
Lung cancer (father)	2.5	2.9	6.1	1.4	2.5	1.6	1.8	1.9
Mineral and other dietary supplements	2.5	3.4	5.4	-1.8	-2.3	-1.7	-1.8	-2.3
Supplements: Fish oil (including cod liver oil)	2.5	3.2	5.3	2.0	2.3	1.8	1.7	2.0
Leg fat-free mass (left)	2.4	12.7	27.2	4.0	5.2	3.8	1.9	3.9
Health satisfaction	2.4	3.2	7.6	1.9	2.8	1.8	1.5	1.5
Blood Red Count	2.3	22.0	31.7	5.5	3.4	5.6	5.6	5.2
Ever used hormone-replacement therapy (HRT)	2.3	2.9	3.9	1.9	1.7	1.9	1.8	2.0
Qualifications: CSEs or equivalent	2.3	3.1	4.5	-2.0	-2.1	-2.1	-1.6	-1.8
Leg predicted mass (left)	2.3	12.3	26.4	3.9	5.1	3.7	1.9	3.8
Hayfever/allergic rhinitis (self-reported)	2.3	3.1	5.1	2.3	1.6	2.2	1.7	1.8
Tense / ‘highly strung’	2.3	3.9	7.7	2.1	0.8	2.3	2.8	2.3
Qualifications: College or University degree	2.3	7.3	14.0	2.6	3.7	2.9	2.5	3.0
Illnesses of father: High blood pressure	2.3	2.8	4.3	-2.0	-1.2	-2.0	-2.1	-1.8
Average weekly fortified wine intake	2.2	2.6	4.1	1.6	1.5	1.8	2.0	1.8
Primary Biliary Cirrhosis	2.1	2.9	5.0	-2.1	-0.6	-2.2	-2.2	-1.8
Respiratory disease	2.1	4.8	9.3	2.4	3.0	2.2	2.2	2.0
Hearing difficulty/problems: Yes	2.1	3.1	5.4	1.6	1.6	1.9	2.3	2.2
Heel bone mineral density (BMD) T-score, automated (left)	2.0	4.5	7.7	2.5	2.8	2.5	1.5	2.2
Hypertension (Self-reported)	2.0	5.7	8.4	-2.4	-2.4	-2.5	-2.7	-2.9
Leg fat-free mass (right)	2.0	10.7	25.0	3.6	5.0	3.4	1.6	3.5
Leg predicted mass (right)	2.0	10.7	24.6	3.6	5.0	3.4	1.6	3.5
Bilateral oophorectomy (both ovaries removed)	1.9	2.1	3.4	-1.1	-1.8	-1.4	-1.7	-1.8
Breastfed as a baby	1.9	2.4	6.6	-1.8	-2.6	-1.6	-1.0	-1.1
Long-standing illness, disability or infirmity	1.9	2.9	6.4	1.8	2.5	1.6	1.2	1.9
Neuroticism (Nagel 2018)	1.8	4.3	7.9	2.3	1.5	2.4	2.8	2.1
Lung FVC	1.8	9.3	29.7	-3.2	-5.5	-2.7	-1.4	-2.6
High blood pressure	1.8	5.0	7.6	-2.3	-2.2	-2.4	-2.7	-2.7
Chest pain or discomfort	1.8	2.6	3.9	1.8	1.8	1.8	1.4	2.0
Blood Platelet Count	1.7	19.1	28.5	4.8	5.3	4.5	4.7	4.7
Neuroticism	1.7	4.1	7.6	2.0	1.2	2.2	2.8	2.5
Diabetes (father)	1.7	2.1	4.0	-1.5	0.6	-1.8	-2.0	-1.7
Pack years adult smoking proportion	1.7	2.5	3.7	1.7	1.8	1.8	1.5	1.9
Qualifications: A levels/AS levels or equivalent	1.7	3.7	6.6	2.1	1.3	2.4	1.9	2.6
Pulse wave Arterial Stiffness index	1.7	1.9	3.1	1.8	1.5	1.6	1.3	1.4
Medication: Amlodipine	1.7	2.4	4.3	-1.5	-1.3	-1.8	-1.7	-2.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.7	2.0	3.4	-1.8	-0.9	-1.8	-1.5	-1.5
Wears glasses or contact lenses	1.7	2.0	2.8	1.6	1.4	1.7	1.6	1.4
Heart disease (siblings)	1.7	2.1	3.2	1.8	1.0	1.8	1.5	1.8
Rheumatoid Arthritis	1.6	2.2	6.1	-1.3	-2.5	-1.3	-1.0	-1.7
Current tobacco smoking	1.6	2.6	5.0	-2.2	-1.4	-2.0	-1.3	-1.7
Fluid intelligence score	1.6	3.2	7.3	1.8	0.8	2.1	1.9	2.7
Weight	1.6	8.0	17.0	3.2	4.1	3.0	1.4	3.0
Qualifications: NVQ or HND or HNC or equivalent	1.6	1.9	3.0	-1.6	-1.7	-1.6	-1.3	-1.4
Ever smoked	1.6	2.9	4.9	-2.2	-2.2	-2.0	-1.2	-1.4
Verbal and Numeric Reasoning (VNR)	1.5	3.5	7.1	1.9	1.2	2.3	1.9	2.7
Chronotype (morning person)	1.5	3.5	5.0	2.2	2.2	2.1	1.8	1.8
Pulse wave reflection index	1.5	1.9	5.7	1.2	2.4	1.1	0.9	1.4
Forced expiratory volume in 1-second (FEV1), predicted	1.5	3.1	5.6	1.9	2.4	2.0	1.1	1.9
Schizophrenia (2018)	1.4	2.9	6.8	1.8	2.6	1.7	1.5	1.6
HbA1C	1.4	1.5	2.7	-1.1	-1.6	-1.2	-1.6	-1.1
Systolic blood pressure, automated reading	1.4	4.2	8.9	2.2	3.0	2.1	1.5	2.2
Qualifications: None of the above	1.4	3.0	5.0	-1.6	-2.1	-1.8	-1.8	-2.2
Prospective memory result	1.4	1.7	2.9	-1.4	0.4	-1.5	-1.7	-1.6
Mouth/teeth dental problems: Bleeding gums	1.4	1.8	4.4	-1.3	-2.1	-1.2	-1.2	-1.4
Friendships satisfaction	1.4	1.7	2.7	-1.5	0.3	-1.6	-1.6	-1.6
Medication: Blood pressure	1.3	2.3	3.6	-1.6	-1.0	-1.8	-1.9	-1.9
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	3.0	1.5	0.7	1.6	1.2	1.7
Medication: Gliclazide	1.3	1.5	2.3	1.5	1.5	1.4	1.1	1.1
Illnesses of father: None of the above (group 1)	1.3	1.6	2.7	1.2	0.8	1.5	1.6	1.6
Medication: Bendroflumethiazide	1.3	1.9	2.8	-1.4	-1.6	-1.4	-1.5	-1.7
Medication: Lisinopril	1.3	1.6	2.7	-1.4	-0.8	-1.5	-1.6	-1.4
Vascular/heart problems diagnosed by doctor	1.3	3.5	5.4	1.9	1.8	2.0	2.3	2.2
Townsend deprivation index at recruitment	1.2	1.7	6.3	-1.0	-2.5	-0.9	-0.7	-1.2
Eye problems/disorders: None of the above	1.2	1.4	2.3	-1.4	-1.0	-1.5	-1.1	-1.4
Eye problems/disorders: Cataract	1.2	1.4	3.8	1.2	2.0	1.1	0.7	1.2
Back pain experienced in last month	1.2	1.8	2.9	1.3	1.3	1.4	1.7	1.6
Osteoarthritis (self-reported)	1.2	1.6	2.8	1.4	1.7	1.2	1.3	1.2
Smoking status: Current	1.2	1.9	3.8	-2.0	-1.2	-1.7	-0.9	-1.4
Pain experienced in last month	1.2	1.9	2.8	-1.6	-1.1	-1.6	-1.7	-1.6
Had menopause	1.1	1.3	3.1	1.0	1.2	1.1	1.2	1.8
Alcohol intake versus 10 years previously	1.1	1.6	2.8	1.7	0.7	1.6	1.4	1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.4	2.2	-1.5	-0.6	-1.5	-1.4	-1.2
Heart disease (mother)	1.1	1.4	2.7	1.6	0.4	1.6	1.1	1.2
Bipolar Disorder or Schizophrenia	1.0	2.4	7.7	1.7	2.8	1.5	0.7	1.2
Alzheimer’s Disease (in father)	1.0	1.1	2.0	-0.8	-0.8	-1.1	-1.3	-1.4
Bipolar Disorder (2011)	1.0	0.9	2.9	1.2	1.7	1.0	0.1	0.7
Blood White Count	1.0	7.2	10.8	3.2	3.3	2.9	2.3	2.9
Noisy workplace	1.0	1.2	1.7	-1.3	-1.2	-1.2	-1.0	-1.3
Had major operations	1.0	1.2	3.5	-0.7	-1.9	-0.9	-1.0	-1.3
Ever had bowel cancer screening	1.0	1.1	2.4	0.8	1.6	1.1	1.0	1.3
Commuting to job workplace: Walk	1.0	1.1	1.9	1.4	0.5	1.2	1.1	1.3
Eye problems/disorders: Glaucoma	1.0	1.2	1.9	-1.3	-0.9	-1.2	-1.2	-1.4
Alcohol drinker status: Previous	1.0	1.1	1.9	1.4	1.0	1.2	1.0	1.2
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.5	2.6	1.4	1.6	1.4	0.9	1.3
Falls in the last year	0.9	1.2	2.3	1.1	1.5	1.1	1.0	1.1
Asthma	0.9	1.8	2.7	1.6	1.6	1.5	1.4	1.3
Age at first live birth	0.9	1.6	3.0	1.7	0.7	1.6	1.2	1.5
Medication: Aspirin	0.9	1.2	2.6	1.6	1.3	1.3	0.9	0.7
Irritable Bowel Disease (IBD)	0.8	1.8	2.8	1.4	1.1	1.7	1.5	1.7
Major Depression (MDD)	0.8	1.0	1.6	1.3	0.9	1.1	1.0	1.0
Breast Cancer	0.8	1.9	3.7	-1.3	-1.0	-1.5	-1.9	-1.7
Chronic bronchitis/emphysema (father)	0.8	0.9	1.3	-1.1	-1.1	-1.0	-0.9	-1.1
Had other major operations	0.8	1.0	1.7	1.2	-0.6	1.3	1.0	1.1
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	2.1	0.8	0.4	1.0	1.4	1.5
Neuroticism score	0.8	1.6	4.0	1.2	-0.1	1.4	2.0	1.5
Forced expiratory volume in 1-second (FEV1)	0.8	2.7	4.5	1.9	0.8	2.1	1.9	2.0
Angina (self-reported)	0.8	1.0	2.3	1.3	1.5	1.1	0.4	1.0
Migraine (self-reported)	0.8	0.9	2.2	-1.2	-1.5	-0.8	-0.9	-0.8
Medication: Aspirin	0.8	1.0	2.0	1.4	1.3	1.2	0.8	0.4
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	3.7	0.9	1.9	0.8	0.1	0.8
LDL Cholesterol	0.7	1.2	2.1	-1.2	-1.4	-1.0	-1.4	-0.8
Pulse rate	0.7	1.2	3.2	-0.7	-1.8	-0.9	-1.0	-1.3
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.2	-1.0	-0.7	-1.0	-1.0	-1.1
Length of working week for main job	0.7	0.8	1.6	-0.9	-0.4	-1.1	-1.3	-0.9
Blood clot in the leg (DVT)	0.7	0.9	3.3	0.9	1.8	0.8	0.1	0.7
Glaucoma (self-reported)	0.7	0.8	1.4	-1.2	-0.4	-1.0	-1.1	-1.1
Pulse rate, automated reading	0.7	2.4	6.8	-1.0	-2.6	-1.2	-1.2	-2.0
Suffer from ‘nerves’	0.7	1.1	2.0	0.9	0.8	1.1	1.3	1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	1.7	0.8	0.9	0.9	1.3	0.8
Mouth/teeth dental problems: Mouth ulcers	0.7	1.0	1.9	-1.4	-0.7	-1.2	-1.0	-1.1
Asthma (self-reported)	0.7	1.4	2.1	1.4	1.4	1.3	1.3	1.1
Risk taking	0.7	1.0	3.3	0.9	1.8	0.9	0.5	1.0
Prostate Cancer	0.6	0.9	2.4	-0.9	-1.5	-0.9	-0.7	-1.0
Neuroticism (2016)	0.6	0.8	1.6	0.9	0.7	1.0	1.3	0.9
Number of treatments/medications taken	0.6	1.1	1.6	1.3	0.9	1.3	0.9	1.2
Pain all over the body in last month	0.6	0.6	1.5	1.0	0.4	1.0	0.5	1.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	2.0	3.6	1.5	1.0	1.8	1.5	1.9
Birth weight	0.6	1.3	2.8	0.8	1.0	1.1	1.4	1.7
Shortness of breath walking on level ground	0.6	0.7	1.3	-1.0	-0.8	-0.9	-0.7	-1.1
Overall health rating	0.6	1.3	2.1	1.5	1.3	1.3	1.0	1.0
Loneliness, isolation	0.6	0.8	1.7	-0.8	-1.0	-0.8	-0.8	-1.3
Ever depressed for a whole week	0.6	0.7	1.4	0.6	1.2	0.7	1.1	0.9
Myopia	0.6	0.9	4.2	0.6	2.0	0.4	0.6	0.6
Alzheimer’s Disease (including proxy)	0.5	0.7	1.0	-1.0	-0.9	-0.9	-1.0	-0.9
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.3	-1.1	-0.5	-1.2	-0.8	-0.8
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	1.4	0.4	-0.3	0.8	1.2	1.2
Maternal smoking around birth	0.5	0.7	1.3	-1.0	-0.9	-1.0	-0.5	-1.1
Relative age voice broke	0.5	0.7	2.4	0.7	-0.7	0.8	1.6	0.6
Trunk fat mass	0.5	2.1	4.3	1.7	2.1	1.6	0.8	1.6
Financial difficulties in last 2 years	0.5	0.7	1.4	-1.0	-0.1	-1.2	-0.8	-1.1
Mouth/teeth dental problems: Dentures	0.5	0.8	2.4	-0.7	-0.7	-0.9	-1.5	-0.9
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	1.6	1.0	0.6	1.1	1.2	1.3
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.0	-0.8	0.5	-1.0	-0.7	-1.0
High blood pressure (siblings)	0.5	0.8	1.5	1.0	1.2	1.0	0.5	0.9
Comparative body size at age 10	0.5	1.5	3.9	-0.9	-0.8	-1.2	-2.0	-1.4
Pulse wave peak to peak time	0.5	0.5	1.0	-1.0	-1.0	-0.8	-0.7	-0.5
Medication: Seretide 50 evohaler	0.5	0.6	1.2	-0.9	-0.0	-0.9	-1.1	-0.9
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.1	-0.8	0.2	-1.0	-1.1	-0.8
Illnesses of father: Heart disease	0.5	0.8	1.6	1.0	0.4	1.1	0.8	1.3
Number of self-reported non-cancer illnesses	0.5	0.9	1.6	1.0	1.2	0.9	0.9	1.0
Financial situation satisfaction	0.5	0.6	1.4	-1.2	-0.5	-1.1	-0.5	-0.9
Medication: Blood pressure	0.5	1.0	2.0	-0.8	-1.4	-0.8	-1.2	-1.2
Unable to work because of sickness or disability	0.5	0.7	1.6	-0.6	-1.3	-0.8	-0.7	-1.1
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.2	1.0	0.2	1.1	0.8	0.8
Supplements: Calcium	0.5	0.5	1.1	-0.9	-0.4	-0.9	-1.0	-0.3
Schizophrenia (2014)	0.4	0.8	3.1	0.8	1.8	0.8	0.4	0.5
Relative age of first facial hair	0.4	0.9	4.2	-0.5	-2.0	-0.4	0.4	-0.7
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.1	1.0	0.3	0.8	0.7	0.4
Angina	0.4	0.6	1.3	1.1	1.1	0.8	0.2	0.7
Medication for hormone replacement therapy	0.4	0.5	0.8	0.9	0.2	0.8	0.7	0.8
Fed-up feelings	0.4	0.7	1.3	-0.7	-1.1	-0.7	-0.9	-1.1
Serious illness, injury or assault to yourself	0.4	0.5	0.8	-0.8	-0.5	-0.9	-0.7	-0.8
Hip circumference	0.4	1.8	6.2	1.4	2.5	1.1	-0.0	1.1
Exposure to tobacco smoke at home	0.4	0.5	1.1	0.9	-0.3	0.8	1.1	0.4
Wheeze or whistling in the chest in last year	0.4	0.7	3.4	0.5	1.8	0.3	0.4	0.3
Medication: Ibuprofen	0.4	0.4	0.9	0.9	0.2	0.9	0.6	0.7
Medication: Omeprazole	0.4	0.5	0.7	0.7	0.6	0.8	0.7	0.9
Whole body fat mass	0.4	1.5	3.7	1.5	1.9	1.3	0.4	1.2
Age at last live birth	0.4	0.6	1.0	0.9	0.5	1.0	0.8	0.8
Supplements: Vitamin C	0.4	0.5	1.4	0.7	1.2	0.5	0.2	0.8
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.4	0.7	1.2	0.6	0.6	0.6
Diabetes diagnosed by doctor	0.4	0.6	2.9	0.0	1.7	-0.3	-0.7	-0.4
Osteoporosis (self-reported)	0.4	0.5	1.2	-0.6	-1.1	-0.7	-0.7	-0.5
Alcohol drinker status: Never	0.4	0.5	1.1	-0.6	-0.5	-0.7	-0.9	-1.1
Average weekly beer plus cider intake	0.4	0.6	1.5	-1.2	-0.2	-1.2	-0.7	-0.6
Type 2 Diabetes (T2D) (2018)	0.3	0.6	2.7	0.2	1.6	-0.3	-0.8	-0.5
Age when periods started (menarche)	0.3	0.7	1.5	0.4	1.2	0.6	1.2	0.9
High blood pressure (mother)	0.3	0.4	1.8	0.5	1.3	0.4	-0.3	0.0
Alcohol usually taken with meals	0.3	0.5	1.2	-0.7	0.5	-0.8	-1.1	-0.8
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	1.0	0.7	0.2	0.6	1.0	0.9
Hair/balding pattern: Pattern 2	0.3	0.4	1.2	-0.4	-1.1	-0.0	0.6	0.7
Diabetes (self-reported)	0.3	0.5	2.8	0.2	1.7	-0.1	-0.4	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.3	0.7	0.8	-0.0	0.7	0.6	0.7
Impedance of arm (left)	0.3	1.4	6.9	-0.7	-2.6	-0.3	1.1	-0.2
Arm fat mass (right)	0.3	1.3	3.7	1.4	1.9	1.1	0.2	0.9
Number of children fathered	0.3	0.3	0.7	0.8	0.4	0.7	0.6	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.5	0.8	-0.0	1.0	1.2	0.7
Arm fat mass (left)	0.3	1.2	3.2	1.4	1.8	1.1	0.2	0.9
Hearing aid user	0.3	0.3	0.6	0.5	0.6	0.6	0.5	0.8
Cholesterol lowering medication	0.3	0.4	0.9	0.9	0.9	0.9	0.3	0.4
Bipolar Disorder (2018)	0.2	0.4	1.4	0.5	1.2	0.2	-0.8	0.0
Depression (Nagel 2018)	0.2	0.3	1.3	0.2	1.1	0.2	0.4	0.5
Intelligence (Savage-Jansen 2018)	0.2	0.8	2.4	0.6	0.2	1.0	0.8	1.6
Alzheimer’s Disease (in mother)	0.2	0.3	0.7	0.3	0.1	0.6	0.6	0.9
Crohns Disease (2017)	0.2	0.4	1.2	-0.6	-1.1	-0.4	-0.5	-0.7
Ovarian Cancer	0.2	0.3	0.7	-0.4	-0.3	-0.5	-0.7	-0.8
Body Mass Index (BMI) (2010)	0.2	0.3	1.4	-0.0	1.2	-0.1	-0.8	0.0
Coronary Artery Disease (CAD)	0.2	0.3	0.5	0.6	0.7	0.5	0.0	0.7
Mean Putamen Volume	0.2	0.2	0.8	0.2	0.7	-0.0	-0.9	-0.2
Blood Eosinophil Count	0.2	1.5	3.4	1.8	0.7	1.6	1.3	1.0
Waist Hip Ratio (WHR)	0.2	1.0	4.2	-0.6	-2.1	-0.6	0.1	-0.9
Diabetes (mother)	0.2	0.3	1.3	0.0	1.2	0.1	-0.2	0.5
Stomach or abdominal pain in last month	0.2	0.2	0.6	0.1	0.5	0.4	0.6	0.8
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	0.6	0.3	0.8	0.4	0.7	0.6
Impedance of leg (left)	0.2	1.1	3.8	-1.3	-1.9	-0.9	0.3	-0.4
Forced vital capacity (FVC)	0.2	0.9	2.3	0.7	-0.1	1.1	1.1	1.5
Heart attack	0.2	0.3	0.7	0.5	0.3	0.6	0.4	0.9
Impedance of arm (right)	0.2	1.0	3.2	-0.3	-1.8	0.0	1.6	0.1
Gout (self-reported)	0.2	0.3	0.7	0.8	0.1	0.6	0.5	0.5
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.6	-0.5	-0.1	-0.6	-0.6	-0.8
Forced vital capacity (FVC), Best measure	0.2	0.9	2.4	0.8	0.1	1.1	1.0	1.6
Leg fat mass (right)	0.2	0.9	3.8	0.9	2.0	0.6	-0.1	0.5
Family relationship satisfaction	0.2	0.2	0.9	-0.3	0.9	-0.3	-0.2	-0.3
Knee pain experienced in last month	0.2	0.3	1.2	0.6	0.1	0.5	1.1	0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.8	-0.9	-0.3	-0.5	-0.2	-0.1
Medication for cholesterol	0.2	0.2	0.5	-0.6	0.5	-0.7	-0.5	-0.3
Miserableness	0.2	0.3	0.6	-0.7	-0.8	-0.6	-0.3	-0.5
Commuting to job workplace: Public transport	0.2	0.2	0.7	0.0	-0.3	0.3	0.5	0.8
Leg fat percentage (left)	0.2	0.7	1.3	-0.8	0.2	-0.9	-1.1	-1.1
Number of operations (self-reported)	0.2	0.3	1.7	0.0	-1.3	0.0	-0.0	-0.3
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.5	-0.3	0.7	0.2	0.5	0.6
Fractured/broken bones in last 5 years	0.2	0.2	0.4	-0.6	-0.4	-0.6	-0.4	-0.5
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.8	0.5	0.4	0.6	0.4	0.9
Impedance of whole body	0.2	1.3	5.7	-0.8	-2.4	-0.4	1.0	-0.1
Leg fat mass (left)	0.2	0.9	4.0	0.9	2.0	0.7	-0.1	0.6
Schizophrenia vs Biploar Disorder	0.1	0.2	0.7	0.2	0.3	0.4	0.8	0.4
Lupus	0.1	0.2	1.0	-0.0	1.0	0.1	0.0	0.4
Triglycerides	0.1	0.2	0.9	0.3	-0.3	0.3	-1.0	0.2
BMI	0.1	0.6	1.9	-0.1	0.6	-0.5	-1.4	-0.9
Systolic Blood Pressure	0.1	0.3	0.7	0.8	0.7	0.7	0.3	0.6
Cardiovascular Disease	0.1	0.4	1.0	-0.3	-0.7	-0.4	-1.0	-0.9
Average weekly spirits intake	0.1	0.1	0.2	0.3	0.2	0.3	0.4	0.5
Ever had hysterectomy (womb removed)	0.1	0.1	0.2	0.5	-0.4	0.4	0.0	0.1
Supplements: Zinc	0.1	0.1	0.2	0.3	0.5	0.2	-0.3	0.3
Medication: Co-codamol	0.1	0.1	0.4	0.1	-0.4	0.3	0.6	0.4
Medication: Metformin	0.1	0.2	0.6	0.1	-0.1	-0.3	-0.7	-0.8
Impedance of leg (right)	0.1	0.5	2.2	-0.4	-1.5	-0.2	0.9	0.2
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.5	-0.2	-0.7	-0.1	-0.1	-0.2
Body mass index (BMI)	0.1	0.4	1.4	-0.1	0.7	-0.4	-1.2	-0.8
Waist circumference	0.1	0.3	1.1	0.6	1.0	0.4	-0.2	0.3
Medication: Ramipril	0.1	0.2	0.7	0.2	0.9	0.2	0.3	0.2
Medication: Simvastatin	0.1	0.2	0.4	0.1	0.5	-0.2	-0.6	-0.6
Time employed in main current job	0.1	0.1	0.6	0.1	0.8	0.0	0.1	0.4
Father’s age at death	0.1	0.2	0.9	-0.1	0.9	-0.3	0.1	-0.5
Number of live births	0.1	0.2	0.5	-0.7	-0.1	-0.6	-0.4	-0.4
Happiness	0.1	0.1	0.7	-0.0	0.8	0.1	0.3	0.1
Medication: Lansoprazole	0.1	0.1	0.3	0.2	-0.1	0.3	0.6	0.5
Illnesses of mother	0.1	0.1	0.3	-0.5	-0.4	-0.5	-0.1	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.5	-0.7	0.0	-0.5	-0.6	0.1
Birth weight of first child	0.1	0.1	0.2	0.4	0.3	0.4	0.4	0.0
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.3	-0.1	-0.3	-0.1	0.5	0.0
Loud music exposure frequency	0.1	0.1	0.5	0.0	-0.7	0.1	0.4	0.2
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.2	-0.5	0.4	-0.1	-0.3	0.5
Medication: Paracetamol	0.1	0.2	0.5	0.0	-0.6	-0.2	-0.7	-0.5
Headache pain in last month	0.1	0.2	0.4	0.4	-0.5	0.6	0.5	0.2
Leg fat percentage (right)	0.1	0.5	0.9	-0.6	0.3	-0.8	-0.9	-1.0
Exposure to tobacco smoke outside home	0.1	0.1	0.4	0.1	-0.6	0.1	0.5	0.2
Number of full brothers	0.1	0.1	0.4	0.3	0.7	0.4	0.2	0.3
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.7	0.2	0.8	0.3	-0.1	0.1
Emphysema/chronic bronchitis	0.1	0.1	0.3	-0.6	-0.2	-0.5	-0.0	-0.1
Medication for pain relief, constipation, heartburn	0.1	0.2	0.8	-0.9	0.0	-0.7	-0.2	-0.3
Medication: Allopurinol	0.1	0.1	0.3	0.5	0.5	0.3	0.2	0.3
Alcohol intake frequency.	0.1	0.3	1.1	0.3	-1.0	0.4	0.5	0.0
Leg pain on walking	0.1	0.1	0.2	0.0	0.3	0.1	0.5	0.2
Arm fat percentage (left)	0.1	0.2	0.7	-0.2	-0.3	-0.4	-0.6	-0.8
Mood swings	0.1	0.1	0.4	-0.2	-0.6	-0.1	0.2	-0.2
Qualifications: nursing, teaching	0.1	0.2	0.4	0.3	0.6	0.4	0.5	0.4
Breast cancer (self-reported)	0.1	0.1	0.5	-0.3	-0.7	-0.0	0.2	0.0
Average weekly champagne plus white wine intake	0.1	0.1	0.4	0.4	0.7	0.2	0.2	0.4
Guilty feelings	0.1	0.2	0.5	-0.7	0.6	-0.4	-0.0	-0.2
Ever taken oral contraceptive pill	0.1	0.1	0.2	-0.2	0.2	-0.3	-0.0	-0.4
Mother’s age at death	0.1	0.1	0.5	-0.0	0.7	0.0	0.0	0.4
Medication: Paracetamol	0.1	0.2	0.6	0.1	-0.5	-0.1	-0.8	-0.3
Medication: Atorvastatin	0.1	0.1	0.4	-0.3	-0.0	-0.3	-0.7	-0.4
Depressed Affect (Nagel 2018)	0.0	0.0	0.1	0.1	0.2	0.1	0.3	0.1
Crohns Disease (2012)	0.0	0.1	0.3	0.1	-0.5	0.2	0.2	-0.0
Hypothyroidism (self reported)	0.0	0.1	0.3	0.0	0.6	-0.1	-0.2	-0.0
Sensitivity / hurt feelings	0.0	0.0	0.1	-0.2	-0.2	-0.1	0.4	0.1
Trunk fat percentage	0.0	0.0	0.1	0.2	0.2	0.1	-0.0	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.0	0.1	0.2	-0.2	-0.5	-0.2	0.0	-0.1
Taking other prescription medications	0.0	0.1	0.2	0.4	0.1	0.4	0.2	0.3
Medication: Atenolol	0.0	0.0	0.1	-0.1	-0.3	-0.2	-0.3	-0.1
Medication: Levothyroxine sodium	0.0	0.0	0.1	0.1	0.2	0.1	0.0	0.2
Arm fat percentage (right)	0.0	0.1	0.2	0.1	0.2	-0.1	-0.3	-0.4
Medication: Cholesterol lowering	0.0	0.0	0.3	0.0	0.5	0.0	-0.1	0.2
Hypothyroidism/myxoedema (self-reported)	0.0	0.0	0.2	0.1	0.5	0.1	0.0	0.2
Body fat percentage	0.0	0.1	0.3	-0.2	-0.0	-0.3	-0.5	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.0	0.0	0.2	0.2	0.0	-0.0	-0.4	-0.0
Number of full sisters	0.0	0.0	0.1	-0.3	-0.0	-0.3	-0.2	-0.3
High cholesterol (Self-reported)	0.0	0.0	0.1	0.2	0.4	0.2	-0.1	0.3
Diastolic blood pressure, automated reading	0.0	0.1	0.4	0.3	-0.6	0.1	-0.1	0.1
Commuting to job workplace: Cycle	0.0	0.0	0.1	-0.2	-0.0	0.0	0.3	0.1

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