Hub : Genes

TMEM97

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.0910	0.0400	2.8e-03	0.048	NA	0.034	NA	0.039	1.6e-04	NA	1.4e-03	NA	6.3e-04
2	TCGA	Kidney Renal Clear Cell Carcinoma	0.1210	0.0461	2.7e-07	0.007	0.057	0.060	NA	0.026	4.9e-02	5.6e-07	2.6e-07	NA	5.7e-04
3	TCGA	Kidney Renal Papillary Cell Carcinoma	0.1250	0.0560	1.6e-04	0.081	0.052	0.060	NA	0.063	2.1e-05	5.8e-04	2.4e-04	NA	1.8e-04
4	TCGA	Brain Lower Grade Glioma	0.0467	0.0237	1.7e-03	0.010	0.014	0.027	NA	0.013	2.4e-02	8.6e-03	4.5e-04	NA	1.1e-02
5	TCGA	Pheochromocytoma and Paraganglioma	0.3080	0.0980	3.5e-05	0.089	0.057	0.140	NA	0.061	2.2e-04	2.8e-03	3.5e-06	NA	1.9e-03
6	TCGA	Prostate Adenocarcinoma	0.0964	0.0436	2.4e-04	0.033	0.024	0.035	NA	0.021	1.9e-04	1.3e-03	1.4e-04	NA	2.8e-03
7	TCGA	Thyroid Carcinoma	0.1720	0.0630	2.6e-10	0.109	0.078	0.095	NA	0.106	1.0e-10	5.3e-08	1.7e-09	NA	1.8e-10

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	1.2	1.9	3.3	-1.1	-1.3	0.0	1.5	-1.2	-1.8	-1.8
Bipolar Disorder or Schizophrenia	0.0	0.0	0.1	0.1	0.1	0.0	-0.3	-0.0	-0.3	-0.2
Depressed Affect (Nagel 2018)	0.6	1.3	3.7	1.0	1.9	0.4	-0.8	1.4	1.2	0.4
Depression (Nagel 2018)	2.9	4.4	6.2	2.5	2.2	2.1	-2.0	1.4	1.9	2.3
Intelligence (Savage-Jansen 2018)	0.4	1.1	2.3	1.3	0.0	1.4	-0.1	0.8	1.2	1.5
Neuroticism (Nagel 2018)	0.4	0.9	1.6	0.6	1.3	0.6	-1.3	1.0	1.0	0.7
Schizophrenia (2018)	0.6	1.2	2.5	1.0	1.2	0.0	-1.6	1.0	1.0	1.2
Schizophrenia vs Biploar Disorder	2.8	3.7	5.9	1.9	1.7	0.0	-2.4	1.8	2.2	2.2
Worry (Nagel 2018)	0.1	0.2	1.0	0.5	0.2	0.2	-1.0	-0.3	-0.1	0.5
Alzheimer’s Disease (in mother)	1.8	2.1	5.3	-1.2	-1.5	-1.0	2.3	-1.2	-1.5	-1.1
Alzheimer’s Disease (in father)	0.8	0.9	2.3	0.8	1.5	0.3	-1.0	0.5	1.3	0.6
Alzheimer’s Disease (including proxy)	0.1	0.1	0.4	-0.2	0.1	-0.5	0.6	-0.3	-0.2	-0.4
Crohns Disease (2017)	0.1	0.3	0.7	-0.2	-0.7	0.4	0.7	-0.6	-0.8	0.1
Irritable Bowel Disease (IBD)	0.8	1.8	3.9	-1.0	-1.9	-0.7	0.8	-1.5	-2.0	-0.9
Ulcerative Colitis (UC)	1.3	2.4	4.7	-1.5	-2.2	-1.2	0.3	-1.3	-2.1	-1.4
Major Depression (MDD)	0.2	0.3	0.6	0.8	0.3	0.5	-0.4	0.7	0.3	0.5
Reaction Time	1.5	2.9	6.9	0.8	2.6	0.4	-2.0	1.7	2.2	1.0
Verbal and Numeric Reasoning (VNR)	0.3	0.8	1.6	1.1	0.2	1.1	0.5	0.3	1.1	1.3
Breast Cancer	0.2	0.5	1.1	0.5	0.0	1.1	-1.0	0.7	-0.1	0.7
Ovarian Cancer	0.2	0.3	1.2	0.4	0.7	0.3	-1.1	-0.2	0.2	0.2
Prostate Cancer	2.6	3.6	7.4	-1.9	-1.1	-2.7	0.9	-2.1	-1.6	-2.2
Age at First Birth	0.5	0.8	2.0	1.4	1.1	0.0	-1.3	-0.2	0.3	0.1
Bipolar Disorder (2011)	0.0	0.0	0.2	-0.4	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.5	0.7	1.7	1.3	1.3	0.0	-1.2	-0.2	0.3	-0.1
Coronary Artery Disease (CAD)	0.0	0.1	0.4	0.6	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.1	0.2	0.4	-0.4	-0.5	0.0	0.7	-0.2	-0.6	-0.2
Mean Putamen Volume	0.1	0.2	0.3	0.2	-0.6	0.3	-0.6	-0.1	-0.6	0.0
Fasting Glucose	2.2	2.6	5.9	0.5	1.9	0.0	-2.3	0.9	1.7	2.4
HbA1C	1.8	2.0	5.6	0.0	1.5	0.0	-2.4	0.9	1.4	1.8
HDL Cholesterol	1.4	2.4	8.6	-1.8	-1.7	0.0	2.9	-0.6	-1.1	-0.6
LDL Cholesterol	3.0	4.8	11.7	2.0	1.6	0.0	-2.8	1.5	2.2	3.4
Lupus	0.2	0.3	1.1	-0.2	0.6	-1.1	0.3	0.1	0.4	-0.7
Neuroticism (2016)	0.8	1.2	4.9	1.1	0.8	0.7	-2.2	0.8	0.2	0.6
Primary Biliary Cirrhosis	3.8	5.5	8.0	1.8	2.6	1.9	-2.3	2.7	2.8	2.1
Rheumatoid Arthritis	1.5	2.0	3.8	1.2	1.4	1.1	-0.7	1.8	1.9	1.4
Schizophrenia (2014)	0.1	0.1	0.3	0.4	0.5	0.0	-0.5	0.5	0.2	0.2
Triglycerides	0.2	0.4	1.1	-1.0	0.5	0.0	0.3	0.6	-0.1	-1.1
Type 2 Diabetes (T2D) (2012)	0.5	0.6	2.8	1.7	0.0	0.0	0.0	0.0	0.0	1.1
Ulcerative Colitis	2.3	3.3	7.2	-1.6	-2.2	0.0	1.0	-2.1	-2.7	-1.7
Blood Eosinophil Count	0.2	1.3	2.4	1.3	1.3	1.0	0.5	1.2	1.6	1.0
Blood Platelet Count	0.5	5.3	7.8	2.6	0.8	2.8	-2.3	1.9	2.3	2.7
Blood Red Count	0.1	0.9	3.2	0.9	-0.0	1.8	-0.2	1.3	0.3	0.7
Blood White Count	0.1	0.6	1.6	0.8	1.2	-0.8	0.6	-0.3	1.1	-0.0
Heel T-Score	5.7	45.0	65.6	-8.1	-5.8	-7.5	6.2	-4.1	-6.3	-8.1
BMI	0.8	4.6	7.4	2.7	1.7	2.4	-1.0	2.2	2.2	2.2
Height	0.8	15.3	22.8	3.9	2.7	4.5	-2.8	3.9	4.3	4.8
Waist Hip Ratio (WHR)	0.6	2.8	4.0	-1.6	-1.6	-1.9	0.8	-1.7	-1.8	-2.0
Systolic Blood Pressure	0.6	2.8	10.8	-1.3	0.5	-3.3	-0.4	-1.0	-0.3	-2.4
Smoking Status	0.1	0.3	1.2	0.1	-0.4	-0.3	0.4	-1.1	-0.6	-0.4
Allergy or Eczema	0.4	1.1	4.3	0.5	0.6	1.1	0.9	2.1	0.4	0.8
Cardiovascular Disease	0.1	0.3	1.0	0.3	0.4	-1.0	-1.0	0.1	0.4	-0.4
Hypothyroidism (self reported)	0.4	0.9	2.6	0.7	-0.4	1.6	1.1	0.7	0.1	1.1
Respiratory disease	1.4	3.2	6.2	1.6	2.3	1.3	-2.5	1.3	1.6	1.5
Type 2 Diabetes (T2D) (2018)	0.7	1.2	3.0	0.5	1.7	-0.9	-1.3	1.0	1.2	-0.7
Lung FEV1/FVC ratio	0.5	2.6	5.8	-2.4	-0.9	-2.0	1.3	-0.5	-1.0	-2.2
Lung FVC	0.1	0.3	1.0	0.5	1.0	-0.4	0.1	0.4	0.6	-0.2
Neuroticism	1.4	3.4	4.3	2.0	2.1	1.7	-2.0	1.5	1.7	1.8
Chronotype (morning person)	0.1	0.1	0.5	0.1	0.4	-0.2	-0.7	0.2	-0.2	-0.3
Hair Pigment	0.0	1.4	2.8	1.1	1.6	0.4	-0.6	1.4	1.7	0.8
Tanning	0.0	0.4	1.2	-0.0	-1.1	0.5	-0.0	-0.5	-0.7	0.7
Hand grip strength (left)	0.1	0.3	0.9	-0.4	-0.9	-0.2	0.1	-0.7	-0.7	-0.4
Number of treatments/medications taken	0.2	0.3	1.3	0.1	-0.0	-1.1	-0.3	0.2	-0.1	-0.9
Average weekly spirits intake	0.2	0.2	0.9	-1.0	-0.3	-0.3	0.2	-0.0	-0.5	-0.6
Sensitivity / hurt feelings	0.4	0.7	1.7	0.9	-0.0	1.3	-0.9	0.7	0.4	1.1
Frequency of depressed mood in last 2 weeks	0.8	1.1	2.3	1.5	0.6	1.0	-1.2	0.5	0.8	1.2
Hearing difficulty/problems: Yes	0.3	0.5	1.0	-0.5	-0.7	-1.0	0.3	-0.6	-0.9	-0.7
Relative age of first facial hair	1.0	2.0	3.8	1.9	0.4	1.6	-1.6	0.7	1.0	1.7
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.6	0.8	0.4	-0.2	-0.7	-0.3	0.2	0.2
Ever used hormone-replacement therapy (HRT)	1.0	1.3	1.9	-1.4	-1.1	-1.2	0.8	-0.9	-1.3	-1.1
Ever had hysterectomy (womb removed)	0.3	0.4	0.7	0.8	0.3	0.4	-0.4	0.8	0.8	0.7
Systolic blood pressure, automated reading	1.2	3.4	10.6	-1.9	-0.4	-3.3	0.7	-1.0	-0.8	-2.7
Eye problems/disorders: Diabetes related eye disease	1.9	2.1	2.4	-1.4	-1.5	-1.5	1.4	-1.5	-1.4	-1.4
Angina	1.0	1.3	3.0	1.7	0.5	1.1	-1.4	0.6	1.0	1.2
Medication for hormone replacement therapy	0.3	0.3	0.8	-0.4	-0.5	-0.6	0.2	-0.9	-0.5	-0.4
Vitamin and mineral supplements	1.8	2.4	7.5	-1.2	-2.0	-0.6	2.7	-0.5	-1.4	-1.1
Supplements: Zinc	1.0	1.1	2.4	0.9	0.8	1.6	-1.0	1.0	0.7	1.2
Medication: Co-codamol	0.2	0.3	0.7	0.5	0.6	-0.8	-0.6	-0.2	0.4	-0.3
Medication: Metformin	1.2	1.8	4.0	0.6	2.0	-0.7	-1.9	1.2	1.4	-0.4
Diabetes (father)	1.5	1.8	3.5	1.4	1.5	0.9	-1.2	1.3	1.9	1.2
Diabetes (mother)	0.2	0.3	0.8	0.5	-0.5	0.7	0.9	-0.3	-0.2	0.6
Severe depression (siblings)	0.9	1.0	3.1	-0.2	-1.5	-0.3	-0.2	-1.8	-1.2	-0.1
Pack years adult smoking proportion	2.4	3.6	5.6	2.3	2.1	1.7	0.5	1.9	2.4	1.9
Impedance of leg (right)	0.8	4.1	5.9	-2.4	-1.8	-2.3	1.0	-1.8	-2.0	-2.4
Leg fat-free mass (left)	2.9	15.1	19.3	4.2	3.5	4.2	-2.6	3.6	4.4	4.4
Trunk fat percentage	0.8	3.3	5.7	1.8	2.4	1.0	-1.5	2.1	2.3	1.2
Hand grip strength (right)	0.1	0.3	1.3	-0.5	-1.1	0.0	-0.0	-0.4	-0.8	-0.2
Townsend deprivation index at recruitment	0.3	0.5	1.1	1.0	0.6	0.7	0.0	0.2	0.9	0.7
Current tobacco smoking	0.8	1.4	3.6	1.9	0.4	1.7	-0.1	-0.2	0.8	1.6
Average weekly fortified wine intake	0.2	0.2	0.4	-0.2	-0.5	0.6	-0.4	0.4	0.5	0.5
Maternal smoking around birth	1.1	1.6	3.6	1.2	1.9	0.6	-1.1	1.4	1.4	0.7
Fed-up feelings	0.8	1.4	4.1	1.2	2.0	0.5	-0.8	1.1	1.4	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	2.0	2.7	3.6	1.9	1.7	1.7	-1.6	1.1	1.6	1.7
Relative age voice broke	1.4	2.1	3.6	1.9	1.5	1.2	-1.9	0.6	1.5	1.3
Taking other prescription medications	0.3	0.5	1.7	-0.3	-0.3	-1.3	0.5	0.1	-0.0	-1.0
Age when periods started (menarche)	0.6	1.5	3.4	1.0	0.7	1.8	-0.7	1.4	1.0	1.5
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.7	0.6	-0.8	0.8	-0.3	0.1	-0.3	0.7
Heel bone mineral density (BMD) T-score, automated (left)	5.2	11.7	15.8	-4.0	-3.4	-3.3	3.4	-2.4	-3.5	-3.7
Tinnitus: Yes, but not now, but have in the past	0.7	0.8	1.9	-0.2	-1.3	0.1	0.6	-1.2	-1.4	-0.3
Qualifications: CSEs or equivalent	0.0	0.0	0.2	0.1	-0.4	0.1	0.0	0.1	-0.1	0.2
Serious illness, injury or assault to yourself	0.3	0.4	1.4	-0.3	-1.2	0.5	0.0	-0.4	-0.6	0.4
High blood pressure	0.9	2.5	8.5	-1.2	-0.7	-2.9	0.1	-1.1	-0.8	-2.3
Hayfever, allergic rhinitis or eczema	0.9	1.8	6.5	0.5	1.3	1.4	0.4	2.5	0.9	1.1
Multivitamins +/- minerals	2.0	2.5	4.1	1.4	2.0	1.3	-1.8	1.0	1.8	1.6
Stomach or abdominal pain in last month	0.6	0.7	2.1	0.8	1.4	0.2	-1.3	0.2	0.9	0.3
Supplements: Glucosamine	1.1	1.4	3.2	-1.2	-0.9	-1.1	0.2	-1.3	-1.8	-1.3
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	1.1	0.7	0.4	0.3	-1.1	0.8	0.6	0.3
Medication: Atenolol	0.6	0.8	1.9	-0.1	-0.6	-1.1	-0.3	-1.4	-0.9	-1.0
Medication: Levothyroxine sodium	0.1	0.1	0.3	0.3	0.1	0.5	0.5	0.4	-0.0	0.2
Sitting height	0.8	6.0	9.4	2.3	2.1	2.4	-1.5	3.0	3.1	2.5
Chronic bronchitis/emphysema (father)	2.3	2.7	4.8	2.2	2.0	1.0	-1.7	1.1	1.7	1.6
High blood pressure (mother)	1.4	2.0	4.5	-1.9	-0.7	-2.1	0.9	-0.4	-0.8	-2.0
Body mass index (BMI)	0.6	2.5	3.9	1.7	2.0	1.2	-1.1	1.8	1.9	1.1
Impedance of leg (left)	1.4	6.7	9.2	-2.9	-2.4	-3.0	1.3	-2.3	-2.8	-3.0
Leg predicted mass (left)	2.8	15.1	19.2	4.1	3.5	4.2	-2.6	3.6	4.4	4.4
Trunk fat mass	1.7	7.3	10.7	2.8	3.1	2.1	-2.2	2.9	3.3	2.3
Waist circumference	1.0	3.8	5.1	2.2	2.1	1.6	-1.9	1.8	2.2	1.7
Number of incorrect matches in round	0.9	1.4	3.6	-0.9	-0.5	-1.3	-1.9	-1.2	-0.9	-1.2
Past tobacco smoking	0.8	1.5	3.0	1.3	0.9	1.7	-0.9	1.2	0.8	1.5
Alcohol usually taken with meals	1.7	2.8	3.8	-1.9	-1.9	-1.7	0.5	-1.6	-1.8	-1.8
Nervous feelings	0.2	0.3	0.8	-0.1	-0.2	-0.6	-0.7	-0.9	-0.7	-0.3
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.6	3.3	1.8	0.9	1.1	-1.6	0.9	1.2	1.3
Hearing difficulty/problems with background noise	0.1	0.2	1.1	0.3	0.5	-0.0	-1.0	-0.0	-0.1	0.0
Hair/balding pattern: Pattern 2	1.1	1.4	2.6	-1.0	-1.2	-1.2	1.6	-1.1	-1.0	-1.2
Had menopause	0.2	0.2	0.6	-0.0	0.7	-0.4	-0.8	0.1	0.2	-0.1
Had other major operations	1.3	1.5	3.1	1.6	1.2	1.1	-1.8	0.9	0.5	1.2
Forced vital capacity (FVC)	1.0	4.0	5.5	2.2	2.2	1.9	-1.1	1.7	2.4	2.2
Heel bone mineral density (BMD) T-score, automated (right)	5.1	11.6	15.7	-4.0	-3.1	-3.5	3.9	-2.0	-3.2	-3.9
Ever unenthusiastic/disinterested for a whole week	0.9	1.2	2.4	0.7	0.7	1.6	-1.0	1.2	1.0	1.2
Qualifications: None of the above	1.3	2.7	6.1	1.5	2.5	1.1	-1.3	1.5	1.9	1.3
Financial difficulties in last 2 years	0.5	0.6	1.1	0.6	0.5	0.9	-1.0	0.5	1.0	0.9
Mouth/teeth dental problems	4.2	6.5	8.3	-2.6	-2.5	-2.8	2.4	-1.9	-2.5	-2.9
Heart attack	0.2	0.2	0.4	0.3	-0.7	0.2	0.6	-0.6	-0.4	-0.1
Allergy	0.8	1.7	4.2	-0.9	-1.2	-1.6	0.3	-2.1	-1.0	-1.4
Pain all over the body in last month	0.6	0.6	1.5	0.9	0.4	0.8	-1.2	0.3	0.5	0.9
Diabetes (self-reported)	0.5	0.7	2.0	-0.7	0.3	-1.4	-0.6	0.0	0.2	-1.4
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.3	1.0	0.9	0.5	-0.1	1.1	0.4	0.6
Medication: Ramipril	0.3	0.4	1.6	0.4	0.1	0.2	1.3	0.8	0.5	0.1
Medication: Simvastatin	0.4	0.6	4.3	0.4	0.0	-0.2	-2.1	-0.2	0.0	0.0
Fluid intelligence score	0.1	0.2	0.6	0.3	-0.6	0.8	0.2	-0.1	0.0	0.7
Illnesses of siblings	0.5	0.7	2.7	0.7	-0.0	1.6	0.3	0.5	0.4	1.2
Neuroticism score	1.5	3.2	4.4	2.1	1.9	1.6	-2.0	1.4	1.6	1.8
Weight	2.2	10.8	14.2	3.5	3.4	3.0	-2.8	3.2	3.8	3.2
Impedance of arm (right)	0.2	0.9	2.3	-1.4	-0.2	-1.5	0.5	-0.4	-0.3	-1.2
Arm fat percentage (right)	0.7	2.9	5.4	1.5	2.3	1.0	-1.1	2.1	2.3	1.0
Trunk fat-free mass	2.1	12.1	16.6	3.9	2.7	4.0	-2.6	3.1	3.7	4.1
Hip circumference	2.2	9.5	13.0	3.6	2.9	3.1	-2.1	2.8	3.4	3.4
Time employed in main current job	0.7	0.8	1.6	-0.6	-0.2	-1.1	-0.0	-1.1	-1.2	-1.3
Alcohol intake versus 10 years previously	2.5	3.7	6.9	2.1	2.1	1.2	-0.8	2.3	2.6	1.6
Father’s age at death	1.3	1.7	3.4	1.2	1.0	1.2	-0.7	1.8	1.7	1.2
Worrier / anxious feelings	0.1	0.2	0.4	0.5	-0.2	0.5	-0.1	-0.6	-0.2	0.5
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.6	2.2	0.9	1.3	1.3	-1.4	1.2	1.5	1.3
Falls in the last year	0.1	0.2	0.9	0.3	-0.3	-0.0	0.4	-1.0	-0.3	0.3
Hair/balding pattern: Pattern 3	0.4	0.6	1.7	0.8	-0.0	1.3	-0.2	0.5	0.2	1.1
Number of live births	0.1	0.2	0.4	-0.6	-0.1	-0.1	0.4	-0.6	-0.3	-0.3
Forced expiratory volume in 1-second (FEV1)	0.3	1.2	2.2	0.8	1.5	0.9	-0.1	1.3	1.4	0.9
Pulse rate	0.0	0.1	0.2	-0.1	0.1	0.5	0.4	0.2	0.0	0.1
Happiness	0.6	0.7	1.6	1.3	1.0	0.4	-0.5	-0.2	1.1	0.7
Noisy workplace	1.9	2.4	4.7	1.3	1.9	0.9	-1.5	1.4	2.2	1.3
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.4	-0.3	-0.6	0.3	-0.5	-0.0	-0.6	-0.1
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	1.2	-0.5	-0.4	0.2	1.1	0.6	-0.1	0.0
Mouth/teeth dental problems: Dentures	2.1	3.6	5.4	2.3	2.3	1.2	-2.1	1.3	2.0	1.7
Asthma	0.2	0.3	0.7	0.2	0.6	0.6	-0.8	0.6	0.6	0.5
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.2	-0.1	-0.3	-0.0	0.3	0.2	-0.5	-0.1
Medication: Cholesterol lowering	0.2	0.3	0.8	0.2	-0.9	0.0	-0.9	-0.5	-0.6	-0.0
Depression (self-reported)	0.1	0.1	0.4	0.3	0.5	-0.1	-0.6	0.2	0.3	0.1
Medication: Lansoprazole	0.5	0.6	1.2	0.7	1.0	-0.3	-1.0	0.7	1.1	0.1
Prospective memory result	1.8	2.3	3.2	1.8	1.4	1.7	-1.2	1.4	1.2	1.7
Lung cancer (father)	0.2	0.2	0.5	0.1	0.2	-0.7	-0.7	-0.4	-0.3	-0.3
Illnesses of mother	0.6	0.8	1.9	0.8	1.0	0.8	-1.4	-0.1	0.8	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.3	4.2	1.2	2.1	1.2	-0.4	1.7	1.9	1.3
Pulse wave Arterial Stiffness index	1.8	2.1	3.8	1.5	1.9	1.1	-0.6	1.4	1.9	1.1
Impedance of arm (left)	0.2	1.1	2.4	-1.5	-0.5	-1.6	0.7	-0.6	-0.6	-1.3
Arm fat mass (right)	1.3	5.3	7.8	2.3	2.6	1.8	-1.8	2.5	2.8	1.9
Trunk predicted mass	2.1	11.8	16.0	3.8	2.7	4.0	-2.6	3.1	3.7	4.0
Standing height	1.6	15.6	21.2	4.2	3.2	4.1	-3.6	3.5	4.3	4.6
Length of working week for main job	0.5	0.5	2.2	0.0	-0.9	0.1	-0.6	-1.5	-0.7	-0.0
Exposure to tobacco smoke at home	0.4	0.5	2.7	-0.1	-0.6	0.4	1.7	0.2	0.3	0.2
Breastfed as a baby	2.6	3.3	6.1	2.1	1.1	2.5	-1.2	1.3	1.6	2.4
Tense / ‘highly strung’	0.1	0.2	0.4	0.1	-0.1	-0.3	-0.6	-0.7	-0.6	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	1.0	0.5	0.5	0.1	-1.0	0.7	0.7	0.3
Hair/balding pattern: Pattern 4	0.2	0.4	1.4	0.7	0.7	-0.0	-1.2	-0.5	0.3	0.1
Birth weight of first child	0.9	1.7	3.8	1.7	0.8	1.9	-0.4	0.4	1.0	1.7
Peak expiratory flow (PEF)	0.0	0.1	0.5	-0.3	-0.0	0.0	0.3	0.7	0.3	-0.1
Pulse wave reflection index	2.3	2.9	4.2	2.1	1.7	1.8	-1.2	1.3	1.8	1.9
Ever highly irritable/argumentative for 2 days	1.3	1.5	2.4	1.4	1.4	1.5	-0.4	0.9	1.1	1.4
Loud music exposure frequency	2.4	2.6	4.2	1.8	1.4	2.0	-1.3	1.3	1.5	1.9
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.1	-0.9	-0.7	-0.6	0.4	-0.3	-1.1	-0.9
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.5	0.0	0.9	0.6	-1.2	0.3	0.2	0.1
Blood clot in the leg (DVT)	2.8	3.6	5.2	1.9	1.4	2.3	-2.0	1.8	1.4	2.3
Medication: Paracetamol	0.4	0.6	1.4	1.2	0.7	0.9	-0.5	-0.1	0.4	1.0
Headache pain in last month	1.9	3.3	4.9	1.8	1.7	2.0	-2.2	1.7	1.3	1.8
Medication for cholesterol, blood pressure or diabetes	2.0	3.2	5.3	1.3	1.9	2.3	-0.6	1.8	1.9	2.1
Glaucoma (self-reported)	1.1	1.3	2.9	-1.7	-0.4	-1.6	0.6	0.3	-0.4	-1.6
Gout (self-reported)	1.6	2.2	5.6	-1.8	-0.4	-2.4	0.3	-0.5	-1.1	-2.3
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.4	0.3	-0.3	1.2	0.7	0.5	-0.2	0.6
Medication: Amlodipine	3.8	5.3	15.6	-2.1	-0.4	-4.0	1.0	-1.6	-1.4	-3.5
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.1	-0.9	-0.4	-0.9	0.4	0.2	-0.3	-1.0
Birth weight	0.9	1.9	3.3	1.8	1.3	1.7	-0.4	0.7	1.4	1.8
Chronic bronchitis/emphysema (mother)	1.7	2.0	4.2	1.8	2.0	0.7	-2.0	0.6	1.1	0.9
High blood pressure (siblings)	1.5	2.1	4.0	-1.6	-0.6	-2.0	1.6	-0.9	-0.8	-2.0
Forced vital capacity (FVC), Best measure	1.1	4.2	7.0	2.1	2.4	1.9	-0.8	1.9	2.6	2.1
Body fat percentage	0.7	2.8	5.1	1.6	2.3	0.9	-1.6	1.9	2.1	1.0
Leg fat percentage (right)	0.5	1.7	3.4	1.1	1.8	0.7	-1.7	1.3	1.4	0.6
Arm fat-free mass (right)	2.0	10.3	13.8	3.6	2.5	3.7	-2.5	2.9	3.3	3.7
Exposure to tobacco smoke outside home	0.1	0.2	0.5	0.3	0.6	0.0	-0.4	0.5	0.7	0.1
Comparative body size at age 10	0.1	0.2	0.6	-0.4	-0.8	-0.1	0.4	-0.4	-0.5	-0.3
Number of full brothers	0.9	1.1	2.2	0.7	0.3	1.5	-1.1	0.9	1.0	1.4
Worry too long after embarrassment	0.4	0.7	2.0	0.4	0.9	0.4	-0.7	1.4	0.9	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.5	2.0	4.2	0.9	1.4	1.0	-2.1	1.5	1.6	1.1
Wheeze or whistling in the chest in last year	1.4	2.5	4.1	2.0	2.0	1.2	-1.7	1.1	1.6	1.1
Number of children fathered	0.4	0.4	1.0	-1.0	-0.4	-0.6	0.6	-0.3	-0.9	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.6	-0.7	-0.1	-0.7	-0.6	-0.4	-0.3	-0.8
Age at first live birth	1.4	2.5	3.7	-1.9	-1.6	-1.5	1.2	-1.1	-1.6	-1.8
Pulse wave peak to peak time	1.1	1.3	2.5	-1.2	-1.6	-0.8	0.3	-1.1	-1.5	-0.8
Health satisfaction	2.2	2.8	8.1	1.5	1.6	1.4	-2.8	1.0	1.5	1.3
Shortness of breath walking on level ground	4.1	4.9	8.3	2.3	2.9	1.0	-2.3	2.2	2.8	1.3
Qualifications: College or University degree	0.2	0.5	1.1	-0.5	-1.0	-0.6	-0.2	-0.8	-0.8	-0.6
Eye problems/disorders: None of the above	0.7	0.8	1.3	0.9	1.1	1.0	-0.8	0.5	0.9	0.9
Mouth/teeth dental problems: Loose teeth	1.0	1.1	3.0	0.9	0.5	1.7	-0.3	0.8	0.9	1.6
Emphysema/chronic bronchitis	0.1	0.1	0.6	-0.2	0.1	0.2	-0.8	-0.2	0.2	0.2
Medication for pain relief, constipation, heartburn	0.1	0.2	0.9	-1.0	-0.3	-0.3	0.2	-0.2	-0.2	-0.6
Neck or shoulder pain in last month	1.2	1.7	2.6	1.4	1.6	0.7	-1.5	1.1	1.5	1.1
Medication: Blood pressure	2.6	4.6	10.3	-1.8	-1.6	-3.2	1.5	-1.6	-1.6	-2.9
Angina (self-reported)	1.0	1.3	3.0	1.7	0.5	1.0	-1.3	0.6	1.0	1.1
Migraine (self-reported)	0.1	0.1	0.2	-0.4	0.2	-0.4	-0.0	-0.3	-0.5	-0.3
Medication: Ibuprofen	0.4	0.5	1.2	-0.6	-1.1	-0.3	0.9	-0.2	-0.9	-0.5
Medication: Allopurinol	0.3	0.4	1.3	-0.8	0.3	-1.1	0.0	0.0	-0.1	-0.9
Medication: Omeprazole	0.2	0.3	0.6	-0.7	-0.8	-0.1	0.6	-0.2	-0.5	-0.2
Medication: Seretide 50 evohaler	0.2	0.2	0.7	-0.2	0.0	0.5	0.9	0.0	-0.3	0.4
Mean time to correctly identify matches	1.3	2.5	6.6	0.6	2.2	0.1	-2.6	1.6	1.8	0.6
Heart disease (mother)	0.6	0.7	1.1	1.1	0.9	0.8	-0.7	0.9	0.8	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	1.4	0.1	-0.6	-0.0	0.4	-1.2	-0.7	0.1
Whole body fat mass	1.6	6.8	9.2	2.8	2.9	2.1	-2.3	2.7	3.0	2.2
Leg fat mass (right)	1.2	4.5	6.4	2.2	2.5	1.7	-2.0	2.1	2.5	1.7
Arm predicted mass (right)	2.1	10.8	14.7	3.8	2.5	3.8	-2.6	2.8	3.4	3.8
Pulse rate, automated reading	0.1	0.3	0.6	-0.7	-0.8	0.3	0.8	-0.3	-0.6	-0.2
Alcohol intake frequency.	3.1	7.3	8.9	2.9	2.8	2.8	-1.5	2.8	2.8	3.0
Comparative height size at age 10	0.7	4.1	7.3	2.7	1.7	1.6	-1.9	1.1	2.2	2.4
Number of full sisters	0.7	0.9	1.5	0.5	1.2	1.1	-0.8	0.5	1.0	1.1
Suffer from ‘nerves’	0.7	1.0	3.8	1.1	1.0	0.3	-1.9	-0.0	0.7	0.9
Overall health rating	0.7	1.4	2.2	1.5	1.4	1.0	-0.9	1.0	1.4	1.1
Chest pain or discomfort	0.1	0.1	0.6	0.8	-0.1	0.1	0.2	-0.2	0.0	0.1
Had major operations	0.2	0.2	0.3	-0.4	-0.6	-0.5	0.5	-0.2	-0.4	-0.5
Age at last live birth	1.5	2.1	3.1	-1.6	-1.1	-1.8	0.8	-1.7	-1.3	-1.7
Family relationship satisfaction	0.5	0.7	3.0	0.9	0.4	0.7	-1.7	-0.2	-0.0	0.5
Leg pain on walking	0.9	1.1	4.6	0.9	0.3	1.2	-2.1	-0.3	-0.2	1.0
Qualifications: NVQ or HND or HNC or equivalent	1.8	2.2	3.6	-1.9	-1.4	-1.1	1.3	-1.2	-1.8	-1.5
Commuting to job workplace: Car/motor vehicle	1.1	1.2	2.6	0.8	1.3	0.6	-1.6	1.1	1.1	0.8
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	0.7	-0.5	0.2	-0.8	0.8	-0.3	-0.3	-0.8
Medication: Aspirin	0.2	0.2	0.9	0.3	-0.9	0.1	0.7	-0.3	-0.4	0.0
Supplements: Vitamin C	1.7	2.0	5.5	1.2	1.5	0.8	-2.3	0.9	1.5	1.0
Knee pain experienced in last month	0.2	0.2	0.9	0.4	0.9	0.3	-0.7	0.3	0.2	0.2
Hypertension (Self-reported)	1.2	3.3	10.5	-1.5	-0.9	-3.2	0.3	-1.3	-0.8	-2.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.0	0.1	0.2	-0.3	-0.3	-0.0	0.3	0.4	0.0	-0.1
Illnesses of father: Heart disease	0.0	0.0	0.1	0.3	-0.2	-0.2	-0.2	-0.1	-0.2	-0.3
Illnesses of siblings: Diabetes	0.3	0.4	1.4	-0.1	0.7	-0.8	-1.2	-0.5	-0.0	-0.4
Smoking status: Previous	0.8	1.3	2.7	-1.3	-0.7	-1.6	0.7	-0.9	-0.8	-1.4
Forced expiratory volume in 1-second (FEV1), predicted	1.4	2.8	3.8	1.6	1.7	1.5	-1.7	1.5	1.9	1.8
Whole body fat-free mass	2.4	13.9	18.5	4.1	3.1	4.2	-2.8	3.3	4.0	4.3
Leg fat-free mass (right)	2.5	13.2	16.5	3.9	3.3	3.9	-2.6	3.4	4.1	4.0
Arm fat percentage (left)	0.7	2.7	5.0	1.4	2.2	1.0	-1.1	2.0	2.1	1.0
Average weekly red wine intake	4.5	6.7	9.1	-2.6	-2.9	-2.6	1.0	-2.9	-3.0	-2.7
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.6	-0.8	0.7	-0.3	-0.6	-0.1	0.0	-0.4
Mood swings	1.3	2.3	3.4	1.6	1.7	1.4	-0.5	1.8	1.7	1.4
Loneliness, isolation	0.1	0.1	0.4	0.6	0.4	0.2	-0.1	-0.0	0.1	-0.0
Long-standing illness, disability or infirmity	0.6	0.9	3.4	0.8	0.9	-0.2	-1.8	1.0	0.7	-0.1
Ever had bowel cancer screening	1.0	1.2	2.0	1.1	0.9	1.0	-1.2	1.4	0.9	0.9
Diabetes diagnosed by doctor	0.5	0.8	1.9	-0.4	0.7	-1.4	-1.0	0.2	0.4	-1.3
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.8	-0.2	-0.4	0.5	-0.1	-0.5	-0.9	0.0
Friendships satisfaction	1.4	1.7	3.2	1.4	1.7	0.9	-1.8	0.8	1.2	1.1
Qualifications: nursing, teaching	1.6	2.6	4.2	-2.0	-1.9	-1.6	0.9	-0.6	-1.6	-1.9
Commuting to job workplace: Walk	4.9	5.2	7.6	-2.5	-2.8	-1.4	2.3	-2.1	-2.7	-1.9
Eye problems/disorders: Cataract	0.2	0.3	0.9	0.4	-0.3	0.4	-0.6	0.9	0.1	0.4
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.6	0.0	-0.8	0.7	0.2	-0.7	-0.4	0.5
Medication for cholesterol	1.8	2.7	6.9	-1.9	-1.7	-0.5	2.6	-1.1	-1.7	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.0	2.5	1.1	0.2	1.4	-0.7	0.5	0.8	1.6
Back pain experienced in last month	1.5	2.1	3.8	0.9	2.0	1.3	-1.3	1.3	1.8	1.5
Mineral and other dietary supplements	0.9	1.3	2.5	0.9	0.4	0.9	1.5	1.3	1.6	0.9
Breast cancer (self-reported)	0.9	1.1	2.6	1.6	1.0	0.5	-0.8	0.2	1.4	1.1
Asthma (self-reported)	0.2	0.3	0.7	0.1	0.8	0.4	-0.8	0.5	0.6	0.3
Osteoporosis (self-reported)	1.1	1.4	3.5	1.9	0.8	0.7	-0.7	0.6	1.5	1.3
Osteoarthritis (self-reported)	1.5	2.0	4.3	-1.0	-1.2	-1.4	0.5	-2.1	-1.8	-1.3
Medication: Aspirin	0.2	0.2	0.8	0.5	-0.9	0.2	0.5	-0.2	-0.1	0.2
Medication: Gliclazide	0.2	0.2	1.1	0.1	-0.1	0.2	-1.1	0.3	0.3	-0.2
Illnesses of father: None of the above (group 1)	1.2	1.5	3.8	-1.6	-1.9	-0.2	0.6	-1.1	-1.5	-0.5
Smoking status: Current	0.7	1.1	2.7	1.6	0.4	1.5	-0.4	-0.4	0.6	1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.0	0.1	0.2	-0.2	0.5	-0.3	0.5	0.2	0.2	-0.2
Whole body water mass	2.4	13.5	18.1	4.1	3.0	4.2	-2.7	3.2	4.0	4.2
Leg predicted mass (right)	2.4	12.9	16.1	3.9	3.2	3.8	-2.6	3.4	4.0	4.0
Arm fat mass (left)	1.2	5.0	7.2	2.2	2.5	1.9	-1.9	2.5	2.7	1.8
Number of self-reported non-cancer illnesses	0.2	0.3	0.9	-0.0	0.1	-0.9	-0.9	0.0	-0.1	-0.6
Average weekly champagne plus white wine intake	0.8	1.2	3.9	-0.5	-2.0	-0.2	1.6	-0.9	-0.8	-0.3
Miserableness	1.2	2.0	4.4	1.3	2.1	0.8	-1.7	1.6	1.2	0.8
Guilty feelings	1.0	1.5	2.5	1.0	1.0	1.6	-0.1	1.5	1.4	1.3
Wears glasses or contact lenses	0.3	0.3	1.3	-0.6	-0.2	-1.1	-0.0	-0.3	-0.0	-0.8
Ever taken oral contraceptive pill	0.6	0.7	2.1	0.9	0.3	1.5	0.3	0.3	0.4	1.2
Hearing aid user	0.8	0.9	3.0	-1.3	-0.7	-0.3	1.7	0.1	-0.5	-0.8
Mother’s age at death	0.1	0.2	0.5	0.2	-0.1	0.1	0.7	0.7	-0.0	-0.0
Financial situation satisfaction	0.9	1.1	2.6	0.9	1.1	0.8	-1.6	0.7	1.1	0.8
Tinnitus: Yes, now most or all of the time	1.9	2.3	4.1	2.0	1.5	1.3	-0.5	0.9	1.9	1.8
Commuting to job workplace: Public transport	0.1	0.2	1.1	0.1	-0.2	0.3	1.0	0.1	-0.1	0.2
Eye problems/disorders: Glaucoma	1.5	1.8	4.5	-2.1	-0.8	-1.6	0.1	-0.4	-1.0	-1.8
Medication: Blood pressure	1.0	1.8	6.9	0.7	1.7	-0.7	-2.6	0.7	1.3	-0.3
Pain type(s) experienced in last month: Hip pain	0.0	0.1	0.1	0.3	-0.1	0.3	-0.2	0.1	0.2	0.3
Supplements: Fish oil (including cod liver oil)	0.5	0.7	1.1	-0.7	-0.3	-0.9	-0.5	-1.1	-1.0	-0.9
High cholesterol (Self-reported)	2.0	3.5	7.7	2.0	1.5	1.8	-2.8	1.4	1.5	1.8
Medication: Bendroflumethiazide	0.5	0.7	2.4	-0.8	-0.1	-1.5	-0.2	-0.2	-0.2	-1.4
Medication: Paracetamol	0.3	0.4	0.8	0.9	0.3	0.9	0.4	-0.4	0.1	0.9
Medication: Lisinopril	0.7	0.9	3.9	0.1	0.9	-0.6	-2.0	0.6	0.8	-0.3
Medication: Atorvastatin	1.2	1.5	2.9	1.7	0.6	1.5	-0.5	1.4	1.0	1.2
Illnesses of father: High blood pressure	0.7	0.9	1.8	-0.9	-0.1	-1.4	0.5	-1.1	-0.8	-1.1
Alcohol drinker status: Never	0.9	1.1	3.3	0.7	0.5	1.8	-0.6	0.5	0.5	1.7
Ever smoked	0.9	1.6	3.3	-1.1	-1.1	-1.8	0.9	-1.2	-0.7	-1.5
Basal metabolic rate	2.3	12.6	15.7	3.9	3.1	3.9	-2.7	3.2	3.9	4.0
Leg fat percentage (left)	0.4	1.3	2.5	1.0	1.6	0.5	-1.5	1.2	1.2	0.4
Arm fat-free mass (left)	1.9	9.8	12.7	3.5	2.6	3.6	-2.5	2.8	3.3	3.5
Number of operations (self-reported)	0.4	0.6	1.2	1.1	0.3	1.0	-0.9	0.7	0.1	0.8
Average weekly beer plus cider intake	1.5	2.2	2.9	1.2	1.7	1.6	-1.3	1.7	1.5	1.4
Irritability	0.8	1.4	2.8	1.4	1.0	0.9	-1.7	1.0	1.1	1.0
Risk taking	0.3	0.4	1.3	0.0	-0.8	1.1	-0.0	0.0	-0.3	0.7
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.4	0.2	0.2	-0.7	-0.1	-0.1	-0.1	-0.3
Fractured/broken bones in last 5 years	0.8	1.1	2.5	0.4	-1.4	1.1	1.6	-0.3	-0.6	1.0
Age started oral contraceptive pill	0.4	0.5	2.7	0.5	0.6	-0.5	-1.6	0.0	0.1	-0.1
Diastolic blood pressure, automated reading	0.3	0.8	1.7	-0.8	1.0	-1.3	0.7	0.7	0.8	-1.0
Ever depressed for a whole week	0.5	0.7	1.8	0.3	0.1	1.3	0.1	1.4	0.7	0.8
Unable to work because of sickness or disability	0.3	0.4	1.0	0.1	-0.6	-0.4	0.8	-1.0	-0.7	-0.2
Commuting to job workplace: Cycle	1.8	2.1	3.0	1.5	1.3	1.3	-1.6	1.3	1.7	1.5
Myopia	0.3	0.5	1.2	-0.4	-1.0	-0.4	1.1	-0.6	-0.6	-0.4
Vascular/heart problems diagnosed by doctor	1.0	2.7	8.0	1.2	1.1	2.8	-0.2	1.3	1.1	2.2
Cholesterol lowering medication	4.3	6.3	9.0	2.8	2.4	2.1	-3.0	2.4	2.5	2.2
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.3	-0.2	-0.1	-0.2	-0.5	0.3	0.2	0.0
Pain experienced in last month	2.7	4.5	6.3	-2.0	-2.1	-2.5	2.2	-1.8	-1.8	-2.5
Supplements: Calcium	2.3	2.5	4.9	2.2	1.1	1.2	-2.2	-0.3	1.4	1.8
Basal cell carcinoma (self-reported)	0.1	0.2	0.4	0.6	-0.2	-0.1	-0.4	0.4	0.5	0.3
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.3	0.3	-0.6	0.2	0.5	-0.5	-0.4	-0.0
Deep venous thrombosis (DVT) (self-reported)	2.5	3.3	5.2	1.9	1.4	2.1	-1.8	1.7	1.4	2.3
Heart disease (siblings)	0.3	0.3	0.9	0.6	-0.6	0.1	-1.0	-0.5	-0.5	0.3
Alcohol drinker status: Previous	0.4	0.5	1.4	-0.8	0.4	-1.2	0.6	-0.0	0.1	-0.9
Pack years of smoking	2.9	4.3	6.4	2.5	2.2	1.9	0.0	2.1	2.5	2.1
Impedance of whole body	0.5	2.5	4.6	-2.0	-1.1	-2.1	0.7	-1.3	-1.4	-2.0
Leg fat mass (left)	1.0	3.9	5.5	2.1	2.3	1.6	-1.8	2.1	2.3	1.6
Arm predicted mass (left)	1.9	9.8	12.7	3.5	2.5	3.6	-2.6	2.8	3.2	3.5