Hub : Genes

SARM1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Tibial 0.0855 0.0363 0.00054 0.052 NA 0.024 NA -0.004 6.2e-05 NA 4.8e-03 NA 9.2e-01
2 YFS Blood 0.1114 0.0244 0.00000 0.086 0.111 0.136 0.133 0.139 9.3e-27 3.1e-34 4.2e-42 3.4e-41 2.8e-43

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.2 0.3 0.7 0.8 0.1
Bipolar Disorder or Schizophrenia 0.2 0.5 0.8 -0.6 0.9
Depressed Affect (Nagel 2018) 0.8 1.8 1.9 1.3 -1.4
Depression (Nagel 2018) 1.2 1.8 2.8 -1.7 0.9
Intelligence (Savage-Jansen 2018) 1.1 3.3 5.5 -2.3 1.0
Neuroticism (Nagel 2018) 0.5 1.2 1.7 1.3 -0.9
Schizophrenia (2018) 0.7 1.6 2.0 -1.4 1.0
Schizophrenia vs Biploar Disorder 1.0 1.4 2.0 -1.4 0.9
Worry (Nagel 2018) 0.0 0.1 0.1 -0.2 0.3
Alzheimer’s Disease (in mother) 1.1 1.2 1.9 1.4 -0.8
Alzheimer’s Disease (in father) 0.6 0.7 0.8 -0.7 -0.9
Alzheimer’s Disease (including proxy) 0.4 0.6 0.7 0.7 -0.9
Crohns Disease (2017) 0.3 0.7 0.8 -0.7 0.9
Irritable Bowel Disease (IBD) 0.0 0.0 0.1 -0.3 0.1
Ulcerative Colitis (UC) 0.1 0.1 0.1 0.4 -0.2
Major Depression (MDD) 0.3 0.3 0.5 -0.2 0.7
Reaction Time 0.5 0.9 1.7 -1.3 -0.2
Verbal and Numeric Reasoning (VNR) 0.3 0.7 1.2 -1.1 0.4
Breast Cancer 1.3 3.2 4.9 -2.2 1.2
Ovarian Cancer 1.7 2.3 4.5 -0.1 2.1
Prostate Cancer 2.6 3.6 5.6 2.4 -1.3
Age at First Birth 0.1 0.1 0.1 -0.3 -0.2
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 -0.0
Body Mass Index (BMI) (2010) 0.2 0.3 0.4 -0.7 0.3
Coronary Artery Disease (CAD) 1.7 2.0 3.9 -0.4 2.0
Crohns Disease (2012) 0.0 0.0 0.0 0.2 -0.0
Mean Putamen Volume 0.1 0.1 0.1 -0.0 -0.3
Fasting Glucose 0.2 0.3 0.3 -0.6 -0.4
HbA1C 0.6 0.7 1.3 -1.2 -0.1
HDL Cholesterol 1.5 2.6 3.5 1.3 -1.9
LDL Cholesterol 5.3 8.4 14.1 -3.7 1.7
Lupus 0.5 0.7 1.5 -0.1 -1.2
Neuroticism (2016) 0.6 0.8 1.5 -0.3 -1.2
Primary Biliary Cirrhosis 2.5 3.6 3.9 -2.0 1.8
Rheumatoid Arthritis 1.8 2.4 4.1 -0.9 -2.0
Schizophrenia (2014) 0.3 0.6 0.7 -0.8 0.8
Triglycerides 1.5 2.5 2.9 1.4 -1.7
Type 2 Diabetes (T2D) (2012) 0.3 0.4 0.6 -0.4 0.8
Ulcerative Colitis 0.1 0.1 0.1 -0.0 -0.4
Blood Eosinophil Count 0.4 2.8 4.8 0.9 -2.2
Blood Platelet Count 1.5 17.4 29.6 -5.4 2.3
Blood Red Count 0.7 6.7 10.7 -3.3 1.6
Blood White Count 0.4 3.0 3.1 1.8 -1.7
Heel T-Score 6.3 49.9 70.2 8.4 -5.4
BMI 0.5 3.1 4.8 -2.2 1.2
Height 0.1 1.1 1.1 -1.0 1.1
Waist Hip Ratio (WHR) 0.0 0.0 0.0 -0.1 -0.1
Systolic Blood Pressure 0.7 3.7 4.2 2.0 -1.8
Smoking Status 0.1 0.3 0.4 -0.6 0.3
Allergy or Eczema 0.6 1.6 3.1 1.8 -0.4
Cardiovascular Disease 0.1 0.2 0.2 -0.4 -0.5
Hypothyroidism (self reported) 0.2 0.5 0.7 -0.6 0.8
Respiratory disease 0.2 0.4 0.7 -0.3 0.8
Type 2 Diabetes (T2D) (2018) 0.8 1.6 2.0 1.1 -1.4
Lung FEV1/FVC ratio 0.1 0.7 1.1 0.6 -1.1
Lung FVC 0.5 2.4 4.5 2.1 -0.6
Neuroticism 0.1 0.2 0.4 -0.6 0.1
Chronotype (morning person) 0.3 0.6 0.9 0.6 0.9
Hair Pigment 0.0 0.6 0.6 0.7 -0.8
Tanning 0.1 0.9 0.9 -0.9 1.0
Hand grip strength (left) 0.5 1.2 1.9 0.7 1.4
Number of treatments/medications taken 1.2 2.2 2.6 1.4 -1.6
Average weekly spirits intake 0.2 0.3 0.6 0.8 0.2
Sensitivity / hurt feelings 0.2 0.3 0.4 0.6 0.4
Frequency of depressed mood in last 2 weeks 0.3 0.4 0.6 -0.8 -0.3
Hearing difficulty/problems: Yes 1.5 2.3 2.4 1.5 -1.5
Relative age of first facial hair 0.5 1.1 1.5 -1.2 0.9
Other serious medical condition/disability diagnosed by doctor 0.1 0.1 0.3 -0.5 0.0
Ever used hormone-replacement therapy (HRT) 3.0 3.8 7.4 2.7 -0.5
Ever had hysterectomy (womb removed) 0.4 0.4 0.6 0.5 -0.8
Systolic blood pressure, automated reading 1.8 5.4 5.8 2.2 -2.4
Eye problems/disorders: Diabetes related eye disease 1.9 2.1 3.7 1.9 -0.8
Angina 1.0 1.3 1.9 -1.4 0.8
Medication for hormone replacement therapy 0.2 0.2 0.3 0.3 0.5
Vitamin and mineral supplements 1.0 1.4 2.3 0.7 -1.5
Supplements: Zinc 1.7 1.8 2.8 -0.9 1.7
Medication: Co-codamol 0.5 0.6 1.2 0.2 -1.1
Medication: Metformin 0.7 1.0 1.2 1.1 -0.8
Diabetes (father) 0.3 0.3 0.5 -0.4 0.7
Diabetes (mother) 0.2 0.3 0.3 -0.4 0.6
Severe depression (siblings) 0.6 0.7 1.4 -1.2 -0.0
Pack years adult smoking proportion 0.1 0.2 0.4 -0.6 -0.0
Impedance of leg (right) 0.2 0.9 1.7 1.3 -0.3
Leg fat-free mass (left) 0.7 3.7 6.2 -2.5 1.2
Trunk fat percentage 0.1 0.5 1.1 -1.0 -0.2
Hand grip strength (right) 0.4 1.2 2.3 0.3 1.5
Townsend deprivation index at recruitment 0.2 0.3 0.4 -0.6 -0.6
Current tobacco smoking 2.0 3.3 4.7 -1.4 2.2
Average weekly fortified wine intake 0.3 0.3 0.7 0.1 0.8
Maternal smoking around birth 0.1 0.2 0.3 -0.1 -0.6
Fed-up feelings 1.3 2.3 3.2 1.2 -1.8
Frequency of unenthusiasm / disinterest in last 2 weeks 1.2 1.6 2.4 -1.5 0.9
Relative age voice broke 0.4 0.6 1.1 -0.2 1.1
Taking other prescription medications 3.2 4.9 7.1 1.7 -2.7
Age when periods started (menarche) 0.5 1.2 2.5 -1.6 -0.0
Bilateral oophorectomy (both ovaries removed) 0.4 0.5 1.0 -0.2 1.0
Heel bone mineral density (BMD) T-score, automated (left) 4.8 10.8 16.8 4.1 -2.2
Tinnitus: Yes, but not now, but have in the past 0.1 0.1 0.1 0.3 0.4
Qualifications: CSEs or equivalent 0.0 0.0 0.0 -0.0 -0.1
Serious illness, injury or assault to yourself 1.1 1.3 2.6 -1.6 0.3
High blood pressure 1.7 4.8 5.5 2.0 -2.3
Hayfever, allergic rhinitis or eczema 0.2 0.5 0.9 1.0 0.2
Multivitamins +/- minerals 0.6 0.8 1.5 -0.3 1.2
Stomach or abdominal pain in last month 0.4 0.5 1.0 -1.0 0.2
Supplements: Glucosamine 0.5 0.7 0.7 0.9 0.8
Diverticular disease/diverticulitis (self-reported) 0.7 0.9 1.5 0.5 -1.2
Medication: Atenolol 0.1 0.1 0.2 0.1 -0.4
Medication: Levothyroxine sodium 0.0 0.0 0.0 -0.1 -0.1
Sitting height 0.1 0.8 1.6 1.3 -0.2
Chronic bronchitis/emphysema (father) 0.3 0.4 0.6 -0.5 -0.7
High blood pressure (mother) 2.1 3.0 3.5 1.9 -1.6
Body mass index (BMI) 0.1 0.4 0.9 -0.9 0.1
Impedance of leg (left) 0.3 1.7 3.1 1.8 -0.6
Leg predicted mass (left) 0.7 3.7 6.1 -2.5 1.2
Trunk fat mass 0.3 1.2 2.4 -1.5 0.3
Waist circumference 0.6 2.3 4.3 -2.1 0.6
Number of incorrect matches in round 0.0 0.1 0.1 -0.1 0.3
Past tobacco smoking 0.2 0.4 0.6 0.4 0.8
Alcohol usually taken with meals 0.1 0.1 0.2 0.4 -0.0
Nervous feelings 0.0 0.1 0.1 -0.4 0.1
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.7 1.1 -0.6 -1.0
Hearing difficulty/problems with background noise 0.3 0.5 0.9 0.9 -0.4
Hair/balding pattern: Pattern 2 1.8 2.3 2.6 1.6 -1.4
Had menopause 0.1 0.1 0.2 -0.0 0.5
Had other major operations 0.8 0.9 1.1 -1.1 0.9
Forced vital capacity (FVC) 0.1 0.4 0.7 -0.1 0.8
Heel bone mineral density (BMD) T-score, automated (right) 7.9 18.2 22.6 4.7 -3.7
Ever unenthusiastic/disinterested for a whole week 2.8 3.5 4.1 -2.0 1.7
Qualifications: None of the above 0.1 0.2 0.3 -0.2 0.5
Financial difficulties in last 2 years 0.4 0.5 0.9 -1.0 0.2
Mouth/teeth dental problems 5.3 8.2 10.1 3.2 -2.5
Heart attack 0.5 0.6 1.3 -1.1 0.1
Allergy 0.1 0.2 0.3 -0.6 -0.3
Pain all over the body in last month 1.0 1.0 2.1 -1.4 0.1
Diabetes (self-reported) 2.0 3.1 3.7 1.6 -1.9
Hayfever/allergic rhinitis (self-reported) 0.7 1.0 1.8 1.3 -0.4
Medication: Ramipril 0.6 0.7 1.2 0.5 -1.1
Medication: Simvastatin 0.5 0.7 0.8 -0.8 0.9
Fluid intelligence score 0.8 1.7 1.9 -1.2 1.4
Illnesses of siblings 0.6 0.9 1.5 -0.5 1.2
Neuroticism score 0.1 0.2 0.4 -0.6 0.2
Weight 0.5 2.3 3.5 -1.9 1.0
Impedance of arm (right) 0.2 1.0 1.6 0.7 -1.3
Arm fat percentage (right) 0.2 0.7 1.3 -1.2 -0.3
Trunk fat-free mass 0.7 3.9 5.0 -2.2 1.6
Hip circumference 0.7 2.8 5.0 -2.2 0.8
Time employed in main current job 1.0 1.1 2.1 0.4 1.4
Alcohol intake versus 10 years previously 0.9 1.4 1.5 -1.1 -1.2
Father’s age at death 0.0 0.1 0.1 0.2 -0.3
Worrier / anxious feelings 0.2 0.3 0.5 -0.2 0.7
Frequency of tiredness / lethargy in last 2 weeks 0.7 1.1 2.2 -1.5 0.1
Falls in the last year 0.0 0.0 0.1 0.3 0.2
Hair/balding pattern: Pattern 3 0.9 1.3 1.8 -1.4 0.9
Number of live births 0.1 0.2 0.3 0.5 0.2
Forced expiratory volume in 1-second (FEV1) 0.1 0.2 0.3 0.6 0.1
Pulse rate 0.3 0.5 1.1 -0.1 1.0
Happiness 0.0 0.0 0.1 0.2 -0.3
Noisy workplace 0.0 0.0 0.0 0.1 0.1
Qualifications: A levels/AS levels or equivalent 0.5 1.0 2.1 -1.4 -0.0
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.1 0.1 0.0 -0.4
Mouth/teeth dental problems: Dentures 0.2 0.4 0.4 -0.6 0.6
Asthma 0.2 0.4 0.7 0.3 0.8
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.4 0.7 0.9 -0.2
Medication: Cholesterol lowering 0.1 0.2 0.4 -0.6 0.3
Depression (self-reported) 0.3 0.4 0.7 0.9 -0.3
Medication: Lansoprazole 1.4 1.6 2.1 1.4 -1.0
Prospective memory result 2.5 3.1 4.7 -2.2 1.2
Lung cancer (father) 0.1 0.2 0.3 0.0 -0.6
Illnesses of mother 0.6 0.8 1.5 -1.2 0.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.0 0.1 0.2 0.4 0.2
Pulse wave Arterial Stiffness index 0.0 0.0 0.0 0.1 -0.1
Impedance of arm (left) 0.3 1.5 2.0 1.0 -1.4
Arm fat mass (right) 0.3 1.3 2.5 -1.6 0.2
Trunk predicted mass 0.6 3.6 4.7 -2.2 1.6
Standing height 0.3 3.0 3.4 -1.8 1.6
Length of working week for main job 0.9 1.0 1.7 -0.6 1.3
Exposure to tobacco smoke at home 0.2 0.2 0.4 -0.1 -0.6
Breastfed as a baby 1.8 2.2 3.2 -1.1 1.8
Tense / ‘highly strung’ 0.1 0.2 0.4 0.6 -0.1
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.5 0.6 -0.8 -0.6
Hair/balding pattern: Pattern 4 0.7 1.6 2.1 -1.4 1.1
Birth weight of first child 1.2 2.1 4.3 0.1 2.1
Peak expiratory flow (PEF) 0.1 0.2 0.2 0.4 -0.5
Pulse wave reflection index 1.1 1.3 2.3 -1.5 0.6
Ever highly irritable/argumentative for 2 days 1.8 2.1 3.8 -2.0 0.6
Loud music exposure frequency 2.3 2.6 3.5 -1.9 1.3
Qualifications: O levels/GCSEs or equivalent 0.4 0.7 1.1 0.5 -1.1
Mouth/teeth dental problems: Bleeding gums 4.3 5.5 7.1 -2.7 2.0
Blood clot in the leg (DVT) 1.3 1.7 2.1 -1.4 1.1
Medication: Paracetamol 0.1 0.1 0.2 0.1 0.5
Headache pain in last month 0.5 0.9 1.3 -0.7 1.2
Medication for cholesterol, blood pressure or diabetes 1.6 2.6 2.8 -1.7 1.5
Glaucoma (self-reported) 3.0 3.5 3.6 1.9 -1.9
Gout (self-reported) 2.8 3.8 5.3 1.5 -2.3
Hypothyroidism/myxoedema (self-reported) 0.5 0.9 1.0 -1.0 0.9
Medication: Amlodipine 11.2 15.7 18.8 4.3 -3.6
Medication: Ventolin 100micrograms inhaler 0.6 0.8 0.8 0.9 -0.9
Birth weight 0.3 0.7 0.7 -0.8 0.8
Chronic bronchitis/emphysema (mother) 0.6 0.7 1.3 -0.4 1.1
High blood pressure (siblings) 2.6 3.8 6.0 1.3 -2.4
Forced vital capacity (FVC), Best measure 0.0 0.2 0.3 0.2 0.5
Body fat percentage 0.1 0.6 1.2 -1.1 0.1
Leg fat percentage (right) 0.3 1.2 1.6 -1.3 0.9
Arm fat-free mass (right) 0.5 2.8 3.2 -1.8 1.5
Exposure to tobacco smoke outside home 0.2 0.2 0.4 0.1 -0.7
Comparative body size at age 10 0.4 1.1 2.3 1.5 0.2
Number of full brothers 0.8 1.0 1.0 -1.0 1.0
Worry too long after embarrassment 0.8 1.3 1.5 1.2 -1.0
Seen a psychiatrist for nerves, anxiety, tension or depression 0.7 1.0 1.2 -1.1 0.9
Wheeze or whistling in the chest in last year 0.6 1.1 1.7 -1.3 0.8
Number of children fathered 0.7 0.8 0.9 0.9 -0.8
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.2 0.2 0.4 0.5
Age at first live birth 0.7 1.2 1.7 1.3 -0.9
Pulse wave peak to peak time 0.0 0.0 0.1 -0.2 0.2
Health satisfaction 3.0 3.9 5.0 -2.2 1.7
Shortness of breath walking on level ground 0.6 0.7 1.3 -1.1 -0.3
Qualifications: College or University degree 0.0 0.1 0.1 0.3 0.4
Eye problems/disorders: None of the above 0.6 0.7 1.0 -0.6 1.0
Mouth/teeth dental problems: Loose teeth 1.3 1.5 1.6 -1.2 1.3
Emphysema/chronic bronchitis 0.1 0.1 0.3 0.0 -0.5
Medication for pain relief, constipation, heartburn 0.1 0.2 0.4 -0.3 0.6
Neck or shoulder pain in last month 0.0 0.1 0.1 -0.3 -0.1
Medication: Blood pressure 4.5 8.0 9.5 2.6 -3.1
Angina (self-reported) 0.6 0.8 1.1 -1.0 0.7
Migraine (self-reported) 1.2 1.5 2.8 1.7 -0.4
Medication: Ibuprofen 0.5 0.6 0.6 0.8 -0.8
Medication: Allopurinol 1.4 1.8 2.7 1.0 -1.6
Medication: Omeprazole 1.3 1.5 3.0 0.1 -1.7
Medication: Seretide 50 evohaler 0.0 0.0 0.0 -0.2 0.2
Mean time to correctly identify matches 0.4 0.8 1.6 -1.3 -0.1
Heart disease (mother) 0.1 0.2 0.2 -0.3 0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.3 0.4 -0.6 0.5
Whole body fat mass 0.4 1.9 3.4 -1.8 0.6
Leg fat mass (right) 0.3 1.3 2.3 -1.5 0.6
Arm predicted mass (right) 0.7 3.8 4.4 -2.1 1.8
Pulse rate, automated reading 0.2 0.8 1.6 0.1 1.2
Alcohol intake frequency. 1.9 4.4 8.7 -3.0 0.3
Comparative height size at age 10 0.1 0.6 0.8 -0.7 0.9
Number of full sisters 0.2 0.2 0.3 -0.3 0.5
Suffer from ‘nerves’ 0.0 0.1 0.1 0.1 -0.4
Overall health rating 0.4 0.9 1.7 -1.3 0.1
Chest pain or discomfort 0.8 1.1 1.6 -0.8 -1.2
Had major operations 0.8 0.9 1.1 1.1 -0.9
Age at last live birth 0.6 0.9 1.4 1.2 -0.6
Family relationship satisfaction 1.0 1.2 1.3 -1.0 1.1
Leg pain on walking 4.2 5.2 5.5 -2.2 2.3
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.4 0.6 0.8 -0.5
Commuting to job workplace: Car/motor vehicle 0.2 0.2 0.4 0.2 -0.6
Illness, injury, bereavement, stress in last 2 years 0.6 0.7 0.8 0.8 -0.9
Medication: Aspirin 0.1 0.1 0.3 0.5 0.2
Supplements: Vitamin C 0.6 0.7 0.9 -1.0 0.6
Knee pain experienced in last month 0.0 0.0 0.0 0.2 0.2
Hypertension (Self-reported) 2.1 6.0 6.7 2.3 -2.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 0.6 0.8 -0.8
Illnesses of father: Heart disease 0.0 0.0 0.0 -0.1 0.2
Illnesses of siblings: Diabetes 0.2 0.3 0.4 0.6 0.4
Smoking status: Previous 0.4 0.7 1.0 -0.5 -1.0
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.7 1.3 -1.1 0.2
Whole body fat-free mass 0.7 4.2 6.0 -2.5 1.6
Leg fat-free mass (right) 0.5 2.8 4.5 -2.1 1.0
Arm fat percentage (left) 0.1 0.6 1.0 -1.0 -0.3
Average weekly red wine intake 0.5 0.8 1.6 1.3 0.1
Handedness (chirality/laterality): Left-handed 1.2 1.4 2.9 -0.2 1.7
Mood swings 0.2 0.4 0.8 0.2 -0.9
Loneliness, isolation 0.1 0.2 0.2 0.4 -0.3
Long-standing illness, disability or infirmity 0.3 0.5 0.9 0.3 -0.9
Ever had bowel cancer screening 0.1 0.1 0.2 -0.4 0.3
Diabetes diagnosed by doctor 1.7 2.8 3.1 1.5 -1.8
Ever had stillbirth, spontaneous miscarriage or termination 2.5 2.6 3.0 -1.5 1.7
Friendships satisfaction 0.0 0.1 0.1 -0.1 0.3
Qualifications: nursing, teaching 0.9 1.4 2.0 1.4 -0.9
Commuting to job workplace: Walk 0.6 0.6 1.3 1.1 -0.2
Eye problems/disorders: Cataract 0.4 0.4 0.5 -0.7 -0.6
Mouth/teeth dental problems: Mouth ulcers 0.4 0.6 0.6 -0.8 0.8
Medication for cholesterol 0.7 1.1 1.2 1.0 -1.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.9 1.0 1.5 -1.2 0.8
Back pain experienced in last month 0.4 0.5 1.0 -1.0 0.2
Mineral and other dietary supplements 0.7 1.0 1.1 -1.1 -0.9
Breast cancer (self-reported) 1.1 1.4 2.7 -1.6 0.1
Asthma (self-reported) 0.2 0.4 0.6 0.4 0.8
Osteoporosis (self-reported) 0.7 0.8 1.0 -1.0 -0.8
Osteoarthritis (self-reported) 0.0 0.0 0.1 0.3 -0.0
Medication: Aspirin 0.1 0.1 0.3 0.5 -0.1
Medication: Gliclazide 0.8 0.9 1.0 -0.8 1.0
Illnesses of father: None of the above (group 1) 0.7 0.8 1.4 -0.6 1.2
Smoking status: Current 2.0 3.1 4.1 -1.4 2.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.0 2.2 4.4 2.1 0.1
Whole body water mass 0.8 4.4 6.1 -2.5 1.7
Leg predicted mass (right) 0.5 2.9 4.7 -2.2 1.0
Arm fat mass (left) 0.3 1.3 2.4 -1.6 0.4
Number of self-reported non-cancer illnesses 0.8 1.3 1.7 1.0 -1.3
Average weekly champagne plus white wine intake 0.2 0.2 0.5 -0.7 0.1
Miserableness 0.1 0.1 0.2 0.5 -0.0
Guilty feelings 0.1 0.2 0.4 -0.2 -0.6
Wears glasses or contact lenses 2.0 2.3 2.8 1.7 -1.3
Ever taken oral contraceptive pill 3.9 4.4 5.3 -1.9 2.3
Hearing aid user 0.5 0.5 0.6 0.6 -0.8
Mother’s age at death 0.1 0.1 0.2 0.3 -0.5
Financial situation satisfaction 0.2 0.3 0.4 -0.5 0.6
Tinnitus: Yes, now most or all of the time 0.2 0.3 0.5 -0.1 -0.7
Commuting to job workplace: Public transport 0.6 0.7 0.8 -0.9 0.8
Eye problems/disorders: Glaucoma 2.8 3.3 6.0 2.4 -0.8
Medication: Blood pressure 0.0 0.0 0.0 0.2 0.1
Pain type(s) experienced in last month: Hip pain 0.0 0.0 0.0 -0.0 -0.1
Supplements: Fish oil (including cod liver oil) 1.4 1.8 3.5 1.9 0.2
High cholesterol (Self-reported) 3.5 6.1 9.1 -3.0 1.8
Medication: Bendroflumethiazide 2.2 3.3 5.5 2.4 -1.1
Medication: Paracetamol 0.1 0.1 0.1 0.3 -0.3
Medication: Lisinopril 0.0 0.0 0.0 0.2 0.1
Medication: Atorvastatin 1.3 1.6 3.0 -1.7 0.4
Illnesses of father: High blood pressure 1.3 1.6 2.8 1.7 -0.6
Alcohol drinker status: Never 3.5 4.2 4.7 -1.9 2.2
Ever smoked 0.4 0.7 1.3 0.3 -1.1
Basal metabolic rate 0.7 3.7 5.2 -2.3 1.4
Leg fat percentage (left) 0.2 0.8 1.0 -1.0 0.7
Arm fat-free mass (left) 0.7 3.4 3.9 -2.0 1.7
Number of operations (self-reported) 0.6 0.9 1.1 -1.0 0.9
Average weekly beer plus cider intake 0.3 0.4 0.5 0.6 0.7
Irritability 0.0 0.1 0.1 -0.3 0.2
Risk taking 0.8 1.2 1.6 -1.3 0.9
Ever had prostate specific antigen (PSA) test 1.5 1.8 2.4 1.6 -1.1
Fractured/broken bones in last 5 years 0.5 0.7 1.2 -1.1 0.4
Age started oral contraceptive pill 0.1 0.2 0.3 0.2 0.5
Diastolic blood pressure, automated reading 0.9 2.7 2.9 1.6 -1.7
Ever depressed for a whole week 1.5 1.9 3.4 -1.9 0.6
Unable to work because of sickness or disability 0.2 0.2 0.5 -0.0 -0.7
Commuting to job workplace: Cycle 1.8 2.2 4.0 -2.0 0.5
Myopia 0.2 0.3 0.6 -0.2 -0.8
Vascular/heart problems diagnosed by doctor 1.2 3.4 3.6 -1.8 1.9
Cholesterol lowering medication 3.8 5.7 8.9 -3.0 1.5
Medication: Omeprazole (e.g. Zanprol) 1.7 2.1 3.9 0.5 -2.0
Pain experienced in last month 1.7 2.9 3.7 1.9 -1.4
Supplements: Calcium 2.0 2.2 2.8 -1.7 1.3
Basal cell carcinoma (self-reported) 0.7 0.9 1.3 -1.1 -0.7
Heart attack/myocardial infarction (self-reported) 0.5 0.7 1.3 -1.2 0.1
Deep venous thrombosis (DVT) (self-reported) 1.0 1.3 1.7 -1.3 0.9
Heart disease (siblings) 0.7 0.8 1.5 -1.2 0.3
Alcohol drinker status: Previous 3.0 3.4 5.7 1.1 -2.4
Pack years of smoking 0.3 0.4 0.7 -0.8 0.3
Impedance of whole body 0.3 1.3 1.6 1.3 -1.0
Leg fat mass (left) 0.3 1.0 1.8 -1.3 0.5
Arm predicted mass (left) 0.7 3.7 4.1 -2.0 1.8