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chr3:51,616,334-53,778,875

Best TWAS P=3.14e-12 · Best GWAS P=3.48e-12 conditioned to 0.136

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	GLT8D1	0.07	0.10	lasso	1	0.09	5.2e-11	6.3	6.3	3.5e-10	0.88	0.24	0.76	FALSE
2	CommonMind	Brain Pre-frontal Cortex	NEK4	0.07	0.11	enet	69	0.11	1.0e-13	6.2	-6.7	2.0e-11	-0.93	0.14	0.86	FALSE
3	GTEx	Adipose Subcutaneous	NEK4	0.04	0.01	lasso	3	0.00	1.2e-01	6.1	-6.3	2.9e-10	-0.89	0.17	0.74	FALSE
4	GTEx	Adipose Visceral Omentum	NEK4	0.10	0.09	lasso	3	0.08	5.0e-05	6.3	-6.0	2.0e-09	-0.87	0.22	0.77	FALSE
5	GTEx	Adipose Visceral Omentum	RP5-966M1.6	0.18	0.12	lasso	12	0.09	1.6e-05	4.9	5.2	2.6e-07	0.60	0.92	0.07	FALSE
6	GTEx	Artery Aorta	GNL3	0.12	0.15	lasso	5	0.14	4.7e-08	6.2	-6.8	8.1e-12	-0.85	0.21	0.78	FALSE
7	GTEx	Artery Aorta	NT5DC2	0.08	0.10	lasso	2	0.06	3.4e-04	-6.7	6.7	1.7e-11	0.83	0.03	0.94	FALSE
8	GTEx	Artery Aorta	TMEM110	0.19	0.08	enet	16	0.10	6.0e-06	4.9	6.2	6.4e-10	0.74	0.58	0.40	FALSE
9	GTEx	Artery Aorta	ITIH4-AS1	0.38	0.45	lasso	10	0.42	1.4e-24	4.9	5.3	1.2e-07	0.62	1.00	0.00	FALSE
10	GTEx	Artery Aorta	MUSTN1	0.15	0.14	lasso	6	0.11	9.5e-07	4.9	5.6	2.0e-08	0.68	0.90	0.10	FALSE
11	GTEx	Artery Coronary	TMEM110	0.17	0.05	lasso	8	0.07	3.1e-03	-4.8	6.4	1.3e-10	0.68	0.16	0.36	FALSE
12	GTEx	Artery Tibial	NEK4	0.11	0.10	enet	11	0.12	2.1e-09	-5.7	-5.3	1.4e-07	-0.78	0.32	0.68	FALSE
13	GTEx	Artery Tibial	GNL3	0.08	0.06	lasso	3	0.06	3.0e-05	-5.9	-5.8	5.2e-09	-0.72	0.20	0.79	FALSE
14	GTEx	Artery Tibial	PBRM1	0.16	0.20	enet	35	0.21	4.8e-16	6.2	6.4	1.6e-10	0.83	0.29	0.71	FALSE
15	GTEx	Brain Cerebellar Hemisphere	GNL3	0.13	0.19	enet	16	0.10	1.6e-03	6.1	-6.3	4.0e-10	-0.86	0.21	0.71	FALSE
16	GTEx	Brain Cerebellum	GNL3	0.14	0.07	enet	43	0.09	1.3e-03	6.2	-6.6	3.1e-11	-0.85	0.16	0.75	FALSE
17	GTEx	Brain Frontal Cortex BA9	GNL3	0.14	0.15	enet	10	0.13	2.3e-04	-6.4	-5.7	1.2e-08	-0.66	0.07	0.66	FALSE
18	GTEx	Brain Hippocampus	GLYCTK	0.17	0.16	lasso	7	0.10	2.6e-03	6.0	-6.1	1.1e-09	-0.86	0.13	0.50	FALSE
19	GTEx	Brain Hippocampus	TMEM110	0.17	0.11	lasso	7	0.13	5.1e-04	5.9	5.9	4.7e-09	0.75	0.07	0.30	FALSE
20	GTEx	Brain Hippocampus	GLYCTK-AS1	0.17	0.25	lasso	6	0.15	1.9e-04	6.2	-6.2	4.5e-10	-0.84	0.16	0.68	FALSE
21	GTEx	Brain Nucleus accumbens basal ganglia	TMEM110	0.13	0.07	lasso	3	0.05	1.5e-02	5.9	5.3	1.0e-07	0.76	0.08	0.44	FALSE
22	GTEx	Brain Putamen basal ganglia	ITIH4-AS1	0.18	0.00	enet	23	0.06	1.8e-02	5.3	5.2	2.0e-07	0.53	0.10	0.14	FALSE
23	GTEx	Breast Mammary Tissue	NEK4	0.06	0.03	enet	7	0.06	7.8e-04	-6.7	-5.5	4.4e-08	-0.67	0.09	0.66	FALSE
24	GTEx	Breast Mammary Tissue	NT5DC2	0.13	0.12	enet	11	0.08	9.9e-05	-5.4	-5.9	3.8e-09	-0.67	0.22	0.71	FALSE
25	GTEx	Breast Mammary Tissue (Female)	NT5DC2	0.09	0.08	lasso	1	0.06	5.9e-03	-5.4	-5.4	5.2e-08	-0.68	0.06	0.26	FALSE
26	GTEx	Cells EBV-transformed lymphocytes	NT5DC2	0.18	0.29	lasso	1	0.28	6.6e-10	-6.7	-6.7	2.6e-11	-0.83	0.03	0.97	FALSE
27	GTEx	Cells EBV-transformed lymphocytes	RP5-966M1.6	0.16	0.07	enet	19	0.11	1.8e-04	4.5	5.9	3.7e-09	0.73	0.35	0.58	FALSE
28	GTEx	Cells Transformed fibroblasts	SPCS1	0.22	0.03	lasso	2	0.01	9.4e-02	6.0	5.9	3.5e-09	0.84	0.11	0.32	FALSE
29	GTEx	Cells Transformed fibroblasts	NEK4	0.07	0.11	lasso	5	0.08	7.2e-07	-6.5	-6.8	1.5e-11	-0.86	0.10	0.90	FALSE
30	GTEx	Cells Transformed fibroblasts	GNL3	0.10	0.12	lasso	8	0.10	3.0e-08	6.2	-6.3	3.8e-10	-0.88	0.27	0.73	FALSE
31	GTEx	Cells Transformed fibroblasts	PBRM1	0.03	0.04	lasso	3	0.02	1.6e-02	-4.0	-5.3	8.6e-08	-0.75	0.13	0.64	FALSE
32	GTEx	Cells Transformed fibroblasts	WDR82	0.05	0.02	lasso	5	0.02	1.8e-02	6.0	6.4	1.3e-10	0.83	0.10	0.76	FALSE
33	GTEx	Cells Transformed fibroblasts	NT5DC2	0.30	0.17	enet	23	0.18	1.3e-13	-6.7	-5.7	1.2e-08	-0.78	0.02	0.98	FALSE
34	GTEx	Colon Sigmoid	GNL3	0.08	0.04	lasso	5	0.04	1.8e-02	6.2	-6.2	4.4e-10	-0.88	0.11	0.52	FALSE
35	GTEx	Colon Sigmoid	NT5DC2	0.08	0.07	enet	8	0.06	4.5e-03	-6.6	-6.2	5.5e-10	-0.78	0.07	0.70	FALSE
36	GTEx	Colon Transverse	NT5DC2	0.12	0.18	lasso	12	0.17	1.6e-08	-6.7	-6.9	4.7e-12	-0.89	0.03	0.97	FALSE
37	GTEx	Esophagus Mucosa	NEK4	0.05	0.03	lasso	8	0.02	2.4e-02	-4.0	-5.9	3.7e-09	-0.77	0.14	0.80	FALSE
38	GTEx	Esophagus Mucosa	RP5-966M1.6	0.11	0.14	lasso	4	0.14	9.5e-10	4.9	5.2	2.4e-07	0.62	0.95	0.05	FALSE
39	GTEx	Esophagus Muscularis	GNL3	0.06	0.12	lasso	1	0.10	1.5e-06	-5.9	-5.9	3.7e-09	-0.72	0.25	0.74	FALSE
40	GTEx	Heart Atrial Appendage	GLYCTK	0.08	0.02	lasso	5	0.00	3.0e-01	-4.3	-6.0	2.5e-09	-0.83	0.15	0.69	FALSE
41	GTEx	Heart Atrial Appendage	NT5DC2	0.07	0.09	lasso	1	0.06	1.2e-03	-6.5	6.5	1.0e-10	0.81	0.08	0.84	FALSE
42	GTEx	Heart Atrial Appendage	GLYCTK-AS1	0.06	-0.01	lasso	2	0.00	6.1e-01	-4.3	-5.9	4.7e-09	-0.82	0.11	0.63	FALSE
43	GTEx	Lung	NEK4	0.05	0.01	lasso	3	0.00	2.1e-01	6.4	-6.2	4.9e-10	-0.86	0.08	0.89	FALSE
44	GTEx	Lung	GNL3	0.05	0.03	lasso	6	0.03	3.0e-03	6.2	-6.3	2.8e-10	-0.83	0.14	0.80	FALSE
45	GTEx	Lung	TMEM110	0.13	0.10	lasso	7	0.07	8.4e-06	5.3	5.9	4.6e-09	0.60	0.99	0.01	FALSE
46	GTEx	Lung	GLYCTK-AS1	0.11	0.09	lasso	5	0.09	3.0e-07	-4.3	-5.3	1.1e-07	-0.72	0.62	0.38	FALSE
47	GTEx	Muscle Skeletal	ITIH4-AS1	0.06	0.03	lasso	4	0.06	2.3e-06	4.9	5.9	4.7e-09	0.73	0.32	0.67	FALSE
48	GTEx	Nerve Tibial	NEK4	0.06	0.06	enet	8	0.06	2.2e-05	6.6	-6.5	5.8e-11	-0.90	0.11	0.89	FALSE
49	GTEx	Nerve Tibial	NT5DC2	0.09	0.04	enet	17	0.05	2.1e-04	6.6	-6.2	6.2e-10	-0.87	0.04	0.96	FALSE
50	GTEx	Nerve Tibial	ITIH4-AS1	0.19	0.22	lasso	3	0.21	1.5e-14	5.3	5.3	1.3e-07	0.58	0.99	0.01	FALSE
51	GTEx	Pituitary	SFMBT1	0.16	0.01	enet	9	0.02	1.2e-01	6.2	6.2	4.3e-10	0.80	0.15	0.36	FALSE
52	GTEx	Skin Not Sun Exposed Suprapubic	NT5DC2	0.23	0.10	lasso	4	0.09	8.3e-06	6.6	-6.5	8.3e-11	-0.99	0.01	0.99	FALSE
53	GTEx	Skin Sun Exposed Lower leg	NEK4	0.06	0.12	lasso	3	0.10	2.2e-08	6.3	-6.4	1.6e-10	-0.88	0.14	0.86	FALSE
54	GTEx	Skin Sun Exposed Lower leg	NT5DC2	0.21	0.19	enet	12	0.18	2.0e-14	6.6	-6.5	9.6e-11	-0.99	0.01	0.99	FALSE
55	GTEx	Skin Sun Exposed Lower leg	ITIH4-AS1	0.15	0.11	enet	28	0.11	2.4e-09	5.3	5.8	8.7e-09	0.66	0.97	0.03	FALSE
56	GTEx	Skin Sun Exposed Lower leg	RP5-966M1.6	0.16	0.17	lasso	3	0.16	2.0e-13	5.3	5.2	2.0e-07	0.58	1.00	0.00	FALSE
57	GTEx	Small Intestine Terminal Ileum	RP5-966M1.6	0.14	0.03	lasso	7	0.00	2.5e-01	6.2	6.3	2.3e-10	0.81	0.08	0.33	FALSE
58	GTEx	Stomach	RP5-966M1.6	0.15	0.20	enet	14	0.20	7.0e-10	4.9	5.4	6.8e-08	0.65	0.93	0.07	FALSE
59	GTEx	Testis	GNL3	0.12	0.18	lasso	7	0.18	2.4e-08	6.2	-6.5	1.0e-10	-0.86	0.19	0.81	FALSE
60	GTEx	Testis	NT5DC2	0.11	0.16	enet	8	0.11	1.0e-05	-6.7	-6.8	1.0e-11	-0.86	0.03	0.97	FALSE
61	GTEx	Thyroid	NEK4	0.09	0.09	lasso	4	0.10	4.1e-08	6.3	-6.3	3.5e-10	-0.87	0.27	0.73	FALSE
62	GTEx	Thyroid	PBRM1	0.19	0.33	lasso	7	0.31	2.7e-24	5.9	6.2	7.6e-10	0.90	0.33	0.67	FALSE
63	GTEx	Thyroid	NT5DC2	0.20	0.13	lasso	3	0.13	4.0e-10	-6.7	-7.0	3.1e-12	-0.91	0.02	0.98	TRUE
64	GTEx	Thyroid	ITIH4-AS1	0.31	0.24	lasso	8	0.27	1.6e-20	4.9	5.1	2.7e-07	0.58	1.00	0.00	FALSE
65	GTEx	Whole Blood	SPCS1	0.03	0.02	lasso	3	0.02	4.6e-03	5.9	6.0	1.8e-09	0.79	0.12	0.85	FALSE
66	GTEx	Whole Blood	TMEM110	0.15	0.08	lasso	7	0.07	5.7e-07	5.3	5.8	5.1e-09	0.63	0.99	0.01	FALSE
67	GTEx	Whole Blood	ITIH4-AS1	0.33	0.24	lasso	7	0.25	9.7e-23	4.9	5.5	5.2e-08	0.61	1.00	0.00	FALSE
68	GTEx	Whole Blood	RP5-966M1.6	0.20	0.22	lasso	6	0.22	1.4e-19	4.9	5.3	1.3e-07	0.59	1.00	0.00	FALSE
69	METSIM	Adipose	GNL3	0.04	0.06	enet	25	0.05	4.5e-08	6.3	-6.2	4.8e-10	-0.90	0.19	0.81	FALSE
70	METSIM	Adipose	ITIH4	0.35	0.24	bslmm	389	0.27	4.2e-41	4.9	5.9	3.1e-09	0.61	1.00	0.00	FALSE
71	METSIM	Adipose	NT5DC2	0.27	0.13	enet	34	0.14	2.2e-20	-6.7	-6.2	7.8e-10	-0.82	0.03	0.97	FALSE
72	METSIM	Adipose	PPM1M	0.08	0.08	enet	17	0.08	1.4e-12	5.8	-6.0	2.7e-09	-0.73	0.85	0.15	FALSE
73	NTR	Blood	ITIH4	0.05	0.05	lasso	7	0.04	2.5e-14	4.9	5.4	8.6e-08	0.59	1.00	0.00	FALSE
74	NTR	Blood	WDR82	0.02	0.03	blup	325	0.03	4.9e-09	-4.0	6.2	5.0e-10	0.79	0.32	0.68	FALSE
75	ROSMAP	Brain Pre-frontal Cortex	SPCS1	0.04	0.03	blup	357	0.04	6.6e-06	6.1	6.0	2.5e-09	0.87	0.16	0.83	FALSE
76	ROSMAP	Brain Pre-frontal Cortex	NEK4	0.04	0.05	blup	359	0.05	1.1e-06	-5.8	-6.0	1.7e-09	-0.72	0.22	0.78	FALSE
77	ROSMAP	Brain Pre-frontal Cortex	GNL3	0.15	0.23	enet	16	0.22	2.0e-28	-5.8	-6.0	1.4e-09	-0.77	0.81	0.19	FALSE
78	ROSMAP	Brain Pre-frontal Cortex	TMEM110	0.02	0.01	blup	321	0.02	9.7e-04	4.5	6.4	1.8e-10	0.78	0.16	0.58	FALSE
79	YFS	Blood	GNL3	0.02	0.03	enet	11	0.03	2.9e-09	6.3	-6.7	1.7e-11	-0.86	0.23	0.77	FALSE
80	YFS	Blood	NT5DC2	0.16	0.08	lasso	9	0.11	9.5e-35	6.6	-6.2	5.7e-10	-0.89	0.01	0.99	FALSE
81	YFS	Blood	SPCS1	0.04	0.03	enet	19	0.04	6.0e-12	6.4	5.3	9.4e-08	0.81	0.13	0.87	FALSE
82	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	ITIH4	0.04	0.03	blup	53	0.03	7.4e-04	4.9	6.0	1.6e-09	0.72	0.10	0.58	FALSE
83	The Cancer Genome Atlas	Breast Invasive Carcinoma	SPCS1	0.08	0.04	lasso	2	0.04	4.7e-08	-5.9	5.5	3.8e-08	0.64	0.27	0.73	FALSE
84	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	NEK4	0.07	0.01	blup	69	0.04	5.8e-03	6.2	-6.4	1.5e-10	-0.90	0.03	0.68	FALSE
85	The Cancer Genome Atlas	Colon Adenocarcinoma	ITIH4	0.08	0.09	blup	53	0.08	3.1e-05	5.3	5.2	2.1e-07	0.69	0.21	0.70	FALSE
86	The Cancer Genome Atlas	Colon Adenocarcinoma	NT5DC2	0.04	0.02	blup	50	0.03	9.7e-03	6.6	-6.5	1.0e-10	-0.95	0.02	0.74	FALSE
87	The Cancer Genome Atlas	Glioblastoma Multiforme	GNL3	0.17	0.06	blup	47	0.06	9.0e-03	6.1	-6.4	2.0e-10	-0.88	0.03	0.84	FALSE
88	The Cancer Genome Atlas	Glioblastoma Multiforme	ITIH4	0.10	0.02	blup	53	0.05	1.2e-02	4.9	6.0	2.5e-09	0.76	0.04	0.31	FALSE
89	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ITIH4	0.04	0.02	blup	53	0.03	3.0e-04	6.1	6.9	4.6e-12	0.87	0.02	0.94	FALSE
90	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GNL3	0.03	0.03	enet	6	0.04	3.6e-05	6.5	-6.3	2.1e-10	-0.90	0.02	0.97	FALSE
91	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ITIH4	0.06	0.06	blup	53	0.06	5.1e-07	4.9	5.7	1.0e-08	0.71	0.20	0.79	FALSE
92	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	NEK4	0.06	0.09	lasso	3	0.08	1.1e-09	6.3	-6.3	2.7e-10	-0.88	0.08	0.92	FALSE
93	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SFMBT1	0.40	0.17	lasso	6	0.17	1.9e-18	-4.8	5.3	1.0e-07	0.51	0.12	0.87	FALSE
94	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	GNL3	0.19	0.02	enet	9	0.04	2.0e-03	6.3	-5.5	4.5e-08	-0.74	0.04	0.91	FALSE
95	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	NEK4	0.07	0.04	blup	69	0.03	8.6e-03	6.3	-6.0	2.1e-09	-0.89	0.06	0.86	FALSE
96	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SFMBT1	0.17	0.14	lasso	6	0.14	2.5e-08	-4.8	5.5	4.1e-08	0.53	0.03	0.97	FALSE
97	The Cancer Genome Atlas	Brain Lower Grade Glioma	GNL3	0.15	0.08	enet	20	0.11	3.0e-12	6.6	-5.6	2.2e-08	-0.81	0.02	0.98	FALSE
98	The Cancer Genome Atlas	Lung Adenocarcinoma	ITIH4	0.07	0.06	enet	6	0.06	2.4e-07	4.9	5.2	1.7e-07	0.63	0.82	0.18	FALSE
99	The Cancer Genome Atlas	Lung Adenocarcinoma	SFMBT1	0.04	0.01	enet	3	0.03	2.1e-04	-5.4	-5.1	2.7e-07	-0.57	0.01	0.60	FALSE
100	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SPCS1	0.04	0.03	enet	1	0.03	2.9e-04	-5.9	5.9	3.7e-09	0.72	0.03	0.45	FALSE
101	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	ITIH4	0.05	0.02	blup	53	0.02	1.1e-02	4.9	5.6	2.4e-08	0.69	0.06	0.37	FALSE
102	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	LOC440957	0.04	0.02	blup	45	0.01	8.8e-02	-6.7	6.2	5.9e-10	0.78	0.02	0.70	FALSE
103	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	ITIH4	0.25	0.16	blup	53	0.15	1.6e-06	5.3	5.2	1.6e-07	0.64	0.40	0.49	FALSE
104	The Cancer Genome Atlas	Prostate Adenocarcinoma	GNL3	0.04	0.05	lasso	12	0.05	9.0e-06	6.1	-6.1	9.8e-10	-0.88	0.05	0.95	FALSE
105	The Cancer Genome Atlas	Prostate Adenocarcinoma	NEK4	0.13	0.07	lasso	4	0.06	4.0e-07	6.3	-6.1	1.3e-09	-0.85	0.08	0.92	FALSE
106	The Cancer Genome Atlas	Prostate Adenocarcinoma	NT5DC2	0.03	0.03	blup	51	0.03	6.1e-04	-6.7	-6.2	4.5e-10	-0.94	0.01	0.94	FALSE
107	The Cancer Genome Atlas	Rectum Adenocarcinoma	ITIH4	0.12	0.09	blup	53	0.06	1.4e-02	6.1	6.5	6.3e-11	0.85	0.02	0.72	FALSE
108	The Cancer Genome Atlas	Soft Tissue Sarcoma	GNL3	0.07	0.01	blup	47	0.03	1.1e-02	6.1	-5.6	2.2e-08	-0.81	0.03	0.62	FALSE
109	The Cancer Genome Atlas	Soft Tissue Sarcoma	NEK4	0.06	0.04	blup	69	0.03	8.2e-03	6.3	-6.1	9.1e-10	-0.88	0.04	0.69	FALSE
110	The Cancer Genome Atlas	Thyroid Carcinoma	GNL3	0.03	0.03	blup	47	0.03	3.3e-04	6.3	-6.2	4.3e-10	-0.89	0.03	0.96	FALSE
111	The Cancer Genome Atlas	Thyroid Carcinoma	NEK4	0.07	0.12	blup	69	0.12	6.3e-12	6.4	-6.7	2.1e-11	-0.90	0.04	0.96	FALSE
112	The Cancer Genome Atlas	Thyroid Carcinoma	NT5DC2	0.19	0.19	lasso	1	0.18	1.1e-17	-6.6	-6.6	5.3e-11	-0.82	0.04	0.96	FALSE
113	The Cancer Genome Atlas	Thyroid Carcinoma	PBRM1	0.15	0.14	enet	9	0.16	7.0e-15	-5.5	6.5	8.2e-11	0.86	0.07	0.93	FALSE