[Hub]/) : Traits : LDL Cholesterol : ← →

chr1:108,654,479-111,016,796

Best TWAS P=3.93e-172 · Best GWAS P=9.7e-171 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
39	GTEx	Whole Blood	PSRC1	0.14	0.04	lasso	3	0.03	6.9e-04	-27.900	-28.0	3.9e-172	1.00	0.00	1.00	TRUE
60	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	SORT1	0.23	0.16	lasso	4	0.16	4.6e-08	-27.900	-27.2	7.6e-163	0.94	0.00	1.00	TRUE
51	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	PSRC1	0.14	0.04	enet	13	0.07	2.7e-04	-27.800	-20.6	3.2e-94	0.73	0.01	0.74	TRUE
14	GTEx	Heart Atrial Appendage	RP5-1065J22.8	0.29	0.00	enet	29	0.11	1.5e-05	-4.400	-11.6	5.6e-31	0.41	0.06	0.15	TRUE
9	GTEx	Colon Sigmoid	TMEM167B	0.26	0.01	enet	37	0.01	1.4e-01	-6.280	8.6	1.1e-17	-0.16	0.18	0.18	TRUE
42	ROSMAP	Brain Pre-frontal Cortex	GSTM1	0.51	0.05	blup	434	0.26	1.4e-33	1.240	7.2	4.3e-13	-0.16	1.00	0.00	TRUE
19	GTEx	Liver	AMIGO1	0.28	0.13	lasso	7	0.15	6.9e-05	-4.380	-6.8	8.7e-12	0.16	0.27	0.09	TRUE
10	GTEx	Colon Transverse	STXBP3	0.26	0.09	enet	26	0.07	3.7e-04	0.783	-5.5	3.4e-08	0.18	0.93	0.01	TRUE
12	GTEx	Esophagus Mucosa	PSRC1	0.18	0.14	lasso	3	0.14	2.4e-09	-27.700	-27.9	3.8e-171	0.96	0.01	0.99	FALSE
17	GTEx	Liver	CELSR2	0.39	0.36	lasso	1	0.35	1.0e-10	-27.700	-27.7	4.2e-169	1.00	0.01	0.99	FALSE
20	GTEx	Muscle Skeletal	CELSR2	0.41	0.31	lasso	4	0.30	2.4e-30	-27.700	-27.5	4.7e-167	0.99	0.04	0.96	FALSE
59	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	PSRC1	0.16	0.20	lasso	3	0.19	3.7e-09	-27.400	-27.5	6.6e-166	0.95	0.01	0.99	FALSE
44	ROSMAP	Brain Pre-frontal Cortex	CELSR2	0.25	0.21	lasso	6	0.23	4.9e-29	-27.700	-27.3	3.3e-164	0.96	0.00	1.00	FALSE
57	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PSRC1	0.12	0.11	lasso	4	0.09	4.5e-06	-27.300	-26.8	1.1e-157	0.92	0.01	0.99	FALSE
47	YFS	Blood	PSRC1	0.25	0.18	enet	32	0.24	1.6e-76	-27.800	-23.9	4.3e-126	0.86	0.00	1.00	FALSE
53	The Cancer Genome Atlas	Colon Adenocarcinoma	PSRC1	0.07	0.06	lasso	1	0.04	1.8e-03	-23.900	-23.9	5.2e-126	0.75	0.01	0.83	FALSE
30	GTEx	Skin Sun Exposed Lower leg	CELSR2	0.18	0.05	lasso	6	0.06	8.1e-06	-23.900	-23.4	1.0e-120	0.75	0.01	0.97	FALSE
43	ROSMAP	Brain Pre-frontal Cortex	PSRC1	0.33	0.21	bslmm	430	0.26	1.2e-32	-27.700	-22.1	3.9e-108	0.82	0.00	1.00	FALSE
64	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	PSRC1	0.07	0.03	enet	8	0.05	3.4e-04	-27.800	-21.3	1.5e-100	0.77	0.01	0.92	FALSE
49	The Cancer Genome Atlas	Breast Invasive Carcinoma	PSRC1	0.03	0.00	blup	49	0.02	5.7e-05	-23.900	-21.0	1.2e-97	0.80	0.02	0.88	FALSE
69	The Cancer Genome Atlas	Stomach Adenocarcinoma	PSRC1	0.12	0.03	enet	6	0.08	1.5e-06	-28.000	-20.4	2.4e-92	0.76	0.00	0.99	FALSE
18	GTEx	Liver	ATXN7L2	0.39	0.04	lasso	12	0.21	1.3e-06	-7.110	-20.4	2.5e-92	0.70	0.07	0.80	FALSE
70	The Cancer Genome Atlas	Stomach Adenocarcinoma	SORT1	0.04	0.01	blup	60	0.03	4.4e-03	-27.900	-20.3	1.0e-91	0.64	0.01	0.79	FALSE
52	The Cancer Genome Atlas	Colon Adenocarcinoma	CELSR2	0.12	0.00	enet	21	0.04	3.0e-03	-27.900	-17.2	1.4e-66	0.58	0.00	0.76	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CELSR2	0.03	0.00	lasso	10	0.01	1.5e-02	-21.600	17.1	1.9e-65	-0.59	0.10	0.33	FALSE
58	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	MYBPHL	0.09	0.07	blup	46	0.06	5.7e-04	-2.930	-16.9	9.9e-64	0.55	0.04	0.39	FALSE
67	The Cancer Genome Atlas	Soft Tissue Sarcoma	PSRC1	0.09	0.00	blup	49	0.02	3.1e-02	-16.900	-16.7	7.4e-63	0.67	0.01	0.38	FALSE
2	CommonMind	Brain Pre-frontal Cortex	PSRC1	0.20	0.04	lasso	8	0.13	4.8e-16	5.200	-16.6	4.2e-62	0.63	0.02	0.98	FALSE
68	The Cancer Genome Atlas	Stomach Adenocarcinoma	CELSR2	0.08	0.00	blup	62	0.02	8.1e-03	-7.080	-16.1	2.9e-58	0.50	0.01	0.24	FALSE
56	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PSRC1	0.14	0.05	enet	6	0.08	7.5e-09	1.770	-14.4	3.8e-47	0.50	0.16	0.62	FALSE
8	GTEx	Cells Transformed fibroblasts	GPSM2	0.12	0.00	enet	24	0.01	5.6e-02	0.814	12.1	6.4e-34	-0.39	0.05	0.38	FALSE
16	GTEx	Liver	SYPL2	0.34	0.27	lasso	5	0.30	4.6e-09	-6.420	-11.9	1.8e-32	0.38	0.81	0.12	FALSE
28	GTEx	Pituitary	AC000032.2	0.36	-0.01	enet	1	0.05	1.8e-02	-10.900	-10.9	7.9e-28	0.46	0.05	0.12	FALSE
23	GTEx	Nerve Tibial	SYPL2	0.09	0.00	enet	27	0.05	1.9e-04	-13.000	9.9	4.4e-23	-0.34	0.09	0.25	FALSE
40	METSIM	Adipose	CELSR2	0.13	0.04	enet	28	0.06	5.0e-09	12.700	9.3	1.0e-20	-0.22	1.00	0.00	FALSE
65	The Cancer Genome Atlas	Prostate Adenocarcinoma	PSRC1	0.18	0.10	enet	11	0.10	1.6e-10	1.770	-8.6	6.7e-18	0.38	1.00	0.00	FALSE
26	GTEx	Pituitary	GPSM2	0.27	0.04	lasso	5	0.10	2.2e-03	-0.035	8.6	1.0e-17	-0.23	0.03	0.45	FALSE
74	The Cancer Genome Atlas	Thyroid Carcinoma	SYPL2	0.07	0.04	blup	45	0.03	4.9e-04	-6.280	8.5	1.4e-17	-0.26	0.57	0.27	FALSE
11	GTEx	Esophagus Mucosa	GPSM2	0.17	0.02	enet	34	0.07	1.5e-05	-0.912	-8.5	1.6e-17	0.22	0.50	0.09	FALSE
41	NTR	Blood	SORT1	0.05	0.06	lasso	6	0.06	2.1e-17	-7.210	-8.2	1.8e-16	0.20	1.00	0.00	FALSE
46	ROSMAP	Brain Pre-frontal Cortex	AMIGO1	0.08	0.03	blup	404	0.03	8.7e-05	-4.750	-8.1	3.9e-16	0.25	0.93	0.01	FALSE
31	GTEx	Skin Sun Exposed Lower leg	RP5-1160K1.3	0.08	0.02	lasso	3	0.04	3.7e-04	-13.000	7.9	2.2e-15	-0.27	0.15	0.15	FALSE
29	GTEx	Prostate	RP11-20O24.4	0.33	0.01	enet	30	0.13	3.2e-04	-7.790	-7.8	5.9e-15	0.37	0.04	0.32	FALSE
63	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	MYBPHL	0.16	0.18	enet	10	0.17	2.3e-11	-7.300	-7.5	9.5e-14	0.17	1.00	0.00	FALSE
4	GTEx	Brain Cerebellar Hemisphere	SYPL2	0.28	0.04	lasso	5	0.09	2.7e-03	-6.420	-7.4	1.0e-13	0.19	0.44	0.16	FALSE
37	GTEx	Thyroid	PSRC1	0.29	0.25	lasso	3	0.25	3.6e-19	1.770	-7.2	4.3e-13	0.33	1.00	0.00	FALSE
33	GTEx	Small Intestine Terminal Ileum	RP4-735C1.4	0.74	0.31	enet	47	0.43	6.9e-11	1.720	-7.1	1.4e-12	0.26	0.40	0.17	FALSE
35	GTEx	Testis	SYPL2	0.45	0.50	enet	22	0.54	5.0e-28	-6.720	7.0	1.9e-12	-0.18	1.00	0.00	FALSE
24	GTEx	Ovary	SYPL2	0.39	0.44	lasso	5	0.46	8.8e-13	-7.210	7.0	2.7e-12	-0.17	1.00	0.00	FALSE
22	GTEx	Muscle Skeletal	AMIGO1	0.16	0.09	lasso	9	0.08	5.7e-08	-4.350	-6.8	9.4e-12	0.18	1.00	0.00	FALSE
36	GTEx	Testis	ATXN7L2	0.28	0.34	lasso	4	0.33	3.7e-15	-6.570	6.7	1.7e-11	-0.17	1.00	0.00	FALSE
48	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	AMIGO1	0.10	0.14	enet	10	0.11	2.8e-09	-4.400	-6.7	2.6e-11	0.18	1.00	0.00	FALSE
21	GTEx	Muscle Skeletal	CYB561D1	0.07	0.00	lasso	3	0.00	7.2e-01	-7.080	6.6	3.4e-11	-0.18	0.31	0.02	FALSE
25	GTEx	Ovary	ATXN7L2	0.18	0.18	enet	17	0.13	5.6e-04	-6.490	6.6	3.5e-11	-0.16	0.46	0.04	FALSE
6	GTEx	Brain Cerebellum	SYPL2	0.16	0.02	enet	9	0.03	5.1e-02	-6.520	-6.6	4.2e-11	0.15	0.36	0.03	FALSE
55	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SYPL2	0.03	0.05	lasso	4	0.05	6.6e-06	-6.720	-6.5	6.6e-11	0.15	0.81	0.08	FALSE
27	GTEx	Pituitary	GSTM1	0.40	-0.01	enet	24	0.05	1.7e-02	-10.900	-6.4	1.3e-10	0.25	0.06	0.12	FALSE
72	The Cancer Genome Atlas	Thyroid Carcinoma	ATXN7L2	0.06	0.06	lasso	3	0.05	6.6e-06	-6.280	6.4	1.5e-10	-0.16	0.03	0.97	FALSE
34	GTEx	Stomach	SYPL2	0.23	0.18	lasso	8	0.21	2.3e-10	-6.420	-6.3	3.3e-10	0.10	1.00	0.00	FALSE
62	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	AMIGO1	0.13	0.13	blup	46	0.12	1.7e-13	-4.050	-6.2	4.9e-10	0.18	1.00	0.00	FALSE
32	GTEx	Small Intestine Terminal Ileum	GSTM3	0.78	0.30	enet	26	0.42	1.9e-10	1.850	-6.1	1.1e-09	0.19	0.57	0.12	FALSE
5	GTEx	Brain Cerebellar Hemisphere	ATXN7L2	0.24	-0.01	enet	9	-0.01	5.3e-01	-2.440	-6.0	1.6e-09	0.15	0.05	0.11	FALSE
38	GTEx	Uterus	SYPL2	0.29	0.13	lasso	7	0.04	5.1e-02	-6.500	6.0	2.7e-09	-0.16	0.13	0.05	FALSE
15	GTEx	Heart Left Ventricle	AMIGO1	0.27	0.10	enet	24	0.12	4.2e-07	-4.350	-5.9	2.8e-09	0.09	0.98	0.00	FALSE
7	GTEx	Breast Mammary Tissue (Male)	AMIGO1	0.21	0.10	lasso	2	0.12	8.4e-04	-4.380	-5.8	5.7e-09	0.17	0.08	0.06	FALSE
13	GTEx	Esophagus Mucosa	SORT1	0.20	0.07	lasso	6	0.04	6.7e-04	-2.720	-5.8	6.5e-09	0.29	0.19	0.20	FALSE
61	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	SYPL2	0.18	0.19	blup	45	0.18	4.7e-09	-6.570	-5.7	1.3e-08	0.10	0.99	0.01	FALSE
3	GTEx	Brain Caudate basal ganglia	AMIGO1	0.17	0.00	enet	10	0.00	4.4e-01	5.010	-5.6	2.6e-08	0.08	0.09	0.08	FALSE
71	The Cancer Genome Atlas	Testicular Germ Cell Tumors	AMIGO1	0.14	0.14	blup	46	0.14	1.1e-05	-4.350	-5.5	2.8e-08	0.14	0.38	0.39	FALSE
45	ROSMAP	Brain Pre-frontal Cortex	ATXN7L2	0.07	0.06	enet	12	0.09	5.6e-12	-6.520	5.4	7.9e-08	-0.17	1.00	0.00	FALSE
66	The Cancer Genome Atlas	Prostate Adenocarcinoma	SYPL2	0.08	0.08	blup	44	0.10	1.9e-10	-6.280	-5.3	1.0e-07	0.10	1.00	0.00	FALSE
50	The Cancer Genome Atlas	Breast Invasive Carcinoma	SYPL2	0.06	0.07	blup	45	0.08	8.5e-16	-6.500	-5.3	1.4e-07	0.14	1.00	0.00	FALSE
54	The Cancer Genome Atlas	Esophageal Carcinoma	AMIGO1	0.24	0.08	blup	46	0.18	3.0e-06	-4.460	-5.1	2.9e-07	0.14	0.09	0.30	FALSE
73	The Cancer Genome Atlas	Thyroid Carcinoma	PSRC1	0.11	0.08	enet	16	0.08	6.9e-08	1.770	-5.1	2.9e-07	0.24	0.99	0.00	FALSE