Hub : Genes

TMEM167B

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.072	0.0390	0.04400	0.089	0.002	0.087	0.08	0.088	5.4e-11	0.16	8.6e-11	6.1e-10	7.1e-11
2	GTEx	Adrenal Gland	0.214	0.0859	0.00850	-0.008	NA	-0.006	NA	-0.008	1.0e+00	NA	6.4e-01	NA	9.8e-01
3	GTEx	Colon Sigmoid	0.259	0.0930	0.00027	0.015	NA	0.009	NA	0.002	9.6e-02	NA	1.4e-01	NA	2.7e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.2	0.4	0.8	0.0	0.6	-0.9
Bipolar Disorder or Schizophrenia	0.1	0.3	0.8	0.0	0.9	0.1
Depressed Affect (Nagel 2018)	0.5	1.1	2.5	-0.8	-1.6	-0.4
Depression (Nagel 2018)	0.4	0.6	1.3	-1.1	-0.5	-0.5
Intelligence (Savage-Jansen 2018)	2.0	6.3	12.3	-1.4	2.1	-3.5
Neuroticism (Nagel 2018)	0.9	2.0	4.8	-2.2	0.1	-1.1
Schizophrenia (2018)	0.2	0.4	0.6	0.0	0.7	0.8
Schizophrenia vs Biploar Disorder	0.3	0.4	0.9	0.0	0.6	1.0
Worry (Nagel 2018)	0.8	1.8	3.7	-1.9	0.9	-0.9
Alzheimer’s Disease (in mother)	0.3	0.4	0.8	-0.6	-0.9	-0.2
Alzheimer’s Disease (in father)	0.6	0.6	1.1	-0.1	-1.1	-0.8
Alzheimer’s Disease (including proxy)	0.6	0.9	1.9	0.0	-1.4	-0.8
Crohns Disease (2017)	0.6	1.4	2.4	-0.0	-1.3	-1.5
Irritable Bowel Disease (IBD)	0.3	0.7	1.2	-0.7	-1.1	-0.7
Ulcerative Colitis (UC)	0.2	0.4	0.8	-0.9	-0.3	0.6
Major Depression (MDD)	1.4	1.7	2.6	-1.3	-1.0	-1.6
Reaction Time	0.3	0.6	1.1	0.8	-0.3	1.1
Verbal and Numeric Reasoning (VNR)	1.6	3.9	5.4	-1.7	1.9	-2.3
Breast Cancer	0.0	0.1	0.2	0.1	-0.2	0.5
Ovarian Cancer	0.9	1.2	2.6	0.6	-1.6	-0.8
Prostate Cancer	0.7	0.9	2.6	-1.6	-0.1	0.3
Age at First Birth	1.4	2.1	6.2	0.0	-0.3	-2.5
Bipolar Disorder (2011)	0.6	0.6	1.7	0.0	0.3	-1.3
Body Mass Index (BMI) (2010)	0.7	1.0	1.7	0.0	1.3	-1.2
Coronary Artery Disease (CAD)	1.5	1.8	4.3	0.0	-1.0	2.1
Crohns Disease (2012)	0.1	0.2	0.5	0.0	-0.5	-0.7
Mean Putamen Volume	0.2	0.2	0.4	0.3	0.2	0.6
Fasting Glucose	2.8	3.4	6.6	-0.9	-2.6	-1.7
HbA1C	0.7	0.8	1.7	1.3	0.6	-0.6
HDL Cholesterol	2.1	3.5	10.2	0.0	3.2	-0.4
LDL Cholesterol	15.6	24.6	73.3	0.0	-0.8	8.6
Lupus	0.6	1.0	2.4	-0.0	-1.6	-0.7
Neuroticism (2016)	0.3	0.4	0.6	-0.7	0.5	0.8
Primary Biliary Cirrhosis	0.3	0.5	0.8	-0.0	0.8	0.9
Rheumatoid Arthritis	0.1	0.1	0.3	0.0	0.5	0.3
Schizophrenia (2014)	0.1	0.2	0.3	0.0	0.6	0.6
Triglycerides	0.8	1.2	3.2	0.0	-1.8	0.7
Type 2 Diabetes (T2D) (2012)	0.4	0.4	1.3	0.0	1.1	-0.0
Ulcerative Colitis	0.5	0.7	1.9	0.0	0.3	1.4
Blood Eosinophil Count	0.1	1.1	2.8	0.7	-0.3	-1.7
Blood Platelet Count	0.2	2.3	2.8	-1.7	-1.2	1.6
Blood Red Count	0.7	6.9	12.9	1.3	-2.5	-3.6
Blood White Count	0.9	6.8	14.7	1.4	-3.8	-2.0
Heel T-Score	0.5	4.3	5.8	2.2	-1.6	-2.4
BMI	0.2	1.4	3.9	0.7	-0.0	-2.0
Height	0.1	2.3	5.5	0.4	-1.1	-2.3
Waist Hip Ratio (WHR)	0.6	2.8	7.6	0.7	0.7	-2.8
Systolic Blood Pressure	0.1	0.4	0.7	0.2	-0.6	-0.9
Smoking Status	0.2	0.6	1.1	-0.8	0.2	-1.0
Allergy or Eczema	0.4	1.2	3.1	0.6	0.3	-1.8
Cardiovascular Disease	0.7	2.4	4.3	-1.5	-0.7	2.1
Hypothyroidism (self reported)	0.2	0.4	0.9	-0.3	-0.5	-1.0
Respiratory disease	1.0	2.2	6.0	0.8	0.3	-2.5
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.2	0.5	-1.1	-0.3
Lung FEV1/FVC ratio	0.3	1.4	3.5	0.8	-1.9	-0.1
Lung FVC	0.1	0.4	1.1	0.4	-1.0	-0.3
Neuroticism	0.6	1.5	3.3	-1.8	0.3	-1.1
Chronotype (morning person)	0.1	0.2	0.5	-0.7	0.2	-0.4
Hair Pigment	0.0	0.9	1.6	-0.1	-1.1	1.3
Tanning	0.2	2.4	6.2	-0.0	1.0	-2.5
Hand grip strength (left)	0.1	0.3	0.6	-0.2	0.8	0.7
Number of treatments/medications taken	1.5	2.6	6.1	-1.4	0.1	2.5
Average weekly spirits intake	2.5	3.1	4.5	2.1	-0.8	-2.0
Sensitivity / hurt feelings	0.5	0.9	2.3	-1.5	0.7	0.1
Frequency of depressed mood in last 2 weeks	1.7	2.4	6.0	-2.5	1.1	0.1
Hearing difficulty/problems: Yes	0.5	0.7	1.1	1.1	0.4	-0.9
Relative age of first facial hair	0.1	0.2	0.4	-0.6	-0.3	0.1
Other serious medical condition/disability diagnosed by doctor	1.2	1.5	2.3	-1.1	1.0	1.5
Ever used hormone-replacement therapy (HRT)	1.6	2.0	2.7	1.6	-1.6	-0.8
Ever had hysterectomy (womb removed)	2.4	2.7	4.5	1.7	2.1	0.9
Systolic blood pressure, automated reading	0.2	0.7	1.9	-0.1	0.4	-1.4
Eye problems/disorders: Diabetes related eye disease	1.7	1.9	4.1	2.0	-0.5	-1.2
Angina	0.7	0.9	2.4	-0.4	0.4	1.5
Medication for hormone replacement therapy	0.1	0.1	0.2	0.3	-0.1	-0.4
Vitamin and mineral supplements	0.3	0.4	1.0	0.0	-0.6	1.0
Supplements: Zinc	1.0	1.1	2.7	-1.6	0.6	0.5
Medication: Co-codamol	1.8	2.0	3.9	-2.0	1.0	1.1
Medication: Metformin	1.0	1.4	2.1	1.4	-0.2	1.5
Diabetes (father)	0.3	0.4	0.8	0.4	0.6	-0.9
Diabetes (mother)	0.4	0.6	0.7	-0.6	-0.7	0.9
Severe depression (siblings)	1.3	1.5	2.9	-1.7	-0.9	0.9
Pack years adult smoking proportion	1.7	2.6	7.2	0.4	-0.6	2.7
Impedance of leg (right)	1.5	7.1	19.5	-1.2	-0.5	4.4
Leg fat-free mass (left)	0.4	2.4	6.1	1.0	0.1	-2.5
Trunk fat percentage	0.3	1.3	2.7	0.1	1.1	1.7
Hand grip strength (right)	0.0	0.1	0.4	0.6	0.1	0.1
Townsend deprivation index at recruitment	0.8	1.1	3.0	0.2	-1.7	-0.5
Current tobacco smoking	0.1	0.2	0.4	0.6	-0.4	0.5
Average weekly fortified wine intake	0.3	0.3	0.6	0.2	0.8	-0.5
Maternal smoking around birth	1.1	1.5	2.5	0.8	1.2	1.6
Fed-up feelings	0.5	0.9	2.4	-0.3	-1.6	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.0	-1.0	0.1	0.5
Relative age voice broke	0.2	0.4	1.0	1.0	0.1	-0.4
Taking other prescription medications	0.2	0.3	0.7	0.0	0.6	0.8
Age when periods started (menarche)	0.1	0.3	0.6	-0.5	0.1	0.8
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	3.1	0.6	1.8	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.1	5.1	2.2	-1.1	-0.0
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	2.5	-0.2	-0.2	1.6
Qualifications: CSEs or equivalent	1.9	2.6	4.3	1.6	-2.1	0.9
Serious illness, injury or assault to yourself	1.7	2.1	4.5	1.3	0.3	2.1
High blood pressure	0.4	1.2	2.2	-1.1	-0.2	-1.5
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.1	-0.5	0.6	-1.0
Multivitamins +/- minerals	1.1	1.4	2.9	-0.3	1.0	-1.7
Stomach or abdominal pain in last month	1.9	2.3	5.1	-1.1	0.8	2.3
Supplements: Glucosamine	0.8	1.0	1.9	-0.7	1.4	-0.9
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	0.9	-0.9	0.2	0.0
Medication: Atenolol	0.3	0.4	1.2	-0.2	1.1	0.0
Medication: Levothyroxine sodium	0.1	0.2	0.4	0.2	-0.5	-0.6
Sitting height	0.4	2.8	6.2	0.9	-2.5	-1.2
Chronic bronchitis/emphysema (father)	0.4	0.5	1.1	-1.1	0.2	-0.6
High blood pressure (mother)	0.4	0.5	1.0	1.0	-0.7	0.4
Body mass index (BMI)	0.1	0.6	0.9	0.4	1.0	-0.8
Impedance of leg (left)	1.6	7.7	21.2	-1.1	-0.9	4.6
Leg predicted mass (left)	0.4	2.3	6.0	0.9	0.1	-2.5
Trunk fat mass	0.1	0.4	1.0	0.3	1.0	0.5
Waist circumference	0.2	0.9	1.8	0.2	0.9	-1.3
Number of incorrect matches in round	0.4	0.7	1.0	-0.7	-1.0	-0.9
Past tobacco smoking	0.8	1.5	2.5	1.4	-0.1	1.6
Alcohol usually taken with meals	0.3	0.5	0.8	0.6	0.9	0.7
Nervous feelings	0.9	1.8	2.6	-1.6	1.3	-1.0
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.5	2.7	-1.6	1.4	0.2
Hearing difficulty/problems with background noise	1.9	3.1	8.9	3.0	0.4	-0.4
Hair/balding pattern: Pattern 2	0.6	0.7	2.0	-0.3	-0.0	-1.4
Had menopause	0.9	1.2	2.3	-1.5	0.1	-1.1
Had other major operations	0.7	0.8	2.5	-0.2	-1.6	0.0
Forced vital capacity (FVC)	0.2	0.9	2.6	0.3	-1.6	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.0	5.6	2.4	-0.5	0.5
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	2.5	-0.1	0.1	1.6
Qualifications: None of the above	1.0	2.2	5.9	0.7	0.4	2.4
Financial difficulties in last 2 years	0.8	1.0	2.0	1.0	-0.3	-1.4
Mouth/teeth dental problems	0.2	0.3	0.5	0.7	-0.7	0.3
Heart attack	0.6	0.8	1.0	0.9	-0.7	1.0
Allergy	0.2	0.5	0.7	-0.8	-0.5	0.8
Pain all over the body in last month	0.1	0.2	0.3	-0.4	-0.2	0.5
Diabetes (self-reported)	0.2	0.3	0.5	0.5	-0.7	0.4
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	1.1	-1.1	1.0	-0.5
Medication: Ramipril	0.4	0.5	0.6	-0.6	-0.7	-0.8
Medication: Simvastatin	2.2	3.2	5.4	-0.3	-2.1	2.3
Fluid intelligence score	1.2	2.5	4.9	-0.6	1.5	-2.2
Illnesses of siblings	0.6	0.8	1.2	-1.1	-0.4	-1.1
Neuroticism score	0.3	0.7	2.0	-1.4	0.3	-0.1
Weight	0.1	0.6	1.6	0.2	0.2	-1.3
Impedance of arm (right)	1.3	5.9	17.1	-0.7	-0.3	4.1
Arm fat percentage (right)	0.3	1.1	2.1	-0.4	1.4	1.0
Trunk fat-free mass	0.8	4.4	12.3	0.5	-0.8	-3.5
Hip circumference	0.0	0.1	0.1	0.4	0.0	0.3
Time employed in main current job	0.8	0.9	2.4	1.5	0.1	0.6
Alcohol intake versus 10 years previously	0.9	1.3	2.8	1.7	-0.8	-0.6
Father’s age at death	1.9	2.6	5.2	-1.5	0.6	-2.3
Worrier / anxious feelings	1.3	2.5	5.2	-1.4	2.3	0.3
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	0.7	-0.6	0.9	0.0
Falls in the last year	1.6	2.1	5.7	0.8	-0.0	2.4
Hair/balding pattern: Pattern 3	1.1	1.6	2.6	1.6	-1.3	-0.7
Number of live births	1.3	1.8	2.9	1.7	0.8	1.4
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	1.7	0.2	-1.3	0.1
Pulse rate	0.2	0.4	0.7	0.6	-0.9	-0.2
Happiness	0.9	1.1	1.7	-1.1	1.3	0.5
Noisy workplace	1.6	2.0	3.0	-0.1	1.7	1.7
Qualifications: A levels/AS levels or equivalent	1.9	4.1	8.9	-3.0	1.2	-1.4
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.4	0.6	-0.5	-0.0
Mouth/teeth dental problems: Dentures	0.6	0.9	1.3	1.1	0.7	-1.0
Asthma	0.2	0.5	0.8	0.9	0.2	-0.7
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	2.2	0.7	0.1	1.5
Medication: Cholesterol lowering	2.4	3.7	7.1	-1.2	-1.6	2.7
Depression (self-reported)	1.5	1.8	5.1	-2.3	0.2	0.3
Medication: Lansoprazole	1.4	1.6	3.5	0.1	1.1	1.9
Prospective memory result	0.4	0.5	0.7	-0.6	0.8	-0.6
Lung cancer (father)	0.0	0.0	0.1	0.3	0.2	-0.0
Illnesses of mother	0.7	0.9	1.1	-1.1	0.6	1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	3.0	0.2	-1.7	-0.2
Pulse wave Arterial Stiffness index	0.2	0.2	0.4	-0.4	0.4	0.6
Impedance of arm (left)	1.0	4.4	11.8	-1.1	-0.5	3.4
Arm fat mass (right)	0.1	0.5	1.2	-0.5	1.1	-0.3
Trunk predicted mass	0.8	4.5	12.8	0.4	-0.8	-3.6
Standing height	0.1	1.2	2.4	-0.3	-1.6	-1.1
Length of working week for main job	0.5	0.5	1.0	-1.0	0.4	-0.6
Exposure to tobacco smoke at home	0.6	0.7	1.6	-0.6	0.4	1.3
Breastfed as a baby	0.4	0.5	1.1	-0.6	0.2	-1.1
Tense / ‘highly strung’	1.3	2.2	6.4	-2.5	0.4	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	1.0	2.3	-1.5	0.0	0.8
Hair/balding pattern: Pattern 4	1.3	3.1	4.9	-0.1	2.1	2.2
Birth weight of first child	0.9	1.6	2.4	-1.2	1.6	-1.0
Peak expiratory flow (PEF)	0.1	0.3	0.9	0.1	-0.9	0.3
Pulse wave reflection index	0.6	0.8	0.9	-0.9	0.8	0.9
Ever highly irritable/argumentative for 2 days	1.5	1.8	4.6	-0.8	2.1	-0.4
Loud music exposure frequency	1.0	1.1	3.0	0.5	-1.7	-0.1
Qualifications: O levels/GCSEs or equivalent	1.9	3.0	4.2	-2.0	1.5	-1.6
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.6	0.8	0.2	-0.0
Blood clot in the leg (DVT)	0.1	0.2	0.5	0.2	-0.1	0.7
Medication: Paracetamol	0.3	0.5	0.8	-0.9	-0.5	0.6
Headache pain in last month	0.6	1.1	1.8	-0.2	-1.2	1.4
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	1.5	0.6	1.1	-1.2
Glaucoma (self-reported)	1.2	1.4	3.2	1.8	-0.8	-0.4
Gout (self-reported)	0.1	0.2	0.5	-0.1	-0.4	-0.7
Hypothyroidism/myxoedema (self-reported)	0.0	0.1	0.2	-0.1	-0.1	-0.4
Medication: Amlodipine	0.1	0.1	0.4	0.6	-0.0	0.2
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.9	-0.0	1.0	-0.4
Birth weight	0.2	0.5	0.9	1.0	0.6	-0.5
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.1	0.6	1.1	0.7
High blood pressure (siblings)	0.4	0.6	1.3	0.5	-0.4	1.1
Forced vital capacity (FVC), Best measure	0.3	1.3	3.0	0.2	-1.7	-0.9
Body fat percentage	0.4	1.7	3.1	-0.1	1.4	1.8
Leg fat percentage (right)	0.3	1.0	1.7	0.2	1.1	1.3
Arm fat-free mass (right)	0.5	2.5	7.4	0.1	-0.1	-2.7
Exposure to tobacco smoke outside home	0.3	0.4	0.9	-0.3	-0.5	1.0
Comparative body size at age 10	0.1	0.2	0.4	-0.1	0.6	-0.4
Number of full brothers	1.6	2.0	5.5	0.8	0.1	2.3
Worry too long after embarrassment	0.4	0.6	1.0	-0.9	1.0	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.4	1.8	3.2	-1.8	1.5	0.4
Wheeze or whistling in the chest in last year	0.6	1.0	2.5	1.6	0.4	-0.7
Number of children fathered	0.8	0.9	1.4	0.9	1.2	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.8	5.1	-0.0	0.5	-2.2
Age at first live birth	0.6	1.0	1.8	-0.8	-0.7	-1.3
Pulse wave peak to peak time	0.4	0.5	0.6	0.5	-0.8	-0.8
Health satisfaction	2.1	2.8	4.9	-1.1	2.2	1.5
Shortness of breath walking on level ground	1.2	1.4	2.4	-1.1	1.6	0.8
Qualifications: College or University degree	1.0	3.1	9.3	-0.2	0.0	-3.0
Eye problems/disorders: None of the above	0.4	0.5	0.9	-0.7	0.2	-0.9
Mouth/teeth dental problems: Loose teeth	0.3	0.4	0.6	0.7	-0.8	-0.2
Emphysema/chronic bronchitis	0.3	0.3	0.6	0.8	0.6	0.3
Medication for pain relief, constipation, heartburn	1.3	2.2	6.2	0.3	0.6	-2.5
Neck or shoulder pain in last month	3.3	4.7	11.8	1.4	0.6	3.4
Medication: Blood pressure	0.3	0.6	0.6	-0.7	-0.8	-0.8
Angina (self-reported)	0.8	1.1	2.7	-0.0	0.7	1.6
Migraine (self-reported)	0.0	0.0	0.0	0.1	-0.2	0.2
Medication: Ibuprofen	0.7	0.8	2.0	0.4	0.6	1.4
Medication: Allopurinol	0.1	0.1	0.3	0.0	-0.3	-0.6
Medication: Omeprazole	1.7	2.0	3.1	-1.2	1.8	1.3
Medication: Seretide 50 evohaler	0.3	0.4	0.8	-0.9	-0.2	-0.4
Mean time to correctly identify matches	0.1	0.2	0.5	0.7	-0.2	0.0
Heart disease (mother)	0.1	0.1	0.1	0.3	-0.1	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	0.8	-0.6	0.8	0.9
Whole body fat mass	0.2	0.8	1.9	0.1	1.4	0.6
Leg fat mass (right)	0.1	0.5	1.2	0.4	1.1	0.4
Arm predicted mass (right)	0.5	2.8	8.2	0.3	-0.2	-2.9
Pulse rate, automated reading	0.9	3.1	4.0	1.3	-2.0	1.9
Alcohol intake frequency.	0.5	1.1	2.1	1.5	-0.9	-0.6
Comparative height size at age 10	0.2	1.0	2.7	-1.6	-0.5	0.1
Number of full sisters	0.9	1.1	2.2	1.5	-0.8	0.6
Suffer from ‘nerves’	1.7	2.6	6.8	-2.6	0.4	0.9
Overall health rating	0.3	0.5	0.9	0.6	1.0	0.6
Chest pain or discomfort	1.7	2.5	7.3	0.3	-0.2	2.7
Had major operations	1.3	1.5	2.7	1.6	-0.4	1.3
Age at last live birth	0.8	1.2	2.7	0.4	-1.6	-0.9
Family relationship satisfaction	0.7	0.8	2.3	-1.5	0.5	-0.0
Leg pain on walking	1.3	1.6	2.3	-1.5	-0.9	1.3
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	3.0	-0.2	-0.6	1.7
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.1	1.1	-0.7	0.3
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	2.0	-1.4	0.5	0.9
Medication: Aspirin	1.4	1.8	4.0	-1.0	-0.6	2.0
Supplements: Vitamin C	1.5	1.8	4.3	-2.1	-0.7	-0.9
Knee pain experienced in last month	0.3	0.4	0.9	0.3	0.4	1.0
Hypertension (Self-reported)	0.3	0.9	1.4	-1.1	-0.1	-1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.5	0.9	0.1	1.0	0.8
Illnesses of father: Heart disease	1.7	2.3	5.8	2.4	-1.0	0.4
Illnesses of siblings: Diabetes	1.1	1.4	3.6	-1.9	-0.7	0.2
Smoking status: Previous	1.5	2.2	4.6	-2.1	0.2	-1.4
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	2.2	0.5	-1.5	0.7
Whole body fat-free mass	0.6	3.5	10.1	0.7	-0.3	-3.2
Leg fat-free mass (right)	0.5	2.6	6.9	0.8	-0.1	-2.6
Arm fat percentage (left)	0.2	1.0	2.3	-0.3	1.5	0.7
Average weekly red wine intake	0.5	0.7	1.7	-0.1	1.3	0.6
Handedness (chirality/laterality): Left-handed	1.5	1.8	2.9	-1.2	1.7	1.0
Mood swings	1.2	2.2	3.8	-0.9	-1.9	-1.4
Loneliness, isolation	1.8	2.4	5.5	-0.9	-2.3	1.0
Long-standing illness, disability or infirmity	1.1	1.6	3.3	0.6	1.1	1.8
Ever had bowel cancer screening	0.1	0.2	0.3	0.4	-0.5	-0.3
Diabetes diagnosed by doctor	0.4	0.6	1.0	1.0	-0.7	0.6
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	3.8	-0.4	-2.0	-0.5
Friendships satisfaction	0.6	0.7	1.5	-0.7	1.2	0.2
Qualifications: nursing, teaching	0.1	0.1	0.2	0.4	0.4	0.1
Commuting to job workplace: Walk	0.3	0.3	0.5	0.5	0.5	-0.7
Eye problems/disorders: Cataract	0.2	0.2	0.4	0.1	0.3	0.7
Mouth/teeth dental problems: Mouth ulcers	0.7	1.0	1.9	-0.9	-0.7	1.4
Medication for cholesterol	0.9	1.4	4.3	-0.0	0.0	-2.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.9	1.8	-0.1	-0.9	-1.3
Back pain experienced in last month	0.5	0.8	1.6	-0.8	-0.3	1.2
Mineral and other dietary supplements	1.9	2.5	5.7	2.4	-1.0	0.9
Breast cancer (self-reported)	3.7	4.4	6.8	-2.1	2.6	1.4
Asthma (self-reported)	0.3	0.7	1.1	1.0	0.4	-0.9
Osteoporosis (self-reported)	1.0	1.2	2.1	-1.4	0.6	1.0
Osteoarthritis (self-reported)	1.6	2.1	4.6	-0.5	2.1	1.2
Medication: Aspirin	1.1	1.4	3.3	-0.9	-0.5	1.8
Medication: Gliclazide	1.7	2.0	4.9	0.0	-1.0	2.2
Illnesses of father: None of the above (group 1)	0.4	0.5	1.0	1.0	0.2	0.8
Smoking status: Current	0.2	0.3	0.6	0.8	0.0	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	1.8	0.7	-1.3	-0.7
Whole body water mass	0.6	3.6	10.4	0.5	-0.2	-3.2
Leg predicted mass (right)	0.5	2.4	6.5	0.9	-0.1	-2.5
Arm fat mass (left)	0.1	0.4	1.1	-0.3	1.1	-0.3
Number of self-reported non-cancer illnesses	0.1	0.2	0.5	-0.1	-0.7	0.1
Average weekly champagne plus white wine intake	0.5	0.6	1.4	1.2	0.6	-0.5
Miserableness	1.1	1.9	5.3	-0.4	0.5	2.3
Guilty feelings	0.9	1.3	3.3	-1.8	0.8	0.2
Wears glasses or contact lenses	0.6	0.7	1.7	-1.3	0.4	-0.5
Ever taken oral contraceptive pill	0.3	0.4	0.6	-0.8	0.5	0.5
Hearing aid user	0.6	0.7	1.3	-0.1	0.8	1.1
Mother’s age at death	1.3	1.6	2.9	-1.7	0.3	-1.4
Financial situation satisfaction	0.6	0.8	2.2	-0.2	0.2	1.5
Tinnitus: Yes, now most or all of the time	1.0	1.2	3.0	1.7	0.5	0.5
Commuting to job workplace: Public transport	0.5	0.5	1.1	-1.1	0.3	-0.7
Eye problems/disorders: Glaucoma	0.3	0.4	0.6	0.6	-0.7	0.4
Medication: Blood pressure	0.1	0.2	0.5	0.4	-0.7	0.1
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.0	-0.4	0.8	1.0
Supplements: Fish oil (including cod liver oil)	2.1	2.7	4.0	-1.9	0.7	-2.0
High cholesterol (Self-reported)	3.7	6.6	13.3	0.3	-2.5	3.6
Medication: Bendroflumethiazide	0.3	0.4	0.7	-0.8	0.5	-0.5
Medication: Paracetamol	0.9	1.3	3.5	-1.9	-0.6	0.4
Medication: Lisinopril	0.5	0.6	1.8	1.3	-0.1	-0.2
Medication: Atorvastatin	3.2	3.9	10.4	-0.9	-0.6	3.2
Illnesses of father: High blood pressure	3.6	4.5	7.1	-1.9	-2.7	-1.6
Alcohol drinker status: Never	0.8	0.9	2.1	1.5	-0.7	0.3
Ever smoked	2.0	3.5	8.9	-0.6	-1.2	-3.0
Basal metabolic rate	0.5	2.5	7.2	0.5	-0.2	-2.7
Leg fat percentage (left)	0.2	0.7	1.5	0.2	0.7	1.2
Arm fat-free mass (left)	0.5	2.4	7.1	0.2	-0.2	-2.7
Number of operations (self-reported)	1.1	1.7	4.6	2.1	-0.4	0.5
Average weekly beer plus cider intake	0.9	1.2	1.7	1.3	0.5	1.3
Irritability	0.4	0.6	1.5	-1.2	0.2	-0.5
Risk taking	0.7	1.0	1.3	0.8	1.1	-1.2
Ever had prostate specific antigen (PSA) test	0.5	0.6	0.8	0.2	-0.9	-0.9
Fractured/broken bones in last 5 years	0.1	0.1	0.1	-0.4	-0.1	0.3
Age started oral contraceptive pill	0.3	0.4	0.5	0.6	0.5	-0.7
Diastolic blood pressure, automated reading	0.2	0.5	0.9	-0.9	0.8	-0.2
Ever depressed for a whole week	0.2	0.3	0.5	0.0	0.6	0.7
Unable to work because of sickness or disability	0.4	0.5	1.5	0.1	1.2	-0.1
Commuting to job workplace: Cycle	0.8	1.0	1.3	0.5	-1.1	-1.1
Myopia	1.0	1.4	3.9	0.5	-0.4	-2.0
Vascular/heart problems diagnosed by doctor	0.3	0.9	1.6	1.3	0.2	1.0
Cholesterol lowering medication	4.2	6.3	16.6	0.4	-1.4	4.1
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	2.0	-0.7	1.4	0.8
Pain experienced in last month	1.5	2.5	6.9	-0.0	-0.8	-2.6
Supplements: Calcium	0.2	0.3	0.5	-0.7	-0.4	0.4
Basal cell carcinoma (self-reported)	1.6	1.9	5.5	-0.4	-2.4	-0.3
Heart attack/myocardial infarction (self-reported)	0.6	0.8	1.4	0.9	-0.5	1.2
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.0	0.1	-0.1	1.0
Heart disease (siblings)	1.9	2.3	3.8	2.0	0.3	1.7
Alcohol drinker status: Previous	0.4	0.4	1.0	1.0	-0.4	-0.4
Pack years of smoking	1.4	2.1	5.4	0.2	-0.9	2.3
Impedance of whole body	1.3	6.6	18.1	-1.2	-0.5	4.3
Leg fat mass (left)	0.1	0.4	1.0	0.3	1.0	0.4
Arm predicted mass (left)	0.4	2.1	6.2	0.3	-0.4	-2.5