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chr12:120,044,549-125,196,704

Best TWAS P=2.02e-68 · Best GWAS P=8.39e-70 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
26	GTEx	Esophagus Muscularis	UNC119B	0.11	0.11	lasso	3	0.07	4.7e-05	17.4	17.5	2.0e-68	0.94	0.00	1.00	TRUE
1	CommonMind	Brain Pre-frontal Cortex	ACADS	0.05	0.06	lasso	2	0.05	3.0e-07	17.7	17.1	1.2e-65	0.99	0.00	1.00	TRUE
25	GTEx	Esophagus Muscularis	ACADS	0.11	0.04	enet	8	0.04	1.7e-03	17.4	16.3	6.4e-60	0.90	0.00	0.99	TRUE
44	GTEx	Skin Sun Exposed Lower leg	MLEC	0.12	0.10	lasso	4	0.12	5.4e-10	17.4	-15.3	1.3e-52	-0.82	0.00	1.00	TRUE
79	The Cancer Genome Atlas	Prostate Adenocarcinoma	MLEC	0.05	0.05	lasso	3	0.04	1.7e-05	13.7	14.1	3.4e-45	0.78	0.13	0.55	TRUE
23	GTEx	Esophagus Gastroesophageal Junction	UNC119B	0.16	0.01	lasso	6	0.00	2.3e-01	4.7	9.9	4.4e-23	0.63	0.03	0.78	TRUE
22	GTEx	Colon Transverse	MLXIP	0.20	0.18	enet	23	0.14	5.8e-07	-6.6	-7.2	6.3e-13	0.05	0.03	0.97	TRUE
85	The Cancer Genome Atlas	Stomach Adenocarcinoma	MLXIP	0.06	0.02	blup	68	0.04	1.2e-03	-6.6	-7.2	6.4e-13	0.08	0.03	0.79	TRUE
3	GTEx	Adipose Subcutaneous	RP11-380L11.3	0.09	0.03	lasso	3	0.03	1.4e-03	-6.3	-6.9	4.1e-12	0.00	0.02	0.97	TRUE
83	The Cancer Genome Atlas	Rectum Adenocarcinoma	MLXIP	0.18	0.14	lasso	4	0.13	5.1e-04	-6.7	-6.9	5.0e-12	0.06	0.02	0.91	TRUE
42	GTEx	Ovary	MLEC	0.42	-0.01	enet	42	0.10	2.2e-03	4.9	6.7	2.2e-11	0.11	0.06	0.10	TRUE
63	The Cancer Genome Atlas	Colon Adenocarcinoma	MLXIP	0.06	0.04	lasso	7	0.02	2.7e-02	-6.7	-6.7	2.5e-11	0.12	0.03	0.91	TRUE
13	GTEx	Brain Putamen basal ganglia	WDR66	0.25	0.01	enet	16	-0.01	5.6e-01	-4.5	6.4	1.6e-10	-0.08	0.06	0.22	TRUE
56	YFS	Blood	SIRT4	0.18	0.12	enet	35	0.13	2.6e-41	2.5	6.0	1.9e-09	0.20	1.00	0.00	TRUE
74	The Cancer Genome Atlas	Brain Lower Grade Glioma	WDR66	0.14	0.16	lasso	5	0.20	1.2e-21	-6.1	5.8	5.5e-09	0.02	0.11	0.89	TRUE
43	GTEx	Skin Not Sun Exposed Suprapubic	ABCB9	0.13	0.15	lasso	11	0.11	2.1e-06	-5.2	-5.7	9.6e-09	0.08	0.02	0.98	TRUE
81	The Cancer Genome Atlas	Prostate Adenocarcinoma	RNF10	0.04	0.01	lasso	6	0.02	5.9e-03	-2.2	5.7	1.4e-08	0.20	0.05	0.17	TRUE
69	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	WDR66	0.15	0.22	enet	13	0.21	2.4e-23	-5.5	5.5	3.8e-08	0.03	0.77	0.23	TRUE
73	The Cancer Genome Atlas	Brain Lower Grade Glioma	TMEM120B	0.05	0.00	blup	44	0.02	1.1e-03	2.4	5.3	9.6e-08	-0.01	0.00	0.07	TRUE
76	The Cancer Genome Atlas	Lung Adenocarcinoma	SPPL3	0.06	0.02	enet	17	0.03	2.8e-04	-3.2	-5.3	1.1e-07	-0.40	0.28	0.40	TRUE
59	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	LRRC43	0.06	0.03	enet	6	0.03	8.7e-04	4.3	5.2	1.5e-07	-0.13	0.13	0.23	TRUE
33	GTEx	Heart Left Ventricle	RHOF	0.10	0.05	lasso	3	0.08	6.4e-05	-4.4	-5.2	2.4e-07	0.06	0.40	0.03	TRUE
40	GTEx	Nerve Tibial	ACADS	0.14	0.10	enet	18	0.08	1.7e-06	13.7	16.5	6.3e-61	0.83	0.06	0.94	FALSE
8	GTEx	Artery Tibial	ACADS	0.09	0.01	lasso	6	0.04	3.6e-04	13.7	16.0	2.5e-57	0.79	0.01	0.99	FALSE
10	GTEx	Brain Cerebellum	ACADS	0.45	0.28	enet	36	0.28	8.8e-09	17.4	15.9	1.3e-56	0.77	0.00	1.00	FALSE
58	YFS	Blood	UNC119B	0.04	0.03	enet	9	0.03	9.2e-10	13.7	-15.4	3.0e-53	-0.82	0.02	0.98	FALSE
54	YFS	Blood	ACADS	0.05	0.03	bslmm	421	0.03	3.1e-10	17.7	-15.0	1.4e-50	-0.86	0.00	1.00	FALSE
82	The Cancer Genome Atlas	Prostate Adenocarcinoma	UNC119B	0.04	0.02	lasso	3	0.02	6.1e-03	12.1	13.3	1.9e-40	0.72	0.05	0.15	FALSE
55	YFS	Blood	MLEC	0.07	0.01	bslmm	405	0.05	1.5e-15	-11.0	-12.5	7.7e-36	-0.55	0.93	0.07	FALSE
46	GTEx	Skin Sun Exposed Lower leg	CABP1	0.13	0.00	enet	36	0.06	1.1e-05	13.7	-12.4	2.0e-35	-0.57	0.01	0.93	FALSE
11	GTEx	Brain Cortex	ACADS	0.40	0.10	enet	26	0.30	6.3e-09	17.4	12.3	1.4e-34	0.68	0.00	0.99	FALSE
41	GTEx	Nerve Tibial	UNC119B	0.09	0.08	lasso	3	0.06	8.7e-05	10.5	11.4	5.9e-30	0.72	0.25	0.68	FALSE
27	GTEx	Esophagus Muscularis	RP11-173P15.5	0.18	0.02	enet	24	0.07	6.7e-05	17.4	11.2	2.6e-29	0.63	0.00	0.99	FALSE
48	GTEx	Testis	ACADS	0.17	0.13	lasso	3	0.10	3.5e-05	10.5	10.4	1.5e-25	0.69	0.73	0.14	FALSE
36	GTEx	Muscle Skeletal	ACADS	0.09	0.02	lasso	5	0.02	2.4e-03	10.4	-10.4	2.8e-25	-0.72	0.04	0.92	FALSE
16	GTEx	Cells EBV-transformed lymphocytes	POP5	0.33	0.01	enet	27	0.08	1.4e-03	-1.5	-10.2	2.5e-24	-0.25	0.07	0.19	FALSE
75	The Cancer Genome Atlas	Lung Adenocarcinoma	CABP1	0.06	0.03	blup	54	0.02	6.8e-04	-11.0	-9.5	2.7e-21	-0.52	0.06	0.19	FALSE
6	GTEx	Artery Aorta	SPPL3	0.18	0.15	enet	13	0.17	1.4e-09	-3.2	-8.0	1.1e-15	-0.60	0.85	0.14	FALSE
17	GTEx	Cells Transformed fibroblasts	SPPL3	0.13	0.14	lasso	5	0.14	1.2e-10	-8.1	-7.7	1.3e-14	-0.56	1.00	0.00	FALSE
57	YFS	Blood	SPPL3	0.02	0.00	blup	460	0.01	2.1e-03	16.2	-7.6	2.3e-14	-0.55	0.04	0.79	FALSE
2	CommonMind	Brain Pre-frontal Cortex	DYNLL1	0.06	0.01	blup	413	0.05	2.1e-06	-2.4	7.6	3.3e-14	0.45	0.23	0.39	FALSE
78	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	MLEC	0.26	0.08	lasso	1	0.09	2.6e-04	7.1	7.1	1.2e-12	0.23	0.16	0.04	FALSE
51	METSIM	Adipose	CCDC92	0.10	0.01	bslmm	435	0.06	5.5e-10	1.8	-6.9	5.7e-12	-0.02	0.13	0.87	FALSE
20	GTEx	Colon Sigmoid	SPPL3	0.13	0.03	lasso	3	0.01	1.2e-01	-6.5	-6.8	1.3e-11	-0.44	0.10	0.50	FALSE
68	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DNAH10	0.07	0.03	lasso	3	0.05	7.4e-06	-6.5	-6.7	2.1e-11	-0.05	0.03	0.97	FALSE
89	The Cancer Genome Atlas	Thyroid Carcinoma	ZNF664	0.06	0.05	enet	9	0.05	2.8e-05	-6.3	6.7	2.1e-11	0.01	0.03	0.96	FALSE
35	GTEx	Lung	RP11-380L11.4	0.07	0.07	lasso	3	0.07	8.2e-06	-6.5	-6.7	2.3e-11	-0.01	0.01	0.99	FALSE
32	GTEx	Heart Left Ventricle	CCDC92	0.26	0.19	lasso	4	0.21	1.9e-11	-6.4	-6.5	7.9e-11	0.00	0.05	0.95	FALSE
28	GTEx	Esophagus Muscularis	RP11-380L11.4	0.27	0.29	lasso	8	0.27	1.0e-16	-6.5	-6.5	8.8e-11	-0.01	0.03	0.97	FALSE
87	The Cancer Genome Atlas	Thyroid Carcinoma	DNAH10	0.04	0.03	lasso	5	0.02	4.6e-03	-6.9	-6.5	1.1e-10	0.00	0.01	0.92	FALSE
21	GTEx	Colon Sigmoid	RP11-380L11.4	0.21	0.12	lasso	3	0.08	1.1e-03	-6.5	-6.4	1.5e-10	-0.01	0.03	0.93	FALSE
31	GTEx	Heart Atrial Appendage	RP11-380L11.4	0.18	0.11	lasso	7	0.12	6.5e-06	-6.5	-6.4	1.8e-10	0.00	0.03	0.96	FALSE
64	The Cancer Genome Atlas	Glioblastoma Multiforme	CCDC92	0.07	0.02	blup	52	0.04	1.8e-02	-6.2	-6.3	2.2e-10	-0.01	0.02	0.73	FALSE
9	GTEx	Artery Tibial	RP11-380L11.4	0.14	0.12	lasso	4	0.12	2.2e-09	-6.3	-6.3	2.6e-10	0.00	0.04	0.96	FALSE
12	GTEx	Brain Hippocampus	C12orf43	0.37	0.08	lasso	6	0.18	6.3e-05	-1.8	6.3	2.8e-10	0.35	0.07	0.05	FALSE
29	GTEx	Heart Atrial Appendage	CCDC92	0.12	0.11	enet	9	0.11	1.1e-05	-5.4	-6.3	2.8e-10	-0.04	0.03	0.95	FALSE
24	GTEx	Esophagus Mucosa	CCDC92	0.11	0.02	lasso	4	0.02	1.9e-02	-6.4	-6.2	4.4e-10	0.00	0.02	0.95	FALSE
50	GTEx	Thyroid	ZNF664	0.13	0.06	lasso	11	0.08	6.7e-07	-6.2	6.2	4.5e-10	-0.01	0.04	0.96	FALSE
15	GTEx	Breast Mammary Tissue (Female)	CCDC92	0.05	-0.01	enet	2	-0.01	6.2e-01	-6.2	-6.2	4.6e-10	0.00	0.03	0.36	FALSE
67	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C12orf27	0.03	0.01	lasso	4	0.01	1.1e-02	6.2	6.1	8.2e-10	0.23	0.07	0.06	FALSE
39	GTEx	Nerve Tibial	CCDC92	0.16	0.01	enet	6	0.04	6.7e-04	-6.9	-6.0	1.7e-09	0.04	0.01	0.92	FALSE
49	GTEx	Thyroid	CCDC92	0.06	0.03	lasso	3	0.02	1.1e-02	-6.5	-6.0	1.8e-09	0.01	0.02	0.97	FALSE
37	GTEx	Muscle Skeletal	RP11-380L11.4	0.14	0.03	lasso	8	0.03	4.0e-04	-6.3	-6.0	2.3e-09	0.01	0.04	0.96	FALSE
4	GTEx	Adipose Visceral Omentum	CCDC92	0.19	0.02	lasso	8	0.09	3.3e-05	-6.5	-6.0	2.6e-09	0.01	0.04	0.95	FALSE
65	The Cancer Genome Atlas	Glioblastoma Multiforme	WDR66	0.32	0.14	blup	81	0.11	3.4e-04	-5.9	5.9	4.3e-09	0.03	0.30	0.47	FALSE
7	GTEx	Artery Aorta	C12orf43	0.21	0.01	enet	42	0.08	4.6e-05	14.6	-5.8	5.5e-09	-0.44	0.04	0.65	FALSE
5	GTEx	Adipose Visceral Omentum	RP11-380L11.3	0.15	0.03	lasso	5	0.01	1.4e-01	-2.0	-5.7	1.0e-08	0.00	0.05	0.71	FALSE
52	METSIM	Adipose	DNAH10	0.03	0.00	bslmm	475	0.01	3.2e-03	-5.7	-5.6	2.0e-08	-0.03	0.05	0.75	FALSE
72	The Cancer Genome Atlas	Brain Lower Grade Glioma	C12orf65	0.03	0.01	blup	35	0.02	1.6e-03	-4.8	5.6	2.0e-08	-0.04	0.01	0.76	FALSE
38	GTEx	Muscle Skeletal	RP11-347I19.8	0.08	0.06	lasso	4	0.06	2.4e-06	-4.5	5.5	2.9e-08	-0.09	0.96	0.01	FALSE
14	GTEx	Breast Mammary Tissue (Male)	CCDC92	0.06	-0.01	lasso	3	0.00	4.3e-01	-6.3	-5.5	4.0e-08	0.01	0.03	0.25	FALSE
66	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	DNAH10	0.10	0.01	blup	98	0.02	3.7e-03	-6.4	-5.5	4.0e-08	-0.04	0.03	0.81	FALSE
53	METSIM	Adipose	MLXIP	0.08	0.07	enet	25	0.07	2.3e-10	5.3	-5.5	4.3e-08	0.09	0.13	0.87	FALSE
77	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	WDR66	0.16	0.18	lasso	5	0.19	4.3e-13	4.8	5.5	4.6e-08	0.02	0.33	0.67	FALSE
61	The Cancer Genome Atlas	Breast Invasive Carcinoma	C12orf65	0.02	0.00	enet	6	0.01	2.4e-03	-4.7	5.5	4.7e-08	-0.04	0.01	0.53	FALSE
86	The Cancer Genome Atlas	Thyroid Carcinoma	C12orf65	0.05	0.01	blup	35	0.04	1.8e-04	-5.1	5.4	5.6e-08	-0.01	0.01	0.79	FALSE
30	GTEx	Heart Atrial Appendage	AC084018.1	0.34	0.19	enet	9	0.20	3.7e-09	-4.5	5.4	5.7e-08	-0.04	0.97	0.00	FALSE
71	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	WDR66	0.15	0.12	enet	24	0.16	2.1e-09	-4.7	5.4	6.2e-08	0.07	0.78	0.22	FALSE
18	GTEx	Cells Transformed fibroblasts	WDR66	0.39	0.38	lasso	7	0.41	4.5e-33	4.8	5.4	6.6e-08	0.02	1.00	0.00	FALSE
84	The Cancer Genome Atlas	Soft Tissue Sarcoma	CCDC92	0.05	0.03	blup	52	0.03	5.8e-03	-2.2	-5.4	7.4e-08	0.01	0.03	0.70	FALSE
60	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	OGFOD2	0.03	0.02	blup	16	0.01	5.0e-02	-4.9	-5.4	8.1e-08	0.06	0.00	0.86	FALSE
80	The Cancer Genome Atlas	Prostate Adenocarcinoma	RILPL2	0.06	0.01	blup	39	0.03	1.6e-04	-4.6	-5.3	1.3e-07	0.07	0.00	0.66	FALSE
45	GTEx	Skin Sun Exposed Lower leg	ABCB9	0.09	0.08	lasso	5	0.08	4.3e-07	-5.2	-5.3	1.4e-07	0.08	0.03	0.97	FALSE
47	GTEx	Skin Sun Exposed Lower leg	RP11-380L11.4	0.04	0.02	enet	15	0.02	1.9e-02	-6.4	-5.3	1.4e-07	0.01	0.03	0.92	FALSE
19	GTEx	Cells Transformed fibroblasts	ARL6IP4	0.12	0.13	lasso	2	0.12	4.0e-09	-5.2	5.2	1.7e-07	-0.08	0.03	0.97	FALSE
34	GTEx	Liver	ABCB9	0.32	0.32	lasso	3	0.28	1.9e-08	-5.2	-5.2	1.8e-07	0.07	0.04	0.95	FALSE
88	The Cancer Genome Atlas	Thyroid Carcinoma	PITPNM2	0.04	0.03	enet	5	0.05	8.1e-06	-3.9	-5.2	1.8e-07	0.06	0.08	0.91	FALSE
62	The Cancer Genome Atlas	Breast Invasive Carcinoma	WDR66	0.03	0.01	blup	81	0.02	9.8e-05	-5.4	5.2	1.9e-07	0.03	0.37	0.44	FALSE
70	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	C12orf65	0.05	0.04	blup	34	0.05	1.0e-03	-5.0	5.2	2.2e-07	-0.06	0.01	0.84	FALSE