TWAS hub - RNF10

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Visceral Omentum	0.1510	0.0660	0.00760	0.028	NA	0.031	NA	0.011	1.3e-02	NA	9.7e-03	NA	8.1e-02
2	GTEx	Muscle Skeletal	0.0978	0.0348	0.00064	0.056	NA	0.025	NA	0.039	3.6e-06	NA	1.6e-03	NA	9.6e-05
3	YFS	Blood	0.1332	0.0262	0.00000	0.096	0.133	0.136	0.139	0.135	1.2e-29	2.9e-41	2.5e-42	4.4e-43	5.0e-42
4	TCGA	Brain Lower Grade Glioma	0.0251	0.0136	0.00360	0.037	0.021	0.033	NA	0.032	4.5e-05	1.5e-03	9.6e-05	NA	1.3e-04
5	TCGA	Prostate Adenocarcinoma	0.0374	0.0211	0.00560	0.014	0.013	0.012	NA	0.017	1.0e-02	1.5e-02	1.8e-02	NA	5.9e-03
6	TCGA	Thyroid Carcinoma	0.0580	0.0300	0.00035	0.007	0.025	0.014	NA	0.012	6.1e-02	1.7e-03	1.5e-02	NA	2.0e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Average weekly beer plus cider intake	8.7	12.6	21.2	1.6	4.6	0.4	4.2	4.4	3.8
Qualifications: None of the above	6.1	13.1	26.0	1.2	3.9	-2.0	3.3	5.1	4.6
Alcohol usually taken with meals	5.3	8.6	17.1	-1.6	-4.1	0.5	-2.9	-3.3	-3.6
Qualifications: nursing, teaching	4.9	7.6	10.7	-1.9	-3.2	2.8	-2.6	-2.5	-3.3
Qualifications: CSEs or equivalent	4.8	6.4	12.0	-0.0	3.3	-2.9	0.8	2.4	3.5
Smoking Status	4.7	11.1	18.1	-2.6	2.3	4.1	3.6	4.3	2.6
Wheeze or whistling in the chest in last year	4.6	8.1	15.9	0.4	3.3	1.2	4.0	3.3	3.0
Qualifications: College or University degree	4.6	14.6	24.7	-1.4	-4.1	3.9	-3.0	-5.0	-4.4
Worry too long after embarrassment	4.4	7.4	11.2	0.7	3.1	-2.1	3.4	3.0	3.0
Medication: Ventolin 100micrograms inhaler	4.3	5.5	10.6	1.9	2.7	-1.5	2.3	2.1	3.2
Intelligence (Savage-Jansen 2018)	4.1	12.5	28.5	-0.6	-3.6	4.0	-0.3	-5.3	-4.2
Ovarian Cancer	4.1	5.4	12.5	1.4	2.6	-1.2	1.6	2.7	3.5
Schizophrenia vs Biploar Disorder	4.0	5.2	11.0	0.8	2.6	-2.0	1.6	3.3	2.5
Diabetes (mother)	3.7	4.8	11.5	0.8	1.4	3.4	2.3	1.9	2.3
Current tobacco smoking	3.6	5.8	10.7	0.5	2.8	2.0	3.3	2.4	2.4
Seen doctor (GP) for nerves, anxiety, tension or depression	3.6	5.6	12.3	-1.5	2.4	-0.8	2.4	3.5	2.5
Qualifications: O levels/GCSEs or equivalent	3.5	5.5	10.2	1.0	-2.0	0.4	-3.2	-2.8	-3.2
Wears glasses or contact lenses	3.4	3.9	8.6	-0.8	-2.9	-0.3	-1.6	-2.2	-2.6
Relative age of first facial hair	3.3	6.8	14.4	1.2	3.2	-3.8	1.1	2.3	2.9
Shortness of breath walking on level ground	3.2	3.8	7.0	1.0	2.3	-0.5	2.6	2.2	2.2
Average weekly red wine intake	3.2	4.7	11.6	-1.0	-3.4	1.4	-1.4	-2.4	-2.4
Past tobacco smoking	3.1	5.7	13.5	2.1	-2.3	-1.1	-1.7	-3.7	-2.5
Qualifications: A levels/AS levels or equivalent	3.1	6.9	13.8	0.3	-2.9	2.1	-1.7	-3.7	-3.5
Age at first live birth	3.0	5.4	13.5	0.2	-2.7	0.2	-3.7	-2.7	-2.0
Average weekly fortified wine intake	2.9	3.4	7.4	-1.2	-2.7	0.3	-1.9	-2.2	-1.8
Smoking status: Current	2.9	4.6	8.3	0.1	2.5	1.9	2.9	2.2	2.2
Bipolar Disorder (2018)	2.8	4.4	7.1	-1.6	-2.7	2.5	-1.1	-2.1	-2.2
Noisy workplace	2.8	3.5	10.2	-1.2	1.6	-0.3	1.0	3.2	2.4
Neck or shoulder pain in last month	2.7	3.8	7.8	-0.1	2.8	0.6	1.2	2.5	2.6
Overall health rating	2.7	5.8	9.5	0.1	2.8	-1.2	3.1	2.9	2.7
Impedance of arm (right)	2.6	12.2	32.8	-0.7	4.0	-5.7	0.2	4.0	2.9
Number of incorrect matches in round	2.5	4.2	10.3	-1.8	1.7	-1.7	0.1	3.2	2.4
Neuroticism score	2.5	5.2	10.3	-1.1	2.2	-3.2	1.9	2.3	2.5
Medication for pain relief, constipation, heartburn	2.4	4.2	8.5	0.7	-2.5	-0.6	-1.9	-2.9	-2.4
Ever smoked	2.4	4.2	9.9	-1.6	2.3	1.1	1.3	3.1	2.1
Worrier / anxious feelings	2.3	4.4	6.2	-2.1	2.0	-2.5	0.8	2.4	2.3
Primary Biliary Cirrhosis	2.2	3.2	11.6	-3.4	-0.5	2.5	0.4	-0.7	-0.7
Serious illness, injury or assault of a close relative in last 2 years	2.2	2.5	5.0	-1.4	-1.1	1.5	-2.2	-1.0	-1.8
Smoking status: Previous	2.2	3.4	9.1	-2.1	1.7	0.6	0.9	3.0	1.7
Bipolar Disorder (2011)	2.1	2.0	3.9	-0.7	-2.0	1.1	0.2	-2.0	-1.5
Hair/balding pattern: Pattern 4	2.1	5.1	10.6	-0.8	-3.3	1.6	-1.2	-2.8	-2.7
Verbal and Numeric Reasoning (VNR)	2.0	4.9	9.9	-0.5	-2.0	3.0	0.6	-3.2	-2.5
Neuroticism (2016)	2.0	2.9	7.1	-0.9	1.3	-2.2	0.6	2.7	1.6
Sensitivity / hurt feelings	2.0	3.4	13.5	-0.9	1.2	-3.7	0.7	1.2	1.6
Fed-up feelings	2.0	3.7	7.2	0.4	1.9	-1.5	2.7	1.7	2.5
Allergy	2.0	4.6	8.2	-0.8	-2.7	1.0	-2.9	-1.7	-2.8
Medication: Seretide 50 evohaler	2.0	2.3	4.1	-0.9	2.0	-0.3	1.7	1.4	2.0
Financial situation satisfaction	2.0	2.5	5.8	0.1	2.1	-0.6	0.5	2.1	2.4
Impedance of arm (left)	1.9	8.8	25.7	-1.0	2.9	-5.1	-0.3	3.6	2.2
Qualifications: NVQ or HND or HNC or equivalent	1.9	2.3	5.2	-0.9	1.4	-1.8	0.8	2.3	1.4
Diabetes diagnosed by doctor	1.9	3.1	7.4	1.8	0.9	2.4	2.7	0.4	1.3
Friendships satisfaction	1.9	2.4	7.0	-0.7	-2.0	-0.0	-0.7	-2.6	-1.5
Neuroticism (Nagel 2018)	1.8	4.2	7.5	-0.5	1.8	-2.7	2.4	2.2	2.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.8	2.4	6.4	-1.2	1.4	-2.5	0.5	1.1	1.7
Arm fat percentage (right)	1.8	7.1	13.0	-0.6	3.0	-0.9	3.0	3.2	3.6
Breastfed as a baby	1.8	2.2	7.7	1.0	-0.6	2.8	-0.2	-1.7	-1.1
Headache pain in last month	1.8	3.2	4.7	1.0	1.9	2.0	2.2	1.6	1.7
High blood pressure (siblings)	1.8	2.6	4.2	0.8	2.0	-0.6	1.6	2.0	2.0
Body Mass Index (BMI) (2010)	1.7	2.3	4.4	0.0	2.1	0.1	2.0	1.7	1.7
Medication for hormone replacement therapy	1.7	1.9	3.7	1.3	1.2	-0.3	1.2	1.9	1.8
Asthma	1.7	3.3	4.8	1.8	1.7	-1.0	2.2	1.8	2.1
Pain experienced in last month	1.7	2.8	6.2	-0.4	-2.5	0.2	-1.4	-2.0	-2.1
Neuroticism	1.6	3.8	10.1	-1.7	0.8	-3.2	2.1	1.4	1.8
Trunk fat percentage	1.6	6.5	11.8	-0.7	2.4	-1.6	3.1	3.4	2.9
Maternal smoking around birth	1.6	2.3	5.0	0.8	1.0	-1.4	1.7	2.2	1.5
Hayfever, allergic rhinitis or eczema	1.6	3.5	5.9	0.7	2.4	-0.7	2.4	1.9	2.2
Fluid intelligence score	1.6	3.3	7.3	-0.9	-1.6	1.8	0.1	-2.7	-2.4
Medication: Omeprazole	1.6	1.9	4.2	-1.9	1.6	-0.1	0.3	2.0	0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.6	1.9	3.8	-1.0	1.7	-1.9	-0.2	0.9	1.6
Medication: Gliclazide	1.6	1.8	3.8	1.8	0.9	2.0	1.5	0.4	0.9
Pain type(s) experienced in last month: Hip pain	1.6	2.0	3.3	-1.6	0.8	1.2	1.8	1.6	1.3
Ulcerative Colitis (UC)	1.5	2.8	4.5	0.9	-1.1	1.9	-2.1	-1.4	-2.1
HDL Cholesterol	1.5	2.5	5.9	-0.7	-1.8	2.4	-0.9	-1.7	-1.5
Lung FVC	1.5	7.8	15.8	-3.2	-4.0	3.5	0.4	-0.9	-2.8
Chronotype (morning person)	1.5	3.5	10.1	1.4	-0.2	2.2	3.2	-1.4	-1.6
Medication: Metformin	1.5	2.1	4.8	1.8	0.8	1.6	2.2	0.7	0.9
Pack years adult smoking proportion	1.5	2.2	4.6	1.7	1.2	1.5	2.1	1.0	1.3
Diabetes (self-reported)	1.5	2.4	6.0	1.7	1.1	1.7	2.4	0.4	1.1
Depression (self-reported)	1.5	1.8	5.4	-2.3	-0.7	1.8	1.0	0.8	0.1
Tense / ‘highly strung’	1.5	2.4	9.6	-1.0	0.2	-3.1	0.3	1.8	0.5
Gout (self-reported)	1.5	2.0	6.2	-0.4	0.3	2.5	2.4	-0.1	0.0
Emphysema/chronic bronchitis	1.5	1.7	3.2	-0.9	1.4	0.5	1.8	1.5	1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.5	1.7	4.0	0.7	1.8	-0.5	0.1	2.0	1.6
Ever had bowel cancer screening	1.5	1.7	4.9	0.0	0.6	0.9	2.2	1.6	1.3
Asthma (self-reported)	1.5	3.0	4.6	1.4	1.7	-0.8	2.0	1.9	2.2
Ever depressed for a whole week	1.5	1.9	9.1	-3.0	-0.0	1.1	-0.2	-0.9	-0.3
Commuting to job workplace: Cycle	1.5	1.8	4.2	-1.5	-0.8	2.1	-1.5	-0.9	-1.0
Allergy or Eczema	1.4	3.6	10.2	2.6	1.4	-0.0	3.2	1.1	1.3
Nervous feelings	1.4	2.6	8.9	-0.0	1.8	-3.0	0.4	1.3	1.0
Ever unenthusiastic/disinterested for a whole week	1.4	1.8	3.1	-1.8	1.5	0.6	1.0	1.3	1.5
Alcohol intake versus 10 years previously	1.4	2.1	6.5	-0.3	0.8	0.1	1.7	2.5	1.6
Pulse wave reflection index	1.4	1.7	3.0	-0.9	-1.6	1.6	0.9	-1.7	-0.7
Comparative body size at age 10	1.4	3.8	6.6	-1.8	-2.6	1.5	-1.2	-2.1	-2.1
Age at last live birth	1.4	2.0	6.4	0.1	-1.6	0.8	-2.5	-1.3	-1.1
Leg pain on walking	1.4	1.8	2.8	1.1	1.7	-1.6	1.4	0.9	1.2
Medication for cholesterol	1.4	2.2	4.6	-1.3	-1.1	0.5	-2.1	-1.5	-1.7
Medication: Atorvastatin	1.4	1.7	2.6	0.6	1.4	-0.6	1.6	1.6	1.5
Fractured/broken bones in last 5 years	1.4	1.8	4.7	-0.6	1.9	2.2	1.1	0.8	0.6
Medication: Omeprazole (e.g. Zanprol)	1.4	1.7	5.5	-2.3	1.3	-0.4	0.2	1.5	0.9
Worry (Nagel 2018)	1.3	2.7	10.1	-1.5	0.9	-3.2	0.3	1.5	0.8
Irritable Bowel Disease (IBD)	1.3	3.0	4.8	-0.1	-1.6	2.1	-1.6	-1.8	-2.2
Coronary Artery Disease (CAD)	1.3	1.6	5.5	-0.1	1.3	-1.4	-0.3	2.3	0.7
Triglycerides	1.3	2.2	4.2	-0.0	1.6	-2.0	-0.3	1.9	1.7
Hypothyroidism (self reported)	1.3	2.9	15.4	0.5	0.2	-3.9	0.4	0.4	1.2
Stomach or abdominal pain in last month	1.3	1.6	3.2	-1.3	0.9	0.1	1.2	1.5	1.8
Prospective memory result	1.3	1.6	3.6	0.2	1.5	-1.9	0.3	1.4	1.2
Body fat percentage	1.3	5.0	9.4	-0.7	2.1	-0.9	2.9	3.1	2.6
Health satisfaction	1.3	1.7	2.8	1.6	1.5	0.2	1.7	1.2	1.0
Arm fat percentage (left)	1.3	5.4	10.3	-0.8	2.3	-0.4	2.8	2.9	3.2
Risk taking	1.3	1.8	4.7	1.4	1.2	0.1	0.9	2.2	1.5
Schizophrenia (2018)	1.2	2.5	8.8	-1.4	1.6	0.7	0.2	3.0	1.0
Mean Putamen Volume	1.2	1.4	3.5	-0.9	-0.9	-0.4	-1.3	-1.2	-1.9
Rheumatoid Arthritis	1.2	1.6	4.0	0.4	0.5	-2.0	1.6	1.3	1.0
Blood Red Count	1.2	11.2	32.1	-1.6	2.3	-0.0	1.3	5.7	5.1
Diverticular disease/diverticulitis (self-reported)	1.2	1.4	4.8	-2.2	-1.0	-0.4	-1.4	-0.1	-0.9
Had other major operations	1.2	1.4	6.5	-2.5	0.2	0.8	0.9	0.7	0.5
Father’s age at death	1.2	1.6	3.4	-0.7	-1.8	1.4	0.5	-0.9	-1.5
Frequency of tiredness / lethargy in last 2 weeks	1.2	1.9	4.9	-0.0	1.6	-2.2	0.8	0.9	1.5
Falls in the last year	1.2	1.6	5.5	0.3	1.5	0.2	2.3	-0.1	1.2
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	2.9	-0.8	-1.5	-0.1	-1.6	-0.4	-1.7
Mood swings	1.2	2.2	4.0	-0.4	1.4	-1.9	1.6	1.1	2.0
Long-standing illness, disability or infirmity	1.2	1.8	3.7	0.4	0.5	1.9	1.6	1.6	1.3
Mineral and other dietary supplements	1.2	1.6	4.5	1.1	-0.8	-2.1	-1.5	-0.4	-0.8
Osteoporosis (self-reported)	1.2	1.5	5.7	-2.4	-1.1	0.3	-1.1	-0.4	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.2	2.5	6.4	-1.4	-2.5	1.6	0.2	-1.1	-1.8
Commuting to job workplace: Public transport	1.2	1.4	5.6	0.6	-0.4	0.7	1.1	-2.4	-0.7
Illnesses of father: High blood pressure	1.2	1.5	4.2	-0.7	2.0	-0.8	-0.1	1.3	1.4
Diastolic blood pressure, automated reading	1.2	3.7	8.1	2.9	2.2	-0.9	1.2	1.5	2.1
Unable to work because of sickness or disability	1.2	1.6	4.8	0.5	0.2	2.2	1.9	0.9	0.4
Alcohol drinker status: Previous	1.2	1.3	3.5	-1.9	-0.8	0.3	-0.7	-1.8	-0.3
Pack years of smoking	1.2	1.8	5.0	1.4	0.7	1.5	2.2	0.6	1.0
Impedance of whole body	1.2	6.0	17.6	-1.5	2.3	-4.2	-0.5	3.0	1.1
Lupus	1.1	1.6	5.0	0.0	-1.4	0.7	-0.8	-2.2	-1.3
Lung FEV1/FVC ratio	1.1	5.7	12.0	2.2	2.9	-0.7	2.1	2.0	3.5
Supplements: Zinc	1.1	1.2	3.7	-1.9	-0.3	1.1	-1.5	0.2	-0.3
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	4.5	-0.6	0.6	2.1	1.2	0.6	0.4
Hayfever/allergic rhinitis (self-reported)	1.1	1.5	3.9	0.1	1.1	-1.1	1.1	1.2	2.0
Number of full brothers	1.1	1.3	2.1	0.4	1.5	-0.3	1.4	1.4	1.3
Chest pain or discomfort	1.1	1.6	4.4	-1.1	1.2	0.3	1.3	2.1	0.9
Number of self-reported non-cancer illnesses	1.1	1.9	3.6	-0.9	1.2	0.4	1.9	1.5	1.7
Supplements: Fish oil (including cod liver oil)	1.1	1.5	3.3	0.2	1.2	1.5	1.8	1.0	0.9
Alzheimer’s Disease (including proxy)	1.0	1.4	2.6	1.2	0.5	1.1	1.6	0.9	1.5
Type 2 Diabetes (T2D) (2012)	1.0	1.2	4.4	-2.1	-0.3	-0.5	-1.3	0.4	0.5
Townsend deprivation index at recruitment	1.0	1.3	3.3	-1.2	1.2	0.7	1.0	1.8	0.6
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.4	7.4	-0.5	-1.3	-1.6	-2.7	-1.1	-1.0
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.3	6.1	0.7	-1.5	-0.8	-2.5	-1.5	-1.3
Medication: Simvastatin	1.0	1.4	4.5	1.1	0.1	2.1	1.4	0.3	0.6
Forced vital capacity (FVC), Best measure	1.0	3.5	9.2	-1.6	-3.0	0.5	-0.9	-0.9	-2.7
Exposure to tobacco smoke outside home	1.0	1.3	3.4	-0.1	1.8	-0.7	0.9	1.1	1.3
Loneliness, isolation	1.0	1.4	2.4	-1.0	0.8	-0.7	1.4	1.3	1.6
Supplements: Calcium	1.0	1.1	2.1	-0.1	-1.4	1.2	0.4	-1.2	-1.1
Heart disease (siblings)	1.0	1.2	2.0	0.9	1.0	-0.1	1.3	1.3	1.4
Depressed Affect (Nagel 2018)	0.9	1.9	6.7	0.0	0.7	-1.3	2.6	0.6	1.3
Crohns Disease (2017)	0.9	2.0	2.9	-1.1	-1.7	1.7	-0.5	-1.6	-1.5
Ever had hysterectomy (womb removed)	0.9	1.0	2.9	-0.3	1.7	-0.1	0.3	1.0	1.4
Medication: Co-codamol	0.9	1.1	2.6	-1.6	0.3	-0.8	-1.0	1.0	1.0
Diabetes (father)	0.9	1.1	1.7	1.1	1.0	-0.3	0.9	1.3	1.3
Relative age voice broke	0.9	1.3	2.8	0.7	1.7	-1.5	0.8	0.9	1.1
Taking other prescription medications	0.9	1.4	3.7	-1.9	0.1	-0.1	1.2	1.4	1.1
Had menopause	0.9	1.1	4.1	1.0	-1.1	0.2	2.0	-0.3	-0.2
Illnesses of siblings	0.9	1.3	3.0	-1.4	-0.7	0.1	-1.7	-1.3	-0.8
Number of live births	0.9	1.3	2.9	0.4	1.4	0.7	1.7	1.4	0.9
Birth weight of first child	0.9	1.6	6.5	-2.6	0.2	-0.9	-0.9	0.8	-0.8
Hypothyroidism/myxoedema (self-reported)	0.9	1.8	9.4	0.4	0.2	-3.1	0.3	0.0	0.9
Arm fat-free mass (right)	0.9	4.6	11.0	0.4	-3.3	1.9	0.4	-2.5	-2.6
Medication: Ibuprofen	0.9	1.1	3.1	0.1	1.8	0.4	1.0	1.3	0.9
Arm predicted mass (right)	0.9	4.6	9.8	0.4	-3.1	2.2	0.4	-2.5	-2.5
Alcohol intake frequency.	0.9	2.1	8.6	0.3	0.6	-2.9	-0.9	0.6	1.6
Miserableness	0.9	1.6	3.2	0.2	1.0	-1.4	1.8	0.8	1.6
Guilty feelings	0.9	1.4	3.0	-0.8	1.1	-0.0	1.3	1.7	1.3
Tinnitus: Yes, now most or all of the time	0.9	1.0	2.1	1.4	0.7	-0.4	0.4	1.4	1.1
Ever had prostate specific antigen (PSA) test	0.9	1.1	2.4	-0.8	-0.7	-1.3	-1.2	-1.6	-0.3
Age started oral contraceptive pill	0.9	1.1	2.9	0.9	0.2	-1.1	1.7	0.7	1.1
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	3.0	-1.3	-0.9	-0.9	-1.7	-0.8	-0.2
Ever used hormone-replacement therapy (HRT)	0.8	1.0	3.1	-0.6	0.5	-0.0	1.2	1.8	0.8
Angina	0.8	1.1	2.4	1.1	0.5	1.0	1.1	1.6	0.6
Chronic bronchitis/emphysema (father)	0.8	0.9	2.7	-1.6	-0.0	-1.6	-0.0	0.3	0.6
Forced vital capacity (FVC)	0.8	3.0	7.8	-1.2	-2.8	0.1	-0.8	-1.2	-2.6
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.1	2.5	0.1	1.6	0.6	0.8	1.3	1.1
Lung cancer (father)	0.8	1.0	2.5	0.1	-1.6	-1.4	-1.0	-0.5	-0.4
Exposure to tobacco smoke at home	0.8	0.9	2.2	0.7	1.0	-1.5	0.5	0.6	1.1
Birth weight	0.8	1.8	4.1	-1.5	-0.9	2.0	1.1	-0.8	-1.4
Angina (self-reported)	0.8	1.1	2.5	1.0	0.4	1.0	1.1	1.6	0.6
Commuting to job workplace: Car/motor vehicle	0.8	1.0	3.9	-0.4	0.4	0.0	0.9	2.0	0.8
Supplements: Vitamin C	0.8	1.0	4.3	-2.1	-0.9	-0.6	-0.1	0.3	0.2
Knee pain experienced in last month	0.8	1.3	1.9	-0.8	1.3	-0.2	1.4	1.3	1.2
Average weekly champagne plus white wine intake	0.8	1.0	2.5	-0.2	-1.1	1.2	-0.5	-1.6	-0.8
Number of operations (self-reported)	0.8	1.2	3.5	-1.9	0.2	1.3	0.6	0.9	0.7
Bipolar Disorder or Schizophrenia	0.7	1.8	4.7	-2.2	-0.4	2.1	-0.5	1.0	-0.5
Schizophrenia (2014)	0.7	1.7	4.8	-1.5	0.9	0.8	0.5	2.2	1.1
Blood Eosinophil Count	0.7	5.3	11.4	3.4	1.9	-3.2	1.4	2.0	1.0
Waist Hip Ratio (WHR)	0.7	3.3	6.9	-0.2	1.9	1.0	2.6	2.2	1.9
Systolic Blood Pressure	0.7	3.6	6.7	2.5	-0.5	-2.6	-2.4	-1.1	-1.0
Type 2 Diabetes (T2D) (2018)	0.7	1.4	3.2	1.7	0.1	1.8	1.3	-0.5	0.2
Hearing difficulty/problems: Yes	0.7	1.1	4.4	1.2	0.2	0.4	2.1	0.2	0.6
Supplements: Glucosamine	0.7	0.9	4.1	-0.9	0.3	2.0	0.1	-0.3	0.3
Body mass index (BMI)	0.7	2.8	7.2	-0.7	0.6	2.0	2.7	1.3	1.8
Trunk fat mass	0.7	3.0	7.2	-0.6	1.2	-1.0	2.7	2.2	1.8
Medication: Ramipril	0.7	0.9	1.6	0.6	1.1	-0.4	1.3	1.2	0.7
Trunk fat-free mass	0.7	4.0	8.8	0.8	-3.0	1.1	-0.2	-2.7	-2.5
Pulse rate	0.7	1.2	4.5	2.1	1.1	0.0	1.1	0.0	0.6
Arm fat mass (right)	0.7	3.0	7.8	-0.4	1.4	0.1	2.8	1.9	2.2
Trunk predicted mass	0.7	4.0	8.7	0.8	-2.9	1.1	-0.2	-2.7	-2.5
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	2.1	-0.4	-0.7	0.9	1.4	-1.5	-0.2
Eye problems/disorders: None of the above	0.7	0.8	2.1	-0.7	-0.5	1.5	-0.8	-0.8	-0.8
Breast cancer (self-reported)	0.7	0.9	1.7	-0.2	-1.3	0.7	-0.2	-1.2	-1.3
Mother’s age at death	0.7	0.9	3.2	-0.1	-0.3	1.2	-0.5	-1.8	-0.4
Medication: Bendroflumethiazide	0.7	1.0	3.5	1.9	-0.8	-0.7	-0.4	-1.0	-0.5
Medication: Lisinopril	0.7	0.8	1.6	-0.0	-0.5	-1.2	-1.3	-1.0	-0.9
Cholesterol lowering medication	0.7	1.1	2.7	0.5	-0.4	1.6	1.6	0.4	0.9
Depression (Nagel 2018)	0.6	0.9	2.0	-1.2	0.4	-1.4	0.7	0.8	0.9
Alzheimer’s Disease (in mother)	0.6	0.7	2.0	1.4	-0.8	1.0	0.5	-0.2	0.5
Major Depression (MDD)	0.6	0.7	3.4	-0.6	-0.1	1.8	0.6	-0.2	-0.3
Crohns Disease (2012)	0.6	1.0	2.0	-1.4	-1.4	0.2	-0.1	-1.0	-0.9
HbA1C	0.6	0.6	1.2	-1.1	-1.0	0.9	-0.4	-0.6	-0.6
Ulcerative Colitis	0.6	0.8	2.9	0.2	-0.1	0.2	-1.7	-0.5	-1.3
BMI	0.6	3.7	11.8	-0.3	0.8	1.9	3.4	1.3	2.1
Height	0.6	11.6	50.6	2.5	-2.4	-7.1	-1.2	0.7	-2.3
Respiratory disease	0.6	1.3	4.2	1.1	0.7	1.1	2.0	0.7	0.5
Average weekly spirits intake	0.6	0.7	2.0	0.6	0.1	1.4	0.6	-1.2	-0.4
Vitamin and mineral supplements	0.6	0.9	4.1	2.0	0.1	-0.5	-0.3	-0.6	-0.6
Age when periods started (menarche)	0.6	1.3	3.0	0.6	-1.4	-0.0	0.6	-1.5	-1.7
Serious illness, injury or assault to yourself	0.6	0.7	1.8	-1.3	-0.3	1.3	-0.3	-0.3	-0.7
Hearing difficulty/problems with background noise	0.6	0.9	3.4	0.2	0.6	-0.8	1.9	0.2	0.9
Hair/balding pattern: Pattern 3	0.6	0.8	1.8	-0.1	-1.4	1.2	-1.0	-0.7	-0.5
Happiness	0.6	0.7	2.1	1.5	0.7	-1.2	0.5	-0.1	0.5
Standing height	0.6	5.5	15.2	0.7	-2.5	-3.9	-1.2	-1.4	-2.9
Medication: Paracetamol	0.6	1.1	2.3	-0.6	1.5	0.8	0.9	0.6	1.4
Leg fat percentage (right)	0.6	2.2	4.8	-0.9	1.1	0.2	2.2	2.1	1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	2.4	-0.7	0.4	-0.5	1.5	1.1	0.6
Medication: Allopurinol	0.6	0.7	2.4	-0.1	0.7	1.0	1.6	0.4	0.6
Mean time to correctly identify matches	0.6	1.2	4.1	-2.0	-0.2	0.3	0.1	0.7	1.5
Heart disease (mother)	0.6	0.7	1.4	-0.6	-0.9	1.0	1.2	-0.7	-0.1
Whole body fat mass	0.6	2.6	8.2	-0.2	0.9	-0.2	2.9	1.9	1.6
Comparative height size at age 10	0.6	3.4	7.7	0.2	-2.1	-2.8	-2.1	-0.1	-1.9
Medication: Aspirin	0.6	0.8	2.3	0.2	-0.2	0.0	1.1	1.5	1.1
Arm fat mass (left)	0.6	2.5	7.5	-0.5	1.0	0.2	2.7	1.6	1.9
Leg fat percentage (left)	0.6	2.0	5.0	-1.2	0.7	0.4	2.2	1.7	1.4
Alzheimer’s Disease (in father)	0.5	0.6	0.9	0.8	0.5	-0.6	1.0	0.8	0.8
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	1.6	-1.3	-0.8	1.0	0.1	-0.2	-0.8
Waist circumference	0.5	1.8	7.2	0.2	0.4	0.8	2.7	1.1	1.3
Heart attack	0.5	0.6	1.9	0.0	-0.5	-0.6	0.9	1.4	0.4
Medication: Cholesterol lowering	0.5	0.7	1.0	0.9	0.7	0.8	1.0	0.9	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.5	4.4	-1.4	-2.1	0.3	-0.4	-0.6	-1.5
Loud music exposure frequency	0.5	0.6	2.6	0.3	0.2	1.6	0.7	-0.5	0.2
Blood clot in the leg (DVT)	0.5	0.7	1.4	-1.0	-0.4	-1.2	-1.1	-0.4	0.4
Number of children fathered	0.5	0.6	2.7	-0.3	-0.5	-0.7	0.2	1.6	-0.2
Number of full sisters	0.5	0.6	1.2	-1.1	-0.5	0.8	0.4	1.0	-0.2
Illness, injury, bereavement, stress in last 2 years	0.5	0.7	2.0	0.8	0.4	-0.0	1.4	0.8	0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	4.3	0.7	-0.1	-2.1	-1.1	-0.6	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	1.9	-0.9	-0.8	-1.2	-1.4	-0.1	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	2.7	1.6	-0.5	-0.4	0.5	0.5	-0.3
Back pain experienced in last month	0.5	0.8	1.8	0.1	0.8	1.3	0.6	1.4	0.4
Osteoarthritis (self-reported)	0.5	0.7	2.7	1.1	0.0	0.3	1.6	0.4	0.1
Illnesses of father: None of the above (group 1)	0.5	0.6	1.2	1.1	-1.0	0.2	-0.3	-0.4	-1.1
Ever taken oral contraceptive pill	0.5	0.6	1.6	0.4	1.2	1.3	0.3	-0.1	0.6
Hearing aid user	0.5	0.6	1.9	0.4	-0.1	1.4	1.0	0.7	0.5
Arm fat-free mass (left)	0.5	2.5	5.2	0.8	-2.3	1.3	0.9	-1.8	-1.9
Heart attack/myocardial infarction (self-reported)	0.5	0.7	1.8	0.5	-0.3	-0.9	1.0	1.3	0.6
Reaction Time	0.4	0.8	1.7	-1.2	0.3	-0.4	-0.7	0.9	1.3
Blood White Count	0.4	3.3	11.0	1.3	1.7	-3.3	-0.4	1.0	1.7
Hand grip strength (left)	0.4	1.1	2.8	1.7	0.9	-0.8	-0.3	1.1	0.9
Number of treatments/medications taken	0.4	0.8	3.0	-1.7	0.4	-0.7	0.1	0.6	0.6
Systolic blood pressure, automated reading	0.4	1.3	4.7	2.2	0.3	-1.6	-0.2	0.5	0.4
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	1.3	0.4	0.4	0.0	1.1	0.4	1.0
Impedance of leg (right)	0.4	2.1	6.5	-1.1	0.8	-2.6	-1.1	1.6	-0.8
Hand grip strength (right)	0.4	1.0	4.1	2.0	0.7	-0.3	0.5	0.5	0.8
Multivitamins +/- minerals	0.4	0.5	2.3	-1.5	-0.1	0.9	-0.2	-0.1	0.3
High blood pressure (mother)	0.4	0.6	1.1	-0.7	0.2	-1.0	-0.9	-0.9	-0.2
Impedance of leg (left)	0.4	1.9	5.5	-1.6	0.4	-2.3	-0.9	1.3	-0.9
Leg fat mass (right)	0.4	1.4	4.9	-0.5	0.4	0.5	2.2	1.4	1.0
Pulse rate, automated reading	0.4	1.2	2.1	1.4	1.0	1.0	1.3	-0.6	1.0
Medication: Aspirin	0.4	0.5	1.5	0.2	-0.5	0.4	1.0	1.2	0.7
Eye problems/disorders: Cataract	0.4	0.5	0.9	0.5	0.2	-0.5	1.0	1.0	0.8
Whole body water mass	0.4	2.3	5.0	0.9	-2.2	1.0	0.4	-2.0	-1.7
High cholesterol (Self-reported)	0.4	0.6	3.7	-0.0	-0.1	1.9	0.2	0.3	0.1
Medication: Paracetamol	0.4	0.6	1.4	-0.8	1.2	0.3	0.6	0.2	1.0
Alcohol drinker status: Never	0.4	0.4	1.2	0.8	0.1	-1.1	-0.8	0.1	-0.3
Irritability	0.4	0.6	2.1	-0.0	0.5	-1.5	0.6	0.8	0.6
Basal cell carcinoma (self-reported)	0.4	0.5	1.0	-0.7	-0.8	-0.7	-0.6	-0.3	-1.0
Arm predicted mass (left)	0.4	2.2	4.6	0.2	-2.1	1.5	0.9	-1.6	-1.7
LDL Cholesterol	0.3	0.5	1.8	-0.8	-0.6	0.3	-1.3	-0.2	0.1
Heel T-Score	0.3	2.3	8.0	2.8	0.1	-1.2	-2.0	0.6	0.4
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	0.7	-0.7	0.3	-0.3	-0.6	0.8	0.6
Medication: Atenolol	0.3	0.4	1.1	-0.1	0.1	0.4	-1.0	0.8	0.6
Mouth/teeth dental problems	0.3	0.5	1.4	0.8	-0.1	-0.5	-1.2	0.6	-0.3
Time employed in main current job	0.3	0.4	1.7	1.3	-0.1	-0.0	-0.7	-0.5	-0.2
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	3.3	-0.5	-1.8	-0.1	-0.3	-0.7	-1.3
Mouth/teeth dental problems: Dentures	0.3	0.5	1.0	-0.7	1.0	0.8	0.3	0.5	0.6
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.7	0.9	0.6	0.2	0.6	0.5	0.8
Medication: Amlodipine	0.3	0.4	1.5	-0.9	-0.0	1.2	0.1	0.1	-0.3
Pulse wave peak to peak time	0.3	0.4	0.8	0.4	-0.4	-0.5	-0.9	0.5	-0.8
Mouth/teeth dental problems: Loose teeth	0.3	0.4	0.9	1.0	-0.5	0.3	0.7	-0.6	-0.5
Migraine (self-reported)	0.3	0.4	1.2	-0.3	0.1	1.1	-0.8	-0.4	-0.4
Illnesses of siblings: Diabetes	0.3	0.4	0.9	-0.2	-0.6	0.7	0.6	0.9	0.3
Whole body fat-free mass	0.3	1.9	4.4	0.9	-2.1	0.8	0.5	-1.8	-1.5
Leg fat mass (left)	0.3	1.3	5.2	-0.3	0.2	0.6	2.3	1.0	0.9
Fasting Glucose	0.2	0.3	0.5	-0.1	-0.7	-0.2	0.2	-0.7	-0.7
Blood Platelet Count	0.2	2.2	5.5	2.3	0.4	-1.7	-1.7	-0.6	-1.1
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.9	-0.6	0.2	0.1	0.9	0.1	0.4
Sitting height	0.2	1.4	3.5	1.2	-1.5	-0.2	0.5	-1.1	-1.9
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.4	1.2	0.5	0.6	-1.1	0.2	0.4	0.5
Hair/balding pattern: Pattern 2	0.2	0.3	0.8	-0.9	0.6	-0.5	0.6	-0.3	-0.2
Financial difficulties in last 2 years	0.2	0.3	0.7	-0.8	-0.1	0.5	0.1	0.4	0.7
Pain all over the body in last month	0.2	0.2	0.6	-0.1	0.8	-0.3	0.0	-0.2	-0.5
Weight	0.2	0.8	3.8	-0.2	-0.7	0.2	2.0	0.4	0.3
Medication: Lansoprazole	0.2	0.2	1.0	0.4	-0.1	-0.4	-0.2	0.1	1.0
Pulse wave Arterial Stiffness index	0.2	0.2	0.4	-0.5	0.0	0.3	0.6	-0.6	0.4
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.5	-0.7	-0.7	0.6	0.3	-0.3	-0.6
Glaucoma (self-reported)	0.2	0.2	0.8	0.9	0.0	0.4	0.3	-0.3	-0.1
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.7	-0.3	-0.2	-0.3	0.4	0.8	0.4
Had major operations	0.2	0.2	0.9	0.9	0.3	0.1	0.3	-0.1	0.1
Family relationship satisfaction	0.2	0.3	1.1	-0.2	0.0	-1.0	-0.1	-0.6	0.4
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.6	-0.6	0.2	-0.7	-0.8	0.6	0.3
Medication: Blood pressure	0.2	0.4	1.5	1.2	-0.1	0.1	1.0	-0.1	0.2
Basal metabolic rate	0.2	1.2	3.1	0.7	-1.7	0.6	0.7	-1.3	-1.1
Vascular/heart problems diagnosed by doctor	0.2	0.5	1.1	-0.4	-0.9	-0.2	-0.6	-1.0	-0.6
Age at First Birth	0.1	0.2	0.7	0.9	0.2	-0.2	-0.1	-0.3	0.4
Cardiovascular Disease	0.1	0.3	0.8	-0.7	-0.0	0.6	-0.9	-0.3	0.0
Hair Pigment	0.1	2.5	3.8	1.8	2.0	1.5	1.8	1.3	0.6
Tanning	0.1	0.9	2.5	0.7	-0.1	1.4	1.6	0.5	0.2
Severe depression (siblings)	0.1	0.2	0.4	0.1	-0.5	-0.2	-0.5	-0.2	-0.6
Leg fat-free mass (left)	0.1	0.5	1.1	1.0	-0.7	0.2	1.1	-0.5	-0.0
High blood pressure	0.1	0.4	1.1	0.3	1.1	-0.1	0.4	0.7	0.6
Medication: Levothyroxine sodium	0.1	0.2	1.0	0.5	-0.1	-1.0	0.1	-0.1	0.3
Leg predicted mass (left)	0.1	0.5	1.1	1.0	-0.8	0.2	1.1	-0.5	-0.0
Hip circumference	0.1	0.6	2.1	-0.3	-1.4	0.1	1.0	-0.6	-0.5
Illnesses of mother	0.1	0.1	0.4	0.2	-0.1	0.1	0.2	0.3	-0.6
Length of working week for main job	0.1	0.1	0.2	0.3	0.3	-0.1	0.3	-0.4	0.4
Peak expiratory flow (PEF)	0.1	0.3	0.7	0.8	0.1	-0.1	0.5	0.2	0.7
Medication: Blood pressure	0.1	0.1	0.4	0.3	0.2	-0.5	-0.6	-0.1	0.2
Suffer from ‘nerves’	0.1	0.2	0.5	-0.5	0.1	-0.7	0.7	-0.1	0.2
Leg fat-free mass (right)	0.1	0.6	1.1	0.8	-1.0	0.3	1.1	-0.7	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.5	-0.1	-0.4	0.7	-0.3	0.0	-0.0
Commuting to job workplace: Walk	0.1	0.1	0.2	-0.4	0.5	-0.3	-0.0	-0.3	0.2
Leg predicted mass (right)	0.1	0.6	1.2	0.9	-1.0	0.2	1.1	-0.7	-0.1
Eye problems/disorders: Glaucoma	0.1	0.1	0.6	0.8	-0.0	0.2	0.2	0.2	0.1
Myopia	0.1	0.2	0.6	0.4	-0.3	-0.8	-0.2	-0.3	-0.3
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Hypertension (Self-reported)	0.0	0.1	0.2	0.2	0.5	0.2	-0.2	0.3	0.1
Illnesses of father: Heart disease	0.0	0.0	0.0	0.1	-0.0	-0.1	0.1	-0.1	0.2

Hub : Genes

RNF10

Models

Trait associations