Hub : Genes

CABP1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Skin Sun Exposed Lower leg 0.1290 0.0450 0.00051 0.002 NA 0.059 NA 0.022 0.20000 NA 1.1e-05 NA 0.0058
2 TCGA Lung Adenocarcinoma 0.0572 0.0341 0.00320 0.027 0.024 0.008 NA 0.015 0.00034 0.00068 3.5e-02 NA 0.0056

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 1.1 1.7 3.1 0.5 1.8
Bipolar Disorder or Schizophrenia 0.1 0.3 0.4 -0.5 -0.6
Depressed Affect (Nagel 2018) 0.8 1.7 3.1 0.6 1.8
Depression (Nagel 2018) 0.5 0.7 1.2 1.1 0.5
Intelligence (Savage-Jansen 2018) 4.9 15.0 22.5 2.8 4.7
Neuroticism (Nagel 2018) 0.4 0.9 1.8 -1.4 0.3
Schizophrenia (2018) 1.4 2.9 4.6 -1.1 -2.1
Schizophrenia vs Biploar Disorder 4.4 5.7 6.0 -2.3 -2.5
Worry (Nagel 2018) 0.6 1.2 2.4 -1.5 0.0
Alzheimer’s Disease (in mother) 0.2 0.2 0.3 0.5 0.5
Alzheimer’s Disease (in father) 0.7 0.7 0.9 -1.0 -0.7
Alzheimer’s Disease (including proxy) 0.0 0.1 0.1 0.1 0.3
Crohns Disease (2017) 0.7 1.5 2.8 1.7 0.3
Irritable Bowel Disease (IBD) 0.4 1.0 1.8 1.4 -0.4
Ulcerative Colitis (UC) 0.4 0.8 1.3 0.6 -1.1
Major Depression (MDD) 1.4 1.6 3.3 0.1 1.8
Reaction Time 0.3 0.5 0.7 -0.8 -0.6
Verbal and Numeric Reasoning (VNR) 3.7 8.8 12.0 2.4 3.5
Breast Cancer 0.0 0.0 0.0 0.0 0.0
Ovarian Cancer 1.4 1.8 1.8 -1.4 -1.3
Prostate Cancer 0.0 0.0 0.0 0.0 0.0
Age at First Birth 1.4 2.1 4.0 2.0 -0.4
Bipolar Disorder (2011) 5.0 4.9 6.7 1.8 2.6
Body Mass Index (BMI) (2010) 0.3 0.4 0.8 0.9 -0.1
Coronary Artery Disease (CAD) 4.4 5.3 5.3 -2.3 -2.3
Crohns Disease (2012) 0.2 0.3 0.5 0.7 0.3
Mean Putamen Volume 1.2 1.4 2.0 1.4 0.9
Fasting Glucose 0.7 0.9 1.1 0.8 1.1
HbA1C 0.4 0.4 0.6 -0.8 0.4
HDL Cholesterol 0.5 0.9 1.2 -1.1 0.8
LDL Cholesterol 0.6 0.9 1.3 -0.7 -1.1
Lupus 1.6 2.4 4.5 0.5 2.1
Neuroticism (2016) 1.9 2.7 3.5 -1.9 -1.4
Primary Biliary Cirrhosis 0.3 0.5 0.9 1.0 -0.0
Rheumatoid Arthritis 0.2 0.3 0.6 -0.1 -0.8
Schizophrenia (2014) 1.6 3.5 5.6 -1.2 -2.4
Triglycerides 0.7 1.2 2.1 -0.6 -1.5
Type 2 Diabetes (T2D) (2012) 1.1 1.3 2.2 -0.6 -1.5
Ulcerative Colitis 0.1 0.2 0.4 0.3 -0.6
Blood Eosinophil Count 0.3 2.3 4.6 2.1 0.1
Blood Platelet Count 0.8 9.6 15.9 4.0 1.8
Blood Red Count 12.6 122.0 154.3 -12.4 -9.5
Blood White Count 0.6 4.7 9.4 3.1 -0.1
Heel T-Score 0.9 7.2 8.8 -2.4 -3.0
BMI 0.6 3.3 6.6 2.6 -0.1
Height 0.4 8.3 15.7 -0.9 -4.0
Waist Hip Ratio (WHR) 0.0 0.1 0.2 -0.3 -0.4
Systolic Blood Pressure 0.3 1.4 2.6 0.4 1.6
Smoking Status 2.8 6.8 13.5 -0.1 -3.7
Allergy or Eczema 0.7 1.9 3.8 0.0 1.9
Cardiovascular Disease 0.1 0.4 0.8 -0.2 0.9
Hypothyroidism (self reported) 0.5 1.2 2.3 -0.3 1.5
Respiratory disease 0.6 1.4 2.0 1.4 -0.9
Type 2 Diabetes (T2D) (2018) 0.8 1.6 2.3 1.5 0.9
Lung FEV1/FVC ratio 0.1 0.3 0.7 -0.8 0.1
Lung FVC 2.2 11.4 16.2 -2.6 -4.0
Neuroticism 0.1 0.2 0.4 0.2 0.7
Chronotype (morning person) 2.3 5.3 9.9 -0.8 3.2
Hair Pigment 0.1 1.7 2.5 -1.6 -1.0
Tanning 0.2 1.8 2.7 -1.0 -1.6
Hand grip strength (left) 0.7 1.8 3.1 -0.7 -1.8
Number of treatments/medications taken 0.2 0.3 0.5 0.7 -0.3
Average weekly spirits intake 1.6 2.0 2.4 1.5 1.2
Sensitivity / hurt feelings 0.4 0.7 1.0 0.6 1.0
Frequency of depressed mood in last 2 weeks 0.3 0.4 0.8 0.3 0.9
Hearing difficulty/problems: Yes 0.2 0.3 0.5 -0.7 0.1
Relative age of first facial hair 0.7 1.4 2.8 -0.1 1.7
Other serious medical condition/disability diagnosed by doctor 1.0 1.4 2.5 -1.6 -0.4
Ever used hormone-replacement therapy (HRT) 2.4 3.0 4.1 -2.0 -1.4
Ever had hysterectomy (womb removed) 0.2 0.2 0.4 0.6 -0.0
Systolic blood pressure, automated reading 0.2 0.6 0.8 -0.9 -0.6
Eye problems/disorders: Diabetes related eye disease 0.3 0.4 0.4 0.7 0.5
Angina 3.0 4.0 5.5 -1.6 -2.3
Medication for hormone replacement therapy 1.3 1.4 2.6 -0.4 -1.6
Vitamin and mineral supplements 0.0 0.0 0.1 0.2 -0.1
Supplements: Zinc 0.9 1.0 1.9 -1.4 -0.1
Medication: Co-codamol 0.9 1.0 1.4 -1.2 -0.8
Medication: Metformin 0.7 1.0 1.7 1.3 -0.5
Diabetes (father) 1.8 2.3 4.2 2.1 -0.5
Diabetes (mother) 3.8 4.9 8.2 -1.3 -2.9
Severe depression (siblings) 1.2 1.3 1.6 1.3 1.0
Pack years adult smoking proportion 0.2 0.3 0.4 -0.4 -0.6
Impedance of leg (right) 0.4 1.9 3.4 -1.8 -0.7
Leg fat-free mass (left) 0.6 3.1 6.2 2.5 0.1
Trunk fat percentage 0.3 1.3 2.5 0.2 -1.6
Hand grip strength (right) 0.1 0.1 0.3 0.1 -0.5
Townsend deprivation index at recruitment 1.3 1.8 3.2 -0.6 -1.8
Current tobacco smoking 0.1 0.2 0.3 0.6 -0.4
Average weekly fortified wine intake 1.1 1.2 2.3 1.5 -0.4
Maternal smoking around birth 1.3 1.9 3.5 0.6 -1.9
Fed-up feelings 0.6 1.0 1.5 0.7 1.2
Frequency of unenthusiasm / disinterest in last 2 weeks 2.1 2.9 4.0 2.0 1.3
Relative age voice broke 0.7 1.0 1.7 0.6 1.3
Taking other prescription medications 0.6 0.9 1.8 -0.2 -1.4
Age when periods started (menarche) 2.1 5.1 7.1 1.7 2.7
Bilateral oophorectomy (both ovaries removed) 0.6 0.7 1.4 -0.1 -1.2
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.3 0.5 0.2 -0.7
Tinnitus: Yes, but not now, but have in the past 0.4 0.4 0.7 -0.8 -0.5
Qualifications: CSEs or equivalent 2.0 2.7 2.8 1.7 1.6
Serious illness, injury or assault to yourself 0.2 0.3 0.3 -0.5 -0.6
High blood pressure 0.2 0.4 0.6 -0.8 0.5
Hayfever, allergic rhinitis or eczema 0.5 1.0 1.9 0.3 1.4
Multivitamins +/- minerals 0.6 0.8 1.1 1.0 0.7
Stomach or abdominal pain in last month 0.3 0.4 0.6 0.4 -0.8
Supplements: Glucosamine 0.4 0.5 0.7 -0.5 0.9
Diverticular disease/diverticulitis (self-reported) 0.4 0.5 0.9 -0.1 -0.9
Medication: Atenolol 0.5 0.6 1.0 -0.5 -1.0
Medication: Levothyroxine sodium 0.1 0.1 0.3 -0.5 0.1
Sitting height 0.3 2.1 4.1 2.0 -0.5
Chronic bronchitis/emphysema (father) 0.4 0.4 0.8 0.9 -0.1
High blood pressure (mother) 1.0 1.4 2.2 -0.8 1.5
Body mass index (BMI) 0.3 1.1 1.3 1.1 -1.0
Impedance of leg (left) 0.5 2.3 3.8 -1.9 -0.9
Leg predicted mass (left) 0.6 3.1 6.2 2.5 0.1
Trunk fat mass 0.3 1.3 1.5 1.0 -1.2
Waist circumference 0.3 1.0 1.5 1.2 -0.8
Number of incorrect matches in round 3.5 5.8 9.9 -1.3 -3.1
Past tobacco smoking 3.3 6.1 9.8 1.6 3.1
Alcohol usually taken with meals 0.1 0.2 0.3 -0.0 -0.6
Nervous feelings 0.8 1.4 2.0 -0.9 1.4
Frequency of tenseness / restlessness in last 2 weeks 0.8 1.3 2.4 0.4 1.5
Hearing difficulty/problems with background noise 0.1 0.1 0.2 0.4 -0.1
Hair/balding pattern: Pattern 2 3.2 4.1 7.7 0.7 2.8
Had menopause 1.2 1.6 2.6 -1.6 -0.7
Had other major operations 1.0 1.2 1.5 -1.0 -1.2
Forced vital capacity (FVC) 0.5 1.8 3.6 0.1 -1.9
Heel bone mineral density (BMD) T-score, automated (right) 0.0 0.0 0.0 0.0 -0.1
Ever unenthusiastic/disinterested for a whole week 0.6 0.8 1.0 -1.0 0.7
Qualifications: None of the above 5.1 10.9 13.0 -3.0 -3.6
Financial difficulties in last 2 years 0.2 0.3 0.4 0.7 -0.5
Mouth/teeth dental problems 0.1 0.1 0.3 -0.2 -0.5
Heart attack 5.0 6.5 6.5 -2.5 -2.5
Allergy 0.6 1.4 1.8 -1.0 -1.3
Pain all over the body in last month 0.2 0.2 0.4 0.7 -0.2
Diabetes (self-reported) 1.1 1.7 3.3 1.8 0.3
Hayfever/allergic rhinitis (self-reported) 0.0 0.1 0.1 -0.3 0.0
Medication: Ramipril 0.1 0.1 0.2 0.1 -0.5
Medication: Simvastatin 0.2 0.2 0.3 -0.5 -0.4
Fluid intelligence score 2.4 5.0 6.0 2.0 2.4
Illnesses of siblings 0.7 0.9 1.4 0.7 1.2
Neuroticism score 0.2 0.4 0.8 -0.2 0.9
Weight 0.5 2.3 3.7 1.9 -0.9
Impedance of arm (right) 0.3 1.2 2.3 -1.5 -0.3
Arm fat percentage (right) 0.1 0.4 0.5 0.6 -0.7
Trunk fat-free mass 0.6 3.3 6.1 2.5 0.7
Hip circumference 0.3 1.1 1.7 1.3 -0.7
Time employed in main current job 1.1 1.2 2.5 1.6 -0.0
Alcohol intake versus 10 years previously 5.0 7.4 8.0 -2.8 -2.6
Father’s age at death 0.4 0.5 0.6 -0.7 -0.7
Worrier / anxious feelings 0.6 1.1 2.2 -1.5 0.0
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.7 0.7 0.9 0.8
Falls in the last year 0.7 0.9 1.8 0.2 1.3
Hair/balding pattern: Pattern 3 0.1 0.2 0.2 0.5 -0.3
Number of live births 0.5 0.7 1.0 1.0 -0.6
Forced expiratory volume in 1-second (FEV1) 0.4 1.4 2.8 -0.1 -1.7
Pulse rate 1.3 2.2 4.3 2.1 0.4
Happiness 0.2 0.3 0.5 0.1 0.7
Noisy workplace 4.1 5.0 5.3 -2.2 -2.3
Qualifications: A levels/AS levels or equivalent 0.7 1.6 2.0 1.1 1.4
Serious illness, injury or assault of a close relative in last 2 years 1.1 1.2 2.0 1.4 0.7
Mouth/teeth dental problems: Dentures 0.5 0.8 1.5 0.4 1.2
Asthma 1.8 3.6 6.0 2.4 -1.2
Medication: Ibuprofen (e.g. Nurofen) 0.7 0.8 0.9 0.9 -0.9
Medication: Cholesterol lowering 0.5 0.8 1.4 -1.2 -0.4
Depression (self-reported) 0.3 0.4 0.6 -0.4 -0.7
Medication: Lansoprazole 0.2 0.2 0.5 -0.1 -0.7
Prospective memory result 0.2 0.2 0.3 0.5 0.3
Lung cancer (father) 1.3 1.5 2.6 -1.6 -0.7
Illnesses of mother 0.6 0.8 1.1 1.0 -0.7
Forced expiratory volume in 1-second (FEV1), Best measure 1.0 3.3 6.6 -0.2 -2.6
Pulse wave Arterial Stiffness index 0.3 0.4 0.6 0.4 0.8
Impedance of arm (left) 0.5 2.2 3.9 -2.0 -0.7
Arm fat mass (right) 0.3 1.4 2.5 1.6 -0.5
Trunk predicted mass 0.6 3.4 6.3 2.5 0.7
Standing height 0.1 1.1 2.0 1.4 -0.3
Length of working week for main job 1.4 1.6 2.8 1.7 0.7
Exposure to tobacco smoke at home 0.2 0.2 0.4 -0.1 0.6
Breastfed as a baby 0.8 1.0 1.3 -0.8 1.1
Tense / ‘highly strung’ 1.8 2.9 5.4 -2.3 -0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 1.7 2.5 3.5 -1.2 -1.9
Hair/balding pattern: Pattern 4 0.0 0.0 0.0 0.0 -0.1
Birth weight of first child 0.8 1.5 2.9 1.7 -0.4
Peak expiratory flow (PEF) 0.2 0.4 0.4 -0.6 -0.6
Pulse wave reflection index 0.2 0.2 0.2 -0.5 0.4
Ever highly irritable/argumentative for 2 days 0.1 0.1 0.3 0.1 0.5
Loud music exposure frequency 0.2 0.2 0.3 -0.4 -0.5
Qualifications: O levels/GCSEs or equivalent 3.1 4.9 8.2 1.3 2.9
Mouth/teeth dental problems: Bleeding gums 0.5 0.6 1.2 -1.1 0.3
Blood clot in the leg (DVT) 1.2 1.5 3.0 1.7 0.3
Medication: Paracetamol 0.0 0.0 0.0 -0.0 0.1
Headache pain in last month 1.1 1.8 2.5 1.6 -1.1
Medication for cholesterol, blood pressure or diabetes 0.3 0.5 0.7 -0.9 -0.6
Glaucoma (self-reported) 0.7 0.8 1.3 0.5 1.1
Gout (self-reported) 1.1 1.5 2.5 -1.6 0.6
Hypothyroidism/myxoedema (self-reported) 0.7 1.4 2.5 -0.5 1.6
Medication: Amlodipine 0.3 0.5 0.5 0.6 0.7
Medication: Ventolin 100micrograms inhaler 0.6 0.8 1.4 1.2 -0.5
Birth weight 0.3 0.7 1.0 1.0 -0.6
Chronic bronchitis/emphysema (mother) 0.1 0.2 0.2 0.3 -0.4
High blood pressure (siblings) 0.5 0.7 1.2 -1.1 -0.5
Forced vital capacity (FVC), Best measure 1.2 4.3 8.6 0.0 -2.9
Body fat percentage 0.3 1.2 2.2 0.3 -1.5
Leg fat percentage (right) 0.4 1.4 2.2 0.7 -1.5
Arm fat-free mass (right) 0.4 2.2 4.4 2.1 -0.2
Exposure to tobacco smoke outside home 0.5 0.6 1.3 1.1 0.1
Comparative body size at age 10 0.7 1.8 3.0 1.7 -0.8
Number of full brothers 0.6 0.8 0.9 -0.8 -0.9
Worry too long after embarrassment 0.9 1.5 1.6 -1.2 -1.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.3 0.4 -0.4 -0.7
Wheeze or whistling in the chest in last year 0.5 0.9 1.6 -0.4 -1.3
Number of children fathered 5.2 5.8 9.6 -1.4 -3.1
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.5 0.8 0.9 -0.3
Age at first live birth 0.7 1.2 2.0 1.4 0.7
Pulse wave peak to peak time 0.5 0.5 1.0 -0.3 -1.0
Health satisfaction 0.7 1.0 1.6 -0.6 -1.3
Shortness of breath walking on level ground 0.6 0.7 1.3 -0.3 -1.1
Qualifications: College or University degree 1.2 3.7 4.7 1.6 2.2
Eye problems/disorders: None of the above 0.4 0.5 0.8 -0.4 0.9
Mouth/teeth dental problems: Loose teeth 0.6 0.7 1.4 0.3 1.2
Emphysema/chronic bronchitis 1.7 1.9 2.6 -1.6 -1.1
Medication for pain relief, constipation, heartburn 2.3 3.9 5.4 1.5 2.3
Neck or shoulder pain in last month 0.0 0.1 0.1 -0.1 -0.3
Medication: Blood pressure 0.3 0.6 0.9 0.5 1.0
Angina (self-reported) 3.0 4.0 5.5 -1.6 -2.4
Migraine (self-reported) 0.4 0.6 1.1 1.1 -0.1
Medication: Ibuprofen 0.4 0.5 0.5 0.6 -0.7
Medication: Allopurinol 0.8 1.1 2.1 -1.4 0.2
Medication: Omeprazole 1.7 2.0 4.0 -0.1 -2.0
Medication: Seretide 50 evohaler 0.5 0.6 0.7 0.8 -0.7
Mean time to correctly identify matches 1.2 2.3 3.2 -1.8 -1.1
Heart disease (mother) 0.1 0.1 0.3 -0.5 -0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.6 0.8 0.9 0.7
Whole body fat mass 0.3 1.4 1.6 1.1 -1.2
Leg fat mass (right) 0.4 1.7 1.9 1.4 -1.2
Arm predicted mass (right) 0.5 2.6 5.3 2.3 0.0
Pulse rate, automated reading 0.8 2.6 4.1 2.0 1.0
Alcohol intake frequency. 0.1 0.3 0.6 -0.8 0.1
Comparative height size at age 10 0.6 3.3 5.3 -1.1 -2.3
Number of full sisters 2.3 2.8 5.1 -0.7 -2.3
Suffer from ‘nerves’ 0.7 1.1 2.0 -1.4 0.5
Overall health rating 0.1 0.3 0.3 -0.6 -0.6
Chest pain or discomfort 1.6 2.4 2.5 -1.6 -1.5
Had major operations 0.8 0.9 1.7 -1.3 -0.4
Age at last live birth 0.0 0.1 0.1 0.3 -0.2
Family relationship satisfaction 0.2 0.3 0.4 0.6 0.5
Leg pain on walking 0.3 0.4 0.5 0.5 0.7
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 0.9 -0.0 -1.0
Commuting to job workplace: Car/motor vehicle 2.7 3.1 3.7 -1.9 -1.6
Illness, injury, bereavement, stress in last 2 years 1.0 1.2 1.2 -1.1 -1.1
Medication: Aspirin 4.5 5.9 9.2 -3.0 -1.6
Supplements: Vitamin C 0.7 0.9 1.8 0.0 -1.3
Knee pain experienced in last month 0.3 0.4 0.7 -0.8 0.4
Hypertension (Self-reported) 0.1 0.2 0.2 -0.5 0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.5 1.7 3.5 -0.0 -1.9
Illnesses of father: Heart disease 0.1 0.1 0.2 0.4 0.1
Illnesses of siblings: Diabetes 3.4 4.1 8.2 -0.3 -2.9
Smoking status: Previous 4.4 6.6 10.0 -1.8 -3.2
Forced expiratory volume in 1-second (FEV1), predicted 1.8 3.8 4.2 2.0 1.8
Whole body fat-free mass 0.6 3.4 6.7 2.6 0.4
Leg fat-free mass (right) 0.6 3.0 5.9 2.4 0.1
Arm fat percentage (left) 0.1 0.5 0.8 0.5 -0.9
Average weekly red wine intake 1.3 1.9 3.1 1.8 0.9
Handedness (chirality/laterality): Left-handed 0.3 0.4 0.5 0.7 -0.5
Mood swings 0.2 0.4 0.4 -0.6 0.6
Loneliness, isolation 0.2 0.2 0.3 0.4 0.6
Long-standing illness, disability or infirmity 3.6 5.4 8.2 -1.6 -2.9
Ever had bowel cancer screening 3.2 3.7 7.4 -0.1 -2.7
Diabetes diagnosed by doctor 0.9 1.4 2.8 1.7 -0.1
Ever had stillbirth, spontaneous miscarriage or termination 1.1 1.2 1.9 0.6 -1.4
Friendships satisfaction 2.6 3.2 4.2 2.0 1.5
Qualifications: nursing, teaching 0.2 0.3 0.3 0.5 -0.5
Commuting to job workplace: Walk 0.4 0.4 0.5 0.5 0.7
Eye problems/disorders: Cataract 1.8 2.1 3.5 0.9 -1.9
Mouth/teeth dental problems: Mouth ulcers 0.1 0.2 0.3 -0.4 -0.5
Medication for cholesterol 1.1 1.6 1.7 1.3 1.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.5 0.6 -0.6 -0.8
Back pain experienced in last month 0.5 0.7 1.1 -0.6 -1.1
Mineral and other dietary supplements 0.8 1.1 1.8 0.6 -1.3
Breast cancer (self-reported) 0.2 0.2 0.4 0.1 0.7
Asthma (self-reported) 1.8 3.7 5.3 2.3 -1.4
Osteoporosis (self-reported) 2.2 2.7 4.5 -0.9 -2.1
Osteoarthritis (self-reported) 1.0 1.3 2.6 -1.6 0.3
Medication: Aspirin 3.7 4.8 7.4 -2.7 -1.5
Medication: Gliclazide 0.7 0.8 1.5 1.2 0.4
Illnesses of father: None of the above (group 1) 1.0 1.3 2.4 -1.5 0.4
Smoking status: Current 0.2 0.3 0.3 0.5 -0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.1 2.2 3.9 -0.7 -2.0
Whole body water mass 0.7 3.8 7.2 2.7 0.5
Leg predicted mass (right) 0.6 3.0 5.9 2.4 0.2
Arm fat mass (left) 0.3 1.1 1.8 1.3 -0.6
Number of self-reported non-cancer illnesses 0.4 0.6 0.9 -1.0 -0.5
Average weekly champagne plus white wine intake 0.5 0.6 1.1 1.1 0.3
Miserableness 1.3 2.2 4.1 0.6 2.0
Guilty feelings 0.7 1.1 1.3 -1.2 -0.9
Wears glasses or contact lenses 0.8 0.9 1.7 1.3 0.2
Ever taken oral contraceptive pill 0.2 0.3 0.3 0.5 0.6
Hearing aid user 2.4 2.7 5.3 -0.4 -2.3
Mother’s age at death 2.0 2.5 3.5 1.2 1.9
Financial situation satisfaction 1.5 1.9 2.7 -1.1 -1.6
Tinnitus: Yes, now most or all of the time 2.8 3.3 5.7 -0.9 -2.4
Commuting to job workplace: Public transport 2.3 2.8 3.6 1.4 1.9
Eye problems/disorders: Glaucoma 0.2 0.2 0.3 -0.4 0.6
Medication: Blood pressure 0.7 1.4 2.8 -1.7 -0.2
Pain type(s) experienced in last month: Hip pain 0.0 0.1 0.1 -0.1 -0.3
Supplements: Fish oil (including cod liver oil) 0.2 0.2 0.5 -0.2 0.7
High cholesterol (Self-reported) 0.0 0.1 0.1 -0.1 -0.4
Medication: Bendroflumethiazide 0.7 1.1 1.8 -1.3 0.6
Medication: Paracetamol 0.0 0.0 0.1 0.3 -0.0
Medication: Lisinopril 0.4 0.5 0.5 0.7 0.7
Medication: Atorvastatin 0.2 0.2 0.3 -0.4 0.5
Illnesses of father: High blood pressure 0.1 0.1 0.2 -0.4 -0.3
Alcohol drinker status: Never 0.1 0.2 0.3 -0.2 -0.5
Ever smoked 1.4 2.4 3.8 -1.0 -1.9
Basal metabolic rate 0.6 3.4 6.7 2.6 0.2
Leg fat percentage (left) 0.4 1.4 2.2 0.7 -1.5
Arm fat-free mass (left) 0.4 2.2 4.4 2.1 0.1
Number of operations (self-reported) 1.9 2.8 4.1 -2.0 -1.2
Average weekly beer plus cider intake 0.5 0.8 1.5 -0.1 -1.2
Irritability 0.1 0.2 0.3 -0.6 -0.3
Risk taking 3.5 5.2 7.2 -1.8 -2.7
Ever had prostate specific antigen (PSA) test 0.7 0.8 1.4 0.5 1.2
Fractured/broken bones in last 5 years 0.0 0.0 0.0 0.1 -0.2
Age started oral contraceptive pill 0.1 0.1 0.3 0.5 -0.1
Diastolic blood pressure, automated reading 0.6 1.8 3.3 -1.8 -0.6
Ever depressed for a whole week 0.7 0.8 1.5 0.4 1.2
Unable to work because of sickness or disability 0.7 0.9 1.7 -0.2 -1.3
Commuting to job workplace: Cycle 1.1 1.4 2.3 1.5 0.6
Myopia 0.0 0.1 0.1 0.3 0.2
Vascular/heart problems diagnosed by doctor 0.4 1.1 2.2 1.5 0.0
Cholesterol lowering medication 0.5 0.7 0.7 -0.8 -0.8
Medication: Omeprazole (e.g. Zanprol) 0.9 1.1 1.9 -0.6 -1.4
Pain experienced in last month 0.2 0.3 0.4 -0.6 0.5
Supplements: Calcium 0.7 0.7 0.8 -0.9 0.8
Basal cell carcinoma (self-reported) 0.1 0.1 0.1 0.4 0.1
Heart attack/myocardial infarction (self-reported) 4.2 5.4 5.7 -2.4 -2.3
Deep venous thrombosis (DVT) (self-reported) 1.0 1.3 2.4 1.5 0.5
Heart disease (siblings) 0.4 0.5 0.5 -0.7 -0.7
Alcohol drinker status: Previous 0.7 0.8 1.4 0.5 1.2
Pack years of smoking 0.1 0.2 0.3 -0.4 -0.6
Impedance of whole body 0.6 3.0 5.0 -2.2 -1.0
Leg fat mass (left) 0.4 1.6 2.0 1.4 -1.1
Arm predicted mass (left) 0.5 2.5 4.9 2.2 -0.2