TWAS hub - MLEC

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Hippocampus	0.2822	0.1188	8.4e-03	0.032	NA	0.085	NA	0.066	6.2e-02	NA	5.1e-03	NA	1.2e-02
2	GTEx	Ovary	0.4160	0.1110	1.4e-03	-0.006	NA	0.097	NA	0.026	4.8e-01	NA	2.2e-03	NA	7.8e-02
3	GTEx	Skin Sun Exposed Lower leg	0.1170	0.0380	2.0e-05	0.098	NA	0.107	NA	0.118	1.7e-08	NA	3.4e-09	NA	5.4e-10
4	YFS	Blood	0.0665	0.0162	1.6e-12	0.011	0.048	0.042	0.048	0.036	1.0e-04	1.6e-15	1.2e-13	1.5e-15	5.3e-12
5	TCGA	Pheochromocytoma and Paraganglioma	0.2630	0.1070	5.1e-03	0.084	-0.005	0.056	NA	0.086	3.1e-04	6.0e-01	2.9e-03	NA	2.6e-04
6	TCGA	Prostate Adenocarcinoma	0.0503	0.0296	1.9e-03	0.046	0.029	0.032	NA	0.045	1.4e-05	4.3e-04	2.3e-04	NA	1.7e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Blood Red Count	11.8	114.0	233.0	-0.8	6.7	-15.3	-12.5	7.1	14.1
LDL Cholesterol	4.4	6.9	16.6	2.2	4.1	-3.9	-1.7	-1.3	-0.2
Noisy workplace	4.3	5.3	10.3	-0.3	2.8	-1.8	-3.2	-0.2	3.2
Mean Putamen Volume	4.2	4.8	9.4	0.2	-2.7	1.8	3.1	-1.2	-2.7
Emphysema/chronic bronchitis	3.9	4.4	9.4	0.0	3.1	-2.2	-2.6	0.3	2.4
Lung FVC	3.4	17.5	43.0	-1.7	3.0	-6.4	-2.9	0.7	6.6
Severe depression (siblings)	3.3	3.6	8.0	-0.1	-0.7	1.3	2.6	-2.8	-2.2
Allergy or Eczema	3.1	8.1	24.8	-1.0	-2.9	5.0	-2.4	1.8	-2.3
Ever used hormone-replacement therapy (HRT)	3.1	3.9	12.9	-1.5	0.5	-1.9	-3.6	0.9	1.9
Illnesses of siblings	3.0	4.2	9.8	2.5	-1.5	2.1	-1.5	3.1	-0.2
Alcohol intake versus 10 years previously	2.9	4.3	10.0	-1.1	2.8	-3.2	-0.1	-2.1	1.5
Maternal smoking around birth	2.8	4.0	10.7	-3.3	-0.3	-0.8	-1.9	-2.8	-1.1
Heart attack	2.7	3.5	7.3	-1.6	2.2	-2.7	-1.2	-1.3	1.6
Hayfever, allergic rhinitis or eczema	2.6	5.6	15.6	-0.3	-2.9	4.0	-2.1	1.6	-1.6
Osteoarthritis (self-reported)	2.6	3.4	7.7	-1.5	1.9	-2.8	-1.3	-0.1	2.3
High cholesterol (Self-reported)	2.6	4.6	16.3	1.4	2.6	-4.0	0.0	-1.6	0.3
Coronary Artery Disease (CAD)	2.5	3.0	13.4	0.4	1.2	-3.7	-1.0	-0.9	1.2
Relative age voice broke	2.5	3.7	10.8	-0.1	-0.6	3.2	-0.8	3.3	0.6
Allergy	2.5	5.7	23.1	1.0	1.2	-4.8	1.8	-1.1	2.0
Medication: Cholesterol lowering	2.5	3.9	15.7	0.8	4.0	-2.4	0.4	-1.0	0.3
Qualifications: O levels/GCSEs or equivalent	2.5	4.0	8.9	3.0	-2.1	0.8	2.6	0.1	-1.7
Age started oral contraceptive pill	2.5	3.1	16.3	-4.0	-0.5	0.7	-1.0	-0.2	0.8
Commuting to job workplace: Car/motor vehicle	2.4	2.8	5.0	-0.8	2.1	-1.7	-1.9	0.5	2.2
Frequency of unenthusiasm / disinterest in last 2 weeks	2.3	3.1	9.1	-3.0	-1.4	1.7	1.3	-1.4	-1.1
Asthma	2.3	4.5	14.2	-2.3	0.4	3.8	-0.5	-1.1	-2.5
Ovarian Cancer	2.2	2.9	9.6	-0.9	1.3	-3.1	-1.9	-1.1	0.7
Hypothyroidism (self reported)	2.2	4.9	13.9	-3.7	-1.1	3.7	0.2	0.3	-0.9
Diabetes (father)	2.2	2.7	6.4	-1.7	-1.4	1.8	0.5	-1.1	-2.5
Blood clot in the leg (DVT)	2.2	2.9	11.1	-1.9	1.0	0.9	0.8	-3.3	-0.1
Illness, injury, bereavement, stress in last 2 years	2.2	2.7	6.6	-2.6	-2.3	-0.0	-1.7	0.5	1.0
Medication: Aspirin	2.2	2.8	7.7	-0.3	2.0	-2.8	-2.0	-0.4	1.1
Past tobacco smoking	2.1	3.9	9.0	-0.4	-2.3	1.3	2.4	1.2	-3.0
Gout (self-reported)	2.1	2.9	5.7	1.6	1.5	-2.4	-0.5	1.1	2.3
Number of children fathered	2.1	2.3	8.1	-2.8	-1.1	-0.8	-1.1	-0.8	1.5
Smoking status: Previous	2.1	3.1	7.5	1.0	1.3	-1.5	-2.3	-1.0	2.7
Commuting to job workplace: Public transport	2.1	2.6	7.4	0.1	-0.9	1.9	1.8	-0.5	-2.7
Cholesterol lowering medication	2.1	3.1	12.2	0.5	0.7	-3.5	-2.3	0.1	0.3
Heart attack/myocardial infarction (self-reported)	2.1	2.7	5.9	-1.6	2.0	-2.4	-1.1	-1.3	1.0
Deep venous thrombosis (DVT) (self-reported)	2.1	2.7	11.1	-1.6	1.1	0.8	1.0	-3.3	-0.1
Medication: Ventolin 100micrograms inhaler	2.0	2.5	3.7	-1.6	1.9	1.8	-0.6	-1.4	-1.9
Loneliness, isolation	2.0	2.8	9.7	-3.1	1.3	1.0	0.4	-2.0	0.6
Back pain experienced in last month	2.0	2.9	6.5	0.7	2.1	-2.5	0.1	-1.6	1.8
Asthma (self-reported)	2.0	3.9	12.7	-1.9	0.7	3.6	-0.8	-0.8	-2.3
Bipolar Disorder or Schizophrenia	1.9	4.6	13.8	1.6	3.7	-1.7	0.1	-1.5	2.4
Age at First Birth	1.9	2.8	7.5	-0.7	-0.7	2.7	1.7	-1.2	-2.0
Had menopause	1.9	2.4	6.4	-2.5	2.0	-0.3	-1.7	-0.9	0.4
Medication: Aspirin	1.9	2.4	5.9	-0.6	1.6	-2.4	-2.1	-0.5	1.0
Diabetes (mother)	1.8	2.3	8.0	2.8	0.7	-1.4	-1.5	0.7	0.8
Medication: Simvastatin	1.8	2.6	9.8	1.2	3.1	-2.0	0.1	-0.6	0.3
Loud music exposure frequency	1.8	2.0	3.9	1.7	1.6	-2.0	-0.4	1.6	0.2
Reason for reducing amount of alcohol drunk: Health precaution	1.8	2.1	7.1	0.0	0.1	1.7	1.4	-2.7	-0.7
Age at first live birth	1.8	3.2	6.2	0.9	-1.6	2.5	2.4	-0.5	-1.8
Mean time to correctly identify matches	1.8	3.3	8.2	-0.8	2.9	-1.5	-1.7	0.2	2.4
Bipolar Disorder (2018)	1.7	2.7	9.8	2.2	3.1	-0.3	0.5	-0.8	0.8
Intelligence (Savage-Jansen 2018)	1.7	5.2	16.1	2.8	0.2	4.0	1.8	1.0	-1.9
Schizophrenia vs Biploar Disorder	1.7	2.2	6.9	-2.6	-1.0	-1.5	-1.7	-0.5	0.4
Relative age of first facial hair	1.7	3.4	11.3	-0.8	0.1	3.4	-0.5	2.8	-0.7
Qualifications: None of the above	1.7	3.6	6.5	-2.5	0.7	-2.5	-2.5	-0.4	1.5
Lung cancer (father)	1.7	2.0	5.5	-1.4	1.4	-2.4	-1.0	-0.9	0.7
Illnesses of mother	1.7	2.1	6.1	-1.6	-2.5	0.6	0.2	-1.5	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.7	2.3	6.7	-1.2	2.6	0.2	1.4	-1.8	-0.3
Qualifications: College or University degree	1.7	5.3	15.8	4.0	-1.4	2.5	1.8	1.2	-1.7
Medication for pain relief, constipation, heartburn	1.7	2.9	6.2	0.3	-0.8	2.4	2.1	-0.4	-2.5
Osteoporosis (self-reported)	1.7	2.1	4.5	-1.5	1.2	-2.1	-0.9	-1.1	1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.7	3.6	8.8	-1.6	1.0	-2.9	-0.6	-0.7	3.0
Smoking Status	1.6	3.8	7.4	-0.5	2.0	-0.8	-1.9	-2.7	2.6
Number of incorrect matches in round	1.6	2.7	5.5	-2.1	0.6	-1.7	-1.7	-0.1	2.3
Ever unenthusiastic/disinterested for a whole week	1.6	2.0	6.4	1.8	2.5	0.3	0.4	0.6	1.3
Serious illness, injury or assault of a close relative in last 2 years	1.6	1.8	5.9	2.4	0.8	0.6	1.9	-0.5	-0.5
Depression (self-reported)	1.6	1.9	6.2	-1.2	1.7	-0.5	0.0	-0.7	2.5
Number of full brothers	1.6	2.1	4.4	-2.1	-1.8	-1.5	-0.3	0.0	1.5
Neck or shoulder pain in last month	1.6	2.2	7.5	1.4	2.7	-1.5	-0.6	-0.8	0.9
Friendships satisfaction	1.6	2.0	6.6	-0.8	0.5	1.7	2.6	1.0	-0.9
Depression (Nagel 2018)	1.5	2.2	6.1	-2.5	-0.4	0.9	0.9	-2.2	-0.7
Medication for cholesterol, blood pressure or diabetes	1.5	2.4	4.6	-0.9	-2.1	0.7	-1.8	1.6	1.6
Number of operations (self-reported)	1.5	2.3	5.7	0.2	1.9	-1.9	0.0	-0.6	2.4
Fractured/broken bones in last 5 years	1.5	1.9	6.3	2.5	-0.1	1.0	0.7	1.9	-0.3
Ever depressed for a whole week	1.5	1.8	6.2	2.5	1.1	0.7	0.2	1.6	0.6
HDL Cholesterol	1.4	2.3	4.8	2.1	1.3	-2.2	-0.5	1.1	1.2
Neuroticism	1.4	3.4	18.2	-4.3	-0.9	0.9	-0.1	-0.5	0.3
Other serious medical condition/disability diagnosed by doctor	1.4	1.8	3.7	1.1	1.9	-0.1	-0.9	1.8	1.4
Eye problems/disorders: Diabetes related eye disease	1.4	1.6	5.5	0.7	2.3	0.5	0.1	-1.0	-1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.4	2.2	6.5	-0.9	2.5	-0.7	0.5	-1.5	1.7
Hypothyroidism/myxoedema (self-reported)	1.4	2.7	8.0	-2.5	-0.9	2.8	-0.1	0.8	-0.8
Wheeze or whistling in the chest in last year	1.4	2.5	9.5	-0.1	3.1	1.3	-1.7	-0.3	1.0
Pulse wave peak to peak time	1.4	1.6	2.7	-1.3	-1.6	-0.7	1.6	-0.9	1.0
Supplements: Vitamin C	1.4	1.6	6.6	-2.6	0.6	-0.5	-0.4	-1.2	0.8
Illnesses of siblings: Diabetes	1.4	1.7	4.3	-1.1	0.4	-2.0	0.1	-2.1	-0.5
Ever had bowel cancer screening	1.4	1.6	3.9	-1.6	1.0	-0.1	-1.4	-2.0	-0.3
Blood Eosinophil Count	1.3	10.3	25.6	-3.2	-3.5	5.1	-0.2	-1.2	-3.5
Sensitivity / hurt feelings	1.3	2.2	11.8	-3.4	-0.1	0.7	0.9	-0.1	0.2
Angina	1.3	1.8	5.9	0.1	1.8	-2.4	-0.4	-1.1	0.1
Age when periods started (menarche)	1.3	3.1	13.9	-0.4	-0.3	3.7	0.8	2.0	-0.5
Nervous feelings	1.3	2.3	7.3	-0.1	-1.5	2.7	0.2	1.4	-1.6
Fluid intelligence score	1.3	2.6	6.8	1.2	-1.2	2.6	1.8	0.0	-1.8
Breastfed as a baby	1.3	1.6	8.7	2.9	0.6	-0.1	0.1	0.2	-0.9
Chronic bronchitis/emphysema (mother)	1.3	1.5	4.4	-1.9	2.1	0.1	0.3	-0.9	0.5
Angina (self-reported)	1.3	1.7	5.7	0.1	1.7	-2.4	-0.6	-1.0	0.2
Chest pain or discomfort	1.3	1.9	5.6	-0.5	2.4	-1.0	-0.8	-1.3	1.5
Long-standing illness, disability or infirmity	1.3	2.0	5.2	0.1	2.2	-0.9	-2.3	0.7	1.1
Tinnitus: Yes, now most or all of the time	1.3	1.6	3.4	-0.8	-0.6	-1.0	-1.0	-1.7	-1.8
Commuting to job workplace: Cycle	1.3	1.6	4.0	2.0	-0.2	1.5	0.6	1.7	-0.2
Schizophrenia (2018)	1.2	2.6	5.8	0.3	2.0	-1.9	-0.2	-1.3	2.4
Rheumatoid Arthritis	1.2	1.6	6.4	-2.5	-1.2	-0.2	-0.6	-1.2	-0.5
Blood Platelet Count	1.2	14.1	47.1	-1.4	-3.7	6.9	2.4	3.9	-0.8
Pack years adult smoking proportion	1.2	1.8	9.0	-0.1	3.0	-0.9	-0.5	-0.7	-0.6
Trunk fat percentage	1.2	4.9	14.6	-3.0	1.4	-0.9	-3.8	-1.2	1.1
Happiness	1.2	1.5	4.7	0.4	-0.1	1.4	1.2	0.9	-2.2
Qualifications: A levels/AS levels or equivalent	1.2	2.7	5.6	2.1	-1.1	1.6	2.4	0.8	-1.5
Pulse wave Arterial Stiffness index	1.2	1.4	2.4	1.1	1.5	0.8	-1.5	0.8	-1.2
Length of working week for main job	1.2	1.4	3.6	0.5	-1.0	1.5	0.5	1.9	-0.8
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.4	6.8	-2.6	-0.6	-0.3	-0.2	-1.0	0.4
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.5	4.5	-0.1	-2.1	1.7	2.1	-0.6	-1.7
Pack years of smoking	1.2	1.8	9.3	-0.1	3.0	-0.8	-0.6	-0.5	-0.5
Alzheimer’s Disease (in mother)	1.1	1.2	3.7	0.5	-0.6	0.4	-1.2	1.9	1.1
Ulcerative Colitis (UC)	1.1	2.0	4.8	2.2	-0.8	-1.8	1.3	-0.7	-1.2
Verbal and Numeric Reasoning (VNR)	1.1	2.5	8.2	1.5	-0.4	2.9	1.5	-0.7	-1.4
Respiratory disease	1.1	2.4	8.9	-0.6	0.3	3.0	-0.8	-0.4	-2.0
Supplements: Glucosamine	1.1	1.4	2.6	0.9	1.0	0.1	-1.3	1.6	1.5
Diabetes (self-reported)	1.1	1.7	4.2	1.3	1.0	0.9	1.4	-0.3	-2.1
Forced expiratory volume in 1-second (FEV1), Best measure	1.1	3.4	7.1	-2.5	-1.0	-2.4	0.2	0.2	2.7
Mouth/teeth dental problems: Bleeding gums	1.1	1.4	4.3	0.2	1.8	-2.1	-0.7	0.8	0.0
Body fat percentage	1.1	4.3	14.8	-2.5	1.2	-1.0	-3.8	-0.8	1.2
Worry too long after embarrassment	1.1	1.8	8.5	-1.5	-2.9	-0.1	0.3	0.2	-0.5
Medication: Blood pressure	1.1	2.0	4.0	1.2	2.0	-0.3	1.7	-1.2	-1.5
Arm fat percentage (left)	1.1	4.2	15.2	-2.0	1.9	-0.7	-3.9	-0.4	1.2
Diabetes diagnosed by doctor	1.1	1.8	4.9	1.4	1.2	0.6	1.2	-0.7	-2.2
Medication: Atorvastatin	1.1	1.3	3.9	-1.1	2.0	-1.2	0.2	-1.2	-0.4
Ever smoked	1.1	1.9	6.4	0.5	1.4	-0.5	-1.6	-0.3	2.5
Myopia	1.1	1.6	4.4	0.5	-1.6	1.3	-0.6	-0.8	-2.1
Basal cell carcinoma (self-reported)	1.1	1.3	3.7	-1.9	0.4	0.6	0.0	-1.9	0.5
Depressed Affect (Nagel 2018)	1.0	2.1	11.2	-3.3	-0.3	0.4	0.5	-0.9	0.3
Crohns Disease (2012)	1.0	1.6	4.0	-1.9	0.6	-0.5	0.0	-1.3	2.0
Neuroticism (2016)	1.0	1.5	4.6	-1.0	0.5	-1.3	-2.1	-0.3	1.0
Schizophrenia (2014)	1.0	2.3	5.2	0.1	1.3	-2.2	-1.4	-0.3	2.3
Chronotype (morning person)	1.0	2.3	5.6	1.7	-1.9	0.3	1.2	2.4	0.0
Medication: Co-codamol	1.0	1.2	2.0	-1.4	1.2	-1.2	-1.0	-0.8	0.8
Taking other prescription medications	1.0	1.5	3.6	-1.2	1.9	0.5	-1.7	-0.7	0.5
Forced expiratory volume in 1-second (FEV1)	1.0	3.3	6.7	-2.6	-1.3	-2.2	0.3	-0.0	2.6
High blood pressure (siblings)	1.0	1.5	3.5	-1.9	0.2	-1.5	-0.1	-1.7	0.3
Forced vital capacity (FVC), Best measure	1.0	3.8	9.0	-2.3	-0.4	-2.8	0.4	-0.4	3.0
Medication: Allopurinol	1.0	1.3	4.4	0.6	0.9	-2.1	-0.7	0.7	1.2
Family relationship satisfaction	1.0	1.3	3.5	-0.3	-0.0	1.4	0.5	1.3	-1.9
Mineral and other dietary supplements	1.0	1.4	3.0	-0.6	-0.9	0.1	1.2	-1.7	-1.6
Ever taken oral contraceptive pill	1.0	1.1	4.3	2.1	0.4	-0.4	1.0	0.8	-0.6
Hearing aid user	1.0	1.1	2.2	-1.2	1.5	-0.9	0.1	-0.3	1.5
Mother’s age at death	1.0	1.2	3.1	1.1	1.8	1.6	0.5	0.3	0.3
Leg fat percentage (left)	1.0	3.4	12.3	-1.9	1.2	-1.0	-3.5	-0.4	1.4
Neuroticism (Nagel 2018)	0.9	2.2	11.4	-3.4	-1.1	-0.1	-0.2	-0.7	0.3
Major Depression (MDD)	0.9	1.1	1.9	1.3	0.9	1.4	0.9	1.1	0.5
Bipolar Disorder (2011)	0.9	0.9	2.0	0.7	1.4	1.0	1.3	-0.0	0.4
Fasting Glucose	0.9	1.0	3.3	0.4	1.8	0.5	1.5	-0.5	0.1
Lupus	0.9	1.3	4.1	1.4	-0.6	0.8	2.0	-0.1	-0.9
Primary Biliary Cirrhosis	0.9	1.2	4.7	2.2	-0.4	-1.2	-0.6	0.2	0.9
Hearing difficulty/problems: Yes	0.9	1.4	3.2	-1.0	1.8	0.6	0.7	-1.3	-1.3
Supplements: Zinc	0.9	0.9	4.1	0.6	0.3	-0.7	-0.5	0.5	2.0
Serious illness, injury or assault to yourself	0.9	1.1	4.5	2.1	1.2	-0.6	0.1	-0.0	-0.2
Stomach or abdominal pain in last month	0.9	1.1	2.1	-1.2	0.9	-0.6	-0.9	-1.4	1.0
Trunk fat mass	0.9	3.7	10.2	-3.2	1.1	-0.5	-3.0	-1.4	0.4
Hair/balding pattern: Pattern 2	0.9	1.2	3.1	0.4	-0.5	1.8	0.4	1.5	1.0
Forced vital capacity (FVC)	0.9	3.5	8.5	-2.5	-0.6	-2.3	0.6	-0.4	2.9
Financial difficulties in last 2 years	0.9	1.3	4.2	-0.4	1.3	0.3	0.6	-2.0	-1.0
Arm fat percentage (right)	0.9	3.5	12.8	-2.4	1.2	-0.1	-3.6	-0.5	0.8
Falls in the last year	0.9	1.2	3.4	1.2	1.2	0.5	-0.4	1.9	-0.5
Hair/balding pattern: Pattern 4	0.9	2.1	8.0	-0.2	2.8	-1.4	-0.7	-1.0	1.0
Ever highly irritable/argumentative for 2 days	0.9	1.1	5.0	1.0	2.2	0.1	0.5	-0.0	-0.7
Knee pain experienced in last month	0.9	1.4	5.8	-0.6	0.6	-1.0	-2.4	-0.1	0.8
Risk taking	0.9	1.3	3.1	-0.9	1.7	-0.7	-0.3	-1.7	-0.5
Supplements: Calcium	0.9	1.0	5.1	0.3	2.3	0.6	-0.5	-0.4	0.2
Ulcerative Colitis	0.8	1.2	3.8	1.3	-0.0	-1.9	1.2	-0.4	-0.4
Height	0.8	15.5	51.8	-7.2	-3.1	-0.4	0.5	-4.8	-2.9
Type 2 Diabetes (T2D) (2018)	0.8	1.5	3.9	2.0	0.5	0.1	0.9	-0.6	-1.9
Body mass index (BMI)	0.8	3.3	9.6	-1.4	2.4	-0.8	-3.1	-0.1	1.4
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.3	2.7	-1.5	-0.7	0.3	1.6	-0.9	-1.2
Number of live births	0.8	1.1	2.9	-0.3	-0.5	1.0	-1.0	-1.1	-1.7
Pulse rate	0.8	1.3	6.0	-0.2	0.6	0.9	0.2	0.8	-2.5
Mouth/teeth dental problems: Dentures	0.8	1.3	4.2	2.0	1.0	1.3	-0.1	0.7	-0.6
Standing height	0.8	7.6	16.4	-4.0	-3.0	1.3	1.9	-2.6	-2.7
Tense / ‘highly strung’	0.8	1.4	6.6	-2.6	0.7	-0.1	-0.2	-0.2	1.1
Leg fat percentage (right)	0.8	2.8	9.1	-1.9	1.1	-0.9	-3.0	-0.7	1.3
Medication: Seretide 50 evohaler	0.8	0.9	2.4	-1.6	0.7	-0.3	-1.2	0.7	0.7
Whole body fat mass	0.8	3.5	9.2	-3.0	1.0	-0.6	-3.0	-1.2	0.3
Comparative height size at age 10	0.8	4.3	13.1	-1.9	-0.6	-2.8	0.6	-3.6	-0.7
Number of full sisters	0.8	1.0	2.1	-1.1	1.2	-0.7	-0.0	-1.4	0.8
Qualifications: nursing, teaching	0.8	1.2	3.1	0.9	0.0	-1.1	1.0	-0.9	1.8
Medication for cholesterol	0.8	1.2	2.2	1.5	1.1	0.6	1.4	-0.0	1.1
Medication: Gliclazide	0.8	0.9	1.6	1.3	0.5	1.2	0.8	0.6	-0.9
Number of self-reported non-cancer illnesses	0.8	1.4	5.2	-0.5	2.3	-0.2	-1.2	0.6	1.0
Supplements: Fish oil (including cod liver oil)	0.8	1.0	2.7	-0.6	0.2	-0.1	-1.6	1.4	1.0
Medication: Paracetamol	0.8	1.2	3.4	0.1	-0.8	-1.3	-0.6	1.1	1.8
Ever had prostate specific antigen (PSA) test	0.8	0.9	2.8	1.7	-0.6	0.4	-0.2	0.4	-1.3
Unable to work because of sickness or disability	0.8	1.1	4.0	0.6	2.0	-1.2	0.6	-0.1	0.5
Alzheimer’s Disease (including proxy)	0.7	1.0	2.3	0.1	0.2	0.7	-1.5	1.5	0.8
Type 2 Diabetes (T2D) (2012)	0.7	0.8	2.6	0.7	-0.1	-1.6	-0.9	-0.8	-0.3
Medication for hormone replacement therapy	0.7	0.8	1.9	-1.4	-0.5	-0.6	-1.3	-0.5	-0.3
High blood pressure (mother)	0.7	1.0	3.1	1.8	0.6	-0.4	1.1	1.2	0.1
Waist circumference	0.7	2.5	7.2	-2.3	1.2	0.3	-2.7	-0.7	-0.4
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	4.0	-0.0	0.7	1.1	2.0	-0.4	-1.0
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	2.5	-1.6	-0.5	1.1	-0.9	0.7	-0.1
Neuroticism score	0.7	1.4	6.4	-2.5	-0.9	0.8	0.3	-0.7	0.0
Prospective memory result	0.7	0.9	2.8	-0.6	-1.7	0.1	-0.0	-0.6	-1.3
Arm fat mass (right)	0.7	2.8	7.9	-2.7	1.1	0.2	-2.8	-0.8	0.2
Birth weight of first child	0.7	1.3	4.1	-1.3	-1.0	0.4	0.9	-2.0	0.4
Peak expiratory flow (PEF)	0.7	1.5	3.9	-1.2	-2.0	-1.0	-0.2	0.9	1.5
Health satisfaction	0.7	0.9	4.4	-0.2	0.6	0.4	-0.1	-0.6	-2.1
Eye problems/disorders: None of the above	0.7	0.8	2.0	1.4	-0.7	0.4	0.3	0.3	1.3
Alcohol intake frequency.	0.7	1.6	3.4	-1.6	1.8	-1.5	0.7	-0.5	0.6
Had major operations	0.7	0.8	3.1	0.1	-0.1	-0.8	1.8	-1.0	0.2
Handedness (chirality/laterality): Left-handed	0.7	0.9	1.6	-0.1	-1.1	0.7	1.3	-1.2	-0.7
Arm fat mass (left)	0.7	3.1	8.9	-2.6	1.5	-0.1	-3.0	-0.7	0.5
Average weekly champagne plus white wine intake	0.7	1.0	2.6	1.2	-0.1	1.2	0.2	1.6	-0.4
Pain type(s) experienced in last month: Hip pain	0.7	0.9	1.3	-1.0	0.9	-0.9	-1.1	-1.0	0.8
Medication: Bendroflumethiazide	0.7	1.1	2.5	1.4	0.5	-1.6	0.3	1.3	-0.2
Vascular/heart problems diagnosed by doctor	0.7	1.8	7.0	-1.1	-2.6	1.5	-0.4	0.5	0.4
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	2.4	0.3	-0.1	-0.9	-1.6	0.3	1.3
Worry (Nagel 2018)	0.6	1.2	4.8	-2.2	-1.2	0.6	0.0	-0.2	-0.6
Alzheimer’s Disease (in father)	0.6	0.6	2.7	-1.6	0.5	0.1	-0.8	-0.5	0.0
Blood White Count	0.6	4.6	10.0	-2.2	-2.2	3.2	0.4	0.5	-2.8
Average weekly spirits intake	0.6	0.7	2.0	0.7	0.8	1.4	0.9	-0.1	-0.6
Fed-up feelings	0.6	1.1	5.6	-2.4	0.1	0.5	0.6	-0.3	0.5
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.7	0.2	0.7	-1.3	-1.1	0.7	0.7
Medication: Levothyroxine sodium	0.6	1.1	2.2	-0.6	-1.3	1.5	-0.1	0.4	-1.4
Chronic bronchitis/emphysema (father)	0.6	0.7	1.3	-1.1	0.8	-0.8	-0.6	-0.5	0.9
Hip circumference	0.6	2.6	7.3	-2.7	1.0	-1.1	-2.3	-0.8	0.6
Father’s age at death	0.6	0.8	1.7	-0.3	-0.9	0.9	-1.0	1.3	0.7
Worrier / anxious feelings	0.6	1.2	3.3	-1.4	0.1	-1.1	-0.6	0.0	1.8
Birth weight	0.6	1.3	5.6	-0.1	-2.4	1.0	-1.0	0.6	0.3
Leg fat mass (right)	0.6	2.4	6.1	-2.4	1.0	-0.6	-2.5	-1.0	0.6
Age at last live birth	0.6	0.8	1.9	1.0	-0.9	1.1	1.4	-0.1	-0.2
Illnesses of father: Heart disease	0.6	0.8	1.8	-1.4	-0.8	-0.9	0.4	-1.1	0.2
Mood swings	0.6	1.1	2.8	-1.7	1.0	-1.0	-1.0	0.3	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	2.9	-1.7	0.5	-0.4	0.1	-0.9	0.6
Breast cancer (self-reported)	0.6	0.7	1.5	0.8	-0.3	1.2	1.0	0.4	-0.9
Illnesses of father: High blood pressure	0.6	0.7	1.8	1.3	-0.9	-0.7	-1.1	0.2	0.2
Diastolic blood pressure, automated reading	0.6	1.8	6.6	1.0	2.6	-0.7	-0.6	1.5	-0.4
Leg fat mass (left)	0.6	2.5	7.0	-2.4	1.0	-0.6	-2.6	-0.8	0.4
Crohns Disease (2017)	0.5	1.0	3.2	-0.8	-0.4	-0.5	0.8	-1.8	1.1
Irritable Bowel Disease (IBD)	0.5	1.2	2.7	0.9	-0.5	-1.5	1.2	-1.6	-0.0
Reaction Time	0.5	1.0	3.1	-0.2	1.7	-1.0	0.1	-0.1	1.3
HbA1C	0.5	0.6	1.0	1.0	0.9	0.7	-0.5	-0.4	0.9
Systolic Blood Pressure	0.5	2.6	8.1	2.1	-0.2	0.4	1.3	0.9	-2.9
Number of treatments/medications taken	0.5	0.9	2.4	-1.4	1.5	-0.2	-0.7	-0.4	0.2
Current tobacco smoking	0.5	0.8	2.2	-0.5	0.3	1.3	-0.1	-1.5	-0.8
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	2.6	0.7	0.1	-0.3	-0.1	-0.2	1.6
Qualifications: CSEs or equivalent	0.5	0.6	1.5	-1.1	-0.4	1.2	-0.1	-0.9	-0.3
High blood pressure	0.5	1.4	4.5	1.3	2.1	-0.8	0.7	-0.5	-0.9
Multivitamins +/- minerals	0.5	0.6	1.3	0.1	-1.2	1.1	-0.6	0.9	-0.2
Medication: Atenolol	0.5	0.7	2.3	0.8	0.2	-1.5	-0.3	-1.0	-0.2
Sitting height	0.5	3.4	7.1	-1.9	-1.5	-0.4	2.2	-2.7	-1.5
Hearing difficulty/problems with background noise	0.5	0.8	2.1	-1.4	1.1	0.8	0.3	-0.6	-0.6
Mouth/teeth dental problems	0.5	0.8	3.3	-0.4	-1.8	-0.2	0.6	-0.7	0.8
Pain all over the body in last month	0.5	0.6	2.3	0.6	-0.3	0.5	1.5	-0.2	-0.5
Medication: Ramipril	0.5	0.6	2.4	-0.8	0.5	0.0	0.6	-1.5	-0.6
Weight	0.5	2.7	10.4	-3.2	0.7	-0.1	-1.8	-1.3	-0.1
Trunk predicted mass	0.5	2.6	4.8	-1.7	-1.2	1.5	1.5	-1.3	-2.2
Medication: Paracetamol	0.5	0.8	2.8	0.5	-0.2	-0.9	-0.5	0.9	1.7
Migraine (self-reported)	0.5	0.6	1.8	-0.4	0.2	0.2	1.2	-1.4	-0.1
Overall health rating	0.5	1.0	1.8	-1.4	1.0	0.2	-0.9	-1.1	-1.0
Leg pain on walking	0.5	0.6	1.5	-0.5	1.2	0.5	-0.3	-0.5	-1.1
Average weekly red wine intake	0.5	0.7	1.9	-0.7	0.1	1.4	0.8	-0.8	-0.5
Eye problems/disorders: Cataract	0.5	0.6	2.4	-1.6	0.3	-0.6	-0.1	-0.6	-0.7
Medication: Lisinopril	0.5	0.6	2.0	0.0	-0.4	0.3	1.4	0.0	-1.2
Cardiovascular Disease	0.4	1.5	4.0	2.0	0.8	-1.8	-0.2	0.7	-0.6
Systolic blood pressure, automated reading	0.4	1.0	2.6	0.2	1.6	-0.3	-0.8	0.9	-1.4
Vitamin and mineral supplements	0.4	0.5	1.2	1.0	-0.1	-0.1	1.1	-0.6	-0.7
Medication: Metformin	0.4	0.6	2.2	0.0	0.4	0.2	0.3	-1.0	-1.5
Leg fat-free mass (left)	0.4	2.3	5.9	-2.4	-0.3	0.9	-0.1	-1.9	-1.9
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	0.9	-0.3	0.3	0.0	-0.8	-1.0	0.9
Leg predicted mass (left)	0.4	2.4	5.9	-2.4	-0.3	1.0	-0.1	-1.9	-1.9
Had other major operations	0.4	0.5	1.5	-0.0	0.1	-1.2	-0.7	-0.2	0.8
Trunk fat-free mass	0.4	2.5	4.6	-1.7	-1.1	1.5	1.5	-1.3	-2.1
Medication: Lansoprazole	0.4	0.5	1.8	-0.6	0.4	-1.3	-0.0	-0.4	0.6
Exposure to tobacco smoke at home	0.4	0.4	1.7	-1.3	-0.4	-0.7	-0.0	0.3	0.4
Medication: Omeprazole	0.4	0.5	1.1	0.5	-0.1	-1.1	-0.7	-0.7	0.6
Heart disease (mother)	0.4	0.5	1.7	-0.3	1.3	-0.8	-0.7	-0.3	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.1	-0.9	-0.9	-0.1	-0.4	0.3	1.0
Pulse rate, automated reading	0.4	1.3	5.3	0.2	2.3	0.2	0.1	1.1	-1.1
Suffer from ‘nerves’	0.4	0.6	2.8	-0.3	-0.8	0.2	-0.4	1.7	0.2
Hypertension (Self-reported)	0.4	1.2	3.1	1.1	1.8	-0.6	0.5	-0.8	-1.2
Whole body fat-free mass	0.4	2.4	4.4	-2.1	-0.9	1.2	0.8	-1.6	-2.1
Leg fat-free mass (right)	0.4	2.2	6.4	-2.5	-0.2	0.9	-0.3	-1.7	-1.7
Illnesses of father: None of the above (group 1)	0.4	0.5	1.7	0.8	1.3	0.2	0.5	0.4	0.1
Smoking status: Current	0.4	0.6	2.0	-0.7	0.7	0.7	-0.1	-1.4	-0.3
Whole body water mass	0.4	2.5	4.7	-2.2	-0.8	1.3	1.0	-1.7	-2.0
Leg predicted mass (right)	0.4	2.3	6.6	-2.6	-0.3	0.9	-0.3	-1.7	-1.8
Miserableness	0.4	0.6	2.5	-1.6	0.6	0.2	0.8	-0.2	0.5
Guilty feelings	0.4	0.5	0.9	-0.9	-0.4	-0.8	-0.9	-0.5	0.7
Financial situation satisfaction	0.4	0.5	1.2	-0.1	1.1	0.2	-0.7	-0.8	-0.6
Basal metabolic rate	0.4	2.2	5.9	-2.4	-0.6	1.0	0.3	-1.6	-1.7
Average weekly beer plus cider intake	0.4	0.5	1.2	-0.9	-0.1	0.6	-1.1	-0.9	0.2
Heart disease (siblings)	0.4	0.5	1.4	-0.9	0.5	-1.2	-0.1	-0.7	-0.2
Triglycerides	0.3	0.5	1.5	-0.4	0.5	-0.3	-0.8	-1.2	-0.2
Heel T-Score	0.3	2.1	5.8	1.1	-0.0	-2.4	-2.3	0.6	-0.4
BMI	0.3	1.5	3.9	-2.0	1.5	1.1	-1.3	-0.3	0.1
Hand grip strength (left)	0.3	0.9	3.9	-1.1	-2.0	-0.1	0.5	-0.3	0.0
Townsend deprivation index at recruitment	0.3	0.4	0.9	0.4	-0.1	-1.0	-0.9	0.3	0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.8	1.6	1.3	-0.5	-1.1	0.7	-0.6	-0.9
Impedance of arm (right)	0.3	1.5	3.5	-1.8	-1.9	0.7	-0.9	-0.9	-0.5
Comparative body size at age 10	0.3	0.9	2.2	-0.2	-0.9	-1.4	-0.1	-1.5	0.5
Mouth/teeth dental problems: Loose teeth	0.3	0.3	1.3	0.1	0.1	0.7	0.1	-0.3	-1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	1.5	0.6	0.0	0.1	-0.6	1.2	-0.3
Commuting to job workplace: Walk	0.3	0.3	0.9	0.3	-0.7	0.2	1.0	-0.2	-0.1
Wears glasses or contact lenses	0.3	0.3	0.7	-0.3	0.4	0.5	0.9	0.3	-0.7
Arm fat-free mass (left)	0.3	1.7	5.3	-2.3	-0.3	0.7	0.8	-1.4	-1.3
Irritability	0.3	0.4	1.1	-0.9	-1.0	-0.4	-0.2	0.7	0.3
Arm predicted mass (left)	0.3	1.6	5.1	-2.3	-0.6	0.5	0.5	-1.6	-1.1
Body Mass Index (BMI) (2010)	0.2	0.3	0.8	0.4	0.9	0.1	0.6	0.5	0.1
Waist Hip Ratio (WHR)	0.2	0.8	2.5	0.5	0.4	1.6	-1.0	0.2	-1.1
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.9	-0.7	0.2	-0.1	0.6	-0.9	0.0
Impedance of leg (right)	0.2	1.0	3.9	0.4	-2.0	-0.6	0.6	0.2	1.0
Average weekly fortified wine intake	0.2	0.2	1.0	-0.2	-0.3	0.4	-0.2	0.0	-1.0
Impedance of leg (left)	0.2	1.1	3.4	0.3	-1.9	-0.9	-0.1	0.7	1.4
Time employed in main current job	0.2	0.3	0.5	-0.1	-0.7	0.2	0.6	-0.5	-0.6
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.7	0.0	-0.8	0.2	-0.7	0.8	0.2
Impedance of arm (left)	0.2	0.8	2.4	-1.1	-0.8	-0.4	-1.5	-0.5	0.3
Pulse wave reflection index	0.2	0.2	1.0	0.2	-0.2	0.2	-1.0	0.1	-0.3
Headache pain in last month	0.2	0.4	1.5	-0.8	-0.2	-0.3	0.4	-1.2	-0.4
Glaucoma (self-reported)	0.2	0.2	1.1	-0.1	-0.2	-0.1	0.4	-1.1	-0.3
Medication: Amlodipine	0.2	0.3	0.6	0.8	-0.1	0.8	-0.5	0.2	-0.3
Arm fat-free mass (right)	0.2	1.2	3.7	-1.9	-0.1	0.0	0.4	-1.5	-1.1
Shortness of breath walking on level ground	0.2	0.3	0.8	-0.5	0.9	0.3	-0.3	-0.2	-0.7
Medication: Ibuprofen	0.2	0.2	0.4	0.2	-0.4	0.1	-0.7	0.6	0.2
Arm predicted mass (right)	0.2	1.0	2.4	-1.5	-0.1	0.2	0.7	-1.2	-1.2
Eye problems/disorders: Glaucoma	0.2	0.2	0.4	-0.2	-0.5	-0.5	-0.6	0.0	0.4
Medication: Blood pressure	0.2	0.3	0.6	-0.8	-0.7	-0.0	-0.8	0.0	-0.6
Alcohol drinker status: Never	0.2	0.3	1.0	-0.6	0.1	-0.4	1.0	0.2	-0.0
Pain experienced in last month	0.2	0.3	1.0	0.3	-0.4	0.8	1.0	0.3	0.2
Alcohol drinker status: Previous	0.2	0.2	0.7	0.6	0.6	0.0	-0.0	0.8	0.4
Impedance of whole body	0.2	0.8	1.8	-0.4	-1.3	-0.8	-1.2	0.1	1.0
Lung FEV1/FVC ratio	0.1	0.4	1.1	-0.8	-0.6	0.2	-0.6	-0.2	-1.0
Hair Pigment	0.1	2.8	6.0	1.1	-1.2	2.5	-1.4	2.1	-1.4
Tanning	0.1	1.7	5.0	-0.9	-0.0	-2.2	0.4	-2.0	0.0
Ever had hysterectomy (womb removed)	0.1	0.1	0.2	0.0	0.3	-0.4	-0.4	-0.2	-0.1
Hand grip strength (right)	0.1	0.3	0.6	-0.7	-0.7	0.3	0.4	-0.2	-0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.9	0.3	-0.5	-0.4	-0.2	-0.2	-1.0
Alcohol usually taken with meals	0.1	0.1	0.2	0.3	-0.4	-0.5	0.1	0.1	0.0
Hair/balding pattern: Pattern 3	0.1	0.2	0.5	0.1	-0.7	-0.3	-0.7	-0.1	-0.4
Exposure to tobacco smoke outside home	0.1	0.2	0.5	-0.5	0.0	-0.0	-0.4	0.7	0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.3	0.4	0.3	-0.4	0.1	-0.5	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.3	-0.6	0.4	-0.1	0.3	-0.4	0.2
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0

Hub : Genes

MLEC

Models

Trait associations