TWAS hub - SEMA4A

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.1140	0.0370	1.1e-04	0.048	NA	0.058	NA	0.081	8.5e-05	NA	1.6e-05	NA	3.9e-07
2	GTEx	Breast Mammary Tissue	0.1970	0.0850	3.4e-03	0.168	NA	0.154	NA	0.163	5.4e-09	NA	2.5e-08	NA	9.4e-09
3	GTEx	Breast Mammary Tissue (Female)	0.0416	0.0670	2.8e-01	-0.006	NA	-0.010	NA	-0.009	5.5e-01	NA	8.8e-01	NA	8.0e-01
4	GTEx	Esophagus Mucosa	0.3710	0.0700	1.7e-10	0.297	NA	0.309	NA	0.330	3.7e-20	NA	4.7e-21	NA	1.1e-22
5	GTEx	Nerve Tibial	0.2409	0.0608	1.0e-05	0.104	NA	0.141	NA	0.132	8.3e-08	NA	3.7e-10	NA	1.4e-09
6	GTEx	Skin Not Sun Exposed Suprapubic	0.3390	0.0780	1.1e-05	0.310	NA	0.334	NA	0.336	1.8e-17	NA	5.5e-19	NA	3.9e-19
7	GTEx	Skin Sun Exposed Lower leg	0.5120	0.0580	3.9e-16	0.356	NA	0.390	NA	0.387	1.2e-30	NA	3.7e-34	NA	7.6e-34
8	GTEx	Spleen	0.5090	0.1340	1.9e-04	0.243	NA	0.253	NA	0.169	6.3e-07	NA	3.5e-07	NA	4.0e-05
9	GTEx	Stomach	0.1770	0.0630	1.0e-03	0.044	NA	0.018	NA	0.037	3.6e-03	NA	4.6e-02	NA	7.0e-03
10	GTEx	Thyroid	0.4750	0.0640	2.5e-13	0.307	NA	0.286	NA	0.296	6.0e-24	NA	4.3e-22	NA	5.8e-23
11	GTEx	Whole Blood	0.0970	0.0420	2.0e-03	0.134	NA	0.132	NA	0.127	2.4e-12	NA	3.7e-12	NA	9.3e-12
12	METSIM	Adipose	0.1818	0.0483	3.3e-09	0.132	0.075	0.120	0.127	0.126	3.4e-19	2.6e-11	1.4e-17	1.8e-18	2.3e-18
13	NTR	Blood	0.0303	0.0109	1.2e-05	0.006	0.015	0.010	0.015	0.009	4.9e-03	7.5e-06	2.5e-04	8.4e-06	3.8e-04
14	YFS	Blood	0.4123	0.0382	0.0e+00	0.315	0.275	0.328	0.303	0.324	4.2e-106	1.5e-90	3.3e-111	2.8e-101	1.4e-109
15	TCGA	Breast Invasive Carcinoma	0.0145	0.0085	8.3e-03	0.000	0.007	0.000	NA	0.001	2.9e-01	1.2e-02	3.2e-01	NA	1.8e-01
16	TCGA	Kidney Renal Clear Cell Carcinoma	0.0629	0.0297	8.6e-04	0.033	0.038	0.035	NA	0.032	1.0e-04	3.6e-05	7.5e-05	NA	1.5e-04
17	TCGA	Prostate Adenocarcinoma	0.1128	0.0398	3.1e-07	0.083	0.081	0.080	NA	0.080	5.6e-09	7.1e-09	9.8e-09	NA	9.1e-09
18	TCGA	Thyroid Carcinoma	0.1980	0.0610	1.2e-07	0.055	0.058	0.070	NA	0.049	4.1e-06	2.6e-06	2.6e-07	NA	1.4e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Breast Cancer	10.1	24.2	35.6	-5.5	-4.5	-3.7	-4.8	-4.9	-4.5	-4.5	-4.6	-4.9	-4.5	-4.5	-5.2	-6.0	-4.7	-5.5	-3.8	-5.9	-5.8
Ever used hormone-replacement therapy (HRT)	7.9	10.0	15.9	-4.0	-3.0	-2.5	-3.2	-3.3	-2.9	-2.9	-2.7	-3.8	-3.0	-2.9	-3.5	-2.1	-2.7	-3.7	-2.1	-4.0	-3.8
Overall health rating	7.4	16.0	26.9	3.6	5.1	4.8	4.9	3.4	5.1	5.1	3.3	0.9	5.2	5.1	4.6	1.4	5.0	-0.4	2.5	2.3	3.5
Medication for hormone replacement therapy	6.7	7.5	16.6	-3.6	-2.2	-2.0	-2.6	-4.1	-2.2	-2.2	-1.9	-3.8	-2.1	-2.2	-2.6	-2.3	-2.3	-3.7	-0.2	-3.5	-2.9
Long-standing illness, disability or infirmity	5.4	8.2	11.6	3.0	3.3	3.1	3.4	2.2	3.2	3.3	1.1	2.4	3.4	3.3	3.1	0.9	3.4	1.5	3.3	2.5	3.2
Average weekly red wine intake	5.0	7.4	11.3	-3.1	-3.3	-3.1	-3.2	-1.8	-3.2	-3.2	-1.7	-1.7	-3.4	-3.2	-3.3	-1.1	-3.3	-1.1	-1.9	-2.2	-3.0
Medication: Omeprazole (e.g. Zanprol)	4.4	5.3	9.7	2.2	2.9	2.7	2.9	2.7	2.9	3.0	1.3	0.5	2.8	2.9	2.7	0.8	3.1	-0.2	1.0	1.8	1.3
Ever highly irritable/argumentative for 2 days	4.1	5.0	8.6	2.2	2.6	1.6	2.3	1.1	2.3	2.3	1.0	1.3	2.8	2.4	2.5	-1.0	1.6	2.8	2.9	2.8	2.9
Respiratory disease	4.0	8.8	14.3	3.4	3.4	3.8	3.5	2.8	3.4	3.4	2.1	2.5	3.1	3.3	3.4	2.7	3.6	0.9	2.3	2.7	1.5
Frequency of tiredness / lethargy in last 2 weeks	3.8	6.1	8.9	2.8	2.9	2.8	2.9	1.6	2.9	2.9	1.9	1.5	2.9	2.9	2.9	1.3	3.0	1.1	2.8	1.8	2.0
Other serious medical condition/disability diagnosed by doctor	3.7	4.8	8.7	2.0	2.6	2.2	2.5	3.0	2.5	2.5	0.8	1.9	2.4	2.5	2.4	0.3	2.5	1.7	1.9	2.1	2.0
Pain all over the body in last month	3.7	3.9	7.7	2.1	2.2	2.8	2.5	1.7	2.3	2.3	0.7	2.6	2.0	2.2	1.8	-0.3	2.5	-0.2	2.2	1.7	0.2
Osteoarthritis (self-reported)	3.7	4.7	7.8	2.3	2.6	2.5	2.8	2.0	2.7	2.7	1.4	1.5	2.6	2.6	2.1	0.4	2.5	0.3	1.8	1.9	2.1
Crohns Disease (2012)	3.5	5.7	13.0	3.2	2.3	2.2	2.5	0.1	2.3	2.3	1.4	2.9	2.4	2.2	2.5	3.6	2.5	0.8	3.2	2.2	1.6
Reason for reducing amount of alcohol drunk: Health precaution	3.5	4.1	9.5	-2.5	-1.8	-1.4	-1.9	-2.9	-1.8	-1.8	-0.8	-3.0	-1.5	-1.8	-2.0	-1.9	-2.2	-2.3	-1.1	-3.1	-1.0
Crohns Disease (2017)	3.3	7.3	15.2	3.4	2.6	2.5	2.7	1.4	2.6	2.6	1.8	3.2	2.7	2.6	3.2	3.9	2.8	1.5	3.1	3.0	1.1
Financial difficulties in last 2 years	3.3	4.5	10.2	1.9	2.6	3.2	2.7	1.2	2.7	2.7	1.3	0.3	2.5	2.7	2.2	-0.5	2.7	-0.4	1.2	1.5	2.2
Shortness of breath walking on level ground	3.3	3.9	7.0	2.2	2.2	2.1	2.3	2.5	2.2	2.2	0.9	1.3	2.1	2.2	2.3	1.7	2.6	1.1	0.8	1.3	2.0
Asthma (self-reported)	3.3	6.5	9.3	2.9	3.0	3.0	2.9	3.0	2.8	2.9	1.6	2.0	2.6	2.8	3.0	2.3	3.0	1.4	1.5	2.4	1.6
Asthma	3.1	6.1	8.9	2.8	2.8	2.8	2.8	2.9	2.7	2.8	1.7	1.8	2.5	2.7	3.0	2.2	2.9	1.4	1.5	2.4	1.7
Severe depression (siblings)	2.9	3.2	5.6	1.3	2.2	2.0	2.1	1.1	2.3	2.3	2.1	0.4	2.2	2.3	2.3	0.4	2.4	-0.1	1.8	1.2	0.9
Stomach or abdominal pain in last month	2.9	3.6	6.5	1.7	2.4	2.2	2.3	2.0	2.3	2.3	2.2	0.0	2.1	2.3	2.3	0.5	2.6	-0.4	0.2	1.4	1.1
Lung cancer (father)	2.8	3.3	5.1	2.2	2.0	1.6	1.9	1.6	1.9	1.9	2.0	1.4	2.1	2.0	1.9	2.1	1.9	0.8	1.2	1.9	1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	2.6	3.4	5.6	2.1	2.1	2.1	2.3	1.8	2.1	2.2	1.4	1.6	1.9	2.1	2.0	1.7	2.4	0.0	0.9	1.6	1.5
Depression (self-reported)	2.5	2.9	5.9	2.1	1.7	1.4	1.7	1.9	1.6	1.7	2.1	2.4	1.5	1.7	1.9	1.4	1.4	1.3	1.7	2.1	0.3
Alcohol intake frequency.	2.5	5.8	10.4	2.7	3.1	2.9	3.2	1.6	3.1	3.1	1.1	1.1	3.1	3.1	2.8	0.8	3.1	-0.5	1.5	1.5	1.1
Smoking status: Current	2.5	3.9	6.9	1.7	2.4	2.1	2.6	1.2	2.5	2.5	0.5	0.9	2.4	2.5	2.3	1.8	2.6	-0.5	2.5	1.2	0.6
Mouth/teeth dental problems: Bleeding gums	2.4	3.2	7.5	1.7	2.1	2.4	2.1	0.1	2.0	2.1	1.6	1.3	2.1	2.0	1.6	1.0	2.0	-0.2	2.7	1.3	1.1
Medication for cholesterol	2.4	3.7	15.1	2.7	0.9	0.7	1.2	2.4	0.9	0.9	0.3	3.6	0.9	0.9	1.2	1.6	1.2	3.9	0.7	3.2	1.8
Blood Red Count	2.3	21.8	32.0	4.2	5.2	4.7	5.2	3.8	5.3	5.3	4.9	2.9	5.6	5.3	5.2	1.8	4.6	3.6	4.9	5.7	4.0
Frequency of depressed mood in last 2 weeks	2.3	3.3	5.5	2.3	1.8	1.7	1.9	1.5	1.9	1.9	1.5	1.4	1.8	1.8	2.1	2.3	2.0	1.2	1.2	1.7	1.9
Chest pain or discomfort	2.3	3.3	8.2	2.1	2.2	2.6	2.2	0.3	2.1	2.2	-0.1	0.6	2.1	2.1	2.1	2.0	2.9	-1.1	1.4	0.3	0.8
Age at last live birth	2.3	3.3	6.2	-1.7	-2.4	-2.2	-2.4	-0.3	-2.4	-2.4	-0.5	-0.8	-2.5	-2.4	-2.2	0.0	-2.3	0.9	-2.2	-0.5	0.1
Osteoporosis (self-reported)	2.3	2.8	4.4	2.1	1.9	1.4	1.8	1.8	1.8	1.8	1.2	1.3	1.9	1.9	1.9	0.9	1.7	1.4	0.8	1.6	2.1
Ever depressed for a whole week	2.3	2.9	5.0	1.8	2.0	1.7	1.8	0.9	2.0	2.0	0.6	1.0	2.0	2.0	2.2	0.8	1.8	1.1	1.8	1.8	2.0
Current tobacco smoking	2.2	3.6	6.9	1.6	2.4	2.1	2.5	0.9	2.4	2.4	0.1	0.8	2.4	2.4	2.2	1.6	2.4	-0.6	2.6	1.1	0.4
Multivitamins +/- minerals	2.2	2.8	10.1	1.9	1.3	0.4	1.2	1.9	1.3	1.2	1.3	2.2	1.6	1.3	1.5	1.1	0.6	3.2	1.4	2.2	2.2
Medication: Simvastatin	2.2	3.2	5.3	1.6	2.0	2.3	2.2	1.3	2.0	2.1	1.9	1.4	2.0	2.0	1.7	1.0	1.6	0.2	2.1	1.1	2.0
Headache pain in last month	2.2	3.8	6.7	1.5	2.1	2.0	2.3	2.3	2.2	2.2	2.2	1.1	2.1	2.2	1.9	-0.0	1.8	1.5	1.4	2.6	2.1
Age at first live birth	2.2	3.9	7.8	-1.6	-2.4	-2.8	-2.5	-0.7	-2.5	-2.5	-1.0	-0.2	-2.4	-2.4	-2.1	-2.0	-2.8	1.6	-1.7	-0.0	-0.3
Schizophrenia vs Biploar Disorder	2.1	2.7	6.0	-1.3	-2.1	-2.0	-2.0	-0.3	-2.0	-2.0	-1.6	-1.0	-2.2	-2.1	-1.6	0.7	-1.7	0.2	-2.5	-1.4	-0.4
Taking other prescription medications	2.1	3.2	6.5	1.9	2.1	2.5	2.3	1.1	2.1	2.1	0.1	1.4	2.0	2.1	1.9	1.1	2.1	-0.3	2.5	0.6	1.1
Basal cell carcinoma (self-reported)	2.1	2.4	4.2	1.3	2.0	1.7	2.0	1.5	2.0	2.0	1.7	0.6	1.8	2.0	1.6	-0.6	1.9	-0.7	0.5	1.4	0.8
Trunk fat percentage	2.0	8.0	15.2	2.7	3.7	3.6	3.7	1.9	3.7	3.8	0.8	1.0	3.7	3.7	3.2	0.9	3.9	-1.3	2.1	0.9	1.7
Body fat percentage	2.0	7.8	14.3	2.5	3.7	3.7	3.7	1.5	3.7	3.7	0.6	0.8	3.7	3.7	3.2	0.4	3.8	-1.5	2.3	0.7	1.7
Leg fat percentage (right)	2.0	7.4	14.0	2.4	3.5	3.4	3.6	0.9	3.5	3.6	0.5	0.7	3.7	3.5	3.1	0.0	3.5	-1.0	2.7	1.0	2.3
Number of self-reported non-cancer illnesses	2.0	3.4	6.2	1.5	2.2	2.2	2.2	0.9	2.2	2.2	1.4	0.7	2.2	2.2	2.1	2.0	2.4	-0.1	2.5	0.9	1.0
Illnesses of father: High blood pressure	2.0	2.5	5.3	-2.3	-1.8	-1.1	-1.8	-1.6	-1.6	-1.6	0.0	-2.0	-1.7	-1.6	-1.8	-0.0	-1.8	-1.7	-1.4	-1.1	-1.4
Waist circumference	1.9	6.9	13.1	2.8	3.4	2.9	3.3	0.9	3.3	3.4	1.3	0.5	3.6	3.4	3.1	1.2	3.5	-0.2	2.9	0.6	1.9
Allergy	1.9	4.3	9.0	-2.1	-1.9	-1.8	-2.1	-2.3	-1.9	-2.0	-1.9	-2.2	-1.7	-1.9	-2.2	-2.8	-2.0	-2.0	-1.8	-3.0	-1.2
Leg fat percentage (left)	1.9	6.7	12.6	2.3	3.4	3.3	3.4	0.7	3.4	3.4	0.3	0.5	3.5	3.4	3.0	0.4	3.4	-1.4	2.6	0.7	1.7
Had menopause	1.8	2.3	6.2	-1.9	-1.0	-0.6	-1.2	-1.6	-1.1	-1.0	-1.2	-2.4	-0.9	-1.0	-1.2	-1.4	-0.6	-2.5	-2.1	-2.5	-0.8
Mouth/teeth dental problems	1.8	2.8	5.6	-2.3	-1.9	-2.2	-1.9	-0.3	-1.8	-1.8	-0.7	-1.6	-1.8	-1.8	-1.6	-1.5	-1.9	-0.0	-2.4	-1.4	-0.6
Medication: Atorvastatin	1.8	2.2	7.9	-1.3	-1.1	-0.9	-1.2	-2.1	-1.2	-1.2	-1.2	-1.3	-1.1	-1.2	-1.2	0.4	-1.2	-2.8	-0.5	-2.4	-2.1
Irritable Bowel Disease (IBD)	1.7	4.1	8.9	2.2	1.8	2.0	1.9	1.1	1.9	1.9	1.3	2.4	1.9	1.9	2.5	3.0	2.0	1.7	2.4	2.7	0.8
Trunk fat mass	1.7	7.4	13.0	2.9	3.5	3.2	3.5	1.8	3.5	3.5	0.9	1.1	3.6	3.5	3.2	1.0	3.6	-0.3	2.4	1.0	2.1
Had other major operations	1.7	2.1	3.8	1.7	1.7	2.0	1.7	1.3	1.7	1.7	0.9	0.9	1.8	1.7	1.4	1.7	1.9	0.3	1.0	0.4	0.7
Noisy workplace	1.7	2.1	3.9	1.5	1.7	1.9	1.8	0.3	1.8	1.8	1.3	0.0	2.0	1.8	1.4	0.4	1.7	-0.5	1.7	0.7	1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.7	2.0	3.5	1.4	1.8	0.8	1.5	1.1	1.7	1.6	0.8	0.8	1.9	1.7	1.9	-0.1	1.5	0.9	1.8	1.7	0.9
Commuting to job workplace: Cycle	1.7	2.1	6.7	1.7	0.8	0.7	1.1	2.2	0.9	0.9	0.7	2.4	0.8	0.9	1.1	0.5	1.1	2.6	0.1	2.2	1.9
Age at First Birth	1.6	2.3	4.5	-1.0	-2.0	-2.0	-2.1	-0.4	-2.1	-2.1	0.3	-0.1	-2.0	-2.0	-1.2	0.7	-1.6	1.5	-2.0	-0.3	0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.6	2.2	4.0	1.5	1.7	1.8	1.8	0.5	1.8	1.8	0.8	0.6	1.8	1.8	1.9	0.7	2.0	-0.4	1.9	0.8	1.3
Gout (self-reported)	1.6	2.2	5.2	2.0	1.3	1.6	1.5	0.2	1.3	1.3	1.1	1.3	1.4	1.3	1.6	2.3	1.9	0.9	1.5	0.7	2.1
Mouth/teeth dental problems: Loose teeth	1.6	1.9	4.0	2.0	1.3	1.4	1.7	0.8	1.3	1.4	0.5	1.4	1.4	1.3	1.2	1.9	1.4	1.1	1.4	1.4	1.1
Emphysema/chronic bronchitis	1.6	1.9	4.5	1.7	1.2	1.9	1.7	1.1	1.4	1.5	0.5	1.7	1.0	1.4	1.1	1.6	2.1	-0.6	0.9	1.1	-0.7
Leg fat mass (right)	1.6	6.4	12.1	2.6	3.2	2.9	3.2	0.8	3.2	3.2	0.4	1.1	3.5	3.2	2.9	0.1	3.2	-0.3	3.0	0.8	2.2
Illnesses of father: Heart disease	1.6	2.2	3.8	-1.0	-1.8	-1.6	-1.7	-1.8	-1.9	-1.9	-1.3	0.4	-1.8	-1.9	-1.6	-0.9	-1.8	0.0	-0.2	-1.4	-1.1
Arm fat percentage (left)	1.6	6.2	11.6	2.5	3.3	3.4	3.3	1.1	3.2	3.3	0.1	0.9	3.2	3.2	2.7	-0.0	3.4	-1.9	2.4	0.1	0.7
Ever had bowel cancer screening	1.6	1.9	4.1	-1.5	-1.2	-1.2	-1.4	-1.9	-1.3	-1.3	-1.9	-2.0	-1.0	-1.3	-1.0	-1.2	-1.0	-1.0	-0.9	-1.8	-0.9
Medication: Blood pressure	1.6	3.0	13.3	-2.4	-1.1	-0.7	-1.2	-1.9	-1.0	-1.0	0.2	-3.0	-1.1	-1.0	-1.1	-0.1	-0.6	-3.6	-1.4	-3.0	-1.7
Pain type(s) experienced in last month: Hip pain	1.6	2.0	5.9	1.3	1.6	1.9	1.6	0.8	1.6	1.7	0.6	0.2	1.5	1.6	1.8	1.9	2.4	-0.4	0.8	0.6	0.9
Unable to work because of sickness or disability	1.6	2.1	4.4	1.6	1.7	1.7	1.9	1.2	1.8	1.8	0.2	0.7	1.8	1.8	1.4	1.4	2.1	-0.4	0.5	0.3	1.4
Body Mass Index (BMI) (2010)	1.5	2.1	6.7	-1.5	-0.8	-0.6	-0.9	-1.5	-0.8	-0.8	-2.4	-1.6	-0.8	-0.8	-1.2	-2.6	-0.7	-2.0	-0.8	-2.1	-1.7
Qualifications: CSEs or equivalent	1.5	2.0	3.2	1.1	1.6	1.3	1.5	1.6	1.5	1.5	1.4	0.2	1.6	1.5	1.7	0.8	1.2	1.2	0.9	1.8	1.6
Diverticular disease/diverticulitis (self-reported)	1.5	1.8	2.9	1.4	1.5	1.6	1.5	1.6	1.5	1.5	1.5	1.4	1.3	1.4	1.5	0.4	1.7	0.8	0.9	1.5	0.4
Arm fat percentage (right)	1.5	5.8	10.3	2.3	3.2	3.2	3.2	1.0	3.1	3.2	-0.0	0.9	3.2	3.1	2.5	-0.4	3.2	-1.7	2.5	-0.0	0.9
Whole body fat mass	1.5	6.2	11.3	2.6	3.2	3.1	3.2	1.2	3.2	3.3	0.4	1.0	3.4	3.2	2.8	0.4	3.3	-0.6	2.5	0.6	1.8
Leg fat mass (left)	1.5	6.0	11.5	2.6	3.2	2.8	3.1	0.8	3.1	3.2	0.3	0.9	3.4	3.1	2.8	0.4	3.1	-0.4	2.8	0.7	2.0
Neuroticism	1.4	3.3	5.5	2.3	2.0	2.1	1.9	1.2	2.0	2.0	1.4	1.4	2.0	2.0	2.3	1.5	2.3	0.5	1.0	2.1	1.6
Diabetes (mother)	1.4	1.8	6.7	1.6	1.2	1.6	1.6	0.8	1.4	1.4	1.4	0.9	1.2	1.3	1.1	2.6	1.8	-1.3	0.6	0.2	0.4
Frequency of tenseness / restlessness in last 2 weeks	1.4	2.2	5.4	1.6	1.6	1.9	1.8	1.3	1.7	1.7	1.2	0.8	1.4	1.6	1.8	1.9	2.3	0.1	0.5	1.0	0.7
Hair/balding pattern: Pattern 2	1.4	1.8	3.8	-1.7	-1.1	-1.2	-1.3	-1.7	-1.1	-1.1	-1.5	-1.4	-1.1	-1.1	-0.8	-1.5	-1.2	-1.9	-1.0	-1.4	-1.5
Arm fat mass (right)	1.4	5.9	11.0	2.6	3.2	3.0	3.1	0.9	3.1	3.2	0.2	0.9	3.3	3.1	2.7	-0.1	3.1	-0.6	2.9	0.3	1.6
Length of working week for main job	1.4	1.5	4.4	1.1	1.3	1.3	1.5	-0.5	1.4	1.4	1.0	0.3	1.6	1.4	1.2	-0.7	1.4	0.7	2.1	1.3	0.6
Birth weight of first child	1.4	2.5	5.8	2.4	1.4	1.7	1.6	2.0	1.4	1.4	1.8	2.1	1.1	1.4	1.3	2.1	1.8	0.7	1.0	1.6	0.6
Medication: Omeprazole	1.4	1.6	3.2	1.4	1.6	1.6	1.6	1.5	1.6	1.6	0.4	0.1	1.4	1.6	1.4	1.0	1.8	-0.5	0.2	1.0	0.7
Systolic Blood Pressure	1.3	6.4	20.1	-3.1	-1.9	-2.1	-2.1	-2.5	-1.9	-1.9	0.1	-4.5	-1.6	-1.9	-1.8	-1.1	-2.1	-4.1	-3.5	-3.8	-1.3
Happiness	1.3	1.6	2.9	-0.3	-1.5	-1.6	-1.6	-1.1	-1.6	-1.6	-1.5	-0.0	-1.6	-1.6	-1.0	0.1	-1.3	-0.4	-1.4	-0.7	-1.7
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.5	4.7	1.3	1.1	0.8	1.3	1.4	1.0	1.0	1.0	1.1	1.1	1.0	0.9	-0.2	0.6	1.9	0.8	1.6	2.2
Qualifications: O levels/GCSEs or equivalent	1.3	2.1	4.8	-1.0	-1.6	-2.2	-1.9	-0.8	-1.8	-1.9	-0.6	-0.5	-1.6	-1.8	-1.5	-0.8	-2.1	1.6	-0.5	-0.8	-1.1
Medication for pain relief, constipation, heartburn	1.3	2.3	4.5	-1.0	-1.9	-2.1	-2.0	-0.7	-2.0	-2.0	-1.0	-0.2	-2.0	-2.0	-1.5	0.6	-1.5	1.1	-2.0	-0.7	-0.7
Mood swings	1.3	2.3	4.1	1.7	1.9	1.7	1.7	0.8	1.8	1.8	1.7	0.4	1.9	1.9	2.0	0.9	1.8	0.1	1.1	1.3	1.0
Illnesses of father: None of the above (group 1)	1.3	1.6	5.8	1.3	1.1	0.2	1.2	1.9	1.1	1.1	0.7	1.0	1.3	1.2	0.9	0.5	0.5	2.4	0.5	1.8	1.8
Arm fat mass (left)	1.3	5.4	9.8	2.6	3.0	3.0	3.0	0.9	3.0	3.0	0.3	0.9	3.1	3.0	2.5	0.0	3.1	-0.9	2.6	0.1	1.3
Medication: Bendroflumethiazide	1.3	1.9	3.6	-1.6	-1.5	-1.4	-1.5	-1.2	-1.5	-1.5	-0.5	-0.9	-1.5	-1.5	-1.3	-0.2	-1.3	-1.8	-1.4	-1.9	-1.3
Coronary Artery Disease (CAD)	1.2	1.4	4.7	-1.4	0.0	0.0	0.0	-1.9	0.0	0.0	-2.0	-1.3	0.0	0.0	-1.4	-1.3	-1.1	-2.2	-0.5	-2.0	0.0
Lung FEV1/FVC ratio	1.2	6.3	15.1	2.5	2.5	2.0	2.6	3.9	2.6	2.6	1.2	1.9	2.6	2.6	2.6	0.6	1.9	2.9	0.4	3.9	2.6
High blood pressure (mother)	1.2	1.7	6.7	-1.5	-1.1	-0.9	-1.2	-1.5	-1.1	-1.1	0.1	-1.9	-1.0	-1.1	-1.2	-1.2	-0.9	-2.6	-1.1	-1.9	-0.3
Myopia	1.2	1.7	4.8	-2.2	-1.1	-1.6	-1.8	-0.4	-1.4	-1.4	-0.0	-1.9	-1.1	-1.3	-0.7	-1.0	-1.7	1.0	-1.4	-0.6	0.3
Blood White Count	1.1	7.9	20.2	2.2	3.2	2.8	3.3	-1.7	3.3	3.3	0.9	-0.6	3.2	3.3	2.5	-2.2	2.6	-4.5	4.1	-0.9	-2.6
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	2.4	1.2	1.4	1.1	1.2	0.5	1.4	1.4	1.3	-0.3	1.5	1.4	1.0	-0.1	0.9	0.3	0.7	0.5	1.2
Leg pain on walking	1.1	1.4	2.9	0.8	1.5	1.7	1.3	0.0	1.5	1.5	-0.2	-0.1	1.6	1.5	1.4	-0.7	1.2	-0.4	1.5	0.5	1.2
Depression (Nagel 2018)	1.0	1.5	2.8	1.1	1.4	1.4	1.5	0.6	1.4	1.4	0.9	0.6	1.4	1.4	1.5	0.8	1.7	0.1	1.5	0.9	1.1
LDL Cholesterol	1.0	1.5	8.0	-2.0	-0.3	-0.9	-0.8	-2.5	-0.4	-0.4	-0.6	-2.8	0.2	-0.3	-0.6	-1.7	-1.1	-0.9	-0.1	-1.0	0.6
Waist Hip Ratio (WHR)	1.0	4.4	9.4	2.2	2.1	1.6	2.5	0.9	2.3	2.3	3.1	0.2	2.5	2.3	2.3	2.3	2.7	0.7	1.5	1.1	2.5
Neuroticism score	1.0	2.1	3.9	2.0	1.6	1.6	1.5	0.9	1.5	1.5	1.1	0.7	1.6	1.5	1.9	1.5	1.8	0.7	0.3	1.5	1.8
Wheeze or whistling in the chest in last year	1.0	1.8	4.5	1.4	1.6	2.0	1.8	0.8	1.7	1.8	-0.2	0.1	1.5	1.7	1.4	1.3	2.1	-1.0	0.3	0.3	0.2
Family relationship satisfaction	1.0	1.3	2.8	-0.7	-1.4	-1.7	-1.4	-0.6	-1.5	-1.5	-1.5	0.1	-1.4	-1.4	-0.8	0.1	-1.4	0.5	-1.3	-0.2	-0.7
Miserableness	1.0	1.7	3.9	2.0	1.4	1.2	1.4	0.9	1.4	1.4	1.0	0.8	1.3	1.4	1.7	1.6	1.3	0.5	1.0	1.4	0.8
Guilty feelings	1.0	1.5	5.4	1.4	0.7	0.6	0.7	-0.0	0.6	0.6	0.7	1.6	0.8	0.6	1.2	1.4	0.8	2.3	1.9	1.8	1.5
Mother’s age at death	1.0	1.2	3.7	-1.0	-1.4	-0.6	-1.5	0.1	-1.5	-1.5	-0.9	-0.5	-1.5	-1.5	-1.2	-0.3	-1.1	0.4	-1.9	-0.5	-0.2
Ovarian Cancer	0.9	1.2	3.5	-0.9	-1.3	-1.2	-1.2	-1.6	-1.2	-1.2	-0.7	-0.4	-1.3	-1.2	-0.9	0.2	-1.0	-0.9	0.7	-0.6	-1.9
Prostate Cancer	0.9	1.3	6.6	0.4	-0.4	-0.3	-0.3	1.0	-0.3	-0.3	0.1	1.1	-0.2	-0.3	-0.0	1.5	-0.4	2.6	-1.2	2.1	2.3
BMI	0.9	5.4	9.2	1.8	3.0	2.9	2.8	-0.5	2.9	3.0	-0.8	-0.3	3.0	2.9	2.2	-1.5	3.0	-2.8	2.8	-1.2	0.2
Systolic blood pressure, automated reading	0.9	2.6	11.4	-1.7	-0.7	-0.6	-0.9	-1.6	-0.6	-0.6	-0.3	-3.4	-0.4	-0.6	-0.7	-0.0	-0.5	-3.4	-2.2	-3.2	0.1
Supplements: Glucosamine	0.9	1.1	3.1	-0.9	-1.0	-1.0	-0.9	-0.5	-1.0	-1.0	-1.8	-1.1	-1.1	-1.0	-1.1	-1.1	-0.9	-0.6	-1.3	-1.4	-1.1
Medication: Atenolol	0.9	1.1	3.6	-0.8	-1.0	-0.7	-0.7	-1.8	-0.9	-0.8	-0.7	-0.1	-0.7	-0.9	-1.3	0.2	-1.1	-1.8	0.7	-1.9	-0.9
Body mass index (BMI)	0.9	3.9	6.7	1.7	2.5	2.5	2.4	-0.3	2.4	2.5	-0.7	0.0	2.5	2.4	1.9	-0.8	2.6	-2.3	2.6	-0.8	0.1
Number of incorrect matches in round	0.9	1.4	8.3	0.7	0.6	0.7	0.7	1.2	0.5	0.5	0.6	1.6	0.5	0.5	0.9	1.2	1.1	2.9	0.8	1.7	1.8
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	6.6	1.0	0.2	-0.4	0.2	1.0	0.2	0.2	0.6	1.5	0.4	0.2	0.5	2.4	-0.2	2.6	1.1	1.5	0.1
Weight	0.9	4.4	7.7	2.6	2.6	2.2	2.6	1.0	2.6	2.6	0.6	0.8	2.8	2.6	2.4	0.7	2.7	0.6	2.4	0.5	2.1
Alcohol intake versus 10 years previously	0.9	1.3	6.1	-0.8	-0.4	-0.2	-0.4	-2.4	-0.4	-0.4	-0.6	-1.6	-0.2	-0.4	-0.7	0.9	-0.2	-2.5	0.6	-2.4	-0.6
Health satisfaction	0.9	1.2	2.5	0.8	1.3	0.6	0.9	1.3	1.2	1.2	0.7	0.2	1.6	1.3	1.6	-0.3	1.0	0.9	-0.1	1.1	1.6
Qualifications: College or University degree	0.9	3.0	6.6	-0.9	-2.1	-2.5	-2.2	0.0	-2.1	-2.2	-0.3	0.8	-2.0	-2.1	-1.9	-0.3	-2.6	2.3	-1.6	0.4	-0.5
Financial situation satisfaction	0.9	1.1	1.7	0.9	1.3	1.1	1.2	1.1	1.3	1.3	1.3	0.0	1.3	1.3	1.2	0.9	1.1	0.1	0.0	1.1	1.0
Schizophrenia (2018)	0.8	1.7	5.7	1.1	0.8	0.8	1.0	1.2	0.9	0.9	1.4	1.3	1.0	0.9	1.1	1.3	0.5	2.4	1.2	2.2	1.8
Blood Platelet Count	0.8	9.4	22.8	2.4	3.8	3.3	4.0	0.8	4.0	4.0	4.8	0.6	4.2	4.0	2.6	-0.5	3.2	-1.9	2.8	2.1	0.1
Medication: Metformin	0.8	1.1	2.2	0.8	1.5	1.3	1.3	0.2	1.4	1.4	0.1	-0.1	1.5	1.4	0.8	-0.6	1.1	-0.2	1.2	0.3	1.0
Mouth/teeth dental problems: Dentures	0.8	1.4	4.6	2.1	1.1	1.4	1.3	0.3	1.1	1.1	-0.3	1.1	0.9	1.1	1.2	2.1	1.5	-0.6	1.1	0.3	-0.3
Pulse wave Arterial Stiffness index	0.8	0.9	2.2	0.2	1.2	1.0	1.0	0.6	1.2	1.2	1.5	-0.4	1.2	1.2	1.1	1.0	1.4	0.0	0.7	0.2	0.3
Tense / ‘highly strung’	0.8	1.3	3.6	0.8	1.3	1.3	1.0	0.5	1.3	1.3	1.3	-0.1	1.5	1.3	1.5	1.9	1.2	0.2	0.1	1.0	1.3
Blood clot in the leg (DVT)	0.8	1.1	3.4	0.3	1.2	0.9	1.2	-0.4	1.2	1.2	1.9	-0.8	1.2	1.2	0.9	0.3	1.2	-1.1	1.2	0.1	-0.3
Average weekly beer plus cider intake	0.8	1.1	2.8	0.5	1.3	1.1	1.4	0.9	1.4	1.4	1.4	-0.2	1.3	1.3	0.8	-0.3	1.7	-0.3	0.4	0.1	1.2
Risk taking	0.8	1.2	5.3	0.6	0.8	0.7	1.0	0.2	0.9	0.9	1.0	0.8	0.9	0.8	0.4	1.1	0.5	1.8	2.3	1.4	1.4
Deep venous thrombosis (DVT) (self-reported)	0.8	1.1	2.9	0.5	1.2	1.0	1.2	-0.5	1.2	1.3	1.7	-0.5	1.2	1.2	1.0	0.5	1.2	-1.1	1.3	0.2	-0.4
Depressed Affect (Nagel 2018)	0.7	1.5	2.8	1.3	1.5	1.6	1.3	-0.1	1.5	1.4	1.0	-0.0	1.5	1.5	1.7	1.4	1.5	-0.6	1.3	0.9	0.2
Worry (Nagel 2018)	0.7	1.5	3.5	1.3	1.0	0.7	0.8	1.5	1.0	0.9	1.6	1.1	1.1	1.0	1.2	0.9	0.9	1.9	0.5	1.7	1.7
Heel T-Score	0.7	5.9	19.5	-1.1	-2.8	-2.4	-2.2	-4.4	-2.7	-2.7	-3.9	0.0	-2.5	-2.7	-2.5	-0.8	-2.7	-0.4	1.1	-1.8	-2.0
Number of treatments/medications taken	0.7	1.2	4.5	1.0	1.3	1.5	1.3	-0.4	1.2	1.3	-0.1	0.2	1.4	1.2	1.2	0.3	0.9	-1.3	2.1	-0.5	-0.1
Maternal smoking around birth	0.7	1.0	3.8	-0.6	0.8	0.7	0.5	-0.9	0.8	0.8	1.1	-1.9	0.9	0.8	0.4	-1.3	0.3	-1.4	1.5	-0.8	-0.1
Relative age voice broke	0.7	1.0	3.7	-1.2	-1.0	-1.4	-1.1	-1.9	-0.9	-1.0	-0.7	-0.6	-0.5	-0.9	-0.9	-1.2	-1.5	0.5	0.2	-0.6	-0.4
Forced vital capacity (FVC)	0.7	2.6	20.0	1.0	-1.0	-2.0	-0.8	1.6	-1.1	-1.1	0.2	2.2	-0.9	-1.0	-0.4	0.1	-1.3	4.5	-0.3	1.9	1.3
Diabetes (self-reported)	0.7	1.1	2.8	0.9	1.3	1.2	1.3	0.2	1.3	1.3	1.7	-0.4	1.4	1.3	0.9	0.2	1.2	-0.5	1.0	0.2	1.1
Fluid intelligence score	0.7	1.4	3.8	-0.5	-1.5	-1.6	-1.5	-0.5	-1.4	-1.4	-1.3	-0.4	-1.4	-1.4	-0.8	1.0	-0.9	-0.2	-1.9	-1.1	-0.6
Time employed in main current job	0.7	0.8	3.7	-0.7	-0.4	-0.1	-0.3	-0.9	-0.3	-0.3	-0.1	-1.1	-0.4	-0.3	-0.6	-1.9	-0.2	-1.7	-0.7	-1.1	-1.1
Falls in the last year	0.7	1.0	5.8	-1.1	0.3	0.2	0.2	0.9	0.3	0.3	-1.5	-1.8	0.2	0.3	-0.1	-2.4	-0.0	-0.9	-1.6	-0.4	0.3
Forced expiratory volume in 1-second (FEV1)	0.7	2.3	17.7	1.2	-0.6	-1.5	-0.4	2.0	-0.6	-0.6	0.1	2.1	-0.5	-0.5	0.1	-0.2	-1.0	4.2	-0.5	2.4	1.5
Medication: Lansoprazole	0.7	0.8	3.1	0.4	1.0	0.8	1.1	-0.1	1.0	1.0	-0.3	1.2	0.9	1.0	0.5	-0.9	1.1	-0.1	1.8	0.6	0.2
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	4.3	-0.9	-1.1	-1.0	-1.2	-0.2	-1.1	-1.1	-0.9	-1.1	-1.3	-1.1	-1.3	-1.4	-0.9	-0.1	-2.1	-0.5	-0.3
Pulse wave peak to peak time	0.7	0.8	1.8	-0.1	-1.2	-1.1	-1.0	-0.3	-1.1	-1.2	-1.2	0.5	-1.1	-1.2	-1.0	-0.6	-1.4	0.4	-0.8	-0.1	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	1.4	0.4	1.1	1.2	1.1	-0.2	1.2	1.2	0.2	-0.7	1.2	1.1	1.0	-1.1	0.5	-0.7	1.2	0.6	0.9
Supplements: Vitamin C	0.7	0.8	1.9	-0.6	-1.1	-0.3	-0.9	-0.5	-1.0	-1.0	-0.9	-0.1	-1.1	-1.1	-1.4	0.4	-0.6	-0.5	-1.1	-1.2	-1.2
Wears glasses or contact lenses	0.7	0.8	2.2	0.1	1.0	1.4	0.9	1.3	1.0	1.0	0.8	-0.3	1.0	1.0	0.9	0.2	0.8	-0.1	0.0	0.9	1.5
Ever taken oral contraceptive pill	0.7	0.8	2.3	0.7	1.1	1.3	1.1	-0.1	1.1	1.1	1.2	-0.2	0.9	1.1	0.9	-0.1	0.7	-1.5	0.7	0.6	-0.2
Hearing aid user	0.7	0.8	2.0	1.0	0.7	0.3	0.8	1.1	0.7	0.7	-0.1	1.2	0.7	0.7	1.2	0.4	1.0	1.4	1.4	0.8	-0.1
High cholesterol (Self-reported)	0.7	1.3	5.6	-1.5	-0.5	-0.3	-0.7	-1.7	-0.6	-0.6	-0.6	-1.5	-0.5	-0.6	-0.7	-0.7	-1.0	-2.4	-0.3	-1.9	-1.3
Medication: Lisinopril	0.7	0.9	1.8	-1.2	-1.1	-0.4	-0.9	-1.1	-1.0	-1.0	-0.1	-0.3	-1.2	-1.0	-1.2	-1.0	-0.7	-1.3	-0.1	-1.1	-1.3
Supplements: Calcium	0.7	0.8	3.8	0.9	0.7	0.6	0.6	1.8	0.7	0.7	0.8	0.5	0.5	0.6	0.7	1.9	1.1	-0.4	-1.1	0.3	0.1
Alzheimer’s Disease (in father)	0.6	0.7	3.9	-0.3	0.5	1.1	0.5	0.5	0.6	0.6	0.4	-1.2	0.2	0.5	0.3	-0.5	1.3	-2.0	-0.9	-0.7	0.4
Verbal and Numeric Reasoning (VNR)	0.6	1.4	7.6	-0.8	-1.3	-1.3	-1.3	0.5	-1.2	-1.2	-1.3	-0.7	-1.3	-1.2	-0.7	0.5	-0.8	-0.5	-2.8	-1.2	-0.6
Mean Putamen Volume	0.6	0.7	4.8	-1.0	0.4	-0.2	0.1	-0.8	0.4	0.4	0.2	-2.2	0.6	0.4	0.5	-2.0	0.0	-0.5	-0.2	-0.2	0.3
HbA1C	0.6	0.7	1.4	-1.1	-1.0	-0.8	-0.9	-0.6	-0.7	-0.9	0.6	-0.8	-1.1	-0.9	-1.1	-1.2	-1.1	0.1	-0.4	-0.1	-0.3
Ulcerative Colitis	0.6	0.9	3.0	1.0	0.7	1.0	0.8	0.3	0.8	0.7	0.9	1.1	0.7	0.7	1.1	1.7	1.1	0.6	1.2	0.9	0.9
Smoking Status	0.6	1.4	3.3	0.4	1.5	1.4	1.5	0.0	1.6	1.6	0.5	-0.5	1.6	1.6	1.2	0.6	1.3	-0.9	1.8	0.4	0.4
Medication: Co-codamol	0.6	0.7	4.5	-0.3	0.4	0.7	0.2	-1.2	0.4	0.4	-0.2	-1.6	0.4	0.4	0.3	-1.1	0.2	-2.1	0.4	-0.6	-0.3
Hayfever, allergic rhinitis or eczema	0.6	1.2	5.1	0.9	0.1	0.0	0.3	1.0	0.1	0.1	0.4	2.0	-0.1	0.1	0.7	1.9	-0.0	2.2	1.2	2.2	0.2
Hip circumference	0.6	2.7	4.9	2.0	2.1	1.9	2.0	0.7	2.1	2.1	0.2	0.4	2.2	2.1	2.0	0.7	2.1	-0.2	1.8	0.2	0.7
Worrier / anxious feelings	0.6	1.1	3.3	1.8	0.8	0.8	0.8	1.4	0.7	0.7	1.5	1.5	0.7	0.8	1.0	0.7	0.9	1.4	0.6	1.1	0.0
Illnesses of mother	0.6	0.7	5.8	0.9	0.3	0.1	0.3	0.4	0.3	0.2	-0.1	1.5	0.4	0.3	0.4	-0.0	-0.2	2.4	1.5	1.1	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.9	15.6	0.8	-0.6	-1.3	-0.5	1.7	-0.6	-0.7	-0.1	1.3	-0.5	-0.6	0.1	-0.4	-1.0	4.0	-0.9	2.2	1.9
Standing height	0.6	5.7	38.6	1.9	0.5	-0.6	0.6	2.9	0.5	0.4	3.0	1.6	0.8	0.6	1.2	3.0	0.4	6.2	-0.3	2.7	4.6
Loud music exposure frequency	0.6	0.6	3.1	1.8	0.3	-0.0	0.6	1.4	0.3	0.3	-0.4	1.4	0.3	0.3	0.7	0.3	0.4	1.2	-0.3	0.9	0.7
Forced vital capacity (FVC), Best measure	0.6	2.4	21.3	1.1	-0.4	-1.1	-0.3	1.9	-0.5	-0.6	0.3	1.9	-0.3	-0.4	0.2	-0.3	-0.8	4.6	-0.4	2.2	2.1
Medication: Allopurinol	0.6	0.8	2.6	0.7	0.8	1.3	1.1	-0.5	0.9	0.9	0.6	0.2	0.9	0.8	0.6	0.9	1.2	-0.2	1.6	-0.2	1.1
Comparative height size at age 10	0.6	3.5	12.0	1.8	0.9	0.2	1.0	3.0	0.8	0.8	2.5	1.3	0.9	0.9	1.1	3.4	1.0	3.5	-1.0	1.4	3.0
Illnesses of siblings: Diabetes	0.6	0.8	3.7	-0.4	0.3	0.2	0.4	-1.6	0.4	0.4	0.6	-1.2	0.5	0.4	0.2	-1.4	0.3	-1.9	1.3	-0.9	-0.4
Commuting to job workplace: Walk	0.6	0.7	1.9	0.7	0.3	0.7	0.6	1.0	0.4	0.4	1.1	1.4	0.3	0.4	0.3	1.0	0.3	1.3	0.4	1.4	1.2
Back pain experienced in last month	0.6	0.9	4.8	0.0	0.8	0.6	0.7	1.9	0.8	0.8	0.2	-1.1	0.7	0.8	0.7	-0.2	1.0	0.7	-0.8	0.5	2.2
Breast cancer (self-reported)	0.6	0.7	2.4	-1.0	-0.8	-0.7	-0.8	-1.3	-0.8	-0.8	-1.6	-0.9	-0.7	-0.8	-0.7	0.1	-0.7	-0.2	-0.2	-1.1	0.0
Tinnitus: Yes, now most or all of the time	0.6	0.6	1.8	0.4	1.0	0.8	1.0	-0.2	1.0	1.0	0.7	-0.5	1.0	1.0	1.1	0.3	0.9	-1.3	0.7	-0.3	-0.1
Pain experienced in last month	0.6	1.1	3.8	-0.9	-1.2	-1.4	-1.3	-2.0	-1.3	-1.3	0.1	-0.1	-0.9	-1.2	-0.9	-0.4	-1.6	0.6	-0.2	-0.5	-0.3
Alcohol drinker status: Previous	0.6	0.7	1.5	0.0	1.1	0.7	1.0	0.2	1.1	1.1	0.9	-0.6	1.2	1.1	1.1	0.2	0.7	-0.5	0.6	0.4	0.2
Reaction Time	0.5	1.0	3.2	0.9	0.6	0.5	0.6	-0.1	0.5	0.5	-0.1	1.2	0.7	0.5	1.2	1.5	0.7	1.8	0.9	1.4	1.5
Fasting Glucose	0.5	0.5	1.8	0.8	0.7	0.6	0.7	0.5	0.7	0.7	1.4	0.3	0.9	0.7	0.7	1.2	0.4	0.5	0.4	0.2	0.8
Lung FVC	0.5	2.3	13.4	0.7	-0.6	-1.0	-0.4	2.3	-0.7	-0.7	-1.0	2.1	-0.7	-0.6	-0.1	-2.1	-0.8	3.7	-0.5	2.3	1.7
Ever had hysterectomy (womb removed)	0.5	0.6	3.3	-0.8	-0.4	-0.2	-0.5	-0.7	-0.4	-0.4	0.1	-1.8	-0.1	-0.3	-0.4	0.2	-0.2	-0.5	-1.3	-1.8	0.2
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	2.0	-0.5	0.3	0.3	0.1	-1.3	0.2	0.2	0.5	-1.1	0.4	0.3	-0.1	-1.4	-0.1	-1.4	1.2	-1.0	-0.7
Angina	0.5	0.7	4.2	0.6	0.2	0.8	0.3	-0.9	0.2	0.3	-0.5	-0.2	0.1	0.2	0.1	1.3	0.9	-2.0	0.5	-0.8	-1.4
Supplements: Zinc	0.5	0.5	2.9	0.7	0.2	-0.2	0.0	0.2	0.1	0.1	0.6	1.1	0.4	0.1	-0.1	1.2	-0.4	1.7	1.3	0.2	0.4
Townsend deprivation index at recruitment	0.5	0.7	1.8	-0.2	0.9	0.8	0.8	-0.7	0.9	0.9	-0.6	-1.2	1.0	0.9	0.7	0.4	1.1	-1.3	0.9	-0.3	0.6
Fed-up feelings	0.5	0.8	2.0	0.7	1.1	1.4	0.8	-0.2	1.0	1.0	0.5	-0.6	1.0	1.0	1.3	1.4	1.4	-0.7	0.6	0.4	0.2
High blood pressure	0.5	1.4	6.4	-1.9	-0.4	-0.4	-0.6	-1.5	-0.3	-0.3	-0.3	-2.5	-0.2	-0.3	-0.2	-0.8	-0.3	-2.5	-0.1	-2.1	-1.1
Sitting height	0.5	3.2	25.2	1.6	0.1	-0.8	0.1	1.7	0.1	0.1	2.4	1.3	0.4	0.2	0.7	2.3	-0.1	5.0	0.3	2.1	2.9
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.8	1.4	1.0	0.8	0.8	0.4	0.9	0.9	-0.7	0.8	0.8	0.9	1.1	0.7	1.0	-0.2	0.8	0.4	-0.0
Medication: Ramipril	0.5	0.6	2.5	-1.2	-0.4	-0.3	-0.6	-1.6	-0.4	-0.4	0.1	-1.6	-0.1	-0.4	-0.2	1.1	-0.5	-0.1	1.1	-0.8	0.0
Illnesses of siblings	0.5	0.6	2.1	1.3	0.5	0.4	0.5	1.1	0.5	0.4	0.4	1.5	0.5	0.5	0.4	0.6	0.2	1.4	-0.3	1.4	0.1
Medication: Paracetamol	0.5	0.8	2.6	0.1	0.8	1.0	0.7	-0.8	0.8	0.8	1.2	-0.8	0.9	0.8	0.4	-1.3	0.5	-1.6	1.4	-0.1	-0.2
Birth weight	0.5	1.1	10.1	0.3	-0.7	-0.7	-0.7	-0.6	-0.7	-0.7	-1.5	0.2	-1.0	-0.7	-0.7	-0.3	-0.1	-1.2	-0.2	-1.1	-3.2
Number of full brothers	0.5	0.7	2.5	0.0	0.7	1.0	0.7	-0.3	0.7	0.7	0.4	0.7	0.8	0.7	0.8	1.4	0.5	0.2	1.6	0.7	0.9
Angina (self-reported)	0.5	0.7	4.7	0.7	0.3	0.9	0.4	-0.7	0.3	0.4	-0.5	-0.2	0.2	0.3	0.2	1.2	1.0	-2.2	0.2	-0.7	-1.3
Migraine (self-reported)	0.5	0.6	2.5	0.7	0.9	1.1	1.0	0.4	0.9	1.0	1.6	0.3	0.8	0.9	0.7	-0.3	0.5	-0.4	0.8	0.7	0.2
Heart disease (mother)	0.5	0.6	1.6	0.4	1.0	1.1	0.9	0.4	0.9	0.9	-0.1	-0.8	1.0	0.9	0.7	0.1	1.0	-1.3	-0.4	-0.4	0.3
Hypertension (Self-reported)	0.5	1.4	5.8	-1.9	-0.4	-0.4	-0.6	-1.5	-0.4	-0.4	-0.5	-2.4	-0.3	-0.4	-0.2	-1.0	-0.4	-2.4	0.1	-2.0	-1.2
Diabetes diagnosed by doctor	0.5	0.9	1.5	1.0	1.1	1.2	1.1	0.6	1.0	1.1	1.2	0.4	1.0	1.0	0.6	0.9	1.1	-0.4	1.0	0.2	0.6
Friendships satisfaction	0.5	0.7	1.6	-0.4	-0.7	-1.3	-1.0	-1.1	-0.9	-0.9	-0.2	-1.1	-0.5	-0.8	-0.3	-0.7	-1.2	0.2	-1.0	-0.5	-0.4
Medication: Aspirin	0.5	0.6	3.6	0.3	0.6	0.8	0.6	-0.4	0.6	0.7	-0.7	0.6	0.6	0.7	0.7	0.8	0.6	-1.0	1.9	-0.2	-0.8
Vascular/heart problems diagnosed by doctor	0.5	1.5	7.7	1.6	0.4	0.3	0.5	1.8	0.3	0.3	0.6	2.1	0.1	0.3	0.2	0.3	0.2	2.8	-0.4	2.2	1.5
Cholesterol lowering medication	0.5	0.7	4.5	-0.2	0.7	1.1	0.7	0.0	0.7	0.8	0.9	-1.3	0.6	0.7	0.3	0.5	0.6	-2.1	-0.2	-1.1	-0.2
Bipolar Disorder (2018)	0.4	0.6	2.6	-0.4	-0.7	-0.7	-0.5	-1.6	-0.6	-0.6	-0.8	0.6	-0.3	-0.6	-0.7	-0.6	-1.0	0.6	1.6	0.0	-0.6
Bipolar Disorder or Schizophrenia	0.4	0.9	5.0	0.6	0.2	0.3	0.4	-0.1	0.3	0.3	0.6	1.4	0.6	0.3	0.4	0.6	-0.2	2.2	1.9	1.7	1.0
Intelligence (Savage-Jansen 2018)	0.4	1.1	6.8	-0.5	-1.1	-1.3	-1.2	1.2	-1.1	-1.1	0.1	0.4	-1.2	-1.1	-0.5	1.1	-0.4	-0.0	-2.6	-0.6	0.0
Alzheimer’s Disease (including proxy)	0.4	0.6	3.0	-1.0	0.2	0.2	-0.0	-0.1	0.2	0.2	0.1	-1.7	0.0	0.1	-0.0	-1.3	0.3	-1.7	-1.4	-0.6	0.6
Ulcerative Colitis (UC)	0.4	0.7	2.5	0.5	0.4	0.7	0.5	0.4	0.6	0.6	0.6	0.8	0.6	0.6	1.1	1.0	0.5	1.4	1.1	1.6	0.5
Major Depression (MDD)	0.4	0.5	1.1	0.5	1.1	0.6	0.9	0.3	1.0	1.0	0.4	-0.2	1.0	1.0	0.6	-0.2	0.5	-0.4	0.6	1.0	0.5
Type 2 Diabetes (T2D) (2012)	0.4	0.4	2.2	0.0	0.0	0.0	0.2	0.9	0.1	0.0	0.9	0.3	-0.0	0.0	-0.0	1.5	0.3	1.4	-0.1	0.8	1.0
Blood Eosinophil Count	0.4	2.7	6.1	1.0	2.0	2.4	2.2	0.4	2.1	2.1	0.5	0.1	1.9	2.0	1.1	-2.5	1.4	-1.5	2.0	0.6	-0.5
Cardiovascular Disease	0.4	1.4	7.2	-1.3	0.8	0.5	0.3	-0.9	0.7	0.7	0.3	-2.7	0.9	0.7	1.0	-1.1	0.2	-2.7	0.3	-1.7	-0.8
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.3	0.9	1.0	1.0	1.1	1.0	1.0	1.0	0.9	0.3	0.9	1.0	0.6	0.8	1.2	0.1	0.5	0.3	0.9
Chronotype (morning person)	0.4	1.0	1.9	1.0	1.4	1.2	1.3	1.0	1.3	1.3	0.5	-0.1	1.2	1.3	1.2	0.4	1.3	-0.9	-0.4	-0.4	0.3
Hand grip strength (left)	0.4	1.0	6.1	0.2	-0.9	-1.7	-0.8	0.4	-0.9	-0.9	-0.3	1.1	-0.7	-0.9	-0.5	-0.3	-1.4	2.5	0.0	1.0	0.4
Impedance of leg (right)	0.4	2.1	11.4	-0.2	0.6	0.1	0.7	1.7	0.6	0.6	2.2	0.1	0.8	0.7	0.8	0.5	-0.1	2.3	-1.6	2.6	3.4
Leg fat-free mass (left)	0.4	2.1	4.7	2.1	1.6	1.0	1.5	0.8	1.5	1.5	0.4	1.0	1.8	1.6	1.6	0.6	1.6	1.6	2.2	0.4	1.6
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	1.5	-1.2	-0.4	-0.0	-0.4	-0.8	-0.3	-0.3	-0.6	-1.2	-0.2	-0.3	-0.5	-1.0	-0.4	-0.7	-0.6	-1.0	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	4.6	-0.2	-0.8	-0.3	-0.5	-2.1	-0.7	-0.7	-1.7	0.4	-0.6	-0.7	-1.1	-0.2	-0.9	-1.0	0.7	-1.1	-0.5
Leg predicted mass (left)	0.4	2.2	4.8	2.2	1.7	1.0	1.5	0.9	1.6	1.6	0.4	1.0	1.8	1.6	1.6	0.5	1.6	1.6	2.2	0.4	1.7
Nervous feelings	0.4	0.7	1.9	1.1	0.7	0.8	0.6	1.4	0.8	0.7	1.0	0.8	0.8	0.8	0.9	-0.8	0.5	0.7	-0.1	0.8	1.2
Hair/balding pattern: Pattern 3	0.4	0.6	1.6	-0.4	-1.0	-1.3	-1.0	-0.2	-1.0	-1.0	-0.6	-0.7	-0.8	-0.9	-0.5	0.4	-0.8	1.1	-0.5	-0.6	-0.8
Medication: Cholesterol lowering	0.4	0.7	3.8	0.8	0.7	0.6	0.8	0.0	0.7	0.7	0.8	1.1	0.8	0.7	0.7	1.1	0.3	0.0	2.0	0.3	0.1
Prospective memory result	0.4	0.5	1.2	-0.3	-0.9	-0.9	-0.7	-0.4	-0.9	-0.9	-0.4	1.1	-1.1	-0.9	-0.9	0.2	-0.5	0.3	0.4	-0.3	-0.9
Exposure to tobacco smoke at home	0.4	0.5	1.8	0.6	0.9	0.3	0.7	0.4	0.8	0.8	-0.3	-0.9	1.1	0.9	0.7	0.2	0.7	0.2	-0.2	-0.0	1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.6	0.7	0.7	0.8	0.8	0.9	0.6	0.7	0.0	1.3	0.4	0.6	0.7	0.7	0.9	0.2	1.0	0.9	-0.6
Peak expiratory flow (PEF)	0.4	0.8	4.0	0.1	-0.3	-0.9	-0.3	1.6	-0.4	-0.4	-0.7	0.6	-0.5	-0.4	-0.3	-2.0	-0.9	1.4	-1.1	1.1	0.1
Hypothyroidism/myxoedema (self-reported)	0.4	0.9	2.3	-0.0	0.8	1.1	0.8	-1.1	0.8	0.9	0.1	-1.4	1.1	0.8	0.5	-0.1	1.2	-1.1	0.7	-0.8	1.5
Arm fat-free mass (right)	0.4	1.9	6.2	1.9	1.3	0.6	1.2	0.2	1.2	1.2	0.5	0.5	1.7	1.3	1.4	0.9	1.1	2.3	2.0	0.8	2.5
Neck or shoulder pain in last month	0.4	0.6	2.1	-0.3	0.8	0.8	0.7	-0.1	0.8	0.8	0.1	-1.4	0.8	0.8	0.1	-1.1	0.5	-1.4	-0.5	-0.5	0.6
Mean time to correctly identify matches	0.4	0.7	1.8	0.9	0.4	0.8	0.4	-0.1	0.4	0.4	-1.0	1.2	0.4	0.4	1.1	1.2	0.9	1.4	0.9	1.1	0.9
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	2.2	0.1	-0.3	-1.0	-0.4	0.5	-0.3	-0.3	0.5	0.6	-0.3	-0.3	0.1	1.5	-0.3	1.5	0.2	0.9	-0.5
Medication: Aspirin	0.4	0.6	3.1	0.3	0.7	0.7	0.6	-0.0	0.7	0.7	-0.8	0.6	0.7	0.7	0.8	0.9	0.5	-0.8	1.8	-0.0	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	5.5	0.8	0.5	-0.1	0.6	1.3	0.5	0.5	0.8	1.0	0.6	0.5	0.6	0.5	0.4	2.4	0.4	1.3	1.4
Handedness (chirality/laterality): Left-handed	0.4	0.4	2.9	-0.8	-0.1	-0.0	-0.2	-0.3	-0.3	-0.3	-0.6	-0.4	-0.4	-0.3	-0.4	-1.7	-0.5	-1.1	-0.6	-0.7	-0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	2.6	-0.2	0.4	0.1	0.2	0.1	0.4	0.4	0.7	0.0	0.5	0.4	0.5	-0.7	0.1	0.8	0.5	1.6	1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	2.2	-0.2	-1.2	-1.0	-1.0	-0.2	-1.1	-1.2	-1.4	0.8	-1.0	-1.1	-0.6	-0.1	-1.5	1.1	-0.1	0.5	-0.2
Medication: Paracetamol	0.4	0.6	2.1	0.7	0.8	1.2	0.8	-0.2	0.8	0.8	0.9	0.1	0.8	0.8	0.5	-0.3	0.8	-1.4	1.0	0.0	-0.3
Ever smoked	0.4	0.7	3.1	-0.9	0.4	0.0	0.2	-1.4	0.3	0.3	0.0	-1.8	0.5	0.3	-0.2	-1.5	-0.2	-1.1	0.8	-1.1	0.3
Basal metabolic rate	0.4	2.3	5.2	2.2	1.6	0.9	1.5	0.7	1.5	1.5	0.5	0.8	1.9	1.6	1.6	0.7	1.5	2.1	2.1	0.6	2.3
Number of operations (self-reported)	0.4	0.6	1.8	0.8	0.8	0.9	1.0	0.2	0.8	0.9	0.8	0.1	0.8	0.8	0.5	0.8	1.3	-1.0	0.2	0.0	0.6
Diastolic blood pressure, automated reading	0.4	1.3	7.7	-0.8	0.2	-0.1	-0.3	-1.2	0.2	0.1	0.8	-2.8	0.6	0.2	0.3	-0.0	0.2	-2.3	-1.2	-2.1	0.6
Neuroticism (Nagel 2018)	0.3	0.8	2.0	1.0	0.7	0.9	0.7	0.5	0.8	0.7	0.8	0.7	0.7	0.7	1.2	1.2	1.0	0.7	0.8	1.4	0.7
Bipolar Disorder (2011)	0.3	0.3	3.7	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.1	1.9	0.0	0.0	0.7	-0.7	0.3	0.0	0.0	0.0	0.0
Lupus	0.3	0.5	2.9	-0.6	-0.7	-0.3	-0.5	-0.9	-0.6	-0.6	-1.7	0.2	-0.7	-0.7	-0.8	-0.8	-0.4	-0.5	0.6	-0.7	0.4
Neuroticism (2016)	0.3	0.4	2.2	0.5	0.3	0.6	0.2	-0.5	0.1	0.2	-0.7	-0.4	0.2	0.1	0.6	1.5	0.8	-1.2	-0.7	-0.2	-0.2
Rheumatoid Arthritis	0.3	0.4	1.7	-0.5	0.0	-0.4	-0.2	-0.7	-0.0	-0.0	-0.4	-1.2	-0.1	-0.0	-0.4	-0.7	-0.3	-1.1	0.6	-1.0	-1.3
Schizophrenia (2014)	0.3	0.7	6.3	0.2	-0.4	-0.4	-0.2	-0.2	-0.3	-0.3	0.1	0.5	-0.1	-0.3	0.1	0.7	-0.7	2.5	0.9	1.3	1.4
Height	0.3	6.1	52.1	1.1	-1.1	-1.7	-0.7	1.8	-1.0	-1.1	1.6	2.6	-0.6	-0.9	0.0	3.1	-1.1	7.2	0.3	2.3	4.4
Allergy or Eczema	0.3	0.9	3.5	0.6	-0.2	-0.3	0.1	0.5	-0.2	-0.2	-0.2	1.8	-0.4	-0.2	0.1	1.7	-0.4	1.9	1.2	1.9	-0.4
Average weekly spirits intake	0.3	0.4	2.7	-0.6	0.5	0.2	0.1	-0.2	0.4	0.4	0.1	-1.6	0.6	0.4	0.6	-1.1	-0.2	0.2	0.3	-0.0	0.8
Sensitivity / hurt feelings	0.3	0.5	1.7	0.9	0.2	0.5	0.4	1.1	0.2	0.2	-0.8	0.9	0.1	0.2	0.7	-0.1	0.6	1.3	-0.6	1.0	0.5
Relative age of first facial hair	0.3	0.5	1.8	-0.2	-0.7	-0.7	-0.6	-0.1	-0.7	-0.7	-1.0	0.7	-0.5	-0.7	-0.6	-1.1	-0.7	1.3	-1.1	-0.2	0.5
Vitamin and mineral supplements	0.3	0.4	2.9	-0.4	0.1	0.4	0.1	-0.8	0.1	0.1	0.0	-0.9	-0.1	0.0	-0.1	-1.1	0.2	-1.7	-0.1	-0.8	-0.4
Pack years adult smoking proportion	0.3	0.4	2.9	0.0	0.1	0.1	0.3	-0.3	0.1	0.2	-0.7	0.3	-0.0	0.1	-0.2	0.7	0.4	-1.4	0.5	-1.0	-1.7
Medication: Levothyroxine sodium	0.3	0.5	2.8	-0.5	0.3	0.7	0.2	-1.4	0.3	0.3	-0.0	-1.7	0.5	0.3	-0.1	-0.4	0.3	-1.2	0.6	-1.2	0.2
Chronic bronchitis/emphysema (father)	0.3	0.4	1.0	-0.5	-0.6	-0.4	-0.6	-1.0	-0.6	-0.6	-1.0	-0.4	-0.5	-0.6	-0.6	-0.9	-0.5	-0.2	-0.3	-0.5	0.6
Impedance of leg (left)	0.3	1.4	6.3	-0.3	0.4	0.0	0.5	1.4	0.5	0.4	1.7	0.0	0.5	0.5	0.6	1.0	-0.0	1.7	-1.5	2.3	2.5
Past tobacco smoking	0.3	0.6	2.9	0.4	-0.7	-0.5	-0.5	1.0	-0.7	-0.7	-0.9	1.7	-0.8	-0.7	-0.3	0.4	-0.4	1.0	-0.6	0.7	-0.6
Alcohol usually taken with meals	0.3	0.5	1.7	0.5	-0.7	-0.5	-0.6	0.5	-0.7	-0.7	0.1	0.8	-0.8	-0.7	-0.4	1.2	-0.4	1.3	-0.9	0.6	0.7
Qualifications: None of the above	0.3	0.7	2.6	-0.2	0.8	0.9	0.8	-0.4	0.8	0.9	-0.9	-1.2	1.0	0.9	0.6	-0.6	1.1	-1.6	0.5	-0.9	0.2
Heart attack	0.3	0.4	2.2	0.4	0.3	0.4	0.5	-1.0	0.3	0.3	-0.2	0.8	0.3	0.3	0.2	0.7	0.4	-1.1	1.5	-0.5	0.0
Trunk fat-free mass	0.3	1.5	10.8	1.5	0.6	-0.2	0.5	0.5	0.5	0.5	0.4	0.6	1.0	0.6	0.9	0.4	0.4	3.3	1.4	0.7	2.7
Father’s age at death	0.3	0.4	3.0	0.4	0.0	0.2	0.0	0.2	-0.0	-0.0	0.1	0.5	-0.1	0.0	0.1	-0.5	0.1	1.7	0.3	1.1	1.1
Impedance of arm (left)	0.3	1.6	7.7	0.7	0.9	0.9	1.0	2.8	0.9	0.9	2.1	1.1	0.5	0.9	0.9	1.5	1.0	0.7	-1.4	1.6	0.6
Hair/balding pattern: Pattern 4	0.3	0.8	3.9	1.1	0.3	0.0	0.4	0.2	0.3	0.3	0.6	1.4	0.5	0.4	0.3	0.7	0.4	2.0	1.5	1.0	1.5
Glaucoma (self-reported)	0.3	0.3	1.0	0.3	0.6	0.1	0.7	0.8	0.6	0.6	0.5	0.1	0.6	0.7	0.6	-0.2	0.7	0.5	-0.4	0.1	1.0
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.8	0.4	0.9	0.7	0.6	0.5	0.8	0.8	0.0	-0.7	0.8	0.8	0.9	0.0	0.6	-0.5	-0.6	-0.6	0.2
Comparative body size at age 10	0.3	0.8	3.9	-0.4	-0.4	-0.2	-0.2	-2.0	-0.3	-0.3	-1.8	-0.4	-0.3	-0.3	-0.6	-1.6	-0.0	-1.6	0.3	-1.0	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	2.6	0.3	0.1	0.2	0.0	-0.2	0.1	0.1	0.7	-0.4	0.4	0.1	0.3	1.6	-0.2	0.7	0.6	1.0	0.8
Arm predicted mass (right)	0.3	1.7	5.7	1.7	1.2	0.5	1.1	0.3	1.2	1.2	0.6	0.2	1.6	1.2	1.4	0.8	1.1	2.1	1.7	0.6	2.4
Suffer from ‘nerves’	0.3	0.5	2.9	0.4	0.5	0.6	0.4	0.7	0.5	0.5	0.3	-0.1	0.6	0.5	0.7	0.6	0.6	0.4	-0.7	0.7	1.7
Had major operations	0.3	0.3	1.0	-0.4	-0.5	-0.5	-0.4	-0.4	-0.6	-0.5	-0.2	0.5	-0.6	-0.6	-0.8	-0.6	-1.0	-0.1	0.7	0.0	-0.7
Smoking status: Previous	0.3	0.4	2.8	-0.7	0.1	0.1	-0.1	-1.2	0.1	0.1	0.8	-1.7	0.3	0.1	-0.1	-0.3	-0.3	-0.6	0.2	-0.7	0.6
Whole body fat-free mass	0.3	1.5	6.4	1.8	1.1	0.3	0.9	0.6	1.0	0.9	0.4	0.7	1.3	1.0	1.2	0.6	0.9	2.5	1.7	0.5	2.2
Leg fat-free mass (right)	0.3	1.5	4.7	2.0	1.3	0.7	1.2	0.6	1.3	1.2	0.2	1.0	1.4	1.3	1.3	0.8	1.4	1.3	2.2	0.1	1.0
Loneliness, isolation	0.3	0.4	1.5	1.0	0.5	0.6	0.4	-0.2	0.4	0.5	-0.1	0.8	0.6	0.5	0.7	1.2	0.7	0.4	0.9	0.5	0.3
Qualifications: nursing, teaching	0.3	0.4	1.8	0.0	-0.6	-1.0	-0.4	0.0	-0.6	-0.6	-0.8	1.4	-0.7	-0.6	-0.6	-0.6	-0.6	-0.2	0.4	0.1	-1.0
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	0.8	-0.9	-0.5	-0.7	-0.8	-0.7	-0.7	-0.7	-0.4	-0.6	-0.5	-0.6	-0.7	-0.8	-0.8	0.4	-0.8	-0.2	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	1.7	0.0	0.4	0.3	0.4	1.1	0.3	0.3	0.1	-0.9	0.2	0.3	-0.2	-1.3	0.1	0.0	-0.8	0.2	0.4
Whole body water mass	0.3	1.6	6.4	1.9	1.1	0.3	0.9	0.6	1.0	1.0	0.4	0.7	1.4	1.0	1.2	0.6	1.0	2.5	1.8	0.5	2.2
Leg predicted mass (right)	0.3	1.6	4.8	2.0	1.4	0.7	1.2	0.6	1.3	1.3	0.2	1.1	1.5	1.3	1.3	0.8	1.4	1.4	2.2	0.2	1.0
Average weekly champagne plus white wine intake	0.3	0.5	3.1	0.5	0.3	0.5	0.3	1.0	0.2	0.2	1.8	0.7	0.1	0.2	0.2	-0.0	0.2	1.1	-0.9	0.5	1.0
Fractured/broken bones in last 5 years	0.3	0.4	0.9	-0.4	-0.6	-0.8	-0.7	-0.1	-0.7	-0.6	-0.8	-0.7	-0.6	-0.7	-0.6	0.7	-0.9	-0.1	-0.9	-0.6	-0.2
Heart attack/myocardial infarction (self-reported)	0.3	0.4	2.0	0.2	0.1	0.3	0.4	-1.1	0.2	0.2	-0.3	0.6	0.2	0.2	0.0	0.6	0.3	-1.2	1.4	-0.7	-0.1
Heart disease (siblings)	0.3	0.4	2.0	-0.3	-0.6	-0.6	-0.6	-0.7	-0.6	-0.6	-1.4	-0.1	-0.6	-0.6	-0.4	0.0	-0.2	-0.5	-0.2	-1.3	-0.0
Pack years of smoking	0.3	0.5	3.0	-0.1	-0.3	-0.1	-0.0	-0.5	-0.2	-0.2	-0.7	0.2	-0.4	-0.3	-0.5	1.0	0.2	-1.4	0.3	-1.3	-1.7
Impedance of whole body	0.3	1.3	4.6	-0.0	0.5	0.3	0.5	2.1	0.5	0.5	2.1	0.4	0.3	0.5	0.6	1.5	0.3	1.2	-1.7	1.9	1.6
Arm predicted mass (left)	0.3	1.6	5.8	1.7	1.2	0.6	1.1	0.2	1.2	1.2	0.4	0.4	1.6	1.2	1.2	0.6	1.1	1.9	1.8	0.4	2.4
HDL Cholesterol	0.2	0.3	1.4	0.1	0.4	0.9	0.2	-0.4	0.3	0.3	1.2	-1.0	0.3	0.3	0.2	0.2	0.4	-0.7	0.1	-0.4	0.1
Primary Biliary Cirrhosis	0.2	0.3	2.0	-0.6	0.3	-0.1	0.3	0.4	0.4	0.4	1.4	-0.4	0.5	0.4	-0.2	-0.8	-0.1	0.1	-0.4	0.3	0.7
Triglycerides	0.2	0.3	0.7	-0.8	-0.3	-0.6	-0.5	-0.7	-0.4	-0.4	-0.3	-0.8	-0.2	-0.3	-0.3	0.5	0.2	-0.3	-0.4	-0.7	-0.7
Hypothyroidism (self reported)	0.2	0.4	1.8	-0.2	0.4	0.3	0.3	-1.0	0.4	0.4	-0.6	-1.3	0.6	0.4	0.4	0.3	0.9	-0.6	0.2	-0.5	1.3
Hearing difficulty/problems: Yes	0.2	0.3	1.4	-0.1	0.7	0.7	0.4	0.3	0.7	0.6	1.2	0.1	0.7	0.7	0.8	-0.4	0.4	-0.1	0.3	0.5	-0.5
Diabetes (father)	0.2	0.3	0.9	0.3	0.6	0.4	0.6	0.3	0.7	0.7	0.9	0.1	0.7	0.7	0.6	0.2	0.6	-0.3	0.4	-0.2	-0.4
Average weekly fortified wine intake	0.2	0.2	0.7	-0.8	-0.4	-0.6	-0.6	-0.4	-0.4	-0.5	-0.7	-0.4	-0.3	-0.4	-0.2	-0.2	-0.4	0.5	-0.1	-0.2	0.7
Age when periods started (menarche)	0.2	0.4	0.9	0.2	0.8	0.5	0.6	0.1	0.8	0.7	-0.0	-1.0	0.8	0.8	0.8	0.1	0.8	-0.8	-0.1	-0.1	0.2
Serious illness, injury or assault to yourself	0.2	0.3	0.5	0.1	0.6	0.4	0.6	0.6	0.6	0.6	0.2	-0.7	0.7	0.6	0.5	-0.6	0.6	-0.4	0.7	-0.0	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	3.6	0.1	-0.5	-0.1	-0.2	-1.9	-0.4	-0.4	-1.2	0.7	-0.2	-0.4	-0.7	-0.1	-0.6	-0.3	1.4	-0.8	-0.3
Impedance of arm (right)	0.2	1.1	6.5	0.3	0.5	0.4	0.6	2.5	0.5	0.5	1.8	0.9	0.2	0.5	0.5	1.0	0.5	1.0	-1.4	1.4	0.8
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.1	-0.7	-0.5	-0.9	-0.9	-0.4	-0.7	-0.7	0.2	-0.6	-0.4	-0.7	-0.5	-0.8	-1.0	0.6	-0.3	-0.5	-0.4
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	1.0	0.3	0.5	0.7	0.5	0.4	0.5	0.6	0.7	-0.5	0.5	0.5	0.5	-0.4	0.2	0.1	0.3	0.5	1.0
Trunk predicted mass	0.2	1.4	10.9	1.4	0.5	-0.3	0.4	0.4	0.4	0.4	0.4	0.6	0.9	0.5	0.8	0.4	0.3	3.3	1.3	0.7	2.6
Breastfed as a baby	0.2	0.2	0.8	-0.6	-0.3	-0.1	-0.2	-0.7	-0.2	-0.2	-0.2	0.4	-0.3	-0.2	-0.5	-0.9	-0.5	0.0	0.7	-0.0	-0.8
Pulse wave reflection index	0.2	0.3	2.5	0.3	0.1	-0.1	0.1	0.3	-0.0	-0.0	-0.4	0.7	0.1	0.0	0.1	0.3	-0.1	1.6	1.0	0.6	0.2
Exposure to tobacco smoke outside home	0.2	0.2	1.4	-0.2	0.3	-0.4	0.3	0.2	0.2	0.2	-1.2	-1.0	0.3	0.3	0.2	-0.4	0.2	0.0	-0.1	-0.1	0.8
Number of children fathered	0.2	0.2	0.7	-0.2	-0.3	-0.6	-0.5	-0.2	-0.3	-0.4	-0.7	-0.2	-0.2	-0.3	-0.0	0.8	-0.5	0.5	0.6	-0.7	-0.8
Medication: Ibuprofen	0.2	0.2	1.1	0.3	0.3	0.7	0.3	0.4	0.3	0.3	-0.0	-0.5	0.3	0.3	0.4	-0.7	0.2	0.2	-0.2	0.6	1.0
Medication: Seretide 50 evohaler	0.2	0.2	0.8	-0.1	0.5	-0.1	0.2	0.4	0.3	0.3	0.2	-0.9	0.5	0.4	0.6	-0.6	0.2	0.6	0.2	-0.3	0.4
Pulse rate, automated reading	0.2	0.6	2.8	-0.1	-0.5	-0.4	-0.6	-1.3	-0.6	-0.6	-0.7	-0.4	-0.6	-0.6	-0.3	0.2	-0.0	-1.6	-0.4	-1.7	-1.1
Number of full sisters	0.2	0.2	1.5	-0.2	0.1	-0.1	0.0	-0.8	0.1	0.1	-0.3	-0.9	0.3	0.1	-0.1	-1.2	-0.3	-0.1	0.7	-0.2	0.5
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.7	0.7	0.4	0.4	0.5	0.8	0.4	0.4	-0.2	0.6	0.3	0.4	0.4	-0.1	0.8	-0.3	-0.1	0.3	-0.1
Knee pain experienced in last month	0.2	0.3	1.0	0.3	0.5	0.7	0.6	0.8	0.6	0.6	-0.8	-0.1	0.4	0.6	0.4	0.0	0.8	-1.0	0.1	-0.5	0.0
Commuting to job workplace: Public transport	0.2	0.2	1.1	0.1	-0.1	0.2	-0.0	0.5	-0.2	-0.2	-0.2	0.7	-0.2	-0.2	-0.4	-1.0	-0.1	1.1	-0.3	0.3	0.4
Eye problems/disorders: Glaucoma	0.2	0.2	0.7	-0.5	-0.3	-0.6	-0.1	-0.5	-0.3	-0.2	-0.6	-0.4	-0.4	-0.3	-0.5	-0.8	-0.1	-0.9	-0.5	-0.5	-0.0
Alcohol drinker status: Never	0.2	0.2	2.3	-0.2	-0.3	-0.2	0.0	0.1	-0.1	-0.1	0.2	-0.3	-0.2	-0.1	-0.1	1.5	0.3	-0.3	-1.0	-0.0	0.7
Arm fat-free mass (left)	0.2	1.3	5.0	1.5	1.1	0.5	1.0	0.0	1.0	1.0	0.3	0.0	1.5	1.1	1.0	0.4	1.0	1.7	1.6	0.2	2.2
Alzheimer’s Disease (in mother)	0.1	0.2	0.7	-0.3	0.5	0.2	0.3	0.1	0.4	0.4	0.2	-0.4	0.4	0.3	0.2	-0.2	0.1	-0.3	-0.7	0.3	0.9
Tanning	0.1	1.3	2.9	-1.1	-1.4	-1.4	-1.3	-1.7	-1.4	-1.4	-0.8	0.9	-1.3	-1.4	-1.2	-0.3	-1.5	0.5	0.8	0.2	-0.9
Hand grip strength (right)	0.1	0.3	1.4	-0.1	-0.4	-1.2	-0.5	0.3	-0.3	-0.4	0.6	-0.1	-0.2	-0.3	-0.0	-0.5	-0.6	1.1	-0.4	0.8	0.6
Hearing difficulty/problems with background noise	0.1	0.2	0.6	0.3	0.6	0.6	0.3	0.1	0.6	0.5	0.4	-0.2	0.6	0.6	0.8	-0.6	0.3	-0.3	0.3	0.4	-0.1
Number of live births	0.1	0.1	0.4	0.2	0.1	0.4	0.2	0.4	0.1	0.2	-0.7	-0.2	0.0	0.1	0.1	0.6	0.2	-0.6	-0.2	0.0	-0.3
Pulse rate	0.1	0.2	2.3	0.4	0.1	0.1	-0.1	-0.7	0.1	0.1	0.9	0.2	0.1	0.1	0.3	1.5	0.3	-0.1	0.4	-0.0	-0.2
Medication: Amlodipine	0.1	0.1	0.5	-0.1	0.0	-0.0	-0.1	0.1	0.0	0.0	0.2	-0.4	0.1	0.1	0.2	0.7	0.1	-0.0	-0.1	-0.4	-0.7
Chronic bronchitis/emphysema (mother)	0.1	0.2	0.8	-0.2	-0.3	-0.1	-0.2	-0.4	-0.2	-0.2	-0.2	0.0	-0.2	-0.2	-0.4	0.7	-0.1	-0.5	-0.7	-0.9	-0.2
High blood pressure (siblings)	0.1	0.2	0.7	-0.8	-0.3	-0.2	-0.3	-0.5	-0.2	-0.2	-0.1	-0.7	-0.2	-0.2	-0.2	-0.7	-0.2	-0.2	0.5	-0.6	0.2
Worry too long after embarrassment	0.1	0.2	1.2	0.4	-0.0	0.2	0.0	0.3	0.1	0.1	-0.1	0.1	0.1	0.1	0.3	0.7	0.3	0.7	-0.5	1.0	1.1
Eye problems/disorders: None of the above	0.1	0.2	1.2	-0.1	-0.3	0.0	-0.4	0.1	-0.4	-0.4	-0.7	-0.2	-0.5	-0.4	-0.0	-1.1	-0.3	0.3	-0.1	-0.2	-0.3
Medication: Blood pressure	0.1	0.2	1.0	-0.5	-0.2	-0.2	-0.1	-0.7	-0.2	-0.2	-0.2	-0.0	0.0	-0.2	-0.1	0.2	-0.3	-0.4	1.0	-0.7	-0.5
Eye problems/disorders: Cataract	0.1	0.2	0.5	-0.3	-0.3	-0.6	-0.4	0.2	-0.3	-0.3	0.4	-0.1	-0.1	-0.3	-0.3	0.5	-0.4	0.7	-0.6	0.4	-0.1
Mineral and other dietary supplements	0.1	0.1	0.4	-0.2	0.3	0.4	0.2	-0.1	0.3	0.3	0.4	-0.1	0.4	0.3	0.4	-0.2	0.2	-0.6	-0.1	0.1	0.5
Medication: Gliclazide	0.1	0.1	0.7	-0.1	-0.1	-0.2	-0.1	-0.6	-0.2	-0.1	-0.0	0.3	-0.1	-0.2	-0.4	0.1	-0.2	-0.8	0.7	-0.2	-0.0
Supplements: Fish oil (including cod liver oil)	0.1	0.2	1.3	-0.1	-0.1	-0.4	-0.2	0.8	-0.2	-0.2	-0.4	0.2	-0.2	-0.2	-0.2	-0.2	-0.3	1.2	-0.2	0.3	-0.0
Irritability	0.1	0.2	1.4	0.4	-0.1	0.1	-0.0	-0.3	-0.1	-0.1	-0.2	-0.1	-0.1	-0.1	0.1	1.2	0.2	-1.1	-0.7	-0.2	-0.6
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.5	-0.1	0.0	0.6	0.2	0.6	0.1	0.1	0.4	-0.2	0.1	0.1	-0.3	-0.2	0.1	0.1	-0.0	0.2	0.7
Age started oral contraceptive pill	0.1	0.2	1.0	0.3	0.4	0.6	0.3	-0.2	0.3	0.3	1.0	0.0	0.5	0.3	0.1	0.3	0.5	-0.6	0.2	-0.4	0.2
Hair Pigment	0.0	1.1	2.8	0.3	0.9	0.5	0.7	-0.9	0.7	0.7	1.7	0.5	1.1	0.8	1.2	1.5	0.4	1.4	1.4	1.5	1.2

Hub : Genes

SEMA4A

Models

Trait associations