TWAS hub - MTX1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Coronary	0.2420	0.0940	4.7e-03	-0.006	NA	-0.002	NA	0.000	5.6e-01	NA	3.7e-01	NA	3.3e-01
2	YFS	Blood	0.0577	0.0175	4.3e-08	0.017	0.031	0.024	0.03	0.024	2.1e-06	1.9e-10	1.8e-08	3.3e-10	1.8e-08

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Medication: Allopurinol	11.0	14.7	23.1	-2.5	-4.8
Blood Red Count	10.7	103.0	144.0	-7.9	12.0
Gout (self-reported)	9.0	12.3	16.9	-2.8	-4.1
Hearing difficulty/problems with background noise	7.9	12.6	20.0	-2.3	4.5
Pain type(s) experienced in last month: Hip pain	6.8	8.5	16.9	-4.1	0.4
Worry too long after embarrassment	6.1	10.2	12.9	2.8	3.6
Neuroticism score	6.0	12.5	17.2	2.8	4.1
Miserableness	5.5	9.5	12.0	2.6	3.5
Hearing difficulty/problems: Yes	5.2	8.0	12.8	-1.8	3.6
Breast Cancer	4.9	11.7	23.2	-0.4	-4.8
Medication: Atorvastatin	4.9	6.0	9.4	-1.6	3.1
Illnesses of father: High blood pressure	4.8	5.9	11.0	3.3	0.9
Impedance of leg (left)	4.7	23.0	43.8	1.5	6.6
Pulse wave reflection index	4.6	5.6	7.2	-2.0	2.7
Irritable Bowel Disease (IBD)	4.5	10.7	21.2	-0.4	4.6
Sensitivity / hurt feelings	4.5	7.7	10.7	2.2	3.3
Frequency of depressed mood in last 2 weeks	4.4	6.2	10.4	1.4	3.2
Impedance of leg (right)	4.4	21.4	39.7	1.8	6.3
Guilty feelings	4.4	6.7	11.4	1.4	3.4
Ever smoked	4.4	7.6	11.0	-2.1	3.3
Neuroticism	4.3	10.3	17.1	1.9	4.1
Mouth/teeth dental problems: Dentures	4.3	7.3	11.5	-1.8	3.4
Smoking status: Previous	4.3	6.5	11.5	-1.2	3.4
Crohns Disease (2017)	4.2	9.2	18.3	0.1	4.3
Past tobacco smoking	4.2	7.7	14.4	1.0	-3.8
Mood swings	4.2	7.5	9.8	2.3	3.1
Tense / ‘highly strung’	4.1	6.8	8.9	2.2	3.0
Neuroticism (Nagel 2018)	4.0	9.4	10.9	2.8	3.3
Emphysema/chronic bronchitis	3.9	4.4	6.6	1.5	2.6
Irritability	3.9	6.6	9.5	3.1	1.9
Coronary Artery Disease (CAD)	3.7	4.4	8.8	3.0	-0.2
Hayfever, allergic rhinitis or eczema	3.5	7.7	14.8	-0.8	3.9
Hayfever/allergic rhinitis (self-reported)	3.5	4.6	5.6	-1.9	2.4
Risk taking	3.4	5.0	8.9	-1.0	3.0
Allergy	3.3	7.6	15.0	0.6	-3.9
Medication: Ramipril	3.3	4.2	8.2	-0.4	2.9
Breastfed as a baby	3.2	3.9	7.2	-2.7	0.8
Birth weight of first child	3.2	5.9	11.5	-0.5	-3.4
Allergy or Eczema	3.1	8.2	13.8	-1.6	3.7
Frequency of unenthusiasm / disinterest in last 2 weeks	3.1	4.1	8.2	0.0	2.9
Mouth/teeth dental problems	3.1	4.8	9.4	0.5	-3.1
Depressed Affect (Nagel 2018)	3.0	6.2	10.4	1.5	3.2
Bipolar Disorder or Schizophrenia	2.9	7.1	7.3	2.7	2.6
Depression (Nagel 2018)	2.9	4.4	8.1	0.9	2.8
HbA1C	2.9	3.2	3.3	1.8	1.8
Average weekly fortified wine intake	2.9	3.3	4.4	1.5	-2.1
High blood pressure (mother)	2.9	4.1	4.3	2.1	-2.0
Happiness	2.9	3.6	4.2	1.7	2.0
Birth weight	2.9	6.3	12.5	-0.3	-3.5
Wheeze or whistling in the chest in last year	2.9	5.1	10.2	0.0	3.2
Prostate Cancer	2.8	3.9	4.1	2.0	1.9
Frequency of tenseness / restlessness in last 2 weeks	2.8	4.4	4.8	2.0	2.2
Number of children fathered	2.8	3.2	6.1	-2.5	-0.6
Neuroticism (2016)	2.7	4.0	4.4	2.1	1.9
Heel bone mineral density (BMD) T-score, automated (left)	2.6	5.9	8.7	-3.0	-1.8
Hearing aid user	2.6	2.9	5.0	-2.2	0.9
Primary Biliary Cirrhosis	2.5	3.5	7.0	2.6	-0.2
Waist Hip Ratio (WHR)	2.5	11.3	17.9	-2.1	4.2
Tinnitus: Yes, now most or all of the time	2.5	2.9	4.0	-2.0	1.3
Schizophrenia (2014)	2.4	5.3	8.4	2.9	1.5
Respiratory disease	2.4	5.3	10.6	-0.0	3.2
Illnesses of mother	2.4	2.9	3.4	-1.6	1.9
Leg predicted mass (right)	2.4	12.7	24.6	-0.9	-5.0
Bipolar Disorder (2018)	2.3	3.6	5.5	1.3	2.3
Leg fat-free mass (left)	2.3	12.1	23.7	-0.7	-4.9
Leg predicted mass (left)	2.3	12.2	23.7	-0.8	-4.9
Chest pain or discomfort	2.3	3.3	6.1	-0.8	2.5
Leg fat-free mass (right)	2.3	12.5	24.1	-0.9	-4.9
BMI	2.2	12.6	17.1	-2.9	-4.1
Heel bone mineral density (BMD) T-score, automated (right)	2.2	5.1	9.7	-3.1	-0.6
Suffer from ‘nerves’	2.2	3.5	4.8	1.5	2.2
Arm fat mass (left)	2.2	9.2	18.2	-0.4	-4.3
Impedance of whole body	2.2	11.0	14.6	2.7	3.8
Ulcerative Colitis (UC)	2.1	4.0	8.1	-0.0	2.8
Lung FVC	2.1	10.9	21.8	-0.1	-4.7
Fed-up feelings	2.1	3.8	4.3	1.8	2.1
Arm fat percentage (right)	2.1	8.3	16.4	0.5	-4.0
Arm fat mass (right)	2.1	8.7	17.3	-0.4	-4.2
Age at First Birth	2.0	3.0	4.9	1.0	-2.2
Diverticular disease/diverticulitis (self-reported)	2.0	2.4	4.5	-0.5	-2.1
Hair/balding pattern: Pattern 4	2.0	4.9	9.0	-0.9	-3.0
Had major operations	2.0	2.3	3.8	-1.9	0.9
Family relationship satisfaction	2.0	2.4	3.0	1.4	1.7
Arm fat percentage (left)	2.0	7.8	15.7	0.1	-4.0
Ever had stillbirth, spontaneous miscarriage or termination	2.0	2.2	4.4	0.0	2.1
Age started oral contraceptive pill	2.0	2.5	4.6	0.7	-2.1
Schizophrenia (2018)	1.9	3.9	5.8	2.4	1.4
Body mass index (BMI)	1.9	8.2	14.5	-1.4	-3.8
Asthma	1.9	3.7	7.2	-0.5	2.7
Pulse wave peak to peak time	1.9	2.3	3.5	1.0	-1.9
Schizophrenia vs Biploar Disorder	1.8	2.4	3.5	1.9	-1.2
Alzheimer’s Disease (in mother)	1.8	2.1	4.2	0.1	2.1
Illnesses of siblings	1.8	2.5	5.0	0.3	2.2
Frequency of tiredness / lethargy in last 2 weeks	1.8	3.0	5.7	0.6	2.4
Pulse wave Arterial Stiffness index	1.8	2.1	3.3	-1.0	1.8
Hypothyroidism/myxoedema (self-reported)	1.8	3.6	5.3	-1.4	-2.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.8	2.4	4.5	0.5	2.1
Asthma (self-reported)	1.8	3.6	7.2	0.0	2.7
Severe depression (siblings)	1.7	1.9	3.6	0.4	1.9
Weight	1.7	8.4	15.0	-1.3	-3.9
Worrier / anxious feelings	1.7	3.3	5.8	2.4	0.9
Qualifications: A levels/AS levels or equivalent	1.7	3.8	5.4	1.5	2.3
Unable to work because of sickness or disability	1.7	2.2	4.4	2.1	0.0
Worry (Nagel 2018)	1.6	3.5	5.2	2.3	1.3
Lupus	1.6	2.4	4.7	-2.2	0.1
Triglycerides	1.6	2.7	5.4	-0.1	2.3
Had menopause	1.6	2.0	4.0	-0.1	-2.0
High blood pressure (siblings)	1.6	2.4	4.4	0.6	-2.1
Medication: Gliclazide	1.6	1.8	2.2	1.5	1.2
Number of self-reported non-cancer illnesses	1.6	2.7	3.2	-1.8	1.5
Commuting to job workplace: Public transport	1.6	1.9	2.2	1.5	-1.3
LDL Cholesterol	1.5	2.4	4.5	0.6	2.1
Heel T-Score	1.5	12.3	16.3	-4.0	-2.9
Hand grip strength (right)	1.5	4.0	7.3	-2.7	-0.8
Multivitamins +/- minerals	1.5	1.9	3.5	-0.4	-1.9
Trunk fat mass	1.5	6.3	12.4	-0.5	-3.5
Impedance of arm (right)	1.5	7.1	13.8	3.7	0.5
Loud music exposure frequency	1.5	1.6	3.1	1.8	-0.3
Whole body fat mass	1.5	6.1	11.5	-0.8	-3.4
Osteoporosis (self-reported)	1.5	1.9	3.0	1.7	0.9
Basal metabolic rate	1.5	8.1	14.7	-1.3	-3.8
Crohns Disease (2012)	1.4	2.3	4.6	0.2	2.1
Type 2 Diabetes (T2D) (2012)	1.4	1.6	2.1	-1.0	1.5
Hand grip strength (left)	1.4	3.8	7.5	-2.7	-0.2
Pack years adult smoking proportion	1.4	2.1	3.9	0.6	-2.0
Stomach or abdominal pain in last month	1.4	1.8	3.3	-0.5	1.8
Alcohol usually taken with meals	1.4	2.3	2.4	1.6	1.5
Whole body water mass	1.4	7.9	13.8	-1.4	-3.7
Ever taken oral contraceptive pill	1.4	1.6	1.7	1.3	1.2
Eye problems/disorders: Glaucoma	1.4	1.7	3.3	-1.8	-0.2
Alcohol drinker status: Previous	1.4	1.6	1.7	-1.3	1.2
Body Mass Index (BMI) (2010)	1.3	1.8	2.5	-1.6	-1.1
Smoking Status	1.3	3.1	5.9	-0.5	2.4
Tanning	1.3	16.1	23.8	-2.9	4.9
Hip circumference	1.3	5.5	10.9	-0.4	-3.3
Glaucoma (self-reported)	1.3	1.5	2.8	-1.7	0.5
Medication: Blood pressure	1.3	2.2	4.4	-0.4	2.1
Illnesses of father: Heart disease	1.3	1.8	3.6	0.3	-1.9
Whole body fat-free mass	1.3	7.6	13.3	-1.4	-3.6
Loneliness, isolation	1.3	1.8	3.5	0.3	1.9
Alzheimer’s Disease (including proxy)	1.2	1.7	3.2	0.5	1.8
Fasting Glucose	1.2	1.4	1.7	-1.1	1.3
Blood Platelet Count	1.2	13.8	26.5	1.0	5.2
Average weekly spirits intake	1.2	1.5	2.0	-1.0	-1.4
Number of live births	1.2	1.7	3.4	-0.2	1.8
Lung cancer (father)	1.2	1.5	2.2	-1.5	-0.8
Ever highly irritable/argumentative for 2 days	1.2	1.4	2.1	0.9	1.5
Heart disease (mother)	1.2	1.4	2.6	-0.5	-1.6
Pulse rate, automated reading	1.2	4.0	5.9	2.4	-1.4
Supplements: Vitamin C	1.2	1.4	2.7	0.4	1.6
Illnesses of father: None of the above (group 1)	1.2	1.4	2.3	-1.5	0.8
Pack years of smoking	1.2	1.8	3.7	0.1	-1.9
Reaction Time	1.1	2.1	4.0	2.0	0.3
Systolic blood pressure, automated reading	1.1	3.2	3.6	-1.9	-1.7
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	2.1	1.5	-0.6
Trunk fat percentage	1.1	4.5	9.0	0.2	-3.0
Medication: Atenolol	1.1	1.4	2.7	-0.3	-1.7
Time employed in main current job	1.1	1.2	2.5	0.1	-1.6
Father’s age at death	1.1	1.5	2.2	0.8	1.5
Impedance of arm (left)	1.1	5.1	10.1	3.2	0.4
Blood clot in the leg (DVT)	1.1	1.5	2.0	1.4	1.0
Medication: Omeprazole	1.1	1.3	2.2	-0.7	1.5
Leg pain on walking	1.1	1.4	2.8	-0.3	-1.7
Knee pain experienced in last month	1.1	1.8	2.5	-1.0	-1.6
Friendships satisfaction	1.1	1.4	2.2	0.8	1.5
Alcohol drinker status: Never	1.1	1.3	1.5	1.2	-1.0
Ulcerative Colitis	1.0	1.5	3.0	-0.0	1.7
Ever used hormone-replacement therapy (HRT)	1.0	1.3	2.1	0.7	-1.4
Medication: Levothyroxine sodium	1.0	1.7	3.4	-0.1	-1.9
Trunk fat-free mass	1.0	5.5	8.0	-1.8	-2.8
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	2.0	1.0	1.4
Headache pain in last month	1.0	1.7	2.0	1.4	1.2
Arm predicted mass (right)	1.0	5.0	5.5	-2.1	-2.4
Age at last live birth	1.0	1.5	1.9	1.4	-1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	2.0	-1.4	0.5
Handedness (chirality/laterality): Left-handed	1.0	1.2	1.4	1.0	-1.2
Osteoarthritis (self-reported)	1.0	1.3	2.4	-1.6	-0.3
Medication: Aspirin	1.0	1.3	2.0	-1.4	0.8
Medication: Paracetamol	1.0	1.5	2.5	1.6	-0.7
Ever depressed for a whole week	1.0	1.3	1.3	1.1	1.1
Myopia	1.0	1.5	3.0	-0.2	1.7
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	1.4	1.2	1.1
Leg fat mass (left)	1.0	4.0	6.2	-1.4	-2.5
Mean Putamen Volume	0.9	1.1	1.6	-0.8	1.3
Tinnitus: Yes, but not now, but have in the past	0.9	0.9	1.3	-0.8	1.1
Trunk predicted mass	0.9	5.2	7.5	-1.7	-2.7
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.1	1.8	1.4	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.0	2.0	0.2	1.4
Leg fat mass (right)	0.9	3.6	5.5	-1.3	-2.4
Alcohol intake frequency.	0.9	2.1	3.7	1.9	-0.7
Commuting to job workplace: Cycle	0.9	1.1	2.1	0.1	1.5
Heart disease (siblings)	0.9	1.1	2.1	-0.1	-1.4
Blood Eosinophil Count	0.8	6.2	12.1	0.5	3.5
Cardiovascular Disease	0.8	2.7	3.1	-1.5	1.8
Type 2 Diabetes (T2D) (2018)	0.8	1.4	2.2	-0.8	1.5
Townsend deprivation index at recruitment	0.8	1.1	2.2	-0.3	1.5
Serious illness, injury or assault to yourself	0.8	0.9	1.3	1.1	0.8
Hair/balding pattern: Pattern 2	0.8	1.1	2.1	0.1	1.4
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	1.5	1.2	-0.7
Body fat percentage	0.8	3.3	6.6	-0.2	-2.6
Arm fat-free mass (right)	0.8	4.0	4.4	-2.1	-1.9
Migraine (self-reported)	0.8	0.9	1.4	1.2	0.7
High cholesterol (Self-reported)	0.8	1.5	3.0	-0.0	1.7
Arm fat-free mass (left)	0.8	4.1	6.1	-1.4	-2.5
Arm predicted mass (left)	0.8	3.9	5.6	-1.5	-2.4
Rheumatoid Arthritis	0.7	1.0	1.6	-1.2	0.6
Hypothyroidism (self reported)	0.7	1.7	2.2	-1.1	-1.5
Chronotype (morning person)	0.7	1.5	3.0	-0.3	1.7
Relative age voice broke	0.7	1.0	1.0	1.0	1.0
Chronic bronchitis/emphysema (father)	0.7	0.8	0.9	0.8	-0.9
Waist circumference	0.7	2.5	2.6	-1.5	-1.6
Financial difficulties in last 2 years	0.7	1.0	1.5	-1.2	0.7
Medication: Simvastatin	0.7	1.0	1.7	-0.5	-1.3
Prospective memory result	0.7	0.9	1.3	0.7	-1.1
Qualifications: O levels/GCSEs or equivalent	0.7	1.2	1.7	0.8	1.3
Exposure to tobacco smoke outside home	0.7	0.9	1.7	0.4	1.3
Number of full brothers	0.7	0.9	1.6	-0.4	1.2
Mean time to correctly identify matches	0.7	1.3	2.4	1.6	0.4
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	1.6	-1.3	-0.3
Long-standing illness, disability or infirmity	0.7	1.1	1.7	-0.7	1.3
Commuting to job workplace: Walk	0.7	0.7	1.3	0.4	-1.1
Eye problems/disorders: Cataract	0.7	0.8	1.5	0.3	-1.2
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	0.9	-1.0	-0.6
Qualifications: CSEs or equivalent	0.6	0.7	1.5	1.2	-0.0
Supplements: Glucosamine	0.6	0.8	1.6	-1.3	0.1
Nervous feelings	0.6	1.1	1.9	1.4	-0.6
Hair/balding pattern: Pattern 3	0.6	0.8	1.1	1.1	0.7
Depression (self-reported)	0.6	0.7	1.0	0.6	1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	2.0	3.5	0.7	-1.9
Age at first live birth	0.6	1.0	1.2	1.1	-0.9
Wears glasses or contact lenses	0.6	0.7	1.4	-1.2	-0.2
Fractured/broken bones in last 5 years	0.6	0.8	1.3	1.1	0.6
Cholesterol lowering medication	0.6	0.9	1.1	-0.9	1.1
Basal cell carcinoma (self-reported)	0.6	0.7	1.1	-1.1	-0.6
Heart attack/myocardial infarction (self-reported)	0.6	0.8	1.4	-0.3	-1.2
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.3	1.1	-0.2
Medication: Co-codamol	0.5	0.6	0.7	0.8	-0.6
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.2	1.1	0.1
Heart attack	0.5	0.7	1.3	-0.0	-1.2
Pulse rate	0.5	0.8	1.5	1.2	0.2
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	1.5	0.2	-1.2
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.0	1.0	0.5
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.1	0.3	1.0
Overall health rating	0.5	1.2	2.4	1.5	0.1
Illnesses of siblings: Diabetes	0.5	0.6	1.0	0.5	-1.0
Breast cancer (self-reported)	0.5	0.6	1.1	-0.4	1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	2.0	-0.3	-1.4
Medication: Lisinopril	0.5	0.6	1.0	1.0	0.4
Average weekly beer plus cider intake	0.5	0.8	1.5	-0.2	1.2
Major Depression (MDD)	0.4	0.5	0.6	0.8	-0.6
Ovarian Cancer	0.4	0.5	0.6	-0.8	0.7
HDL Cholesterol	0.4	0.7	1.4	-0.2	-1.2
Systolic Blood Pressure	0.4	2.2	3.2	-1.8	1.1
Number of treatments/medications taken	0.4	0.7	1.3	-1.1	0.3
Ever had hysterectomy (womb removed)	0.4	0.5	0.9	-0.4	-0.9
Angina	0.4	0.5	0.6	-0.7	-0.8
Taking other prescription medications	0.4	0.6	1.0	-1.0	-0.5
Had other major operations	0.4	0.5	0.6	-0.7	-0.6
Falls in the last year	0.4	0.5	0.6	0.6	0.8
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	0.7	0.8	0.4
Medication: Lansoprazole	0.4	0.5	0.9	0.1	-1.0
Medication: Paracetamol	0.4	0.6	1.2	1.1	-0.2
Leg fat percentage (right)	0.4	1.3	2.1	-1.4	-0.7
Comparative body size at age 10	0.4	1.2	2.3	0.4	-1.5
Qualifications: College or University degree	0.4	1.2	1.5	0.9	1.2
Angina (self-reported)	0.4	0.5	0.6	-0.8	-0.6
Comparative height size at age 10	0.4	2.2	3.5	-1.9	-0.9
Medication: Aspirin	0.4	0.5	1.0	-1.0	0.3
Mother’s age at death	0.4	0.5	0.9	-0.2	1.0
Financial situation satisfaction	0.4	0.5	0.6	-0.8	0.6
Medication: Blood pressure	0.4	0.8	1.6	-0.2	-1.3
Medication: Bendroflumethiazide	0.4	0.6	1.1	-0.5	1.0
Leg fat percentage (left)	0.4	1.5	2.5	-1.6	-0.7
Hair Pigment	0.3	7.7	14.9	-0.6	3.9
Medication for hormone replacement therapy	0.3	0.3	0.5	-0.4	-0.7
Diabetes (mother)	0.3	0.3	0.5	0.4	-0.7
Maternal smoking around birth	0.3	0.4	0.5	-0.7	-0.5
Forced vital capacity (FVC)	0.3	1.3	2.6	0.3	-1.6
Qualifications: None of the above	0.3	0.6	1.1	-0.2	-1.0
Diabetes (self-reported)	0.3	0.5	1.0	-0.2	1.0
Fluid intelligence score	0.3	0.6	0.9	0.5	0.9
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	1.8	0.6	-1.4
Mouth/teeth dental problems: Bleeding gums	0.3	0.3	0.4	0.5	0.6
Forced vital capacity (FVC), Best measure	0.3	1.1	2.2	0.2	-1.5
Neck or shoulder pain in last month	0.3	0.5	0.8	0.9	0.5
Hypertension (Self-reported)	0.3	0.8	1.4	-0.5	1.2
Ever had bowel cancer screening	0.3	0.3	0.5	-0.7	0.4
Qualifications: nursing, teaching	0.3	0.4	0.6	0.7	0.5
Medication for cholesterol	0.3	0.5	0.6	0.6	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.5	-0.7	0.4
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.7	-0.2	-0.9
Diastolic blood pressure, automated reading	0.3	1.1	1.1	1.0	-1.0
Pain experienced in last month	0.3	0.5	0.6	0.8	0.7
Relative age of first facial hair	0.2	0.4	0.8	-0.9	0.1
Supplements: Zinc	0.2	0.2	0.2	0.4	0.4
Medication: Metformin	0.2	0.3	0.5	-0.4	0.7
Sitting height	0.2	1.7	2.0	1.4	-1.2
Number of incorrect matches in round	0.2	0.3	0.4	0.5	-0.6
Pain all over the body in last month	0.2	0.3	0.4	0.4	-0.6
Alcohol intake versus 10 years previously	0.2	0.2	0.4	0.6	-0.2
Noisy workplace	0.2	0.3	0.6	0.1	-0.8
Length of working week for main job	0.2	0.3	0.3	0.4	-0.6
Peak expiratory flow (PEF)	0.2	0.4	0.5	-0.5	0.7
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.4	0.1	0.6
Shortness of breath walking on level ground	0.2	0.2	0.4	-0.6	-0.0
Medication: Seretide 50 evohaler	0.2	0.2	0.5	-0.7	-0.1
Diabetes diagnosed by doctor	0.2	0.3	0.6	0.3	0.8
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	0.5	0.5	-0.7
Average weekly champagne plus white wine intake	0.2	0.3	0.6	0.8	-0.1
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.4	-0.6	0.1
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.2	-0.4	0.5
Alzheimer’s Disease (in father)	0.1	0.2	0.2	0.5	0.3
Verbal and Numeric Reasoning (VNR)	0.1	0.4	0.7	0.2	0.8
Height	0.1	2.4	4.6	0.4	-2.1
Lung FEV1/FVC ratio	0.1	0.5	0.5	0.7	0.7
Vitamin and mineral supplements	0.1	0.1	0.2	0.4	0.3
High blood pressure	0.1	0.2	0.4	-0.2	0.6
Medication: Cholesterol lowering	0.1	0.2	0.4	-0.6	-0.0
Eye problems/disorders: None of the above	0.1	0.2	0.2	0.3	0.5
Medication for pain relief, constipation, heartburn	0.1	0.2	0.3	-0.2	-0.6
Medication: Ibuprofen	0.1	0.1	0.1	0.4	0.3
Number of full sisters	0.1	0.1	0.1	-0.3	-0.2
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.2	-0.4	0.1
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.2	-0.5	0.1
Back pain experienced in last month	0.1	0.2	0.3	-0.1	-0.6
Mineral and other dietary supplements	0.1	0.1	0.2	-0.1	0.4
Supplements: Calcium	0.1	0.1	0.1	0.2	-0.3
Intelligence (Savage-Jansen 2018)	0.0	0.0	0.1	0.1	0.3
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Blood White Count	0.0	0.2	0.2	-0.4	0.5
Diabetes (father)	0.0	0.0	0.1	-0.1	-0.2
Current tobacco smoking	0.0	0.0	0.0	0.1	-0.0
Age when periods started (menarche)	0.0	0.1	0.2	0.2	-0.4
Standing height	0.0	0.4	0.7	-0.2	-0.8
Exposure to tobacco smoke at home	0.0	0.0	0.0	0.2	0.0
Medication: Amlodipine	0.0	0.0	0.0	-0.2	0.1
Health satisfaction	0.0	0.0	0.1	-0.3	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.0	0.0	0.0	-0.1	0.1
Average weekly red wine intake	0.0	0.0	0.1	-0.3	0.1
Smoking status: Current	0.0	0.0	0.1	0.3	0.0
Number of operations (self-reported)	0.0	0.1	0.1	-0.3	-0.2
Vascular/heart problems diagnosed by doctor	0.0	0.1	0.2	0.4	-0.2

Hub : Genes

MTX1

Models

Trait associations