TWAS hub - DNAJC16

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Visceral Omentum	0.1900	0.0630	1.2e-03	0.028	NA	0.062	NA	0.028	1.3e-02	NA	3.9e-04	NA	1.3e-02
2	GTEx	Brain Hypothalamus	0.4180	0.1270	2.2e-03	0.006	NA	0.076	NA	0.113	2.3e-01	NA	7.5e-03	NA	1.3e-03
3	GTEx	Heart Atrial Appendage	0.1540	0.0590	6.5e-03	0.019	NA	0.050	NA	0.061	4.6e-02	NA	2.6e-03	NA	1.1e-03
4	GTEx	Testis	0.1960	0.0700	3.0e-03	0.034	NA	0.042	NA	0.039	1.2e-02	NA	6.0e-03	NA	7.8e-03
5	ROSMAP	Brain Pre-frontal Cortex	0.0669	0.0249	1.6e-03	0.025	0.032	0.024	0.034	0.026	3.1e-04	4.7e-05	3.5e-04	3e-05	2.4e-04
6	TCGA	Thyroid Carcinoma	0.0930	0.0520	1.7e-06	0.069	0.058	0.044	NA	0.061	2.9e-07	2.5e-06	3.6e-05	NA	1.4e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Comparative body size at age 10	5.6	15.4	31.7	-3.0	0.3	-5.6	-2.7	-4.7	-4.7
Gout (self-reported)	3.8	5.3	7.3	-2.5	0.1	-2.1	-2.7	-2.7	-2.5
High cholesterol (Self-reported)	3.6	6.3	10.3	1.6	2.5	1.4	2.7	3.2	3.1
Noisy workplace	3.4	4.2	7.6	-1.1	-1.5	-2.5	-1.5	-2.8	-2.4
Chronotype (morning person)	3.1	7.2	15.6	-2.5	-0.6	-3.3	-2.4	-2.1	-3.9
Eye problems/disorders: Diabetes related eye disease	3.1	3.4	6.0	-0.9	-0.9	-2.2	-2.5	-1.7	-2.2
Impedance of leg (left)	3.1	14.9	19.5	3.6	3.1	4.3	3.4	4.1	4.4
Lupus	3.0	4.5	8.9	-1.2	-0.0	-2.8	-1.8	-2.5	-3.0
Medication: Atenolol	3.0	3.7	7.5	-2.1	-1.3	-1.7	-1.3	-2.7	-2.0
Crohns Disease (2012)	2.8	4.5	10.7	0.7	-0.9	-2.4	-3.3	-1.6	-2.6
Blood Red Count	2.8	27.4	45.3	2.5	5.1	4.2	6.7	6.1	5.7
Supplements: Calcium	2.8	3.1	7.2	-1.0	1.1	-0.9	-2.7	-2.3	-1.7
Impedance of whole body	2.8	14.5	19.0	3.8	3.0	4.4	3.2	3.9	4.3
Hearing aid user	2.7	3.0	6.8	1.2	1.5	2.6	0.9	1.9	1.8
Impedance of leg (right)	2.6	12.8	15.4	3.6	3.2	3.6	3.3	3.9	3.8
Qualifications: CSEs or equivalent	2.5	3.3	6.3	-1.2	-2.5	-2.0	-0.7	-2.1	-1.8
Chronic bronchitis/emphysema (father)	2.5	2.9	7.0	2.6	-0.1	0.0	2.6	1.6	0.9
Heel bone mineral density (BMD) T-score, automated (right)	2.4	5.5	14.7	3.8	-0.5	0.7	3.6	1.1	1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.4	2.9	4.1	-0.9	-1.8	-2.0	-2.0	-1.3	-1.9
Handedness (chirality/laterality): Left-handed	2.4	2.8	5.2	-2.3	0.7	-2.2	-1.3	-0.8	-2.0
BMI	2.3	13.3	24.3	-1.2	-2.9	-4.9	-3.4	-3.4	-4.7
Heel T-Score	2.2	17.6	74.8	8.7	1.4	1.2	4.5	1.7	2.1
Alcohol usually taken with meals	2.2	3.6	5.1	2.3	1.0	1.6	2.1	2.2	1.8
Medication: Allopurinol	2.2	2.9	5.3	-1.8	-0.3	-1.1	-2.3	-2.2	-1.6
Lung FEV1/FVC ratio	2.1	10.5	25.5	-1.2	-5.0	-2.0	-4.0	-2.9	-2.7
Medication: Atorvastatin	2.1	2.6	4.1	1.4	1.2	1.6	1.7	2.0	1.6
Average weekly beer plus cider intake	2.1	3.1	5.9	-1.2	-1.7	-1.9	-2.4	-1.7	-1.3
Crohns Disease (2017)	2.0	4.4	6.9	1.1	-1.8	-2.0	-2.6	-2.4	-2.3
Impedance of arm (left)	2.0	9.3	13.4	3.3	2.1	3.7	2.5	3.1	3.3
Illness, injury, bereavement, stress in last 2 years	2.0	2.5	5.2	0.2	0.1	1.7	2.0	1.6	2.3
Medication: Co-codamol	1.9	2.2	3.7	-1.0	0.3	-1.9	-1.9	-1.4	-1.6
Diabetes (father)	1.9	2.3	4.9	-1.1	-0.3	-2.1	-2.2	-0.6	-1.7
Body mass index (BMI)	1.9	8.0	13.1	-2.0	-2.7	-3.6	-2.1	-2.5	-3.5
Glaucoma (self-reported)	1.9	2.3	3.7	-0.2	-0.7	-1.9	-1.6	-1.9	-1.8
Average weekly spirits intake	1.8	2.3	4.7	-2.2	-1.5	-1.1	-1.3	-1.4	-1.2
Heel bone mineral density (BMD) T-score, automated (left)	1.8	4.0	13.8	3.7	0.2	0.5	2.9	0.9	1.0
Loneliness, isolation	1.8	2.5	4.3	-0.2	-1.0	-2.1	-1.6	-1.9	-1.8
Father’s age at death	1.7	2.3	9.4	-1.2	-3.1	-0.2	0.8	-1.2	-0.8
Ever highly irritable/argumentative for 2 days	1.7	2.1	7.0	1.3	0.7	2.6	1.4	0.3	1.2
Alcohol intake frequency.	1.7	3.9	14.8	3.9	0.6	0.1	2.5	1.1	0.8
Ulcerative Colitis (UC)	1.6	2.9	11.0	3.3	-0.3	1.2	1.8	0.6	1.2
Hearing difficulty/problems: Yes	1.6	2.5	6.4	0.8	0.1	0.9	1.4	2.5	2.2
Pulse wave peak to peak time	1.6	1.9	3.7	1.2	-0.5	1.9	1.6	0.8	1.6
Sitting height	1.5	10.9	19.6	2.8	1.3	3.6	2.8	4.4	3.9
Impedance of arm (right)	1.5	7.2	9.9	2.5	2.5	3.1	2.0	2.8	3.0
Chronic bronchitis/emphysema (mother)	1.5	1.8	4.9	-0.1	0.3	-2.2	-0.9	-1.3	-1.7
High blood pressure (siblings)	1.5	2.2	3.9	-2.0	1.1	-1.8	-0.7	-1.5	-1.6
Medication: Ibuprofen	1.5	1.8	5.8	-1.3	0.5	-0.5	-2.4	-0.6	-1.5
Cholesterol lowering medication	1.5	2.2	3.5	-0.4	1.3	1.7	1.2	1.9	1.9
Intelligence (Savage-Jansen 2018)	1.4	4.4	7.7	0.5	2.0	2.8	1.7	2.3	2.5
LDL Cholesterol	1.4	2.2	6.1	0.6	-0.0	2.5	1.1	1.5	1.9
Allergy or Eczema	1.4	3.6	6.7	-1.6	1.8	2.6	-2.2	1.5	1.4
Illnesses of siblings	1.4	2.0	3.7	1.3	-1.2	1.3	1.2	1.3	1.9
Qualifications: NVQ or HND or HNC or equivalent	1.4	1.7	5.2	0.9	0.2	-2.3	-0.6	-1.7	-0.9
Illnesses of father: Heart disease	1.4	2.0	4.1	-1.4	-0.3	2.0	-0.6	1.7	1.6
Ever had bowel cancer screening	1.4	1.6	5.8	1.0	0.3	2.4	0.6	0.9	1.2
Ever had stillbirth, spontaneous miscarriage or termination	1.4	1.5	2.5	-0.8	-0.5	-1.6	-1.4	-1.0	-1.6
Eye problems/disorders: Glaucoma	1.4	1.7	2.8	0.6	0.7	-1.2	-1.5	-1.6	-1.7
Pain all over the body in last month	1.3	1.4	4.0	0.5	1.4	-2.0	-0.6	-0.7	-1.1
Medication: Cholesterol lowering	1.3	2.0	4.6	1.3	0.4	0.7	1.2	1.8	2.1
Illnesses of mother	1.3	1.6	4.1	2.0	0.7	1.5	1.3	0.4	1.0
Birth weight	1.3	2.7	4.9	1.1	0.4	2.2	1.9	1.7	1.8
Emphysema/chronic bronchitis	1.3	1.5	3.5	1.3	1.1	0.4	1.9	0.9	1.3
Osteoporosis (self-reported)	1.3	1.6	5.8	-2.4	1.2	-0.5	-1.1	-1.0	-0.4
Medication: Gliclazide	1.3	1.5	4.8	1.4	-2.2	1.1	0.4	0.6	0.7
Tinnitus: Yes, now most or all of the time	1.3	1.5	2.4	-1.0	-0.2	-1.6	-1.5	-1.0	-1.5
Worry (Nagel 2018)	1.2	2.5	4.8	0.8	1.1	2.2	1.5	1.7	1.8
HbA1C	1.2	1.3	2.5	-0.3	-0.9	-1.6	-1.3	-1.2	-1.1
Number of treatments/medications taken	1.2	2.2	5.4	-0.6	0.6	-1.3	-2.3	-1.4	-1.8
Leg predicted mass (left)	1.2	6.1	7.7	-2.1	-2.8	-2.7	-2.5	-2.0	-2.6
Waist circumference	1.2	4.5	8.6	-1.5	-1.2	-2.7	-1.7	-2.1	-2.9
Hair/balding pattern: Pattern 3	1.2	1.8	4.5	-0.2	-0.3	-2.1	-1.6	-1.1	-1.6
Medication: Seretide 50 evohaler	1.2	1.4	4.6	-0.3	2.2	0.1	1.8	0.7	0.2
Smoking status: Current	1.2	1.9	3.6	-1.0	-1.1	-1.6	-1.9	-1.6	-0.6
Medication: Omeprazole (e.g. Zanprol)	1.2	1.5	2.1	-1.4	-1.4	-1.0	-1.1	-1.0	-1.3
Arm predicted mass (left)	1.2	6.1	8.6	-2.5	-2.4	-2.9	-2.5	-1.9	-2.6
Age at First Birth	1.1	1.5	2.7	0.9	-0.9	1.0	1.2	1.6	1.6
Bipolar Disorder (2011)	1.1	1.1	1.8	-0.2	1.1	1.0	1.3	1.3	0.7
Leg fat-free mass (left)	1.1	5.9	7.7	-2.1	-2.8	-2.7	-2.5	-1.9	-2.5
Age when periods started (menarche)	1.1	2.7	7.6	-1.7	-1.0	-0.5	-2.8	-1.5	-1.5
Prospective memory result	1.1	1.4	2.9	0.7	-0.3	-1.3	0.0	-1.7	-1.7
Pulse wave Arterial Stiffness index	1.1	1.3	2.5	-1.0	0.4	-1.6	-1.4	-0.5	-1.4
Medication: Amlodipine	1.1	1.5	4.1	0.2	2.0	-1.0	-1.4	-0.4	-1.4
Forced vital capacity (FVC), Best measure	1.1	4.1	5.9	-0.2	2.4	2.2	2.0	2.2	2.2
Pulse rate, automated reading	1.1	3.5	6.5	0.7	-0.4	1.7	2.5	2.2	2.5
Whole body fat-free mass	1.1	6.1	7.8	-2.3	-2.5	-2.8	-2.7	-1.9	-2.6
Leg fat-free mass (right)	1.1	5.7	8.1	-2.2	-2.8	-2.4	-2.5	-2.0	-2.3
Qualifications: nursing, teaching	1.1	1.7	3.4	-0.7	1.8	1.4	0.7	1.5	1.2
Alzheimer’s Disease (in father)	1.0	1.1	1.9	1.4	-0.5	0.9	1.3	0.5	1.3
Prostate Cancer	1.0	1.4	4.1	-2.0	0.8	-0.6	-1.5	-0.0	-1.1
Lung FVC	1.0	5.0	15.2	0.5	3.9	1.3	2.3	2.4	1.5
Bilateral oophorectomy (both ovaries removed)	1.0	1.1	1.8	1.0	-0.1	-1.2	1.1	-1.0	-1.4
Hayfever, allergic rhinitis or eczema	1.0	2.3	5.3	-1.2	1.0	2.3	-1.4	1.3	1.5
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	4.1	1.1	-2.0	1.0	-0.7	0.3	0.5
High blood pressure (mother)	1.0	1.4	6.2	-2.5	-0.3	-0.8	0.7	0.9	0.0
Medication: Simvastatin	1.0	1.5	3.3	-0.0	0.4	1.0	1.0	1.8	1.8
Fluid intelligence score	1.0	2.0	3.6	1.1	1.6	1.9	0.2	1.5	1.5
Weight	1.0	4.7	6.8	-1.5	-2.4	-2.5	-2.1	-1.6	-2.6
Medication: Paracetamol	1.0	1.7	4.0	1.5	0.9	2.0	0.7	1.1	1.2
Mouth/teeth dental problems: Loose teeth	1.0	1.2	4.7	-0.9	-0.5	0.5	2.2	0.9	0.5
Osteoarthritis (self-reported)	1.0	1.3	5.9	1.1	2.4	-0.3	-0.6	-0.3	-0.0
Illnesses of father: None of the above (group 1)	1.0	1.2	3.8	-0.1	2.0	-0.8	0.5	-1.2	-1.1
Whole body water mass	1.0	5.9	7.1	-2.3	-2.5	-2.7	-2.6	-1.9	-2.5
Leg predicted mass (right)	1.0	5.3	8.0	-2.1	-2.8	-2.3	-2.4	-1.9	-2.2
Guilty feelings	1.0	1.6	3.5	-0.8	1.1	-0.5	-1.9	-0.7	-1.8
Financial situation satisfaction	1.0	1.2	3.1	0.0	-0.9	-1.8	-1.2	-0.2	-1.4
Basal metabolic rate	1.0	5.7	7.6	-2.1	-2.6	-2.8	-2.5	-1.8	-2.5
Arm fat-free mass (left)	1.0	5.1	7.4	-2.3	-2.1	-2.7	-2.1	-1.8	-2.4
Breast Cancer	0.9	2.3	4.6	-0.6	0.9	-2.0	0.7	-2.1	-1.8
Smoking Status	0.9	2.0	4.5	-1.3	-1.0	-1.5	-2.1	-1.3	-1.0
Current tobacco smoking	0.9	1.5	3.3	-1.1	-0.9	-1.4	-1.8	-1.3	-0.3
Stomach or abdominal pain in last month	0.9	1.1	4.6	0.7	0.5	2.2	0.4	0.8	0.9
Trunk fat-free mass	0.9	5.1	6.6	-2.1	-2.1	-2.6	-2.5	-1.6	-2.4
Trunk predicted mass	0.9	5.1	6.4	-2.1	-2.2	-2.5	-2.5	-1.7	-2.4
Arm fat-free mass (right)	0.9	4.8	6.6	-2.1	-2.6	-2.3	-2.2	-1.6	-2.3
Had major operations	0.9	1.1	2.6	1.5	1.6	0.9	-0.9	0.3	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	3.2	-0.1	-0.2	1.5	0.9	1.5	1.8
Arm fat mass (left)	0.9	3.6	5.7	-1.2	-2.3	-2.4	-1.3	-1.4	-2.3
Age started oral contraceptive pill	0.9	1.1	2.0	0.8	0.1	1.4	1.1	1.0	1.4
Bipolar Disorder (2018)	0.8	1.2	1.9	0.3	-0.7	1.3	1.4	1.2	1.4
Irritable Bowel Disease (IBD)	0.8	2.0	9.2	3.0	-1.0	-0.5	-0.3	-1.1	-0.7
Mean Putamen Volume	0.8	0.9	4.3	0.4	-2.1	1.1	0.1	0.1	0.3
Fasting Glucose	0.8	1.0	3.4	-0.0	0.5	-0.2	0.6	1.8	1.4
Angina	0.8	1.1	3.5	-1.2	0.2	-1.1	-1.9	-0.5	-0.6
Serious illness, injury or assault to yourself	0.8	0.9	3.6	1.9	1.1	0.2	0.3	0.9	0.3
Nervous feelings	0.8	1.5	3.4	0.9	1.1	1.4	0.8	1.8	1.1
Hair/balding pattern: Pattern 2	0.8	1.0	2.1	0.9	-1.0	0.9	0.5	0.9	1.5
Had other major operations	0.8	0.9	1.5	-1.0	0.1	-1.0	-0.9	-1.2	-1.1
Diabetes (self-reported)	0.8	1.3	2.6	1.3	-0.9	0.9	-0.1	1.6	1.3
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	4.1	-1.0	-0.2	0.4	-2.0	-0.4	-0.6
Hair/balding pattern: Pattern 4	0.8	1.9	4.1	-0.9	-0.6	-1.2	-0.8	-2.0	-2.0
Blood clot in the leg (DVT)	0.8	1.0	3.6	0.2	-0.6	-1.9	-0.7	-0.2	-1.1
Eye problems/disorders: None of the above	0.8	0.9	2.4	0.8	0.3	0.5	1.5	0.7	1.2
Angina (self-reported)	0.8	1.1	3.1	-1.2	0.2	-1.2	-1.8	-0.4	-0.6
Commuting to job workplace: Car/motor vehicle	0.8	1.0	2.1	1.1	-1.4	0.5	-0.4	0.9	1.1
Ever depressed for a whole week	0.8	1.0	2.6	1.1	1.3	0.1	1.6	0.7	0.4
Alcohol drinker status: Previous	0.8	0.9	3.1	1.8	0.2	-0.6	0.9	1.0	0.1
Verbal and Numeric Reasoning (VNR)	0.7	1.7	4.4	0.4	1.5	0.8	0.6	2.1	1.5
Type 2 Diabetes (T2D) (2018)	0.7	1.2	3.0	1.7	-0.3	1.0	0.1	1.7	0.8
Sensitivity / hurt feelings	0.7	1.3	2.9	-1.2	-0.4	-0.1	-1.4	-1.7	-1.1
Ever used hormone-replacement therapy (HRT)	0.7	1.0	2.1	1.5	0.4	1.2	0.2	0.9	1.1
Pack years adult smoking proportion	0.7	1.0	2.6	1.0	-1.6	-0.6	1.1	0.1	1.0
Maternal smoking around birth	0.7	1.0	2.7	1.6	1.6	-0.2	0.3	0.7	0.4
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	1.6	-0.3	0.5	-0.5	-1.2	-1.3	-0.8
Hearing difficulty/problems with background noise	0.7	1.2	2.5	-1.6	0.0	-1.6	-1.3	0.4	-0.3
Arm fat percentage (right)	0.7	2.8	5.5	-0.9	-1.6	-2.4	-1.1	-1.3	-2.2
Number of live births	0.7	1.0	2.0	-0.2	-0.5	-1.4	-1.3	0.3	-1.4
Mouth/teeth dental problems: Dentures	0.7	1.2	1.9	0.4	0.6	-1.2	-1.2	-1.4	-1.4
Arm fat mass (right)	0.7	3.0	4.8	-1.3	-2.2	-2.2	-1.1	-1.3	-2.1
Number of full brothers	0.7	0.9	3.6	-0.9	-1.9	-0.9	-0.1	-0.2	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	3.0	0.1	1.7	-0.5	1.0	-0.9	-0.3
Whole body fat mass	0.7	2.9	4.8	-0.9	-2.1	-2.2	-1.1	-1.4	-2.1
Leg fat mass (right)	0.7	2.5	5.2	-0.6	-1.9	-2.3	-0.9	-1.2	-1.9
Arm predicted mass (right)	0.7	3.8	5.8	-2.0	-2.4	-2.0	-1.8	-1.4	-1.9
Medication: Paracetamol	0.7	1.1	1.9	1.3	0.9	1.4	0.5	1.1	0.9
Pack years of smoking	0.7	1.0	2.0	1.1	-1.4	-0.5	1.2	0.0	1.0
Leg fat mass (left)	0.7	2.9	5.1	-1.0	-2.0	-2.3	-1.1	-1.5	-2.0
Bipolar Disorder or Schizophrenia	0.6	1.4	3.7	0.6	0.0	1.1	1.2	1.9	1.2
Alzheimer’s Disease (in mother)	0.6	0.7	1.4	-1.2	0.6	0.9	1.1	0.3	0.5
Major Depression (MDD)	0.6	0.7	3.1	-0.3	1.8	-0.2	0.1	-0.7	-0.8
Reaction Time	0.6	1.2	2.7	1.6	0.3	0.1	1.5	0.1	1.4
Body Mass Index (BMI) (2010)	0.6	0.8	1.6	-0.7	-0.0	-0.7	-1.0	-1.1	-1.2
Coronary Artery Disease (CAD)	0.6	0.7	1.3	-0.1	1.0	0.6	-1.0	1.1	0.7
Neuroticism (2016)	0.6	0.9	2.1	1.5	0.9	0.3	-0.3	1.0	1.0
Systolic Blood Pressure	0.6	3.1	7.1	-2.7	0.6	1.4	-1.6	1.4	2.1
Respiratory disease	0.6	1.2	1.8	1.3	1.0	1.3	0.6	1.1	1.2
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	1.4	-0.5	1.0	-1.2	-0.8	-0.8	-1.0
Medication for hormone replacement therapy	0.6	0.7	2.0	1.4	1.0	1.0	-0.0	0.4	0.2
Townsend deprivation index at recruitment	0.6	0.8	2.3	1.1	-1.5	-0.8	0.0	-0.6	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.7	1.8	0.8	-0.7	0.1	-1.4	1.0	0.6
Forced vital capacity (FVC)	0.6	2.4	4.5	-0.7	2.1	1.5	1.5	1.6	1.6
Allergy	0.6	1.4	2.8	0.3	-1.0	-1.7	0.8	-1.1	-1.5
Hip circumference	0.6	2.6	4.4	-1.4	-1.6	-1.9	-0.8	-1.6	-2.1
Alcohol intake versus 10 years previously	0.6	0.9	1.8	1.1	0.5	-1.2	0.4	-0.7	-1.3
Qualifications: A levels/AS levels or equivalent	0.6	1.3	4.7	-0.8	0.7	2.2	-0.9	1.0	0.7
Headache pain in last month	0.6	1.0	5.2	2.3	0.7	0.6	0.3	0.1	0.2
Exposure to tobacco smoke outside home	0.6	0.8	2.1	0.7	1.0	-1.4	0.1	-1.1	-0.3
Number of children fathered	0.6	0.6	2.0	0.2	-0.4	1.4	0.8	0.1	0.9
Age at first live birth	0.6	1.1	4.9	0.3	-2.2	0.9	0.7	-0.1	0.3
Chest pain or discomfort	0.6	0.8	1.8	1.4	-0.6	0.5	0.3	1.2	0.9
Arm fat percentage (left)	0.6	2.5	4.7	-0.6	-1.8	-2.2	-0.9	-1.2	-2.1
Back pain experienced in last month	0.6	0.8	2.5	-1.4	-0.3	-0.3	-1.6	-0.7	-0.4
Wears glasses or contact lenses	0.6	0.7	2.2	1.5	0.4	0.8	0.2	0.9	0.8
Risk taking	0.6	0.8	1.3	-1.1	-0.7	-1.1	-1.1	-0.7	-0.7
Commuting to job workplace: Cycle	0.6	0.7	1.5	-0.4	0.6	-0.6	-1.1	-0.7	-1.2
Myopia	0.6	0.8	2.6	-1.2	0.5	-0.5	-0.1	-0.6	-1.6
Rheumatoid Arthritis	0.5	0.6	2.4	-1.5	-0.4	-0.4	-0.9	0.2	-0.6
Height	0.5	9.0	17.6	0.1	0.6	3.9	2.2	4.2	4.0
Cardiovascular Disease	0.5	1.5	4.2	-0.5	0.3	0.8	0.2	2.1	1.9
Ever had hysterectomy (womb removed)	0.5	0.6	1.5	0.7	1.2	-0.5	1.0	-0.5	-0.6
Systolic blood pressure, automated reading	0.5	1.5	4.9	-2.2	0.4	0.7	-1.7	0.5	0.8
Relative age voice broke	0.5	0.7	1.4	0.4	1.2	-0.8	-1.2	-0.4	-0.7
Medication: Levothyroxine sodium	0.5	0.8	2.5	-0.9	-1.6	-0.8	-0.4	-0.5	-0.6
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.7	1.3	0.3	0.5	0.8	1.1	0.1
Time employed in main current job	0.5	0.6	1.0	1.0	-0.7	0.7	0.7	-0.9	0.5
Worrier / anxious feelings	0.5	0.9	1.7	0.1	0.9	1.3	0.9	1.1	1.1
Happiness	0.5	0.6	2.2	0.5	0.3	0.0	1.5	0.7	0.6
Medication: Lansoprazole	0.5	0.5	2.0	-0.1	-1.4	-0.3	-0.7	-0.8	0.3
Lung cancer (father)	0.5	0.5	2.2	1.5	-0.1	-0.5	-0.3	-0.2	-0.8
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.5	-0.2	1.2	0.8	0.3	1.0	0.8
Leg fat percentage (right)	0.5	1.9	5.2	-0.0	-1.1	-2.3	-0.4	-1.0	-2.0
Wheeze or whistling in the chest in last year	0.5	0.9	2.6	1.6	0.4	0.9	0.2	0.8	1.0
Migraine (self-reported)	0.5	0.6	1.8	1.4	0.1	0.6	0.6	0.8	0.5
Family relationship satisfaction	0.5	0.6	1.6	-0.3	-0.8	-0.2	1.1	0.5	1.3
Knee pain experienced in last month	0.5	0.7	2.0	-1.4	-1.4	0.2	-0.4	-0.3	-0.2
Illnesses of siblings: Diabetes	0.5	0.6	1.3	-0.8	-0.9	-0.9	-0.1	-0.3	-1.2
Average weekly red wine intake	0.5	0.7	2.7	1.6	0.5	0.6	0.9	0.6	0.3
Diabetes diagnosed by doctor	0.5	0.9	1.9	1.4	-0.9	0.7	-0.4	1.1	0.8
Eye problems/disorders: Cataract	0.5	0.6	2.4	0.3	-1.5	1.0	0.1	-0.1	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	3.5	0.7	1.9	1.1	0.8	0.5	0.3
Pain type(s) experienced in last month: Hip pain	0.5	0.6	2.2	0.3	-1.5	0.9	0.5	-0.3	0.3
Leg fat percentage (left)	0.5	1.9	4.3	-0.3	-1.3	-2.1	-0.6	-1.2	-1.8
Fractured/broken bones in last 5 years	0.5	0.6	1.5	-1.2	-1.0	-0.5	-0.3	-0.9	-0.3
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	2.4	0.7	-0.5	-1.5	-0.2	0.1	-0.8
Ulcerative Colitis	0.4	0.5	1.8	1.4	1.1	-0.1	0.5	-0.0	-0.1
Blood Eosinophil Count	0.4	3.0	7.0	-0.2	-0.0	-0.7	-2.0	-2.5	-2.6
Hypothyroidism (self reported)	0.4	1.0	2.6	-0.2	-1.6	-0.3	-1.4	-0.9	-0.7
Medication: Metformin	0.4	0.6	1.2	0.4	-1.1	0.7	-0.6	0.8	0.8
Hand grip strength (right)	0.4	1.1	1.8	0.4	-1.3	1.4	0.0	1.3	1.1
Fed-up feelings	0.4	0.7	2.6	0.5	-1.6	0.3	-1.0	-0.5	0.2
High blood pressure	0.4	1.1	4.6	-2.1	0.1	-0.7	-1.2	-0.0	-0.1
Supplements: Glucosamine	0.4	0.5	1.9	-0.6	0.0	0.1	-0.3	-1.4	-0.8
Trunk fat mass	0.4	1.8	3.5	-0.4	-1.9	-1.5	-0.9	-0.9	-1.7
Number of incorrect matches in round	0.4	0.6	2.0	-1.4	-0.5	-0.2	-0.5	1.1	0.4
Had menopause	0.4	0.5	1.2	0.5	0.4	0.6	0.8	1.1	0.7
Financial difficulties in last 2 years	0.4	0.5	2.4	0.4	-1.6	-0.1	0.1	0.7	0.4
Medication: Ramipril	0.4	0.5	1.3	1.0	-0.3	0.5	0.5	0.5	1.1
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	3.0	0.3	-0.4	-0.0	0.1	1.7	0.4
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	1.3	0.8	0.6	-1.1	-0.3	-0.7	-0.3
Breastfed as a baby	0.4	0.5	1.2	-1.1	-0.6	1.1	0.0	0.0	0.3
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	1.6	-0.9	0.2	-0.2	-0.4	-1.3	-1.0
Body fat percentage	0.4	1.5	3.1	-0.0	-1.3	-1.8	-0.6	-1.0	-1.7
Worry too long after embarrassment	0.4	0.7	1.3	-0.4	0.9	1.1	-1.0	-0.7	-0.6
Qualifications: College or University degree	0.4	1.4	6.0	-0.6	0.7	2.5	0.1	0.6	1.0
Medication for pain relief, constipation, heartburn	0.4	0.6	1.7	0.2	0.8	-0.2	1.3	0.8	0.8
Neck or shoulder pain in last month	0.4	0.5	1.5	-0.6	0.5	0.8	-1.2	0.7	0.4
Medication: Blood pressure	0.4	0.7	1.8	0.4	0.2	-1.3	-1.1	0.3	-0.9
Medication: Omeprazole	0.4	0.5	1.4	-1.2	-0.8	-0.5	-0.3	-0.5	-0.7
Heart disease (mother)	0.4	0.5	1.4	-0.9	-0.2	-0.9	-1.2	0.4	-0.4
Age at last live birth	0.4	0.6	2.5	0.7	-1.6	0.7	0.5	-0.2	0.0
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	1.7	0.9	0.6	0.9	0.4	1.0	1.3
Commuting to job workplace: Walk	0.4	0.4	1.6	-0.7	1.3	-0.4	-0.1	-0.2	-0.2
Mineral and other dietary supplements	0.4	0.5	1.4	-0.4	-1.0	-0.1	0.2	1.2	0.8
Ever taken oral contraceptive pill	0.4	0.5	1.4	0.9	-0.2	-1.2	-0.4	0.3	-0.5
Diastolic blood pressure, automated reading	0.4	1.1	2.1	-1.5	-1.0	0.6	-0.0	1.3	1.2
Heart disease (siblings)	0.4	0.5	1.0	-0.1	0.1	0.3	-1.0	-0.9	-0.9
Schizophrenia (2018)	0.3	0.5	2.2	0.4	0.5	0.4	0.4	1.5	0.5
Schizophrenia vs Biploar Disorder	0.3	0.4	2.1	-0.0	-1.5	0.3	0.2	0.1	0.2
Alzheimer’s Disease (including proxy)	0.3	0.5	1.2	-0.4	0.2	1.1	1.1	0.3	0.5
HDL Cholesterol	0.3	0.5	0.9	0.2	0.9	0.0	-0.9	-1.0	-0.7
Triglycerides	0.3	0.5	1.7	0.1	1.3	0.8	0.7	0.3	0.5
Type 2 Diabetes (T2D) (2012)	0.3	0.4	1.5	0.1	0.6	-1.2	-0.0	0.3	-0.4
Hand grip strength (left)	0.3	0.8	1.8	0.6	-1.4	0.2	0.7	1.2	0.6
Relative age of first facial hair	0.3	0.7	1.4	0.8	1.2	0.6	0.0	1.0	0.8
Severe depression (siblings)	0.3	0.3	0.8	-0.8	0.1	-0.2	0.4	0.9	0.4
Taking other prescription medications	0.3	0.5	1.4	0.1	1.0	0.5	-1.2	-0.4	-0.4
Mouth/teeth dental problems	0.3	0.4	1.2	-0.0	-1.1	-0.0	1.0	0.1	0.5
Falls in the last year	0.3	0.4	1.5	0.5	0.6	-0.2	-0.3	-1.2	0.0
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	1.5	-1.0	0.7	1.2	0.5	1.0	1.0
Pulse rate	0.3	0.4	1.4	-0.6	-0.3	-0.3	0.6	-1.2	-0.5
Asthma	0.3	0.6	1.0	0.9	1.0	1.0	-0.0	0.7	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	1.8	-0.6	1.0	1.3	0.6	1.1	1.0
Exposure to tobacco smoke at home	0.3	0.3	1.1	0.8	0.1	-1.1	0.1	0.2	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	1.0	-0.8	-0.1	0.1	-0.7	1.0	-0.6
Birth weight of first child	0.3	0.6	1.5	1.1	-0.2	1.2	0.1	0.5	0.5
Pulse wave reflection index	0.3	0.4	1.1	0.4	1.1	-0.8	-0.2	0.7	-0.2
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.6	-0.6	0.9	1.3	-0.3	0.2	0.5
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	2.2	-0.3	-1.5	-0.2	-0.3	-0.6	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.7	0.4	1.3	0.2	-0.3	0.6	-0.5
Number of full sisters	0.3	0.4	1.3	0.6	-1.1	-0.6	0.4	0.3	-0.4
Hypertension (Self-reported)	0.3	0.7	3.1	-1.8	-0.2	-0.4	-1.0	0.1	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	1.2	-0.1	-1.1	-0.4	-0.2	-0.8	-0.5
Smoking status: Previous	0.3	0.5	2.0	-0.3	-0.2	0.8	-0.0	1.4	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.5	0.5	0.7	0.5	0.6	0.5	0.6
Asthma (self-reported)	0.3	0.6	0.9	0.9	0.9	0.9	0.0	0.6	0.6
Miserableness	0.3	0.5	0.9	0.5	0.1	1.0	-1.0	0.6	0.6
Medication: Blood pressure	0.3	0.5	2.3	-1.5	0.4	-0.5	0.2	-0.5	-0.2
Illnesses of father: High blood pressure	0.3	0.4	1.1	0.1	-1.0	-0.7	-0.6	-0.4	-0.0
Number of operations (self-reported)	0.3	0.5	1.2	1.0	0.7	0.0	-0.4	-0.2	-1.1
Vascular/heart problems diagnosed by doctor	0.3	0.9	3.0	1.7	-0.1	0.9	1.2	0.0	0.1
Basal cell carcinoma (self-reported)	0.3	0.4	1.0	-0.4	-0.9	0.6	-1.0	-0.1	-0.4
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.0	0.3	0.4	-1.0	-0.3	-0.8	-0.5
Depressed Affect (Nagel 2018)	0.2	0.3	1.1	0.5	-0.3	0.6	-1.1	-0.2	0.3
Depression (Nagel 2018)	0.2	0.3	1.2	0.2	0.0	0.2	-1.1	0.5	0.7
Neuroticism (Nagel 2018)	0.2	0.5	2.2	0.0	0.7	1.5	-0.5	0.1	0.5
Ovarian Cancer	0.2	0.3	0.6	-0.7	-0.8	-0.5	-0.1	-0.4	-0.5
Primary Biliary Cirrhosis	0.2	0.2	0.6	0.5	0.2	-0.8	0.6	0.0	-0.4
Schizophrenia (2014)	0.2	0.5	1.3	0.6	-0.1	0.4	1.0	1.1	0.7
Blood White Count	0.2	1.2	2.5	0.2	1.6	0.7	1.2	0.8	1.5
Waist Hip Ratio (WHR)	0.2	1.1	4.2	-0.1	2.0	-1.0	-0.8	0.2	-1.0
Neuroticism	0.2	0.4	1.6	-0.2	0.4	1.2	-0.7	-0.0	0.6
Frequency of depressed mood in last 2 weeks	0.2	0.3	1.3	0.3	-0.4	0.6	0.4	-0.1	1.1
Vitamin and mineral supplements	0.2	0.3	0.4	-0.5	-0.5	0.5	0.7	-0.1	0.7
Supplements: Zinc	0.2	0.2	0.4	0.6	0.1	0.4	0.5	0.5	0.1
Trunk fat percentage	0.2	0.8	1.7	0.0	-1.3	-1.1	-0.2	-0.5	-1.3
Average weekly fortified wine intake	0.2	0.3	0.7	-0.3	-0.3	0.8	-0.5	0.4	0.6
Multivitamins +/- minerals	0.2	0.3	0.9	1.0	0.2	-0.3	-0.2	-0.4	-0.5
Heart attack	0.2	0.3	0.6	0.4	0.8	-0.8	-0.3	-0.5	-0.2
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.6	-0.7	0.2	0.5	0.8	0.5	0.4
Neuroticism score	0.2	0.4	0.8	0.7	-0.1	0.9	-0.9	0.2	0.4
Depression (self-reported)	0.2	0.3	0.7	-0.2	-0.1	0.6	0.4	0.9	0.5
Standing height	0.2	2.1	5.2	0.9	0.5	2.3	-0.1	2.0	1.7
Peak expiratory flow (PEF)	0.2	0.5	1.3	-0.7	-1.1	0.8	-0.7	-0.5	-0.1
Loud music exposure frequency	0.2	0.2	0.6	-0.4	-0.8	0.3	-0.1	0.5	0.3
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.8	0.9	0.7	0.2	0.7	0.3	0.2
Health satisfaction	0.2	0.3	1.2	0.2	-0.2	-1.1	0.3	-0.4	-0.5
Shortness of breath walking on level ground	0.2	0.3	1.0	0.0	-0.1	-0.6	1.0	-0.5	0.2
Mean time to correctly identify matches	0.2	0.4	1.2	0.7	1.1	-0.2	0.4	0.0	0.6
Comparative height size at age 10	0.2	0.9	3.4	-0.4	-0.1	0.8	0.5	1.9	1.0
Suffer from ‘nerves’	0.2	0.3	0.8	0.7	-0.9	-0.1	-0.4	0.4	-0.0
Overall health rating	0.2	0.4	1.5	-0.1	-0.2	-1.0	-1.2	0.2	-0.2
Supplements: Vitamin C	0.2	0.2	0.5	0.1	0.2	0.6	-0.7	0.5	-0.2
Mood swings	0.2	0.3	0.8	0.9	-0.0	0.3	-0.7	-0.3	0.4
Long-standing illness, disability or infirmity	0.2	0.3	1.1	0.2	1.1	0.5	0.0	-0.1	0.4
Medication for cholesterol	0.2	0.3	0.7	0.5	-0.8	-0.2	-0.7	-0.5	-0.1
Number of self-reported non-cancer illnesses	0.2	0.4	2.0	-1.4	0.1	0.4	-0.3	0.2	0.5
Commuting to job workplace: Public transport	0.2	0.3	0.5	0.4	0.7	0.5	-0.4	0.4	0.5
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.6	0.3	-0.0	0.1	-0.7	-0.8	-0.7
Medication: Bendroflumethiazide	0.2	0.3	1.0	0.3	1.0	-0.7	0.3	0.1	-0.5
Alcohol drinker status: Never	0.2	0.2	1.0	-0.4	-0.1	-1.0	0.1	0.2	-0.1
Ever smoked	0.2	0.4	0.9	-0.8	-0.4	-0.8	-0.9	-0.1	-0.1
Irritability	0.2	0.3	0.7	-0.5	-0.1	0.8	-0.9	-0.0	0.6
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.6	0.5	0.8	0.1	-0.1	-0.0	-0.5
Pain experienced in last month	0.2	0.4	0.8	0.1	-0.4	0.4	0.8	0.9	0.6
Blood Platelet Count	0.1	1.0	4.1	-0.4	-0.4	-0.2	-0.3	-2.0	-1.3
Tanning	0.1	1.7	4.4	1.5	-1.2	0.5	2.1	1.2	0.8
Diabetes (mother)	0.1	0.1	0.5	0.2	0.7	0.1	0.2	0.3	-0.1
Past tobacco smoking	0.1	0.2	0.5	0.3	0.7	0.3	0.7	-0.5	0.0
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.4	0.0	-0.2	0.3	-0.6	0.2	0.7
Qualifications: None of the above	0.1	0.3	1.4	-0.0	-0.3	-1.2	0.0	-0.1	0.4
Length of working week for main job	0.1	0.1	0.2	-0.0	-0.0	-0.1	-0.4	-0.3	0.4
Leg pain on walking	0.1	0.1	0.2	-0.2	-0.0	0.2	-0.5	-0.1	-0.4
Medication: Aspirin	0.1	0.2	0.5	-0.1	0.6	-0.7	0.1	-0.5	-0.2
Friendships satisfaction	0.1	0.2	0.4	0.6	-0.3	0.2	0.4	0.5	-0.1
Breast cancer (self-reported)	0.1	0.1	0.5	0.7	-0.1	0.1	0.1	0.3	0.1
Medication: Aspirin	0.1	0.2	0.4	-0.2	0.5	-0.7	-0.0	-0.6	-0.3
Average weekly champagne plus white wine intake	0.1	0.2	0.5	0.1	0.7	0.3	0.3	-0.2	0.5
Mother’s age at death	0.1	0.2	0.4	0.4	0.3	0.5	0.6	0.1	-0.2
Medication: Lisinopril	0.1	0.2	0.6	-0.1	0.8	0.5	-0.1	0.2	0.3
Unable to work because of sickness or disability	0.1	0.2	0.6	0.0	-0.0	-0.8	-0.2	-0.3	-0.5
Hair Pigment	0.0	0.1	0.5	-0.0	-0.2	0.1	-0.3	-0.3	-0.7
Tense / ‘highly strung’	0.0	0.1	0.2	0.2	0.5	0.1	0.1	0.1	-0.4

Hub : Genes

DNAJC16

Models

Trait associations