Hub : Genes

DNAL1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Cells Transformed fibroblasts 0.114 0.040 0.00015 0.002 NA 0.009 NA 0.009 0.2100 NA 0.0600 NA 0.0670
2 TCGA Thyroid Carcinoma 0.035 0.017 0.00070 0.024 0.017 0.019 NA 0.018 0.0018 0.0079 0.0048 NA 0.0062

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.3 0.4 0.9 0.9 -0.0
Bipolar Disorder or Schizophrenia 0.6 1.5 1.9 1.4 -1.1
Depressed Affect (Nagel 2018) 0.3 0.5 1.0 1.0 0.3
Depression (Nagel 2018) 0.1 0.2 0.3 0.5 -0.0
Intelligence (Savage-Jansen 2018) 2.9 8.9 15.4 3.9 -1.6
Neuroticism (Nagel 2018) 1.0 2.3 3.4 1.9 -1.1
Schizophrenia (2018) 0.7 1.5 2.1 1.0 -1.4
Schizophrenia vs Biploar Disorder 1.7 2.2 3.3 -1.8 1.0
Worry (Nagel 2018) 0.4 0.8 1.6 1.3 -0.1
Alzheimer’s Disease (in mother) 2.1 2.5 4.4 0.8 -2.1
Alzheimer’s Disease (in father) 0.9 0.9 1.9 -1.4 0.1
Alzheimer’s Disease (including proxy) 0.5 0.7 1.4 0.0 -1.2
Crohns Disease (2017) 0.5 1.1 1.2 1.0 -1.1
Irritable Bowel Disease (IBD) 0.4 0.9 1.8 1.3 0.1
Ulcerative Colitis (UC) 0.6 1.2 1.5 1.0 1.2
Major Depression (MDD) 2.0 2.4 3.9 0.9 -2.0
Reaction Time 0.3 0.6 0.7 -0.8 0.7
Verbal and Numeric Reasoning (VNR) 1.1 2.6 5.0 2.2 -0.5
Breast Cancer 0.1 0.3 0.4 -0.6 0.6
Ovarian Cancer 3.5 4.6 7.2 -1.5 2.7
Prostate Cancer 0.5 0.7 1.3 -1.1 0.4
Age at First Birth 2.4 3.4 4.0 2.0 -1.7
Bipolar Disorder (2011) 0.5 0.4 0.9 0.9 -0.0
Body Mass Index (BMI) (2010) 0.3 0.4 0.6 -0.8 0.5
Coronary Artery Disease (CAD) 0.1 0.2 0.2 -0.4 -0.4
Crohns Disease (2012) 0.3 0.4 0.5 0.7 -0.6
Mean Putamen Volume 1.0 1.1 2.0 -1.4 0.5
Fasting Glucose 0.8 1.0 1.6 1.3 0.5
HbA1C 0.5 0.5 0.9 0.4 0.9
HDL Cholesterol 4.3 7.2 9.5 -2.2 3.1
LDL Cholesterol 1.7 2.7 2.9 1.6 -1.7
Lupus 1.3 1.9 3.9 0.2 -2.0
Neuroticism (2016) 0.1 0.2 0.3 -0.1 -0.5
Primary Biliary Cirrhosis 1.7 2.4 4.1 -0.8 2.0
Rheumatoid Arthritis 1.9 2.6 3.3 1.8 -1.4
Schizophrenia (2014) 0.2 0.3 0.6 0.2 -0.8
Triglycerides 0.6 1.0 1.9 -1.4 -0.3
Type 2 Diabetes (T2D) (2012) 0.6 0.7 0.9 -0.9 0.7
Ulcerative Colitis 1.4 2.0 4.0 -0.2 2.0
Blood Eosinophil Count 0.2 1.5 2.4 0.7 -1.6
Blood Platelet Count 0.5 6.3 11.9 -0.8 3.5
Blood Red Count 3.5 33.9 46.2 -6.8 4.6
Blood White Count 0.1 0.7 1.4 -0.1 -1.2
Heel T-Score 0.2 2.0 3.5 0.7 -1.9
BMI 0.9 4.9 9.3 -3.1 0.8
Height 0.3 6.5 12.8 3.6 -0.5
Waist Hip Ratio (WHR) 0.0 0.2 0.4 -0.6 0.0
Systolic Blood Pressure 4.6 23.2 31.1 -3.9 5.6
Smoking Status 0.4 1.0 1.7 1.3 -0.5
Allergy or Eczema 1.5 3.9 7.8 0.2 2.8
Cardiovascular Disease 0.2 0.5 1.0 -0.2 -1.0
Hypothyroidism (self reported) 0.9 2.1 3.2 1.0 -1.8
Respiratory disease 0.8 1.8 2.5 -1.1 1.6
Type 2 Diabetes (T2D) (2018) 1.1 2.0 3.8 -1.9 -0.5
Lung FEV1/FVC ratio 0.5 2.4 4.0 0.9 -2.0
Lung FVC 0.0 0.2 0.4 -0.6 -0.0
Neuroticism 0.0 0.1 0.2 0.2 -0.4
Chronotype (morning person) 0.3 0.8 1.1 1.0 -0.7
Hair Pigment 0.0 1.3 2.5 -0.5 -1.6
Tanning 0.2 1.9 3.2 1.8 -0.8
Hand grip strength (left) 0.4 0.9 1.7 0.4 1.3
Number of treatments/medications taken 0.1 0.2 0.3 -0.5 0.3
Average weekly spirits intake 1.6 2.0 3.7 -1.9 0.6
Sensitivity / hurt feelings 0.7 1.2 1.8 0.8 -1.3
Frequency of depressed mood in last 2 weeks 0.2 0.2 0.2 -0.5 -0.5
Hearing difficulty/problems: Yes 1.5 2.3 3.6 1.9 -1.0
Relative age of first facial hair 0.4 0.7 1.3 1.1 -0.4
Other serious medical condition/disability diagnosed by doctor 1.1 1.4 2.0 -1.4 0.9
Ever used hormone-replacement therapy (HRT) 0.3 0.3 0.7 -0.8 0.1
Ever had hysterectomy (womb removed) 2.4 2.7 4.9 -2.2 0.6
Systolic blood pressure, automated reading 6.0 17.3 18.2 -4.3 4.1
Eye problems/disorders: Diabetes related eye disease 0.5 0.6 1.0 0.4 -1.0
Angina 0.2 0.2 0.4 0.3 -0.6
Medication for hormone replacement therapy 1.9 2.1 3.3 -1.0 1.8
Vitamin and mineral supplements 3.1 4.2 6.6 -2.6 1.4
Supplements: Zinc 1.7 1.9 2.0 1.4 -1.3
Medication: Co-codamol 1.7 2.0 3.8 -2.0 0.3
Medication: Metformin 0.5 0.7 1.4 -1.2 0.1
Diabetes (father) 0.5 0.6 0.8 -0.9 -0.6
Diabetes (mother) 0.3 0.4 0.4 -0.6 0.6
Severe depression (siblings) 0.1 0.2 0.3 0.6 0.0
Pack years adult smoking proportion 0.6 0.8 1.5 -1.2 0.4
Impedance of leg (right) 0.7 3.5 5.7 2.4 -1.2
Leg fat-free mass (left) 0.2 1.2 1.8 -1.3 0.7
Trunk fat percentage 0.3 1.2 2.1 -1.4 -0.6
Hand grip strength (right) 0.9 2.6 4.7 0.6 2.2
Townsend deprivation index at recruitment 2.9 4.1 8.0 -2.8 0.5
Current tobacco smoking 0.5 0.8 1.4 -1.2 -0.4
Average weekly fortified wine intake 0.6 0.7 1.4 1.2 -0.1
Maternal smoking around birth 0.5 0.7 0.7 -0.9 0.8
Fed-up feelings 0.2 0.4 0.5 -0.6 0.7
Frequency of unenthusiasm / disinterest in last 2 weeks 0.1 0.1 0.2 -0.2 0.4
Relative age voice broke 0.1 0.1 0.1 0.4 0.1
Taking other prescription medications 0.2 0.4 0.7 -0.8 -0.0
Age when periods started (menarche) 3.3 7.9 10.2 2.4 -3.2
Bilateral oophorectomy (both ovaries removed) 4.9 5.7 6.5 -2.2 2.5
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.3 2.5 -0.2 -1.6
Tinnitus: Yes, but not now, but have in the past 0.4 0.5 0.8 -0.4 0.9
Qualifications: CSEs or equivalent 0.4 0.5 1.0 -0.1 1.0
Serious illness, injury or assault to yourself 0.1 0.1 0.2 -0.1 -0.4
High blood pressure 0.1 0.4 0.7 -0.8 0.1
Hayfever, allergic rhinitis or eczema 0.6 1.3 2.4 0.4 1.6
Multivitamins +/- minerals 2.6 3.3 4.9 2.2 -1.4
Stomach or abdominal pain in last month 1.6 2.0 2.9 -1.7 1.1
Supplements: Glucosamine 2.0 2.7 2.8 1.6 -1.7
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 0.3 -0.6 0.4
Medication: Atenolol 0.1 0.1 0.3 0.5 0.1
Medication: Levothyroxine sodium 0.5 0.8 1.3 0.5 -1.1
Sitting height 0.1 1.0 1.1 1.0 1.0
Chronic bronchitis/emphysema (father) 0.5 0.5 1.0 -0.2 1.0
High blood pressure (mother) 0.4 0.6 1.1 -0.4 1.0
Body mass index (BMI) 1.2 5.0 9.6 -3.1 0.6
Impedance of leg (left) 0.5 2.3 4.1 2.0 -0.8
Leg predicted mass (left) 0.2 1.3 1.9 -1.4 0.8
Trunk fat mass 0.3 1.4 2.7 -1.6 -0.3
Waist circumference 1.1 3.9 7.1 -2.7 0.8
Number of incorrect matches in round 0.9 1.5 1.8 1.1 -1.3
Past tobacco smoking 0.6 1.1 2.3 -1.5 0.0
Alcohol usually taken with meals 0.3 0.4 0.7 0.8 0.5
Nervous feelings 0.3 0.5 0.9 0.2 1.0
Frequency of tenseness / restlessness in last 2 weeks 0.0 0.0 0.1 0.3 -0.2
Hearing difficulty/problems with background noise 2.9 4.6 5.6 1.9 -2.4
Hair/balding pattern: Pattern 2 1.7 2.2 3.7 0.8 -1.9
Had menopause 0.3 0.4 0.6 0.5 -0.8
Had other major operations 1.9 2.4 4.7 -2.2 -0.2
Forced vital capacity (FVC) 0.4 1.4 2.8 1.7 -0.1
Heel bone mineral density (BMD) T-score, automated (right) 0.4 1.0 2.0 -0.1 -1.4
Ever unenthusiastic/disinterested for a whole week 1.3 1.6 1.8 -1.2 1.3
Qualifications: None of the above 4.5 9.6 16.1 -4.0 1.8
Financial difficulties in last 2 years 5.0 6.7 11.2 -3.4 1.5
Mouth/teeth dental problems 1.9 2.9 4.0 1.3 -2.0
Heart attack 1.1 1.4 2.5 0.6 -1.6
Allergy 0.6 1.4 2.7 0.2 -1.7
Pain all over the body in last month 2.2 2.4 3.7 -1.9 1.0
Diabetes (self-reported) 1.0 1.6 3.2 -1.8 -0.1
Hayfever/allergic rhinitis (self-reported) 2.2 2.9 5.4 2.3 -0.6
Medication: Ramipril 0.2 0.3 0.3 -0.5 0.5
Medication: Simvastatin 0.4 0.6 1.0 -0.4 -1.0
Fluid intelligence score 1.0 2.1 4.1 2.0 -0.1
Illnesses of siblings 0.0 0.0 0.0 0.1 -0.1
Neuroticism score 0.3 0.7 0.7 0.9 -0.8
Weight 0.4 2.0 3.9 -2.0 0.4
Impedance of arm (right) 2.6 12.0 19.9 4.5 -2.0
Arm fat percentage (right) 0.4 1.6 2.9 -1.7 -0.5
Trunk fat-free mass 0.2 1.4 2.1 -1.4 0.8
Hip circumference 0.3 1.4 2.7 -1.6 0.2
Time employed in main current job 0.7 0.8 1.4 1.2 -0.4
Alcohol intake versus 10 years previously 2.4 3.6 6.9 -2.6 0.5
Father’s age at death 0.8 1.1 1.5 0.9 -1.2
Worrier / anxious feelings 2.9 5.4 7.4 1.8 -2.7
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.8 1.6 -1.2 -0.3
Falls in the last year 1.8 2.5 3.5 -1.9 1.2
Hair/balding pattern: Pattern 3 0.1 0.2 0.3 -0.3 -0.6
Number of live births 2.2 3.1 4.4 -2.1 1.3
Forced expiratory volume in 1-second (FEV1) 0.3 0.9 1.7 1.3 -0.2
Pulse rate 0.1 0.2 0.4 0.4 -0.6
Happiness 1.5 1.8 2.7 1.6 -1.0
Noisy workplace 2.1 2.6 3.2 -1.4 1.8
Qualifications: A levels/AS levels or equivalent 1.6 3.6 5.6 2.4 -1.2
Serious illness, injury or assault of a close relative in last 2 years 1.9 2.2 4.3 -2.1 0.3
Mouth/teeth dental problems: Dentures 0.0 0.0 0.0 0.2 0.0
Asthma 0.4 0.9 1.6 -0.4 1.3
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.7 1.3 -1.1 0.3
Medication: Cholesterol lowering 0.8 1.3 2.1 0.7 -1.4
Depression (self-reported) 0.4 0.5 0.8 0.4 -0.9
Medication: Lansoprazole 1.5 1.7 3.4 0.2 -1.9
Prospective memory result 1.3 1.6 3.1 -1.8 0.4
Lung cancer (father) 0.7 0.8 1.4 -1.2 0.3
Illnesses of mother 0.9 1.2 1.3 -1.0 1.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.7 2.2 3.7 1.9 -0.8
Pulse wave Arterial Stiffness index 0.7 0.9 1.0 0.9 1.0
Impedance of arm (left) 2.1 9.8 16.8 4.1 -1.7
Arm fat mass (right) 0.6 2.6 5.2 -2.3 0.0
Trunk predicted mass 0.3 1.4 2.1 -1.4 0.9
Standing height 0.3 2.8 5.4 2.3 -0.4
Length of working week for main job 0.4 0.5 0.6 -0.8 0.6
Exposure to tobacco smoke at home 5.1 5.7 5.9 -2.4 2.4
Breastfed as a baby 2.2 2.8 3.0 1.7 -1.6
Tense / ‘highly strung’ 1.2 1.9 2.0 1.4 -1.4
Seen doctor (GP) for nerves, anxiety, tension or depression 2.3 3.5 4.7 2.2 -1.5
Hair/balding pattern: Pattern 4 0.5 1.2 2.0 -0.7 1.4
Birth weight of first child 0.6 1.1 1.2 1.1 -1.0
Peak expiratory flow (PEF) 0.3 0.8 1.2 0.6 1.1
Pulse wave reflection index 0.9 1.1 2.0 1.4 0.6
Ever highly irritable/argumentative for 2 days 0.3 0.4 0.7 0.8 -0.2
Loud music exposure frequency 1.4 1.5 2.0 1.4 1.0
Qualifications: O levels/GCSEs or equivalent 2.3 3.6 6.7 2.6 -0.7
Mouth/teeth dental problems: Bleeding gums 2.5 3.3 4.2 -1.5 2.1
Blood clot in the leg (DVT) 0.3 0.4 0.8 -0.9 -0.3
Medication: Paracetamol 0.7 1.2 2.0 -1.4 -0.6
Headache pain in last month 0.8 1.5 2.4 -0.7 1.5
Medication for cholesterol, blood pressure or diabetes 0.3 0.4 0.9 -0.2 0.9
Glaucoma (self-reported) 0.2 0.3 0.3 0.5 0.5
Gout (self-reported) 0.0 0.1 0.1 -0.3 -0.1
Hypothyroidism/myxoedema (self-reported) 0.8 1.5 2.8 0.6 -1.7
Medication: Amlodipine 2.1 2.9 3.2 -1.8 1.6
Medication: Ventolin 100micrograms inhaler 2.3 3.0 4.4 -1.3 2.1
Birth weight 1.1 2.3 3.2 1.8 -1.2
Chronic bronchitis/emphysema (mother) 0.5 0.6 1.1 -0.0 1.0
High blood pressure (siblings) 0.3 0.4 0.5 0.7 -0.5
Forced vital capacity (FVC), Best measure 0.8 2.8 5.1 2.3 -0.7
Body fat percentage 0.4 1.6 3.0 -1.7 -0.5
Leg fat percentage (right) 0.5 1.8 3.5 -1.9 -0.3
Arm fat-free mass (right) 0.4 2.3 4.2 -2.0 0.6
Exposure to tobacco smoke outside home 0.7 0.9 1.8 -1.3 0.0
Comparative body size at age 10 1.3 3.5 3.5 -1.9 1.8
Number of full brothers 0.7 0.9 1.6 -0.4 -1.2
Worry too long after embarrassment 0.5 0.8 1.7 0.1 -1.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.3 0.6 0.8 -0.0
Wheeze or whistling in the chest in last year 1.2 2.2 3.9 -0.7 2.0
Number of children fathered 0.4 0.5 0.8 -0.9 0.3
Reason for reducing amount of alcohol drunk: Health precaution 0.1 0.1 0.2 0.4 0.1
Age at first live birth 1.0 1.8 2.3 1.5 -1.1
Pulse wave peak to peak time 0.6 0.7 1.1 -0.6 -1.1
Health satisfaction 3.9 5.0 7.2 -1.7 2.7
Shortness of breath walking on level ground 0.6 0.7 1.3 0.0 -1.2
Qualifications: College or University degree 1.9 5.8 9.8 3.1 -1.4
Eye problems/disorders: None of the above 0.7 0.8 0.9 0.9 -0.8
Mouth/teeth dental problems: Loose teeth 0.2 0.3 0.4 0.5 -0.6
Emphysema/chronic bronchitis 3.5 3.9 6.4 -2.5 1.2
Medication for pain relief, constipation, heartburn 1.5 2.6 5.2 2.3 -0.1
Neck or shoulder pain in last month 2.8 4.0 5.1 -2.3 1.7
Medication: Blood pressure 0.2 0.4 0.7 -0.3 -0.9
Angina (self-reported) 0.2 0.3 0.5 0.3 -0.7
Migraine (self-reported) 0.4 0.5 0.9 1.0 -0.4
Medication: Ibuprofen 0.2 0.2 0.4 -0.6 0.3
Medication: Allopurinol 0.8 1.0 1.2 -1.1 -0.9
Medication: Omeprazole 0.1 0.1 0.1 -0.4 -0.1
Medication: Seretide 50 evohaler 0.2 0.3 0.5 0.7 -0.2
Mean time to correctly identify matches 0.2 0.4 0.7 -0.8 0.3
Heart disease (mother) 1.2 1.4 1.7 1.1 -1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.6 1.9 3.8 0.1 1.9
Whole body fat mass 0.5 2.2 4.3 -2.1 0.0
Leg fat mass (right) 0.4 1.6 3.1 -1.8 -0.1
Arm predicted mass (right) 0.5 2.6 4.8 -2.2 0.6
Pulse rate, automated reading 0.1 0.4 0.6 -0.8 0.4
Alcohol intake frequency. 2.0 4.7 9.3 -3.0 0.4
Comparative height size at age 10 0.0 0.2 0.2 0.4 -0.4
Number of full sisters 1.5 1.8 3.6 0.3 -1.9
Suffer from ‘nerves’ 0.4 0.6 1.0 1.0 0.5
Overall health rating 1.0 2.1 4.1 -2.0 0.3
Chest pain or discomfort 0.3 0.5 0.9 -0.9 -0.3
Had major operations 0.4 0.4 0.8 -0.9 -0.1
Age at last live birth 0.1 0.2 0.3 0.5 0.2
Family relationship satisfaction 1.7 2.0 3.6 1.9 -0.7
Leg pain on walking 0.7 0.8 1.2 -1.1 0.7
Qualifications: NVQ or HND or HNC or equivalent 0.5 0.6 1.1 1.1 0.1
Commuting to job workplace: Car/motor vehicle 0.2 0.2 0.4 0.6 -0.2
Illness, injury, bereavement, stress in last 2 years 3.2 3.9 7.2 2.7 -0.7
Medication: Aspirin 0.7 0.9 1.5 -1.2 -0.6
Supplements: Vitamin C 1.3 1.5 2.7 1.6 -0.6
Knee pain experienced in last month 0.2 0.4 0.7 -0.8 0.2
Hypertension (Self-reported) 0.2 0.6 1.0 -1.0 0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.9 1.1 2.1 0.2 -1.4
Illnesses of father: Heart disease 1.6 2.3 3.6 1.9 -1.0
Illnesses of siblings: Diabetes 2.2 2.6 5.3 -2.3 0.1
Smoking status: Previous 1.1 1.7 3.3 1.8 0.3
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.8 1.6 0.3 1.3
Whole body fat-free mass 0.3 1.5 2.4 -1.5 0.8
Leg fat-free mass (right) 0.3 1.8 2.5 -1.6 1.0
Arm fat percentage (left) 0.4 1.6 3.0 -1.7 -0.5
Average weekly red wine intake 0.5 0.7 1.2 1.1 -0.4
Handedness (chirality/laterality): Left-handed 2.5 3.0 3.2 1.6 -1.8
Mood swings 0.4 0.7 0.9 0.9 -0.8
Loneliness, isolation 1.1 1.5 2.0 1.4 -1.0
Long-standing illness, disability or infirmity 5.0 7.7 11.1 -3.3 2.1
Ever had bowel cancer screening 0.4 0.4 0.6 -0.8 -0.5
Diabetes diagnosed by doctor 0.8 1.3 2.6 -1.6 -0.3
Ever had stillbirth, spontaneous miscarriage or termination 4.8 5.1 6.8 -2.6 1.9
Friendships satisfaction 2.3 2.8 4.5 2.1 -1.1
Qualifications: nursing, teaching 3.8 5.8 8.6 2.9 -1.8
Commuting to job workplace: Walk 0.6 0.6 0.8 0.7 -0.9
Eye problems/disorders: Cataract 0.0 0.0 0.1 0.1 -0.3
Mouth/teeth dental problems: Mouth ulcers 0.8 1.3 1.9 -1.4 0.9
Medication for cholesterol 0.7 1.0 1.1 0.9 -1.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.0 0.0 0.0 -0.1 -0.1
Back pain experienced in last month 2.8 4.1 6.9 -2.6 1.1
Mineral and other dietary supplements 3.2 4.3 4.3 -2.1 2.1
Breast cancer (self-reported) 1.1 1.3 2.0 -1.4 0.8
Asthma (self-reported) 0.5 1.0 1.9 -0.3 1.4
Osteoporosis (self-reported) 0.5 0.6 1.2 0.0 1.1
Osteoarthritis (self-reported) 0.7 0.9 1.7 -1.3 -0.3
Medication: Aspirin 0.8 1.0 1.8 -1.4 -0.5
Medication: Gliclazide 0.5 0.5 0.9 -0.9 -0.4
Illnesses of father: None of the above (group 1) 0.8 1.0 1.4 -0.8 1.2
Smoking status: Current 0.3 0.5 0.9 -1.0 -0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.7 1.4 2.6 1.6 -0.4
Whole body water mass 0.3 1.6 2.6 -1.6 0.7
Leg predicted mass (right) 0.3 1.8 2.5 -1.6 1.0
Arm fat mass (left) 0.5 2.2 4.3 -2.1 -0.2
Number of self-reported non-cancer illnesses 0.5 0.8 0.8 -0.9 -0.9
Average weekly champagne plus white wine intake 1.5 2.0 2.7 -1.6 1.2
Miserableness 0.3 0.5 1.0 1.0 0.1
Guilty feelings 1.7 2.5 3.6 1.9 -1.2
Wears glasses or contact lenses 1.3 1.5 2.2 -0.9 1.5
Ever taken oral contraceptive pill 0.8 0.9 1.1 -0.8 1.1
Hearing aid user 0.1 0.1 0.2 0.3 0.4
Mother’s age at death 0.6 0.8 1.1 0.7 -1.0
Financial situation satisfaction 2.3 2.8 4.2 -2.1 1.2
Tinnitus: Yes, now most or all of the time 0.4 0.5 0.5 0.6 -0.7
Commuting to job workplace: Public transport 0.1 0.1 0.2 0.0 0.4
Eye problems/disorders: Glaucoma 0.7 0.9 1.6 0.3 1.3
Medication: Blood pressure 0.6 1.1 2.2 -0.3 1.5
Pain type(s) experienced in last month: Hip pain 0.9 1.1 1.8 -0.6 -1.4
Supplements: Fish oil (including cod liver oil) 2.6 3.3 3.7 1.7 -1.9
High cholesterol (Self-reported) 0.1 0.2 0.3 0.2 -0.6
Medication: Bendroflumethiazide 0.5 0.8 1.3 -0.5 1.1
Medication: Paracetamol 0.2 0.4 0.7 -0.8 -0.0
Medication: Lisinopril 0.8 1.0 2.0 -1.4 0.0
Medication: Atorvastatin 0.0 0.0 0.0 -0.1 -0.2
Illnesses of father: High blood pressure 0.2 0.2 0.5 -0.2 0.7
Alcohol drinker status: Never 1.4 1.7 3.4 -1.8 0.3
Ever smoked 0.6 1.0 1.2 1.1 -0.8
Basal metabolic rate 0.4 2.1 3.6 -1.9 0.8
Leg fat percentage (left) 0.6 2.3 4.5 -2.1 -0.1
Arm fat-free mass (left) 0.6 2.8 5.2 -2.3 0.7
Number of operations (self-reported) 2.2 3.3 6.5 -2.6 0.4
Average weekly beer plus cider intake 0.4 0.5 1.0 1.0 -0.2
Irritability 0.6 1.0 1.1 0.9 -1.1
Risk taking 0.8 1.2 1.8 -0.8 1.3
Ever had prostate specific antigen (PSA) test 0.1 0.1 0.1 -0.3 0.3
Fractured/broken bones in last 5 years 0.3 0.5 0.7 0.9 0.4
Age started oral contraceptive pill 0.7 0.9 1.7 0.5 -1.3
Diastolic blood pressure, automated reading 1.3 3.9 4.2 -1.9 2.1
Ever depressed for a whole week 0.4 0.4 0.5 0.7 0.7
Unable to work because of sickness or disability 0.5 0.6 1.2 -1.1 0.2
Commuting to job workplace: Cycle 4.9 5.9 7.5 2.7 -2.1
Myopia 0.1 0.1 0.2 0.2 0.4
Vascular/heart problems diagnosed by doctor 0.1 0.4 0.8 0.9 0.0
Cholesterol lowering medication 0.9 1.3 2.3 -1.5 0.5
Medication: Omeprazole (e.g. Zanprol) 0.1 0.1 0.1 -0.3 -0.4
Pain experienced in last month 2.3 3.8 4.9 2.2 -1.6
Supplements: Calcium 0.3 0.3 0.5 0.7 -0.3
Basal cell carcinoma (self-reported) 0.3 0.4 0.7 0.2 -0.9
Heart attack/myocardial infarction (self-reported) 1.1 1.4 2.4 0.6 -1.6
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 0.6 -0.8 -0.5
Heart disease (siblings) 0.2 0.3 0.6 0.2 0.8
Alcohol drinker status: Previous 0.4 0.5 0.9 -1.0 0.3
Pack years of smoking 0.4 0.6 1.2 -1.1 0.1
Impedance of whole body 1.3 6.5 11.5 3.4 -1.2
Leg fat mass (left) 0.5 1.8 3.7 -1.9 0.0
Arm predicted mass (left) 0.6 3.0 5.4 -2.3 0.8