Hub : Genes

NEK9

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.0530	0.0270	7.2e-03	0.058	NA	0.042	NA	0.019	3.8e-04	NA	0.00230	NA	2.9e-02
2	GTEx	Cells Transformed fibroblasts	0.0660	0.0250	1.4e-04	0.082	NA	0.047	NA	0.057	1.0e-06	NA	0.00020	NA	4.6e-05
3	GTEx	Esophagus Mucosa	0.1340	0.0440	6.4e-06	0.068	NA	0.044	NA	0.055	2.4e-05	NA	0.00061	NA	1.4e-04
4	TCGA	Kidney Renal Clear Cell Carcinoma	0.0201	0.0175	6.4e-03	0.019	0.017	-0.002	NA	0.000	3.1e-03	0.0046	0.63000	NA	3.0e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.8	1.2	1.7	0.8	1.1	-1.2	-1.3
Bipolar Disorder or Schizophrenia	1.3	3.1	3.6	1.6	1.8	-1.9	-1.8
Depressed Affect (Nagel 2018)	3.9	8.3	9.4	-2.5	-3.0	2.9	3.1
Depression (Nagel 2018)	0.2	0.3	0.9	-0.1	-0.5	0.9	0.5
Intelligence (Savage-Jansen 2018)	1.3	3.9	4.5	1.7	2.0	-2.1	-2.1
Neuroticism (Nagel 2018)	4.4	10.4	11.6	-3.0	-3.2	3.3	3.4
Schizophrenia (2018)	1.0	2.0	2.4	1.4	1.4	-1.5	-1.3
Schizophrenia vs Biploar Disorder	0.0	0.1	0.2	-0.1	-0.0	-0.4	0.2
Worry (Nagel 2018)	4.4	9.3	10.0	-3.0	-3.0	3.0	3.2
Alzheimer’s Disease (in mother)	0.0	0.0	0.1	0.3	0.1	-0.1	-0.1
Alzheimer’s Disease (in father)	0.0	0.0	0.0	-0.1	-0.2	-0.1	0.2
Alzheimer’s Disease (including proxy)	0.1	0.1	0.3	0.6	0.1	0.1	-0.0
Crohns Disease (2017)	0.3	0.7	1.7	-1.3	-0.8	0.3	0.6
Irritable Bowel Disease (IBD)	0.5	1.1	2.0	0.6	0.9	-1.4	-1.1
Ulcerative Colitis (UC)	2.4	4.5	5.5	2.0	2.1	-2.3	-2.1
Major Depression (MDD)	0.1	0.1	0.2	-0.4	-0.3	-0.0	0.3
Reaction Time	3.4	6.5	7.6	2.4	2.8	-2.3	-2.7
Verbal and Numeric Reasoning (VNR)	1.6	3.8	5.2	1.2	1.9	-2.3	-2.1
Breast Cancer	0.5	1.2	1.6	-1.3	-1.2	0.6	1.1
Ovarian Cancer	1.5	2.0	2.4	-1.5	-1.5	1.2	1.4
Prostate Cancer	1.5	2.0	2.6	-1.6	-1.5	1.0	1.5
Age at First Birth	4.1	6.0	6.4	-2.4	-2.4	2.5	2.4
Bipolar Disorder (2011)	1.1	1.1	1.9	0.9	0.9	-1.4	-0.9
Body Mass Index (BMI) (2010)	0.1	0.2	0.5	-0.7	-0.4	-0.1	0.3
Coronary Artery Disease (CAD)	7.8	9.3	10.7	-3.3	-3.2	2.7	3.0
Crohns Disease (2012)	0.9	1.4	2.4	-1.5	-1.2	1.0	1.0
Mean Putamen Volume	0.1	0.1	0.1	0.4	0.2	-0.1	-0.3
Fasting Glucose	0.1	0.1	0.3	0.4	0.2	-0.5	-0.1
HbA1C	0.8	0.8	1.5	0.7	0.8	-1.2	-0.9
HDL Cholesterol	0.1	0.1	0.2	0.2	0.4	-0.3	-0.3
LDL Cholesterol	0.6	0.9	1.3	0.8	1.1	-0.5	-1.1
Lupus	2.6	4.0	5.8	-1.5	-1.9	2.4	2.1
Neuroticism (2016)	0.3	0.5	0.9	-0.7	-0.7	0.0	0.9
Primary Biliary Cirrhosis	1.0	1.5	2.4	-1.6	-1.2	1.0	1.0
Rheumatoid Arthritis	6.4	8.7	11.8	3.4	3.0	-2.5	-2.9
Schizophrenia (2014)	0.2	0.5	1.3	0.3	0.6	-1.1	-0.3
Triglycerides	1.4	2.2	2.5	-1.6	-1.4	1.6	1.4
Type 2 Diabetes (T2D) (2012)	3.1	3.6	4.3	1.6	1.9	-1.9	-2.1
Ulcerative Colitis	0.1	0.1	0.4	0.2	0.1	-0.6	-0.2
Blood Eosinophil Count	0.1	0.8	1.4	1.2	0.7	-0.6	-0.9
Blood Platelet Count	1.5	17.3	18.0	4.2	4.2	-4.0	-4.2
Blood Red Count	0.4	4.3	5.6	2.4	2.2	-1.4	-2.1
Blood White Count	0.4	2.8	3.9	1.6	1.4	-2.0	-1.6
Heel T-Score	7.8	61.7	74.3	-8.6	-8.0	6.9	7.8
BMI	0.3	1.6	2.1	1.4	1.2	-1.2	-1.2
Height	1.8	35.4	41.0	5.3	5.9	-6.4	-6.1
Waist Hip Ratio (WHR)	0.4	1.9	2.7	1.6	1.5	-1.1	-1.2
Systolic Blood Pressure	6.3	31.4	36.1	-6.0	-5.8	4.8	5.7
Smoking Status	0.1	0.2	0.4	0.3	0.6	-0.5	-0.5
Allergy or Eczema	0.8	2.2	4.1	0.9	1.3	-2.0	-1.5
Cardiovascular Disease	1.3	4.4	5.3	-1.9	-2.2	2.0	2.3
Hypothyroidism (self reported)	5.3	12.2	14.2	-3.8	-3.5	3.1	3.5
Respiratory disease	0.1	0.2	0.5	0.7	0.5	-0.2	-0.3
Type 2 Diabetes (T2D) (2018)	0.0	0.0	0.0	0.0	-0.0	-0.1	0.1
Lung FEV1/FVC ratio	0.0	0.1	0.4	-0.0	0.3	0.0	-0.6
Lung FVC	0.8	4.2	5.7	2.4	2.2	-1.5	-2.0
Neuroticism	2.7	6.4	7.5	-2.4	-2.5	2.4	2.7
Chronotype (morning person)	0.2	0.4	0.8	-0.9	-0.7	0.3	0.5
Hair Pigment	0.1	2.3	2.7	-1.5	-1.5	1.6	1.5
Tanning	0.1	0.8	1.7	1.3	0.7	-0.8	-0.7
Hand grip strength (left)	1.1	2.9	4.6	-2.1	-1.8	0.7	1.8
Number of treatments/medications taken	3.0	5.3	6.6	-2.3	-2.3	2.1	2.6
Average weekly spirits intake	7.0	8.6	9.4	2.9	2.9	-3.1	-2.9
Sensitivity / hurt feelings	1.0	1.6	2.0	-1.0	-1.3	1.3	1.4
Frequency of depressed mood in last 2 weeks	0.3	0.4	0.6	-0.6	-0.7	0.5	0.8
Hearing difficulty/problems: Yes	6.5	9.9	12.1	3.5	3.1	-2.8	-3.1
Relative age of first facial hair	0.6	1.2	1.3	1.0	1.2	-1.0	-1.1
Other serious medical condition/disability diagnosed by doctor	0.0	0.0	0.0	0.1	-0.0	0.0	0.2
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.2	-0.3	-0.1	0.5	0.2
Ever had hysterectomy (womb removed)	0.1	0.1	0.2	0.3	0.4	-0.4	-0.4
Systolic blood pressure, automated reading	3.1	9.0	11.3	-3.4	-3.0	2.6	3.0
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.2	-0.5	-0.2	0.4	0.3
Angina	3.4	4.4	6.4	-2.5	-2.2	1.4	2.1
Medication for hormone replacement therapy	0.4	0.4	0.8	-0.9	-0.5	0.6	0.5
Vitamin and mineral supplements	0.4	0.6	0.9	-0.5	-0.7	0.9	0.8
Supplements: Zinc	1.1	1.2	2.3	0.7	1.0	-1.5	-1.0
Medication: Co-codamol	0.9	1.0	1.5	-0.7	-0.9	1.2	1.1
Medication: Metformin	0.6	0.8	1.8	-0.6	-0.7	1.3	0.8
Diabetes (father)	0.7	0.9	1.0	1.0	0.9	-1.0	-0.9
Diabetes (mother)	0.1	0.1	0.3	0.0	0.3	-0.6	-0.3
Severe depression (siblings)	1.3	1.4	1.7	-1.3	-1.3	0.9	1.3
Pack years adult smoking proportion	0.2	0.4	0.7	0.8	0.6	-0.4	-0.4
Impedance of leg (right)	2.8	13.4	14.5	-3.8	-3.4	3.8	3.7
Leg fat-free mass (left)	2.6	13.9	17.5	3.4	3.5	-4.2	-3.8
Trunk fat percentage	0.1	0.3	0.4	0.4	0.6	-0.5	-0.6
Hand grip strength (right)	0.8	2.2	3.4	-1.8	-1.6	0.5	1.6
Townsend deprivation index at recruitment	0.0	0.1	0.2	-0.1	-0.1	0.4	0.3
Current tobacco smoking	0.1	0.2	0.3	0.6	0.5	-0.5	-0.3
Average weekly fortified wine intake	1.7	2.0	2.1	-1.4	-1.4	1.4	1.4
Maternal smoking around birth	0.0	0.1	0.2	-0.1	-0.2	-0.4	0.2
Fed-up feelings	6.1	11.1	13.2	-3.3	-3.5	2.9	3.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.5	-0.5	-0.6	0.7	0.6
Relative age voice broke	0.1	0.2	0.3	0.4	0.4	-0.5	-0.5
Taking other prescription medications	2.4	3.7	4.4	-2.0	-1.8	1.7	2.1
Age when periods started (menarche)	0.4	1.1	1.2	-1.1	-1.0	1.1	1.0
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.4	0.0	0.3	-0.7	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	5.3	11.9	15.3	-3.9	-3.6	2.6	3.5
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.1	0.3	-0.3	0.3	0.4
Qualifications: CSEs or equivalent	0.0	0.0	0.1	0.4	0.0	0.0	0.0
Serious illness, injury or assault to yourself	1.2	1.4	2.5	1.0	1.0	-1.6	-1.0
High blood pressure	0.0	0.1	0.2	-0.1	-0.4	0.2	0.5
Hayfever, allergic rhinitis or eczema	1.5	3.3	5.3	1.3	1.6	-2.3	-1.9
Multivitamins +/- minerals	0.0	0.0	0.1	-0.3	-0.1	-0.3	0.1
Stomach or abdominal pain in last month	0.0	0.0	0.1	-0.2	0.0	-0.3	0.0
Supplements: Glucosamine	0.3	0.5	0.6	-0.8	-0.7	0.5	0.6
Diverticular disease/diverticulitis (self-reported)	2.9	3.5	3.9	2.0	1.9	-1.6	-1.9
Medication: Atenolol	3.8	4.8	5.4	-2.0	-2.2	2.3	2.2
Medication: Levothyroxine sodium	4.2	7.1	7.7	-2.8	-2.7	2.4	2.8
Sitting height	0.1	0.6	1.2	-1.1	-0.3	-1.1	-0.0
Chronic bronchitis/emphysema (father)	0.0	0.0	0.0	0.1	0.0	0.1	-0.0
High blood pressure (mother)	0.1	0.2	0.5	0.3	-0.2	0.7	0.3
Body mass index (BMI)	0.2	0.9	1.1	0.9	1.0	-0.8	-1.0
Impedance of leg (left)	3.0	14.6	15.5	-3.9	-3.6	3.9	3.9
Leg predicted mass (left)	2.6	13.6	16.8	3.4	3.4	-4.1	-3.7
Trunk fat mass	0.6	2.6	3.0	1.4	1.7	-1.7	-1.7
Waist circumference	1.4	5.1	5.5	2.3	2.3	-2.0	-2.4
Number of incorrect matches in round	0.1	0.2	0.3	-0.4	-0.4	0.4	0.6
Past tobacco smoking	0.3	0.5	1.2	1.1	0.5	-0.5	-0.6
Alcohol usually taken with meals	3.2	5.2	5.6	2.3	2.3	-2.2	-2.4
Nervous feelings	3.9	7.3	8.6	-2.7	-2.7	2.5	2.9
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.0	0.0	0.1	0.0	0.0	0.1
Hearing difficulty/problems with background noise	2.6	4.1	4.6	1.9	2.0	-2.2	-2.0
Hair/balding pattern: Pattern 2	0.1	0.1	0.2	-0.2	0.3	0.1	-0.4
Had menopause	0.1	0.1	0.2	0.5	0.5	-0.1	-0.3
Had other major operations	1.7	2.0	2.6	1.5	1.3	-1.6	-1.2
Forced vital capacity (FVC)	1.6	6.3	6.9	2.5	2.6	-2.3	-2.6
Heel bone mineral density (BMD) T-score, automated (right)	4.2	9.7	12.4	-3.5	-3.3	2.3	3.2
Ever unenthusiastic/disinterested for a whole week	3.4	4.2	4.7	-2.1	-2.1	1.8	2.2
Qualifications: None of the above	0.2	0.4	1.0	-0.3	-0.4	1.0	0.6
Financial difficulties in last 2 years	2.5	3.4	4.9	1.4	1.8	-2.2	-1.9
Mouth/teeth dental problems	0.3	0.5	1.1	-0.6	-0.5	1.1	0.3
Heart attack	1.6	2.0	2.5	-1.4	-1.4	1.2	1.6
Allergy	2.5	5.7	8.5	-2.1	-2.2	2.9	2.3
Pain all over the body in last month	0.8	0.8	1.3	1.2	0.9	-0.9	-0.7
Diabetes (self-reported)	0.5	0.8	1.0	-0.7	-0.8	0.9	1.0
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.5	0.5	0.4	-0.7	-0.6
Medication: Ramipril	0.9	1.1	1.6	-0.8	-1.2	1.0	1.2
Medication: Simvastatin	1.0	1.5	2.0	-1.4	-1.1	1.1	1.3
Fluid intelligence score	0.2	0.5	1.1	-0.0	0.5	-1.0	-0.8
Illnesses of siblings	0.1	0.2	0.3	0.6	0.4	-0.4	-0.3
Neuroticism score	2.1	4.4	5.6	-2.1	-2.1	1.8	2.4
Weight	1.4	6.9	8.0	2.4	2.5	-2.8	-2.8
Impedance of arm (right)	0.0	0.0	0.1	0.3	0.2	-0.1	-0.1
Arm fat percentage (right)	0.6	2.5	2.7	1.6	1.6	-1.5	-1.6
Trunk fat-free mass	2.0	11.5	14.1	3.1	3.2	-3.8	-3.5
Hip circumference	1.5	6.4	7.6	2.5	2.5	-2.3	-2.8
Time employed in main current job	0.8	1.0	1.4	-1.0	-0.7	1.2	1.0
Alcohol intake versus 10 years previously	1.7	2.5	3.1	1.6	1.8	-1.2	-1.7
Father’s age at death	2.0	2.7	3.4	1.7	1.8	-1.2	-1.8
Worrier / anxious feelings	1.2	2.2	2.7	-1.6	-1.6	1.1	1.6
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	1.1	1.1	1.0	-1.0	-1.0
Falls in the last year	2.8	3.7	4.5	2.1	1.9	-1.8	-1.9
Hair/balding pattern: Pattern 3	0.1	0.1	0.2	0.4	0.2	-0.4	-0.0
Number of live births	0.0	0.0	0.1	0.3	0.0	-0.2	-0.1
Forced expiratory volume in 1-second (FEV1)	1.3	4.5	5.2	2.0	2.2	-1.9	-2.3
Pulse rate	0.2	0.4	0.6	0.5	0.6	-0.8	-0.5
Happiness	0.2	0.2	0.4	-0.3	-0.6	0.4	0.7
Noisy workplace	0.0	0.0	0.1	0.1	0.3	0.0	-0.1
Qualifications: A levels/AS levels or equivalent	0.5	1.1	1.5	0.9	1.1	-0.9	-1.2
Serious illness, injury or assault of a close relative in last 2 years	1.8	2.0	2.6	1.1	1.5	-1.4	-1.6
Mouth/teeth dental problems: Dentures	0.1	0.2	0.3	0.4	0.5	-0.5	-0.4
Asthma	0.1	0.2	0.5	0.7	0.3	0.0	-0.1
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	0.9	0.4	0.6	-1.0	-0.6
Medication: Cholesterol lowering	0.4	0.7	0.9	-0.9	-0.8	0.6	0.9
Depression (self-reported)	0.0	0.0	0.0	0.2	0.1	-0.2	-0.1
Medication: Lansoprazole	0.2	0.2	0.5	-0.3	-0.3	0.7	0.4
Prospective memory result	0.4	0.5	0.6	0.5	0.8	-0.7	-0.8
Lung cancer (father)	0.0	0.0	0.1	0.0	-0.1	0.1	0.3
Illnesses of mother	1.8	2.2	3.3	1.0	1.4	-1.8	-1.6
Forced expiratory volume in 1-second (FEV1), Best measure	1.1	3.4	4.0	1.8	2.0	-1.6	-2.0
Pulse wave Arterial Stiffness index	0.2	0.3	0.5	0.7	0.4	-0.6	-0.3
Impedance of arm (left)	0.0	0.0	0.1	-0.1	-0.1	0.1	0.2
Arm fat mass (right)	0.6	2.6	2.9	1.5	1.6	-1.6	-1.7
Trunk predicted mass	2.0	11.4	14.1	3.1	3.2	-3.8	-3.5
Standing height	1.6	16.1	21.0	3.4	3.9	-4.6	-4.1
Length of working week for main job	0.3	0.3	0.6	-0.4	-0.8	0.3	0.7
Exposure to tobacco smoke at home	0.6	0.6	0.8	0.5	0.9	-0.9	-0.9
Breastfed as a baby	0.8	1.0	1.4	0.6	0.9	-1.2	-1.1
Tense / ‘highly strung’	0.0	0.0	0.1	-0.0	-0.2	0.1	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.0	0.1	0.1	0.1	-0.2	0.3	0.3
Hair/balding pattern: Pattern 4	0.6	1.5	2.3	1.1	1.0	-1.5	-1.1
Birth weight of first child	2.3	4.1	5.1	1.7	2.3	-1.9	-2.3
Peak expiratory flow (PEF)	0.3	0.6	1.0	-0.7	-0.6	1.0	0.6
Pulse wave reflection index	0.6	0.8	1.4	1.2	0.9	-0.5	-0.8
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.1	-0.3	-1.0	0.4	1.1
Loud music exposure frequency	0.7	0.7	1.2	0.8	0.7	-1.1	-0.8
Qualifications: O levels/GCSEs or equivalent	0.0	0.0	0.1	0.1	-0.1	-0.3	-0.0
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.7	-0.7	-0.6	0.5	0.8
Blood clot in the leg (DVT)	2.0	2.6	4.6	1.1	1.4	-2.1	-1.6
Medication: Paracetamol	0.7	1.1	1.5	-0.9	-1.2	0.9	1.2
Headache pain in last month	0.3	0.5	0.7	-0.5	-0.6	0.8	0.8
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	0.7	0.6	0.7	-0.5	-0.8
Glaucoma (self-reported)	1.3	1.5	2.3	0.9	1.5	-1.2	-1.3
Gout (self-reported)	2.0	2.7	3.1	-1.8	-1.7	1.5	1.7
Hypothyroidism/myxoedema (self-reported)	3.6	7.0	7.9	-2.8	-2.6	2.4	2.8
Medication: Amlodipine	7.6	10.6	12.1	-2.9	-3.3	3.3	3.5
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.3	0.1	-0.4	0.5	0.4
Birth weight	0.1	0.2	0.3	-0.4	-0.5	0.0	0.5
Chronic bronchitis/emphysema (mother)	0.0	0.0	0.2	-0.0	-0.0	0.4	0.1
High blood pressure (siblings)	0.5	0.7	0.8	-0.9	-0.8	0.8	0.8
Forced vital capacity (FVC), Best measure	1.8	6.5	7.0	2.6	2.6	-2.3	-2.6
Body fat percentage	0.0	0.0	0.1	-0.0	0.2	-0.1	-0.2
Leg fat percentage (right)	0.4	1.3	1.7	-1.3	-1.0	1.3	1.1
Arm fat-free mass (right)	0.9	4.6	6.3	1.8	1.9	-2.5	-2.2
Exposure to tobacco smoke outside home	0.1	0.1	0.2	0.1	-0.3	-0.1	0.5
Comparative body size at age 10	0.9	2.5	2.9	1.3	1.6	-1.7	-1.7
Number of full brothers	0.1	0.1	0.2	0.5	0.3	-0.2	-0.4
Worry too long after embarrassment	0.1	0.1	0.3	-0.5	-0.4	0.1	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	0.7	0.9	0.8	-0.9	-0.6
Wheeze or whistling in the chest in last year	0.3	0.5	0.8	-0.1	-0.7	0.9	0.9
Number of children fathered	1.9	2.2	2.5	-1.4	-1.4	1.6	1.5
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.9	-0.9	-0.3	0.5	0.3
Age at first live birth	0.0	0.0	0.1	0.3	0.1	-0.0	-0.2
Pulse wave peak to peak time	0.3	0.3	0.6	-0.8	-0.5	0.5	0.3
Health satisfaction	0.2	0.3	0.8	0.9	0.3	-0.6	-0.2
Shortness of breath walking on level ground	2.1	2.5	2.9	-1.5	-1.6	1.5	1.7
Qualifications: College or University degree	0.9	2.8	3.8	1.2	1.8	-1.9	-1.7
Eye problems/disorders: None of the above	1.2	1.4	1.9	-1.1	-1.4	0.9	1.3
Mouth/teeth dental problems: Loose teeth	0.4	0.4	0.5	-0.6	-0.7	0.7	0.7
Emphysema/chronic bronchitis	1.0	1.1	1.4	1.1	0.9	-1.2	-1.0
Medication for pain relief, constipation, heartburn	0.5	0.9	1.1	1.0	1.0	-0.8	-1.0
Neck or shoulder pain in last month	0.8	1.1	2.5	1.6	1.0	-0.4	-0.9
Medication: Blood pressure	1.3	2.3	3.1	-1.3	-1.6	1.4	1.8
Angina (self-reported)	3.0	3.9	5.9	-2.4	-2.0	1.3	2.0
Migraine (self-reported)	1.4	1.7	2.0	-1.3	-1.4	1.0	1.4
Medication: Ibuprofen	0.8	0.9	1.7	0.7	0.8	-1.3	-0.9
Medication: Allopurinol	3.4	4.6	5.5	-2.3	-2.1	1.8	2.2
Medication: Omeprazole	0.7	0.8	1.2	-0.3	-1.0	1.0	1.1
Medication: Seretide 50 evohaler	0.2	0.3	0.5	-0.2	-0.4	0.7	0.5
Mean time to correctly identify matches	4.4	8.4	9.8	2.8	3.1	-2.5	-3.1
Heart disease (mother)	8.3	10.1	11.1	-3.3	-3.2	3.0	3.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.2	-0.5	-0.0	-0.2	-0.0
Whole body fat mass	0.4	1.8	2.0	1.1	1.4	-1.4	-1.4
Leg fat mass (right)	0.2	0.6	0.8	0.7	0.8	-0.8	-0.9
Arm predicted mass (right)	0.9	4.4	6.0	1.8	1.9	-2.4	-2.2
Pulse rate, automated reading	0.0	0.1	0.1	-0.4	0.0	-0.3	0.1
Alcohol intake frequency.	1.7	4.0	4.3	2.0	1.9	-2.1	-2.0
Comparative height size at age 10	3.3	18.3	21.5	3.9	4.2	-4.6	-4.4
Number of full sisters	0.1	0.1	0.2	0.0	-0.4	-0.0	0.4
Suffer from ‘nerves’	3.2	5.0	6.0	-2.1	-2.2	2.2	2.5
Overall health rating	0.1	0.3	0.5	0.6	0.4	-0.7	-0.3
Chest pain or discomfort	0.0	0.0	0.1	0.3	0.0	-0.0	0.1
Had major operations	0.2	0.2	0.3	-0.6	-0.4	0.2	0.5
Age at last live birth	1.4	2.0	2.9	1.7	1.3	-1.4	-1.3
Family relationship satisfaction	0.9	1.1	1.2	-1.1	-1.0	0.9	1.1
Leg pain on walking	0.1	0.1	0.2	-0.2	-0.3	0.2	0.5
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.1	-0.4	-0.3	-0.2	0.2
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.5	0.3	0.6	-0.6	-0.7
Illness, injury, bereavement, stress in last 2 years	8.1	9.9	11.2	-2.8	-3.1	3.3	3.3
Medication: Aspirin	3.2	4.2	4.5	-2.0	-2.1	1.9	2.1
Supplements: Vitamin C	2.2	2.6	3.8	1.2	1.5	-1.9	-1.7
Knee pain experienced in last month	0.9	1.3	1.8	1.3	1.2	-0.9	-1.2
Hypertension (Self-reported)	0.3	0.8	1.1	-0.7	-1.0	0.8	1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	4.1	4.8	6.6	-1.5	-2.1	2.6	2.4
Illnesses of father: Heart disease	1.4	2.0	2.2	-1.3	-1.4	1.4	1.5
Illnesses of siblings: Diabetes	0.1	0.1	0.1	-0.2	-0.3	0.4	0.2
Smoking status: Previous	0.6	0.8	1.4	-1.2	-0.6	1.0	0.8
Forced expiratory volume in 1-second (FEV1), predicted	1.4	2.9	4.4	1.3	1.6	-2.1	-1.7
Whole body fat-free mass	2.1	12.1	15.1	3.1	3.2	-3.9	-3.6
Leg fat-free mass (right)	2.9	15.3	18.7	3.7	3.6	-4.3	-4.0
Arm fat percentage (left)	0.5	1.8	1.9	1.3	1.4	-1.3	-1.4
Average weekly red wine intake	0.5	0.8	1.2	0.6	0.9	-0.9	-1.1
Handedness (chirality/laterality): Left-handed	3.1	3.8	3.9	1.9	2.0	-1.9	-1.9
Mood swings	1.9	3.5	4.5	-1.6	-2.0	1.7	2.1
Loneliness, isolation	0.4	0.6	0.8	-0.7	-0.8	0.4	0.9
Long-standing illness, disability or infirmity	0.0	0.0	0.1	-0.0	-0.1	-0.3	0.2
Ever had bowel cancer screening	0.1	0.1	0.2	0.4	0.4	-0.2	-0.3
Diabetes diagnosed by doctor	0.1	0.1	0.1	-0.4	-0.2	0.2	0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.4	-0.7	-0.6	0.2	0.6
Friendships satisfaction	0.7	0.8	2.5	0.4	0.5	-1.6	-0.6
Qualifications: nursing, teaching	1.0	1.6	1.8	1.3	1.2	-1.2	-1.3
Commuting to job workplace: Walk	0.7	0.8	0.9	-0.9	-0.9	0.8	0.9
Eye problems/disorders: Cataract	2.8	3.3	3.6	1.8	1.9	-1.7	-1.8
Mouth/teeth dental problems: Mouth ulcers	5.6	9.0	10.1	3.1	2.8	-3.2	-2.8
Medication for cholesterol	2.5	3.8	4.7	2.1	1.7	-2.2	-1.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.4	0.6	0.5	-0.5	-0.6
Back pain experienced in last month	2.0	3.0	3.5	-1.4	-1.7	1.9	1.9
Mineral and other dietary supplements	0.9	1.3	1.4	-1.1	-1.2	1.2	1.1
Breast cancer (self-reported)	0.4	0.4	0.7	0.8	0.8	-0.2	-0.7
Asthma (self-reported)	0.1	0.2	0.5	0.7	0.4	-0.1	-0.2
Osteoporosis (self-reported)	2.0	2.4	3.5	1.9	1.5	-1.5	-1.4
Osteoarthritis (self-reported)	0.3	0.4	1.1	1.0	0.5	0.1	-0.4
Medication: Aspirin	2.0	2.6	2.8	-1.7	-1.6	1.5	1.6
Medication: Gliclazide	0.0	0.0	0.1	-0.2	0.1	-0.2	-0.1
Illnesses of father: None of the above (group 1)	3.2	3.9	4.8	2.2	2.1	-1.6	-2.0
Smoking status: Current	0.3	0.4	0.7	0.6	0.7	-0.8	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.0	0.1	0.1	0.3	0.1	0.3	-0.1
Whole body water mass	2.0	11.4	14.5	3.1	3.1	-3.8	-3.5
Leg predicted mass (right)	2.9	15.7	19.2	3.7	3.7	-4.4	-4.0
Arm fat mass (left)	0.8	3.2	3.5	1.7	1.7	-1.8	-1.9
Number of self-reported non-cancer illnesses	0.0	0.0	0.1	-0.0	0.1	-0.3	0.1
Average weekly champagne plus white wine intake	1.7	2.3	2.7	-1.6	-1.5	1.4	1.6
Miserableness	1.0	1.8	2.0	-1.4	-1.4	1.2	1.3
Guilty feelings	2.5	3.8	4.9	-1.9	-1.9	1.8	2.2
Wears glasses or contact lenses	0.0	0.0	0.0	-0.1	0.1	0.1	0.0
Ever taken oral contraceptive pill	1.6	1.8	2.5	-1.2	-1.3	1.6	1.3
Hearing aid user	8.9	10.0	10.4	3.2	3.2	-3.0	-3.2
Mother’s age at death	1.1	1.3	1.7	1.2	1.3	-0.9	-1.2
Financial situation satisfaction	0.1	0.1	0.1	-0.3	-0.1	-0.4	0.1
Tinnitus: Yes, now most or all of the time	0.8	1.0	1.9	1.4	1.0	-0.6	-0.9
Commuting to job workplace: Public transport	1.5	1.8	1.9	1.4	1.2	-1.4	-1.4
Eye problems/disorders: Glaucoma	0.0	0.0	0.1	-0.3	0.2	-0.1	-0.1
Medication: Blood pressure	1.9	3.5	4.8	-1.8	-1.7	2.2	1.8
Pain type(s) experienced in last month: Hip pain	1.3	1.7	2.1	-1.3	-1.2	1.5	1.2
Supplements: Fish oil (including cod liver oil)	0.4	0.6	0.7	0.8	0.8	-0.5	-0.8
High cholesterol (Self-reported)	0.0	0.1	0.2	-0.4	-0.2	0.0	0.3
Medication: Bendroflumethiazide	0.7	1.1	2.2	-0.5	-0.9	1.5	1.0
Medication: Paracetamol	1.3	2.0	2.7	-1.1	-1.5	1.3	1.6
Medication: Lisinopril	0.7	0.9	1.2	-1.1	-0.9	0.9	0.9
Medication: Atorvastatin	0.8	0.9	1.1	-0.9	-1.0	0.9	1.0
Illnesses of father: High blood pressure	3.1	3.8	4.0	-1.9	-1.9	2.0	2.0
Alcohol drinker status: Never	0.2	0.2	0.6	0.2	0.3	-0.8	-0.4
Ever smoked	0.4	0.6	0.8	-0.9	-0.7	0.7	0.8
Basal metabolic rate	2.0	10.9	13.7	3.0	3.1	-3.7	-3.4
Leg fat percentage (left)	0.3	1.2	1.4	-1.2	-0.9	1.2	1.0
Arm fat-free mass (left)	1.1	5.4	6.9	2.0	2.1	-2.6	-2.5
Number of operations (self-reported)	0.8	1.2	1.6	1.1	1.2	-1.0	-1.0
Average weekly beer plus cider intake	1.4	2.1	2.8	-1.2	-1.7	1.2	1.6
Irritability	0.0	0.0	0.0	-0.2	-0.1	0.2	0.2
Risk taking	0.3	0.5	0.9	-0.6	-0.6	0.9	0.6
Ever had prostate specific antigen (PSA) test	2.5	2.9	3.1	1.6	1.7	-1.8	-1.7
Fractured/broken bones in last 5 years	4.1	5.3	7.3	2.3	2.1	-2.7	-2.1
Age started oral contraceptive pill	3.0	3.7	4.7	2.0	2.2	-1.5	-2.0
Diastolic blood pressure, automated reading	0.6	1.8	2.2	-1.2	-1.4	1.3	1.5
Ever depressed for a whole week	1.9	2.3	3.1	-1.8	-1.5	1.2	1.5
Unable to work because of sickness or disability	1.8	2.4	2.7	1.6	1.5	-1.5	-1.4
Commuting to job workplace: Cycle	2.9	3.5	4.5	-1.7	-1.8	2.1	1.8
Myopia	0.9	1.3	1.7	-0.9	-1.1	1.3	1.3
Vascular/heart problems diagnosed by doctor	0.2	0.4	0.7	0.6	0.8	-0.5	-0.8
Cholesterol lowering medication	0.1	0.1	0.1	0.1	0.4	-0.3	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.5	0.7	0.0	0.0	0.2
Pain experienced in last month	0.0	0.1	0.1	-0.3	-0.3	0.2	0.2
Supplements: Calcium	0.0	0.0	0.0	0.2	0.2	0.0	0.0
Basal cell carcinoma (self-reported)	0.6	0.7	1.3	0.5	0.8	-1.1	-0.9
Heart attack/myocardial infarction (self-reported)	1.7	2.2	2.7	-1.5	-1.5	1.2	1.6
Deep venous thrombosis (DVT) (self-reported)	1.2	1.6	3.0	0.9	1.1	-1.7	-1.2
Heart disease (siblings)	2.2	2.7	3.1	-1.7	-1.8	1.5	1.6
Alcohol drinker status: Previous	0.2	0.2	0.5	-0.7	-0.5	0.2	0.4
Pack years of smoking	0.6	0.8	1.3	1.1	1.0	-0.7	-0.8
Impedance of whole body	0.9	4.5	4.9	-2.2	-1.9	2.2	2.2
Leg fat mass (left)	0.2	0.9	1.1	0.8	1.0	-1.0	-1.0
Arm predicted mass (left)	0.9	4.7	6.1	1.8	2.0	-2.5	-2.3